Benign neoplasm: Retina

CD2_BENIGN_RETINA

retinal cancer: A malignant neoplasm involving the retina.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D31.2& Hospital discharge: ICD-9 — 2245 Hospital discharge: ICD-8 — 22404 Cause of death: ICD-10 — D31.2& Cause of death: ICD-9 — 2245 Cause of death: ICD-8 — 22404 2 out of 7 registries used, show all original rules.	239
4. Check minimum number of events None	239
5. Include endpoints None	239
6. Filter based on genotype QC (FinnGen only)	202

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D31
Name in latin: Neoplasma benignum retinae

NAME	CD2_BENIGN_RETINA
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D312
HD_ICD_9	2245
HD_ICD_8	22404
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D312
COD_ICD_9	2245
COD_ICD_8	22404
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm: Retina based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1303	829	465
Only index persons	1197	785	412
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.01
Only index persons	0.02	0.03	0.02
Median age at first event (years)
Whole population	60.48	61.23	59.15
Only index persons	60.20	61.07	58.54

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	202	118	84
Unadjusted period prevalence (%)	0.04	0.04	0.04
Median age at first event (years)	60.20	56.81	64.97

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
208: Matched controls
2080

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D31.2

ICD-10 Finland

Benign neoplasm: Retina

+∞

294.8

206

D31.3

ICD-10 Finland

Benign neoplasm: Choroid

66.6

102.7

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

12.0

45.6

XCK10

NOMESCO Finland

Photography of fundus of eye

8.6

43.2

114

CK2L4

NOMESCO Finland

Wide-field/panoramic imaging of ocular fundus

94.3

23.2

XCW99

NOMESCO Finland

Other investigative procedure of eye

5.4

20.4

107

XCD10

NOMESCO Finland

Electrophysiological examination of eye

17.0

20.2

Z01.0

ICD-10 Finland

Examination of eyes and vision

3.8

17.3

244

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

4.7

17.0

119

Z3229

NOMESCO Finland

Other healthcare associate professional

3.7

9.5

101

CKC20

NOMESCO Finland

Cryopexy of undetached retina

52.2

8.8

XCD20

NOMESCO Finland

Photoangiography of eye

10.7

8.7

WX140

NOMESCO Finland

Parabulbar anesthesy

4.4

8.3

C69.30

ICD-10 Finland

Malignant tumor of the chorioidea without histology

41.4

6.8

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

2.8

6.7

143

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

6.88

3.71

1.0

1.3

—

(3026008) Bacteria identified in Urine by Culture

554

1.72

3.42

3.1

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

4.65

3.15

1.2

—

(3049717) Cytology report of Urine Cyto stain

2.59

3.04

2.6

2.8

—

(3030467) Casts [#/volume] in Urine by Automated count

516

1.67

3.02

3.5

3.2

0.07

0.51

e6/l

2.54

367

(3035637) Corticotropin [Mass/volume] in Plasma

5.53

2.89

4.0

1.6

19.43

45.77

ng/l

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

198

1.92

2.87

2.4

3.1

5.17

7.82

umol/l

1.15

173

(46236952) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)/1.73 sq M

139

2.08

2.86

5.7

2.4

58.06

65.73

ml/min/173m2

0.58

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

295

1.77

2.78

2.6

2.9

0.83

0.93

e6/l

0.10

146

(3018418) pH of Serum or Plasma

563

1.62

2.73

5.2

4.1

7.39

7.40

0.07

403

(3037121) Protein [Mass/volume] in Urine

2.57

2.68

3.8

3.0

417.83

206.00

mg/l

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

105

816

1.58

2.68

2.8

2.5

77.80

77.58

nmol/l

0.03

728

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

115

2.12

2.63

1.3

49.37

166.37

u/ml

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

114

907

1.57

2.61

9.0

7.3

1.22

1.21

mmol/l

0.50

784

(3041096) Erythrocytes [Presence] in Urine by Automated

551

1.56

2.39

3.1

3.6

0.45

0.15

estimate

0.28

168

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

644

1.54

2.35

3.7

3.4

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

159

1383

1.64

2.35

5.7

4.5

14.69

14.82

pmol/l

0.31

148

1259

(3002582) Erythrocytes [#/volume] in Urine

600

1.54

2.31

3.8

3.4

18.73

146.59

e6/l

0.61

449

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

278

1.69

2.28

2.0

2.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

143

1220

1.55

2.23

5.1

4.6

—

2.71

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

116

2.00

2.21

5.0

7.6

24.81

24.70

mmol/l

0.04

116

(3020891) Body temperature

2.20

2.19

3.1

3.6

36.68

36.97

°c

2.01

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

727

1.51

2.19

3.8

4.1

0.00

0.01

estimate

0.80

174

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

571

1.52

2.15

3.2

3.5

722.54

1377.71

ng/l

2.73

476

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

182

1652

1.81

2.15

7.0

5.4

2.00

1.90

mu/l

0.55

172

1518

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

110

2.01

2.14

6.9

9.4

1.18

1.35

0.39

110

(3032080) INR in Blood by Coagulation assay

104

836

1.49

2.12

15.3

14.3

1.22

1.24

inr

0.15

682

(3035350) Ketones [Presence] in Urine by Test strip

116

956

1.48

2.07

4.1

4.2

0.00

estimate

-0.00

216

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

101

811

1.48

2.05

7.8

6.1

1.21

1.22

mmol/l

0.12

742

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.11

2.02

1.6

1.7

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

107

873

1.46

1.98

3.1

3.0

118.15

115.56

ug/l

0.04

102

816

(3021601) Nitrite [Presence] in Urine by Test strip

114

943

1.46

1.95

4.1

4.2

0.00

estimate

-0.00

208

(1616796) Gas panel - Central venous blood

2.80

1.95

4.6

3.1

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

266

1.62

1.90

3.3

3.1

3.31

2.51

e6/l

0.25

119

(40768797) Stomach Pathology biopsy report

234

1.65

1.87

1.4

1.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.00

1.87

1.6

1.3

—

(3019977) pH of Arterial blood

194

1.70

1.85

5.7

7.6

7.40

7.41

0.45

120

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

109

1.92

1.85

7.4

9.5

0.73

0.65

0.40

109

(3010813) Leukocytes [#/volume] in Blood

199

1886

2.27

1.84

30.4

24.8

6.66

6.71

e9/l

0.13

194

1851

(3026361) Erythrocytes [#/volume] in Blood

199

1886

2.27

1.84

30.2

24.7

4.47

e12/l

0.02

194

1851

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

3.11

1.81

4.1

1.3

—

nmol/l

—

(3018095) Leukocytes [#/volume] in Urine

693

1.44

1.78

4.6

4.1

89.82

80.28

e6/l

0.07

478

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

104

1.91

1.74

7.4

9.5

23.72

24.34

mmol/l

0.26

104

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

153

1357

1.48

1.71

4.5

4.3

12.06

12.07

mm/h

0.00

144

1243

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.10

1.69

1.9

2.3

—

(3012544) pH of Venous blood

176

1.68

1.65

2.3

3.8

7.38

0.03

106

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

187

1740

1.74

1.62

19.8

16.4

23.51

21.67

mg/l

0.34

163

1418

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

2.56

1.61

2.1

1.9

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

790

1.40

1.59

5.0

4.9

36.10

35.71

g/l

0.29

755

(3009261) Glucose [Presence] in Urine by Test strip

114

966

1.40

1.59

4.2

0.00

1.50

estimate

0.50

200

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.90

1.57

1.4

1.3

36.68

29.08

iu/l

0.33

(3003396) Base excess in Arterial blood by calculation

195

1.63

1.57

5.8

7.5

0.50

0.89

mmol/l

0.15

166

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

326

1.49

1.47

4.6

3.9

427.97

159.33

ng/l

0.61

257

(3019150) Specific gravity of Urine by Refractometry

424

1.44

1.47

3.6

4.2

1.02

kg/l

0.27

279

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

3.17

1.44

4.2

4.0

69.20

184.62

nmol/l

—

(3016018) Differential panel - Cerebral spinal fluid

3.17

1.44

1.2

1.1

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.00

1.41

1.7

2.1

—

(3044640) Blood type and Crossmatch panel - Blood

593

1.38

1.40

2.2

2.4

—

(36660697) Celiac disease serology panel - Serum

136

1.69

1.39

1.1

1.2

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

2.99

1.36

1.4

—

(3000991) Gas panel - Venous blood

146

1.65

1.33

6.8

8.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

405

1.41

1.32

4.0

3.9

—

0.20

—

(3000494) Fungus identified in Specimen by Culture

221

1.53

1.31

1.4

1.5

—

(3022621) pH of Urine by Test strip

147

1.63

1.29

1.8

2.3

6.27

6.14

0.30

103

(3018677) aPTT in Platelet poor plasma by Coagulation assay

265

1.48

1.28

1.6

1.9

29.56

29.12

0.16

260

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

821

1.34

1.28

2.3

2.0

99.57

97.32

pmol/l

0.15

429

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

764

1.34

1.26

2.1

2.0

1.38

1.36

mmol/l

0.10

638

(3042936) Bacteria identified in Isolate by Culture

249

1.49

1.26

1.8

2.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

833

1.33

1.25

2.7

2.8

—

estimate

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

383

1.40

1.22

1.6

1.8

496.51

457.82

pmol/l

0.34

330

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

2.67

1.22

3.8

1.2

—

nmol/l

—

(3042631) Mycobacterium sp identified in Specimen

2.35

1.19

1.8

3.8

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

2.54

1.16

1.0

1.1

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

1.15

0.0

1.1

—

(3048689) Calprotectin [Mass/mass] in Stool

220

1.48

1.13

2.0

1.9

123.60

119.44

ug/g

0.03

173

(3013650) Neutrophils [#/volume] in Blood by Automated count

118

1040

1.31

1.12

11.0

9.7

4.22

4.07

e9/l

0.29

107

913

(3035715) Granulocytes [#/volume] in Blood

2.30

1.11

5.6

2.1

3.67

5.58

e9/l

—

(3015736) pH of Urine

766

1.31

1.10

3.8

3.7

6.18

6.19

0.02

435

(3014148) Varicella zoster virus Ab [Titer] in Serum

2.41

1.09

1.0

1.2

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

2.23

1.09

2.0

1.5

22.37

121.01

u/ml

—

(3026389) Candida sp identified in Specimen by Organism specific culture

2.30

1.04

1.0

1.4

—

(3010421) pH of Blood

1.93

1.03

5.7

3.6

7.41

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.93

1.03

2.3

2.8

—

(40761511) CBC panel - Blood by Automated count

189

1800

1.55

1.01

18.6

14.7

—

(3044290) Cell count panel - Cerebral spinal fluid

2.03

1.01

1.1

1.2

—

(3029937) Albumin [Presence] in Urine by Test strip

545

1.31

0.99

3.9

4.3

0.00

estimate

-0.00

197

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.98

0.0

1.5

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

210

1.44

0.97

3.2

4.6

4.99

10.62

ug/l

1.05

171

(40768804) Tissue Pathology biopsy report

728

1.28

0.97

2.4

2.1

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

245

1.41

0.97

5.8

6.8

103.33

103.96

mmol/l

0.44

245

(3019060) Gas panel - Arterial blood

101

1.63

0.97

2.6

3.5

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.66

0.96

3.2

2.4

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

719

1.28

0.96

4.3

36.13

41.27

ng/l

0.18

514

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

2.26

0.94

1.0

—

21.20

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

203

1.44

0.93

1.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

186

1.45

0.93

1.9

2.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

204

1.43

0.91

1.8

1.7

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.85

0.87

1.5

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.63

0.87

1.4

1.3

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

651

1.26

0.85

3.5

3.4

2.34

2.35

mmol/l

0.76

596

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

1.73

0.84

1.8

1.5

435.36

387.18

ug/l

0.07

(3043409) Potassium [Moles/volume] in Arterial blood

1.73

0.81

3.0

3.2

3.90

4.01

mmol/l

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.73

0.81

1.1

1.3

—

(40768443) Skin Pathology biopsy report

1.60

0.80

1.2

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.79

0.0

1.1

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.79

0.0

1.2

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

1.84

0.79

1.0

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.69

0.79

1.1

1.2

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.79

0.0

1.6

—

(3002256) Pathology report gross observation

237

1.36

0.78

1.4

1.2

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

2.11

0.75

1.4

1.1

—

(3019069) Monocytes/Leukocytes in Blood

874

1.23

0.75

7.9

6.0

9.06

8.66

0.61

827

(3020779) Urea [Moles/volume] in Serum or Plasma

151

1.43

0.75

5.9

7.7

8.75

9.70

mmol/l

0.31

144

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.56

0.74

1.0

—

(3027315) Oxygen [Partial pressure] in Blood

1.87

0.74

4.7

3.1

8.49

8.30

kpa

—

(3013290) Carbon dioxide [Partial pressure] in Blood

1.87

0.74

4.7

3.1

5.17

5.03

kpa

—

(3023368) Bacteria identified in Blood by Culture

498

1.26

0.74

4.8

4.6

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

423

1.27

0.74

4.2

5.0

21.56

21.91

0.07

223

(4024509) Urine culture

1.61

0.73

2.3

1.9

—

(40758558) Short blood count panel - Blood

557

1.24

0.71

7.7

6.3

—

(3026725) Estradiol (E2) [Moles/volume] in Serum or Plasma

1.95

0.71

2.0

1.4

0.73

0.26

nmol/l

—

(3019309) Folate [Moles/volume] in Red Blood Cells

314

1.30

0.71

1.6

1.7

1366.10

1259.48

nmol/l

0.29

240

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

435

1.26

0.70

2.1

2.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

325

0.74

0.70

2.3

1.9

—

(42870588) Differential panel, method unspecified - Blood

597

1.23

0.69

8.4

5.6

—

(3002030) Lymphocytes/Leukocytes in Blood

890

1.21

0.68

8.4

6.0

26.54

27.28

0.22

850

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

446

1.25

0.68

1.4

1.3

0.65

1.38

u/ml

0.84

136

(3020682) Albumin/Creatinine [Ratio] in Urine

609

1.23

0.67

4.4

4.0

17.84

7.84

mg/mmol

0.50

383

(3022096) Basophils/Leukocytes in Blood

873

1.21

0.66

8.0

6.0

0.64

0.66

0.19

819

(3013139) Helicobacter pylori Ag [Presence] in Stool

121

1.44

0.64

1.1

1.2

—

(3002179) Metamyelocytes/Leukocytes in Blood

156

1.39

0.64

3.8

5.2

0.43

0.53

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

1.62

0.63

3.8

2.5

1.22

1.52

mg/l

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.66

0.63

1.1

1.2

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.66

0.63

1.1

1.2

—

(3012516) Albumin [Mass/volume] in Urine

594

1.22

0.62

3.6

3.3

110.17

48.05

mg/l

0.60

390

(3013512) EKG study

633

1.21

0.61

4.0

3.8

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.60

0.0

1.2

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.60

0.0

1.2

—

(40768795) Lymph node Pathology biopsy report

0.00

0.60

0.0

1.2

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.58

0.0

1.9

—

(21494755) Public health laboratory ask at order entry panel

171

0.68

0.57

1.3

1.4

—

(3006504) Eosinophils/Leukocytes in Blood

873

1.19

0.56

8.0

5.9

3.05

2.80

0.43

823

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

1.64

0.56

1.0

1.4

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

486

1.21

0.54

2.6

2.1

2.49

2.81

mg/l

0.67

430

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

1.55

0.53

2.2

1.7

—

(3006315) Basophils [#/volume] in Blood

103

946

1.18

0.53

7.7

5.8

0.04

e9/l

0.13

822

(3019198) Lymphocytes [#/volume] in Blood

104

958

1.17

0.51

8.1

5.9

1.68

1.96

e9/l

1.41

854

(3000492) Spirometry study

172

1.31

0.50

1.5

—

(4035726) Immunohistochemistry procedure

172

1.31

0.50

1.3

1.4

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

172

1654

1.23

0.50

7.2

6.6

39.94

39.44

mmol/mol

0.31

161

1563

(3045424) Erythrocytes [Presence] in Urine

1.42

0.49

2.1

2.6

0.00

estimate

—

(3009508) Creatinine [Moles/volume] in Urine

636

1.18

0.49

3.5

3.1

6.14

7.75

mmol/l

4.52

535

(3035933) Granulocytes/Leukocytes in Blood

1.51

0.48

5.6

2.2

55.71

63.42

—

(3001604) Monocytes [#/volume] in Blood

102

942

1.16

0.47

7.7

5.8

0.62

0.58

e9/l

0.85

819

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.47

0.47

1.4

1.3

—

(3013115) Eosinophils [#/volume] in Blood

105

973

1.16

0.46

7.9

6.0

0.18

e9/l

0.00

858

(3021589) Normoblasts [#/volume] in Blood

816

1.16

0.45

16.1

12.2

0.00

e9/l

0.56

675

(3003327) Ova and parasites identified in Stool by Light microscopy

1.39

0.44

1.9

1.7

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

0.62

0.43

1.5

2.0

1.35

1.50

g/l

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.41

0.0

1.2

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.41

0.0

1.2

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.41

0.0

1.1

—

(3000242) Tau protein [Mass/volume] in Cerebral spinal fluid

0.00

0.41

0.0

1.0

—

317.67

—

(3042810) Amyloid beta 42 peptide [Mass/volume] in Cerebral spinal fluid

0.00

0.41

0.0

1.0

—

443.80

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

0.41

0.0

1.2

—

(43055225) Phosphorylated tau 181 [Mass/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.41

0.0

1.0

—

45.79

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.3

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.41

0.0

1.0

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.2

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.40

0.0

1.2

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

1.44

0.39

1.0

1.5

—

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

0.00

0.39

0.0

1.1

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.39

0.0

2.6

—

(3003694) ABO and Rh group [Type] in Blood

493

1.16

0.37

1.5

1.4

—

(1002224) Polysomnography panel

1.35

0.36

1.0

1.1

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

175

1699

1.19

0.36

6.1

5.2

5.96

5.93

mmol/l

0.12

162

1567

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.33

0.36

3.6

3.4

-0.58

1.59

mmol/l

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

1.41

0.35

4.7

2.5

8.88

8.84

pmol/l

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

220

0.80

0.34

1.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

284

0.82

0.34

1.9

1.7

—

(3017181) Myelocytes/Leukocytes in Blood

165

1.23

0.32

4.2

5.3

0.83

0.89

—

(40760892) CBC W Ordered Manual Differential panel - Blood

431

1.15

0.32

4.9

5.0

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

170

1652

1.16

0.31

4.9

4.3

1.31

1.27

mmol/l

0.34

157

1516

(3052851) Hemolysis interference index of Serum or Plasma

1.36

0.31

3.7

3.1

—

2.32

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

336

1.16

0.31

1.2

1.3

31.87

34.10

iu/ml

0.04

110

(3007566) Smooth muscle Ab [Titer] in Serum

1.31

0.30

1.1

—

106.67

—

(3034770) Mitochondria Ab [Titer] in Serum

1.28

0.30

1.6

1.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

186

1.20

0.29

3.8

3.6

—

(4034850) Laboratory test

1.24

0.29

10.6

11.0

—

(40768793) Breast Pathology biopsy report

1.30

0.28

1.3

1.4

—

(3045414) Leukocytes [Presence] in Urine

169

1.20

0.27

1.8

2.3

0.00

estimate

—

(3016879) Cocaine [Presence] in Urine

0.70

0.26

1.0

1.3

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.67

0.26

1.8

0.90

3.86

mg/l

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

428

1.13

0.26

1.6

1.7

1.23

1.40

mg/l

0.17

338

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.26

0.26

1.1

2.2

9.81

10.16

g/l

—

(3008898) HLA-B27 [Presence]

1.24

0.26

1.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

124

1.23

0.24

1.5

1.6

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

179

0.83

0.24

1.5

1.6

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

538

1.11

0.23

5.3

5.9

2.27

2.83

ug/l

0.38

480

(3025941) Bacteria identified in Stool by Culture

1.25

0.23

1.4

1.3

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

230

0.86

0.22

4.8

4.9

31.15

31.88

0.09

147

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

0.21

0.0

1.5

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

20.1

—

849.73

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.2

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.21

0.0

2.2

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.2

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.0

—

(40758292) HTLV I+II Ab panel - Serum

0.00

0.21

0.0

1.6

—

(3017704) Immunofixation for Urine

0.00

0.21

0.0

1.6

—

(3028433) Virus identified in Specimen by Culture

0.00

0.21

0.0

1.2

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

0.21

0.0

1.7

—

150.20

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

173.57

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.21

0.0

1.1

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.21

0.0

3.5

—

0.85

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

174

1.17

0.20

2.4

2.0

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.20

0.0

1.1

—

(3028026) IgM [Mass/volume] in Serum or Plasma

132

0.82

0.19

3.0

1.5

1.18

1.23

g/l

0.12

119

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.75

0.17

1.6

1.1

0.86

0.89

g/l

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.73

0.17

1.8

1.6

—

7.81

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

187

1.14

0.16

2.3

2.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

313

1.10

0.16

1.4

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

1.10

0.16

2.8

4.9

0.98

0.85

—

(3022313) Gas panel - Capillary blood

1.15

0.15

4.0

3.6

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

179

1764

1.11

0.15

6.9

5.9

2.70

2.69

mmol/l

0.03

162

1637

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.12

0.15

2.3

1.9

—

(3022145) Colonoscopy Study observation

221

1.10

0.11

1.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

198

0.90

0.11

9.4

7.4

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

171

1688

1.07

0.11

21.6

16.0

79.10

80.27

ml/min/173m2

0.28

159

1567

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

207

0.91

0.10

2.2

2.1

3.56

3.42

ratio

0.16

174

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

1.11

0.10

1.4

2.2

167.60

207.13

pmol/l

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

1.09

0.09

1.2

—

(40761536) Microorganisms panel - Urine sediment

145

1.11

0.09

5.2

4.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

112

1096

1.05

0.09

3.2

3.1

—

(3007164) IgA [Mass/volume] in Serum or Plasma

400

1.06

0.09

1.7

1.4

2.28

2.52

g/l

0.30

251

(3019832) Treponema pallidum Ab [Presence] in Serum

155

0.90

0.09

1.9

1.7

—

(3004588) Protein electrophoresis panel - Serum or Plasma

126

1.12

0.09

2.4

2.5

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.05

0.08

1.7

1.5

—

(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma

0.82

0.08

4.8

4.5

22.94

26.01

mg/l

—

(3034860) Kappa light chains.free [Mass/volume] in Serum

0.82

0.08

4.8

4.5

33.88

142.08

mg/l

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.83

0.08

1.2

1.5

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.80

0.08

1.0

1.2

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.78

0.08

1.8

1.1

1.62

1.59

g/l

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.05

0.08

1.0

1.4

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.83

0.08

1.5

1.6

727.55

927.73

mu/l

—

(3000764) Benzodiazepines [Presence] in Urine

0.81

0.07

1.0

1.3

—

(3028300) Cannabinoids [Presence] in Urine

0.79

0.07

1.0

1.3

—

(3027944) Amphetamines [Presence] in Urine

0.79

0.07

1.0

1.3

—

(3027008) Opiates [Presence] in Urine

0.79

0.07

1.0

1.3

—

(3020630) Protein [Mass/volume] in Serum or Plasma

147

1.10

0.07

2.4

2.7

65.65

66.73

g/l

0.32

136

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

0.87

0.07

2.1

1.8

11.93

4.09

ug/l

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

315

1.06

0.06

1.2

1.3

19.63

7.03

u/ml

0.30

118

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

174

1725

1.05

0.06

6.1

5.1

1.42

1.48

mmol/l

1.21

160

1598

(3021879) Hepatitis B virus core Ab [Presence] in Serum

131

1.07

0.03

1.2

1.6

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

201

1.05

0.03

1.4

1.5

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

321

1.03

0.02

3.2

3.3

0.71

0.79

ug/l

0.41

217

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

158

0.95

0.02

2.0

1.4

—

(42868678) Cholesterol non HDL [Moles/volume] in Serum or Plasma

154

1.04

0.00

2.1

1.9

3.61

3.43

mmol/l

—

124

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

174

1734

1.02

0.00

6.1

5.2

4.60

4.61

mmol/l

0.06

162

1617

(1761868) Lipid panel - Serum or Plasma

736

0.99

0.00

3.3

—

(3021960) Folate [Moles/volume] in Serum or Plasma

559

1.00

0.00

2.0

1.7

19.80

20.81

nmol/l

0.19

471

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

217

1.02

0.00

3.5

4.8

267.68

245.77

u/l

0.66

209

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

343

0.99

0.00

1.5

1.6

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.06

0.00

2.4

2.0

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.5

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.0

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

3.0

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

1.5

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.5

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

1.5

—

(3024263) Appearance of Synovial fluid

0.00

-0.00

0.0

1.6

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3032567) Hepatitis B virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

2.6

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3020951) Lymphocytes/Leukocytes in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3042847) Granulocytes/Leukocytes in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

0.92

-0.00

2.9

4.5

1.80

1.51

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

1351.50

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(42529528) Centromere protein B Ab [Units/volume] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3028717) Thiamine [Mass/volume] in Blood

0.00

-0.00

0.0

1.4

—

64.40

—

(40760109) Toxoplasma gondii IgG Ab avidity [Ratio] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3033799) Differential panel - Peritoneal fluid

0.00

-0.00

0.0

1.0

—

(3034426) Prothrombin time (PT)

0.00

-0.00

0.0

1.2

—

28.67

—

(42868415) European tick borne encephalitis virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.2

—

(3020229) Cytomegalovirus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.7

—

4.64

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.00

-0.00

2.2

2.0

—

(3037534) Parathyrin related protein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

66.86

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

-0.00

0.0

1.0

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.97

-0.00

1.7

1.6

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.7

—

11.24

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.0

—

129.33

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.87

-0.00

1.4

1.3

—

(3011436) Histone Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_RETINA and mortality.

Females

Parameter	HR [95% CI]	p-value
CD2_BENIGN_RETINA	1.033 [0.85, 1.25]	0.737
Birth year	0.994 [0.98, 1.0]	0.155

During the follow-up period (1.1.1998 — 31.12.2019), 140 out of 738 females with CD2_BENIGN_RETINA died.

Males

Parameter	HR [95% CI]	p-value
CD2_BENIGN_RETINA	0.984 [0.75, 1.29]	0.909
Birth year	0.989 [0.98, 1.0]	0.021

During the follow-up period (1.1.1998 — 31.12.2019), 92 out of 406 males with CD2_BENIGN_RETINA died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_RETINA.

N-year risk	Females	Males
1	0.112%	0.176%
5	0.644%	1.224%
10	1.531%	2.973%
15	2.774%	5.538%
20	4.867%	9.406%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_RETINA – Benign neoplasm: Retina

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm: Retina

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints