No definition available.
Hereditary deficiency of other clotting factors
DOID EFO Endpoint Browser PheWeb
D3_HEREDOTHCLOFACTORS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
383 |
4. Check minimum number of eventsNone |
383 |
5. Include endpointsNone |
383 |
6. Filter based on genotype QC (FinnGen only) |
339 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D68
- Name in latin
- Deficientia hereditaria aliorum factorum coagulationis
Similar endpoints
↥List of similar endpoints to
Hereditary deficiency of other clotting factors
based on the number of shared cases.
Similar with more cases:
- Other coagulation defects
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2150 | 1552 | 590 |
| Only index persons | 2039 | 1500 | 539 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 36.75 | 32.72 | 47.34 |
| Only index persons | 36.81 | 32.79 | 47.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 339 | 241 | 98 |
| Unadjusted period prevalence (%) | 0.07 | 0.09 | 0.04 |
| Median age at first event (years) | 42.75 | 36.65 | 57.74 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 353
- Matched controls
- 3530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D68.2
ICD-10 Finland
Hereditary deficiency of other clotting factors
+∞
307.7
349
*
D68.8
ICD-10 Finland
Other specified coagulation defects
764.9
154.3
141
*
B01AA03
ATC
warfarin; systemic
11.7
110.6
149
208
B01AB05
ATC
enoxaparin; parenteral
8.3
88.3
227
630
B01AB04
ATC
dalteparin; parenteral
14.7
79.2
78
67
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
15.4
71.2
67
53
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
20.2
57.7
46
26
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
96.9
46.2
50
6
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
5.5
36.4
84
191
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
8.8
35.8
48
62
I80.29
ICD-10 Finland
Phlebitis and thrombophlebitis of other deep vessels of lower extremities
10.8
34.5
39
40
D68.9
ICD-10 Finland
Coagulation defect, unspecified
268.2
25.0
25
*
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
3.6
19.8
77
254
D68.0
ICD-10 Finland
Von Willebrand disease
+∞
16.8
16
*
I82.88
ICD-10 Finland
Embolism and thrombosis of other specified veins
17.1
15.5
24
15
K94
ICPC
Phlebitis/thrombophlebitis
16.3
14.6
23
15
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
37.8
14.6
18
5
N02AX02
ATC
tramadol; systemic, rectal
2.4
14.5
172
1002
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.2
14.0
40
105
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.4
13.8
169
991
B01AB10
ATC
tinzaparin; parenteral
3.3
13.6
56
189
I82.9
ICD-10 Finland
Embolism and thrombosis of unspecified vein
12.9
13.3
23
19
O28.0
ICD-10 Finland
Abnormal haematological finding on antenatal screening of mother
72.5
12.7
14
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.2
11.2
49
171
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
4.6
11.2
27
62
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.9
10.9
58
227
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
10.6
104
545
I80.9
ICD-10 Finland
Phlebitis and thrombophlebitis of unspecified site
15.2
10.1
16
11
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
2.8
9.5
50
194
I87.0
ICD-10 Finland
Postthrombotic syndrome
31.0
9.5
12
*
D68.4
ICD-10 Finland
Acquired coagulation factor deficiency
+∞
9.4
9
*
A46
ICD-10 Finland
Erysipelas
2.6
9.1
56
236
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
9.0
64
289
I80.20
ICD-10 Finland
Phlebitis and thrombophlebitis in the iliac vein
24.8
9.0
12
5
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
4.7
9.0
21
47
R07.4
ICD-10 Finland
Chest pain, unspecified
2.1
8.8
105
588
4511A
ICD-9 Finland
Phlebitis and thrombophlebitis, Of deep vessels of lower extremities
20.6
8.5
12
6
126
Kela drug reimbursment
Chronic coagulation defects
+∞
8.4
8
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.0
8.2
24
64
B01AF01
ATC
rivaroxaban; oral
2.7
8.0
46
186
I80.1
ICD-10 Finland
Phlebitis and thrombophlebitis of femoral vein
13.4
7.9
13
10
M79.6
ICD-10 Finland
Pain in limb
1.9
7.8
175
1211
K99
ICPC
Cardiovascular disease other
9.2
7.6
15
17
L17
ICPC
Foot/toe symptom/complaint
1.9
7.5
118
724
R60.0
ICD-10 Finland
Localized oedema
2.5
7.5
49
212
R06.0
ICD-10 Finland
Dyspnoea
2.0
7.5
101
589
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.2
7.4
73
377
NA1AD
NOMESCO Finland
Cervical spine CT examination
3.4
7.0
25
77
R4110
NOMESCO Finland
Physiotherapy
1.9
7.0
106
642
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
6.9
6.9
16
24
N03AX16
ATC
[U] pregabalin
2.0
6.8
80
442
45100
ICD-8 Finland
Phlebitis and thrombophlebitis, Of lower extremities
40.9
6.8
8
*
R42
ICD-10 Finland
Dizziness and giddiness
2.0
6.8
80
443
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.9
6.7
31
112
I80.8
ICD-10 Finland
Phlebitis and thrombophlebitis of other sites
7.1
6.6
15
22
E0000UV, ,
ATC
1.8
6.5
157
1093
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
6.5
153
1059
H02AB06
ATC
prednisolone; systemic
1.8
6.4
168
1196
AA1AD
NOMESCO Finland
CT of head and brain
1.9
6.4
90
528
N02AJ06
ATC
codeine and paracetamol; systemic
1.8
6.4
164
1160
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
6.3
79
445
XF400
NOMESCO Finland
ECG with 12 standard connections
2.3
6.3
52
249
K84
ICPC
Heart disease other
7.2
6.3
14
20
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
7.2
6.3
14
20
D68
ICD-10 Finland
Other coagulation defects
+∞
6.3
6
*
K14.1
ICD-10 Finland
Geographic tongue
+∞
6.3
6
*
A02BC02
ATC
pantoprazole; systemic
1.8
6.2
232
1824
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.8
6.0
121
794
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
134
381
5.06
45.45
5.6
2.1
33.98
29.40
s
1.96
127
376
180
708
4.15
38.64
4.4
1.8
0.87
0.98
mg/l
0.24
131
555
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
49
62
9.02
37.16
6.8
3.5
0.35
0.38
iu/ml
0.20
26
37
237
1173
4.11
35.53
42.9
10.5
1.66
1.17
inr
18.24
207
967
30
5
65.30
26.42
6.8
1.2
136.70
155.20
%
—
30
5
36
53
7.45
23.81
1.1
1.1
—
—
—
0
0
32
53
6.54
18.92
1.5
1.2
1.82
4.71
u/ml
0.40
11
21
31
54
6.20
17.43
1.5
1.2
3.50
4.52
u/ml
0.22
16
23
106
468
2.81
16.30
5.6
3.4
0.80
0.82
mmol/l
0.86
101
447
203
1234
2.52
16.01
7.6
4.9
36.41
36.51
g/l
0.09
189
1175
194
1231
2.28
12.89
12.8
7.1
1.21
1.22
mmol/l
0.69
184
1148
210
1396
2.24
12.21
9.8
7.6
1.21
1.21
mmol/l
0.21
184
1229
100
495
2.42
11.71
4.4
2.6
13.85
13.55
umol/l
0.18
95
463
87
419
2.43
10.73
4.8
2.6
23.35
23.06
%
0.09
82
397
292
2292
2.59
10.67
9.7
7.5
74.18
77.55
u/l
0.63
280
2179
232
1684
2.10
9.81
8.1
5.0
6.35
6.43
mmol/l
0.19
226
1576
243
1838
2.03
8.62
9.5
9.1
4.07
4.03
e9/l
0.12
221
1603
131
807
1.99
8.44
3.5
2.1
2.57
2.67
mg/l
0.21
111
712
53
226
2.58
8.35
3.3
2.7
77.91
70.95
ml/min/173m2
0.75
34
94
121
732
1.99
8.16
3.5
2.1
—
—
—
0
0
212
1563
1.89
7.71
6.8
6.0
9.93
11.03
umol/l
1.11
203
1500
154
1034
1.87
7.45
3.9
3.0
2.33
2.35
mmol/l
1.85
139
954
58
278
2.30
7.06
3.6
4.2
216.84
231.33
u/l
0.78
51
272
94
544
1.99
7.05
4.1
2.5
2.40
2.44
mmol/l
2.86
85
485
88
509
1.97
6.57
4.1
3.4
287.69
301.24
ng/l
0.03
62
341
6
0
+∞
6.27
1.0
0.0
—
—
—
0
0
196
1466
1.76
6.26
3.7
2.7
—
—
estimate
—
0
0
337
3031
3.47
6.22
25.1
14.8
3.94
3.94
mmol/l
0.10
332
2964
336
3027
3.28
5.97
25.4
14.7
139.66
139.68
mmol/l
0.08
331
2971
66
357
2.04
5.90
13.5
7.1
104.95
104.61
mmol/l
0.32
66
357
158
1127
1.73
5.86
4.0
3.2
26.37
29.64
u/l
1.61
149
1083
186
1389
1.72
5.82
3.3
2.6
74.87
74.39
nmol/l
0.09
177
1281
110
714
1.79
5.63
3.1
3.3
1395.46
1053.86
ng/l
0.40
83
597
324
2891
2.47
5.41
20.5
12.2
86.68
87.59
ml/min/173m2
0.31
298
2634
12
18
6.86
5.30
1.3
1.2
—
—
—
0
0
141
1002
1.68
5.13
3.9
3.5
20.80
95.40
ng/l
0.57
84
593
216
1717
1.66
5.05
4.9
3.3
89.62
89.57
ug/l
0.00
206
1631
74
451
1.81
4.59
3.4
2.7
4.08
2.63
e6/l
0.57
36
213
131
938
1.63
4.50
2.4
2.5
58.56
60.85
u/l
0.10
123
891
115
809
1.63
4.20
4.2
2.7
0.25
0.32
e6/l
0.28
86
568
271
2336
1.69
4.16
6.0
4.0
10.39
10.16
mm/h
0.12
260
2204
14
37
3.90
3.94
1.1
1.2
—
—
—
0
0
13
33
4.05
3.83
1.1
1.2
—
—
—
0
0
101
704
1.61
3.77
1.4
1.3
24.72
27.22
iu/ml
0.09
28
214
13
34
3.93
3.73
1.1
1.2
—
—
—
0
0
13
34
3.93
3.73
1.1
1.2
—
—
—
0
0
13
34
3.93
3.73
1.1
1.2
—
—
—
0
0
158
1223
1.53
3.71
2.4
2.0
98.00
96.37
pmol/l
0.17
102
659
14
40
3.60
3.65
1.1
1.2
—
—
—
0
0
17
62
2.83
3.64
5.2
4.5
10.39
2.24
ratio
—
10
34
342
3217
3.03
3.54
15.3
10.6
24.79
25.50
u/l
0.48
335
3150
281
2489
1.63
3.40
5.6
4.6
14.59
14.47
pmol/l
0.43
263
2333
31
156
2.08
3.36
1.8
1.9
3.82
4.60
iu/ml
—
6
33
52
313
1.78
3.34
2.0
1.7
—
—
—
0
0
22
96
2.38
3.34
1.4
2.1
1.24
1.48
g/l
0.69
17
88
73
483
1.64
3.33
3.5
2.6
0.67
0.92
e6/l
0.72
35
244
68
442
1.67
3.32
2.0
1.8
—
—
—
0
0
331
3082
2.19
3.27
22.9
13.2
19.37
20.75
mg/l
0.40
284
2478
110
805
1.53
3.27
1.8
1.6
19.27
21.54
nmol/l
0.82
95
697
45
263
1.81
3.18
17.8
10.7
1.35
1.03
mmol/l
0.26
38
217
11
31
3.63
3.01
1.4
1.1
—
—
—
0
0
316
2911
1.82
3.01
6.8
5.4
1.84
1.80
mu/l
0.28
298
2752
45
268
1.78
3.00
3.7
3.0
—
—
—
0
0
16
63
2.61
3.00
1.6
1.3
294.70
171.60
u/ml
—
10
36
28
142
2.06
2.99
2.0
1.6
—
—
—
0
0
89
637
1.53
2.89
1.3
1.3
17.47
7.06
u/ml
0.51
31
254
62
409
1.63
2.85
1.7
1.6
1221.28
1188.40
nmol/l
0.09
47
314
18
79
2.35
2.72
1.3
1.3
—
—
—
0
0
39
230
1.78
2.70
2.1
2.1
1337.55
4710.82
u/l
1.27
17
99
48
301
1.69
2.68
2.1
1.8
—
—
—
0
0
10
30
3.40
2.62
7.8
16.9
6.57
6.73
mmol/l
—
10
23
37
217
1.79
2.61
1.6
1.4
—
—
—
0
0
18
81
2.29
2.58
1.8
2.6
—
—
—
0
0
197
1670
1.41
2.56
4.3
3.5
0.00
8.75
estimate
0.80
56
358
5
7
7.22
2.55
1.2
1.0
94.20
83.14
%
—
5
7
195
1657
1.40
2.46
4.3
3.4
0.00
0.00
estimate
0.50
56
352
18
83
2.23
2.45
1.8
1.4
339.90
332.44
ug/g
0.04
12
48
45
285
1.66
2.43
4.8
3.6
6.21
5.69
kpa
1.69
45
277
22
111
2.05
2.41
2.0
2.0
3.02
4.07
iu/l
—
10
44
97
736
1.44
2.33
3.0
2.6
334.95
326.62
umol/l
0.37
87
676
37
226
1.71
2.29
16.9
8.5
8.37
8.48
mmol/l
0.04
37
216
10
35
2.91
2.22
1.0
1.2
—
—
—
0
0
5
9
5.62
2.22
1.0
3.3
0.61
0.63
mmol/l
—
5
9
53
360
1.56
2.17
3.8
2.7
7.97
6.60
umol/l
0.18
44
315
151
1251
1.36
2.13
2.2
1.9
1.42
1.36
mmol/l
0.35
130
1082
195
1682
1.36
2.11
4.4
3.5
0.00
0.01
estimate
0.50
52
341
39
249
1.64
2.06
4.4
3.3
4.00
4.72
kpa
2.32
39
244
12
50
2.45
2.04
1.3
1.4
—
—
—
0
0
8
26
3.12
2.02
2.4
3.0
—
—
—
0
0
40
259
1.61
2.00
3.1
4.3
2.34
8.16
ug/l
2.18
28
205
10
39
2.61
1.95
1.0
1.0
—
—
—
0
0
5
11
4.59
1.94
2.6
1.7
39.60
65.25
ug/l
—
5
11
5
11
4.59
1.94
2.2
3.7
412.40
560.91
u/ml
—
5
11
8
27
3.01
1.94
1.3
1.7
—
—
—
0
0
12
52
2.35
1.90
1.3
1.4
—
—
—
0
0
12
52
2.35
1.90
1.3
1.4
—
—
—
0
0
7
22
3.22
1.89
1.1
1.1
16.86
7.27
mm/h
—
7
22
11
46
2.44
1.87
1.5
1.0
—
—
—
0
0
47
322
1.53
1.86
5.0
4.4
32.94
31.95
%
0.22
33
228
30
184
1.69
1.85
1.9
1.6
—
—
—
0
0
112
903
1.35
1.84
4.7
3.4
0.00
0.01
estimate
0.80
51
332
9
35
2.61
1.81
2.0
1.3
—
—
—
0
0
17
88
1.98
1.78
15.3
5.2
8.39
8.55
kpa
0.16
17
88
346
3368
2.38
1.71
34.3
20.5
4.49
4.51
e12/l
0.40
341
3316
254
2318
1.34
1.70
4.0
3.6
—
—
—
0
0
118
970
1.33
1.68
3.7
2.9
0.00
0.03
estimate
1.34
46
288
109
886
1.33
1.68
1.6
1.3
0.65
2.06
u/ml
1.52
33
257
6
19
3.19
1.67
1.0
1.0
—
—
—
0
0
25
152
1.69
1.61
1.8
1.4
0.30
0.32
mg/l
—
8
69
8
32
2.53
1.60
1.1
1.3
—
—
—
0
0
14
71
2.01
1.56
2.1
1.6
—
—
—
0
0
8
33
2.46
1.54
1.1
1.2
—
—
—
0
0
8
33
2.46
1.54
1.1
1.2
—
—
—
0
0
6
21
2.89
1.51
1.0
1.0
—
—
—
0
0
9
39
2.34
1.44
1.6
1.7
—
—
—
0
0
58
440
1.38
1.38
1.6
1.8
1.52
1.39
%
0.33
48
397
44
319
1.43
1.36
1.2
1.2
168.67
138.61
u/ml
0.15
15
128
26
169
1.58
1.33
10.9
4.6
1.64
1.32
mmol/l
0.37
19
129
8
34
2.38
1.30
1.1
1.2
—
—
—
0
0
8
34
2.38
1.30
1.1
1.2
—
—
—
0
0
8
34
2.38
1.30
1.1
1.2
—
—
—
0
0
8
34
2.38
1.30
1.3
1.5
—
—
—
0
0
5
18
2.80
1.29
1.0
1.3
—
—
—
0
0
9
45
2.03
1.24
1.2
1.6
—
—
—
0
0
22
140
1.61
1.23
1.9
1.5
—
—
—
0
0
5
19
2.65
1.22
1.2
1.1
1906.80
1438.16
miu/ml
—
5
19
5
19
2.65
1.22
1.0
1.3
225.80
191.17
iu/ml
—
5
19
239
2210
1.25
1.18
4.7
3.2
47.60
39.93
u/l
0.59
225
2126
146
1284
1.23
1.14
4.2
3.3
0.00
0.04
estimate
1.47
47
296
292
2771
1.31
1.13
6.5
5.6
38.53
38.31
mmol/mol
0.14
272
2642
69
563
1.28
1.02
1.8
1.7
448.57
39920591.59
pmol/l
0.79
53
501
9
48
1.90
1.01
1.8
1.5
—
—
—
0
0
11
61
1.83
0.99
8.5
3.1
15.99
8.44
pmol/l
0.60
11
61
9
49
1.86
0.99
1.0
1.8
—
—
—
0
0
29
210
1.42
0.94
1.0
1.0
—
—
—
0
0
10
55
1.84
0.93
1.1
1.1
—
—
—
0
0
13
79
1.67
0.89
1.2
1.5
—
—
—
0
0
310
2988
1.31
0.88
5.8
4.6
4.61
4.71
mmol/l
0.89
292
2848
6
31
1.95
0.84
1.2
1.2
119.17
114.03
pmol/l
—
6
31
6
32
1.89
0.82
1.0
1.5
—
—
—
0
0
8
47
1.72
0.81
1.6
1.5
7.00
7.42
mmol/l
—
8
40
308
2977
1.27
0.77
5.8
4.5
1.41
1.48
mmol/l
2.31
290
2822
26
193
1.37
0.75
1.2
1.4
—
—
—
0
0
21
150
1.43
0.75
3.2
3.3
0.55
0.60
%
0.41
21
150
96
841
1.19
0.75
5.8
4.0
12.65
10.65
mg/mmol
0.16
64
541
70
595
1.22
0.74
2.4
2.1
—
—
—
0
0
312
3023
1.28
0.74
6.3
5.1
2.72
2.79
mmol/l
0.72
293
2870
14
92
1.54
0.73
5.6
3.1
25.02
24.02
mmol/l
0.83
14
92
7
39
1.81
0.73
1.0
1.2
—
—
—
0
0
22
160
1.40
0.72
1.8
1.5
—
—
—
0
0
294
2835
1.22
0.70
5.0
3.9
1.33
1.24
mmol/l
0.48
279
2674
12
77
1.58
0.69
1.2
1.5
—
—
—
0
0
21
153
1.40
0.69
3.2
3.3
0.96
1.23
%
1.44
21
153
5
27
1.86
0.68
1.0
1.0
—
—
—
0
0
10
62
1.63
0.65
1.1
1.1
—
—
—
0
0
5
29
1.73
0.64
1.2
1.7
12.10
28.42
ug/l
—
5
29
21
157
1.36
0.60
1.3
1.3
331.00
242.20
miu/ml
0.48
11
79
6
37
1.63
0.56
1.0
1.4
—
—
—
0
0
297
2883
1.19
0.55
5.1
4.5
5.80
5.77
mmol/l
0.17
275
2703
6
38
1.59
0.54
1.3
1.1
—
—
—
0
0
11
74
1.50
0.54
1.7
1.5
—
—
—
0
0
6
100
0.59
0.52
3.5
1.4
0.14
0.39
nmol/l
—
6
81
6
40
1.51
0.52
1.3
1.1
—
—
—
0
0
6
40
1.51
0.52
2.5
2.5
2.78
4.40
u/ml
—
6
40
11
75
1.48
0.51
1.2
1.4
—
—
—
0
0
7
46
1.53
0.48
1.1
1.5
—
—
—
0
0
17
129
1.33
0.46
1.1
1.3
—
—
—
0
0
10
139
0.71
0.42
1.3
1.2
0.88
0.88
g/l
—
10
139
8
60
1.34
0.40
1.1
1.4
—
—
—
0
0
38
326
1.19
0.40
1.3
1.4
21.15
21.51
iu/l
0.03
31
283
0
18
0.00
0.40
0.0
3.2
—
1.00
—
0
18
11
148
0.73
0.39
1.4
1.5
—
—
—
0
0
34
397
0.84
0.39
2.4
1.9
—
—
—
0
0
5
35
1.43
0.39
1.2
1.1
—
—
—
0
0
42
365
1.17
0.38
3.1
3.0
0.69
0.77
ug/l
0.22
25
231
10
136
0.73
0.38
1.3
1.1
1.54
1.57
g/l
—
10
136
9
124
0.72
0.35
1.9
1.8
—
—
—
0
0
6
42
1.44
0.35
1.0
1.1
—
—
—
0
0
10
73
1.38
0.35
1.1
1.2
—
—
—
0
0
79
729
1.11
0.31
4.2
3.3
1.02
1.02
kg/l
0.04
59
455
28
322
0.86
0.29
2.2
1.7
—
—
—
0
0
76
818
0.91
0.28
1.8
1.7
—
—
—
0
0
8
66
1.22
0.27
1.4
1.2
—
—
—
0
0
13
160
0.81
0.26
1.5
1.8
5.23
2.83
mg/l
—
8
121
9
74
1.22
0.25
1.6
1.3
—
—
—
0
0
12
96
1.26
0.25
1.2
1.2
—
—
—
0
0
12
147
0.81
0.24
1.8
1.6
—
—
—
0
0
12
97
1.25
0.23
1.2
1.2
—
—
—
0
0
59
548
1.09
0.21
2.4
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
2.61
—
0
6
0
11
0.00
0.21
0.0
2.7
—
11.41
—
0
11
0
11
0.00
0.21
0.0
2.7
—
4.40
—
0
11
0
10
0.00
0.21
0.0
1.0
—
0.01
—
0
5
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
35
320
1.10
0.18
1.7
1.7
3.42
3.48
mmol/l
0.10
18
233
14
120
1.17
0.16
1.2
1.3
—
—
—
0
0
26
285
0.91
0.15
1.5
1.6
692.25
1061.23
mu/l
1.94
20
232
7
86
0.81
0.14
1.4
1.5
3.17
3.69
mmol/l
—
7
80
9
109
0.82
0.13
1.1
1.3
54.56
101.88
pmol/l
—
9
104
9
110
0.81
0.13
1.3
1.5
64.17
55.37
ug/l
—
9
110
75
720
1.05
0.12
1.8
1.5
—
—
—
0
0
13
114
1.15
0.12
2.1
1.8
—
—
—
0
0
64
615
1.05
0.10
5.2
5.1
1.42
2.40
ug/l
1.14
54
556
5
46
1.09
0.09
1.2
1.4
—
—
—
0
0
5
63
0.79
0.08
1.8
2.0
—
—
—
0
0
7
65
1.08
0.08
1.1
1.4
—
—
—
0
0
15
138
1.09
0.06
1.9
1.6
—
—
—
0
0
18
192
0.93
0.05
1.4
1.5
—
—
—
0
0
14
151
0.92
0.05
1.5
1.5
1.86
1.17
ratio
—
5
93
14
151
0.92
0.05
1.5
1.5
1.05
1.23
ratio
—
5
93
14
151
0.92
0.05
1.5
1.5
1.00
0.96
ratio
—
5
93
14
150
0.93
0.04
1.5
1.5
—
—
—
0
0
13
139
0.93
0.03
3.2
3.2
1.02
1.02
ratio
1.00
13
131
17
161
1.06
0.03
1.4
1.6
75.81
61.05
ug/l
0.38
11
130
14
134
1.05
0.00
2.3
1.9
—
—
—
0
0
28
286
0.98
0.00
8.8
6.2
—
—
—
0
0
11
108
1.02
0.00
1.7
1.7
—
—
—
0
0
49
488
1.00
0.00
4.1
4.3
24.44
22.51
%
0.21
18
232
42
415
1.01
0.00
1.9
1.9
3.56
3.41
ratio
0.28
27
327
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
53.60
—
0
5
0
8
0.00
-0.00
0.0
1.6
—
1.27
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
0.02
—
0
6
5
53
0.94
-0.00
4.8
2.2
195.60
196.08
ug/min
—
5
29
0
7
0.00
-0.00
0.0
3.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
6.10
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_HEREDOTHCLOFACTORS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HEREDOTHCLOFACTORS | 1.209 [0.9, 1.63] | 0.215 |
| Birth year | 0.999 [0.99, 1.01] | 0.889 |
During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 1392 females with D3_HEREDOTHCLOFACTORS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HEREDOTHCLOFACTORS | 1.731 [1.28, 2.33] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 470 males with D3_HEREDOTHCLOFACTORS died.
Mortality risk
Mortality risk for people of age
years, who have D3_HEREDOTHCLOFACTORS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.131% | 0.313% |
| 5 | 0.801% | 2.019% |
| 10 | 2.02% | 4.984% |
| 15 | 3.777% | 8.99% |
| 20 | 6.841% | 15.016% |
Relationships between endpoints
↥Index endpoint: D3_HEREDOTHCLOFACTORS – Hereditary deficiency of other clotting factors
GWS hits: 13
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data