No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
209 |
4. Check minimum number of eventsNone |
209 |
5. Include endpointsNone |
209 |
6. Filter based on genotype QC (FinnGen only) |
178 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E30
- Name in latin
- Pubertas praecox
Similar endpoints
↥List of similar endpoints to
Precocious puberty
based on the number of shared cases.
Similar with more cases:
- Disorders of puberty
- Disorders of puberty, all
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3614 | 2856 | 755 |
| Only index persons | 3025 | 2327 | 698 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.08 | 0.02 |
| Only index persons | 0.07 | 0.09 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 9.48 | 8.97 | 11.38 |
| Only index persons | 9.57 | 9.01 | 11.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 178 | 149 | 29 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.01 |
| Median age at first event (years) | 9.58 | 8.98 | 12.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 199
- Matched controls
- 1990
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E30.1
ICD-10 Finland
Precocious puberty
13072.1
240.3
181
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
16.8
51.2
47
36
L02AE02
ATC
leuprorelin; implant, parenteral
62.2
38.5
44
9
E22.80
ICD-10 Finland
Central precocious puberty
412.2
35.1
34
*
2591A
ICD-9 Finland
Other endocrine disorders, Precocious sexual development and puberty, not elsewhere classified
+∞
22.3
21
*
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
+∞
20.1
19
*
E27.0
ICD-10 Finland
Other adrenocortical overactivity
184.9
16.8
17
*
E34.45
ICD-10 Finland
Abnormal growth increase
93.9
8.5
9
*
L02AE04
ATC
triptorelin; parenteral
+∞
8.4
8
*
E30.8
ICD-10 Finland
Other disorders of puberty
+∞
8.4
8
*
Z3231
NOMESCO Finland
Registered nurse
2.3
7.1
73
398
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
14.9
6.5
10
7
XLA10, ,
NOMESCO Finland
72.1
6.5
7
*
E30.9
ICD-10 Finland
Disorder of puberty, unspecified
+∞
6.3
6
*
H01AC01
ATC
somatropin; parenteral
+∞
6.3
6
*
U04
ICPC
Incontinence urine
10.5
6.1
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
47
109
5.34
20.01
3.4
1.8
7.26
8.60
iu/l
0.27
36
76
47
123
4.69
17.19
3.6
1.7
4.82
6.80
u/l
1.79
34
85
22
25
9.75
11.10
1.6
2.2
4.12
6.16
umol/l
1.14
22
20
14
11
13.58
8.51
2.2
3.5
5.24
2.95
nmol/l
0.70
14
11
89
613
1.82
4.07
17.4
8.3
1.21
1.22
mmol/l
0.49
81
557
83
579
1.74
3.52
6.5
4.6
8.39
11.77
umol/l
2.72
76
529
24
108
2.39
3.48
21.3
13.4
105.63
106.55
mmol/l
0.33
24
108
40
225
1.97
3.35
22.8
9.8
24.87
24.86
mmol/l
0.01
40
225
15
55
2.87
3.23
27.9
8.6
0.61
0.59
%
0.13
15
55
171
1488
2.06
3.20
16.2
9.0
3.86
3.87
mmol/l
0.09
165
1433
171
1494
2.03
3.07
16.4
9.0
139.34
139.43
mmol/l
0.21
165
1444
33
183
1.96
2.87
12.0
5.0
0.18
0.96
mmol/l
0.92
23
128
5
6
8.51
2.76
10.6
7.0
—
—
—
0
0
33
187
1.92
2.70
12.8
5.0
5.11
5.00
kpa
0.47
33
180
18
82
2.31
2.56
1.7
1.5
—
—
—
0
0
89
679
1.56
2.44
4.1
2.9
72.19
64.89
nmol/l
1.39
84
633
19
92
2.18
2.36
2.6
6.3
4.06
3.11
g/l
0.95
19
87
10
34
3.04
2.31
1.3
1.1
—
—
—
0
0
10
34
3.04
2.31
1.3
1.1
—
—
—
0
0
55
379
1.62
2.30
5.3
2.3
—
—
—
0
0
11
41
2.78
2.24
1.7
1.1
—
—
—
0
0
15
67
2.34
2.24
3.2
1.6
—
—
—
0
0
11
42
2.71
2.18
1.7
1.1
—
—
—
0
0
30
178
1.81
2.14
5.5
4.2
6.12
6.87
umol/l
0.10
22
139
34
212
1.73
2.06
19.4
9.3
1.24
1.23
mmol/l
0.04
34
201
115
953
1.49
2.02
9.1
5.1
91.60
83.69
u/l
0.58
107
892
19
99
2.02
1.98
2.7
6.6
105.16
93.68
%
1.72
19
99
8
27
3.04
1.96
1.0
1.1
—
—
—
0
0
67
500
1.51
1.95
6.3
3.4
—
—
—
0
0
66
491
1.51
1.95
3.2
3.2
28.67
27.80
u/l
0.11
60
472
5
12
4.24
1.83
1.0
2.1
—
—
—
0
0
5
12
4.24
1.83
1.0
2.1
—
—
—
0
0
7
24
2.98
1.74
1.1
1.7
—
—
—
0
0
26
159
1.73
1.69
12.5
4.6
9.93
9.79
kpa
0.16
26
153
31
200
1.65
1.67
21.0
6.6
23.90
23.53
mmol/l
0.38
31
200
12
56
2.22
1.64
1.8
1.6
—
—
—
0
0
14
71
2.05
1.58
2.6
1.7
—
—
—
0
0
18
104
1.80
1.42
1.7
1.6
199.27
183.05
u/ml
0.15
11
51
57
438
1.42
1.39
5.3
3.0
0.57
0.26
e6/l
0.50
45
295
42
305
1.48
1.37
2.3
3.0
0.89
1.31
mg/l
0.55
31
205
178
1666
1.65
1.36
15.3
9.7
20.34
21.47
mg/l
0.18
143
1260
116
1008
1.36
1.32
12.4
8.0
4.09
3.81
e9/l
0.69
104
847
135
1208
1.37
1.24
11.1
6.5
109.38
109.62
ml/min/173m2
0.04
114
984
137
1235
1.35
1.15
3.8
2.6
5.50
5.37
mmol/l
0.72
131
1129
0
36
0.00
1.15
0.0
1.1
—
—
—
0
0
11
58
1.95
1.14
2.0
1.9
—
—
—
0
0
25
170
1.54
1.11
1.8
1.8
—
—
—
0
0
193
1868
2.10
1.09
22.9
15.0
4.54
4.55
e12/l
0.13
184
1814
193
1865
2.16
1.08
23.0
15.1
277.58
267.89
e9/l
1.19
185
1814
57
457
1.35
1.06
3.4
3.1
0.00
0.01
estimate
0.50
25
185
19
123
1.60
1.04
1.5
1.6
—
—
—
0
0
7
34
2.10
1.04
1.4
1.2
—
—
—
0
0
148
1361
1.34
1.01
5.4
4.1
14.24
14.33
pmol/l
0.20
142
1235
23
158
1.52
0.99
1.3
1.3
209.99
429.59
u/ml
0.62
23
149
28
202
1.45
0.96
1.5
1.3
44.41
143.16
u/ml
—
9
68
18
118
1.58
0.94
1.4
1.5
—
—
—
0
0
6
28
2.18
0.92
1.3
1.6
—
—
—
0
0
18
119
1.56
0.92
3.6
3.0
5.22
4.93
pmol/l
0.75
18
108
85
737
1.27
0.87
5.0
3.0
—
—
estimate
—
0
0
54
442
1.30
0.87
2.4
2.7
1.02
1.02
kg/l
0.59
34
276
18
121
1.54
0.86
1.4
1.3
—
—
—
0
0
8
45
1.81
0.85
1.8
3.0
1.03
0.49
nmol/l
—
8
39
35
270
1.36
0.84
1.9
2.2
21.74
11.15
ng/l
0.39
14
74
162
1526
1.33
0.81
5.9
4.8
2.38
1.75
mu/l
0.83
157
1453
12
74
1.66
0.80
5.3
1.9
0.28
0.17
e6/l
0.25
12
69
61
513
1.27
0.80
3.1
2.5
0.00
0.01
estimate
0.50
24
165
46
374
1.30
0.78
1.6
1.6
—
—
—
0
0
40
319
1.32
0.77
3.0
2.5
5487.24
5688.48
u/l
0.02
18
133
6
34
1.79
0.77
1.5
1.1
—
—
—
0
0
100
896
1.23
0.74
4.4
3.2
0.00
0.00
estimate
-0.00
25
188
100
897
1.23
0.73
4.4
3.3
0.00
0.00
estimate
-0.00
27
185
9
57
1.61
0.72
1.0
1.6
—
—
—
0
0
7
40
1.78
0.72
1.4
3.2
4.10
3.44
mmol/l
—
7
40
99
889
1.23
0.71
4.4
3.2
0.00
0.00
estimate
-0.00
25
190
24
179
1.39
0.71
1.5
1.2
—
—
—
0
0
7
43
1.65
0.67
1.0
1.1
—
—
—
0
0
7
43
1.65
0.67
7.4
22.9
22.76
24.05
mmol/l
—
7
43
7
43
1.65
0.67
1.9
1.6
—
—
—
0
0
113
1033
1.22
0.67
4.7
3.2
36.28
35.46
mmol/mol
0.35
105
987
7
44
1.61
0.66
1.4
3.3
603.00
329.45
mg/l
—
7
44
0
21
0.00
0.60
0.0
1.2
—
67.48
—
0
21
6
37
1.64
0.56
1.2
1.2
—
—
—
0
0
17
125
1.39
0.56
1.5
1.6
—
—
—
0
0
33
270
1.27
0.54
5.9
2.6
3.39
3.65
e6/l
0.07
15
110
9
132
0.67
0.54
1.1
1.2
0.62
4.09
u/ml
—
9
83
7
45
1.58
0.49
7.3
22.0
0.56
0.60
%
—
7
45
15
199
0.73
0.49
1.4
1.7
—
—
—
0
0
7
47
1.51
0.48
7.3
21.2
1.34
1.04
%
—
7
47
5
31
1.63
0.43
1.4
5.9
3.60
9.55
u/ml
—
5
31
72
654
1.16
0.41
3.2
2.8
0.09
0.01
estimate
0.39
23
153
5
33
1.53
0.41
1.6
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
95
881
1.15
0.41
2.4
2.2
—
—
—
0
0
14
106
1.35
0.40
1.6
1.5
—
—
—
0
0
162
1670
0.84
0.38
4.9
4.3
—
—
—
0
0
80
737
1.14
0.38
1.6
1.8
3.16
3.23
u/ml
0.01
19
167
6
47
1.29
0.32
1.5
1.1
—
—
—
0
0
51
461
1.14
0.31
1.8
1.6
93.98
95.05
pmol/l
0.08
30
251
50
454
1.14
0.29
2.0
1.7
1.32
1.25
mmol/l
0.33
44
415
13
160
0.80
0.27
1.7
1.6
55.96
57.03
ug/l
0.04
13
160
23
199
1.18
0.25
2.0
2.3
284.86
738.29
ng/l
—
7
79
24
274
0.86
0.24
1.3
1.4
—
—
—
0
0
5
38
1.32
0.23
3.4
2.3
—
—
—
0
0
5
38
1.32
0.23
3.6
2.2
—
—
—
0
0
5
39
1.29
0.23
1.0
1.8
6.46
6.93
mmol/l
—
5
39
31
278
1.14
0.22
5.5
2.6
0.59
1.06
e6/l
0.62
14
120
5
42
1.20
0.21
1.6
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
763.45
—
0
11
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
9
112
0.79
0.20
1.4
1.5
765.22
984.54
nmol/l
—
9
87
0
14
0.00
0.20
0.0
1.1
—
160.86
—
0
14
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
62
584
1.09
0.19
2.4
2.4
—
—
—
0
0
7
62
1.13
0.17
1.4
1.1
—
—
—
0
0
22
196
1.14
0.17
1.8
1.5
1.06
1.23
ratio
0.39
15
121
22
196
1.14
0.17
1.8
1.5
1.34
1.17
ratio
0.24
15
121
22
196
1.14
0.17
1.8
1.5
0.84
0.94
ratio
0.96
15
121
54
508
1.09
0.17
1.9
2.2
—
—
—
0
0
106
1025
1.07
0.16
4.8
3.3
28.95
25.41
u/l
0.56
101
988
21
188
1.13
0.15
1.6
1.5
—
—
—
0
0
9
82
1.10
0.15
2.0
1.5
—
—
—
0
0
7
85
0.82
0.15
2.0
2.7
—
—
—
0
0
16
179
0.88
0.13
1.9
1.8
—
—
—
0
0
24
220
1.10
0.12
1.1
1.1
—
—
—
0
0
53
506
1.06
0.11
3.3
2.7
2.48
2.30
mg/l
0.35
44
440
20
218
0.91
0.10
1.2
1.4
3.30
3.26
ratio
—
10
149
10
87
1.16
0.09
1.6
2.1
—
—
—
0
0
8
76
1.05
0.07
1.0
1.1
—
14.77
—
0
19
16
173
0.92
0.07
1.1
1.4
3.17
3.15
mmol/l
—
7
108
15
162
0.92
0.06
1.7
1.4
158.56
277.10
miu/ml
—
9
89
12
111
1.09
0.04
3.0
3.2
3.23
6.60
umol/l
—
6
88
120
1212
0.98
0.03
3.9
2.8
1.35
1.44
mmol/l
1.91
115
1164
11
102
1.08
0.03
3.0
1.7
—
—
—
0
0
112
1111
1.02
0.02
5.6
3.3
50.75
47.28
ug/l
0.17
105
1052
72
728
0.98
0.01
2.3
2.5
—
—
—
0
0
10
106
0.94
0.01
1.1
1.3
—
—
—
0
0
78
775
1.01
0.00
2.6
2.7
—
—
—
0
0
23
235
0.98
0.00
1.1
1.2
1.11
5.89
u/ml
—
9
88
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
1.42
—
0
8
0
6
0.00
0.00
0.0
1.0
—
0.06
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
5.3
—
5.52
—
0
6
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
5
55
0.91
-0.00
1.4
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
7
74
0.94
-0.00
1.1
1.3
—
—
—
0
0
11
110
1.00
-0.00
2.1
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
26
260
1.00
-0.00
1.1
1.3
11.13
13.98
iu/ml
—
8
50
9
95
0.94
-0.00
1.1
1.2
—
6.94
—
0
8
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.1
—
3.02
—
0
8
0
7
0.00
-0.00
0.0
2.4
—
2.80
—
0
7
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_PREPUB and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_PREPUB.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_PREPUB – Precocious puberty
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data