Melanocytic naevi of upper limb, including shoulder

CD2_BENIGN_MELANOCYTIC_UPPERLIMB

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D22.6&
  • Hospital discharge: ICD-9 2166A
  • Cause of death: ICD-10 D22.6&
  • Cause of death: ICD-9 2166A

2 out of 7 registries used, show all original rules.

1033

4. Check minimum number of events

None

1033

5. Include endpoints

None

1033

6. Filter based on genotype QC (FinnGen only)

923

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D22
Name in latin
Naevus melanocyticus (cutis) regionis deltoideae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5751 3429 2304
Only index persons 5400 3265 2135
Unadjusted period prevalence (%)
Whole population 0.08 0.10 0.06
Only index persons 0.10 0.12 0.08
Median age at first event (years)
Whole population 41.00 39.84 42.75
Only index persons 41.93 40.42 44.24

-FinnGen-

Key figures

All Female Male
Number of individuals 923 606 317
Unadjusted period prevalence (%) 0.19 0.22 0.15
Median age at first event (years) 53.24 48.32 62.65

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
957
Matched controls
9570
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
61.2
307.7
331
82
D22.6
ICD-10 Finland
Melanocytic naevi of upper limb, including shoulder
4341.1
307.7
916
49
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
11.9
277.9
351
445
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
12.7
257.4
296
327
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
9.3
179.5
252
353
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
12.0
120.6
129
123
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
7.4
118.2
193
314
D22.7
ICD-10 Finland
Melanocytic naevi of lower limb, including hip
14.5
110.0
103
79
C43.52
ICD-10 Finland
Malignant melanoma on the torso: 'superficial spreading' type
26.8
103.4
72
29
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
7.1
102.1
171
284
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
6.0
100.3
204
411
L57.0
ICD-10 Finland
Actinic keratosis
5.3
93.7
224
520
XQ845
NOMESCO Finland
Dermatoscopy
14.2
91.5
86
66
XQ848
NOMESCO Finland
Dermatological photography
9.5
78.8
98
114
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
13.3
75.1
73
59
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
10.0
73.3
87
95
C43.62
ICD-10 Finland
Malignant melanoma of upper extremity including shoulder: 'superficial spreading' type
33.7
69.9
45
14
8720/3-C44.9
ICD-O-3
Malignant melanoma, NOS, of skin, NOS
17.4
57.7
48
29
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
5.0
56.2
134
304
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
7.2
53.8
83
124
ZXC50
NOMESCO Finland
Cryotherapy
7.5
50.6
75
107
R23.8
ICD-10 Finland
Other and unspecified skin changes
2.9
50.3
322
1408
TQW99
NOMESCO Finland
Other minor procedure on skin
5.4
49.7
105
214
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
9.2
47.4
59
68
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
8.5
47.0
62
77
2166A
ICD-9 Finland
Benign neoplasm of skin, Skin of upper limb, including shoulder[YLÄRAAJAN IHON BEN KASV,NAEVUS PIGMENTOSUS]
+∞
43.0
41
*
D03.6
ICD-10 Finland
Melanoma in situ of upper limb, including shoulder
109.7
39.0
42
*
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
12.0
36.2
37
32
127
Kela drug reimbursment
Transplant complication
9.3
34.4
42
47
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
7.0
31.7
49
73
QXE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in uspecified region
12.8
31.6
31
25
8720/3-C44.5
ICD-O-3
Malignant melanoma, NOS, of skin of trunk
12.8
31.6
31
25
L82
ICD-10 Finland
Seborrhoeic keratosis
2.5
31.4
240
1114
D23.6
ICD-10 Finland
Benign neoplasm: Skin of upper limb, including shoulder
11.4
31.2
33
30
PJA12
NOMESCO Finland
Sentinel node biopsy
3.3
30.4
126
420
L81.4
ICD-10 Finland
Other melanin hyperpigmentation
11.8
30.2
31
27
QBE99
NOMESCO Finland
Other excision or repair of lesion of skin of trunk
7.3
29.5
44
63
C43.50
ICD-10 Finland
Malignant melanoma of the torso without histology
27.0
28.6
39
15
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
3.6
27.5
99
301
QCE99
NOMESCO Finland
Other excision or repair of lesion of skin of upper limb
33.0
27.0
35
11
L04AA06
ATC
mycophenolic acid; systemic
6.9
25.7
40
60
S82
ICPC
Naevus/mole
2.5
25.6
198
916
C44.71
ICD-10 Finland
Basocellular carcinoma of the skin of the lower extremity including the hip
10.7
25.4
28
27
C43.59
ICD-10 Finland
Malignant melanoma of the trunk other or unspecified histology
25.9
25.4
35
14
XQ846
NOMESCO Finland
Digital dermatoscopy and registration of nevi
40.0
25.0
31
8
9733
FHL
Excision of skin change in operating room or anesthesia
7.0
24.8
38
56
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
6.7
24.4
39
60
Z94.0
ICD-10 Finland
Kidney transplant status
9.9
24.2
28
29
ZZR00
NOMESCO Finland
Flap of skin
6.5
24.1
40
64
C43.69
ICD-10 Finland
Malignant melanoma of the upper extremity including shoulder other or unspecified histology
89.1
23.8
26
*
C43.60
ICD-10 Finland
Malignant melanoma of the upper extremity including the shoulder without histology
53.4
22.2
26
5
D22.3
ICD-10 Finland
Melanocytic naevi of other and unspecified parts of face
5.0
21.0
46
96
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
17.4
20.6
32
19
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
17.4
20.6
32
19
Z2221
NOMESCO Finland
Medical doctor
1.9
18.7
300
1821
S18
ICPC
Laceration/cut
1.8
18.2
487
3468
8720/3-C44.6
ICD-O-3
Malignant melanoma, NOS, of skin of upper limb and shoulder
29.4
17.5
23
8
ZXC15
NOMESCO Finland
Use of photodynamic technique
6.5
17.2
28
44
D06BB10
ATC
imiquimod; topical
3.0
17.0
77
269
C43.72
ICD-10 Finland
Malignant melanoma of the lower extremity including the hip: 'superficial spreading' type
19.7
16.9
25
13
D04.7
ICD-10 Finland
Carcinoma in situ: Skin of lower limb, including hip
19.7
16.9
25
13
ZQZ00
NOMESCO Finland
Treatment of several skin areas
22.3
16.9
24
11
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
4.5
16.7
41
94
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
6.1
16.6
29
49
8720/2-C44.9
ICD-O-3
Melanoma in situ of skin, NOS
20.5
16.5
24
12
TQW80
NOMESCO Finland
Local dermatologic skincare
4.5
15.8
39
90
D03.5
ICD-10 Finland
Melanoma in situ of trunk
17.6
15.7
24
14
8743/3-C44.9
ICD-O-3
Low cumulative sun damage melanoma of skin, NOS
18.1
15.2
23
13
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
20.4
15.1
22
11
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
5.1
14.9
31
62
Z49.1
ICD-10 Finland
Extracorporeal dialysis
6.7
14.5
23
35
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.8
14.3
32
68
TK800
NOMESCO Finland
Hemodialysis
5.0
13.9
30
62
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
13.8
359
2479
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
6.3
13.8
23
37
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.7
13.4
75
294
L04AA01
ATC
[U] ciclosporin
6.4
13.3
22
35
D23.7
ICD-10 Finland
Benign neoplasm: Skin of lower limb, including hip
6.0
13.1
23
39
L04AD01
ATC
ciclosporin; systemic
4.8
12.9
29
62
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
4.4
12.5
31
72
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
10.7
12.3
23
22
R22.2
ICD-10 Finland
Localized swelling, mass and lump, trunk
3.1
12.1
52
176
C43
ICD-10 Finland
Malignant melanoma of skin
21.6
12.0
17
8
D22
ICD-10 Finland
Melanocytic naevi
2.6
12.0
72
292
C43.6
ICD-10 Finland
Malignant neoplasm: Malignant melanoma of upper limb, including shoulder
47.3
11.9
14
*
180
Kela drug reimbursment
Interferon alfa
19.2
11.6
17
9
A12AA04
ATC
calcium carbonate; oral
5.3
11.6
23
44
C43.61
ICD-10 Finland
Malignant melanoma of the upper extremity including the shoulder originating in lentigo maligna
121.4
11.4
12
*
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
12.9
11.2
19
15
S77
ICPC
Malignant neoplasm of skin
8.2
11.1
24
30
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
11.3
11.1
20
18
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
4.6
10.8
25
55
S21
ICPC
Skin texture symptom/complaint
1.9
10.6
159
926
A11CC03
ATC
alfacalcidol; systemic
3.8
10.4
31
83
C44.21
ICD-10 Finland
Basocellular carcinoma of the skin of the outer ear and the outer ear canal
5.4
9.7
19
36
J01DB01
ATC
cefalexin; oral
1.7
9.5
784
6934
D23.5
ICD-10 Finland
Benign neoplasm: Skin of trunk
3.2
9.4
36
114
E0000UV, ,
ATC
1.5
9.3
404
3085
L04AD02
ATC
tacrolimus; systemic
7.4
9.2
21
29
R4110
NOMESCO Finland
Physiotherapy
1.6
9.2
254
1747
C43.5
ICD-10 Finland
Malignant neoplasm: Malignant melanoma of trunk
11.6
9.1
16
14
QBE15
NOMESCO Finland
Excision of other superficial lesion of skin of trunk
11.6
9.1
16
14
ZXC20
NOMESCO Finland
Use of chemical agents
3.9
9.0
26
68
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
7.5
9.0
20
27
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.5
8.9
57
239
SPAT1153
SPAT
Removal of sutures
1.6
8.8
277
1962
B07.9
ICD-10 Finland
Verruca simplex
2.7
8.8
46
174
C44.50
ICD-10 Finland
Malignant tumor of the skin on the torso without histology
14.2
8.7
14
10
C43.71
ICD-10 Finland
Malignant melanoma of the lower extremity including the hip originating in lentigo maligna
50.5
8.7
10
*
C43.51
ICD-10 Finland
Malignant melanoma of the trunk originating in lentigo maligna
27.8
8.5
11
*
D03.7
ICD-10 Finland
Melanoma in situ of lower limb, including hip
20.2
8.5
12
6
D04.4
ICD-10 Finland
Carcinoma in situ: Skin of scalp and neck
8.0
8.4
18
23
D22.4
ICD-10 Finland
Melanocytic naevi of scalp and neck
3.8
8.4
25
67
L91.0
ICD-10 Finland
Hypertrophic scar
4.0
8.4
23
58
4056, ,
NOMESCO Finland
+∞
8.3
8
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.4
8.3
58
253
QDE99
NOMESCO Finland
Other excision or repair of lesion of skin of lower limb
9.6
8.3
16
17
C43.63
ICD-10 Finland
Malignant melanoma of upper extremity including shoulder nodular
22.2
8.0
11
5
C43.70
ICD-10 Finland
Malignant melanoma of the lower extremity including the hip without histology
13.2
7.9
13
10
C43.53
ICD-10 Finland
Malignant melanoma of the torso nodular
13.2
7.9
13
10
Z3231
NOMESCO Finland
Registered nurse
1.6
7.8
246
1739
C43.99
ICD-10 Finland
Unspecified localization of malignant melanoma of the skin other or unspecified histology
15.2
7.7
12
8
QCA99
NOMESCO Finland
Other local destruction of skin of upper limb
45.4
7.7
9
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.4
7.7
51
218
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
7.6
311
2319
QBE00
NOMESCO Finland
Excision of loose skin or fold of skin from trunk
8.1
7.6
16
20
L03AB05
ATC
interferon alfa-2b; parenteral
18.5
7.6
11
6
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
2.9
7.6
35
124
ZXA00
NOMESCO Finland
Right side
1.6
7.5
222
1544
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.4
7.5
48
202
XKD03
NOMESCO Finland
Urethral pressure profilometry
3.5
7.4
25
73
C44.60
ICD-10 Finland
Malignant tumor of the skin of the upper extremity including the shoulder without histology
+∞
7.3
7
*
8743/3-C44.5
ICD-O-3
Low cumulative sun damage melanoma of skin of trunk
+∞
7.3
7
*
TQW40, ,
SPAT
1.9
7.3
100
565
L04AX01
ATC
azathioprine; systemic
2.4
7.0
45
189
XW000
NOMESCO Finland
Bone marrow biopsy
2.6
7.0
40
159
QCA10
NOMESCO Finland
Incision of skin of upper limb
13.9
6.9
11
8
S29
ICPC
Skin symptom/complaint other
1.6
6.9
190
1299
C44.91
ICD-10 Finland
Unspecified localization of basocellular carcinoma of the skin
11.0
6.8
12
11
DHB00
NOMESCO Finland
Excision of lesion of external nose
5.7
6.8
18
32
S54
ICPC
Skin, Repair/fix-suture/cast/prosth device
2.6
6.8
37
144
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
6.7
202
1407
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
12.3
6.6
11
9
C43.49
ICD-10 Finland
Malignant melanoma of the scalp and neck other or unspecified histology
70.3
6.4
7
*
L01BC02
ATC
fluorouracil; systemic, topical
7.5
6.4
14
19
ZXA10
NOMESCO Finland
Bilateral
1.6
6.4
156
1033
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.3
6.4
46
204
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
3.8
6.4
19
51
R22.4
ICD-10 Finland
Localized swelling, mass and lump, lower limb
2.9
6.4
28
97
QAE99, ,
SPAT
5.6
6.3
17
31
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.7
6.3
122
762
8720/3-C44.7
ICD-O-3
Malignant melanoma, NOS, of skin of lower limb and hip
9.3
6.3
12
13
C43.39
ICD-10 Finland
Malignant melanoma of another or unspecified part of the face other or unspecified histology
18.1
6.3
9
5
C44
ICD-10 Finland
Other malignant neoplasms of skin
18.1
6.3
9
5
8742/3-C44.9
ICD-O-3
Lentigo maligna melanoma of skin, NOS
+∞
6.3
6
*
N18.0
ICD-10 Finland
End-stage renal disease
5.8
6.2
16
28
QB9S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in torso, unspecified
10.1
6.0
11
11
C44.52
ICD-10 Finland
Spinocellular carcinoma of the skin on the torso
10.1
6.0
11
11
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
6.1
6.0
15
25

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
308
1125
3.56
68.01
2.2
1.3
—
—
—
0
0
602
3411
3.06
60.59
3.8
2.1
—
—
—
0
0
117
359
3.57
32.18
1.4
1.2
—
—
—
0
0
166
692
2.69
26.66
1.6
1.4
—
—
—
0
0
28
32
8.98
22.50
35.9
32.3
99.48
112.08
ug/l
0.45
23
25
30
61
5.04
14.12
2.0
1.4
14.30
6.75
ug/l
0.55
30
52
380
2732
1.65
12.15
4.1
3.2
191.22
83.16
e6/l
0.36
293
2059
809
7099
1.90
11.67
24.8
18.5
13.56
13.54
%
0.18
802
7026
121
626
2.07
11.42
5.8
3.9
101.32
80.67
ng/l
1.45
108
559
475
3645
1.60
11.42
7.0
4.9
36.21
36.03
g/l
0.30
447
3452
333
2345
1.64
11.38
3.9
3.1
0.24
0.40
e6/l
1.48
244
1689
607
4950
1.62
11.23
13.1
9.4
3.79
4.08
e9/l
2.98
535
4325
344
2461
1.62
10.94
6.1
4.1
7.40
7.40
ph
0.23
247
1760
425
3212
1.58
10.66
4.8
3.8
107.53
86.57
e6/l
0.15
307
2210
551
4422
1.58
10.63
9.3
6.2
0.55
0.57
e9/l
1.40
479
3822
562
4532
1.58
10.61
9.4
6.3
1.91
1.95
e9/l
0.31
498
4029
544
4371
1.57
10.30
8.0
6.3
11.28
11.06
umol/l
0.19
524
4178
548
4433
1.55
9.89
9.4
6.3
0.04
0.04
e9/l
0.16
478
3834
563
4584
1.55
9.85
9.5
6.5
0.18
0.19
e9/l
0.32
495
4034
219
1431
1.69
9.77
3.2
2.8
0.99
1.05
e6/l
0.07
118
724
381
2858
1.55
9.58
8.5
6.2
—
—
—
0
0
725
6310
1.61
9.02
11.0
8.0
78.31
78.27
u/l
0.01
701
6005
266
1881
1.57
8.48
3.4
2.6
3.81
6.79
e6/l
4.27
243
1701
155
966
1.72
8.13
3.2
2.8
8.06
7.81
umol/l
0.06
143
844
511
4187
1.47
7.89
9.4
6.3
28.52
28.20
%
0.25
493
3987
562
4703
1.47
7.72
4.2
3.8
0.00
0.33
estimate
0.52
121
947
120
706
1.80
7.67
10.6
8.6
—
—
—
0
0
477
3872
1.46
7.64
2.8
2.5
77.90
76.26
nmol/l
0.62
456
3512
286
2097
1.52
7.62
3.3
2.7
341.73
335.28
umol/l
0.47
262
1869
198
1338
1.60
7.56
3.3
2.9
2.62
2.98
e6/l
0.17
96
635
15
17
8.94
7.56
1.0
1.9
1.10
2.05
ug/l
—
7
8
166
1074
1.66
7.54
11.3
5.9
1.08
1.04
mmol/l
1.07
161
993
497
4079
1.45
7.43
9.3
6.4
8.69
8.68
%
0.02
477
3841
556
4664
1.46
7.39
4.2
3.8
13.06
3.11
estimate
0.34
126
1007
98
549
1.87
7.32
3.1
3.1
219.34
204.32
ng/l
0.13
90
500
495
4074
1.45
7.21
9.3
6.3
2.75
2.82
%
0.28
474
3829
550
4626
1.44
7.07
4.2
3.8
0.00
0.00
estimate
0.50
122
995
494
4074
1.44
7.06
9.3
6.4
0.68
0.68
%
0.12
474
3825
649
5638
1.47
6.98
4.3
3.9
—
7215.79
—
0
14
337
2596
1.46
6.90
8.2
6.1
—
—
—
0
0
472
3875
1.43
6.83
14.1
11.2
0.00
0.00
e9/l
0.27
381
3183
159
1055
1.61
6.49
1.5
1.5
—
—
—
0
0
492
4097
1.41
6.43
11.4
7.1
1.21
1.21
mmol/l
0.05
435
3556
365
2888
1.43
6.35
4.4
3.4
2.35
2.36
mmol/l
0.53
338
2642
911
8635
2.14
6.19
14.9
11.5
25.37
25.50
u/l
0.09
895
8427
490
4096
1.40
6.16
3.5
2.7
—
—
estimate
—
0
0
644
5657
1.42
5.99
5.2
4.6
875.80
1673.35
e6/l
—
10
86
492
4136
1.39
5.87
9.4
6.2
56.64
57.09
%
0.36
481
3957
443
3673
1.38
5.68
10.1
6.5
1.21
1.21
mmol/l
0.60
419
3404
35
147
2.43
5.52
3.2
3.6
4.46
4.32
e9/l
0.12
35
147
65
352
1.91
5.42
1.8
2.0
1.41
1.50
g/l
0.37
58
317
879
8289
1.74
5.28
19.5
14.9
22.28
23.17
mg/l
0.34
725
6809
87
525
1.72
5.11
9.8
9.7
1.18
1.31
%
1.02
87
519
444
3726
1.36
5.10
3.7
3.4
6.30
6.23
ph
0.66
246
2096
12
19
6.38
5.09
6.9
3.2
—
—
—
0
0
41
193
2.17
5.01
3.4
3.4
60.71
57.89
%
0.72
41
193
188
1368
1.47
4.96
5.6
3.5
0.82
0.82
mmol/l
0.23
176
1305
316
2525
1.38
4.91
3.2
2.9
0.00
0.04
—
6
45
196
1442
1.45
4.88
3.6
2.5
13.17
13.29
umol/l
0.09
190
1344
360
2950
1.35
4.73
4.0
3.1
28.35
31.76
u/l
1.66
345
2802
130
886
1.54
4.70
8.3
8.5
0.43
0.93
mmol/l
0.64
106
729
737
6737
1.41
4.69
4.8
4.5
14.64
14.64
pmol/l
0.00
694
6232
120
806
1.56
4.63
2.3
2.4
33.89
36.39
u/l
0.29
104
672
131
899
1.53
4.59
8.5
8.4
7.42
7.41
ph
0.14
68
502
109
720
1.58
4.52
3.7
2.7
10.17
10.66
g/l
0.56
100
667
834
7820
1.52
4.47
5.9
5.5
1.86
1.88
mu/l
0.17
796
7318
82
506
1.68
4.46
10.3
10.0
0.65
0.66
%
0.11
82
501
215
1635
1.41
4.43
3.3
2.9
2.44
2.44
mmol/l
0.02
194
1478
94
602
1.62
4.43
2.3
2.4
32.97
18.83
au/ml
—
10
64
103
676
1.59
4.39
2.4
2.5
0.37
0.50
e6/l
0.27
97
646
119
808
1.54
4.37
6.0
3.9
1.20
1.81
mmol/l
1.06
106
683
179
1334
1.42
4.12
3.7
2.5
2.30
2.34
g/l
0.46
174
1237
343
2835
1.33
4.12
3.2
2.3
—
—
—
0
0
144
1031
1.47
4.11
2.0
1.6
—
—
—
0
0
80
502
1.65
4.10
7.2
4.0
23.96
24.18
mmol/l
0.23
80
496
49
267
1.88
4.07
9.0
5.0
1.83
1.43
mg/l
1.44
49
239
252
1993
1.36
4.06
2.0
1.7
2.11
1.20
mg/l
0.61
193
1538
162
1190
1.43
4.04
2.1
1.6
—
—
—
0
0
203
1554
1.39
4.00
4.4
3.8
369.12
458.36
ng/l
0.22
157
1127
304
2479
1.33
3.99
2.4
2.1
225.58
231.15
u/l
0.04
287
2356
120
835
1.50
3.94
5.9
3.8
5.78
5.79
kpa
0.03
120
807
212
1639
1.38
3.93
3.7
2.8
532.83
535.53
mosm/kgh2o
0.06
189
1438
170
1267
1.42
3.91
2.6
2.0
29.22
29.49
s
0.32
165
1232
831
7838
1.46
3.79
5.3
4.8
5.82
5.85
mmol/l
0.24
795
7269
120
842
1.49
3.79
6.2
3.9
7.37
7.38
ph
0.48
70
490
403
3441
1.30
3.73
1.9
1.9
1.31
1.34
mmol/l
0.24
353
2946
37
189
2.00
3.72
1.9
1.7
—
—
—
0
0
40
213
1.92
3.59
1.9
1.7
33.60
646.90
e6/l
0.60
30
164
262
2122
1.32
3.54
3.1
2.3
—
—
—
0
0
902
8679
1.68
3.52
25.5
18.9
78.24
74.63
umol/l
1.99
894
8590
318
2648
1.30
3.51
3.3
3.0
—
—
—
0
0
47
266
1.81
3.50
1.9
2.4
10.09
10.64
g/l
0.36
47
246
503
4448
1.28
3.43
3.5
3.2
123.04
106.28
ug/l
0.45
480
4189
39
210
1.89
3.40
1.9
1.6
6.48
12.46
e6/l
0.49
29
157
106
743
1.48
3.37
8.4
7.8
1.15
1.31
mmol/l
1.39
106
729
928
9017
1.96
3.29
30.6
22.7
90.71
90.74
fl
0.06
928
8942
928
9017
1.96
3.29
30.7
22.8
250.28
253.53
e9/l
0.83
923
8875
33
170
1.97
3.27
2.2
1.4
176.89
147.76
au/ml
—
9
48
928
9020
1.95
3.24
30.6
22.7
30.22
30.22
pg
0.04
928
8943
928
9020
1.95
3.24
31.3
23.2
40.12
40.25
%
0.40
928
8942
928
9020
1.95
3.24
30.7
22.8
4.47
4.49
e12/l
0.34
921
8854
847
8063
1.44
3.22
5.2
4.8
4.64
4.64
mmol/l
0.07
811
7594
18
72
2.53
3.22
2.3
2.9
37.09
42.01
%
0.55
18
72
928
9023
1.94
3.18
30.7
22.9
6.62
6.75
e9/l
1.04
918
8850
224
1799
1.32
3.18
1.9
1.7
—
—
—
0
0
48
282
1.74
3.18
2.5
2.7
—
—
—
0
0
269
2216
1.30
3.17
5.0
4.2
—
—
—
0
0
928
9024
1.94
3.17
30.9
23.0
133.94
134.69
g/l
0.92
928
8947
865
8274
1.47
3.13
23.2
17.1
139.73
139.63
mmol/l
0.66
853
8123
253
2071
1.30
3.12
6.3
4.7
—
—
—
0
0
9
20
4.53
3.12
2.2
1.6
—
—
—
0
0
40
224
1.82
3.11
5.0
8.0
1.36
1.31
mmol/l
0.09
32
198
79
530
1.53
3.11
2.5
2.4
—
—
—
0
0
35
188
1.89
3.09
2.1
1.4
—
—
—
0
0
866
8292
1.47
3.05
23.5
17.2
3.94
3.96
mmol/l
0.55
855
8122
9
21
4.32
3.00
1.2
1.2
—
—
—
0
0
843
8038
1.41
2.98
5.0
4.7
1.48
1.47
mmol/l
0.24
799
7531
96
678
1.46
2.96
4.4
3.0
68.62
69.86
e9/l
0.12
66
503
38
213
1.82
2.96
1.2
1.2
58.10
41.50
u/ml
—
6
24
161
1245
1.35
2.95
2.5
2.6
121.13
110.13
ug/g
0.18
133
985
8
17
4.74
2.92
1.3
1.5
—
—
—
0
0
21
95
2.24
2.91
1.3
1.8
—
—
—
0
0
155
1195
1.35
2.89
3.6
3.2
0.67
0.76
ug/l
1.01
112
772
26
129
2.04
2.88
2.1
1.7
—
—
—
0
0
163
1272
1.34
2.81
1.4
1.4
277.04
495.16
titre
1.94
27
277
853
8169
1.41
2.76
5.8
5.4
2.69
2.73
mmol/l
0.59
812
7668
18
78
2.33
2.76
1.3
1.1
—
—
—
0
0
308
2628
1.25
2.67
3.3
2.5
67.12
90.45
u/l
0.33
290
2454
21
99
2.15
2.66
2.5
2.1
—
—
—
0
0
11
35
3.17
2.65
1.4
1.4
122.82
173.45
mmol/24h
1.26
11
35
15
61
2.48
2.63
1.3
1.2
0.69
0.53
ratio
—
7
33
47
291
1.65
2.62
1.3
1.2
—
—
—
0
0
38
222
1.74
2.61
4.6
3.6
5.74
2.47
ratio
0.38
18
127
17
74
2.32
2.59
1.1
1.1
—
—
—
0
0
411
3638
1.23
2.51
2.2
2.1
98.06
95.58
pmol/l
0.51
217
1962
540
4916
1.23
2.50
6.2
5.0
6.47
6.59
mmol/l
0.74
516
4602
246
2059
1.26
2.49
3.8
3.9
1.02
1.76
kg/l
0.50
162
1360
41
249
1.68
2.47
4.8
3.7
63.52
71.45
mg/l
0.11
34
214
41
249
1.68
2.47
4.7
3.7
35.06
50.46
mg/l
0.49
34
215
19
89
2.16
2.46
1.3
1.3
—
—
—
0
0
69
475
1.49
2.45
10.3
10.0
24.19
24.39
mmol/l
0.18
69
467
106
793
1.38
2.41
1.8
1.5
—
—
—
0
0
7
17
4.14
2.36
1.3
1.0
—
—
—
0
0
885
8567
1.44
2.32
16.6
13.3
—
—
—
0
0
30
170
1.79
2.31
1.4
1.9
—
—
—
0
0
57
383
1.52
2.29
1.4
1.4
262.74
244.08
miu/ml
0.13
30
186
12
47
2.57
2.27
1.3
1.6
0.39
0.50
e9/l
1.08
12
47
85
620
1.41
2.25
2.5
2.3
13.58
11.79
nmol/l
0.88
78
560
399
3551
1.21
2.24
4.0
3.7
0.05
0.03
estimate
0.28
96
828
799
7634
1.28
2.17
4.4
4.1
1.26
1.25
mmol/l
0.22
752
7104
80
582
1.41
2.16
3.0
3.5
4.37
4.57
pmol/l
1.03
74
519
32
190
1.71
2.12
1.3
1.4
4.37
2.97
ug/l
0.79
27
171
21
109
1.95
2.11
1.4
1.3
—
—
—
0
0
407
3646
1.20
2.10
15.7
12.9
1.23
1.21
inr
0.42
331
3025
125
981
1.32
2.09
1.3
1.3
—
—
—
0
0
103
787
1.35
2.07
2.9
4.4
21.35
24.23
ug/l
0.06
75
649
7
20
3.52
2.06
1.1
1.2
—
—
—
0
0
87
650
1.37
2.02
1.4
1.3
154.06
220.86
u/ml
0.47
79
603
21
111
1.91
2.02
1.3
1.3
—
73.85
—
0
8
267
2305
1.22
2.00
3.6
3.2
1416.22
1187.13
ng/l
0.38
226
1968
35
217
1.64
1.99
6.1
3.0
1.56
2.10
index
0.35
18
114
7
21
3.35
1.96
1.0
1.0
—
—
—
0
0
793
7593
1.26
1.95
6.4
6.0
38.06
38.70
mmol/mol
1.49
759
7158
259
2237
1.22
1.93
1.4
1.3
0.78
1.66
u/ml
1.70
76
619
78
579
1.38
1.89
2.4
1.8
1.62
1.31
g/l
0.35
73
541
13
60
2.18
1.78
1.2
1.7
13.98
12.33
umol/l
0.30
13
55
6
18
3.35
1.75
2.0
1.1
—
—
—
0
0
9
36
2.51
1.74
1.2
2.3
89.14
69.71
ug/l
—
9
36
236
2040
1.21
1.73
6.7
5.6
2.07
3.04
ug/l
1.15
216
1834
236
2705
0.83
1.71
3.0
3.5
—
0.73
—
0
11
228
1972
1.21
1.66
1.7
1.5
2.06
2.36
g/l
2.39
146
1242
148
1226
1.25
1.64
2.2
2.0
—
—
—
0
0
286
2529
1.19
1.63
4.1
3.5
56.22
47.34
mg/l
0.21
178
1655
112
900
1.28
1.60
4.7
2.9
1.82
1.81
%
0.03
105
811
10
43
2.34
1.59
2.6
1.7
1.73
1.96
umol/l
—
10
38
65
859
0.74
1.57
1.4
1.3
—
—
—
0
0
95
753
1.29
1.52
1.2
1.2
—
—
—
0
0
7
28
2.51
1.45
1.6
2.3
0.63
0.61
mmol/l
—
7
28
96
769
1.28
1.43
6.6
4.7
1.23
0.98
%
0.34
32
237
36
246
1.48
1.42
1.1
1.2
—
—
—
0
0
25
157
1.61
1.41
1.8
1.5
—
—
—
0
0
272
2423
1.17
1.40
1.7
1.7
20.13
20.21
nmol/l
0.03
250
2049
10
46
2.19
1.40
1.1
3.3
1372.40
735.98
u/ml
—
10
46
7
29
2.42
1.39
1.4
1.5
15.46
13.85
pmol/l
—
7
24
91
727
1.28
1.39
6.7
4.7
0.83
0.62
%
0.37
30
214
5
17
2.95
1.36
1.4
1.0
—
—
—
0
0
5
17
2.95
1.36
1.4
1.0
—
—
—
0
0
5
17
2.95
1.36
1.4
1.0
—
—
—
0
0
31
452
0.68
1.35
1.3
1.7
—
—
—
0
0
34
233
1.48
1.33
1.5
1.3
—
—
—
0
0
35
242
1.46
1.31
1.6
1.8
35.51
42.21
nmol/l
1.51
35
228
45
327
1.39
1.30
1.5
1.5
9.40
10.16
u/l
0.16
34
262
288
2597
1.16
1.26
4.6
3.9
0.00
0.01
estimate
1.34
113
947
29
421
0.68
1.25
1.3
1.9
—
—
—
0
0
11
202
0.54
1.23
1.7
2.3
—
—
—
0
0
38
271
1.42
1.23
1.5
2.0
2.70
4.24
iu/l
1.20
14
112
31
213
1.47
1.22
5.6
3.8
3.83
3.88
mmol/l
0.33
31
208
195
1712
1.17
1.20
1.4
1.3
21.61
29.64
iu/ml
0.97
54
511
73
579
1.28
1.20
1.5
1.4
22.47
24.68
iu/l
0.27
62
490
239
2133
1.16
1.20
2.1
2.1
—
—
—
0
0
5
112
0.44
1.13
1.4
2.9
—
—
—
0
0
7
30
2.34
1.12
1.6
2.3
30.43
28.63
%
—
7
30
15
88
1.72
1.11
1.4
1.3
6.25
6.42
mmol/l
0.07
15
82
56
715
0.77
1.11
11.2
3.8
7.33
7.35
ph
0.27
45
515
77
622
1.26
1.11
2.8
2.4
10.30
6.20
ug/l
0.33
71
558
309
3368
0.88
1.11
2.7
3.0
—
—
—
0
0
289
2629
1.14
1.10
3.5
3.2
0.01
0.04
estimate
0.48
90
809
42
312
1.36
1.10
3.6
3.7
81.98
1469.59
u/ml
1.58
31
272
18
112
1.62
1.09
1.4
1.4
—
—
—
0
0
18
112
1.62
1.09
1.4
1.4
—
—
—
0
0
18
112
1.62
1.09
1.4
1.4
—
—
—
0
0
18
112
1.62
1.09
1.4
1.4
—
—
—
0
0
5
21
2.39
1.09
1.2
1.4
2.97
3.71
mmol/l
—
5
16
89
733
1.24
1.09
7.0
4.8
0.20
0.11
%
0.40
25
200
8
41
1.96
1.09
1.5
1.2
—
84.60
%
—
0
5
33
454
0.72
1.09
1.3
1.8
—
—
—
0
0
33
451
0.72
1.05
1.3
1.8
—
—
—
0
0
33
451
0.72
1.05
1.3
1.8
—
—
—
0
0
12
67
1.80
1.05
1.0
1.0
—
—
—
0
0
15
91
1.66
1.01
2.1
1.8
22.95
24.29
ng/l
0.10
15
91
7
35
2.01
1.00
1.1
1.5
—
—
—
0
0
28
198
1.43
0.98
1.6
1.5
0.32
0.40
nmol/l
0.40
23
163
50
389
1.30
0.98
2.2
1.9
—
—
—
0
0
5
23
2.18
0.98
2.2
1.5
—
—
—
0
0
0
29
0.00
0.98
0.0
2.4
—
—
—
0
0
30
410
0.72
0.97
1.7
1.6
0.25
0.33
mg/l
0.65
12
185
32
233
1.39
0.96
1.4
1.3
—
—
—
0
0
14
85
1.66
0.94
1.1
1.1
—
—
—
0
0
282
2587
1.13
0.94
4.6
4.2
12.63
8.60
mg/mmol
0.50
175
1636
25
349
0.71
0.92
1.1
1.1
1.54
1.54
g/l
0.05
25
349
306
2826
1.12
0.91
4.0
3.4
6.91
7.73
mmol/l
3.09
270
2422
89
750
1.21
0.90
7.8
5.2
0.08
0.19
%
0.67
25
188
71
585
1.23
0.89
1.2
1.2
—
—
—
0
0
17
253
0.67
0.88
9.4
8.6
—
—
—
0
0
149
1315
1.16
0.88
1.8
1.8
—
—
—
0
0
20
137
1.47
0.84
1.6
1.3
63.17
63.90
mmol/l
0.02
12
115
60
490
1.24
0.83
1.2
1.1
—
0.90
—
0
5
13
81
1.61
0.81
1.1
1.1
—
—
—
0
0
22
156
1.42
0.79
3.5
3.6
0.76
2.39
mmol/l
4.68
13
100
34
260
1.32
0.79
5.7
3.9
1.30
1.38
mmol/l
0.20
34
254
8
48
1.67
0.79
14.1
2.7
0.63
0.79
index
—
8
48
24
325
0.73
0.77
1.6
2.5
—
—
—
0
0
87
1011
0.85
0.76
1.7
1.9
3.43
3.43
ratio
0.00
59
784
6
34
1.77
0.76
1.7
1.3
—
—
—
0
0
59
487
1.23
0.76
1.2
1.2
—
—
—
0
0
22
158
1.40
0.75
1.1
1.1
—
—
—
0
0
13
84
1.56
0.72
1.5
1.4
—
—
—
0
0
5
26
1.93
0.70
1.4
1.2
—
—
—
0
0
29
222
1.32
0.68
1.1
1.1
1.02
2.41
u/ml
1.05
15
110
48
393
1.23
0.68
2.4
2.3
—
—
—
0
0
28
362
0.77
0.67
1.2
1.1
0.84
0.90
g/l
0.63
28
362
599
5788
1.09
0.67
3.5
3.2
47.58
43.98
u/l
0.41
567
5493
250
2326
1.10
0.64
2.6
2.3
2.56
2.81
mg/l
1.20
225
2001
28
358
0.78
0.63
1.3
1.9
—
—
—
0
0
94
826
1.15
0.63
2.8
2.0
0.07
0.03
estimate
0.27
27
189
23
173
1.34
0.62
3.2
3.7
—
—
—
0
0
5
30
1.67
0.61
2.4
4.7
—
28.19
—
0
7
5
30
1.67
0.61
2.0
3.6
—
—
—
0
0
26
200
1.31
0.61
1.7
1.3
268.69
243.23
u/ml
0.12
16
118
13
88
1.48
0.60
1.1
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
0.69
—
0
11
0
22
0.00
0.59
0.0
1.2
—
138.00
—
0
17
20
149
1.35
0.58
1.1
1.1
1.32
7.45
u/ml
2.04
13
58
25
193
1.30
0.58
1.1
1.1
9.39
3.69
u/ml
0.80
14
99
61
522
1.18
0.57
2.2
2.3
3956.52
6467.76
u/l
0.59
25
219
73
635
1.16
0.57
6.2
4.0
1.22
1.23
mmol/l
0.41
60
543
67
772
0.86
0.57
1.5
1.7
3.51
3.46
mmol/l
0.08
38
550
19
144
1.33
0.51
1.6
1.6
—
—
—
0
0
9
65
1.39
0.50
1.9
2.4
1.22
1.95
u/field
—
9
38
171
1583
1.10
0.50
1.3
1.3
10.67
9.83
u/ml
0.07
63
612
119
1305
0.90
0.49
1.6
1.7
1249.44
1188.44
nmol/l
0.31
95
986
7
47
1.49
0.47
3.3
2.0
186.14
103.88
ng/l
—
7
47
19
146
1.31
0.47
1.2
1.2
—
—
—
0
0
115
1049
1.11
0.46
1.9
1.8
—
—
—
0
0
7
49
1.43
0.46
1.0
1.1
633.57
1746.53
miu/ml
—
7
49
17
129
1.32
0.46
1.2
1.2
—
—
—
0
0
5
84
0.59
0.45
2.2
2.1
—
—
—
0
0
22
174
1.27
0.45
4.5
2.5
77.65
110.94
ug/min
0.32
13
108
44
377
1.18
0.44
1.1
1.1
—
—
—
0
0
128
1180
1.10
0.42
1.3
1.2
—
—
—
0
0
30
249
1.21
0.42
1.7
1.4
286.00
296.60
ug/g
0.12
22
143
5
33
1.52
0.41
1.6
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
0.02
—
0
15
55
483
1.15
0.41
1.2
1.1
—
161.10
—
0
10
41
352
1.17
0.41
1.5
1.3
—
—
—
0
0
0
17
0.00
0.40
0.0
1.9
—
—
—
0
0
0
18
0.00
0.40
0.0
3.2
—
7.11
—
0
18
5
35
1.43
0.39
3.8
1.8
0.00
0.00
estimate
—
5
35
159
1697
0.92
0.39
1.7
1.7
449.98
32120792.59
pmol/l
1.75
136
1429
5
36
1.39
0.38
1.0
1.4
79.40
78.96
mg/l
—
5
28
292
3047
0.94
0.38
3.7
3.7
28.71
67.73
ng/l
1.02
188
2047
23
188
1.23
0.37
1.1
1.1
0.77
1.39
u/ml
—
7
78
9
68
1.33
0.37
1.0
1.2
—
—
—
0
0
5
37
1.35
0.37
1.2
1.6
—
—
—
0
0
10
72
1.39
0.37
1.4
1.3
—
—
—
0
0
20
162
1.24
0.35
5.3
3.3
11.80
8.18
pmol/l
0.98
20
162
6
42
1.43
0.35
2.3
2.4
43.96
48.99
umol/l
—
6
36
23
276
0.83
0.34
1.4
1.2
—
—
—
0
0
30
257
1.17
0.32
1.2
1.1
7.25
6.69
eliau/ml
—
6
34
281
2706
1.05
0.30
1.5
1.6
—
—
—
0
0
7
56
1.25
0.29
1.0
1.0
—
1.45
—
0
17
10
76
1.32
0.28
1.8
1.1
—
—
—
0
0
43
384
1.13
0.28
1.4
1.9
5.41
8.60
iu/ml
—
9
84
36
318
1.14
0.27
1.6
1.6
—
—
—
0
0
17
141
1.21
0.26
1.5
1.4
—
—
—
0
0
11
87
1.27
0.24
5.3
3.9
30.58
68.08
u/ml
0.91
11
87
35
312
1.13
0.24
1.5
1.5
—
—
—
0
0
6
84
0.71
0.24
1.0
1.1
—
—
—
0
0
33
295
1.12
0.22
6.4
3.4
210.05
271.61
mg/l
0.45
22
132
5
42
1.19
0.21
1.2
1.4
125.60
151.22
nmol/l
—
5
42
0
11
0.00
0.21
0.0
1.3
—
1.71
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
0.14
—
0
5
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
18.37
—
0
10
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
34
306
1.12
0.21
1.5
1.5
1.28
1.28
mm
0.01
21
219
8
105
0.76
0.21
1.7
1.2
—
—
—
0
0
22
192
1.15
0.21
1.1
1.1
0.54
1.58
u/ml
1.05
15
95
0
13
0.00
0.21
0.0
2.1
—
3.62
—
0
6
0
14
0.00
0.20
0.0
4.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
9
112
0.80
0.20
4.3
2.4
31.11
32.90
pg
—
9
112
6
53
1.13
0.18
1.2
1.2
—
—
—
0
0
29
261
1.11
0.18
1.3
1.2
—
—
—
0
0
10
82
1.22
0.17
4.4
3.9
—
—
—
0
0
5
67
0.74
0.17
1.0
1.0
—
—
—
0
0
5
69
0.72
0.17
1.0
1.3
274372.00
158096.82
e6/l
—
5
49
48
447
1.08
0.16
1.1
1.1
—
—
—
0
0
6
78
0.77
0.15
1.5
2.1
—
—
—
0
0
10
83
1.21
0.15
1.2
1.1
—
—
—
0
0
10
119
0.84
0.15
2.0
3.2
—
—
—
0
0
9
81
1.11
0.15
2.1
5.5
10.60
10.77
%
—
9
81
9
81
1.11
0.15
1.7
1.4
—
—
—
0
0
46
430
1.07
0.14
2.8
2.0
0.00
0.01
estimate
0.50
21
146
77
734
1.05
0.14
5.7
3.8
—
—
—
0
0
10
84
1.19
0.14
1.5
1.6
—
—
—
0
0
19
210
0.90
0.12
1.2
1.1
—
—
—
0
0
5
44
1.14
0.10
1.0
1.1
—
—
—
0
0
18
164
1.10
0.09
1.1
1.1
7.32
3.72
u/ml
0.30
13
74
10
87
1.15
0.09
3.7
2.1
22.50
24.36
nmol/l
—
10
80
19
174
1.09
0.09
2.8
4.0
21.02
27.74
mg/l
0.58
13
121
36
340
1.06
0.09
1.6
1.6
31.04
8.08
u/ml
—
10
74
15
136
1.10
0.08
1.4
1.1
—
—
—
0
0
12
107
1.12
0.08
2.1
2.2
—
—
—
0
0
21
195
1.08
0.08
1.2
1.1
—
—
—
0
0
6
70
0.86
0.07
1.5
2.7
191.33
912.96
mg
—
6
70
6
73
0.82
0.07
1.0
1.1
279.17
291.66
mg/l
—
6
67
8
76
1.05
0.07
1.1
1.1
137.63
111.62
pmol/l
—
8
76
14
153
0.91
0.07
1.1
1.2
1.17
6.91
u/ml
—
6
65
21
196
1.07
0.07
1.2
1.1
—
—
—
0
0
8
92
0.87
0.06
1.9
2.6
1.19
1.19
mmol/l
—
8
92
114
1164
0.98
0.06
1.4
1.5
—
—
—
0
0
8
94
0.85
0.06
1.9
2.6
4.16
4.04
mmol/l
—
8
94
8
94
0.85
0.06
1.9
2.6
107.38
105.49
mmol/l
—
8
94
42
404
1.04
0.06
1.5
1.6
62.05
61.35
ug/l
0.04
31
346
13
119
1.09
0.06
1.5
1.3
0.85
15.73
nmol/l
0.48
13
112
72
702
1.03
0.05
2.7
2.3
6.07
6.10
ph
0.10
58
473
17
182
0.93
0.05
2.4
2.9
90.41
89.99
%
0.09
17
176
49
505
0.97
0.05
1.6
1.7
—
—
—
0
0
88
863
1.02
0.04
1.5
1.4
—
—
—
0
0
72
705
1.02
0.04
1.5
1.6
891.12
987.57
mu/l
0.51
56
594
72
735
0.98
0.04
1.3
1.2
58.86
150.26
u/ml
4.61
26
292
16
170
0.94
0.04
1.9
1.9
0.81
0.89
nmol/l
0.34
16
146
13
121
1.08
0.03
1.2
1.2
—
—
—
0
0
15
141
1.06
0.03
1.1
1.0
1.24
1.89
eliau/ml
—
10
64
15
141
1.06
0.03
1.1
1.2
—
—
—
0
0
37
380
0.97
0.03
1.9
1.8
—
—
—
0
0
11
103
1.07
0.02
1.6
1.3
—
—
nmol/l
—
0
0
17
163
1.04
0.01
1.1
1.1
—
—
—
0
0
39
384
1.02
0.00
5.6
3.6
—
—
—
0
0
13
126
1.03
0.00
1.0
1.1
1.51
1.48
g/l
0.10
13
117
19
194
0.98
0.00
3.8
4.5
—
—
—
0
0
10
102
0.98
0.00
1.3
1.1
—
—
—
0
0
10
97
1.03
0.00
1.9
2.2
—
—
—
0
0
55
549
1.00
0.00
4.6
3.6
7.42
7.42
ph
0.02
46
455
110
1105
0.99
0.00
3.0
3.2
5.35
5.37
e9/l
0.01
104
978
12
115
1.04
0.00
1.5
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
41.13
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
0.03
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
99.00
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.2
—
99.60
—
0
5
7
76
0.92
-0.00
1.1
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
616.44
—
0
5
7
70
1.00
-0.00
1.1
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
62
0.97
-0.00
1.2
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
387.80
—
0
5
5
51
0.98
-0.00
1.0
1.3
4.32
7.23
u/l
—
5
43
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1.01
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_MELANOCYTIC_UPPERLIMB and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_MELANOCYTIC_UPPERLIMB 0.956 [0.77, 1.18] 0.675
Birth year 0.993 [0.98, 1.0] 0.108

During the follow-up period (1.1.1998 — 31.12.2019), 141 out of 2628 females with CD2_BENIGN_MELANOCYTIC_UPPERLIMB died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_MELANOCYTIC_UPPERLIMB 1.079 [0.87, 1.33] 0.484
Birth year 0.986 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 195 out of 1808 males with CD2_BENIGN_MELANOCYTIC_UPPERLIMB died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_MELANOCYTIC_UPPERLIMB.

N-year risk Females Males
1 0.078% 0.197%
5 0.423% 1.251%
10 1.2% 3.089%
15 2.353% 6.013%
20 4.284% 10.315%

Relationships between endpoints

Index endpoint: CD2_BENIGN_MELANOCYTIC_UPPERLIMB – Melanocytic naevi of upper limb, including shoulder

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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