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Cerebral atherosclerosis

DOID EFO Endpoint Browser PheWeb

I9_CEREBATHER

cerebral atherosclerosis: Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS.

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Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I67.2
  • Hospital discharge: ICD-9 — 4370
  • Hospital discharge: ICD-8 — 437
  • Cause of death: ICD-10 — I67.2
  • Cause of death: ICD-9 — 4370
  • Cause of death: ICD-8 — 437

2 out of 7 registries used, show all original rules.

613

4. Check minimum number of events

None

613

5. Include endpoints

None

613

6. Filter based on genotype QC (FinnGen only)

536

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I67
Name in latin
Atherosclerosis cerebralis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13448 6688 6394
Only index persons 3338 1814 1524
Unadjusted period prevalence (%)
Whole population 0.19 0.19 0.18
Only index persons 0.06 0.07 0.06
Median age at first event (years)
Whole population 76.04 77.52 74.70
Only index persons 76.30 78.24 74.00

-FinnGen-

Key figures

All Female Male
Number of individuals 536 209 327
Unadjusted period prevalence (%) 0.12 0.07 0.15
Median age at first event (years) 74.26 74.60 74.04

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
549
Matched controls
5474
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I67.2
ICD-10 Finland
Cerebral atherosclerosis
7234.3
307.7
469
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
4.2
43.7
145
432
4370A
ICD-9 Finland
Other and ill-defined cerebrovascular disease, Cerebral atherosclerosis
+∞
43.3
41
*
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
7.3
38.0
59
89
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.5
36.7
166
604
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
8.9
36.4
47
57
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
3.8
33.6
121
377
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
4.1
33.4
105
297
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
6.9
32.5
53
84
AA1AD
NOMESCO Finland
CT of head and brain
2.8
30.2
257
1313
B01AC04
ATC
clopidogrel; oral
2.9
28.7
181
786
PA6AD
NOMESCO Finland
CT of neck arteries
5.2
20.9
45
93
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
4.0
20.7
62
167
43700
ICD-8 Finland
Generalised ischaemic cerebrovascular disease, With hypertension (benign)
+∞
19.9
19
*
43799
ICD-8 Finland
Generalised ischaemic cerebrovascular disease, Without mention of hypertension
+∞
19.9
19
*
XA800
NOMESCO Finland
Neuropsychological investigation
6.3
19.2
33
55
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.6
19.1
69
212
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
7.0
18.8
29
43
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.8
18.0
59
169
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
4.0
16.3
49
132
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
4.4
16.0
41
98
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
4.7
15.6
37
83
PAN14
NOMESCO Finland
Plastic repair of arteries internal carotid artery
13.1
14.0
24
19
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
5.7
13.9
26
47
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.5
13.8
95
417
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
5.5
13.3
26
49
C10AA05
ATC
atorvastatin; oral
1.9
12.2
271
1855
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.1
11.7
52
181
F01.9
ICD-10 Finland
Vascular dementia, unspecified
3.9
11.2
34
92
5541
FHL
Subclavia and / or carotid endarterectomy, reconstruction or bypass surgery
21.9
10.7
15
7
R53
ICD-10 Finland
Malaise and fatigue
1.9
10.5
168
1023
B01AC07
ATC
dipyridamole; systemic
2.4
9.8
71
318
G45.3
ICD-10 Finland
Amaurosis fugax
4.2
9.8
26
64
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.7
9.5
54
215
P76
ICPC
Depressive disorder
4.3
9.2
24
58
N06AX16
ATC
venlafaxine; oral
2.5
9.1
61
263
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
9.0
163
1024
R42
ICD-10 Finland
Dizziness and giddiness
1.8
8.9
154
953
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.8
8.9
206
1392
205
Kela drug reimbursment
Chronic hypertension
1.7
8.8
222
1534
C10AA01
ATC
simvastatin; oral
1.7
8.7
295
2212
K90
ICPC
Stroke/cerebrovascular accident
3.3
8.4
32
101
H53.1
ICD-10 Finland
Subjective visual disturbances
2.9
8.4
39
139
PEF23
NOMESCO Finland
Thrombendarterectomy of femoral artery
4.6
8.4
20
45
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.1
8.4
87
451
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
4.3
8.2
21
50
C10AX09
ATC
ezetimibe; oral
2.0
7.7
96
532
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.6
7.4
42
167
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
7.3
100
572
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.7
7.2
151
983
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.9
7.1
94
531
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.8
6.9
115
699
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
6.9
209
1497
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
3.7
6.8
21
58
A28
ICPC
Limited function/disability NOS
1.7
6.8
149
980
C08CA01
ATC
amlodipine; oral
1.6
6.7
242
1806
R4120
NOMESCO Finland
Occupational therapy
2.5
6.6
40
164
315
Kela drug reimbursment
Clopidogrel
3.9
6.6
19
50
R4130
NOMESCO Finland
Speech therapy
3.6
6.5
21
60
N05AH04
ATC
quetiapine; oral
1.9
6.4
85
479
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.1
6.4
26
86
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.3
6.4
47
212
R51.80
ICD-10 Finland
Headache
2.0
6.3
70
372
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.1
6.2
62
317
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
5.6
6.0
16
29

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
247
1436
2.30
19.80
3.1
2.1
208.75
289.21
u/l
0.60
240
1348
227
1452
1.95
12.65
4.9
4.4
7.40
7.40
ph
0.02
160
1054
131
778
1.89
8.59
2.5
3.1
0.80
0.82
mmol/l
1.05
116
731
279
2124
1.63
7.26
8.2
6.3
1.20
1.21
mmol/l
1.05
264
1929
146
948
1.73
6.97
6.3
4.4
386.50
280.84
ng/l
0.14
134
844
299
2347
1.59
6.63
8.4
7.1
1.20
1.21
mmol/l
0.47
250
1991
25
81
3.18
6.36
1.6
1.2
53.00
1482.68
e6/l
0.54
16
66
124
796
1.71
6.09
3.0
2.5
2.20
2.22
g/l
0.12
109
739
16
29
5.63
6.02
1.3
1.1
—
—
—
0
0
24
79
3.12
5.96
1.5
1.1
4.93
12.05
e6/l
0.36
14
63
319
2600
1.53
5.58
8.3
5.2
7.24
6.88
mmol/l
0.99
305
2496
127
847
1.64
5.35
3.1
2.6
9.92
11.80
umol/l
2.90
113
788
227
1737
1.52
5.24
3.8
3.0
111.00
156.47
ug/l
4.46
210
1576
20
64
3.20
5.21
1.4
1.2
—
—
—
0
0
196
1456
1.53
5.18
2.0
1.8
19.94
20.03
nmol/l
0.03
171
1210
82
495
1.77
4.96
2.5
2.8
7.64
8.79
umol/l
0.21
74
441
113
745
1.65
4.95
3.1
2.6
18.92
21.23
%
1.10
100
694
68
394
1.82
4.71
4.5
3.9
1.23
1.22
mmol/l
0.81
59
331
73
434
1.78
4.65
9.9
7.8
—
—
—
0
0
176
1306
1.51
4.57
3.0
2.3
2.75
3.18
mg/l
1.75
159
1109
290
2377
1.46
4.54
20.3
19.5
1.34
1.38
inr
0.60
250
2004
255
2042
1.46
4.50
2.8
2.3
91.09
92.86
pmol/l
0.27
153
1095
270
2198
1.44
4.30
3.9
3.3
52.16
58.89
u/l
0.50
260
2023
13
30
4.40
4.14
1.2
1.1
—
—
—
0
0
14
35
4.07
4.11
1.9
1.3
24.08
33.31
ng/l
0.38
14
35
137
986
1.51
4.06
1.9
1.8
1058.19
1187.42
nmol/l
1.01
105
738
194
1508
1.44
3.86
5.4
4.6
—
—
—
0
0
254
2075
1.41
3.82
5.8
4.8
33.72
34.32
g/l
0.87
237
1927
25
112
2.28
3.51
1.2
1.3
64.58
62.09
mmol/l
0.10
19
91
196
1553
1.40
3.43
4.2
3.7
—
—
—
0
0
62
387
1.67
3.34
2.6
2.5
28.76
32.54
u/l
0.57
55
313
242
1993
1.38
3.33
6.1
5.4
0.63
0.62
e9/l
0.06
205
1688
236
1939
1.37
3.29
5.9
4.6
91.71
43.12
ng/l
0.64
203
1573
243
2007
1.37
3.27
6.1
5.4
0.04
0.04
e9/l
0.01
206
1702
176
1380
1.40
3.24
6.0
5.3
—
—
—
0
0
275
2321
1.36
3.21
5.7
6.5
12.01
12.56
umol/l
0.23
263
2207
28
137
2.09
3.20
6.8
5.6
1.25
1.42
mmol/l
0.39
22
123
210
1703
1.37
3.14
5.4
4.3
144.73
175.72
e6/l
0.11
144
1264
227
1865
1.36
3.12
6.7
5.6
9.19
9.18
%
0.01
218
1744
227
1866
1.36
3.11
6.6
5.5
2.94
2.77
%
0.53
218
1737
225
1848
1.36
3.09
6.5
5.6
60.24
59.28
%
0.66
220
1751
226
1861
1.36
3.04
6.7
5.6
0.61
0.62
%
0.10
216
1737
228
1881
1.36
3.03
7.0
5.7
25.00
24.98
%
0.01
217
1778
243
2026
1.35
3.01
6.3
5.6
1.68
1.80
e9/l
1.00
207
1770
246
2055
1.35
3.01
6.1
5.6
0.20
0.19
e9/l
0.46
211
1765
192
1558
1.35
2.79
4.5
3.7
84.95
125.41
e6/l
0.31
142
1221
67
447
1.56
2.78
3.9
3.4
213.91
279.49
ng/l
0.67
58
416
79
548
1.51
2.76
4.1
3.7
7.38
7.38
ph
0.18
44
345
167
1329
1.36
2.75
4.3
3.6
0.88
0.51
e6/l
0.54
121
1002
228
1912
1.32
2.62
3.5
3.0
—
—
estimate
—
0
0
74
516
1.50
2.53
2.0
1.8
—
—
—
0
0
134
1045
1.37
2.48
1.9
1.9
445.35
6818624.91
pmol/l
0.50
109
836
12
45
2.70
2.45
1.2
1.3
—
—
nmol/l
—
0
0
13
51
2.58
2.44
1.2
1.4
0.73
37.52
nmol/l
0.49
13
46
317
2804
1.30
2.39
6.2
5.0
—
2.47
—
0
12
75
531
1.47
2.38
3.7
3.7
2.20
1.83
mmol/l
0.34
67
444
5
8
6.28
2.37
1.0
1.0
—
—
—
0
0
54
357
1.56
2.36
6.1
4.2
—
—
—
0
0
65
450
1.50
2.31
2.1
2.1
0.21
0.20
g/l
0.58
59
411
7
18
3.91
2.25
2.1
1.3
—
—
—
0
0
23
121
1.93
2.22
2.3
2.1
120.93
125.62
g/l
0.26
18
91
250
2161
1.28
2.18
5.2
4.5
0.00
0.00
estimate
-0.00
72
490
260
2260
1.28
2.16
7.7
9.0
4.62
4.38
e9/l
0.73
219
1963
252
2182
1.28
2.16
5.2
4.5
0.00
6.87
estimate
0.80
76
510
205
1732
1.29
2.13
4.5
4.0
6.04
6.24
ph
1.66
107
981
32
190
1.72
2.13
1.4
1.3
—
40.04
—
0
17
125
988
1.34
2.11
3.1
3.3
529.10
534.17
mosm/kgh2o
0.10
110
859
317
2831
1.28
2.09
7.2
5.4
14.67
3252.79
e6/l
—
6
66
8
25
3.22
2.09
1.3
1.0
49.40
52.05
mg/l
—
8
19
253
2199
1.27
2.08
5.2
4.5
0.01
0.64
estimate
0.49
71
473
90
677
1.39
2.07
3.0
2.5
1.74
1.79
%
0.18
82
609
10
37
2.73
2.07
1.3
1.3
—
—
—
0
0
51
347
1.51
1.98
5.4
3.7
—
—
—
0
0
138
1116
1.31
1.98
3.6
2.8
4.89
4.47
e6/l
0.23
128
1020
32
195
1.68
1.96
2.3
2.0
556.73
658.03
ug/l
0.12
32
185
5
11
4.56
1.94
2.0
1.3
—
—
—
0
0
24
139
1.75
1.77
1.0
1.2
—
—
—
0
0
83
633
1.36
1.77
9.3
6.3
1.24
1.03
mmol/l
0.23
77
514
208
1796
1.25
1.74
2.8
2.4
78.53
79.40
nmol/l
0.18
192
1572
49
341
1.48
1.73
3.2
3.8
7.41
7.42
ph
0.89
44
283
22
125
1.79
1.73
2.1
3.9
1.67
1.57
index
—
9
70
150
1248
1.27
1.72
3.5
3.2
41.11
37.60
u/l
0.16
138
1186
309
2789
1.24
1.71
4.5
4.1
14.78
15.13
pmol/l
1.76
288
2459
8
31
2.60
1.66
1.0
1.3
—
—
—
0
0
203
1756
1.24
1.65
3.3
3.5
2206.20
2058.20
ng/l
0.14
180
1539
5
14
3.58
1.61
1.0
1.4
152.60
177.57
mmol/24h
—
5
14
82
635
1.34
1.59
9.4
6.3
7.43
7.41
ph
0.88
43
384
14
70
2.02
1.59
1.9
2.7
—
—
—
0
0
55
401
1.41
1.54
2.3
2.0
397.66
392.88
nmol/l
0.05
50
363
198
1724
1.23
1.49
16.5
12.8
0.00
0.00
e9/l
1.06
159
1410
23
139
1.68
1.49
3.4
1.5
2.13
9.44
iu/ml
—
6
38
39
270
1.47
1.44
1.5
1.8
1.62
1.60
g/l
0.05
34
244
9
40
2.26
1.40
1.6
1.7
9.24
10.45
%
—
9
40
99
802
1.28
1.40
4.2
4.8
—
—
—
0
0
95
766
1.29
1.39
4.0
3.5
5.93
2.17
e6/l
0.50
38
406
20
119
1.70
1.38
3.9
3.7
—
—
—
0
0
31
207
1.52
1.37
1.1
1.3
—
—
—
0
0
49
360
1.39
1.34
4.0
4.3
0.00
0.17
%
—
10
112
16
90
1.80
1.33
1.1
1.1
—
—
—
0
0
182
1591
1.21
1.29
3.0
3.4
2.35
2.35
mmol/l
0.16
168
1430
128
1080
1.24
1.29
4.0
3.5
0.00
0.07
—
6
46
5
18
2.79
1.28
1.0
1.1
130.00
138.78
nmol/l
—
5
18
5
18
2.79
1.28
1.0
1.9
0.83
0.84
nmol/l
—
5
13
160
1383
1.22
1.27
3.1
2.6
58.07
119.84
u/l
0.55
155
1287
48
356
1.38
1.25
4.2
4.0
0.00
0.15
%
—
10
121
19
115
1.67
1.25
4.8
4.1
2.57
2.76
mmol/l
0.09
14
77
34
239
1.45
1.20
3.4
3.8
—
—
—
0
0
137
1177
1.21
1.16
5.0
4.0
0.00
0.09
estimate
0.71
57
384
50
379
1.35
1.15
4.1
3.9
0.58
0.88
%
0.44
12
144
12
65
1.86
1.13
1.2
1.2
0.84
0.84
nmol/l
0.01
12
53
84
686
1.26
1.13
1.8
1.4
2.77
2.71
g/l
0.07
44
397
5
21
2.39
1.09
2.0
3.3
84.80
119.90
nmol/l
—
5
21
20
128
1.58
1.08
1.1
1.5
—
—
—
0
0
121
1035
1.21
1.07
2.8
3.1
2.47
2.47
mmol/l
0.02
109
930
108
915
1.22
1.05
1.9
1.7
1.00
1.66
mg/l
4.42
93
744
66
529
1.28
1.04
3.0
2.6
68.40
66.88
e9/l
0.13
51
402
58
457
1.30
1.04
2.4
2.6
4.45
6.72
ug/l
1.10
50
396
299
2769
1.17
1.04
5.9
4.8
—
0.38
—
0
8
5
22
2.28
1.03
1.0
1.0
—
—
—
0
0
18
114
1.59
1.02
2.0
2.5
14.75
74.34
ug/min
—
8
67
60
477
1.29
1.01
2.4
3.0
4.51
4.87
e9/l
0.24
54
402
310
2885
1.16
0.99
37.7
26.0
14.05
14.05
%
0.00
310
2849
0
29
0.00
0.98
0.0
1.2
—
—
—
0
0
57
454
1.28
0.96
1.3
1.3
—
—
—
0
0
46
356
1.31
0.95
3.5
3.8
0.40
0.62
%
—
10
127
332
3113
1.16
0.94
9.0
8.4
80.52
82.95
u/l
0.34
316
2934
89
748
1.22
0.94
1.3
1.2
0.92
1.52
u/ml
0.86
17
192
357
3371
1.16
0.91
6.3
5.3
2.15
2.05
mu/l
0.61
337
2996
72
596
1.24
0.88
1.3
1.3
18.49
38.35
iu/ml
2.02
23
192
10
56
1.79
0.87
1.3
2.1
—
—
—
0
0
56
453
1.26
0.85
1.8
1.3
208.89
473.27
titre
2.65
18
101
28
205
1.38
0.84
2.0
1.9
—
—
—
0
0
13
200
0.64
0.82
1.3
1.3
—
—
—
0
0
0
27
0.00
0.77
0.0
1.2
—
—
—
0
0
0
27
0.00
0.77
0.0
1.2
—
—
—
0
0
0
27
0.00
0.77
0.0
1.6
—
—
—
0
0
26
191
1.38
0.77
2.3
2.1
0.00
0.00
estimate
—
8
52
65
542
1.22
0.76
1.2
1.3
—
—
—
0
0
28
210
1.35
0.74
1.2
1.3
—
—
—
0
0
143
1282
1.15
0.74
5.4
4.6
0.00
0.00
estimate
0.50
64
441
5
25
2.00
0.72
1.2
1.2
75.80
85.08
pmol/l
—
5
25
17
117
1.46
0.71
1.2
1.2
—
—
—
0
0
12
76
1.59
0.71
2.5
2.1
31.92
32.37
pg
0.12
12
76
7
40
1.75
0.71
1.3
1.1
—
—
—
0
0
134
1199
1.15
0.71
7.6
6.3
—
—
—
0
0
160
1454
1.14
0.68
3.6
3.3
7.53
7.07
mmol/l
0.70
137
1191
182
1668
1.13
0.67
5.4
4.6
0.05
0.05
estimate
0.03
63
416
108
956
1.16
0.66
1.4
1.3
—
—
—
0
0
12
78
1.55
0.65
1.5
1.4
—
—
—
0
0
46
378
1.23
0.64
4.9
3.8
90.47
89.47
ng/l
0.03
40
328
164
1501
1.13
0.62
4.4
4.1
11.32
10.05
mg/mmol
0.12
114
944
10
63
1.59
0.61
1.7
1.9
4.36
4.41
mmol/24h
—
10
56
12
80
1.51
0.59
2.8
3.2
—
—
—
0
0
11
72
1.53
0.59
3.9
2.8
3.91
4.83
e9/l
0.76
11
72
8
53
1.51
0.58
1.0
1.0
—
—
u/ml
—
0
0
10
64
1.57
0.58
1.6
2.0
9.51
10.45
mmol/l
—
10
64
118
1064
1.13
0.57
3.0
2.6
—
—
—
0
0
6
37
1.62
0.55
3.3
2.3
—
—
—
0
0
155
1424
1.12
0.55
3.0
2.6
—
—
—
0
0
122
1107
1.13
0.53
3.4
3.0
379.01
362.06
umol/l
0.89
107
941
35
286
1.24
0.53
1.7
1.5
—
—
—
0
0
157
1448
1.11
0.52
3.7
3.4
67.93
56.28
mg/l
0.21
108
961
46
388
1.20
0.52
1.5
2.1
141.55
146.31
ug/g
0.05
40
311
14
100
1.41
0.51
1.0
1.3
—
—
—
0
0
382
3688
1.11
0.50
29.6
20.8
24.87
28.59
mg/l
1.64
356
3192
10
67
1.50
0.49
1.1
1.3
—
—
—
0
0
7
106
0.65
0.49
1.6
1.5
—
—
—
0
0
11
154
0.71
0.48
4.7
5.5
—
—
—
0
0
360
3472
1.10
0.47
8.1
7.4
41.58
40.89
mmol/mol
0.68
344
3180
150
1391
1.10
0.45
2.1
2.0
1.38
1.26
mmol/l
0.62
118
1104
22
175
1.26
0.43
2.0
2.6
718.13
285.23
mg/l
—
8
65
5
31
1.61
0.43
1.8
2.1
—
—
—
0
0
5
31
1.61
0.43
1.2
1.1
—
—
—
0
0
5
32
1.56
0.42
1.2
1.4
—
—
—
0
0
8
58
1.38
0.41
1.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
109351.70
—
0
10
0
17
0.00
0.40
0.0
1.2
—
0.11
—
0
9
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
36
307
1.18
0.38
1.4
1.4
—
—
—
0
0
16
200
0.79
0.35
1.5
1.4
—
—
—
0
0
12
156
0.76
0.35
1.3
3.2
30.07
61.50
u/ml
0.78
12
149
6
44
1.36
0.34
3.7
2.8
3.53
7.50
nmol/l
—
6
44
77
701
1.11
0.34
2.2
2.0
—
—
—
0
0
13
165
0.78
0.33
1.8
3.5
1.83
1.64
mmol/l
0.14
13
159
105
975
1.09
0.32
5.1
4.9
1.02
1.02
kg/l
0.20
75
680
30
257
1.17
0.32
2.4
2.5
—
—
—
0
0
42
370
1.14
0.32
1.3
1.5
—
—
—
0
0
29
248
1.18
0.31
1.2
1.2
—
—
—
0
0
94
1005
0.92
0.29
3.3
3.4
0.84
0.85
ug/l
0.01
74
699
42
373
1.13
0.29
1.3
1.5
—
—
—
0
0
7
57
1.23
0.29
1.1
1.4
—
—
—
0
0
7
57
1.23
0.29
1.1
1.4
—
—
—
0
0
7
57
1.23
0.29
1.1
1.4
—
—
—
0
0
7
57
1.23
0.29
1.1
1.4
—
—
—
0
0
9
119
0.75
0.27
2.1
1.3
—
—
—
0
0
115
1082
1.08
0.26
4.5
3.8
—
—
—
0
0
14
113
1.24
0.26
1.2
1.4
0.25
0.35
mg/l
—
8
46
51
466
1.10
0.23
1.5
1.4
—
—
—
0
0
38
342
1.12
0.22
3.9
2.9
6.10
6.08
ph
0.03
26
258
12
97
1.24
0.22
1.1
1.7
—
—
—
0
0
18
153
1.18
0.22
1.1
1.1
—
—
—
0
0
22
191
1.15
0.21
3.9
2.7
1.72
1.39
mmol/l
0.45
22
186
0
11
0.00
0.21
0.0
1.7
—
2.00
—
0
11
0
11
0.00
0.21
0.0
1.0
—
10.80
—
0
5
38
417
0.90
0.21
2.5
4.1
7.36
7.36
ph
0.00
32
296
19
163
1.17
0.21
3.9
3.1
4.04
4.27
pmol/l
0.44
13
138
5
43
1.16
0.21
2.8
2.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
6
49
1.22
0.20
1.3
1.9
1.16
1.08
g/l
—
6
42
6
50
1.20
0.19
1.0
1.1
—
—
—
0
0
6
52
1.15
0.19
1.3
2.6
2865.33
953.98
mg
—
6
52
20
227
0.87
0.19
3.3
3.1
—
—
—
0
0
336
3292
1.05
0.18
5.6
4.5
1.31
1.25
mmol/l
0.44
323
2919
7
61
1.15
0.17
1.0
1.2
—
—
—
0
0
12
140
0.85
0.16
1.9
3.6
7.08
7.73
mmol/l
0.43
12
134
148
1523
0.96
0.15
2.4
2.3
—
—
—
0
0
6
80
0.75
0.15
1.8
1.4
—
—
—
0
0
374
3682
1.04
0.14
24.9
18.8
—
—
—
0
0
11
93
1.18
0.14
1.0
1.2
—
—
—
0
0
52
549
0.94
0.13
2.7
4.2
10.10
29.92
ug/l
0.67
45
473
8
100
0.79
0.13
1.5
1.8
6.75
14.23
mg/l
—
8
90
57
540
1.06
0.12
1.4
1.4
—
—
—
0
0
388
3829
1.04
0.12
36.8
25.3
139.14
139.54
mmol/l
2.02
383
3746
388
3831
1.03
0.11
37.3
25.6
4.01
4.03
mmol/l
0.52
383
3745
19
173
1.10
0.10
2.1
3.9
1.44
3.14
ratio
—
8
102
11
96
1.15
0.10
4.8
2.8
52.09
60.36
%
1.57
11
96
5
47
1.06
0.09
1.0
1.2
—
—
—
0
0
12
106
1.13
0.09
1.0
1.1
—
—
—
0
0
6
58
1.03
0.08
1.2
1.4
—
—
—
0
0
7
67
1.04
0.08
1.3
1.3
—
—
—
0
0
6
70
0.85
0.07
1.0
1.1
—
—
—
0
0
9
84
1.07
0.07
5.3
2.7
18.67
10.53
pmol/l
—
9
84
9
84
1.07
0.07
1.7
1.8
43.11
44.50
nmol/l
—
9
78
377
3779
0.98
0.05
15.3
13.0
24.91
24.50
u/l
0.18
368
3644
389
3861
1.02
0.04
37.8
27.8
87.08
86.76
umol/l
0.05
384
3800
39
401
0.97
0.04
2.2
2.1
0.40
0.00
estimate
—
10
72
358
3552
1.01
0.04
7.7
6.3
2.18
2.48
mmol/l
8.99
348
3185
173
1740
0.99
0.03
5.6
6.0
2.50
3.94
ug/l
1.13
155
1530
286
2836
1.01
0.03
39.8
27.6
330.48
330.53
g/l
0.03
281
2814
161
1618
0.99
0.02
5.1
4.2
—
0.71
—
0
7
346
3461
0.99
0.02
6.6
5.4
4.03
4.36
mmol/l
7.51
333
3117
54
547
0.98
0.01
1.4
1.3
1.41
14.05
u/ml
3.23
16
187
343
3427
0.99
0.00
6.5
5.3
1.39
1.44
mmol/l
1.28
328
3062
33
335
0.98
0.00
1.5
1.5
—
—
—
0
0
14
143
0.98
0.00
2.2
3.5
1.30
0.88
nmol/l
—
9
120
30
297
1.01
0.00
1.8
2.4
12.87
12.66
nmol/l
0.05
25
259
10
95
1.05
0.00
1.0
1.2
—
63.75
—
0
8
30
294
1.02
0.00
1.5
1.5
—
—
—
0
0
389
3876
1.00
0.00
42.6
30.9
7.16
7.03
e9/l
0.57
377
3766
13
128
1.01
0.00
25.1
12.2
—
—
—
0
0
388
3874
1.00
0.00
43.8
31.4
38.37
39.17
%
1.65
383
3810
388
3874
1.00
0.00
42.5
30.8
30.40
30.45
pg
0.21
383
3812
388
3874
1.00
0.00
42.7
30.9
4.30
4.34
e12/l
0.91
376
3766
388
3874
1.00
0.00
42.7
30.9
242.28
236.18
e9/l
0.94
376
3782
388
3873
1.00
0.00
42.5
30.8
91.83
91.99
fl
0.27
383
3812
355
3542
1.00
0.00
6.5
5.7
6.28
6.16
mmol/l
0.89
332
3148
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
69.33
—
0
6
0
8
0.00
-0.00
0.0
1.4
—
41.88
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
6.76
—
0
8
0
7
0.00
-0.00
0.0
1.7
—
0.56
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
0.05
—
0
6
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
5
58
0.86
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
19.58
—
0
6
5
59
0.84
-0.00
1.2
2.6
—
—
—
0
0
7
78
0.89
-0.00
10.1
3.3
1.00
1.71
%
—
7
70
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
6
59
1.01
-0.00
1.2
1.1
—
—
—
0
0
9
99
0.90
-0.00
1.1
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint I9_CEREBATHER and mortality.

Females

Parameter HR [95% CI] p-value
I9_CEREBATHER 2.047 [1.71, 2.45] < 0.001
Birth year 0.993 [0.98, 1.0] 0.133

During the follow-up period (1.1.1998 — 31.12.2019), 756 out of 1228 females with I9_CEREBATHER died.

Males

Parameter HR [95% CI] p-value
I9_CEREBATHER 2.466 [1.9, 3.21] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 656 out of 1080 males with I9_CEREBATHER died.

Mortality risk

Mortality risk for people of age

years, who have I9_CEREBATHER.

N-year risk Females Males
1 0.185% 0.353%
5 1.028% 2.747%
10 2.745% 6.72%
15 5.394% 11.925%
20 9.426% 19.076%

Relationships between endpoints

↥

Index endpoint: I9_CEREBATHER – Cerebral atherosclerosis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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