Other protozoal intestinal diseases

AB1_OTHER_PROTOZOAL

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A07
  • Hospital discharge: ICD-9 007.
  • Hospital discharge: ICD-8 00[7]
  • Cause of death: ICD-10 A07
  • Cause of death: ICD-9 007.
  • Cause of death: ICD-8 00[7]

2 out of 7 registries used, show all original rules.

617

4. Check minimum number of events

None

617

5. Include endpoints

None

617

6. Filter based on genotype QC (FinnGen only)

551

Control definitions (FinnGen only)

Control exclude
AB1_INTESTINAL_INFECTIONS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4130 2179 1912
Only index persons 3443 1892 1551
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.05
Only index persons 0.06 0.07 0.06
Median age at first event (years)
Whole population 32.48 34.90 29.57
Only index persons 34.41 35.94 32.55

-FinnGen-

Key figures

All Female Male
Number of individuals 551 362 189
Unadjusted period prevalence (%) 0.11 0.13 0.09
Median age at first event (years) 45.40 43.34 49.34

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
583
Matched controls
5830
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A07.8
ICD-10 Finland
Other specified protozoal intestinal diseases
4185.3
297.3
261
*
A07.1
ICD-10 Finland
Giardiasis [lambliasis]
789.7
132.0
125
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
7.2
108.3
210
421
P01AB01
ATC
metronidazole; oral, rectal
6.5
101.2
418
1640
A07.9
ICD-10 Finland
Protozoal intestinal disease, unspecified
+∞
80.1
75
*
00710
ICD-8 Finland
Other protozoal intestinal diseases, Giardiasis
+∞
54.0
51
*
A07.2
ICD-10 Finland
Cryptosporidiosis
+∞
47.6
45
*
K59.1
ICD-10 Finland
Functional diarrhoea
5.5
30.4
62
123
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.6
28.8
284
1544
D11
ICPC
Diarrhoea
3.4
28.1
121
420
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
4.5
25.6
68
168
UJF30
NOMESCO Finland
Ileoscopy through colon
3.5
23.2
91
296
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
5.4
21.0
43
85
A06AC01
ATC
ispaghula (psylla seeds); oral
2.4
18.9
175
890
A02BC05
ATC
esomeprazole; systemic
2.2
18.8
261
1571
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
103.4
18.7
20
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
18.6
181
940
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
2.2
18.1
216
1220
UJF32
NOMESCO Finland
Coloscopy
2.4
17.9
164
828
Z2221
NOMESCO Finland
Medical doctor
2.2
17.4
200
1108
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
4.7
17.3
41
92
D01
ICPC
Abdominal pain/cramps general
2.6
16.8
108
461
C10AC01
ATC
colestyramine; oral
6.3
16.5
28
46
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
7.1
15.8
24
35
Z71.8
ICD-10 Finland
Other specified counselling
2.1
15.8
246
1522
A04
ICPC
Weakness/tiredness general
2.4
14.9
116
540
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.5
14.0
101
454
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
5.6
13.6
26
48
00799
ICD-8 Finland
Other protozoal intestinal diseases, Other and unspecified
+∞
13.6
13
*
R07.4
ICD-10 Finland
Chest pain, unspecified
2.1
13.0
169
965
R53
ICD-10 Finland
Malaise and fatigue
2.0
12.4
171
996
J02AC01
ATC
fluconazole; systemic
1.9
12.0
253
1695
Z01.7
ICD-10 Finland
Laboratory examination
2.2
11.8
122
637
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.6
11.7
72
299
J01MA02
ATC
ciprofloxacin; systemic
1.9
10.9
210
1356
D96
ICPC
Worms/other parasites
28.6
10.8
14
5
A04.9
ICD-10 Finland
Bacterial intestinal infection, unspecified
61.1
10.7
12
*
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
2.6
10.7
68
287
00920
ICD-8 Finland
Diarrhoeal disease, Gastroenteritis (acuta) (infectiosa)
+∞
10.4
10
*
0093A
ICD-9 Finland
Ill-defined intestinal infections, Diarrhoea of presumed infectious origin
+∞
10.4
10
*
A06.9
ICD-10 Finland
Amoebiasis, unspecified
+∞
10.4
10
*
0071A
ICD-9 Finland
Other protozoal intestinal diseases, Giardiasis
+∞
10.4
10
*
R4110
NOMESCO Finland
Physiotherapy
1.9
10.3
167
1019
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
10.1
219
1460
ZXE00
NOMESCO Finland
One hour or less
1.8
9.8
233
1593
D18
ICPC
Change in faeces/bowel movements
4.3
9.5
24
57
A06
ICD-10 Finland
Amoebiasis
+∞
9.4
9
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
9.4
113
621
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
9.3
160
991
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.0
9.2
116
647
R51.80
ICD-10 Finland
Headache
2.0
9.2
117
656
A02BC02
ATC
pantoprazole; systemic
1.7
9.1
374
2955
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.1
9.0
98
518
K30
ICD-10 Finland
Functional dyspepsia
2.2
9.0
77
371
UJF30, ,
SPAT
12.8
8.9
15
12
UJF92
NOMESCO Finland
Capsular endoscopy
5.0
8.9
19
39
E0000UV, ,
ATC
1.7
8.7
249
1777
R19.4
ICD-10 Finland
Change in bowel habit
3.8
8.7
26
70
EB1AA, ,
SPAT
2.5
8.7
55
231
D06
ICPC
Abdominal pain localized other
2.4
8.7
63
282
Z3231
NOMESCO Finland
Registered nurse
1.8
8.7
161
1017
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
4.6
8.2
19
42
R83
ICPC
Respiratory infection other
1.7
8.0
187
1257
A02BC01
ATC
omeprazole; systemic
1.8
8.0
151
956
J01MA06
ATC
norfloxacin; oral
2.1
7.8
76
384
M79.6
ICD-10 Finland
Pain in limb
1.6
7.8
254
1860
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
4.2
7.6
20
49
A02BA02
ATC
ranitidine; systemic
1.9
7.5
98
551
U01
ICPC
Dysuria/painful urination
2.4
7.5
53
235
A06.8
ICD-10 Finland
Amoebic infection of other sites
81.1
7.4
8
*
Z3226
NOMESCO Finland
Physiotherapist
1.9
7.4
106
616
H01.0
ICD-10 Finland
Blepharitis
2.4
7.3
53
237
00000, ,
ICD-8 Finland
+∞
7.3
7
*
A07
ICD-10 Finland
Other protozoal intestinal diseases
+∞
7.3
7
*
N02AX02
ATC
tramadol; systemic, rectal
1.6
7.2
223
1604
A11
ICPC
Chest pain NOS
2.3
7.2
54
245
N01
ICPC
Headache
1.9
7.2
93
522
R42
ICD-10 Finland
Dizziness and giddiness
1.8
7.1
122
748
A97
ICPC
No disease
1.8
7.0
127
791
K03.80
ICD-10 Finland
Irradiated enamel
2.5
7.0
43
178
H04.10
ICD-10 Finland
Dry eye syndrome
2.0
7.0
74
387
L01
ICPC
Neck symptom/complaint
1.8
7.0
105
619
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
3.4
6.9
24
72
N06AX11
ATC
mirtazapine; oral
1.6
6.9
193
1354
D19
ICPC
Teeth/gum symptom/complaint
1.6
6.8
200
1419
M01AB05
ATC
diclofenac; systemic, rectal
1.6
6.8
367
3004
J01MA01
ATC
ofloxacin; systemic
2.4
6.7
47
208
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
6.4
324
2597
L08
ICPC
Shoulder symptom/complaint
1.7
6.4
131
845
D12.0
ICD-10 Finland
Benign neoplasm: Caecum
5.6
6.3
17
31
J01FA10
ATC
azithromycin; systemic
1.6
6.3
343
2787
0078A
ICD-9 Finland
Other protozoal intestinal diseases, Other specified protozoal intestinal diseases[CRYPTOSPORIDIOSIS]
+∞
6.3
6
*
A07.0
ICD-10 Finland
Balantidiasis
+∞
6.3
6
*
H93.1
ICD-10 Finland
Tinnitus
2.3
6.3
45
201
L92
ICPC
Shoulder syndrome
4.0
6.2
17
43
K29.7
ICD-10 Finland
Gastritis, unspecified
3.4
6.2
22
67
J01FA06
ATC
roxithromycin; oral
1.6
6.1
216
1590
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.9
6.1
88
510
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.4
6.1
42
184
A06AD11
ATC
lactulose; oral
2.0
6.1
66
348
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.6
6.1
167
1160
XQ800
NOMESCO Finland
Prick test
2.2
6.0
51
244
A07EA06
ATC
budesonide; oral, local oral
2.9
6.0
27
95

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
321
176
39.36
307.65
4.3
1.6
—
—
—
0
0
262
690
6.08
100.64
2.6
2.6
71.09
106.39
ug/g
2.16
218
547
88
124
8.18
60.98
1.3
1.2
—
—
—
0
0
112
243
5.47
50.46
1.5
1.2
—
—
—
0
0
290
1309
3.42
46.74
1.6
1.3
2.06
1.78
u/ml
0.08
54
341
166
530
3.98
45.51
1.3
1.3
—
—
—
0
0
271
1196
3.37
44.93
1.7
1.5
2.07
2.24
g/l
0.99
139
756
149
461
4.00
42.45
1.2
1.2
—
—
—
0
0
71
123
6.43
40.26
1.6
1.3
288.31
304.66
ug/g
0.27
52
64
319
1687
2.97
36.53
6.1
6.6
—
—
—
0
0
390
2459
2.77
29.42
7.1
6.4
54.38
56.91
%
4.55
378
2351
414
2698
2.84
29.13
7.0
6.5
2.10
1.98
e9/l
0.26
342
2390
392
2486
2.76
29.09
7.4
6.5
30.24
28.58
%
2.48
377
2376
155
615
3.07
28.84
1.3
1.2
—
—
—
0
0
406
2638
2.78
28.40
7.1
6.5
0.56
0.56
e9/l
0.07
320
2279
383
2431
2.68
27.85
7.4
6.6
8.66
8.64
%
0.04
367
2287
405
2646
2.74
27.70
7.1
6.5
0.04
0.04
e9/l
0.16
320
2283
381
2424
2.65
27.37
7.4
6.6
0.74
0.69
%
1.06
364
2269
125
455
3.22
26.79
2.0
2.4
29.47
36.31
u/l
1.15
112
390
380
2429
2.62
26.79
7.4
6.5
3.11
2.86
%
1.07
364
2283
411
2747
2.68
26.10
7.2
6.7
0.20
0.19
e9/l
0.52
339
2404
244
1280
2.56
26.04
2.7
2.0
—
—
—
0
0
102
342
3.40
24.89
1.5
1.2
—
—
—
0
0
418
2907
2.55
22.89
9.3
9.6
3.94
3.99
e9/l
0.07
339
2536
355
2301
2.39
22.68
10.3
10.7
0.00
0.00
e9/l
0.44
242
1862
480
3692
2.70
19.17
9.1
7.5
70.93
78.48
u/l
3.95
463
3488
223
1273
2.22
18.19
2.9
2.9
—
0.00
estimate
—
0
7
306
1994
2.13
17.60
5.2
4.6
36.60
36.47
g/l
0.16
289
1894
287
1826
2.13
17.57
4.2
3.6
23.12
83.11
e6/l
3.49
170
1202
367
2602
2.11
16.40
4.2
3.1
87.92
96.75
ug/l
0.45
351
2462
223
1322
2.11
16.11
3.3
2.9
0.20
0.36
e6/l
1.32
138
932
157
822
2.25
15.45
3.0
2.7
0.45
0.97
e6/l
3.60
66
430
298
2038
1.95
13.81
2.4
2.0
93.78
96.32
pmol/l
0.39
157
1092
144
765
2.17
13.46
3.0
2.9
1.18
2.31
e6/l
2.68
53
376
59
208
3.04
13.01
2.4
2.4
—
—
—
0
0
114
559
2.29
12.92
2.5
2.8
8.82
6.70
umol/l
0.46
96
491
238
1540
1.92
12.74
3.4
3.0
34.58
55.25
e6/l
0.66
158
1133
338
2454
1.90
12.64
6.5
6.4
12.07
10.83
umol/l
0.84
323
2347
197
1237
1.89
11.27
2.8
2.2
2.48
2.78
mg/l
1.16
174
1077
282
1981
1.82
11.25
2.2
2.1
—
—
—
0
0
225
1489
1.83
10.80
5.5
6.0
—
—
—
0
0
314
2296
1.80
10.80
2.9
2.4
79.57
75.23
nmol/l
1.89
287
2109
152
890
1.96
10.64
2.7
2.7
2.42
2.44
mmol/l
1.36
133
802
192
1218
1.86
10.51
3.6
3.4
—
0.09
—
0
11
135
778
1.96
9.81
2.8
2.3
14.61
13.77
umol/l
0.50
129
725
209
1386
1.79
9.75
3.6
3.8
7.39
7.40
ph
1.71
140
957
421
3446
1.80
9.03
5.7
4.1
—
2.90
—
0
9
125
723
1.93
8.92
2.8
2.3
2.33
2.39
g/l
0.55
115
666
550
4974
2.87
8.57
18.3
13.1
21.86
21.86
mg/l
0.00
446
3993
231
1646
1.67
7.96
3.0
3.0
2.35
2.36
mmol/l
0.29
213
1508
302
2323
1.62
7.55
6.7
7.1
1.21
1.21
mmol/l
0.04
276
2021
276
2081
1.62
7.46
5.3
6.6
1.21
1.22
mmol/l
0.17
266
1934
83
443
2.02
7.40
1.4
1.5
—
—
—
0
0
72
365
2.11
7.36
2.7
2.5
34.32
16.18
au/ml
—
10
33
35
127
2.87
7.36
1.1
1.2
—
—
—
0
0
68
339
2.14
7.26
1.4
1.3
36.59
34.46
au/ml
—
7
29
23
65
3.64
7.21
1.1
1.1
—
—
—
0
0
153
1009
1.70
6.90
2.6
2.4
5.76
7.00
e6/l
0.32
132
903
203
1449
1.62
6.69
2.9
2.4
55.65
64.99
u/l
1.22
193
1353
77
416
1.98
6.62
3.0
2.8
10.96
10.25
g/l
0.82
65
387
45
196
2.40
6.61
1.8
1.6
7.27
9.49
u/ml
0.34
12
44
281
2178
1.56
6.44
3.8
3.2
6.15
6.20
ph
0.28
136
1242
189
1344
1.60
6.25
1.8
1.6
21.68
20.74
nmol/l
0.43
168
1150
134
875
1.69
6.20
3.5
2.7
549.67
541.55
mosm/kgh2o
0.15
108
758
155
1052
1.64
6.19
1.3
1.3
27.76
33.63
iu/ml
0.32
33
314
14
21
6.80
6.06
1.1
1.1
—
—
—
0
0
542
4986
2.24
6.03
18.5
15.0
3.88
3.95
mmol/l
9.14
537
4879
541
4979
2.20
5.92
18.1
14.9
139.57
139.72
mmol/l
0.85
536
4884
30
115
2.70
5.73
1.4
1.3
254.45
229.95
u/ml
0.16
20
60
518
4710
1.90
5.64
6.4
5.2
1.73
1.84
mu/l
1.64
499
4412
40
181
2.30
5.42
1.6
2.3
1.29
1.37
g/l
0.21
33
164
36
159
2.35
5.16
1.1
1.1
0.48
9.63
eliau/ml
—
6
25
328
2710
1.48
5.10
4.5
3.6
0.00
0.57
estimate
0.51
54
536
62
341
1.92
5.07
1.7
1.7
1.19
1.41
g/l
0.75
56
320
323
2663
1.48
5.06
4.4
3.5
0.00
0.00
estimate
0.50
56
554
139
964
1.58
4.97
1.3
1.3
4.40
11.35
u/ml
1.39
49
367
159
1139
1.54
4.92
1.9
1.9
1.57
1.14
mg/l
0.58
119
879
96
608
1.69
4.92
1.4
1.4
—
—
—
0
0
126
856
1.60
4.91
3.7
3.7
1159.30
381.91
ng/l
0.32
87
603
115
764
1.63
4.90
1.4
1.4
538.18
438.30
titre
0.17
22
165
22
78
2.89
4.87
1.2
1.1
—
—
—
0
0
114
758
1.63
4.84
4.0
3.6
0.83
0.83
mmol/l
0.19
109
734
453
4027
1.56
4.73
5.0
4.3
14.45
14.59
pmol/l
0.66
428
3740
104
683
1.64
4.63
2.1
1.6
—
—
—
0
0
167
1227
1.51
4.55
2.5
2.3
—
—
—
0
0
322
2692
1.44
4.45
4.5
3.5
0.00
0.00
estimate
-0.00
54
562
44
229
2.00
4.23
2.0
1.6
—
—
—
0
0
209
1626
1.44
4.21
2.6
2.2
—
—
—
0
0
401
3511
1.46
4.19
3.7
3.1
36.67
42.03
u/l
0.69
379
3344
16
52
3.14
4.11
1.1
1.2
—
—
—
0
0
52
290
1.87
4.10
1.1
1.1
—
—
—
0
0
221
1744
1.43
4.10
3.2
3.0
32.74
30.04
u/l
0.41
211
1651
11
22
5.07
4.02
5.1
2.2
0.55
0.77
index
0.60
11
22
15
48
3.18
3.95
1.1
1.1
—
—
—
0
0
16
54
3.02
3.87
1.6
1.3
—
—
—
0
0
75
474
1.67
3.87
2.6
3.3
1.52
1.77
%
3.10
64
437
39
201
2.01
3.87
1.1
1.3
—
—
—
0
0
143
1053
1.47
3.78
1.8
1.7
—
—
—
0
0
23
96
2.45
3.77
1.1
1.1
0.94
3.20
eliau/ml
—
9
45
20
78
2.62
3.75
1.2
1.0
—
—
—
0
0
284
2370
1.39
3.71
2.9
2.7
—
—
estimate
—
0
0
24
104
2.36
3.64
1.4
1.5
166.89
148.80
au/ml
—
9
28
39
208
1.94
3.53
1.4
1.3
—
—
—
0
0
252
2077
1.38
3.48
2.0
1.9
1.14
1.34
mmol/l
5.31
219
1785
25
113
2.27
3.46
4.2
2.7
3.50
1.76
index
0.84
14
58
25
115
2.23
3.33
1.4
1.5
—
—
—
0
0
10
23
4.40
3.32
1.0
1.2
158.08
149.06
nmol/l
—
10
23
53
322
1.71
3.18
2.9
3.4
4.49
4.59
pmol/l
0.39
42
284
323
2799
1.35
3.11
4.4
5.0
6.27
6.52
mmol/l
1.35
307
2601
59
376
1.63
2.97
1.8
1.5
—
—
—
0
0
60
387
1.61
2.89
1.2
1.3
185.07
219.62
u/ml
0.21
52
352
94
675
1.47
2.79
1.9
1.7
1053.02
1157.21
nmol/l
0.55
66
518
175
1401
1.36
2.79
2.3
2.1
121.01
239.32
u/l
1.71
166
1329
9
23
3.96
2.78
1.1
1.5
0.53
0.47
e9/l
—
9
23
15
62
2.46
2.56
2.3
1.3
—
—
—
0
0
40
240
1.72
2.55
1.3
2.1
7.72
7.57
iu/ml
—
5
55
17
75
2.30
2.53
3.7
2.8
2.54
3.00
mmol/l
—
8
45
12
45
2.70
2.46
1.0
1.1
—
—
—
0
0
62
420
1.53
2.45
1.1
1.3
137.81
146.96
u/ml
0.04
11
187
10
32
3.16
2.44
1.0
1.3
—
—
—
0
0
75
530
1.48
2.43
2.0
2.0
368.72
375.02
nmol/l
0.11
69
501
147
1169
1.34
2.41
4.3
3.9
—
—
—
0
0
19
90
2.15
2.41
1.4
1.1
—
—
—
0
0
107
810
1.39
2.39
2.6
1.7
—
—
—
0
0
95
705
1.42
2.38
2.0
2.4
29.89
29.11
s
0.84
95
691
499
4705
1.42
2.32
4.9
4.6
5.66
5.79
mmol/l
1.88
467
4372
196
1635
1.30
2.28
1.6
1.5
—
—
—
0
0
21
106
2.02
2.28
1.2
2.0
—
—
—
0
0
58
395
1.52
2.25
3.1
4.5
5.16
18.14
ug/l
0.63
40
323
5
9
5.59
2.21
1.8
1.2
—
—
—
0
0
23
122
1.92
2.19
1.1
1.1
—
—
—
0
0
151
1226
1.31
2.13
2.3
2.8
309.06
333.46
umol/l
2.95
134
1098
54
367
1.52
2.12
2.5
3.2
60.78
71.62
e9/l
1.93
35
273
9
31
2.93
2.08
1.2
1.1
—
—
—
0
0
86
647
1.39
2.00
1.2
1.2
—
—
—
0
0
5
11
4.57
1.94
1.2
2.9
0.64
0.60
mmol/l
—
5
11
21
113
1.89
1.94
2.1
1.8
—
—
—
0
0
38
244
1.60
1.92
1.4
1.5
0.15
0.26
mg/l
1.60
12
108
18
92
1.99
1.92
2.6
3.4
—
—
—
0
0
543
5235
1.54
1.91
14.4
10.9
24.45
25.91
u/l
1.67
535
5100
41
270
1.56
1.87
2.1
2.7
—
—
—
0
0
13
59
2.23
1.85
1.0
2.7
—
—
—
0
0
148
1221
1.28
1.84
2.9
3.3
687.58
1172.50
ng/l
2.94
120
1034
12
53
2.29
1.81
1.0
2.6
—
—
—
0
0
32
201
1.63
1.78
1.2
1.6
—
18.10
—
0
5
74
556
1.38
1.75
2.2
1.6
—
—
—
0
0
55
392
1.45
1.74
5.5
10.3
—
—
—
0
0
29
181
1.63
1.66
2.8
3.7
168.29
239.86
mg/l
0.96
14
84
8
31
2.60
1.66
1.9
1.5
188.88
181.38
pmol/l
—
8
31
14
69
2.05
1.66
1.1
1.3
—
72.54
—
0
5
537
5190
1.44
1.59
13.6
11.6
—
—
—
0
0
163
1385
1.25
1.57
3.2
2.8
—
—
—
0
0
37
249
1.52
1.57
1.1
1.1
—
—
—
0
0
16
85
1.91
1.56
1.3
1.4
0.83
0.56
nmol/l
0.46
16
80
8
33
2.44
1.54
1.1
1.1
—
—
—
0
0
6
21
2.88
1.51
1.0
1.0
—
—
—
0
0
29
189
1.56
1.43
1.4
1.4
1.13
1.30
mm
0.94
20
132
74
576
1.33
1.42
5.6
8.1
104.82
104.25
mmol/l
0.59
74
576
53
392
1.39
1.40
2.3
2.4
6.21
6.12
ph
0.31
34
261
26
166
1.59
1.39
1.6
1.8
0.94
2.91
ug/l
0.60
20
148
80
633
1.31
1.37
2.2
3.0
3.72
5.29
e9/l
1.57
72
560
6
23
2.62
1.37
1.2
1.2
—
—
—
0
0
6
23
2.62
1.37
1.0
1.1
138.00
190.46
mmol/24h
—
6
23
5
17
2.96
1.36
1.0
2.0
54.40
76.22
ug/l
—
5
17
5
17
2.96
1.36
1.0
1.4
—
—
—
0
0
20
120
1.69
1.36
1.3
1.1
—
—
—
0
0
20
120
1.69
1.36
1.3
1.1
—
—
—
0
0
0
37
0.00
1.35
0.0
15.8
—
920.97
—
0
37
29
192
1.54
1.34
1.4
1.4
—
—
—
0
0
22
136
1.64
1.34
2.0
2.7
—
—
—
0
0
0
39
0.00
1.34
0.0
3.1
—
19.22
—
0
27
64
495
1.33
1.29
1.7
1.7
3.32
3.41
mmol/l
0.29
40
347
24
156
1.56
1.22
1.3
1.1
—
—
—
0
0
29
197
1.50
1.22
1.5
1.5
—
—
—
0
0
29
197
1.50
1.22
1.7
2.1
—
—
—
0
0
5
112
0.44
1.14
1.4
3.8
3.42
3.92
mmol/l
—
5
112
56
435
1.32
1.12
4.9
5.1
1.45
1.92
mmol/l
0.57
50
371
7
31
2.27
1.10
1.7
1.4
—
—
—
0
0
21
136
1.56
1.10
1.0
1.1
1.52
1.44
u/ml
0.03
13
66
19
120
1.60
1.10
1.3
1.9
142.67
192.31
e6/l
0.14
12
94
7
32
2.20
1.08
1.0
1.0
1785.00
1495.41
miu/ml
—
7
32
7
34
2.07
1.03
1.1
1.3
30.83
29.39
nmol/l
—
7
27
21
139
1.53
1.01
1.0
1.1
3.02
6.18
u/ml
0.76
16
83
190
1703
1.17
1.01
3.8
3.2
23.75
36.58
ng/l
1.25
101
1102
47
601
0.76
1.00
1.3
1.3
—
—
—
0
0
18
116
1.57
0.97
2.1
4.1
1.48
2.02
ratio
—
6
66
559
5491
1.44
0.96
27.1
20.4
4.48
4.52
e12/l
1.40
549
5383
11
62
1.79
0.94
1.4
1.4
—
—
—
0
0
77
639
1.24
0.94
2.0
1.8
—
—
—
0
0
559
5493
1.43
0.93
27.2
20.4
6.51
6.68
e9/l
0.67
550
5381
223
2035
1.16
0.93
4.2
3.4
0.00
0.01
estimate
1.15
51
468
18
118
1.54
0.92
1.2
1.9
43.00
17.00
e6/l
0.27
12
90
57
458
1.27
0.91
5.0
5.0
7.36
7.38
ph
0.90
32
264
14
86
1.64
0.91
4.1
3.7
6.45
7.81
pmol/l
0.44
14
86
31
228
1.38
0.90
1.5
1.4
293.40
254.99
miu/ml
0.20
15
117
11
63
1.76
0.90
3.7
2.6
—
—
—
0
0
87
735
1.22
0.90
3.2
3.1
0.52
0.73
ug/l
3.22
67
462
23
161
1.45
0.88
1.0
1.1
0.83
3.91
u/ml
1.80
18
92
8
43
1.87
0.87
1.1
1.1
119.38
111.53
pmol/l
—
8
43
41
319
1.31
0.85
1.5
1.6
—
—
—
0
0
6
31
1.95
0.84
2.3
3.2
730.33
710.03
u/ml
—
6
31
48
382
1.28
0.84
1.9
1.4
15.61
22.12
iu/l
1.13
39
316
33
249
1.34
0.84
1.4
1.5
69.23
58.49
ug/l
0.57
24
204
11
65
1.71
0.83
1.2
1.2
—
—
—
0
0
558
5490
1.38
0.82
27.2
20.4
253.69
255.58
e9/l
0.29
550
5396
471
4555
1.18
0.82
5.7
5.6
37.23
38.14
mmol/mol
1.83
449
4317
9
149
0.60
0.80
1.2
1.3
—
—
—
0
0
0
24
0.00
0.79
0.0
1.5
—
6.22
—
0
24
20
142
1.42
0.73
1.3
2.3
11.93
12.14
mg/l
0.05
20
133
19
136
1.41
0.67
1.1
1.1
1.45
2.01
u/ml
0.22
14
79
78
673
1.18
0.67
2.3
1.9
—
—
—
0
0
29
224
1.31
0.66
1.2
1.2
—
2.18
—
0
13
7
44
1.60
0.65
1.6
1.7
—
—
—
0
0
42
342
1.25
0.64
4.2
3.6
76.35
75.36
ng/l
0.03
37
311
12
79
1.53
0.63
1.3
1.3
18.73
76.72
mu/l
1.02
12
74
0
20
0.00
0.60
0.0
1.0
—
11.82
—
0
15
0
20
0.00
0.60
0.0
1.3
—
26.95
—
0
20
8
52
1.55
0.59
1.8
5.9
7.04
6.63
mmol/l
—
8
43
21
158
1.34
0.58
2.1
1.8
46.24
40.67
nmol/l
0.38
21
153
49
413
1.20
0.56
6.0
6.1
0.00
0.19
%
1.44
16
98
48
404
1.20
0.56
6.0
5.4
0.40
0.58
%
0.48
21
113
162
1494
1.12
0.56
4.0
3.0
0.00
0.06
estimate
0.60
50
457
10
65
1.55
0.56
1.2
1.2
18.05
25.16
ng/l
—
10
65
6
38
1.58
0.54
1.2
1.5
2.73
2.94
mg/l
—
6
38
497
4866
1.14
0.53
4.9
4.7
4.61
4.68
mmol/l
0.93
481
4584
39
324
1.22
0.52
2.9
2.2
4.63
7.25
ug/l
0.74
31
294
502
4926
1.14
0.48
5.8
5.3
2.72
2.77
mmol/l
0.66
486
4630
7
47
1.50
0.47
1.4
1.1
—
—
—
0
0
5
84
0.59
0.46
1.0
1.1
—
87.88
—
0
17
40
340
1.19
0.44
4.9
4.0
1.21
1.23
mmol/l
1.64
35
296
134
1240
1.10
0.44
4.9
4.7
—
—
—
0
0
21
166
1.27
0.44
1.1
1.2
—
—
—
0
0
198
2095
0.92
0.44
3.0
2.8
—
—
—
0
0
11
78
1.42
0.43
1.2
1.1
—
—
—
0
0
22
176
1.26
0.42
1.2
1.3
—
—
—
0
0
39
333
1.18
0.42
2.7
3.2
—
—
—
0
0
49
427
1.16
0.41
5.7
5.4
0.48
0.95
%
1.29
21
129
5
33
1.52
0.41
1.2
1.0
401.00
250.19
ng/l
—
5
21
5
34
1.47
0.40
3.2
3.5
427.20
799.00
mg
—
5
34
8
61
1.32
0.39
6.6
3.9
1.75
1.19
%
—
8
54
36
307
1.18
0.39
1.9
2.1
5976.49
6301.13
u/l
0.02
14
131
12
158
0.75
0.37
6.0
8.0
—
—
—
0
0
16
125
1.29
0.37
1.5
2.0
—
—
—
0
0
9
71
1.27
0.36
1.0
1.6
—
—
—
0
0
15
117
1.29
0.35
2.2
1.8
191.87
231.04
pmol/l
0.56
15
108
46
405
1.15
0.35
6.0
5.6
0.00
0.14
%
3.07
17
106
48
424
1.14
0.35
1.4
1.6
1022.75
1011.49
mu/l
0.03
39
349
24
200
1.21
0.34
1.4
1.4
8.73
9.82
u/l
0.16
17
149
6
45
1.34
0.34
2.7
13.1
8.47
11.11
%
—
6
45
6
45
1.34
0.34
1.7
1.4
—
—
—
0
0
6
47
1.28
0.32
1.3
1.1
—
—
—
0
0
13
101
1.29
0.32
1.0
1.1
11.92
8.61
u/ml
—
8
45
7
52
1.35
0.31
2.1
2.7
—
—
—
0
0
7
55
1.28
0.30
2.0
2.1
—
—
—
0
0
209
2008
1.06
0.28
13.9
11.5
1.21
1.19
inr
0.22
161
1645
12
94
1.28
0.28
1.0
1.1
0.19
0.54
u/ml
—
6
34
8
65
1.23
0.27
1.4
1.2
—
—
—
0
0
45
405
1.12
0.27
4.6
3.4
—
—
—
0
0
5
73
0.68
0.26
4.4
5.3
293.20
371.40
umol/l
—
5
65
5
75
0.66
0.26
1.6
1.3
—
—
—
0
0
6
82
0.73
0.24
1.5
1.5
—
—
—
0
0
12
97
1.24
0.23
2.3
7.1
47.25
62.43
%
1.93
12
97
21
242
0.86
0.22
2.8
1.9
0.00
0.01
estimate
—
5
87
0
10
0.00
0.21
0.0
1.0
—
7.23
—
0
10
0
12
0.00
0.21
0.0
8.7
—
4.98
—
0
12
45
412
1.10
0.21
4.4
4.0
7.32
7.34
ph
0.17
37
299
24
211
1.14
0.21
1.0
1.1
0.55
0.64
ratio
—
5
23
6
50
1.20
0.19
1.7
1.1
—
—
—
0
0
6
50
1.20
0.19
1.2
1.2
—
—
—
0
0
90
947
0.94
0.18
1.9
1.6
448.94
43489378.06
pmol/l
1.45
79
814
25
279
0.89
0.18
6.6
11.3
0.63
0.65
%
0.06
25
279
43
465
0.92
0.18
5.7
9.9
7.43
7.42
ph
0.53
18
262
12
101
1.19
0.16
1.7
1.2
2.79
2.75
ug/l
0.02
12
92
12
141
0.85
0.16
1.2
1.4
43.50
206.29
pmol/l
1.14
12
134
140
1449
0.96
0.16
3.9
4.0
8.60
9.43
mg/mmol
0.08
81
890
8
71
1.13
0.16
1.0
1.3
—
—
nmol/l
—
0
0
14
122
1.15
0.14
2.2
3.2
60.55
58.35
%
0.35
14
122
12
103
1.17
0.14
1.2
1.2
—
—
—
0
0
43
458
0.93
0.13
5.6
10.0
0.27
0.97
mmol/l
0.65
35
389
47
443
1.07
0.13
2.7
2.0
0.00
0.03
estimate
0.50
11
110
16
179
0.89
0.12
9.0
3.0
23.28
25.23
mmol/l
1.55
16
174
489
4857
1.04
0.11
4.9
4.6
1.49
1.47
mmol/l
0.56
473
4557
141
1446
0.97
0.11
4.5
3.6
0.00
0.01
estimate
0.88
55
529
21
228
0.92
0.10
3.0
6.6
—
—
—
0
0
5
45
1.11
0.10
1.0
1.0
—
—
—
0
0
10
87
1.15
0.09
2.6
3.5
3.87
4.07
e9/l
—
10
87
10
87
1.15
0.09
1.0
1.2
—
—
—
0
0
5
47
1.06
0.09
1.4
1.1
—
—
—
0
0
459
4619
0.97
0.09
4.1
4.0
1.13
1.25
mmol/l
5.20
436
4305
25
267
0.93
0.08
6.0
4.6
135.60
129.20
g/l
0.78
25
261
22
205
1.08
0.08
2.1
1.8
—
—
—
0
0
9
87
1.04
0.07
1.3
1.7
—
—
—
0
0
124
1217
1.02
0.06
3.5
3.4
1.02
1.02
kg/l
0.51
87
792
9
105
0.85
0.06
10.7
4.4
—
—
—
0
0
24
227
1.06
0.06
1.5
1.7
—
—
—
0
0
12
110
1.09
0.05
1.0
1.1
4.22
3.69
u/ml
—
6
56
28
268
1.05
0.04
1.5
1.6
—
—
—
0
0
19
180
1.06
0.04
7.5
3.7
24.90
24.87
mmol/l
0.01
19
173
27
281
0.96
0.04
2.6
2.5
57.69
94.75
u/ml
0.28
27
269
160
1616
0.99
0.03
3.1
3.2
7.96
7.93
mmol/l
0.02
143
1380
30
292
1.03
0.02
1.5
1.6
—
—
—
0
0
23
223
1.03
0.01
6.9
3.3
—
—
—
0
0
22
227
0.97
0.01
1.0
1.1
0.83
0.88
g/l
0.51
22
227
30
293
1.03
0.01
1.5
1.6
—
—
—
0
0
142
1413
1.01
0.00
3.1
3.3
56.46
55.26
mg/l
0.02
83
895
30
294
1.02
0.00
1.5
1.6
—
—
—
0
0
30
295
1.02
0.00
1.5
1.6
—
—
—
0
0
77
773
1.00
0.00
1.6
1.6
—
—
—
0
0
22
221
1.00
0.00
1.0
1.1
1.54
1.57
g/l
0.16
22
221
121
1211
1.00
0.00
5.6
5.2
1.60
2.57
ug/l
1.78
112
1089
0
6
0.00
0.00
0.0
2.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
33.83
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
59.63
—
0
8
5
49
1.02
0.00
3.4
4.6
—
—
—
0
0
7
69
1.01
0.00
2.0
2.1
—
—
—
0
0
0
8
0.00
0.00
0.0
21.5
—
0.42
—
0
8
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
3.3
—
—
—
0
0
6
67
0.89
-0.00
1.5
1.4
—
—
—
0
0
5
56
0.89
-0.00
2.2
2.2
30.80
33.45
pg
—
5
56
0
9
0.00
-0.00
0.0
2.4
—
6371.78
—
0
9
0
5
0.00
-0.00
0.0
3.4
—
198.60
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
4.52
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
72.66
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
1.60
—
0
5
6
67
0.89
-0.00
1.5
1.4
—
—
—
0
0
6
67
0.89
-0.00
1.5
1.4
—
—
—
0
0
6
67
0.89
-0.00
1.5
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_OTHER_PROTOZOAL and mortality.

Females

Parameter HR [95% CI] p-value
AB1_OTHER_PROTOZOAL 1.862 [1.43, 2.42] < 0.001
Birth year 0.997 [0.99, 1.01] 0.498

During the follow-up period (1.1.1998 — 31.12.2019), 137 out of 1428 females with AB1_OTHER_PROTOZOAL died.

Males

Parameter HR [95% CI] p-value
AB1_OTHER_PROTOZOAL 1.772 [1.39, 2.27] < 0.001
Birth year 0.987 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 128 out of 1146 males with AB1_OTHER_PROTOZOAL died.

Mortality risk

Mortality risk for people of age

years, who have AB1_OTHER_PROTOZOAL.

N-year risk Females Males
1 0.177% 0.302%
5 1.094% 1.879%
10 2.787% 4.981%
15 5.699% 9.485%
20 9.974% 15.868%

Relationships between endpoints

Index endpoint: AB1_OTHER_PROTOZOAL – Other protozoal intestinal diseases

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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