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Central nervous system disorder causing precocious puberty

Endpoint Browser PheWeb

E4_CENTRAL_NERVOUS_SYSTEM_DISORDER_CAUSING_PRECOCIOUS_PUBERTY

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E22.80
  • Cause of death: ICD-10 — E22.80

2 out of 7 registries used, show all original rules.

106

4. Check minimum number of events

None

106

5. Include endpoints

None

106

6. Filter based on genotype QC (FinnGen only)

82

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 82 72 10
Unadjusted period prevalence (%) 0.02 0.03 0.00
Median age at first event (years) 9.08 8.79 11.15

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
101
Matched controls
1010
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E22.80
ICD-10 Finland
Central precocious puberty
+∞
139.9
99
*
L02AE02
ATC
leuprorelin; implant, parenteral
214.7
64.1
61
7
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
11.6
31.0
41
56
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
210.4
30.5
30
*
E30.1
ICD-10 Finland
Precocious puberty
48.8
26.2
31
9
101
Kela drug reimbursment
Anterior pituitary hypofunction
19.6
12.2
18
11
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.8
11.7
25
54
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
5.3
11.5
28
68
ZXE10
NOMESCO Finland
More than one and less than three hours
4.2
11.4
47
173
H47.2
ICD-10 Finland
Optic atrophy
122.2
10.6
11
*
H01AC01
ATC
somatropin; parenteral
10.9
10.1
19
21
E23.00
ICD-10 Finland
Panhypopituitarism
109.9
9.6
10
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.8
9.2
38
137
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.3
8.8
20
45
L02AE04
ATC
triptorelin; parenteral
+∞
8.4
8
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
14.7
8.1
13
10
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
4.6
8.0
22
58
H03AA01
ATC
levothyroxine sodium; systemic
4.1
7.7
25
75
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
4.6
7.6
20
51
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
17.4
7.4
11
7
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
+∞
7.4
7
*
ZXA00
NOMESCO Finland
Right side
4.2
7.4
23
67
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
9.4
7.1
14
17
WX408
NOMESCO Finland
General anesthesy, balanced
3.2
6.9
36
148
F82
ICD-10 Finland
Specific developmental disorder of motor function
8.4
6.7
14
19
E30.9
ICD-10 Finland
Disorder of puberty, unspecified
74.3
6.5
7
*
H02AB09
ATC
hydrocortisone; systemic
6.3
6.3
16
29
102
Kela drug reimbursment
Diabetes insipidus
+∞
6.3
6
*
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
11.0
6.2
11
11

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
41
85
7.44
20.93
4.3
2.1
5.22
7.13
u/l
0.70
35
59
37
78
6.91
18.34
4.2
2.2
6.31
6.73
iu/l
0.14
30
55
13
11
13.35
7.83
2.0
1.5
4.50
5.36
nmol/l
0.13
13
11
10
11
9.94
5.42
2.9
2.5
118.20
137.82
ng/l
—
10
11
29
133
2.66
4.33
4.4
4.2
—
—
—
0
0
27
120
2.71
4.28
11.3
12.6
—
—
—
0
0
13
32
4.50
4.08
2.8
1.3
26.76
20.60
ng/l
0.73
13
32
27
126
2.56
3.86
11.5
12.9
25.37
24.90
mmol/l
0.32
27
126
22
94
2.71
3.73
1.7
1.5
527.36
306.16
mu/l
0.75
22
86
40
244
2.06
2.97
5.8
3.5
0.43
0.17
e6/l
0.46
30
176
12
39
3.35
2.89
12.9
12.1
7.43
7.43
ph
—
6
17
24
123
2.25
2.75
9.5
9.8
24.17
23.57
mmol/l
0.92
24
123
28
158
2.07
2.51
7.3
3.7
7.39
7.39
ph
0.15
19
104
9
27
3.56
2.46
15.8
16.3
23.89
23.89
mmol/l
—
9
27
6
13
4.83
2.30
3.3
2.5
—
—
—
0
0
5
9
5.77
2.24
11.2
1.9
7.40
7.39
ph
—
5
9
6
14
4.48
2.18
1.3
1.1
—
—
—
0
0
39
258
1.83
2.17
6.7
2.7
—
—
—
0
0
8
25
3.38
2.14
3.9
3.0
46.66
48.55
%
—
8
25
16
77
2.28
2.10
1.6
2.0
—
—
—
0
0
68
536
1.82
2.08
18.8
9.4
4.30
3.81
e9/l
0.86
60
462
13
57
2.47
2.08
1.3
1.6
—
—
—
0
0
6
15
4.18
2.07
4.7
4.3
2.50
2.85
e9/l
—
6
15
37
244
1.81
2.07
5.9
3.5
—
—
estimate
—
0
0
63
486
1.79
2.07
18.3
10.4
0.09
0.00
e9/l
0.49
48
384
8
26
3.25
2.06
18.3
16.6
0.48
0.57
%
—
8
26
6
16
3.92
1.96
4.7
3.4
74.50
67.44
%
—
6
16
6
16
3.92
1.96
4.7
3.4
6.17
8.06
%
—
6
16
6
16
3.92
1.96
3.2
1.1
93.00
191.19
pmol/l
—
6
16
43
301
1.75
1.95
11.8
7.6
—
—
—
0
0
8
28
3.01
1.91
18.3
15.6
96.22
95.51
%
—
8
28
8
28
3.01
1.91
18.3
15.6
0.81
0.91
%
—
8
28
52
386
1.72
1.90
6.0
3.0
—
—
estimate
—
0
0
27
166
1.86
1.87
2.1
3.5
6.91
1.37
mg/l
0.51
18
111
6
17
3.68
1.86
2.0
3.6
13.83
16.29
%
—
6
17
5
12
4.32
1.84
3.6
5.8
0.84
1.59
ug/l
—
5
12
18
97
2.04
1.80
1.6
1.7
—
—
—
0
0
5
13
3.99
1.73
1.0
2.0
—
—
—
0
0
35
240
1.70
1.67
3.8
3.5
—
—
—
0
0
52
397
1.64
1.64
2.3
2.4
—
—
—
0
0
14
72
2.10
1.58
1.3
1.3
—
—
—
0
0
39
279
1.65
1.57
5.9
3.5
66.99
47.06
e6/l
0.20
29
207
21
126
1.84
1.55
1.7
2.4
7.12
14.61
ng/l
—
10
37
5
15
3.45
1.54
2.0
6.1
29.20
34.80
umol/l
—
5
15
6
21
2.97
1.53
4.2
5.1
68.48
59.71
g/l
—
6
21
13
66
2.11
1.51
16.7
12.2
105.23
105.71
mmol/l
0.09
13
66
5
16
3.23
1.45
2.0
3.4
34.20
26.38
%
—
5
16
15
82
1.97
1.45
2.1
1.3
326.95
501.06
u/ml
0.20
15
77
61
495
1.59
1.42
15.2
8.2
33.73
33.33
%
0.12
61
485
17
98
1.88
1.42
8.6
7.2
—
—
—
0
0
58
467
1.57
1.39
15.7
8.5
8.52
8.35
%
0.21
58
453
6
23
2.71
1.39
10.2
11.6
65.40
70.74
%
—
6
23
92
843
2.02
1.34
25.1
14.0
332.78
334.38
g/l
0.84
92
836
60
490
1.55
1.32
14.5
8.1
51.99
52.97
%
0.28
60
480
57
461
1.54
1.31
16.0
8.6
0.52
0.63
%
0.86
57
446
49
386
1.52
1.26
3.6
3.2
6.17
6.37
ph
0.44
23
182
43
331
1.52
1.22
16.3
9.2
—
—
—
0
0
93
863
1.98
1.15
17.0
10.7
23.23
21.29
mg/l
0.20
86
643
17
106
1.73
1.11
1.6
2.5
—
—
—
0
0
91
838
1.87
1.05
19.0
9.7
61.35
60.99
umol/l
0.09
91
824
61
517
1.45
1.02
14.8
8.2
2.31
2.12
e9/l
1.08
54
460
44
351
1.45
1.01
7.3
4.3
60.69
71.26
e6/l
0.10
31
221
65
559
1.46
0.99
4.1
2.7
1.35
1.09
mmol/l
2.15
65
534
58
489
1.44
0.98
15.4
8.6
0.04
0.04
e9/l
0.01
50
422
58
490
1.43
0.96
15.3
8.5
0.60
0.53
e9/l
0.98
50
423
55
461
1.42
0.95
4.7
3.5
0.00
0.00
estimate
-0.00
12
94
16
103
1.66
0.94
1.6
1.4
—
—
—
0
0
55
464
1.41
0.90
4.6
3.5
0.00
0.00
estimate
-0.00
12
91
55
468
1.38
0.84
4.6
3.6
0.00
0.00
estimate
-0.00
13
92
6
33
1.87
0.80
1.2
1.2
—
—
—
0
0
5
23
2.23
0.77
13.0
10.8
73.74
70.27
%
—
5
23
5
25
2.05
0.74
1.8
4.6
—
—
—
0
0
94
893
1.76
0.73
11.5
8.2
—
—
—
0
0
11
69
1.67
0.72
6.5
3.3
—
—
—
0
0
16
111
1.52
0.71
11.4
7.8
7.41
7.41
ph
0.24
16
88
13
86
1.59
0.70
1.4
1.4
—
—
—
0
0
58
507
1.34
0.70
17.7
8.9
0.18
0.19
e9/l
0.21
50
442
5
27
1.89
0.69
2.0
4.4
961.40
266.93
mg/l
—
5
27
11
70
1.64
0.68
1.5
1.1
—
—
—
0
0
14
96
1.53
0.65
12.7
6.9
10.42
10.01
kpa
0.49
14
91
5
29
1.76
0.64
1.8
1.9
—
—
—
0
0
16
114
1.48
0.63
3.3
2.9
15.59
14.86
umol/l
0.09
16
105
8
51
1.62
0.62
1.0
1.1
—
—
—
0
0
19
141
1.43
0.62
2.1
1.9
—
—
—
0
0
5
30
1.70
0.62
1.2
2.0
—
—
—
0
0
0
21
0.00
0.61
0.0
2.8
—
1.62
—
0
12
0
21
0.00
0.61
0.0
1.2
—
1.53
—
0
11
12
81
1.55
0.60
1.5
1.5
—
—
—
0
0
24
188
1.36
0.58
1.7
1.7
—
—
—
0
0
20
152
1.39
0.58
3.5
3.5
11.50
3.21
e6/l
—
10
70
6
37
1.66
0.56
3.8
1.2
425.00
335.03
mu/l
—
6
29
6
38
1.61
0.55
1.5
1.3
—
—
—
0
0
42
360
1.29
0.55
2.0
1.7
1.68
1.74
g/l
0.13
20
199
29
238
1.31
0.52
5.2
3.4
0.00
0.00
estimate
-0.00
11
91
14
103
1.42
0.48
1.6
2.2
514.17
748.94
ng/l
—
6
34
13
95
1.42
0.46
5.1
2.0
4.19
4.17
e9/l
0.01
13
89
5
32
1.59
0.43
1.2
1.3
25.00
20.58
u/ml
—
5
32
33
380
0.80
0.42
2.5
2.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
5.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
2.88
—
0
17
11
80
1.42
0.40
1.5
1.6
—
—
—
0
0
14
107
1.36
0.40
3.9
2.9
2.68
2.57
g/l
0.21
14
97
18
219
0.78
0.36
11.4
4.4
—
—
—
0
0
20
165
1.26
0.34
1.4
1.3
—
—
—
0
0
10
74
1.39
0.34
2.9
2.1
—
—
—
0
0
29
251
1.22
0.33
4.0
2.7
0.00
0.00
estimate
-0.00
11
81
64
597
1.20
0.33
6.3
4.3
—
—
—
0
0
26
298
0.83
0.30
2.1
1.8
—
—
—
0
0
10
76
1.35
0.29
1.1
1.2
1.10
0.61
u/ml
—
5
53
36
325
1.17
0.26
4.6
3.2
0.00
0.01
estimate
—
10
81
13
106
1.26
0.24
1.0
1.2
—
—
—
0
0
44
406
1.15
0.24
1.7
1.9
0.51
2.37
u/ml
—
8
85
5
39
1.30
0.23
2.8
3.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
0.42
—
0
10
0
10
0.00
0.21
0.0
1.0
—
25.38
—
0
10
0
12
0.00
0.21
0.0
1.6
—
288.58
—
0
12
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
4.30
—
0
12
0
13
0.00
0.21
0.0
10.4
—
10.33
—
0
13
0
14
0.00
0.20
0.0
1.1
—
8.44
—
0
14
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
41
384
1.11
0.16
1.8
1.8
—
—
—
0
0
13
150
0.85
0.16
2.5
1.7
—
—
—
0
0
13
114
1.16
0.12
1.8
1.5
—
—
—
0
0
29
271
1.10
0.11
3.2
2.3
—
—
—
0
0
5
43
1.17
0.10
1.8
1.6
—
—
—
0
0
5
44
1.14
0.10
1.2
1.1
—
15.51
—
0
8
33
346
0.93
0.08
2.1
1.9
—
—
—
0
0
26
245
1.08
0.08
1.5
1.5
104.01
93.11
pmol/l
0.67
13
119
15
163
0.91
0.07
2.5
1.7
—
—
—
0
0
22
234
0.92
0.07
1.9
1.7
—
—
—
0
0
19
177
1.09
0.07
2.4
2.5
10336.14
5855.92
u/l
—
5
70
15
162
0.91
0.06
2.5
1.7
—
—
—
0
0
15
162
0.91
0.06
2.5
1.7
—
—
—
0
0
15
162
0.91
0.06
2.5
1.7
—
—
—
0
0
10
90
1.12
0.05
2.0
2.2
—
—
—
0
0
24
252
0.94
0.05
2.7
1.7
—
—
—
0
0
44
451
0.96
0.04
3.2
2.6
—
—
—
0
0
14
134
1.05
0.00
2.2
1.8
—
—
—
0
0
14
137
1.03
0.00
1.4
1.7
—
—
—
0
0
25
246
1.02
0.00
3.0
3.1
1.02
1.02
kg/l
0.99
14
148
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
3.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
5.39
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
8.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1336.50
—
0
6
0
6
0.00
-0.00
0.0
2.5
—
3.22
—
0
6
12
120
1.00
-0.00
2.2
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
-0.00
2.0
2.2
—
19.68
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.2
—
1.38
—
0
5
0
6
0.00
-0.00
0.0
11.2
—
1.23
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
1773.57
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
125.57
—
0
7
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
8.40
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
177.40
—
0
5
0
5
0.00
-0.00
0.0
4.0
—
241.60
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
0.55
—
0
5

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: E4_CENTRAL_NERVOUS_SYSTEM_DISORDER_CAUSING_PRECOCIOUS_PUBERTY – Central nervous system disorder causing precocious puberty

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).