glaucoma: Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
372 |
4. Check minimum number of eventsNone |
372 |
5. Include endpointsNone |
372 |
6. Filter based on genotype QC (FinnGen only) |
318 |
Control definitions (FinnGen only)
- Control exclude
- H7_GLAUCOMA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF6
- Parent code in ICD-10
- H40
- Name in latin
- Glaucoma [secundarium] postinflammatorium
Similar endpoints
↥List of similar endpoints to
Glaucoma secondary to eye inflammation
based on the number of shared cases.
Similar with more cases:
- Glaucoma
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2511 | 1296 | 1195 |
| Only index persons | 2084 | 1092 | 992 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 50.74 | 54.42 | 46.51 |
| Only index persons | 47.68 | 51.18 | 43.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 318 | 173 | 145 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.07 |
| Median age at first event (years) | 49.05 | 50.54 | 47.28 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 336
- Matched controls
- 3360
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
S01EC01
ATC
acetazolamide; systemic
184.2
307.9
152
15
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
+∞
307.7
262
*
S01ED51
ATC
timolol, combinations; ophthalmic
222.5
307.7
243
39
S01ED01
ATC
timolol; ophthalmic
229.9
307.7
176
16
114
Kela drug reimbursment
Glaucoma
224.4
307.7
234
34
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
93.6
307.7
200
52
S01EE01
ATC
latanoprost; ophthalmic
101.7
266.5
142
24
H40.0
ICD-10 Finland
Glaucoma suspect
161.1
247.1
123
12
H20.1
ICD-10 Finland
Chronic iridocyclitis
836.9
211.9
187
5
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
+∞
200.8
172
*
S01BA07
ATC
fluorometholone; ophthalmic
73.2
171.7
95
18
S01EA05
ATC
brimonidine; ophthalmic
679.1
164.9
150
*
XCK00
NOMESCO Finland
Perimetry
34.5
162.9
112
48
S01BA01
ATC
dexamethasone; ophthalmic
30.3
149.0
107
51
S01EE05
ATC
tafluprost; ophthalmic
84.3
145.3
78
12
H26.2
ICD-10 Finland
Complicated cataract
94.6
140.3
74
10
S01BA04
ATC
prednisolone; ophthalmic
43.1
139.4
87
27
Z96.1
ICD-10 Finland
Presence of intraocular lens
14.0
133.2
172
234
S01BC03
ATC
diclofenac; ophthalmic
39.9
118.5
75
24
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
56.2
110.9
64
14
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
11.1
101.1
141
205
S01FA04
ATC
cyclopentolate; ophthalmic
62.7
94.2
53
10
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
41.0
93.3
58
17
S01EC04
ATC
brinzolamide; ophthalmic
182.8
92.5
93
7
XCW99
NOMESCO Finland
Other investigative procedure of eye
10.9
85.3
112
148
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
+∞
81.7
75
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
10.0
73.3
100
137
Z01.0
ICD-10 Finland
Examination of eyes and vision
7.3
69.9
148
329
WX140
NOMESCO Finland
Parabulbar anesthesy
13.4
69.4
72
67
S01EA03
ATC
apraclonidine; ophthalmic
172.9
67.8
69
5
XCH00
NOMESCO Finland
Eye pressure measurement
15.3
65.8
62
49
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
18.7
64.7
54
34
L04AX03
ATC
methotrexate; systemic
8.3
63.9
102
167
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
373.2
62.6
61
*
L04AB04
ATC
adalimumab; parenteral
21.4
61.6
48
26
S01EC03
ATC
dorzolamide; ophthalmic
694.9
60.7
58
*
XCK10
NOMESCO Finland
Photography of fundus of eye
8.7
60.2
90
136
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
6.0
59.3
211
734
S01EE03
ATC
bimatoprost; ophthalmic
108.3
58.2
62
7
CJB10
NOMESCO Finland
Laser discission of secondary cataract
7.8
53.3
87
144
H26.4
ICD-10 Finland
After-cataract
7.2
52.2
93
169
L01BA01
ATC
methotrexate; systemic
12.7
51.7
54
50
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
568.0
50.8
49
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
5.4
48.9
228
948
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
5.1
48.5
193
707
S01EX03, ,
ATC
185.9
47.2
48
*
H40.8
ICD-10 Finland
Other glaucoma
514.1
46.5
45
*
S01EE04
ATC
travoprost; ophthalmic
95.4
45.2
49
6
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
14.0
43.5
42
34
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
+∞
42.6
40
*
H40.9
ICD-10 Finland
Glaucoma, unspecified
232.6
40.8
41
*
36401
ICD-8 Finland
Iritis, Iridocyclitis glaucomatosa. Syndroma Posner-Schlossman, heterochromia iridis
+∞
40.4
38
*
3641A
ICD-9 Finland
Disorders of iris and ciliary body, Chronic iridocyclitis
+∞
37.2
35
*
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
+∞
37.2
35
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
12.9
36.7
37
32
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
+∞
35.0
33
*
S01EC54
ATC
brinzolamide, combinations; ophthalmic
373.0
34.6
34
*
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
+∞
33.9
32
*
ZXC20
NOMESCO Finland
Use of chemical agents
14.0
33.6
32
25
S01ED02
ATC
betaxolol; ophthalmic
188.5
33.4
34
*
3656F
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA POST UVEITIDEM]
+∞
32.8
31
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
8.7
32.7
44
57
L88
ICPC
Rheumatoid/seropositive arthritis
9.1
32.3
42
52
3656B
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUKOMASYKLIITTINEN KRIISI,SYNDR POSSNER-SCHOSSMAN]
+∞
31.8
30
*
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
+∞
28.5
27
*
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
305.6
28.2
28
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
4.6
28.2
81
219
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
+∞
27.5
26
*
S01FA01
ATC
atropine; ophthalmic
81.8
27.3
30
*
CHC05
NOMESCO Finland
Iridotomy
65.6
26.4
30
5
CHD99
NOMESCO Finland
Other filtering operation
+∞
26.4
25
*
S01AD03
ATC
aciclovir; ophthalmic
8.9
26.1
34
42
S01FA02
ATC
scopolamine; ophthalmic
31.3
25.9
34
12
H26.3
ICD-10 Finland
Drug-induced cataract
54.7
25.7
30
6
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
6.6
25.0
43
73
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
5.5
24.3
51
105
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
134.6
23.9
25
*
H16.0
ICD-10 Finland
Corneal ulcer
6.0
23.5
45
85
ZXA00
NOMESCO Finland
Right side
3.3
23.3
132
557
3663A
ICD-9 Finland
Cataract secondary to ocular disorders
246.1
22.9
23
*
H02AB06
ATC
prednisolone; systemic
3.1
22.9
211
1173
L04AX01
ATC
azathioprine; systemic
6.6
22.2
38
64
36402
ICD-8 Finland
Iritis, Iridocyclitis, uveitis chronica
+∞
22.1
21
*
H20.8
ICD-10 Finland
Other iridocyclitis
123.1
21.9
23
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
5.5
21.8
46
95
S01EB01
ATC
pilocarpine; ophthalmic
82.2
21.0
23
*
H26.02
ICD-10 Finland
Presenil cataract
9.3
20.9
26
30
H18.1
ICD-10 Finland
Bullous keratopathy
223.3
20.8
21
*
S01EA02
ATC
dipivefrine; ophthalmic
+∞
20.0
19
*
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
78.0
19.9
22
*
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
26.5
19.9
27
11
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
212.0
19.8
20
*
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
24.3
19.4
27
12
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
24.3
19.4
27
12
H30.2
ICD-10 Finland
Posterior cyclitis
106.0
18.8
20
*
XCH05
NOMESCO Finland
Eye pressure longterm registration
200.7
18.7
19
*
A07EC01
ATC
sulfasalazine; oral, rectal
4.3
18.2
51
133
ZXA05
NOMESCO Finland
Left side
2.9
18.2
115
506
37520
ICD-8 Finland
Glaucoma, Secondary
+∞
17.9
17
*
L04AA01
ATC
[U] ciclosporin
25.7
17.6
24
10
M45
ICD-10 Finland
Ankylosing spondylitis
7.6
17.2
25
35
S01BC05
ATC
ketorolac; ophthalmic
5.5
16.9
34
67
3708
FHL
Trabeculectomy or equivalent
+∞
16.8
16
*
H40.6
ICD-10 Finland
Glaucoma secondary to drugs
+∞
16.8
16
*
ZXA10
NOMESCO Finland
Bilateral
3.0
16.0
87
349
H25.1
ICD-10 Finland
Senile nuclear cataract
2.7
16.0
122
586
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
6.6
15.7
26
42
36400
ICD-8 Finland
Iritis, Iridocyclitis acuta
40.1
15.5
19
5
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
5.2
15.3
33
69
Z94.7
ICD-10 Finland
Corneal transplant status
47.3
15.2
18
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.9
14.9
48
138
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
15.1
14.8
24
17
H21.1
ICD-10 Finland
Other vascular disorders of iris and ciliary body
+∞
14.7
14
*
CHD35
NOMESCO Finland
Laser goniopuncture
+∞
14.7
14
*
TCG10
NOMESCO Finland
Removal of sutures from cornea
156.5
14.6
15
*
CFW99
NOMESCO Finland
Other operation on conjunctiva
156.5
14.6
15
*
3640A
ICD-9 Finland
Disorders of iris and ciliary body, Acute and subacute iridocyclitis
156.5
14.6
15
*
S01FA06
ATC
tropicamide; ophthalmic
78.4
13.7
15
*
L04AA17
ATC
[U] adalimumab
+∞
13.6
13
*
CS2P4
NOMESCO Finland
Optic nerve head imaging
+∞
13.6
13
*
H40.20
ICD-10 Finland
Acute glaucoma with closed ventricular angle
+∞
13.6
13
*
H40
ICD-10 Finland
Glaucoma
145.6
13.5
14
*
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
20.0
13.1
19
10
H04.10
ICD-10 Finland
Dry eye syndrome
3.2
12.6
57
204
37403
ICD-8 Finland
Cataract, Complicata
+∞
12.6
12
*
3656X
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA SECUNDARIA ALIA SEU NUD]
+∞
12.6
12
*
H22.1*D86.8
ICD-10 Finland
Iridocyclitis in sarcoidosis
+∞
12.6
12
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
11.8
179
1133
L04AD01
ATC
ciclosporin; systemic
13.2
11.8
20
16
H20
ICD-10 Finland
Iridocyclitis
31.3
11.7
15
5
H221, M084,
ICD-10 Finland
+∞
11.5
11
*
CHD00
NOMESCO Finland
Laser trabeculoplasty
124.1
11.5
12
*
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
44.9
11.0
13
*
XCW10
NOMESCO Finland
Assessment of vision
18.6
10.8
16
9
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.5
10.8
39
121
H11.3
ICD-10 Finland
Conjunctival haemorrhage
4.6
10.7
26
60
H40.11
ICD-10 Finland
Low pressure glaucoma
62.0
10.7
12
*
S01AX11
ATC
[U] ofloxacin
5.1
10.6
23
48
H221, M083,
ICD-10 Finland
+∞
10.5
10
*
H21.0
ICD-10 Finland
Hyphaema
+∞
10.5
10
*
CFD10
NOMESCO Finland
Repair of conjunctiva
+∞
10.5
10
*
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
+∞
10.5
10
*
H57.1
ICD-10 Finland
Ocular pain
4.5
10.3
26
62
H02AB07
ATC
prednisone; oral
2.7
10.2
61
254
H15.1
ICD-10 Finland
Episcleritis
12.7
10.0
17
14
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
12.7
10.0
17
14
Z3231
NOMESCO Finland
Registered nurse
2.2
9.7
107
586
CS494
NOMESCO Finland
Other visual field testing
15.6
9.6
15
10
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
102.8
9.5
10
*
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
102.8
9.5
10
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
102.8
9.5
10
*
L04AB05
ATC
certolizumab pegol; parenteral
31.0
9.5
12
*
S01FB01
ATC
phenylephrine; ophthalmic
+∞
9.4
9
*
H40.22
ICD-10 Finland
Chronic glaucoma with closed ventricular angle
+∞
9.4
9
*
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
11.1
9.4
17
16
H18.8
ICD-10 Finland
Other specified disorders of cornea
37.8
9.1
11
*
71200
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Juvenile rheumatoid arthritis
51.4
8.7
10
*
H22.1*M45
ICD-10 Finland
Iridocyclitis in ankylosing spondylitis
51.4
8.7
10
*
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
3.5
8.6
31
96
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
92.3
8.5
9
*
S01BA09
ATC
clobetasone; ophthalmic
92.3
8.5
9
*
L04AA11
ATC
[U] etanercept
92.3
8.5
9
*
CJD20
NOMESCO Finland
Extracapsular cataract extraction with implantation of artificial lens in posterior chamber
+∞
8.4
8
*
H22.1
ICD-10 Finland
Iridocyclitis in other diseases classified elsewhere
+∞
8.4
8
*
H40.19
ICD-10 Finland
Other primary glaucoma with open ventricular angle
+∞
8.4
8
*
H44.4
ICD-10 Finland
Hypotony of eye
+∞
8.4
8
*
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
8.4
8
*
TCH12
NOMESCO Finland
Sample aspiration from anterior chambre
+∞
8.4
8
*
L04AB06
ATC
golimumab; parenteral
15.0
8.3
13
9
P01BA02
ATC
hydroxychloroquine; oral
2.9
8.2
40
149
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
4.5
7.8
19
44
CA1ME
NOMESCO Finland
Ultrasound oculometry
18.9
7.6
11
6
WX142
NOMESCO Finland
Sub-tenon anesthesy
25.7
7.6
10
*
CG2T4
NOMESCO Finland
Topography assessment of cornea
10.4
7.6
14
14
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
3.7
7.6
24
68
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
81.8
7.4
8
*
H18.4
ICD-10 Finland
Corneal degeneration
81.8
7.4
8
*
H18.2
ICD-10 Finland
Other corneal oedema
81.8
7.4
8
*
L04AA13
ATC
[U] leflunomide
6.5
7.3
18
29
S01EE51
ATC
latanoprost and netarsudil; ophthalmic
+∞
7.3
7
*
CHB99
NOMESCO Finland
Other operation on anterior chamber and anterior chamber angle
+∞
7.3
7
*
H22.0*B00.5
ICD-10 Finland
Herpesviral iridocyclitis
+∞
7.3
7
*
7143D
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Juvenile chronic polyarthritis[OLIGARTHRITIS JUVENILIS]
+∞
7.3
7
*
M08.9
ICD-10 Finland
Juvenile arthritis, unspecified
+∞
7.3
7
*
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
30.7
7.2
9
*
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
20.5
7.2
10
5
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
7.2
125
796
H33.0
ICD-10 Finland
Retinal detachment with retinal break
4.4
7.1
18
43
H16.9
ICD-10 Finland
Keratitis, unspecified
7.8
7.0
15
20
ZXE00
NOMESCO Finland
One hour or less
1.9
6.9
134
882
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
11.3
6.8
12
11
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
17.1
6.8
10
6
H35.36
ICD-10 Finland
Macular cyst
17.1
6.8
10
6
ZXD20
NOMESCO Finland
Day surgery
2.4
6.7
51
236
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
3.1
6.5
27
91
H27.1
ICD-10 Finland
Dislocation of lens
71.1
6.4
7
*
S01BC01
ATC
indometacin; ophthalmic
71.1
6.4
7
*
H25.0
ICD-10 Finland
Senile incipient cataract
3.0
6.4
29
103
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
6.4
89
523
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
9.5
6.3
12
13
S01XA18
ATC
ciclosporin; ophthalmic
18.4
6.3
9
5
3711
FHL
Cyclodiateria or cryocoagulation
+∞
6.3
6
*
CFB00
NOMESCO Finland
Suture of conjunctiva
+∞
6.3
6
*
H54.4
ICD-10 Finland
Blindness, monocular
+∞
6.3
6
*
CK2P4
NOMESCO Finland
Optic nerve head light layer imaging (OCT)
+∞
6.3
6
*
CGG60
NOMESCO Finland
Reinforcement of sclera using graft
+∞
6.3
6
*
3719
FHL
Other measure in this category
+∞
6.3
6
*
37510
ICD-8 Finland
Glaucoma, Chronicum simplex
+∞
6.3
6
*
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
+∞
6.3
6
*
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
27.2
6.3
8
*
WX002
NOMESCO Finland
Sedation and analgesia
2.1
6.2
69
374
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
234
1607
2.50
13.42
13.6
10.4
4.04
4.06
e9/l
0.05
215
1400
34
88
4.19
12.15
1.6
1.5
1.38
0.07
iu/ml
—
9
18
212
1490
2.15
10.14
4.9
3.9
0.00
5.01
estimate
0.50
48
324
210
1474
2.13
10.04
4.9
3.9
0.00
0.00
estimate
-0.00
49
318
211
1495
2.11
9.69
4.9
4.0
0.05
0.02
estimate
0.19
44
302
18
34
5.53
6.56
1.0
1.1
—
—
—
0
0
252
2043
1.93
6.37
8.0
4.2
12.24
11.86
mm/h
0.19
246
1889
160
1138
1.78
6.18
4.7
3.8
0.00
0.01
estimate
0.80
40
262
123
839
1.74
5.31
3.9
3.3
0.03
0.00
estimate
0.39
38
252
178
1371
1.63
4.68
7.7
7.7
1.21
1.21
mmol/l
0.16
152
1192
71
431
1.82
4.48
2.3
2.2
2.35
2.32
g/l
0.18
63
400
249
2109
1.70
4.32
11.0
8.2
80.56
78.28
u/l
0.21
243
1991
74
463
1.77
4.21
2.4
2.3
11.88
13.41
umol/l
1.08
69
432
27
117
2.42
4.13
2.2
2.3
8.57
5.80
iu/ml
—
6
28
19
69
2.86
4.09
1.4
1.3
—
—
—
0
0
9
14
6.57
4.01
1.0
1.0
1457.89
1585.14
miu/ml
—
9
14
14
38
3.80
3.84
1.4
1.3
—
—
—
0
0
8
12
6.80
3.69
1.6
1.6
533.88
1016.33
u/ml
—
8
12
157
1225
1.53
3.58
2.8
2.4
78.92
76.88
nmol/l
0.41
143
1101
95
662
1.61
3.57
5.1
4.0
1.02
1.02
kg/l
1.41
74
432
114
838
1.55
3.38
4.7
4.0
0.00
0.00
estimate
0.50
45
293
157
1240
1.50
3.30
6.2
7.0
1.21
1.21
mmol/l
0.09
147
1133
161
1280
1.50
3.27
16.7
13.4
1.24
1.25
inr
0.07
134
1053
153
1207
1.49
3.21
4.8
5.1
35.92
35.74
g/l
0.17
139
1142
18
73
2.55
3.18
2.2
1.9
2.19
4.64
iu/l
—
8
26
77
523
1.61
3.18
1.3
1.3
79.98
43.76
iu/ml
0.34
15
157
9
20
4.59
3.13
1.8
1.8
—
—
—
0
0
5
5
10.12
2.99
1.4
1.4
—
—
—
0
0
17
72
2.43
2.77
1.7
1.6
—
—
—
0
0
15
60
2.57
2.74
1.1
1.3
—
—
—
0
0
124
974
1.43
2.52
4.0
3.2
45.85
31.01
u/l
0.39
118
934
293
2708
1.64
2.40
22.2
16.1
21.83
24.13
mg/l
0.56
251
2233
45
291
1.63
2.26
3.2
3.2
—
—
—
0
0
51
342
1.58
2.21
2.5
1.9
—
—
—
0
0
66
471
1.50
2.17
1.8
1.6
1311.85
1214.82
nmol/l
0.34
53
358
48
324
1.56
2.03
2.6
2.0
—
—
—
0
0
8
26
3.13
2.02
1.5
1.3
—
—
—
0
0
9
32
2.86
2.01
1.1
1.4
—
—
—
0
0
7
22
3.23
1.89
2.1
1.3
123.14
91.00
pmol/l
—
7
22
14
66
2.17
1.84
1.8
1.4
—
—
—
0
0
34
217
1.63
1.82
3.1
2.6
69.27
64.96
ml/min/173m2
0.20
11
95
15
74
2.08
1.78
1.2
1.5
15.60
125.00
e6/l
—
10
56
29
179
1.68
1.76
4.9
9.5
24.80
24.90
mmol/l
0.07
29
179
9
36
2.54
1.75
1.0
1.3
—
—
—
0
0
107
864
1.35
1.75
3.4
3.3
1903.48
1374.48
ng/l
0.43
95
728
62
458
1.43
1.72
2.4
2.1
—
—
—
0
0
69
521
1.41
1.69
5.3
4.0
182.30
108.03
ng/l
0.34
53
402
16
83
1.97
1.67
2.8
1.6
0.20
0.23
g/l
0.41
16
83
47
334
1.47
1.59
6.4
10.0
1.06
1.00
mmol/l
0.04
37
279
17
92
1.89
1.59
2.3
2.8
—
—
—
0
0
7
26
2.73
1.59
1.3
1.5
313.14
315.77
u/l
—
7
26
6
20
3.04
1.59
1.0
1.0
—
—
—
0
0
6
142
0.41
1.56
1.2
1.3
—
—
—
0
0
8
33
2.46
1.54
1.0
1.2
—
—
—
0
0
16
86
1.90
1.53
2.8
1.6
1.17
1.15
g/l
0.13
16
86
62
469
1.39
1.51
1.2
1.3
54.40
13.88
u/ml
1.03
23
181
14
73
1.96
1.46
1.2
1.4
1.13
15.61
e6/l
—
8
54
96
788
1.31
1.37
3.5
3.1
0.11
0.32
e6/l
3.82
72
579
79
632
1.33
1.35
2.0
1.8
1.14
1.40
mg/l
0.55
66
501
192
1722
1.27
1.35
3.4
3.2
—
—
—
0
0
86
701
1.30
1.29
3.2
2.9
351.52
345.09
umol/l
0.23
73
611
11
55
2.03
1.29
1.4
1.7
—
—
—
0
0
185
1658
1.26
1.28
5.2
5.6
6.78
6.65
mmol/l
0.33
180
1566
6
25
2.42
1.25
1.5
2.2
13.33
13.23
%
—
6
25
14
78
1.83
1.23
1.1
1.3
—
—
—
0
0
307
2948
1.48
1.21
34.2
24.2
258.84
249.59
e9/l
1.29
302
2905
89
738
1.28
1.17
2.8
2.1
3.06
2.84
mg/l
0.34
79
639
307
2951
1.47
1.17
34.1
24.1
4.46
4.49
e12/l
0.62
300
2896
229
2120
1.25
1.12
4.9
4.1
15.16
14.72
pmol/l
2.06
214
1930
56
440
1.33
1.09
3.6
3.0
1.25
1.77
e6/l
0.40
30
220
10
52
1.95
1.07
1.5
1.7
—
—
—
0
0
168
1510
1.23
1.07
6.6
6.7
12.65
11.58
umol/l
0.32
162
1441
23
155
1.52
1.04
2.8
2.0
—
—
—
0
0
5
22
2.29
1.03
1.0
2.0
161.20
173.76
e6/l
—
5
17
37
277
1.38
0.99
1.9
2.4
39.37
30.10
u/l
1.17
30
229
103
887
1.23
0.97
2.6
2.7
60.03
66.59
u/l
0.40
93
827
59
478
1.28
0.94
3.5
2.8
0.66
0.97
e6/l
0.91
33
255
6
29
2.09
0.89
4.3
4.4
—
—
—
0
0
124
1099
1.20
0.87
4.1
4.0
23.49
39.90
ng/l
1.97
86
773
6
32
1.89
0.82
1.0
1.1
—
—
—
0
0
134
1204
1.19
0.80
2.3
2.1
93.92
95.68
pmol/l
0.16
79
624
272
2602
1.24
0.80
21.9
15.3
83.41
81.78
ml/min/173m2
0.58
256
2399
43
342
1.30
0.80
2.2
2.8
7.77
6.78
umol/l
0.20
35
306
0
24
0.00
0.79
0.0
1.1
—
38.25
—
0
15
0
24
0.00
0.79
0.0
1.0
—
605.33
—
0
15
5
96
0.51
0.79
1.2
1.1
1.46
1.57
g/l
—
5
96
11
67
1.66
0.76
1.7
1.7
—
—
—
0
0
9
145
0.61
0.71
1.4
1.7
1340.34
852.58
mu/l
—
9
127
5
26
1.94
0.71
1.6
1.2
—
—
—
0
0
9
58
1.57
0.70
1.9
1.5
—
—
—
0
0
35
276
1.30
0.70
3.1
1.9
312.69
374.11
nmol/l
1.19
35
261
5
27
1.86
0.68
1.4
1.8
—
—
—
0
0
263
2520
1.20
0.68
5.7
5.1
1.98
1.91
mu/l
0.42
242
2317
7
43
1.64
0.67
1.9
1.9
—
—
—
0
0
5
28
1.80
0.66
1.6
1.2
—
—
—
0
0
5
28
1.80
0.66
1.6
1.2
—
—
—
0
0
145
1330
1.16
0.65
3.4
2.9
101.50
114.37
ug/l
0.49
140
1240
22
164
1.37
0.64
1.7
2.0
—
—
—
0
0
64
549
1.20
0.63
1.5
1.7
—
—
—
0
0
25
191
1.33
0.63
9.1
10.6
94.50
94.39
%
0.05
25
191
67
578
1.20
0.63
1.8
1.8
391.16
440.50
pmol/l
1.33
55
501
25
192
1.33
0.61
1.6
2.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.7
—
185.19
—
0
20
123
1120
1.15
0.60
2.0
2.0
1.34
1.36
mmol/l
0.10
101
946
8
52
1.55
0.60
1.8
1.8
—
—
—
0
0
6
36
1.68
0.57
1.0
1.1
—
—
—
0
0
13
90
1.46
0.56
1.7
1.6
2.88
7.17
u/ml
—
5
20
6
38
1.59
0.54
1.0
1.1
—
—
—
0
0
9
62
1.46
0.53
1.2
1.3
—
—
—
0
0
6
98
0.61
0.53
1.3
1.1
0.83
0.92
g/l
—
6
98
12
84
1.44
0.50
1.6
1.8
—
—
—
0
0
7
48
1.47
0.47
1.1
1.3
—
—
—
0
0
7
48
1.47
0.47
1.1
1.3
—
—
—
0
0
7
49
1.44
0.46
3.0
2.2
7.71
8.47
pmol/l
—
7
49
262
2538
1.15
0.45
7.0
6.2
39.89
39.33
mmol/mol
0.40
250
2404
18
139
1.31
0.44
1.7
1.4
—
—
—
0
0
5
31
1.62
0.43
1.6
1.2
—
—
—
0
0
5
34
1.48
0.40
1.6
1.2
—
—
—
0
0
11
148
0.73
0.39
5.1
3.2
30.61
38.05
u/ml
0.21
11
143
18
142
1.28
0.39
1.1
1.0
—
—
—
0
0
103
954
1.11
0.38
3.3
3.5
2.37
2.36
mmol/l
0.29
96
863
11
81
1.37
0.36
1.6
1.8
—
—
—
0
0
6
41
1.47
0.36
1.2
1.7
—
—
—
0
0
23
190
1.23
0.36
3.4
3.9
130.04
130.36
g/l
0.02
23
182
95
880
1.11
0.35
6.3
5.3
3.82
2.53
ug/l
0.58
86
789
33
284
1.18
0.34
3.1
3.8
1.15
1.51
mmol/l
0.28
28
237
266
2599
1.11
0.31
4.9
5.0
5.86
5.93
mmol/l
0.40
250
2411
29
335
0.85
0.31
4.0
4.8
34.78
31.98
%
0.55
18
222
69
637
1.10
0.28
1.3
1.3
0.70
1.69
u/ml
1.58
19
172
76
706
1.10
0.27
5.3
4.5
19.99
22.20
%
0.69
45
339
12
95
1.27
0.26
1.7
1.2
—
—
—
0
0
5
73
0.68
0.26
1.0
1.1
—
5.37
—
0
11
27
308
0.87
0.25
8.8
7.4
—
—
—
0
0
270
2649
1.10
0.25
4.9
4.9
1.47
1.45
mmol/l
0.27
254
2476
10
78
1.29
0.24
3.4
3.1
9.19
2.04
index
—
5
45
6
81
0.74
0.24
1.2
1.2
—
—
—
0
0
6
81
0.74
0.24
1.2
1.2
—
—
—
0
0
275
2702
1.10
0.24
5.6
5.7
2.62
2.72
mmol/l
1.03
261
2526
5
38
1.32
0.23
1.2
1.3
6.54
7.24
mmol/l
—
5
30
33
295
1.13
0.23
3.2
3.9
5.93
5.68
kpa
0.84
33
284
27
305
0.88
0.23
1.4
2.0
3.25
3.51
ratio
0.60
19
245
95
901
1.08
0.21
4.5
4.0
9.91
9.59
mg/mmol
0.03
59
566
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
56.96
—
0
14
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
27
300
0.89
0.18
2.6
4.7
8.77
8.93
ug/l
0.01
19
248
16
138
1.17
0.18
4.3
3.3
24.69
24.57
mmol/l
0.04
16
131
20
176
1.14
0.18
1.1
1.2
18.94
114.58
u/ml
—
7
60
20
225
0.88
0.17
1.4
1.9
3.35
3.49
mmol/l
0.23
12
166
6
77
0.78
0.16
1.3
1.7
82.23
53.93
ug/l
—
6
67
6
77
0.78
0.16
1.2
1.2
—
—
—
0
0
33
358
0.91
0.15
1.9
2.2
—
—
—
0
0
7
89
0.78
0.14
1.7
1.4
—
—
—
0
0
20
179
1.12
0.14
4.3
3.5
2.19
1.73
mmol/l
0.08
15
130
15
168
0.89
0.12
2.6
3.3
0.46
0.61
%
1.70
15
168
23
212
1.09
0.10
3.9
3.4
5.14
5.15
kpa
0.02
23
206
55
527
1.05
0.10
3.6
3.2
0.70
0.81
ug/l
0.69
39
325
7
67
1.05
0.08
1.4
1.9
—
—
—
0
0
6
75
0.80
0.07
1.0
1.1
—
3.12
—
0
12
9
84
1.07
0.07
1.4
1.5
—
—
—
0
0
10
89
1.13
0.07
1.1
1.4
325.38
299.67
ug/g
—
5
53
9
101
0.89
0.06
2.8
1.7
—
—
—
0
0
9
102
0.88
0.06
1.6
1.9
—
—
—
0
0
82
801
1.03
0.06
1.9
1.7
20.49
21.00
nmol/l
0.12
71
670
21
223
0.94
0.06
1.6
1.4
—
—
—
0
0
192
1900
1.02
0.06
3.3
3.2
59.10
46.94
u/l
0.69
182
1807
268
2663
1.03
0.05
5.1
5.0
4.56
4.63
mmol/l
0.49
254
2499
134
1325
1.02
0.04
2.9
2.8
—
—
estimate
—
0
0
41
420
0.97
0.03
1.4
1.5
—
—
—
0
0
25
258
0.97
0.02
3.4
3.6
4.37
4.34
kpa
0.03
25
249
11
103
1.07
0.02
1.4
1.6
—
—
—
0
0
54
548
0.98
0.01
3.4
2.8
2.46
2.45
mmol/l
0.20
47
495
253
2537
0.99
0.01
4.2
4.2
1.28
1.27
mmol/l
0.05
239
2352
19
195
0.97
0.00
2.2
1.6
—
—
—
0
0
68
676
1.01
0.00
2.3
2.4
—
—
—
0
0
10
104
0.96
0.00
1.6
2.1
—
—
—
0
0
24
244
0.98
0.00
2.1
2.6
10.78
12.98
nmol/l
0.60
17
226
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
60
1.00
-0.00
1.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
63.43
—
0
8
0
9
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
33
330
1.00
-0.00
1.7
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
81
0.99
-0.00
1.5
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
9
89
1.01
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
13.2
—
10.82
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
7
75
0.93
-0.00
1.3
1.7
—
—
—
0
0
9
96
0.94
-0.00
1.8
1.5
522.00
285.37
mu/l
—
9
88
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLAUCSECINFLAM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLAUCSECINFLAM | 1.399 [1.15, 1.7] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.129 |
During the follow-up period (1.1.1998 — 31.12.2019), 148 out of 753 females with H7_GLAUCSECINFLAM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLAUCSECINFLAM | 1.0 [0.79, 1.26] | 0.997 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 629 males with H7_GLAUCSECINFLAM died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLAUCSECINFLAM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.159% | 0.192% |
| 5 | 0.754% | 1.124% |
| 10 | 1.798% | 2.812% |
| 15 | 3.606% | 5.501% |
| 20 | 6.519% | 9.447% |
Relationships between endpoints
↥Index endpoint: H7_GLAUCSECINFLAM – Glaucoma secondary to eye inflammation
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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