Severe mental retardation

F5_SEVRET

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F72
  • Hospital discharge: ICD-9 3181
  • Hospital discharge: ICD-8 313
  • Cause of death: ICD-10 F72
  • Cause of death: ICD-9 3181
  • Cause of death: ICD-8 313

2 out of 7 registries used, show all original rules.

111

4. Check minimum number of events

None

111

5. Include endpoints

None

111

6. Filter based on genotype QC (FinnGen only)

94

Control definitions (FinnGen only)

Control exclude
F5_MENTRET

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F70-F79
Name in latin
Retardatio mentalis gravis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5092 2194 2897
Only index persons 4034 1735 2299
Unadjusted period prevalence (%)
Whole population 0.07 0.06 0.08
Only index persons 0.08 0.06 0.09
Median age at first event (years)
Whole population 23.02 24.33 22.03
Only index persons 22.29 23.33 21.50

-FinnGen-

Key figures

All Female Male
Number of individuals 94 36 58
Unadjusted period prevalence (%) 0.02 0.01 0.03
Median age at first event (years) 18.93 16.65 20.34

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
98
Matched controls
980
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F72.0
ICD-10 Finland
Severe mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
76.3
63
*
N03AG01
ATC
valproic acid; systemic, rectal
26.9
54.8
45
30
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
21.1
49.5
47
41
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
44.1
39
*
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
12.9
35.2
46
63
N05BA01
ATC
diazepam; systemic, rectal
13.4
33.9
41
50
P85
ICPC
Mental retardation
+∞
33.2
30
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
12.1
28.9
36
45
N05BA09
ATC
clobazam; oral
54.2
28.4
33
9
F72.1
ICD-10 Finland
Severe mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
26.2
24
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
37.4
26.1
33
13
183
Kela drug reimbursment
Lamotrigin and topiramate
64.1
24.9
28
6
F79.9
ICD-10 Finland
Unspecified mental retardation, without mention of impairment of behaviour
+∞
22.8
21
*
N05CD08
ATC
midazolam; nasal, systemic
23.0
22.7
33
21
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
24.8
21.3
30
17
N03AX11
ATC
topiramate; oral
32.9
19.4
25
10
F71.0
ICD-10 Finland
Moderate mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
19.4
18
*
N03AX14
ATC
levetiracetam; systemic
19.1
18.8
29
21
F72.9
ICD-10 Finland
Severe mental retardation, without mention of impairment of behaviour
+∞
18.3
17
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
7.9
17.9
30
52
G40.4
ICD-10 Finland
Other generalized epilepsy and epileptic syndromes
77.5
17.4
19
*
L28
ICPC
Limited function/disability (L)
6.7
16.1
32
66
113
Kela drug reimbursment
Anxiety disorders associated with mental retardation
+∞
16.1
15
*
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
+∞
15.0
14
*
N05AX08
ATC
risperidone; systemic
6.7
14.9
29
58
N03AG04
ATC
vigabatrin; oral
175.0
14.9
15
*
N03AX09
ATC
lamotrigine; oral
14.8
14.9
25
22
N03AF02
ATC
oxcarbazepine; oral
15.5
14.6
24
20
R56.8
ICD-10 Finland
Other and unspecified convulsions
7.0
14.4
26
48
A06AD11
ATC
lactulose; oral
6.5
14.1
28
57
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
6.7
14.1
27
53
N03AF01
ATC
carbamazepine; oral, rectal
22.4
14.1
20
11
J18.9
ICD-10 Finland
Pneumonia, unspecified
5.0
13.9
48
159
G40.89
ICD-10 Finland
Other epilepsy
33.8
13.5
17
6
F73.0
ICD-10 Finland
Profound mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
12.8
12
*
M41.4
ICD-10 Finland
Neuromuscular scoliosis
+∞
12.8
12
*
181
Kela drug reimbursment
Retigabine and vigabatrin
148.2
12.8
13
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
4.9
12.6
38
112
RT274, ,
NOMESCO Finland
+∞
11.7
11
*
Z31.5
ICD-10 Finland
Genetic counselling
6.6
11.4
21
39
U04
ICPC
Incontinence urine
24.9
11.1
15
7
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
5.8
10.9
23
49
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.9
10.7
29
77
F79.1
ICD-10 Finland
Unspecified mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
10.6
10
*
R5110, ,
SPAT
12.1
10.6
19
19
SPAT1262
SPAT
Handing over of treatment supplies
5.4
10.3
24
56
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
19.4
10.2
15
9
H50.30
ICD-10 Finland
Intermittent esotropy
24.6
9.6
13
6
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.4
9.4
21
47
SPAT1229
SPAT
Assessment of need for aid
11.2
9.2
17
18
JDB10
NOMESCO Finland
Percutaneous gastrostomy
27.0
9.2
12
5
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
13.4
8.9
15
13
R62.0
ICD-10 Finland
Delayed milestone
7.6
8.6
20
32
G41.9
ICD-10 Finland
Status epilepticus, unspecified
98.1
8.6
9
*
NAG53
NOMESCO Finland
Posterior or lateral fusion of thoracic spine with fixation, more than 3 vertebraea
98.1
8.6
9
*
N03AF03
ATC
rufinamide; oral
+∞
8.4
8
*
TJD20
NOMESCO Finland
Change of gastrostomy tube
36.7
8.2
10
*
N03AX18
ATC
lacosamide; systemic
20.4
7.8
11
6
R1260
NOMESCO Finland
Evaluation of communicative skills
20.4
7.8
11
6
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.3
7.7
23
65
3046, ,
Kela drug reimbursment
+∞
7.4
7
*
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
7.4
7.3
17
27
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
13.5
7.3
12
10
N03AX15
ATC
zonisamide; oral
32.7
7.3
9
*
G03DC03
ATC
lynestrenol; oral
32.7
7.3
9
*
R1240
NOMESCO Finland
Social assessment of need and possibilities of rehabilitation
32.7
7.3
9
*
F83
ICD-10 Finland
Mixed specific developmental disorders
8.6
7.2
15
20
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
18.3
6.9
10
6
R5140, ,
SPAT
43.2
6.9
8
*
RT490, ,
NOMESCO Finland
24.5
6.8
9
*
WYA20
NOMESCO Finland
Home visit
24.5
6.8
9
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.5
6.8
30
111
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.5
6.8
30
111
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.4
6.7
31
118
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
15.7
6.5
10
7
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
15.7
6.5
10
7
WX408
NOMESCO Finland
General anesthesy, balanced
3.1
6.5
41
187
7803A
ICD-9 Finland
General symptoms, Convulsions
74.5
6.5
7
*
ADB00
NOMESCO Finland
Implantation of vagus nerve stimulating device
74.5
6.5
7
*
Z3229
NOMESCO Finland
Other healthcare associate professional
4.0
6.4
21
63
WYA30, ,
SPAT
19.6
6.4
9
5
G40.00
ICD-10 Finland
Benign childhood epilepsy with centrotemporal EEG spikes
28.7
6.3
8
*
N03AX22
ATC
perampanel; oral
28.7
6.3
8
*
WKEHK, ,
NOMESCO Finland
+∞
6.3
6
*
N03AA02
ATC
phenobarbital; systemic
+∞
6.3
6
*
1530, ,
Kela drug reimbursment
+∞
6.3
6
*
199
Kela drug reimbursment
Rufinamide
+∞
6.3
6
*
R5130, ,
SPAT
+∞
6.3
6
*
Q02
ICD-10 Finland
Microcephaly
+∞
6.3
6
*
N03AE01
ATC
clonazepam; systemic
9.6
6.3
12
14
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.1
6.3
35
149
R1250
NOMESCO Finland
Evaluation of functional capability
11.1
6.2
11
11
ZXE10
NOMESCO Finland
More than one and less than three hours
2.9
6.1
44
216

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
40
158
3.59
8.39
3.7
2.9
—
—
—
0
0
42
178
3.38
7.80
4.9
4.5
—
—
—
0
0
15
27
6.36
5.97
6.7
6.0
23.47
24.56
mmol/l
0.59
15
27
10
14
7.81
4.78
2.9
2.7
17.88
16.21
%
—
10
14
11
19
6.37
4.59
3.0
2.9
92.92
91.09
%
0.58
11
19
59
376
2.43
4.37
4.2
3.8
0.00
0.00
estimate
-0.00
13
51
63
414
2.46
4.35
12.0
13.7
1.22
1.22
mmol/l
0.01
58
385
9
13
7.49
4.27
1.7
3.2
1.77
2.09
umol/l
—
9
13
9
13
7.49
4.27
2.9
2.0
1.72
1.42
mmol/l
—
9
13
58
370
2.39
4.25
4.2
3.8
0.00
0.00
estimate
-0.00
13
58
58
375
2.34
4.05
4.2
3.8
0.00
0.00
estimate
-0.00
13
56
24
104
2.73
3.99
8.8
19.0
106.25
104.33
mmol/l
1.00
24
104
34
181
2.35
3.67
4.9
3.8
0.00
0.00
estimate
-0.00
12
54
32
166
2.38
3.66
12.5
9.3
5.23
5.12
kpa
0.30
32
161
18
70
2.92
3.63
10.6
19.9
7.39
7.42
ph
—
9
38
45
273
2.20
3.53
3.4
4.1
97.50
33.25
e6/l
0.32
35
204
18
72
2.84
3.45
10.3
19.3
1.72
0.30
mmol/l
0.55
13
61
43
260
2.17
3.37
9.4
11.3
1.16
1.23
inr
0.58
36
219
0
82
0.00
3.33
0.0
1.2
—
6.33
—
0
71
0
81
0.00
3.32
0.0
1.2
—
1.32
—
0
65
42
256
2.12
3.19
4.5
3.2
0.00
0.00
estimate
-0.00
12
48
16
63
2.84
3.14
9.1
16.9
123.13
124.06
g/l
0.05
16
63
0
79
0.00
3.12
0.0
1.2
—
2.47
—
0
66
53
357
2.06
3.05
5.1
8.2
19.85
20.40
umol/l
0.02
43
340
5
5
10.43
3.01
2.6
1.8
51.29
45.60
umol/l
—
5
5
17
71
2.69
3.00
11.1
19.5
5.28
5.05
kpa
0.69
17
71
17
71
2.69
3.00
11.1
19.4
12.13
14.04
kpa
0.69
17
71
0
76
0.00
2.90
0.0
1.5
—
—
—
0
0
5
6
8.69
2.78
2.2
2.7
1.12
1.11
umol/l
—
5
6
27
145
2.19
2.78
9.0
9.2
—
—
—
0
0
48
322
1.96
2.70
4.6
5.2
64.16
74.95
e6/l
0.09
34
218
11
36
3.31
2.66
2.8
8.7
36.96
36.96
°c
0.01
11
36
6
11
5.73
2.58
5.0
3.5
—
—
—
0
0
66
500
1.98
2.54
5.5
4.1
—
—
—
0
0
34
207
1.98
2.49
3.5
4.3
—
—
—
0
0
31
183
2.02
2.48
4.9
13.8
7.36
7.37
ph
0.21
24
111
13
52
2.73
2.47
1.2
6.7
0.50
0.44
%
—
6
18
30
179
1.97
2.31
3.7
2.4
0.00
0.00
estimate
-0.00
11
48
13
54
2.62
2.31
1.9
6.9
0.00
0.00
%
—
5
18
9
30
3.20
2.21
1.6
4.4
32.89
40.50
umol/l
—
9
30
12
49
2.65
2.20
4.2
2.6
—
—
—
0
0
31
191
1.91
2.16
16.5
20.3
25.57
24.87
mmol/l
0.40
31
191
8
183
0.39
2.10
1.4
2.0
—
—
—
0
0
5
10
5.20
2.09
2.2
2.4
11.26
12.49
umol/l
—
5
10
18
93
2.15
2.01
2.0
1.8
—
—
—
0
0
28
171
1.89
1.99
10.0
14.9
—
—
—
0
0
0
50
0.00
1.95
0.0
1.1
—
5.30
—
0
39
66
525
1.79
1.91
5.7
7.0
125.10
112.65
u/l
0.52
60
491
13
60
2.35
1.87
2.0
6.3
0.50
0.71
%
—
6
24
37
251
1.76
1.87
3.2
4.0
0.77
0.28
e6/l
0.45
27
184
7
23
3.20
1.83
4.3
2.5
554.86
268.78
ug/l
—
7
23
0
47
0.00
1.76
0.0
1.9
—
—
—
0
0
0
47
0.00
1.76
0.0
1.1
—
8.11
—
0
35
0
47
0.00
1.76
0.0
1.1
—
0.35
—
0
30
26
162
1.82
1.72
3.0
4.0
2.08
1.51
e6/l
0.16
13
87
12
224
0.47
1.66
1.3
2.0
—
—
—
0
0
9
37
2.57
1.52
2.0
7.9
23.39
23.86
mmol/l
—
9
37
29
195
1.69
1.47
3.5
3.6
7.41
7.39
ph
1.23
21
130
9
39
2.44
1.47
19.1
30.3
25.11
23.82
mmol/l
—
9
39
27
179
1.70
1.44
4.7
3.5
1.02
1.02
kg/l
0.57
19
113
41
304
1.60
1.42
2.9
3.0
—
—
estimate
—
0
0
9
42
2.26
1.38
13.6
22.8
15.34
16.31
%
—
9
42
19
115
1.81
1.37
1.7
2.6
384.42
318.97
nmol/l
0.59
19
107
10
48
2.21
1.33
17.3
26.0
96.51
95.35
%
—
10
48
14
78
1.93
1.29
1.4
1.4
—
—
—
0
0
6
25
2.49
1.26
2.2
1.8
—
—
—
0
0
6
25
2.49
1.26
2.2
1.8
—
—
—
0
0
6
25
2.49
1.26
2.2
1.8
—
—
—
0
0
6
25
2.49
1.26
2.2
1.8
—
—
—
0
0
58
476
1.54
1.24
9.9
13.1
0.00
0.00
e9/l
0.80
53
374
34
248
1.57
1.24
3.1
3.9
—
—
estimate
—
0
0
17
107
1.71
1.08
1.5
1.6
—
—
—
0
0
10
53
1.99
1.05
4.5
23.5
0.57
0.61
%
—
10
53
9
49
1.92
1.02
19.1
25.4
0.82
1.24
%
—
9
49
10
54
1.95
1.01
4.5
23.1
0.89
1.32
%
—
10
54
0
28
0.00
0.99
0.0
2.0
—
7.95
—
0
6
0
28
0.00
0.99
0.0
1.1
—
—
—
0
0
0
32
0.00
0.97
0.0
1.2
—
—
—
0
0
0
32
0.00
0.97
0.0
1.2
—
—
—
0
0
14
87
1.71
0.93
1.6
1.8
606.44
435.68
pmol/l
—
9
80
85
780
1.68
0.93
17.1
10.4
—
—
—
0
0
8
139
0.54
0.92
1.1
1.7
—
—
—
0
0
40
320
1.42
0.89
3.4
3.6
6.37
6.27
ph
0.15
15
144
31
237
1.45
0.88
4.4
3.0
2.35
2.39
mmol/l
1.34
31
221
9
148
0.57
0.88
1.0
1.3
—
—
—
0
0
6
31
1.99
0.86
3.3
4.1
—
—
—
0
0
0
24
0.00
0.80
0.0
6.0
—
0.25
—
0
11
49
568
0.73
0.80
3.2
3.8
1.21
1.19
mmol/l
0.10
43
540
0
25
0.00
0.80
0.0
1.2
—
—
—
0
0
0
26
0.00
0.79
0.0
5.3
—
35.87
—
0
26
52
596
0.73
0.78
3.7
4.2
1.33
1.42
mmol/l
0.88
45
567
30
233
1.41
0.78
1.3
1.5
—
—
—
0
0
9
56
1.67
0.75
1.4
1.1
—
—
—
0
0
28
218
1.40
0.71
3.1
2.8
—
—
—
0
0
5
28
1.83
0.67
6.8
34.0
58.20
70.63
%
—
5
28
5
28
1.83
0.67
2.6
2.5
—
—
—
0
0
8
50
1.65
0.63
21.1
25.0
0.65
0.66
%
—
8
50
84
786
1.48
0.63
19.5
14.0
39.62
23.96
mg/l
2.39
72
579
0
20
0.00
0.61
0.0
1.4
—
1.26
—
0
15
0
20
0.00
0.61
0.0
1.4
—
—
—
0
0
0
20
0.00
0.61
0.0
1.5
—
—
—
0
0
38
318
1.32
0.61
6.0
7.7
—
—
—
0
0
15
107
1.47
0.59
1.3
5.7
69.51
66.24
e9/l
—
8
76
0
23
0.00
0.59
0.0
1.4
—
—
—
0
0
34
403
0.76
0.59
2.9
3.6
65.94
81.75
ug/l
0.48
29
386
55
609
0.78
0.54
4.0
4.6
2.42
2.64
mmol/l
1.27
48
579
17
221
0.72
0.54
2.2
2.7
—
—
—
0
0
6
40
1.53
0.52
3.8
5.7
—
—
—
0
0
0
15
0.00
0.41
0.0
44.7
—
163.80
—
0
15
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
8
111
0.70
0.40
1.1
1.5
—
—
—
0
0
55
502
1.22
0.38
5.4
10.6
0.03
0.04
e9/l
0.51
49
422
55
502
1.22
0.38
5.4
10.6
0.59
0.57
e9/l
0.31
49
425
42
376
1.20
0.35
5.3
11.4
—
—
—
0
0
56
601
0.84
0.32
3.4
4.4
4.23
4.45
mmol/l
1.06
50
574
56
599
0.85
0.29
4.1
3.9
6.13
5.68
mmol/l
0.73
51
561
26
227
1.20
0.27
1.7
1.9
93.83
94.51
pmol/l
0.03
13
118
20
171
1.21
0.26
4.5
5.5
—
—
—
0
0
18
153
1.22
0.24
4.1
3.3
34.89
110.73
mg/l
1.11
12
109
5
37
1.37
0.24
2.0
3.7
7.70
5.73
ug/l
—
5
23
57
602
0.87
0.22
3.8
4.0
14.92
14.69
pmol/l
0.24
51
567
55
518
1.14
0.22
5.4
11.3
0.18
0.23
e9/l
1.17
50
448
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
172.27
—
0
11
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
3.47
—
0
10
0
10
0.00
0.21
0.0
2.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
214.80
—
0
10
0
13
0.00
0.21
0.0
2.1
—
—
—
0
0
18
156
1.19
0.20
4.5
3.9
8.10
10.75
mg/mmol
0.24
12
107
0
14
0.00
0.20
0.0
4.1
—
0.52
—
0
14
51
480
1.13
0.20
5.5
10.7
0.53
0.68
%
1.00
51
457
52
490
1.13
0.20
5.2
10.5
51.91
51.64
%
0.05
52
476
51
482
1.12
0.18
5.5
10.6
2.64
3.40
%
1.74
51
457
22
198
1.14
0.16
3.2
3.8
22.58
42.54
ng/l
0.97
17
133
51
486
1.10
0.14
5.5
10.7
8.42
8.50
%
0.09
51
463
52
498
1.09
0.12
5.5
10.5
32.77
33.45
%
0.14
52
481
10
116
0.85
0.12
1.0
1.2
—
—
—
0
0
5
47
1.07
0.09
1.8
2.3
—
—
—
0
0
6
53
1.14
0.09
1.0
1.5
—
—
—
0
0
5
61
0.81
0.08
1.2
1.5
—
—
—
0
0
8
91
0.87
0.07
3.5
2.7
5.51
4.27
e9/l
—
8
80
21
198
1.08
0.06
3.0
1.7
—
—
—
0
0
34
332
1.04
0.02
1.3
1.8
0.36
2.68
u/ml
—
7
57
15
156
0.95
0.00
2.5
2.9
—
—
—
0
0
31
312
0.99
0.00
1.5
1.9
1.60
1.78
g/l
0.41
21
153
68
685
0.98
0.00
4.1
4.6
1.67
1.98
mu/l
2.26
62
648
0
8
0.00
0.00
0.0
1.8
—
19.96
—
0
8
0
8
0.00
0.00
0.0
2.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
22.3
—
8.94
—
0
8
8
89
0.89
0.00
1.3
1.4
66.50
213.60
u/ml
—
8
83
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
7
78
0.89
-0.00
1.1
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
7.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
32.7
—
0.55
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
27.80
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
23.98
—
0
9
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
223.83
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
3.73
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
1430.71
—
0
7
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint F5_SEVRET and mortality.

Females

Parameter HR [95% CI] p-value
F5_SEVRET 7.236 [4.69, 11.16] < 0.001
Birth year 0.996 [0.99, 1.0] 0.367

During the follow-up period (1.1.1998 — 31.12.2019), 263 out of 981 females with F5_SEVRET died.

Males

Parameter HR [95% CI] p-value
F5_SEVRET 5.907 [4.34, 8.03] < 0.001
Birth year 0.992 [0.98, 1.0] 0.091

During the follow-up period (1.1.1998 — 31.12.2019), 324 out of 1391 males with F5_SEVRET died.

Mortality risk

Mortality risk for people of age

years, who have F5_SEVRET.

N-year risk Females Males
1 0.712% 1.176%
5 4.535% 7.074%
10 9.503% 17.82%
15 18.507% 31.6%
20 31.77% 46.652%

Relationships between endpoints

Index endpoint: F5_SEVRET – Severe mental retardation

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data