Precocious central puberty

E4_PRECOXCENTPUB

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E22.80, E22.88
  • Hospital discharge: ICD-9 259
  • Cause of death: ICD-10 E22.80, E22.88
  • Cause of death: ICD-9 259

2 out of 7 registries used, show all original rules.

261

4. Check minimum number of events

None

261

5. Include endpoints

None

261

6. Filter based on genotype QC (FinnGen only)

219

Control definitions (FinnGen only)

Control exclude
E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF6

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2852 1930 912
Only index persons 2430 1642 788
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.03
Only index persons 0.05 0.06 0.03
Median age at first event (years)
Whole population 9.59 8.54 11.31
Only index persons 9.31 8.52 10.97

-FinnGen-

Key figures

All Female Male
Number of individuals 219 151 68
Unadjusted period prevalence (%) 0.05 0.05 0.03
Median age at first event (years) 10.41 8.94 13.69

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
241
Matched controls
2410
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L02AE02
ATC
leuprorelin; implant, parenteral
68.1
115.8
65
13
E22.80
ICD-10 Finland
Central precocious puberty
+∞
112.6
99
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
18.5
50.7
43
28
2594A
ICD-9 Finland
Other endocrine disorders, Dwarfism, not elsewhere classified
+∞
49.7
46
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
37.5
35
*
E30.1
ICD-10 Finland
Precocious puberty
+∞
36.4
34
*
H01AC01
ATC
somatropin; parenteral
+∞
35.3
33
*
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
+∞
32.0
30
*
H02AB09
ATC
hydrocortisone; systemic
11.2
26.1
29
29
E22.88
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
22.2
21
*
2591A
ICD-9 Finland
Other endocrine disorders, Precocious sexual development and puberty, not elsewhere classified
+∞
22.2
21
*
2590A
ICD-9 Finland
Other endocrine disorders, Delay in sexual development and puberty, not elsewhere classified
+∞
20.1
19
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
17.9
17
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
16.9
16
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
91.1
15.8
17
*
L02AE04
ATC
triptorelin; parenteral
+∞
14.7
14
*
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
159.3
14.6
15
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.6
14.1
37
92
2599X
ICD-9 Finland
Other endocrine disorders, Unspecified endocrine disorder
+∞
13.7
13
*
2592A
ICD-9 Finland
Other endocrine disorders, Carcinoid syndrome
+∞
12.6
12
*
7834C
ICD-9 Finland
Symptoms concerning nutrition, metabolism and development, Lack of expected normal physiological development[HÄIRIINTYNYT PITUUSKASVU]
+∞
12.6
12
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
136.8
12.6
13
*
H47.2
ICD-10 Finland
Optic atrophy
45.5
11.0
13
*
E22.1
ICD-10 Finland
Hyperprolactinaemia
62.9
10.7
12
*
102
Kela drug reimbursment
Diabetes insipidus
+∞
10.5
10
*
E34.35
ICD-10 Finland
Abnormal growth retardation
57.4
9.7
11
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
9.6
71
334
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
5.5
9.5
19
37
2598X
ICD-9 Finland
Other endocrine disorders, Other specified endocrine disorders
+∞
9.4
9
*
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
+∞
9.4
9
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.4
9.2
83
428
301
Kela drug reimbursment
Growth hormone
+∞
8.4
8
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.2
8.2
34
116
F82
ICD-10 Finland
Specific developmental disorder of motor function
9.3
7.7
15
17
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
13.9
7.5
12
9
E34.31
ICD-10 Finland
Short stature, prenatal disorder
82.5
7.5
8
*
F83
ICD-10 Finland
Mixed specific developmental disorders
8.8
7.4
15
18
E30.9
ICD-10 Finland
Disorder of puberty, unspecified
+∞
7.3
7
*
E22.8
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
7.3
7
*
E30.8
ICD-10 Finland
Other disorders of puberty
+∞
7.3
7
*
L04AA01
ATC
[U] ciclosporin
20.8
7.2
10
5
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
4.4
7.1
18
43
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
4.3
6.9
18
44
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
6.4
6.9
17
28
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
6.9
50
230
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.3
6.9
27
89
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
41.2
6.8
8
*
G03DB01
ATC
dydrogesterone; oral
3.1
6.7
29
101
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.4
6.7
25
80
G81.1
ICD-10 Finland
Spastic hemiplegia
71.7
6.5
7
*
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
14.8
6.5
10
7
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.3
6.3
54
267
E34.45
ICD-10 Finland
Abnormal growth increase
+∞
6.3
6
*
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
+∞
6.3
6
*
E34.30
ICD-10 Finland
Short stature NOS
+∞
6.3
6
*
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
6.3
6
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
6.3
44
199
G91.1
ICD-10 Finland
Obstructive hydrocephalus
27.5
6.3
8
*
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.7
6.2
36
148
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.7
6.0
19
54

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
56
112
6.21
28.17
3.7
1.5
6.33
7.88
u/l
0.63
49
87
57
143
4.91
21.96
3.5
1.5
11.15
13.56
iu/l
0.36
47
113
72
340
2.59
9.66
5.5
3.8
—
—
—
0
0
100
559
2.35
9.22
5.8
7.4
1.07
1.12
inr
0.87
83
466
113
689
2.21
8.24
11.9
7.1
1.22
1.21
mmol/l
0.07
102
650
19
30
6.78
7.89
2.8
1.5
26.58
20.65
ng/l
0.83
19
30
120
786
2.05
6.91
13.3
7.0
1.21
1.22
mmol/l
0.05
104
700
41
184
2.48
5.93
9.4
9.8
25.20
24.85
mmol/l
0.30
41
184
144
1047
1.93
5.77
7.8
4.7
6.09
6.22
mmol/l
0.37
137
940
30
120
2.71
5.46
15.0
9.9
7.43
7.42
ph
0.29
16
62
72
421
2.01
5.44
5.7
3.3
7.40
7.39
ph
0.17
54
285
119
826
1.87
5.37
7.3
5.1
9.82
11.67
umol/l
1.54
112
774
219
1897
2.69
4.96
21.5
10.1
3.91
3.90
mmol/l
0.15
212
1839
219
1900
2.67
4.89
21.7
10.1
139.52
139.49
mmol/l
0.06
212
1852
40
196
2.25
4.73
9.5
9.4
—
—
—
0
0
101
690
1.80
4.62
12.2
6.7
—
—
—
0
0
8
8
10.29
4.55
5.8
1.0
3.15
1.88
nmol/l
—
8
8
7
6
11.96
4.30
4.0
1.0
536.29
53.83
nmol/l
—
7
6
151
1181
1.75
4.15
14.3
8.6
4.51
3.85
e9/l
2.59
138
1028
7
7
10.25
4.03
2.0
1.0
—
—
—
0
0
19
70
2.86
4.02
11.2
12.6
23.84
24.01
mmol/l
0.09
19
70
93
648
1.71
3.81
7.5
4.8
36.58
38.02
g/l
1.82
83
617
60
370
1.83
3.74
4.6
2.4
9.99
8.74
e6/l
0.23
55
335
76
503
1.75
3.73
2.9
2.4
47.96
57.84
u/l
2.36
69
469
41
223
2.01
3.71
7.1
6.2
7.37
7.37
ph
0.19
33
137
40
217
2.01
3.64
7.1
6.3
5.89
5.68
kpa
1.00
40
210
39
211
2.01
3.57
2.7
2.0
—
—
—
0
0
31
154
2.16
3.54
17.3
7.6
8.06
6.30
mmol/l
0.96
31
149
77
520
1.71
3.49
3.1
2.4
2.37
2.35
mmol/l
0.47
72
489
34
177
2.07
3.45
13.3
8.7
104.97
105.46
mmol/l
0.16
34
177
72
481
1.71
3.38
3.9
2.6
12.86
29.64
ng/l
1.38
44
217
159
1300
1.66
3.35
9.5
6.0
83.57
78.58
u/l
0.53
152
1237
12
33
3.77
3.34
9.7
2.0
—
—
—
0
0
13
39
3.46
3.28
6.2
2.4
7.41
7.41
ph
0.13
13
39
28
138
2.16
3.27
4.2
5.4
1.60
1.18
%
—
10
34
9
21
4.41
3.02
5.9
2.0
17.09
16.97
%
—
9
21
73
505
1.64
2.96
4.9
2.9
0.44
0.26
e6/l
0.35
57
351
35
196
1.92
2.91
7.5
6.4
5.15
4.84
kpa
0.23
35
191
14
53
2.74
2.85
5.9
2.1
24.39
23.79
mmol/l
0.25
14
53
9
23
4.02
2.80
2.2
1.7
—
—
—
0
0
9
23
4.02
2.80
2.2
1.7
—
—
—
0
0
9
23
4.02
2.80
2.2
1.7
—
—
—
0
0
9
23
4.02
2.80
2.2
1.7
—
—
—
0
0
187
1634
1.64
2.64
6.2
4.3
14.43
14.40
pmol/l
0.06
177
1508
132
1072
1.51
2.56
12.4
6.6
0.60
0.54
e9/l
1.85
116
938
132
1073
1.51
2.54
12.4
6.6
0.04
0.04
e9/l
0.35
116
938
25
131
2.01
2.51
4.6
5.5
0.25
0.20
%
—
8
25
9
26
3.55
2.51
7.8
2.3
5.11
5.10
kpa
—
9
26
9
26
3.55
2.51
7.8
2.3
10.23
9.37
kpa
—
9
26
75
543
1.55
2.47
3.6
2.3
—
—
—
0
0
17
77
2.30
2.44
12.5
12.7
0.63
0.65
%
0.09
17
77
37
224
1.77
2.42
4.3
3.7
13.95
5.30
umol/l
0.59
31
181
30
170
1.87
2.42
8.0
6.3
23.91
23.53
mmol/l
0.40
30
170
37
226
1.75
2.35
2.2
1.5
—
—
—
0
0
78
577
1.52
2.31
5.1
2.9
37.34
52.00
e6/l
0.29
62
416
10
34
3.02
2.31
1.2
1.2
—
—
—
0
0
18
86
2.18
2.29
1.7
1.5
—
—
—
0
0
135
1118
1.47
2.27
12.5
6.5
2.06
2.03
e9/l
0.22
121
1008
10
35
2.94
2.23
1.4
1.3
248.20
315.77
ug/g
—
5
16
11
42
2.69
2.17
20.6
4.4
0.91
0.73
%
1.17
11
36
9
31
2.98
2.09
2.0
2.4
—
—
—
0
0
6
15
4.07
2.05
2.2
1.2
1.89
1.75
mmol/l
—
6
15
80
608
1.47
2.05
9.7
6.3
—
—
—
0
0
28
165
1.79
2.02
1.4
1.5
—
—
—
0
0
5
11
4.62
1.95
1.0
1.3
—
—
—
0
0
11
46
2.46
1.88
21.3
4.3
1.89
1.57
%
0.49
11
39
16
80
2.07
1.84
13.1
12.3
0.94
1.24
%
1.17
16
80
5
12
4.23
1.83
1.0
1.3
—
—
—
0
0
9
35
2.63
1.82
4.8
2.7
—
—
—
0
0
186
1675
1.48
1.80
4.1
3.3
5.67
5.56
mmol/l
0.49
175
1546
24
140
1.79
1.80
4.7
5.5
0.20
0.11
%
—
5
27
132
1123
1.39
1.73
13.8
6.8
0.16
0.19
e9/l
1.32
118
991
7
24
2.97
1.73
3.0
2.0
—
—
—
0
0
23
134
1.79
1.73
10.3
5.5
—
—
—
0
0
204
1877
1.57
1.73
6.6
5.0
1.68
1.74
mu/l
0.49
196
1779
87
692
1.40
1.70
2.2
1.8
1.48
1.32
mmol/l
1.01
79
623
30
191
1.65
1.67
3.2
2.5
10.45
10.30
g/l
0.08
25
178
118
992
1.37
1.64
17.6
9.4
0.05
0.00
e9/l
0.50
95
805
18
99
1.88
1.62
3.0
2.2
0.31
0.13
e6/l
0.60
18
90
6
20
3.05
1.59
2.0
3.5
13.83
15.60
%
—
6
20
10
44
2.33
1.57
1.3
1.3
3.60
3.64
u/ml
—
5
22
27
170
1.66
1.57
11.1
5.0
7.41
7.41
ph
0.19
27
142
58
435
1.44
1.56
1.7
2.3
3.66
0.99
mg/l
0.53
38
312
22
131
1.75
1.55
3.5
5.3
0.83
1.07
%
—
6
29
8
33
2.47
1.55
3.9
3.8
3.44
4.14
e9/l
—
8
33
5
15
3.38
1.53
3.0
1.3
—
—
nmol/l
—
0
0
19
109
1.81
1.52
6.7
4.0
68.94
70.66
e9/l
0.07
13
73
27
172
1.64
1.51
11.2
5.0
5.09
4.96
kpa
0.43
27
166
109
914
1.35
1.50
4.6
2.7
—
—
estimate
—
0
0
190
1740
1.43
1.48
4.2
3.5
1.40
1.44
mmol/l
0.54
182
1657
17
95
1.85
1.47
27.8
10.9
1.29
1.05
mg/l
0.88
17
88
11
52
2.17
1.47
9.3
4.2
—
—
—
0
0
13
236
0.53
1.46
1.0
1.6
3.46
3.33
mmol/l
—
7
158
32
215
1.56
1.45
1.8
1.4
—
—
—
0
0
172
1553
1.38
1.43
5.2
4.2
37.34
36.87
mmol/mol
0.22
166
1480
191
1755
1.43
1.42
4.4
3.8
2.80
2.77
mmol/l
0.20
183
1673
6
23
2.65
1.37
4.7
3.0
6.17
10.74
%
—
6
23
6
23
2.65
1.37
4.7
3.0
74.50
69.70
%
—
6
23
5
17
2.98
1.36
8.2
3.6
—
—
—
0
0
70
555
1.37
1.36
5.4
3.3
0.00
0.01
estimate
0.80
25
208
190
1749
1.41
1.36
4.4
3.6
4.62
4.60
mmol/l
0.09
182
1675
67
528
1.37
1.35
5.0
3.9
8.46
8.60
mmol/l
0.06
56
474
75
605
1.35
1.30
5.0
2.2
—
—
—
0
0
156
1398
1.33
1.29
4.6
3.3
51.47
31.90
u/l
0.68
148
1350
11
55
2.05
1.29
1.3
1.1
—
—
—
0
0
14
77
1.87
1.28
6.4
6.1
107.89
376.12
mg/l
—
9
49
223
2124
1.67
1.28
15.8
9.1
—
—
—
0
0
87
720
1.33
1.27
6.1
3.6
77.54
54.11
e6/l
0.37
66
445
40
295
1.43
1.18
3.4
2.8
7.93
3.55
e6/l
0.97
23
127
123
1076
1.29
1.17
5.3
3.3
0.00
6.94
estimate
0.50
29
217
44
571
0.72
1.17
1.9
1.7
—
—
—
0
0
0
34
0.00
1.17
0.0
1.1
—
1.17
—
0
15
5
20
2.53
1.15
1.0
1.3
—
—
—
0
0
5
20
2.53
1.15
2.0
3.3
34.20
26.20
%
—
5
20
24
160
1.56
1.14
1.5
1.2
—
—
—
0
0
7
30
2.37
1.13
1.4
1.2
3747.29
5049.11
e6/l
—
7
19
10
51
2.00
1.13
5.7
1.3
524.10
303.95
mu/l
—
10
39
10
51
2.00
1.13
3.4
3.0
51.73
54.04
%
—
10
51
63
506
1.33
1.12
4.5
2.8
1.02
1.02
kg/l
0.02
42
299
42
316
1.40
1.12
1.4
1.5
464.00
511.72
titre
—
10
58
121
1066
1.27
1.06
5.3
3.3
0.00
0.00
estimate
-0.00
26
220
38
284
1.40
1.05
1.4
1.2
—
—
—
0
0
19
283
0.64
1.04
1.1
1.3
—
—
—
0
0
135
1207
1.27
1.04
4.7
3.2
80.94
67.22
ug/l
0.44
126
1151
5
22
2.30
1.04
10.6
16.2
1033.00
752.68
nmol/l
—
5
22
22
148
1.54
1.02
2.7
1.8
0.00
0.00
estimate
—
6
43
215
2050
1.45
1.00
19.6
10.3
24.64
20.37
mg/l
0.99
190
1581
5
23
2.20
0.98
15.6
22.3
1670.20
1368.83
nmol/l
—
5
23
30
218
1.43
0.97
1.2
1.3
—
—
—
0
0
122
1084
1.25
0.97
5.3
3.3
0.00
0.00
estimate
-0.00
30
207
50
397
1.33
0.96
2.4
2.8
84.14
78.47
ug/g
0.10
39
306
7
37
1.92
0.95
10.3
6.7
65.81
65.68
%
—
7
37
42
326
1.35
0.94
5.5
4.9
5.67
13.50
mg/mmol
1.12
29
226
36
273
1.37
0.93
2.7
2.7
756.00
493.63
ng/l
0.25
20
123
6
28
2.17
0.92
1.2
1.3
—
—
—
0
0
233
2273
1.76
0.86
28.7
16.3
4.56
4.59
e12/l
0.31
228
2228
233
2270
1.80
0.86
28.5
16.3
272.81
261.97
e9/l
1.67
228
2232
11
176
0.61
0.83
1.2
1.2
—
152.00
—
0
5
0
24
0.00
0.79
0.0
1.0
—
—
—
0
0
74
635
1.24
0.78
4.8
2.6
0.00
0.02
estimate
0.68
27
188
100
886
1.22
0.77
4.4
3.0
6.35
6.26
ph
0.34
54
472
174
1630
1.24
0.77
3.8
3.1
1.32
1.17
mmol/l
2.03
167
1547
233
2275
1.73
0.75
28.9
16.4
7.21
6.76
e9/l
2.50
228
2225
19
134
1.45
0.74
1.0
1.1
—
—
—
0
0
5
25
2.02
0.73
16.6
3.1
5.92
7.65
pmol/l
—
5
25
5
25
2.02
0.73
2.2
3.4
—
—
—
0
0
51
423
1.26
0.72
1.6
1.7
—
—
—
0
0
9
57
1.60
0.72
2.8
6.3
36.97
36.96
°c
—
9
57
36
286
1.30
0.70
2.1
2.3
6482.21
5653.76
u/l
—
8
122
29
223
1.34
0.70
1.2
1.3
147.50
166.68
u/ml
—
7
88
7
43
1.65
0.67
5.3
1.9
133.14
134.94
g/l
—
7
35
23
173
1.36
0.64
4.8
3.5
—
—
—
0
0
5
29
1.74
0.64
1.4
1.4
0.44
0.53
e9/l
—
5
29
91
813
1.19
0.63
5.2
3.0
0.08
0.02
estimate
0.33
24
189
23
174
1.36
0.63
1.3
1.2
—
—
—
0
0
8
50
1.62
0.62
1.0
2.2
—
—
—
0
0
47
394
1.24
0.61
1.5
1.4
21.37
19.97
nmol/l
0.28
39
348
33
265
1.28
0.61
1.6
1.6
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
2.50
—
0
20
44
367
1.24
0.60
1.3
1.3
56.85
19.24
iu/ml
0.44
14
89
8
54
1.50
0.58
2.3
3.0
—
—
—
0
0
23
177
1.33
0.57
1.1
1.1
—
—
—
0
0
6
36
1.68
0.57
11.0
6.5
68.63
65.14
%
—
6
36
20
260
0.75
0.56
1.8
2.0
—
—
—
0
0
39
325
1.24
0.54
5.2
4.1
27.28
98.77
mg/l
2.11
30
233
61
533
1.19
0.53
3.1
2.2
2.57
2.48
mg/l
0.12
51
467
20
153
1.33
0.52
1.1
1.4
246.80
250.26
miu/ml
—
10
82
18
233
0.75
0.50
2.2
1.3
—
—
—
0
0
7
45
1.57
0.49
2.0
1.9
—
—
—
0
0
11
76
1.47
0.49
2.4
1.5
—
—
—
0
0
23
286
0.78
0.48
3.9
1.7
—
—
—
0
0
23
285
0.79
0.47
3.9
1.7
—
—
—
0
0
23
285
0.79
0.47
3.9
1.7
—
—
—
0
0
72
647
1.16
0.45
1.9
1.6
99.30
97.27
pmol/l
0.14
34
344
23
284
0.79
0.45
3.9
1.7
—
—
—
0
0
24
194
1.26
0.44
1.3
1.4
—
—
—
0
0
21
260
0.79
0.43
4.0
1.7
—
—
—
0
0
55
487
1.17
0.42
4.2
3.3
—
0.00
—
0
5
26
214
1.24
0.41
3.2
2.0
—
—
—
0
0
5
33
1.53
0.41
2.0
4.1
—
—
—
0
0
11
79
1.41
0.41
2.0
1.5
1.21
1.21
g/l
0.00
11
74
0
15
0.00
0.41
0.0
3.2
—
—
—
0
0
0
17
0.00
0.41
0.0
2.4
—
41.33
—
0
6
74
672
1.15
0.41
1.8
1.5
1.82
2.01
g/l
0.73
41
411
81
743
1.14
0.38
1.6
1.6
0.58
2.38
u/ml
1.85
17
182
9
67
1.36
0.38
1.1
1.1
—
15.09
—
0
24
14
107
1.33
0.38
6.3
4.5
7.39
7.33
ph
—
9
82
61
670
0.88
0.34
2.2
2.0
—
—
—
0
0
15
120
1.27
0.31
1.4
1.2
—
—
—
0
0
7
56
1.26
0.29
1.1
1.1
—
—
—
0
0
5
75
0.66
0.26
1.0
1.1
—
—
—
0
0
5
75
0.66
0.26
1.0
1.1
—
—
—
0
0
195
1906
1.12
0.25
22.3
13.3
333.26
334.34
g/l
0.83
195
1892
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
73.18
—
0
11
0
10
0.00
0.21
0.0
9.4
—
9.90
—
0
10
0
10
0.00
0.21
0.0
4.7
—
46.30
—
0
10
0
10
0.00
0.21
0.0
1.6
—
20878.00
—
0
5
0
12
0.00
0.21
0.0
1.0
—
23.32
—
0
12
77
812
0.92
0.20
2.6
2.3
—
—
—
0
0
11
90
1.23
0.19
1.5
1.4
—
—
—
0
0
10
120
0.83
0.17
1.9
1.7
0.43
0.54
ug/l
—
5
42
8
72
1.11
0.16
1.4
1.5
—
—
—
0
0
38
352
1.09
0.16
1.2
1.3
3.00
6.96
u/ml
0.85
12
149
9
79
1.14
0.15
8.7
5.6
0.74
0.64
%
—
9
79
10
118
0.84
0.14
1.0
1.1
—
—
—
0
0
56
532
1.07
0.13
6.0
4.4
—
—
—
0
0
69
720
0.94
0.13
1.8
1.8
—
—
—
0
0
21
229
0.91
0.11
2.2
1.6
—
—
—
0
0
19
208
0.91
0.11
2.7
2.2
—
—
—
0
0
5
44
1.14
0.10
1.0
1.1
—
—
—
0
0
67
647
1.05
0.09
2.5
1.8
—
—
—
0
0
8
74
1.08
0.07
1.3
1.5
—
92.50
—
0
8
14
128
1.10
0.07
2.9
2.0
—
—
—
0
0
12
132
0.90
0.07
1.1
1.2
0.16
3.64
u/ml
—
7
84
9
103
0.87
0.06
1.0
1.0
1.43
1.55
g/l
—
9
103
82
803
1.03
0.06
1.6
1.8
—
—
—
0
0
15
161
0.93
0.05
1.5
1.6
—
—
—
0
0
10
91
1.10
0.04
1.2
1.5
478.00
210.33
u/ml
—
5
50
10
98
1.02
0.00
2.0
2.0
—
5.32
—
0
21
15
149
1.01
0.00
1.1
1.1
—
—
—
0
0
16
159
1.01
0.00
1.4
1.5
—
—
—
0
0
89
888
1.00
0.00
2.6
2.4
—
—
—
0
0
10
103
0.97
0.00
1.0
1.0
0.87
0.86
g/l
—
10
103
11
114
0.96
0.00
1.1
1.2
1.10
0.59
u/ml
—
5
70
11
115
0.95
0.00
1.1
1.2
2.06
6.35
u/ml
—
6
87
0
5
0.00
0.00
0.0
1.0
—
184.00
—
0
5
0
5
0.00
0.00
0.0
1.0
—
76.80
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
10.64
—
0
5
6
59
1.02
-0.00
1.5
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
89
1.01
-0.00
1.1
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
8.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
-0.00
2.1
1.6
—
—
—
0
0
5
52
0.96
-0.00
1.6
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
2120.71
—
0
7
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
77
0.91
-0.00
1.4
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
32.60
—
0
7
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
67
0.89
-0.00
1.2
1.2
—
3.67
—
0
6
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint E4_PRECOXCENTPUB and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_PRECOXCENTPUB.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: E4_PRECOXCENTPUB – Precocious central puberty

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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