Felty's syndrome: Felty syndrome (FS), also known as ''super rheumatoid'' disease, is a severe form of rheumatoid arthritis (RA), characterized by a triad of RA, splenomegaly and neutropenia, resulting in susceptibility to bacterial infections.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
214 |
4. Check minimum number of eventsNone |
214 |
5. Include endpointsNone |
214 |
6. Filter based on genotype QC (FinnGen only) |
196 |
Control definitions (FinnGen only)
- Control exclude
- RHEUMA_SEROPOS
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M05
- Name in latin
- Syndroma Felty
Similar endpoints
↥List of similar endpoints to
Felty syndrome
based on the number of shared cases.
Similar with more cases:
- Seropositive rheumatoid arthritis
- Finngen Rheumatological endpoints
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2047 | 1446 | 568 |
| Only index persons | 1398 | 1042 | 356 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.02 |
| Only index persons | 0.03 | 0.04 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 66.27 | 66.71 | 64.83 |
| Only index persons | 62.81 | 63.27 | 61.45 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 196 | 143 | 53 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.02 |
| Median age at first event (years) | 59.58 | 58.82 | 61.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 201
- Matched controls
- 2010
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M05.0
ICD-10 Finland
Felty syndrome
+∞
271.6
194
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
159.6
268.5
174
78
P01BA02
ATC
hydroxychloroquine; oral
65.4
201.8
135
61
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
1559.0
199.3
162
5
L04AX03
ATC
methotrexate; systemic
50.1
178.5
128
68
A07EC01
ATC
sulfasalazine; oral, rectal
50.3
167.6
113
50
L88
ICPC
Rheumatoid/seropositive arthritis
87.7
156.6
86
17
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
120.2
154.3
80
11
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
40.5
142.4
100
48
L01BA01
ATC
methotrexate; systemic
386.6
127.2
116
7
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
44.5
125.0
81
30
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
1843.8
110.3
97
*
L04AA13
ATC
[U] leflunomide
378.8
77.3
73
*
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
+∞
74.7
67
*
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
123.9
58.8
61
7
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
30.0
56.3
39
16
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
107.2
52.0
55
7
M01CB01
ATC
sodium aurothiomalate; parenteral
+∞
50.1
46
*
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
603.8
49.6
47
*
L04AB01
ATC
etanercept; parenteral
538.0
45.1
43
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
8.9
38.9
58
88
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
7.9
34.1
56
94
H02AB06
ATC
prednisolone; systemic
7.5
33.0
164
749
L04AB04
ATC
adalimumab; parenteral
63.0
28.1
32
6
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
9.1
25.5
34
44
M05BA04
ATC
alendronic acid; oral
5.7
25.4
58
133
H02AB07
ATC
prednisone; oral
5.1
23.9
64
168
M05
ICD-10 Finland
Seropositive rheumatoid arthritis
258.2
23.1
23
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.4
23.0
135
634
R4120
NOMESCO Finland
Occupational therapy
7.1
22.1
37
62
L04AX01
ATC
azathioprine; systemic
18.5
21.5
33
21
71239
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD
67.7
21.4
24
*
L04AA01
ATC
[U] ciclosporin
47.3
21.0
25
6
M01CB03
ATC
auranofin; oral
220.8
19.9
20
*
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
9.1
19.2
25
31
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
26.9
19.2
26
11
D06BB04
ATC
podophyllotoxin; topical
8.8
18.7
25
32
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.8
18.2
37
75
ZX120
NOMESCO Finland
Intravenous
4.8
17.6
46
116
M01AH01
ATC
celecoxib; oral
3.8
16.7
70
250
H02AB04
ATC
methylprednisolone; systemic
4.0
16.6
59
188
NH3EA
NOMESCO Finland
Feet X-ray examination with load
33.2
16.5
21
7
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
33.2
16.5
21
7
M05BA07
ATC
risedronic acid; oral
7.4
16.2
25
38
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
65.5
16.0
18
*
NDG30
NOMESCO Finland
Fusion of wrist, total
65.5
16.0
18
*
M06
ICD-10 Finland
Other rheumatoid arthritis
+∞
15.8
15
*
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
172.9
15.7
16
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.2
15.0
48
141
XX9XE
NOMESCO Finland
Other ultrasound examination
86.6
14.8
16
*
L04AB05
ATC
certolizumab pegol; parenteral
+∞
14.8
14
*
9256
FHL
Synovectomy (knee 9311)
+∞
14.8
14
*
L04AA17
ATC
[U] adalimumab
+∞
14.8
14
*
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
21.1
14.6
21
11
TPH04
NOMESCO Finland
Cathetrisation of vein
3.4
14.4
72
285
7140B
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SERONEGATIVA]
80.8
13.8
15
*
TNG10
NOMESCO Finland
Puncture of knee
36.9
13.7
17
5
L01CB
ATC
Podophyllotoxin derivatives
+∞
13.7
13
*
L04AB06
ATC
golimumab; parenteral
+∞
13.7
13
*
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
23.1
13.6
19
9
M06.8
ICD-10 Finland
Other specified rheumatoid arthritis
43.2
13.4
16
*
NDL52
NOMESCO Finland
Tenosynovectomy of hand
43.2
13.4
16
*
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
74.7
12.8
14
*
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
21.8
12.7
18
9
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
+∞
12.6
12
*
L04AA11
ATC
[U] etanercept
+∞
12.6
12
*
NDB60
NOMESCO Finland
Prosthetic replacement of MCP joint of finger
+∞
12.6
12
*
L04AA24
ATC
abatacept; parenteral
138.3
12.6
13
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
17.3
12.4
19
12
D70.89
ICD-10 Finland
Neutropenic splenomegaly
17.8
11.9
18
11
NDG76
NOMESCO Finland
Fusion of DIP joint
32.2
11.8
15
5
J01FF01
ATC
clindamycin; systemic
2.9
11.8
78
357
L04AC07
ATC
tocilizumab; parenteral
+∞
11.6
11
*
M05BX04
ATC
denosumab; parenteral
4.2
11.4
33
89
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
4.9
11.4
27
62
M81.9
ICD-10 Finland
Osteoporosis, unspecified
4.6
10.8
28
69
N02AX02
ATC
tramadol; systemic, rectal
2.7
10.8
113
649
M19.2
ICD-10 Finland
Other secondary arthrosis
17.2
10.5
16
10
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
115.8
10.5
11
*
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
5.2
10.3
22
46
NH1AE
NOMESCO Finland
Ankle joint ultrasound examination
42.3
10.1
12
*
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
4.9
9.8
23
52
B01AB04
ATC
dalteparin; parenteral
5.0
9.8
22
48
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.0
9.8
22
48
H02AB08
ATC
triamcinolone; systemic
57.9
9.7
11
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
9.7
82
418
TQW40
NOMESCO Finland
Remowal of suture of skin
4.2
9.7
28
75
7148X
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Other specified inflammatory polyarthropathies
104.8
9.5
10
*
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
10.3
9.5
18
19
NG1DA
NOMESCO Finland
X-ray of knees
11.5
9.5
17
16
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.5
9.3
35
113
1XC02, ,
NOMESCO Finland
38.6
9.1
11
*
9503
FHL
Tendon or tendon sheath cleansing surgery (tenosynovectomy)
38.6
9.1
11
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.7
9.1
32
99
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.0
8.9
48
193
WX320
NOMESCO Finland
Spinalanesthesy
2.6
8.9
71
350
ZXA00
NOMESCO Finland
Right side
2.5
8.8
81
427
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
5.1
8.8
19
40
M01AH02
ATC
rofecoxib; oral
3.0
8.8
45
176
ZXX01
NOMESCO Finland
Extent of proceudre, 1 unit
28.9
8.6
11
*
J01MA12
ATC
levofloxacin; systemic
2.7
8.6
58
263
RT271, ,
NOMESCO Finland
93.8
8.5
9
*
NDM99
NOMESCO Finland
Other operation on fascia, ganglion, synovial sheath or bursa of wrist or hand
93.8
8.5
9
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
8.4
119
756
NDB78
NOMESCO Finland
Prosthetic replacement of several of finger or metacarpal
+∞
8.4
8
*
TNB10
NOMESCO Finland
Joint puncture, shoulder joint
+∞
8.4
8
*
3006
Kela drug reimbursment
Baricitinib
+∞
8.4
8
*
M01CC01
ATC
penicillamine; oral
+∞
8.4
8
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.5
8.4
31
99
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
10.7
8.2
15
15
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.2
8.1
36
129
L04AD01
ATC
ciclosporin; systemic
11.5
7.9
14
13
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
11.5
7.9
14
13
ZXA05
NOMESCO Finland
Left side
2.4
7.8
73
384
TND10
NOMESCO Finland
Joint puncture, wrist or finger joint
46.8
7.8
9
*
9272
FHL
Metatarsophalangeal joint resection
46.8
7.8
9
*
NHM20
NOMESCO Finland
Excision of synovial ganglion of ankle or foot
12.5
7.7
13
11
NK4AT
NOMESCO Finland
Puncture of joint with ultrasound guidance not elsewher classified
19.3
7.7
11
6
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.3
7.5
20
50
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
83.0
7.5
8
*
Z3231
NOMESCO Finland
Registered nurse
2.4
7.4
74
399
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
9.9
7.4
14
15
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
4.6
7.4
18
42
9271
FHL
Hallux surgery
7.8
7.3
16
22
9527
FHL
Alloarthroplasty, implant or endoprosthesis
+∞
7.3
7
*
NCB20
NOMESCO Finland
Primary total prosthetic replacement of elbow joint
+∞
7.3
7
*
293
Kela drug reimbursment
Baricitinib
+∞
7.3
7
*
NDF10
NOMESCO Finland
Synovectomy of wrist
+∞
7.3
7
*
TNH10
NOMESCO Finland
Joint puncture, ankle joint or foot joint
+∞
7.3
7
*
M08.8
ICD-10 Finland
Other juvenile arthritis
+∞
7.3
7
*
NHG24
NOMESCO Finland
Fusion of subtalar joint and between bones of ankle
31.2
7.2
9
*
ZX140
NOMESCO Finland
Intra articular
31.2
7.2
9
*
NHG22
NOMESCO Finland
Fusion of subtalar joint
31.2
7.2
9
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.0
7.2
36
138
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
4.5
7.2
18
43
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
4.4
7.0
18
44
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
6.5
6.9
17
28
M45
ICD-10 Finland
Ankylosing spondylitis
9.8
6.9
13
14
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
6.8
59
298
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
6.3
6.8
17
29
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
4.4
6.7
17
41
M01AB55
ATC
diclofenac, combinations; oral
3.3
6.6
26
86
M05BA06
ATC
ibandronic acid; systemic
6.6
6.6
16
26
Z3226
NOMESCO Finland
Physiotherapist
2.4
6.5
52
252
N02BA01
ATC
acetylsalicylic acid; systemic, rectal
72.0
6.5
7
*
NDG74
NOMESCO Finland
Fusion of first IP joint
72.0
6.5
7
*
71200
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Juvenile rheumatoid arthritis
72.0
6.5
7
*
5BA08, ,
NOMESCO Finland
72.0
6.5
7
*
TNC11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in elbow joint
72.0
6.5
7
*
M05BB03
ATC
alendronic acid and colecalciferol; oral
5.4
6.4
18
36
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
7.4
6.3
14
20
M05.3
ICD-10 Finland
Rheumatoid arthritis with involvement of other organs and systems
+∞
6.3
6
*
9531
FHL
Arthrodesis of the hand joint
+∞
6.3
6
*
NDG77
NOMESCO Finland
Other excision, reconstruction or fusion of joint of first finger
+∞
6.3
6
*
L04AA37
ATC
[U] baricitinib
+∞
6.3
6
*
7143C
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Juvenile chronic polyarthritis[POLYARTHRITIS JUVENILIS SERONEGATIVA]
+∞
6.3
6
*
RT171, ,
NOMESCO Finland
+∞
6.3
6
*
9289
FHL
Other measure in this category
+∞
6.3
6
*
NK6PA
NOMESCO Finland
Measurement of bone density from one location with X-ray
27.6
6.3
8
*
R50.9
ICD-10 Finland
Fever, unspecified
2.6
6.2
40
175
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.8
6.2
34
137
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
13.1
6.1
10
8
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
3.4
6.1
23
74
S97
ICPC
Chronic ulcer skin
3.2
6.1
25
85
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.9
6.1
18
49
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
35
35
11.90
31.86
2.4
1.2
—
—
—
0
0
33
37
10.47
27.62
3.5
1.4
7937.96
19663.61
e6/l
0.51
24
23
33
41
9.43
25.53
1.6
1.6
0.01
0.04
iu/ml
—
9
9
153
982
3.34
12.54
22.7
9.6
4.10
4.01
e9/l
0.22
147
847
19
40
5.14
8.79
2.2
1.6
—
—
—
0
0
60
279
2.64
8.41
1.4
1.3
106.62
2.32
u/ml
4.85
28
103
36
141
2.89
6.91
2.2
1.8
—
—
—
0
0
60
308
2.35
6.64
1.3
1.3
136.27
24.09
iu/ml
4.16
44
95
12
12
10.55
6.63
1.1
1.3
—
—
—
0
0
121
826
2.17
6.57
3.2
2.6
81.45
79.95
nmol/l
0.26
115
731
133
950
2.18
6.33
7.0
4.3
0.00
16.68
estimate
0.80
36
210
131
941
2.13
6.00
7.0
4.2
0.00
0.00
estimate
-0.00
35
201
60
323
2.22
5.85
2.5
1.9
—
—
—
0
0
131
958
2.06
5.50
7.0
4.3
0.00
0.00
estimate
-0.00
34
191
131
966
2.02
5.28
10.1
6.8
1.21
1.22
mmol/l
0.66
120
827
14
30
4.93
4.78
1.2
1.1
—
—
—
0
0
47
248
2.17
4.73
1.8
1.8
—
—
—
0
0
8
8
10.35
4.56
1.9
2.5
—
—
—
0
0
18
61
3.14
4.41
1.6
4.6
1.55
3.80
ratio
0.86
12
33
18
61
3.14
4.41
3.2
2.5
—
—
—
0
0
14
43
3.42
3.99
2.1
1.5
—
—
—
0
0
43
234
2.07
3.96
1.8
1.9
—
—
—
0
0
32
159
2.20
3.70
1.9
3.1
63.64
66.53
g/l
1.14
32
145
133
1568
0.55
3.69
6.6
7.0
38.65
39.87
mmol/mol
0.91
127
1453
13
35
3.90
3.67
1.0
1.3
—
—
—
0
0
13
35
3.90
3.67
1.0
1.3
—
—
—
0
0
22
95
2.48
3.48
13.3
6.8
14.65
15.60
%
0.66
22
90
11
27
4.25
3.45
1.4
1.6
—
—
—
0
0
9
18
5.18
3.41
1.4
1.4
—
—
—
0
0
6
7
8.79
3.28
1.2
1.6
—
—
—
0
0
143
1639
0.56
3.27
5.6
6.2
2.45
2.65
mmol/l
1.98
136
1491
112
861
1.68
3.23
7.8
5.9
1.20
1.22
mmol/l
0.98
106
782
13
40
3.40
3.20
1.3
1.6
—
—
—
0
0
21
96
2.33
2.95
11.4
4.4
1.51
1.45
%
0.19
21
90
11
32
3.58
2.95
1.4
1.7
—
—
—
0
0
109
847
1.63
2.90
7.4
4.5
33.40
35.30
g/l
2.50
103
794
7
13
5.53
2.89
5.3
5.6
0.79
0.62
%
—
7
13
141
1605
0.59
2.75
5.1
5.3
4.51
4.63
mmol/l
0.66
135
1461
140
1594
0.60
2.69
4.8
5.2
1.57
1.52
mmol/l
0.56
134
1440
11
37
3.08
2.53
1.3
1.6
—
—
—
0
0
13
51
2.66
2.50
2.8
3.4
1.13
1.37
index
—
8
30
30
171
1.89
2.41
3.0
2.3
0.21
0.21
g/l
0.07
30
158
68
489
1.59
2.39
3.3
2.2
3.19
3.07
mg/l
0.18
62
416
143
1605
0.62
2.29
4.8
5.6
5.72
6.02
mmol/l
2.63
132
1458
5
9
5.66
2.22
4.4
1.9
—
—
—
0
0
5
9
5.66
2.22
4.6
1.9
—
—
—
0
0
5
9
5.66
2.22
4.6
1.9
—
—
—
0
0
5
9
5.66
2.22
4.6
1.9
—
—
—
0
0
8
24
3.43
2.20
3.5
2.4
12.00
10.29
mmol/l
—
8
24
5
10
5.10
2.08
1.6
4.3
73.20
104.70
nmol/l
—
5
10
17
83
2.15
2.08
1.7
2.2
6.89
7.54
g/l
0.93
17
78
17
83
2.15
2.08
1.7
2.2
4.68
4.24
g/l
0.62
17
78
17
83
2.15
2.08
1.7
2.2
4.02
3.91
g/l
0.06
17
78
11
44
2.59
2.05
1.3
1.2
—
—
—
0
0
15
70
2.24
2.04
1.4
1.3
—
—
—
0
0
68
508
1.51
1.97
6.7
3.6
0.00
0.00
estimate
-0.00
28
158
32
199
1.72
1.95
4.3
3.5
2.58
2.14
mmol/l
0.33
27
173
6
16
3.83
1.95
6.2
2.2
—
—
—
0
0
135
1519
0.66
1.95
4.4
4.4
1.34
1.27
mmol/l
0.56
127
1362
7
22
3.26
1.89
1.7
1.1
—
—
—
0
0
86
680
1.46
1.86
3.6
3.4
2.33
2.37
mmol/l
1.87
80
621
76
588
1.47
1.84
2.6
2.5
65.24
64.02
u/l
0.04
70
543
79
620
1.45
1.76
4.1
3.5
1900.06
1350.41
ng/l
0.70
72
532
6
18
3.40
1.76
6.2
2.1
—
—
—
0
0
11
48
2.37
1.74
1.7
1.6
107.33
128.89
g/l
—
6
35
12
55
2.26
1.71
1.2
1.9
—
—
—
0
0
13
62
2.17
1.69
2.5
1.8
—
—
—
0
0
20
113
1.85
1.67
4.2
2.8
4.78
5.10
kpa
0.73
20
107
11
49
2.32
1.67
4.3
1.7
—
—
—
0
0
11
49
2.32
1.67
2.7
1.6
—
—
—
0
0
5
14
3.63
1.62
1.0
1.5
—
—
—
0
0
5
14
3.63
1.62
4.4
2.1
—
—
—
0
0
5
14
3.63
1.62
1.0
1.5
—
—
—
0
0
5
14
3.63
1.62
4.4
2.1
—
—
—
0
0
5
14
3.63
1.62
4.4
2.1
—
—
—
0
0
15
79
1.97
1.54
1.5
2.2
2.63
3.07
g/l
0.98
15
74
11
51
2.22
1.53
2.0
1.6
—
—
—
0
0
7
27
2.65
1.53
1.6
1.3
—
—
—
0
0
14
73
1.99
1.48
1.6
2.6
0.67
0.36
g/l
0.28
14
66
70
553
1.41
1.46
7.6
4.3
0.00
0.00
estimate
-0.00
33
188
41
295
1.49
1.40
4.0
3.4
2.43
3.47
e6/l
0.48
23
134
5
17
2.99
1.36
1.0
1.1
—
—
—
0
0
38
272
1.49
1.33
4.4
6.4
103.97
103.96
mmol/l
0.00
38
272
6
24
2.54
1.31
1.5
1.2
186.00
283.25
u/ml
—
6
12
14
77
1.88
1.29
1.5
2.0
9.46
10.09
g/l
0.33
14
71
9
44
2.09
1.28
1.4
1.4
—
—
—
0
0
85
710
1.34
1.23
7.6
4.3
0.00
0.01
estimate
0.50
31
159
18
111
1.68
1.16
1.9
2.5
1.24
1.13
%
0.28
18
111
18
111
1.68
1.16
1.9
2.4
0.71
0.61
%
0.90
18
111
8
39
2.09
1.16
1.9
1.3
—
—
—
0
0
52
407
1.37
1.13
1.3
1.2
0.65
0.99
u/ml
0.81
12
110
25
170
1.54
1.11
3.6
2.6
0.08
0.92
e6/l
0.93
25
157
8
41
1.99
1.10
1.0
1.4
—
—
—
0
0
5
21
2.41
1.09
1.2
1.1
—
—
—
0
0
144
1555
0.74
1.09
6.8
5.8
2.03
1.94
mu/l
0.40
138
1423
12
67
1.84
1.07
4.4
2.0
—
—
—
0
0
5
22
2.30
1.04
1.0
1.6
13.72
16.47
ug/l
—
5
22
18
117
1.59
0.97
2.1
1.9
—
—
—
0
0
46
363
1.35
0.95
5.2
3.8
604.97
173.77
ng/l
0.53
39
296
14
216
0.62
0.92
9.1
8.2
—
—
—
0
0
11
63
1.79
0.92
1.7
2.1
6828.36
382.45
ug/l
0.45
11
58
90
782
1.27
0.92
4.6
3.1
258.51
115.07
ug/l
0.66
85
720
30
222
1.41
0.90
10.1
6.6
0.31
1.12
mmol/l
0.65
25
187
63
525
1.29
0.89
4.4
3.4
0.34
0.42
e6/l
0.19
50
377
6
31
1.96
0.85
3.2
2.5
1.18
1.19
mmol/l
—
6
31
6
31
1.96
0.85
3.2
2.5
107.33
106.06
mmol/l
—
6
31
123
1338
0.79
0.84
6.1
4.6
15.64
15.14
pmol/l
1.28
117
1211
22
156
1.46
0.83
2.5
4.0
1.25
1.23
mmol/l
1.19
22
135
53
436
1.29
0.82
2.8
3.1
337.56
340.53
umol/l
0.07
48
373
0
24
0.00
0.79
0.0
4.2
—
85.38
—
0
24
0
25
0.00
0.79
0.0
1.4
—
911.70
—
0
20
101
901
1.24
0.79
3.2
2.8
—
—
—
0
0
7
38
1.87
0.74
1.0
1.4
—
—
—
0
0
16
109
1.51
0.73
4.7
6.8
24.90
24.98
mmol/l
0.02
16
109
40
324
1.29
0.70
4.0
3.2
0.96
1.31
e6/l
0.53
23
160
50
420
1.25
0.66
8.4
4.7
1.02
1.02
kg/l
0.05
40
284
83
739
1.21
0.63
5.9
4.4
43.28
146.37
ng/l
0.66
60
563
89
799
1.20
0.62
4.2
2.9
—
—
estimate
—
0
0
49
415
1.24
0.60
2.2
1.8
439.67
432.69
pmol/l
0.08
43
343
6
35
1.74
0.58
1.2
2.1
8.92
6.49
pmol/l
—
6
35
24
186
1.33
0.58
3.3
3.5
—
—
—
0
0
6
36
1.69
0.57
6.0
1.8
—
—
—
0
0
30
241
1.29
0.56
1.6
1.5
—
—
—
0
0
9
60
1.52
0.55
4.3
3.6
24.10
25.01
mmol/l
—
9
55
18
139
1.32
0.45
2.0
1.5
—
—
—
0
0
10
69
1.47
0.45
1.7
2.2
0.00
0.00
g/l
—
10
64
42
362
1.20
0.44
1.9
1.8
1011.54
1217.55
nmol/l
0.98
29
264
6
92
0.64
0.43
1.8
1.6
—
—
—
0
0
8
57
1.42
0.42
1.6
1.4
—
—
—
0
0
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
168
1627
1.20
0.38
43.4
17.5
20.97
24.44
mg/l
1.13
163
1356
9
71
1.28
0.36
1.7
2.1
0.00
0.00
g/l
—
9
62
16
127
1.28
0.34
14.3
6.2
21.36
24.66
mmol/l
1.55
16
122
7
100
0.69
0.31
2.0
1.7
—
—
—
0
0
7
56
1.26
0.29
1.3
1.1
—
—
—
0
0
22
258
0.83
0.29
5.1
5.1
18.65
23.20
%
0.94
13
135
7
57
1.24
0.29
1.3
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
5.6
—
1074.40
—
0
10
0
10
0.00
0.21
0.0
1.5
—
54.94
—
0
10
0
12
0.00
0.21
0.0
1.4
—
0.96
—
0
6
0
12
0.00
0.21
0.0
1.6
—
50.65
—
0
12
0
12
0.00
0.21
0.0
1.4
—
1.10
—
0
6
0
12
0.00
0.21
0.0
1.4
—
1.39
—
0
6
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
13
110
1.19
0.17
1.6
1.4
—
—
—
0
0
108
1043
1.08
0.17
4.2
3.1
54.32
48.26
u/l
0.26
102
962
10
82
1.23
0.17
1.2
1.3
—
—
—
0
0
153
1561
0.92
0.17
29.6
17.8
77.66
75.13
ml/min/173m2
0.77
148
1464
7
85
0.82
0.15
1.0
1.0
—
—
—
0
0
63
601
1.07
0.14
2.6
1.8
21.36
21.51
nmol/l
0.03
57
498
59
617
0.94
0.12
4.1
4.0
7.86
6.74
mg/mmol
0.15
45
370
44
417
1.07
0.11
4.2
2.5
—
—
—
0
0
24
223
1.09
0.09
4.0
3.9
6.47
10.02
ug/l
0.47
19
191
42
439
0.95
0.08
2.9
2.8
2.46
2.47
mmol/l
0.15
35
401
88
859
1.04
0.08
2.6
2.3
103.32
97.64
pmol/l
0.42
50
419
29
281
1.04
0.02
2.4
1.9
29.59
28.93
s
0.32
29
270
13
138
0.94
0.02
2.2
3.1
72.00
61.77
ml/min/173m2
—
8
61
28
288
0.97
0.02
1.9
1.4
—
—
—
0
0
13
131
0.99
0.00
6.9
7.6
1.28
1.38
%
0.12
13
131
10
103
0.97
0.00
1.5
1.2
158.40
140.90
u/ml
—
5
41
13
128
1.02
0.00
6.9
7.6
0.50
0.68
%
1.02
13
128
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
0.00
0.0
1.0
—
139.17
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
7
0.00
-0.00
0.0
2.6
—
119.00
—
0
7
0
9
0.00
-0.00
0.0
6.2
—
226.11
—
0
9
0
9
0.00
-0.00
0.0
1.9
—
10.03
—
0
9
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
7.30
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
4.51
—
0
9
5
53
0.94
-0.00
2.0
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint FELTY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FELTY | 2.656 [2.3, 3.06] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.553 |
During the follow-up period (1.1.1998 — 31.12.2019), 536 out of 1102 females with FELTY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FELTY | 2.379 [1.86, 3.04] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 414 males with FELTY died.
Mortality risk
Mortality risk for people of age
years, who have FELTY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.245% | 0.413% |
| 5 | 1.675% | 2.536% |
| 10 | 4.164% | 6.464% |
| 15 | 7.829% | 11.817% |
| 20 | 13.78% | 19.08% |
Relationships between endpoints
↥Index endpoint: FELTY – Felty syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data