No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4780 |
4. Check minimum number of eventsNone |
4780 |
5. Include endpointsNone |
4780 |
6. Filter based on genotype QC (FinnGen only) |
4780 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E87
- Name in latin
- Hypokalaemia
Similar endpoints
↥List of similar endpoints to
Hypokalaemia
based on the number of shared cases.
Similar with more cases:
- Other disorders of fluid, electrolyte and acid-base balance
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 44509 | 28754 | 15405 |
Only index persons | 37186 | 24295 | 12891 |
Unadjusted period prevalence (%) | |||
Whole population | 0.68 | 0.82 | 0.43 |
Only index persons | 0.75 | 0.89 | 0.49 |
Median age at first event (years) | |||
Whole population | 68.02 | 70.70 | 63.06 |
Only index persons | 67.64 | 70.04 | 63.12 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 4780 | 2992 | 1788 |
Unadjusted period prevalence (%) | 0.93 | 1.02 | 0.79 |
Median age at first event (years) | 64.85 | 63.92 | 66.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 4218
- Matched controls
- 42180
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPOKALAEMIA and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
E4_HYPOKALAEMIA | 2.339 [2.11, 2.59] | < 0.001 |
Birth year | 0.997 [0.99, 1.0] | 0.411 |
During the follow-up period (1.1.1998 — 31.12.2019), 8934 out of 20756 females with E4_HYPOKALAEMIA died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
E4_HYPOKALAEMIA | 4.304 [3.73, 4.97] | < 0.001 |
Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 5287 out of 11180 males with E4_HYPOKALAEMIA died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPOKALAEMIA.N-year risk | Females | Males |
---|---|---|
1 | 0.275% | 0.845% |
5 | 1.248% | 4.493% |
10 | 3.163% | 11.026% |
15 | 6.378% | 20.024% |
20 | 11.442% | 31.02% |
Relationships between endpoints
↥Index endpoint: E4_HYPOKALAEMIA – Hypokalaemia
GWS hits: -