autoimmune thrombocytopenic purpura: An autoimmune disorder in which the number of circulating platelets is reduced due to their antibody-mediated destruction. ITP is a diagnosis of exclusion and is heterogeneous in origin.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1336 |
4. Check minimum number of eventsNone |
1336 |
5. Include endpointsNone |
1336 |
6. Filter based on genotype QC (FinnGen only) |
1159 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D69
- Name in latin
- Purpura idiopathica thrombocytopenica
Similar endpoints
↥List of similar endpoints to
Idiopathic thrombocytopenic purpura
based on the number of shared cases.
Similar with more cases:
- Purpura and other haemorrhagic conditions
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9562 | 4823 | 4657 |
| Only index persons | 8094 | 4155 | 3939 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.14 | 0.13 |
| Only index persons | 0.15 | 0.15 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 50.61 | 48.79 | 52.21 |
| Only index persons | 47.50 | 45.05 | 50.09 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1159 | 610 | 549 |
| Unadjusted period prevalence (%) | 0.23 | 0.22 | 0.25 |
| Median age at first event (years) | 52.55 | 44.85 | 61.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1204
- Matched controls
- 12040
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
XW000
NOMESCO Finland
Bone marrow biopsy
22.3
307.7
333
203
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
+∞
307.7
1086
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
1001.1
307.7
648
14
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
+∞
276.0
254
*
2873A
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[PURPURA THROMBOCYTOPENICA IDIOPATHICA (ITP)]
+∞
136.1
128
*
H02AB06
ATC
prednisolone; systemic
4.2
121.3
825
4111
B02BX05
ATC
eltrombopag; oral
+∞
106.9
101
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.4
106.2
340
991
WW500
NOMESCO Finland
Blood transfusion
7.7
98.1
147
214
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
34.6
83.2
53
16
3039, ,
Kela drug reimbursment
+∞
82.2
78
*
1517, ,
Kela drug reimbursment
+∞
82.2
78
*
ZX120
NOMESCO Finland
Intravenous
4.3
73.8
217
582
D69.4
ICD-10 Finland
Other primary thrombocytopenia
+∞
72.6
69
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.9
70.8
538
2605
JMA10
NOMESCO Finland
Transabdominal total splenectomy
27.7
70.3
48
18
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
30.4
66.4
44
15
H02AB07
ATC
prednisone; oral
3.5
64.7
265
890
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
335.3
63.0
63
*
L04AX01
ATC
azathioprine; systemic
5.8
59.6
115
215
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.8
57.3
197
586
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
87.1
52.4
58
7
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
15.7
47.0
41
27
D70.89
ICD-10 Finland
Neutropenic splenomegaly
11.6
46.9
49
44
6BA02, ,
NOMESCO Finland
99.9
44.1
48
5
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
4.7
43.0
104
236
D69.5
ICD-10 Finland
Secondary thrombocytopenia
421.5
41.4
41
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
40.2
668
4313
1XC02, ,
NOMESCO Finland
14.4
38.3
35
25
3052, ,
Kela drug reimbursment
+∞
37.7
36
*
1524, ,
Kela drug reimbursment
+∞
37.7
36
*
28710
ICD-8 Finland
Purpura and other haemorrhagic conditions, Thrombocytopenia essentialis (Morbus Werlhof)
+∞
36.6
35
*
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
10.1
35.8
41
42
3038, ,
Kela drug reimbursment
+∞
35.6
34
*
B02BX04
ATC
romiplostim; parenteral
+∞
35.6
34
*
1516, ,
Kela drug reimbursment
+∞
35.6
34
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
5.9
35.2
65
116
D69.1
ICD-10 Finland
Qualitative platelet defects
357.2
35.1
35
*
L04AD01
ATC
ciclosporin; systemic
7.1
34.6
53
78
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
8.3
33.9
45
56
6753
FHL
Transabdominal splenectomy
123.6
33.9
36
*
B02BX08
ATC
avatrombopag; systemic
+∞
33.5
32
*
R50.9
ICD-10 Finland
Fever, unspecified
2.4
31.6
253
1185
B02AA02
ATC
tranexamic acid; systemic
2.6
30.4
205
884
28719
ICD-8 Finland
Purpura and other haemorrhagic conditions, Thrombocytopenia NUD
+∞
29.3
28
*
A02BC02
ATC
pantoprazole; systemic
2.1
28.6
845
6408
D68.8
ICD-10 Finland
Other specified coagulation defects
36.0
27.5
35
10
L04AA06
ATC
mycophenolic acid; systemic
6.1
27.1
48
82
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
26.1
387
2295
H02AB02
ATC
dexamethasone; systemic
2.6
26.0
171
726
H02AB09
ATC
hydrocortisone; systemic
5.0
25.9
57
119
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
24.7
25.8
36
15
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.5
25.1
175
763
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
8.2
24.8
33
41
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.1
23.4
106
369
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
23.3
368
2216
J01MA12
ATC
levofloxacin; systemic
2.1
22.8
254
1349
D69.0
ICD-10 Finland
Allergic purpura
53.1
22.1
26
5
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
6.4
21.5
36
58
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.4
21.1
78
240
R04.0
ICD-10 Finland
Epistaxis
2.7
21.0
123
492
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
20.9
295
1700
P01BA02
ATC
hydroxychloroquine; oral
2.7
20.5
119
473
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.5
20.0
134
572
A02BC01
ATC
omeprazole; systemic
1.9
19.8
349
2159
M04AA01
ATC
allopurinol; systemic
2.2
19.8
183
899
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
5.8
19.5
36
64
M05BA04
ATC
alendronic acid; oral
2.5
18.9
123
517
D64.9
ICD-10 Finland
Anaemia, unspecified
2.3
18.9
157
737
120
Kela drug reimbursment
Hypogammaglobulinaemia
101.7
18.6
20
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
39.1
18.6
23
6
R23.3
ICD-10 Finland
Spontaneous ecchymoses
4.6
17.9
43
97
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
96.5
17.6
19
*
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
7.9
17.5
24
31
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
7.2
17.4
26
37
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.3
17.3
150
716
TGC00
NOMESCO Finland
Bronchial lavation
3.9
17.0
51
136
R59.9
ICD-10 Finland
Enlarged lymph nodes, unspecified
5.9
16.7
30
52
ZX112
NOMESCO Finland
Subcutaneous
4.2
16.6
44
107
B01AB05
ATC
enoxaparin; parenteral
1.7
16.6
374
2470
A46
ICD-10 Finland
Erysipelas
2.0
16.3
191
1023
C03CA01
ATC
furosemide; systemic
1.7
16.3
377
2505
WZC00
NOMESCO Finland
Treatment plan or consultation
1.7
15.8
451
3165
D47.3
ICD-10 Finland
Essential (haemorrhagic) thrombocythaemia
7.3
15.7
23
32
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.3
15.5
120
546
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.8
14.9
78
294
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
14.6
14
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
14.4
231
1372
J01MA14
ATC
moxifloxacin; systemic
2.3
14.4
117
543
JN3AD
NOMESCO Finland
Abdominal CT examination
2.0
14.3
167
891
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
3.9
14.1
41
107
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
10.2
14.0
27
27
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
3.3
13.8
53
167
JN4BD
NOMESCO Finland
Extensive body CT
2.1
13.7
134
670
PJA10
NOMESCO Finland
Exploration of lymph nodes
5.2
13.7
28
55
D68.9
ICD-10 Finland
Coagulation defect, unspecified
76.0
13.6
15
*
J05AB01
ATC
aciclovir; systemic
1.8
13.6
266
1675
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
13.6
272
1724
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.5
13.5
91
388
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
10.2
13.5
26
26
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.6
13.3
78
311
B01AA03
ATC
warfarin; systemic
1.8
13.2
227
1374
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
40.5
13.2
16
*
L03AA02
ATC
filgrastim; parenteral
3.5
13.0
45
133
UJF32
NOMESCO Finland
Coloscopy
1.7
12.5
300
1991
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.8
12.3
207
1242
R79.8
ICD-10 Finland
Other specified abnormal findings of blood chemistry
9.8
12.3
24
25
JN4AD
NOMESCO Finland
Body CT examination
2.0
12.2
147
793
A03
ICPC
Fever
1.8
12.1
221
1359
WW200
NOMESCO Finland
Immunization
3.3
11.9
44
136
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.5
11.8
74
305
J01DB01
ATC
cefalexin; oral
1.7
11.8
965
8482
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
16.6
11.7
18
11
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.0
11.7
142
768
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
65.6
11.6
13
*
WZC30
NOMESCO Finland
Teaching
1.8
11.5
196
1179
ZXD05
NOMESCO Finland
Urgent procedure
1.6
11.5
353
2482
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
5.1
11.5
24
48
D61.3
ICD-10 Finland
Idiopathic aplastic anaemia
+∞
11.5
11
*
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
4.9
11.5
25
52
B99
ICPC
Blood/lymph/spleen disease other
11.9
11.3
20
17
J01FF01
ATC
clindamycin; systemic
1.6
11.3
306
2088
D69.2
ICD-10 Finland
Other nonthrombocytopenic purpura
35.4
11.3
14
*
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
43.7
10.9
13
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
10.9
297
2027
A41.9
ICD-10 Finland
Sepsis, unspecified
2.8
10.9
54
198
D07AB08
ATC
desonide; topical
1.9
10.8
135
736
R06
ICPC
Nose bleed/epistaxis
3.3
10.7
40
124
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
4.6
10.7
25
55
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.7
10.7
244
1592
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
10.6
157
906
R79.9
ICD-10 Finland
Abnormal finding of blood chemistry, unspecified
9.3
10.5
21
23
A10AB05
ATC
insulin aspart; parenteral
2.1
10.5
102
508
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
4.7
10.5
24
52
2875A
ICD-9 Finland
Purpura and other haemorrhagic conditions, Thrombocytopenia, unspecified
+∞
10.4
10
*
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
5.5
10.4
20
37
D61.9
ICD-10 Finland
Aplastic anaemia, unspecified
32.8
10.3
13
*
A05AA02
ATC
ursodeoxycholic acid; oral
4.1
10.3
28
70
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.9
10.2
139
780
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
3.5
10.2
35
103
L04AA01
ATC
[U] ciclosporin
5.1
10.1
21
42
UJF30
NOMESCO Finland
Ileoscopy through colon
1.9
9.9
122
663
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.3
9.8
78
359
E0000UV, ,
ATC
1.5
9.7
474
3659
D46.7
ICD-10 Finland
Other myelodysplastic syndromes
13.5
9.7
16
12
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
55.4
9.7
11
*
122
Kela drug reimbursment
Aplastic anaemia
55.4
9.7
11
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.1
9.5
96
485
D73.0
ICD-10 Finland
Hyposplenism
100.8
9.4
10
*
C81.0
ICD-10 Finland
Nodular lymphocyte predominant Hodgkin lymphoma
100.8
9.4
10
*
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
100.8
9.4
10
*
TPH07
NOMESCO Finland
Cathetrisation of artery
1.8
9.4
137
785
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
9.4
597
4845
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.0
9.4
112
601
B83
ICPC
Purpura/coagulation defect
+∞
9.4
9
*
M10.9
ICD-10 Finland
Gout, unspecified
2.1
9.3
90
447
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.1
9.2
90
449
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.6
9.1
30
86
K83.0
ICD-10 Finland
Cholangitis
4.0
9.1
25
63
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
10.1
9.0
17
17
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.2
9.0
79
378
J01CA04
ATC
amoxicillin; systemic
1.6
9.0
954
8534
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
24.2
8.9
12
5
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
24.2
8.9
12
5
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
8.9
406
3082
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.2
8.8
75
355
C03DA01
ATC
spironolactone; oral
1.8
8.8
148
886
ZXE00
NOMESCO Finland
One hour or less
1.5
8.8
428
3290
J01MA02
ATC
ciprofloxacin; systemic
1.5
8.7
422
3236
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
2.7
8.7
45
169
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.9
8.7
121
684
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
7.7
8.7
19
25
C90.0
ICD-10 Finland
Multiple myeloma
4.6
8.6
20
44
I82.9
ICD-10 Finland
Embolism and thrombosis of unspecified vein
3.7
8.6
27
75
M35.1
ICD-10 Finland
Other overlap syndromes
11.7
8.6
15
13
J01AA02
ATC
doxycycline; systemic
1.5
8.5
843
7381
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
12.9
8.4
14
11
D62
ICD-10 Finland
Acute posthaemorrhagic anaemia
4.7
8.4
19
41
2873X
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[THROMBOCYTOPENIA PRIMARIA NUD]
+∞
8.3
8
*
D61.0
ICD-10 Finland
Constitutional aplastic anaemia
+∞
8.3
8
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
8.3
219
1474
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
8.2
467
3682
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
4.0
8.2
23
59
A10AC01
ATC
insulin (human); parenteral
2.0
8.2
95
506
Z3231
NOMESCO Finland
Registered nurse
1.5
8.1
302
2192
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
8.1
224
1523
AA1AD
NOMESCO Finland
CT of head and brain
1.5
8.1
321
2361
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
11.8
8.1
14
12
ZX108
NOMESCO Finland
Inhalation
6.9
8.1
19
28
E66.8
ICD-10 Finland
Other obesity
2.2
8.0
64
296
M01AE01
ATC
ibuprofen; systemic, rectal
0.7
7.9
852
9394
A04AA01
ATC
ondansetron; systemic, rectal
1.9
7.9
94
504
A04.8
ICD-10 Finland
Other specified bacterial intestinal infections
3.6
7.9
25
70
PJ2AT
NOMESCO Finland
Biopsy of lymphnode with ultrasound guidance
7.0
7.8
18
26
D68.3
ICD-10 Finland
Haemorrhagic disorder due to circulating anticoagulants
45.3
7.7
9
*
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.5
7.7
321
2382
N05CF01
ATC
zopiclone; oral
1.5
7.6
338
2540
B01AB10
ATC
tinzaparin; parenteral
1.8
7.5
124
737
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
13.5
7.4
12
9
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.1
7.4
71
353
127
Kela drug reimbursment
Transplant complication
3.6
7.3
23
64
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
7.3
460
3674
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.8
7.3
103
584
SPAT1255
SPAT
Intravenous administration of medicine
2.0
7.3
77
396
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
7.3
264
1901
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
9.4
7.3
14
15
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
3.0
7.3
31
105
N02BE01
ATC
paracetamol; systemic, rectal
1.6
7.2
1018
9361
9989/3-C42.1
ICD-O-3
Myelodysplastic syndrome, NOS, of bone marrow
15.8
7.2
11
7
N02AX02
ATC
tramadol; systemic, rectal
1.4
7.2
458
3661
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
4.3
7.2
18
42
Z31.5
ICD-10 Finland
Genetic counselling
2.2
7.2
62
295
NK1XE
NOMESCO Finland
Other ultrasound examinnation of muscle or tendon
4.5
7.2
17
38
R05
ICD-10 Finland
Cough
1.5
7.2
235
1658
N02AA05
ATC
oxycodone; systemic
1.6
7.1
200
1362
K29
ICPC
Cardiovascular sympt/complt other
2.3
7.1
52
231
B03BA03
ATC
hydroxocobalamin; parenteral
2.1
7.1
64
310
Z2221
NOMESCO Finland
Medical doctor
1.5
7.1
294
2172
B28
ICPC
Limited function/disability (B)
8.8
7.1
14
16
K92.1
ICD-10 Finland
Melaena
2.1
7.1
66
325
K76.9
ICD-10 Finland
Liver disease, unspecified
4.2
7.0
18
43
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.8
7.0
34
124
I80.1
ICD-10 Finland
Phlebitis and thrombophlebitis of femoral vein
3.3
7.0
25
76
A02BC03
ATC
lansoprazole; oral
1.5
7.0
294
2181
B03XA02
ATC
darbepoetin alfa; parenteral
3.0
7.0
29
97
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
6.9
432
3439
XF600
NOMESCO Finland
Bloodpressure measurement
2.0
6.9
77
405
JN6AD
NOMESCO Finland
CT of torso and neck
3.4
6.9
24
72
B01AB04
ATC
dalteparin; parenteral
2.2
6.8
55
255
K74.3
ICD-10 Finland
Primary biliary cirrhosis
8.3
6.8
14
17
D86.0
ICD-10 Finland
Sarcoidosis of lung
4.1
6.8
18
44
L01AA01
ATC
cyclophosphamide; systemic
9.4
6.8
13
14
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
9.4
6.8
13
14
PJD42
NOMESCO Finland
Excision of axillary lymph nodes
5.7
6.8
18
32
H03AA01
ATC
levothyroxine sodium; systemic
1.5
6.8
235
1676
D07AC01
ATC
betamethasone; topical
1.4
6.8
383
2996
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
6.7
375
2924
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
1.8
6.7
104
607
H26.3
ICD-10 Finland
Drug-induced cataract
7.2
6.7
15
21
H02AB04
ATC
methylprednisolone; systemic
1.6
6.7
150
968
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.0
6.6
75
396
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.1
6.6
60
292
ZX114
NOMESCO Finland
Intramuscular
3.6
6.6
21
59
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
12.3
6.6
11
9
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
2.5
6.6
39
158
318
Kela drug reimbursment
Teriparatide
8.7
6.6
13
15
J47
ICD-10 Finland
Bronchiectasis
3.0
6.5
27
90
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
6.9
6.5
15
22
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
2.6
6.5
36
141
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.5
6.4
264
1946
M10.0
ICD-10 Finland
Idiopathic gout
2.4
6.4
44
191
TK800
NOMESCO Finland
Hemodialysis
2.9
6.4
29
102
B99
ICD-10 Finland
Other and unspecified infectious diseases
2.9
6.4
29
102
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.7
6.4
132
836
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.5
6.3
196
1364
QDA10
NOMESCO Finland
Incision of skin of lower limb
6.0
6.3
16
27
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.6
6.3
158
1048
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.2
6.3
50
231
H05AA02
ATC
teriparatide; parenteral
9.3
6.3
12
13
ZXE20
NOMESCO Finland
More than three and less than five hours
1.6
6.3
144
935
C08CA05
ATC
nifedipine; systemic
2.0
6.3
69
361
D69.8
ICD-10 Finland
Other specified haemorrhagic conditions
18.1
6.3
9
5
D89.89
ICD-10 Finland
Other specified disorders involving the immune mechanism, not elsewhere classified
+∞
6.3
6
*
WE300
NOMESCO Finland
Profylactive therapy of malignancy with biomoidiers
+∞
6.3
6
*
D73.1
ICD-10 Finland
Hypersplenism
26.8
6.2
8
*
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
6.2
555
4659
UJF92
NOMESCO Finland
Capsular endoscopy
2.8
6.2
29
104
XF400
NOMESCO Finland
ECG with 12 standard connections
1.6
6.1
165
1113
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.3
6.1
43
189
TQW99
NOMESCO Finland
Other minor procedure on skin
2.1
6.1
59
295
M81.4
ICD-10 Finland
Drug-induced osteoporosis
8.6
6.1
12
14
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
3.3
6.0
22
68
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
258
156
20.78
318.37
1.5
1.4
—
—
—
0
0
560
1210
7.78
273.87
8.1
4.0
255.15
254.34
u/l
0.02
548
1154
547
1241
7.24
252.08
6.1
2.5
2.04
1.77
%
5.37
510
1129
469
963
7.34
237.09
5.7
2.4
82.90
69.03
e9/l
7.85
358
731
424
841
7.24
220.15
4.9
2.8
10.67
10.72
g/l
0.06
404
780
245
253
11.90
219.20
3.0
1.6
—
—
—
0
0
355
670
7.10
191.30
2.5
1.7
1.30
1.46
g/l
0.46
331
622
208
318
7.70
134.13
2.9
3.1
3.27
3.64
g/l
2.41
200
309
92
51
19.45
115.92
4.0
1.8
—
—
—
0
0
92
51
19.45
115.92
4.0
1.8
—
—
—
0
0
231
478
5.74
109.40
2.9
1.9
1.14
1.54
g/l
7.76
199
428
150
224
7.51
97.87
6.6
5.6
683.65
337.33
iu/ml
0.53
26
30
431
1624
3.58
91.27
2.8
2.3
29.43
29.53
s
0.10
417
1574
121
153
8.68
90.88
1.4
1.2
3.69
3.84
u/ml
0.02
64
50
123
175
7.71
83.50
3.2
3.7
786.63
2329.18
u/ml
—
8
11
279
860
3.92
78.63
3.5
2.7
66.33
66.49
g/l
0.11
265
792
171
367
5.27
76.63
1.7
1.6
21.94
9.55
u/ml
1.79
23
77
940
6025
3.55
76.03
22.7
9.2
3.98
4.16
e9/l
1.60
887
5220
151
299
5.63
73.95
3.3
2.7
190.76
190.09
%
0.03
145
287
73
62
12.47
72.68
3.0
2.4
—
—
—
0
0
489
2259
2.96
70.08
2.5
1.4
2.42
2.37
g/l
0.16
392
1387
153
337
5.06
66.23
4.1
1.5
0.20
0.24
g/l
5.15
143
321
119
209
6.21
65.94
1.3
1.6
136.13
142.00
au/ml
0.15
32
62
154
347
4.94
64.86
4.0
1.5
1.11
1.19
g/l
2.27
146
332
100
154
6.99
62.90
1.5
1.2
4.73
3.73
u/ml
0.36
59
67
120
227
5.76
61.47
1.3
1.4
327.28
263.69
u/ml
0.54
69
127
164
411
4.46
60.41
2.4
2.4
3.39
3.71
g/l
1.71
155
375
164
412
4.45
60.22
2.4
2.4
4.16
4.19
g/l
0.17
155
375
164
412
4.45
60.22
2.4
2.4
6.79
7.48
g/l
5.54
155
375
168
434
4.34
59.46
4.4
1.8
17.89
7.95
iu/ml
2.28
54
105
67
71
9.93
57.32
3.3
2.3
194.43
217.76
e6/l
0.25
53
59
65
69
9.90
55.52
3.2
2.2
565.30
603.98
e6/l
0.09
50
54
154
393
4.35
55.25
2.5
2.4
2.70
3.04
g/l
4.10
145
356
831
5445
2.70
55.07
12.7
6.4
12.58
12.12
umol/l
0.37
814
5194
92
161
6.10
50.96
6.1
3.7
0.82
1.39
%
0.90
84
148
490
2586
2.51
50.28
7.0
4.3
88.74
88.69
%
0.01
477
2533
389
1844
2.64
49.98
3.6
2.6
13.20
13.05
umol/l
0.16
378
1721
84
138
6.47
49.53
4.1
1.6
33.07
32.54
pg
0.51
84
138
367
1719
2.63
48.03
3.4
2.6
2.38
2.32
g/l
1.39
353
1600
348
1594
2.66
47.60
3.5
2.6
22.71
22.52
%
0.08
335
1495
133
358
4.05
44.15
2.6
2.6
0.98
1.24
g/l
0.33
116
316
132
355
4.05
43.86
2.5
2.4
11.03
10.63
g/l
0.31
122
316
784
5301
2.37
43.62
11.4
7.5
1.21
1.21
mmol/l
0.82
684
4579
50
52
9.99
43.25
1.2
1.2
—
—
—
0
0
477
2630
2.35
42.84
4.7
2.8
341.69
345.93
umol/l
0.38
446
2321
129
349
4.02
42.49
4.0
3.5
45.87
67.12
mg/l
0.63
111
302
129
349
4.02
42.49
4.0
3.5
38.54
49.76
mg/l
0.56
111
303
360
1773
2.47
41.50
5.0
3.6
0.81
0.82
mmol/l
0.66
347
1678
138
400
3.77
41.19
1.5
1.2
1.29
1.21
u/ml
—
7
26
720
4764
2.27
41.15
10.6
6.9
1.21
1.21
mmol/l
0.80
679
4408
118
311
4.10
40.23
3.9
3.4
2.50
2.43
ratio
0.04
72
186
503
2920
2.24
39.11
3.2
2.3
3.13
2.84
mg/l
1.46
461
2506
47
52
9.37
38.82
5.7
2.3
1213.87
1162.00
u/ml
0.04
47
52
709
4745
2.20
38.26
26.7
11.0
0.01
0.00
e9/l
1.39
616
3865
692
4588
2.20
38.23
8.7
5.2
34.97
35.66
g/l
2.46
667
4315
129
378
3.70
37.81
1.2
1.4
—
—
—
0
0
514
3044
2.20
37.68
2.0
1.7
18.53
20.18
nmol/l
1.97
476
2579
48
57
8.73
37.55
1.3
1.1
1.08
1.06
ratio
0.13
37
49
114
308
3.98
37.52
2.7
2.5
0.07
0.02
g/l
0.45
106
280
96
229
4.47
37.26
1.6
1.2
1.72
6.69
u/ml
—
9
15
702
4768
2.13
35.33
19.9
15.0
1.29
1.26
inr
0.69
605
3998
111
307
3.88
35.32
1.7
1.2
10.63
15.98
u/ml
—
7
12
300
1465
2.40
34.40
8.5
6.4
1.05
1.06
mmol/l
0.07
282
1371
988
7771
2.51
33.58
17.4
8.0
83.46
80.65
u/l
0.89
967
7371
105
290
3.87
33.44
1.7
1.2
3.28
2.72
u/ml
0.22
18
30
105
292
3.84
33.11
1.8
1.2
12.13
8.82
u/ml
0.15
30
44
61
109
5.84
32.95
5.6
3.8
49.05
56.48
%
1.51
53
99
670
4554
2.06
32.63
2.6
2.1
95.88
95.55
pmol/l
0.06
429
2422
91
233
4.14
32.16
1.6
1.2
40.48
43.83
u/ml
0.08
28
21
105
302
3.71
31.52
2.8
2.5
0.00
0.00
g/l
-0.00
94
265
233
1069
2.46
30.32
2.7
2.1
365.60
379.99
nmol/l
0.31
221
1003
62
122
5.30
30.19
1.5
1.3
68.20
84.26
u/ml
—
6
7
224
1012
2.49
30.12
3.9
2.4
0.20
0.21
g/l
0.96
217
946
402
2325
2.09
29.78
2.5
1.8
1.76
1.28
mg/l
0.91
332
1802
52
94
5.74
27.74
1.5
1.6
—
—
—
0
0
49
86
5.90
26.95
1.3
1.2
—
—
—
0
0
331
1847
2.09
26.48
2.5
1.9
—
—
—
0
0
942
7548
2.14
25.95
7.9
4.3
14.04
12.03
mm/h
3.08
912
7031
46
79
6.01
25.86
1.3
1.2
—
—
—
0
0
46
79
6.01
25.86
1.3
1.2
—
—
—
0
0
707
5159
1.90
25.25
4.7
3.2
174.11
116.86
ug/l
2.08
684
4811
426
2638
1.95
25.22
4.0
2.4
—
—
—
0
0
49
93
5.45
24.81
1.3
1.2
—
—
—
0
0
45
79
5.88
24.74
1.3
1.5
78.59
79.67
—
8
6
44
78
5.82
23.94
1.3
1.2
—
—
—
0
0
71
190
3.91
23.58
1.3
1.2
87.55
35.06
u/l
0.98
66
163
94
304
3.27
23.47
1.8
1.5
—
—
—
0
0
34
47
7.42
23.40
5.1
3.3
1.22
0.89
%
0.54
34
47
34
47
7.42
23.40
1.4
1.1
76.67
11.00
u/ml
—
6
7
807
6227
1.90
23.34
8.4
5.3
6.74
6.67
mmol/l
0.33
783
5881
95
314
3.20
22.88
1.9
1.6
—
—
—
0
0
43
78
5.68
22.85
1.3
1.2
—
—
—
0
0
305
1751
1.99
22.01
2.0
1.7
1223.88
1180.13
nmol/l
0.27
251
1334
231
1211
2.12
21.29
5.5
3.0
10.81
7.59
umol/l
0.87
212
1064
668
4965
1.78
20.68
4.4
2.8
—
—
estimate
—
0
0
83
270
3.23
20.51
1.7
1.4
—
—
—
0
0
114
445
2.73
20.36
3.1
2.0
44.80
39.06
u/l
1.25
104
398
508
3500
1.78
20.34
4.4
3.4
130.47
92.28
e6/l
0.28
415
2677
54
132
4.24
20.26
2.4
2.5
20.87
27.77
iu/ml
0.25
12
12
564
4012
1.76
20.16
5.3
4.0
82.97
113.16
e6/l
0.44
429
2808
194
969
2.19
20.16
11.1
7.8
9.91
9.76
mmol/l
0.10
185
935
451
3018
1.79
19.81
4.2
3.3
0.29
0.45
e6/l
1.80
358
2218
32
50
6.55
19.71
1.3
1.1
—
—
—
0
0
103
393
2.77
19.20
2.9
2.8
—
—
—
0
0
43
94
4.71
18.55
1.2
1.1
356.00
103.08
titre
—
5
13
70
221
3.30
18.16
1.7
1.4
—
—
—
0
0
375
2432
1.79
17.96
3.6
2.7
4.78
5.90
e6/l
1.24
353
2207
622
4643
1.70
17.96
3.3
2.5
74.65
76.21
nmol/l
0.75
579
4203
59
168
3.64
17.93
1.2
1.1
—
1.45
—
0
8
243
1398
1.92
16.95
2.3
1.8
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
89
336
2.78
16.92
3.6
4.4
0.32
0.37
iu/ml
0.90
57
185
34
67
5.19
16.53
2.7
2.6
37.93
42.29
%
0.59
22
34
231
1324
1.92
16.24
2.4
1.9
—
—
—
0
0
64
206
3.23
16.10
1.9
1.7
—
—
—
0
0
51
142
3.71
16.03
1.4
1.2
4.40
23.80
u/ml
—
5
5
151
758
2.13
15.31
2.1
1.7
—
—
—
0
0
41
101
4.17
15.25
1.9
1.6
—
—
—
0
0
41
101
4.17
15.25
1.9
1.6
—
—
—
0
0
41
101
4.17
15.25
1.9
1.6
—
—
—
0
0
36
81
4.55
15.02
2.4
1.5
—
—
—
0
0
102
451
2.38
14.01
2.1
1.8
0.95
1.97
ug/l
0.80
93
403
65
230
2.93
13.93
1.5
1.4
—
—
—
0
0
30
62
4.94
13.84
1.7
1.2
—
—
—
0
0
50
153
3.37
13.66
1.7
1.6
—
—
—
0
0
64
230
2.88
13.34
1.8
1.5
—
—
—
0
0
826
6905
1.63
13.27
5.8
4.7
91.21
1378.12
e6/l
1.40
14
103
85
355
2.50
13.21
1.6
1.5
0.24
0.08
iu/ml
0.52
24
56
474
3488
1.59
13.13
6.1
3.4
44.04
32.86
u/l
0.83
454
3310
693
5591
1.56
12.66
5.0
3.9
0.00
0.00
estimate
0.50
176
1205
16
5
32.40
12.58
1.3
1.4
—
—
—
0
0
40
112
3.66
12.50
1.5
1.2
—
—
—
0
0
447
3279
1.58
12.36
3.6
2.6
58.06
84.89
u/l
0.56
424
3049
22
38
5.88
12.29
1.5
1.3
—
—
—
0
0
152
829
1.95
12.20
5.1
3.4
1.22
1.22
mmol/l
0.62
136
710
432
3159
1.57
12.04
4.0
3.3
1431.69
1389.09
ng/l
0.09
383
2724
25
50
5.08
11.97
2.0
1.8
—
—
—
0
0
25
50
5.08
11.97
2.0
1.8
—
—
—
0
0
25
50
5.08
11.97
2.0
1.8
—
—
—
0
0
25
50
5.08
11.97
2.0
1.8
—
—
—
0
0
695
5659
1.54
11.81
5.1
3.9
0.00
5.24
estimate
1.33
181
1224
35
93
3.85
11.79
1.0
1.0
—
—
—
0
0
88
399
2.30
11.41
2.8
1.9
—
—
—
0
0
78
337
2.41
11.28
1.6
1.3
—
—
—
0
0
476
3599
1.53
11.22
4.2
3.4
2.34
2.35
mmol/l
2.31
445
3275
52
185
2.89
11.07
1.5
1.4
—
—
—
0
0
20
18
11.28
11.06
1.3
1.2
—
—
—
0
0
692
5681
1.51
10.93
5.1
3.9
0.04
0.28
estimate
0.44
166
1151
190
1160
1.76
10.59
6.1
4.2
1.37
1.71
mmol/l
0.53
172
977
316
2202
1.59
10.59
1.9
1.7
471.07
36581817.60
pmol/l
2.36
269
1837
71
303
2.43
10.56
1.5
1.3
—
—
—
0
0
22
27
8.28
10.34
1.3
1.1
72.85
93.67
%
1.19
13
15
22
27
8.28
10.34
1.4
1.0
74.23
90.13
%
1.09
13
15
45
154
3.00
10.27
1.7
1.5
—
—
—
0
0
23
49
4.77
10.26
4.8
1.9
1.96
1.93
umol/l
0.04
23
43
1090
10037
1.91
9.89
34.9
15.9
21.06
24.61
mg/l
3.77
983
8290
15
9
16.86
9.88
1.2
1.1
—
—
—
0
0
178
1089
1.74
9.82
3.9
3.3
—
—
—
0
0
70
310
2.34
9.61
1.5
1.6
—
—
—
0
0
42
144
2.99
9.57
1.1
1.1
—
—
—
0
0
19
21
9.17
9.53
1.2
1.2
—
—
—
0
0
275
1899
1.58
9.45
1.4
1.3
28.13
31.14
iu/ml
0.20
73
559
35
109
3.28
9.36
2.1
1.9
—
—
—
0
0
78
366
2.21
9.35
2.4
1.8
—
—
—
0
0
272
1883
1.57
9.22
3.5
3.0
1.32
1.06
e6/l
0.39
159
1021
23
54
4.32
9.14
3.2
7.7
—
46.14
—
0
14
214
1405
1.64
9.03
3.2
2.5
143.27
121.72
ug/g
0.57
180
1119
106
567
1.95
8.97
1.5
1.5
—
—
—
0
0
420
3215
1.47
8.79
2.8
2.2
258.87
248.89
u/l
0.04
397
3067
37
125
3.02
8.67
2.1
1.8
—
—
—
0
0
44
164
2.75
8.65
1.5
1.3
—
—
—
0
0
1093
10167
1.81
8.26
36.3
19.0
3.98
3.98
mmol/l
0.38
1081
9945
1091
10150
1.80
8.14
35.2
18.9
139.51
139.60
mmol/l
0.63
1080
9953
136
814
1.76
8.06
4.7
4.6
90.92
89.97
ng/l
0.04
121
727
116
664
1.83
7.99
2.1
1.7
—
—
—
0
0
32
105
3.10
7.90
2.7
3.0
—
—
—
0
0
189
1242
1.62
7.89
9.3
8.2
4.88
5.10
kpa
2.26
180
1197
189
1243
1.62
7.86
9.2
8.2
12.14
12.29
kpa
0.16
180
1202
187
1231
1.61
7.74
9.3
8.2
0.31
0.93
mmol/l
1.22
155
1009
32
108
3.02
7.54
1.2
1.1
92.81
94.12
%
0.08
32
99
50
213
2.41
7.53
1.6
1.4
—
—
—
0
0
50
213
2.41
7.53
1.6
1.4
—
—
—
0
0
66
322
2.11
7.22
1.7
1.5
272.71
286.99
ug/g
0.27
35
201
339
2570
1.44
7.19
1.5
1.3
2.38
1.78
u/ml
0.28
88
702
35
128
2.79
7.17
1.9
1.4
—
—
—
0
0
881
7879
1.44
7.11
5.2
4.3
14.78
14.77
pmol/l
0.04
832
7220
34
123
2.82
7.10
2.0
1.5
—
—
—
0
0
34
123
2.82
7.10
2.0
1.5
—
—
—
0
0
34
124
2.79
7.00
2.0
1.5
—
—
—
0
0
35
130
2.74
6.97
1.9
1.4
—
—
—
0
0
35
130
2.74
6.97
1.9
1.4
—
—
—
0
0
244
1745
1.50
6.94
3.8
3.2
1.86
2.09
e6/l
0.24
133
879
38
149
2.60
6.82
1.1
1.1
—
—
—
0
0
119
725
1.71
6.63
6.9
5.0
1.25
1.68
mmol/l
0.71
85
531
18
33
5.52
6.62
1.1
1.2
—
—
—
0
0
29
100
2.95
6.61
1.4
1.2
52.66
81.30
u/l
0.57
29
92
19
50
3.84
6.55
1.1
1.0
1236.53
1480.52
miu/ml
0.46
19
50
53
248
2.19
6.46
1.7
1.5
—
—
—
0
0
167
1117
1.57
6.43
9.6
8.5
95.90
95.65
%
0.20
162
1088
14
19
7.44
6.42
1.6
1.0
—
—
—
0
0
396
3141
1.39
6.36
5.4
3.9
0.00
0.01
estimate
1.34
173
1120
55
264
2.14
6.30
2.7
3.2
3.54
1.86
index
0.35
24
151
129
818
1.65
6.19
3.7
2.7
56.58
67.69
ml/min/173m2
2.36
66
341
16
39
4.14
6.10
3.4
3.1
0.60
0.61
mmol/l
0.34
16
39
12
14
8.64
6.06
3.0
2.9
11.54
18.90
mg/l
—
5
6
21
63
3.37
6.01
1.4
1.4
—
—
—
0
0
930
8489
1.42
5.98
46.2
19.5
14.22
13.59
%
27.87
922
8395
1017
9441
1.50
5.97
30.4
15.3
81.87
81.94
ml/min/173m2
0.03
976
8685
19
54
3.56
5.89
5.9
1.7
26.37
28.19
umol/l
0.23
19
48
22
69
3.23
5.89
1.4
1.7
12.36
13.42
umol/l
0.39
22
63
21
64
3.32
5.87
1.9
1.5
7.27
6.22
u/l
0.09
15
53
26
91
2.90
5.80
2.3
2.8
1669.15
1146.79
mg
0.34
26
91
69
372
1.91
5.77
1.7
1.8
—
—
—
0
0
117
737
1.65
5.76
1.5
1.3
282.67
211.16
u/ml
0.30
98
681
445
3645
1.35
5.70
4.9
3.5
7.56
7.72
mmol/l
0.30
391
3104
23
76
3.07
5.66
1.3
1.4
—
—
—
0
0
25
87
2.91
5.64
1.4
1.5
—
—
—
0
0
29
110
2.68
5.60
4.3
4.0
—
—
—
0
0
23
77
3.03
5.55
1.3
1.4
—
—
—
0
0
272
2065
1.41
5.55
3.0
3.0
2.45
2.45
mmol/l
0.21
253
1851
17
37
4.65
5.49
2.5
2.0
—
—
—
0
0
21
67
3.17
5.48
1.4
1.4
—
—
—
0
0
1003
9337
1.44
5.30
6.4
5.3
1.96
1.92
mu/l
0.30
956
8643
238
1779
1.42
5.28
1.3
1.3
10.69
11.75
u/ml
0.08
82
674
14
26
5.43
5.23
1.1
1.1
98.86
90.35
%
0.27
14
26
22
75
2.97
5.16
1.4
1.4
—
—
—
0
0
68
381
1.83
5.08
1.3
1.3
190.00
250.62
miu/ml
0.64
19
180
125
826
1.57
5.07
3.3
3.5
195.76
211.08
ng/l
0.21
113
757
16
36
4.49
5.06
2.5
2.1
—
—
—
0
0
16
36
4.49
5.06
2.5
2.1
—
—
—
0
0
473
3961
1.32
5.06
5.7
3.9
48.65
64.38
ng/l
0.34
358
2822
18
55
3.31
5.04
1.4
1.1
226.83
87.62
u/l
0.96
18
48
411
3382
1.33
4.95
5.7
4.3
10.95
9.17
mg/mmol
0.30
286
2181
99
625
1.64
4.86
4.2
3.7
4.43
4.59
pmol/l
0.77
92
562
50
257
1.99
4.84
3.1
2.3
123.79
130.05
g/l
1.09
38
206
762
6851
1.31
4.66
4.8
3.3
59.32
47.44
u/l
2.92
724
6453
140
970
1.50
4.59
2.7
2.4
33.27
41.00
u/l
0.63
124
809
124
841
1.53
4.50
2.7
2.4
4.95
6.81
ug/l
1.30
114
750
54
297
1.86
4.31
1.3
1.2
—
—
—
0
0
130
901
1.50
4.26
3.2
2.5
0.65
0.48
e6/l
0.29
123
859
1094
10456
1.51
4.08
24.5
11.7
26.97
25.88
u/l
0.71
1080
10167
18
63
2.89
4.07
1.7
1.3
—
—
—
0
0
18
63
2.89
4.07
1.7
1.3
—
—
—
0
0
53
296
1.83
4.05
1.3
1.2
—
—
—
0
0
26
111
2.37
4.01
1.5
1.6
64.44
60.04
%
0.25
18
78
16
53
3.05
3.97
1.3
1.2
28.62
17.59
u/l
0.55
16
46
30
138
2.20
3.91
1.1
1.0
—
—
—
0
0
38
193
2.00
3.86
3.5
2.8
10.45
8.97
pmol/l
0.29
38
193
50
281
1.81
3.77
1.4
1.3
—
—
—
0
0
27
121
2.26
3.75
1.3
1.2
—
—
—
0
0
28
128
2.22
3.72
9.3
6.6
6.88
7.34
mmol/l
0.49
23
107
1100
10554
1.49
3.71
41.0
20.5
80.05
77.79
umol/l
1.41
1092
10430
492
4274
1.26
3.61
5.1
3.8
0.04
0.03
estimate
0.18
158
1017
14
40
3.53
3.61
1.9
1.8
39.25
39.30
g/l
0.01
14
40
13
35
3.74
3.59
1.2
1.1
91.38
96.52
%
—
8
29
7
9
7.81
3.56
1.1
1.0
—
—
—
0
0
16
57
2.83
3.53
2.0
1.7
—
—
—
0
0
9
17
5.33
3.51
1.8
1.4
—
—
—
0
0
13
36
3.64
3.50
1.2
1.4
—
—
—
0
0
9
18
5.03
3.37
1.3
1.0
—
—
—
0
0
16
61
2.64
3.14
3.9
1.4
10.72
23.57
umol/l
2.62
16
52
14
50
2.82
3.09
1.8
1.3
—
—
—
0
0
14
50
2.82
3.09
1.8
1.3
—
—
—
0
0
6
8
7.53
3.05
4.8
6.1
—
—
—
0
0
7
12
5.86
3.02
2.0
1.5
—
—
—
0
0
46
271
1.73
3.01
1.6
1.6
32194.56
14871.12
e6/l
1.00
36
188
18
75
2.42
2.97
3.1
2.3
803.00
617.42
ml
0.75
13
45
72
478
1.54
2.95
1.7
1.7
0.27
0.31
mg/l
0.35
26
225
73
490
1.52
2.85
6.6
5.8
24.75
24.64
mmol/l
0.13
68
465
23
111
2.09
2.74
1.5
1.4
0.18
0.19
nmol/l
0.05
17
85
7
14
5.02
2.73
1.0
1.3
—
—
—
0
0
40
235
1.73
2.67
3.5
3.5
0.71
0.84
nmol/l
1.03
27
193
358
3086
1.23
2.66
4.6
3.3
0.03
0.05
estimate
0.29
156
973
23
114
2.04
2.57
1.2
1.4
76922.82
82043.32
e6/l
0.03
17
62
5
7
7.17
2.55
1.0
3.7
—
—
—
0
0
707
6528
1.20
2.51
3.6
3.2
—
—
—
0
0
35
202
1.75
2.50
1.4
1.1
6.63
16.25
au/ml
—
6
54
242
2013
1.25
2.48
5.2
4.0
568.06
420.07
ng/l
0.23
199
1553
26
139
1.89
2.37
1.2
1.1
—
—
—
0
0
243
2033
1.24
2.36
1.6
1.6
—
—
—
0
0
24
126
1.92
2.32
1.5
1.4
0.57
14.76
nmol/l
0.50
24
120
10
36
2.79
2.14
1.2
1.1
—
—
—
0
0
960
9186
1.22
2.10
7.6
6.4
39.42
39.26
mmol/mol
0.20
912
8604
132
1042
1.30
2.07
4.0
4.4
17.02
26.97
ug/l
0.37
112
855
39
246
1.60
2.06
1.4
1.2
—
—
—
0
0
7
20
3.51
2.05
1.1
1.2
—
—
—
0
0
38
240
1.60
2.00
3.3
2.4
128.30
99.83
ug/min
0.18
25
142
6
16
3.76
1.93
1.2
1.2
—
—
—
0
0
9
33
2.74
1.93
1.2
1.4
—
—
—
0
0
15
71
2.13
1.92
1.8
1.4
—
—
—
0
0
14
65
2.17
1.88
1.0
1.1
—
—
—
0
0
9
34
2.66
1.86
1.3
1.2
11.21
8.72
ug/l
—
9
34
73
537
1.38
1.85
1.4
1.3
—
—
—
0
0
12
53
2.28
1.81
1.2
1.1
356.32
175.62
iu/ml
0.63
12
53
981
9450
1.21
1.76
5.8
5.0
6.05
5.94
mmol/l
0.93
916
8655
101
793
1.30
1.69
1.4
1.5
—
—
—
0
0
6
19
3.17
1.66
1.5
1.3
—
—
—
0
0
45
310
1.47
1.66
1.7
1.5
—
—
—
0
0
55
396
1.41
1.61
5.1
3.5
1302.63
3874.01
u/ml
0.48
48
340
6
20
3.01
1.58
1.5
1.4
—
—
—
0
0
951
9161
1.18
1.58
4.7
4.2
1.37
1.27
mmol/l
3.91
889
8432
14
71
1.98
1.54
1.2
1.5
—
—
—
0
0
286
2531
1.17
1.53
5.0
4.0
1.02
1.02
kg/l
0.05
195
1680
5
15
3.34
1.52
2.8
1.9
—
—
—
0
0
7
27
2.60
1.51
1.9
3.6
6.43
6.40
ug/l
—
7
27
13
65
2.01
1.49
1.2
1.2
—
—
—
0
0
13
65
2.01
1.49
1.4
1.3
12.47
5.95
ug/l
1.66
13
54
9
38
2.38
1.45
1.2
1.1
—
—
—
0
0
25
156
1.62
1.44
1.3
1.5
30.00
31.20
g/l
0.25
25
142
151
1269
1.22
1.44
1.9
1.8
1.52
1.47
%
0.33
132
1112
42
295
1.44
1.43
2.4
2.0
3.52
4.34
iu/l
0.44
26
120
16
88
1.83
1.42
1.3
1.1
109.31
103.05
pmol/l
0.13
16
88
1114
10919
1.27
1.40
60.0
24.2
178.02
250.27
e9/l
98.16
1101
10708
1114
10922
1.27
1.37
59.6
24.1
90.97
90.87
fl
0.26
1106
10806
6
23
2.62
1.37
1.0
1.2
—
—
—
0
0
23
143
1.62
1.36
2.3
1.6
19.05
24.82
ng/l
0.93
23
143
1114
10924
1.26
1.35
60.7
24.6
39.67
40.22
%
3.76
1105
10800
1114
10924
1.26
1.35
59.8
24.1
4.41
4.49
e12/l
4.89
1099
10686
20
120
1.68
1.34
3.7
2.5
46.29
18.14
mg/l
—
7
45
1114
10927
1.26
1.33
59.9
24.2
7.22
6.84
e9/l
2.38
1102
10685
1114
10928
1.26
1.32
60.3
24.3
131.36
134.78
g/l
11.10
1105
10809
1009
9808
1.18
1.31
6.1
5.6
2.51
2.67
mmol/l
7.01
955
9119
996
9674
1.17
1.29
5.5
5.0
4.31
4.56
mmol/l
11.74
939
9044
10
48
2.09
1.28
2.6
2.1
76.34
88.09
ug/l
—
10
48
20
122
1.65
1.28
1.7
1.4
—
—
—
0
0
17
102
1.68
1.16
1.0
1.1
—
—
—
0
0
18
111
1.63
1.12
1.0
1.1
—
—
—
0
0
7
30
2.34
1.12
2.9
1.4
148.00
84.43
nmol/24h
—
7
30
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
12
66
1.83
1.09
1.0
1.1
—
—
—
0
0
8
41
1.96
1.09
2.6
1.7
0.53
0.50
e9/l
—
8
41
15
89
1.69
1.08
3.7
3.6
9.00
12.17
index
—
8
63
38
280
1.37
1.05
1.6
1.4
573.82
466.97
mg/l
0.61
38
267
91
754
1.22
1.04
1.3
1.2
108.13
150.48
u/ml
0.68
38
292
9
48
1.88
1.00
2.6
4.2
—
—
—
0
0
986
9616
1.14
1.00
5.4
4.9
1.35
1.44
mmol/l
9.52
928
8919
9
49
1.84
0.98
1.3
1.2
—
—
—
0
0
69
842
0.81
0.95
2.8
2.1
—
—
—
0
0
14
85
1.65
0.94
1.8
1.4
—
—
—
0
0
7
37
1.90
0.94
1.0
1.2
—
—
—
0
0
34
252
1.36
0.92
1.7
1.3
22.60
15.23
e6/l
0.14
25
185
18
118
1.53
0.91
1.0
1.1
—
—
—
0
0
8
43
1.87
0.87
1.1
1.0
—
—
—
0
0
34
255
1.34
0.87
1.7
1.4
94.85
671.88
e6/l
0.67
26
196
8
45
1.78
0.84
1.0
1.0
—
—
—
0
0
17
113
1.51
0.82
1.2
1.2
—
—
—
0
0
13
81
1.61
0.81
1.2
1.3
14.00
10.96
u/l
0.42
13
74
249
2702
0.90
0.76
4.4
4.6
22.76
21.56
%
0.62
128
1341
45
360
1.26
0.75
1.5
1.5
10.15
8.72
u/l
0.26
37
283
56
464
1.22
0.70
2.2
2.3
6604.90
6536.07
u/l
0.00
25
201
135
1208
1.13
0.67
4.8
4.8
30.31
32.26
%
1.09
95
806
14
200
0.70
0.63
1.6
1.7
—
—
—
0
0
863
8428
1.08
0.62
48.9
20.5
331.14
332.56
g/l
4.20
858
8381
23
300
0.76
0.60
1.5
1.5
—
—
—
0
0
8
52
1.54
0.59
1.1
1.2
8.38
9.10
mm/h
—
8
52
8
54
1.48
0.57
1.4
1.2
18.49
33.52
nmol/l
—
8
46
8
54
1.48
0.57
2.8
2.1
—
182.11
—
0
9
185
2004
0.91
0.57
2.9
3.3
0.73
0.76
ug/l
0.29
126
1310
14
98
1.43
0.56
1.1
1.2
1.23
3.25
u/ml
—
8
53
79
693
1.15
0.55
2.7
2.5
48.38
18.06
au/ml
—
5
59
11
75
1.47
0.50
2.0
1.4
90.45
81.52
umol/l
0.48
11
75
61
700
0.86
0.50
2.3
2.0
—
—
—
0
0
49
418
1.18
0.49
1.3
1.4
—
—
—
0
0
12
85
1.42
0.47
1.2
1.1
211.17
236.15
mg/l
0.31
12
72
29
351
0.82
0.44
1.2
1.2
1.41
1.53
g/l
1.86
29
351
124
1138
1.10
0.44
11.6
7.2
—
—
—
0
0
5
31
1.62
0.43
1.6
1.8
—
—
—
0
0
8
56
1.43
0.42
3.1
2.3
—
—
—
0
0
6
93
0.64
0.42
1.2
1.9
—
—
—
0
0
5
32
1.56
0.42
2.6
3.2
10.18
10.24
kpa
—
5
32
5
32
1.56
0.42
2.6
3.2
5.12
4.88
kpa
—
5
32
20
158
1.27
0.42
1.1
1.1
2.06
1.94
eliau/ml
—
5
60
80
888
0.89
0.42
2.3
2.3
11.08
12.46
nmol/l
0.88
72
793
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
5
34
1.47
0.40
1.0
1.1
—
—
—
0
0
5
34
1.47
0.40
1.0
1.1
—
—
—
0
0
5
34
1.47
0.40
1.0
1.1
—
—
—
0
0
33
279
1.19
0.39
1.7
1.7
—
—
—
0
0
57
505
1.14
0.38
1.5
1.4
27.57
24.52
iu/l
0.26
47
416
36
309
1.17
0.36
1.7
1.6
—
—
—
0
0
143
1526
0.93
0.34
1.8
1.5
—
—
—
0
0
22
181
1.22
0.34
1.2
1.3
—
—
—
0
0
6
45
1.33
0.33
1.0
1.2
—
—
—
0
0
17
210
0.81
0.33
1.2
1.4
115.41
262.22
pmol/l
1.02
17
205
348
3362
1.05
0.31
5.3
5.6
2.33
2.75
ug/l
0.50
316
3010
8
63
1.27
0.27
2.8
3.7
0.63
0.86
index
—
8
63
8
64
1.25
0.27
2.8
1.7
95.91
101.61
ng/l
—
8
64
8
66
1.21
0.26
1.0
1.0
237.13
263.88
ng/l
—
8
43
15
125
1.20
0.22
6.5
2.0
13.32
13.12
%
0.26
15
125
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.7
—
0.55
—
0
11
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
27
239
1.13
0.21
1.3
1.6
46.44
54.73
ug/l
0.63
27
239
46
421
1.10
0.21
2.0
1.6
283.88
288.07
mu/l
0.03
40
384
98
1036
0.94
0.21
1.7
1.9
3.41
3.47
ratio
0.15
69
805
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
73
778
0.93
0.20
1.5
1.7
3.39
3.44
mmol/l
0.11
46
552
10
81
1.24
0.18
1.2
1.0
—
—
—
0
0
7
58
1.21
0.18
1.6
1.3
—
—
—
0
0
35
381
0.92
0.16
3.1
1.7
10.32
3.69
mg/l
0.87
26
282
53
563
0.94
0.14
1.0
1.0
—
—
—
0
0
35
374
0.93
0.11
1.4
1.6
54.85
63.15
ug/l
0.81
30
321
32
340
0.94
0.09
1.4
1.5
—
—
—
0
0
139
1422
0.97
0.09
2.2
2.2
—
—
—
0
0
16
146
1.10
0.08
1.1
1.3
—
—
—
0
0
24
225
1.07
0.07
1.2
1.1
21.86
5.64
u/ml
0.42
12
134
128
1307
0.98
0.07
2.1
2.1
—
—
—
0
0
7
82
0.85
0.07
1.3
1.2
—
—
—
0
0
67
650
1.03
0.07
1.6
1.6
802.92
991.30
mu/l
1.56
58
555
35
365
0.96
0.06
1.6
1.2
0.90
0.89
g/l
0.08
35
365
33
344
0.96
0.05
1.4
1.5
1.12
1.17
ratio
0.14
21
222
33
344
0.96
0.05
1.4
1.5
0.90
0.92
ratio
0.29
21
222
33
344
0.96
0.05
1.4
1.5
1.29
1.19
ratio
0.24
21
222
21
209
1.00
0.00
4.2
3.8
23.74
27.29
mg/l
0.28
16
148
26
261
1.00
0.00
1.3
1.1
1.38
3.20
u/ml
1.30
15
157
32
325
0.98
0.00
1.4
1.8
48.72
39.55
nmol/l
1.01
32
310
23
225
1.02
0.00
1.1
1.1
0.49
1.80
u/ml
—
9
130
410
4099
1.00
0.00
2.2
1.9
1.43
1.33
mmol/l
1.32
340
3450
16
155
1.03
0.00
1.6
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
59
0.85
0.00
1.0
1.0
19.00
19.12
mmol/l
—
5
53
5
56
0.89
0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
9.43
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
3.00
—
0
5
5
51
0.98
-0.00
1.0
1.0
7.84
7.53
kpa
—
5
46
0
5
0.00
-0.00
0.0
1.6
—
471.60
—
0
5
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
6.18
—
0
9
Mortality – FinRegistry
↥Association
Association between endpoint D3_ITP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ITP | 2.136 [1.84, 2.48] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.023 |
During the follow-up period (1.1.1998 — 31.12.2019), 792 out of 3356 females with D3_ITP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ITP | 2.157 [1.83, 2.54] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 954 out of 3358 males with D3_ITP died.
Mortality risk
Mortality risk for people of age
years, who have D3_ITP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.16% | 0.403% |
| 5 | 0.979% | 2.627% |
| 10 | 2.315% | 6.513% |
| 15 | 4.587% | 11.842% |
| 20 | 8.251% | 20.907% |
Relationships between endpoints
↥Index endpoint: D3_ITP – Idiopathic thrombocytopenic purpura
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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