No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
224 |
4. Check minimum number of eventsNone |
224 |
5. Include endpoints |
224 |
6. Filter based on genotype QC (FinnGen only) |
224 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- P
- Name in latin
- Traumata intranatalia
Birth trauma
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9791 | 4219 | 5565 |
| Only index persons | 5628 | 2503 | 3125 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.12 | 0.16 |
| Only index persons | 0.11 | 0.09 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 0.05 | 0.04 | 0.02 |
| Only index persons | 0.05 | 0.05 | 0.04 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 224 | 131 | 93 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 1.89 | 2.86 | 0.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 200
- Matched controls
- 1998
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P14.0
ICD-10 Finland
Erb paralysis due to birth injury
+∞
111.1
96
*
P13.4
ICD-10 Finland
Fracture of clavicle due to birth injury
+∞
33.3
31
*
P12.0
ICD-10 Finland
Cephalhaematoma due to birth injury
+∞
14.8
14
*
P15.8
ICD-10 Finland
Other specified birth injuries
72.1
6.5
7
*
P15.2
ICD-10 Finland
Sternomastoid injury due to birth injury
+∞
6.3
6
*
7676A
ICD-9 Finland
Birth trauma, Injury to brachial plexus
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
143
1072
1.92
5.15
7.5
6.3
88.13
91.86
u/l
0.34
136
1001
30
131
2.49
4.60
1.6
1.6
255.00
335.80
mu/l
1.68
25
123
96
668
1.76
4.10
6.6
7.4
16.63
17.37
umol/l
0.07
89
631
28
130
2.32
3.77
2.7
2.1
9.50
12.10
nmol/l
0.76
22
116
76
505
1.76
3.74
7.5
7.1
36.62
37.15
g/l
0.33
71
480
133
1053
1.65
3.27
8.7
9.8
3.74
3.81
e9/l
0.13
120
903
143
1155
1.66
3.23
4.7
3.8
8.78
8.21
mm/h
0.23
130
1070
54
343
1.76
3.04
2.5
3.0
18.96
19.85
ng/l
0.07
30
157
5
5
10.18
2.99
1.0
1.6
—
—
—
0
0
27
137
2.10
2.95
1.9
1.6
1184.56
1083.12
nmol/l
0.21
16
106
112
870
1.57
2.83
6.2
7.1
5.96
6.16
mmol/l
0.59
103
785
34
202
1.81
2.38
3.4
2.9
12.61
14.31
umol/l
0.68
34
192
98
761
1.51
2.37
5.8
4.7
0.00
0.00
estimate
0.00
24
152
11
41
2.77
2.31
1.2
1.1
—
—
—
0
0
23
121
2.00
2.31
1.6
2.0
11.29
15.91
iu/l
0.39
17
92
99
774
1.50
2.30
4.3
3.4
0.00
0.00
estimate
0.00
22
143
32
189
1.81
2.29
3.5
2.8
2.33
2.57
g/l
1.46
32
175
173
1522
1.60
2.27
5.1
4.0
1.70
1.94
mu/l
2.77
165
1417
151
1291
1.52
2.24
3.5
3.0
5.50
5.52
mmol/l
0.08
139
1191
5
9
5.65
2.22
1.0
2.2
85.40
109.78
%
—
5
9
98
769
1.49
2.21
4.3
3.3
0.00
0.00
estimate
0.00
23
146
77
577
1.51
2.17
3.9
3.2
—
—
—
0
0
68
504
1.50
2.00
5.5
4.1
—
—
—
0
0
18
94
1.99
1.86
1.6
1.7
—
—
—
0
0
179
1613
1.55
1.85
15.6
12.5
139.74
139.56
mmol/l
0.58
170
1564
6
17
3.60
1.85
1.5
1.5
—
—
—
0
0
6
17
3.60
1.85
1.5
1.5
—
—
—
0
0
6
17
3.60
1.85
1.5
1.5
—
—
—
0
0
6
17
3.60
1.85
1.5
1.5
—
—
—
0
0
5
12
4.23
1.83
1.0
1.3
—
93.50
—
0
6
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
5
12
4.23
1.83
1.0
1.3
84.80
127.25
%
—
5
12
14
67
2.16
1.80
1.7
1.8
—
—
—
0
0
179
1618
1.53
1.77
15.6
12.5
4.00
3.92
mmol/l
2.90
169
1562
6
18
3.39
1.76
1.5
1.4
—
—
—
0
0
6
18
3.39
1.76
1.5
1.4
—
—
—
0
0
5
13
3.91
1.72
1.0
1.0
—
90.86
—
0
7
34
224
1.61
1.67
1.8
2.0
—
—
—
0
0
36
241
1.59
1.66
11.2
9.6
1.09
1.31
mmol/l
0.15
28
181
8
32
2.55
1.61
4.4
6.1
83.00
91.38
%
—
8
32
8
32
2.55
1.61
1.6
1.3
—
—
—
0
0
81
644
1.40
1.60
11.3
12.3
1.22
1.23
mmol/l
0.17
73
597
20
115
1.81
1.58
1.8
2.1
5.03
6.99
u/l
1.48
15
88
58
435
1.45
1.58
5.1
3.8
0.26
0.26
e6/l
0.02
47
329
44
312
1.51
1.58
2.5
3.2
2.52
1.10
mg/l
0.38
37
227
29
187
1.63
1.55
5.9
6.1
4.69
8.52
umol/l
1.00
23
158
190
1755
1.54
1.53
10.1
8.2
26.04
25.78
u/l
0.07
185
1690
85
688
1.38
1.50
14.7
11.5
1.22
1.22
mmol/l
0.12
71
615
12
59
2.09
1.46
1.1
1.2
—
—
—
0
0
6
22
2.77
1.44
1.2
1.0
—
—
—
0
0
18
104
1.79
1.42
1.1
1.4
265.38
298.12
miu/ml
—
8
50
12
60
2.06
1.41
1.1
1.2
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
5
17
2.98
1.36
1.0
1.7
79.20
123.35
%
—
5
17
15
84
1.84
1.30
2.1
1.9
—
—
—
0
0
129
1131
1.33
1.30
4.9
3.6
37.50
37.33
mmol/mol
0.06
123
1072
16
92
1.80
1.29
1.5
1.6
—
—
—
0
0
9
44
2.09
1.28
1.3
1.2
—
—
—
0
0
192
1795
1.49
1.27
13.3
10.8
16.43
20.83
mg/l
1.37
145
1277
176
1623
1.39
1.23
16.8
14.1
13.25
13.23
%
0.11
171
1595
52
404
1.37
1.16
3.4
2.8
2.68
2.72
mg/l
0.07
46
354
5
20
2.53
1.15
1.4
1.1
—
—
—
0
0
24
161
1.55
1.12
1.9
2.2
2.41
2.43
mmol/l
0.33
19
140
14
81
1.78
1.12
2.1
2.0
160.33
170.15
u/ml
—
6
45
24
162
1.54
1.09
1.8
1.8
—
—
—
0
0
24
164
1.52
1.04
1.8
1.9
—
—
—
0
0
9
48
1.91
1.02
1.3
1.2
—
—
—
0
0
9
48
1.91
1.02
1.7
2.0
—
—
—
0
0
9
48
1.91
1.02
7.3
9.5
—
748.13
—
0
8
32
234
1.43
1.01
11.3
14.9
24.35
24.90
mmol/l
0.52
32
234
7
35
2.03
1.01
2.4
1.3
—
—
—
0
0
30
217
1.44
1.00
5.9
11.7
1.11
1.32
mmol/l
0.12
23
161
145
1323
1.27
0.94
4.2
3.5
14.82
14.42
pmol/l
1.29
136
1194
9
52
1.76
0.93
1.8
2.1
—
—
—
0
0
50
400
1.32
0.92
5.4
3.6
0.00
0.01
estimate
0.50
23
145
119
1067
1.25
0.87
4.5
3.6
34.25
31.29
u/l
0.29
114
1020
18
121
1.53
0.86
3.3
5.8
—
—
—
0
0
6
31
1.96
0.85
1.0
1.1
—
—
—
0
0
26
190
1.42
0.83
1.8
1.6
477.05
39645443.82
pmol/l
0.50
21
169
8
46
1.77
0.83
1.3
1.7
0.19
0.38
nmol/l
—
8
37
143
1314
1.24
0.82
11.6
8.0
98.79
101.77
ml/min/173m2
0.70
109
961
11
66
1.70
0.80
10.4
21.9
95.68
95.23
%
0.24
11
66
8
48
1.69
0.79
4.0
2.6
142.63
131.68
g/l
—
8
38
0
27
0.00
0.78
0.0
1.2
—
22.38
—
0
19
14
91
1.57
0.77
1.4
1.3
—
—
—
0
0
12
75
1.63
0.76
2.5
1.4
—
—
—
0
0
38
301
1.32
0.76
1.8
2.0
—
—
—
0
0
143
1321
1.23
0.75
3.9
3.2
4.35
4.56
mmol/l
1.94
136
1253
7
38
1.87
0.74
1.4
1.7
—
—
—
0
0
5
25
2.02
0.73
2.4
2.0
—
—
—
0
0
143
1326
1.22
0.70
3.8
3.3
2.64
2.77
mmol/l
1.05
135
1249
30
233
1.33
0.69
5.8
3.8
10.27
83.02
mg/mmol
0.54
24
164
35
279
1.30
0.68
2.1
1.6
1.33
1.40
%
0.39
30
253
36
290
1.29
0.65
1.6
1.4
—
—
—
0
0
5
29
1.74
0.64
1.2
2.3
—
—
—
0
0
6
102
0.58
0.64
1.2
1.6
—
—
—
0
0
0
20
0.00
0.60
0.0
3.2
—
—
—
0
0
24
185
1.33
0.59
2.2
2.7
11805.54
5444.86
u/l
0.30
11
58
210
2045
1.43
0.59
19.9
15.5
266.52
263.82
e9/l
0.22
203
1974
8
53
1.53
0.59
2.1
1.4
—
—
—
0
0
17
124
1.40
0.57
1.7
1.9
—
—
—
0
0
60
523
1.20
0.55
2.7
2.4
—
—
—
0
0
84
756
1.18
0.54
2.5
1.9
—
—
—
0
0
210
2049
1.40
0.53
19.8
15.5
4.62
4.60
e12/l
0.29
203
1978
9
64
1.42
0.52
2.2
2.1
—
99.89
—
0
9
14
101
1.41
0.51
4.4
2.6
—
—
—
0
0
134
1257
1.16
0.50
3.6
3.0
1.21
1.19
mmol/l
0.10
129
1189
63
558
1.18
0.48
2.9
2.6
—
—
—
0
0
10
68
1.49
0.48
1.8
1.3
—
—
—
0
0
185
1788
1.20
0.43
15.0
12.7
39.90
40.15
%
0.17
154
1534
5
31
1.63
0.43
1.8
1.8
—
—
—
0
0
6
93
0.64
0.43
2.2
1.7
—
—
—
0
0
5
33
1.53
0.41
2.4
3.9
56.40
50.76
%
—
5
33
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
2.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
76.00
—
0
17
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
5
34
1.48
0.40
1.2
1.8
—
—
—
0
0
0
18
0.00
0.40
0.0
1.9
—
—
—
0
0
0
18
0.00
0.40
0.0
1.9
—
—
—
0
0
17
133
1.30
0.40
3.7
1.8
—
—
—
0
0
27
225
1.23
0.39
3.9
3.2
54.68
656.28
ng/l
3.81
17
132
41
357
1.18
0.39
2.1
2.2
—
—
—
0
0
9
70
1.30
0.37
5.7
5.1
10.02
13.20
umol/l
—
9
58
9
71
1.28
0.36
10.6
20.5
1.07
1.34
%
—
9
71
72
659
1.14
0.36
4.7
4.4
—
—
—
0
0
6
43
1.41
0.35
2.0
2.0
—
—
—
0
0
6
45
1.34
0.34
1.2
2.1
—
—
—
0
0
7
96
0.72
0.31
1.7
1.5
—
—
—
0
0
11
84
1.33
0.30
1.9
2.0
—
—
—
0
0
13
161
0.80
0.28
1.5
1.5
—
—
—
0
0
9
72
1.26
0.26
12.4
20.2
0.61
0.72
%
—
9
72
44
399
1.13
0.25
2.1
1.7
90.88
95.65
pmol/l
0.34
31
226
5
42
1.19
0.21
1.2
1.3
—
21.82
—
0
9
5
42
1.19
0.21
1.4
1.5
3.84
15.22
u/l
—
5
37
0
11
0.00
0.21
0.0
1.0
—
2.07
—
0
5
0
10
0.00
0.21
0.0
1.0
—
3.24
—
0
5
0
10
0.00
0.21
0.0
10.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
5
43
1.17
0.21
1.2
1.4
—
—
—
0
0
5
43
1.17
0.21
1.2
1.4
—
—
—
0
0
21
183
1.16
0.21
1.3
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
1500.92
—
0
13
6
48
1.26
0.20
3.8
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
2.3
—
46.00
—
0
14
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
6
50
1.21
0.20
2.8
1.6
—
—
—
0
0
10
122
0.81
0.19
1.5
1.4
—
—
—
0
0
6
51
1.18
0.19
1.2
2.0
—
—
—
0
0
22
194
1.15
0.19
5.5
10.7
23.68
24.42
mmol/l
0.98
22
194
6
52
1.16
0.19
1.2
2.1
—
—
—
0
0
19
167
1.15
0.17
1.1
1.2
204.50
112.14
iu/ml
—
6
63
69
655
1.08
0.17
1.5
1.5
0.55
1.36
u/ml
2.12
14
131
177
1738
1.09
0.16
4.2
3.9
—
—
—
0
0
19
168
1.14
0.16
3.2
4.0
1.34
1.93
ug/l
0.79
19
149
9
83
1.09
0.15
1.1
1.5
—
—
—
0
0
8
98
0.81
0.14
1.3
1.2
—
—
—
0
0
35
328
1.08
0.12
3.1
2.8
—
—
—
0
0
20
182
1.11
0.11
1.0
1.0
—
—
—
0
0
21
228
0.91
0.10
1.2
1.3
1.83
7.73
u/ml
—
6
75
17
186
0.91
0.09
1.4
1.5
—
—
—
0
0
5
48
1.04
0.09
1.0
1.0
2.72
3.54
kpa
—
5
40
27
255
1.07
0.07
7.0
3.8
2.07
2.59
e6/l
0.20
18
143
7
81
0.86
0.07
1.7
1.4
—
—
—
0
0
7
81
0.86
0.07
1.7
1.4
—
—
—
0
0
7
81
0.86
0.07
1.7
1.4
—
—
—
0
0
9
87
1.04
0.07
1.4
1.3
—
—
—
0
0
25
248
1.01
0.00
1.3
1.3
12.91
23.95
iu/ml
—
7
74
27
268
1.01
0.00
4.8
3.3
0.63
0.70
e6/l
0.07
17
154
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
15.40
—
0
5
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
9.6
—
—
—
0
0
0
8
0.00
0.00
0.0
2.9
—
44.75
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
5
49
1.02
0.00
1.0
1.0
20.02
19.54
mmol/l
—
5
49
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
5.8
—
127.97
—
0
9
6
62
0.97
0.00
1.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
5
49
1.02
0.00
1.0
1.0
7.94
6.88
kpa
—
5
41
0
9
0.00
0.00
0.0
3.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint P16_BIRTH_TRAUMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| P16_BIRTH_TRAUMA | 1.543 [1.13, 2.11] | 0.007 |
| Birth year | 0.996 [0.99, 1.0] | 0.359 |
During the follow-up period (1.1.1998 — 31.12.2019), 53 out of 3961 females with P16_BIRTH_TRAUMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| P16_BIRTH_TRAUMA | 1.873 [1.45, 2.41] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 95 out of 5252 males with P16_BIRTH_TRAUMA died.
Mortality risk
Mortality risk for people of age
years, who have P16_BIRTH_TRAUMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.143% | 0.373% |
| 5 | 0.858% | 2.08% |
| 10 | 2.118% | 5.169% |
| 15 | 4.203% | 10.013% |
| 20 | 7.55% | 16.362% |
Relationships between endpoints
↥Index endpoint: P16_BIRTH_TRAUMA – Birth trauma
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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