corneal disease: A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma.
Other and unspecified corneal deformities and disorders
DOID EFO Endpoint Browser PheWeb
H7_CORNEALNAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1426 |
4. Check minimum number of eventsNone |
1426 |
5. Include endpointsNone |
1426 |
6. Filter based on genotype QC (FinnGen only) |
1269 |
Control definitions (FinnGen only)
- Control exclude
- H7_SCLERACORNEA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF6
Similar endpoints
↥List of similar endpoints to
Other and unspecified corneal deformities and disorders
based on the number of shared cases.
Similar with more cases:
- Other disorders of cornea
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8787 | 4685 | 4066 |
| Only index persons | 8268 | 4439 | 3829 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.13 | 0.11 |
| Only index persons | 0.16 | 0.16 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 46.79 | 50.05 | 42.97 |
| Only index persons | 46.07 | 49.15 | 42.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1269 | 761 | 508 |
| Unadjusted period prevalence (%) | 0.26 | 0.27 | 0.23 |
| Median age at first event (years) | 50.89 | 50.78 | 51.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1323
- Matched controls
- 13230
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H16.0
ICD-10 Finland
Corneal ulcer
76.1
307.7
450
89
H18.8
ICD-10 Finland
Other specified disorders of cornea
8594.2
307.7
962
*
CG2T4
NOMESCO Finland
Topography assessment of cornea
117.4
268.8
137
13
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
6.5
223.0
978
3997
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
+∞
182.6
171
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.8
182.4
341
642
S01AD03
ATC
aciclovir; ophthalmic
13.2
169.1
169
145
H16.9
ICD-10 Finland
Keratitis, unspecified
292.2
155.0
155
6
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
425.0
154.6
152
*
H18.7
ICD-10 Finland
Other corneal deformities
1618.7
150.0
143
*
CGD10
NOMESCO Finland
Laser keratoplasty for error of refraction
49.6
128.9
75
16
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
118.6
112
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
169.3
118.5
123
8
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
135.8
105.8
112
9
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.4
101.6
314
883
H18.6
ICD-10 Finland
Keratoconus
532.0
101.0
99
*
H04.10
ICD-10 Finland
Dry eye syndrome
4.3
97.9
308
876
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
3.2
91.9
612
2811
H18.4
ICD-10 Finland
Corneal degeneration
323.9
90.0
90
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.4
83.4
241
638
S01ED01
ATC
timolol; ophthalmic
8.6
83.3
111
140
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
23.7
81.5
59
26
WX100
NOMESCO Finland
Conjunctival surface anesthesia
3.9
78.5
271
815
3718X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Other corneal disorders
+∞
74.7
71
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
74.7
71
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.2
74.0
374
1433
S05.0
ICD-10 Finland
Injury of conjunctiva and corneal abrasion without mention of foreign body
9.3
72.8
90
103
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
154.4
69.7
73
5
H57.1
ICD-10 Finland
Ocular pain
6.5
68.7
118
197
XCK10
NOMESCO Finland
Photography of fundus of eye
3.9
62.6
206
594
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
626.1
61.3
60
*
WX140
NOMESCO Finland
Parabulbar anesthesy
5.4
60.6
126
252
S01AA01
ATC
chloramphenicol; ophthalmic
5.1
59.6
132
279
TCG10
NOMESCO Finland
Removal of sutures from cornea
112.0
59.4
64
6
S01EA05
ATC
brimonidine; ophthalmic
8.3
56.7
76
96
CG2S4
NOMESCO Finland
Photography of cornea
125.6
56.3
60
5
S01ED51
ATC
timolol, combinations; ophthalmic
4.1
52.3
157
422
H18.1
ICD-10 Finland
Bullous keratopathy
517.0
50.8
50
*
H17.8
ICD-10 Finland
Other corneal scars and opacities
517.0
50.8
50
*
3604
FHL
Penetration of the cornea
+∞
50.3
48
*
S01BA07
ATC
fluorometholone; ophthalmic
8.7
48.4
62
74
H16.2
ICD-10 Finland
Keratoconjunctivitis
165.9
46.1
48
*
S01BC03
ATC
diclofenac; ophthalmic
7.4
46.1
68
96
Z3229
NOMESCO Finland
Other healthcare associate professional
3.5
44.7
168
525
S01BA04
ATC
prednisolone; ophthalmic
9.1
44.3
55
63
S01XA18
ATC
ciclosporin; ophthalmic
13.1
43.6
42
33
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
42.9
41
*
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
15.8
42.7
37
24
H16.8
ICD-10 Finland
Other keratitis
222.0
42.1
43
*
S01EC01
ATC
acetazolamide; systemic
7.8
41.8
59
79
S01BA01
ATC
dexamethasone; ophthalmic
5.3
39.8
82
162
S01EA03
ATC
apraclonidine; ophthalmic
13.0
39.3
38
30
H25.1
ICD-10 Finland
Senile nuclear cataract
2.3
38.9
387
2003
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
38.7
37
*
CGE10
NOMESCO Finland
Keratectomy
+∞
37.7
36
*
CGG11
NOMESCO Finland
Corneal cross-linking
+∞
37.7
36
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.2
36.6
434
2405
F01
ICPC
Eye pain
5.2
34.9
73
146
XCH00
NOMESCO Finland
Eye pressure measurement
4.1
34.6
100
260
3619
FHL
Other operations in this group, such as corneal refractive surgery
+∞
34.5
33
*
ZXA10
NOMESCO Finland
Bilateral
2.4
34.2
287
1370
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.2
33.1
143
485
H3603, E103,
ICD-10 Finland
10.0
32.2
37
38
114
Kela drug reimbursment
Glaucoma
3.1
32.0
145
505
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
324.6
32.0
32
*
H26.4
ICD-10 Finland
After-cataract
2.9
31.9
169
643
XCK00
NOMESCO Finland
Perimetry
3.6
31.6
111
330
3716A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Keratoconus
+∞
31.4
30
*
H18.2
ICD-10 Finland
Other corneal oedema
+∞
31.4
30
*
ZXA05
NOMESCO Finland
Left side
2.2
31.3
367
2004
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.3
30.7
123
398
H52.2
ICD-10 Finland
Astigmatism
5.9
30.5
56
99
S01EE01
ATC
latanoprost; ophthalmic
3.4
28.5
108
337
A10AA01, ,
ATC
4.7
27.3
65
145
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
5.2
27.0
56
111
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
26.1
25
*
H26.2
ICD-10 Finland
Complicated cataract
7.8
26.0
36
47
S01EC04
ATC
brinzolamide; ophthalmic
4.0
25.9
75
195
A10AB01
ATC
insulin (human); parenteral
4.0
25.8
76
200
L04AA01
ATC
[U] ciclosporin
8.3
25.7
34
42
CG2Z4
NOMESCO Finland
Specialised imaging of cornea
254.8
24.7
25
*
F29
ICPC
Eye symptom/complaint other
2.5
24.4
177
783
H19.1
ICD-10 Finland
Herpesviral keratitis and keratoconjunctivitis
244.2
23.7
24
*
ZXA00
NOMESCO Finland
Right side
1.9
23.1
370
2225
Z3231
NOMESCO Finland
Registered nurse
1.9
23.0
374
2259
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
23.0
22
*
A10AA02, ,
ATC
4.0
22.8
67
176
WX002
NOMESCO Finland
Sedation and analgesia
2.0
22.7
279
1530
S01FA01
ATC
atropine; ophthalmic
32.9
22.5
29
9
H40.0
ICD-10 Finland
Glaucoma suspect
2.6
22.1
132
532
H26.02
ICD-10 Finland
Presenil cataract
4.2
21.4
57
139
S01EX03, ,
ATC
5.7
21.4
40
72
H01.80
ICD-10 Finland
Prolonged inflammation in the edge of the eyelid
7.7
21.3
30
40
H04AA01
ATC
glucagon; nasal, parenteral
4.7
20.4
47
102
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
4.0
20.1
57
146
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
3.3
19.4
74
232
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
31.8
19.3
25
8
S01AX11
ATC
[U] ofloxacin
3.7
19.3
61
169
H16.1
ICD-10 Finland
Other superficial keratitis without conjunctivitis
70.9
18.7
21
*
S01FA04
ATC
cyclopentolate; ophthalmic
14.4
18.6
31
22
CD2S4
NOMESCO Finland
Photography of eye
14.6
18.1
30
21
S01GX01
ATC
cromoglicic acid; ophthalmic
1.9
18.0
295
1768
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
6.8
17.9
28
42
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
182.3
17.6
18
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
7.5
17.4
25
34
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
2.5
17.4
114
480
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
5.9
17.2
31
54
9881
FHL
Bandage replacement, suture or spike removal, or the like in an operating room or anesthesia
50.7
17.0
20
*
H15.1
ICD-10 Finland
Episcleritis
16.6
16.6
26
16
CGF10
NOMESCO Finland
Suture of laceration of cornea
172.1
16.5
17
*
A10AB04
ATC
insulin lispro; parenteral
3.3
16.2
61
190
S01BC05
ATC
ketorolac; ophthalmic
3.4
16.1
58
175
H43.1
ICD-10 Finland
Vitreous haemorrhage
4.1
16.0
44
110
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
3.0
16.0
71
244
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
4.1
15.8
44
111
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
2.5
15.7
107
458
H16.4
ICD-10 Finland
Corneal neovascularization
+∞
15.7
15
*
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
161.8
15.5
16
*
S01EE05
ATC
tafluprost; ophthalmic
3.2
15.5
61
195
127
Kela drug reimbursment
Transplant complication
5.0
15.3
33
68
H33.0
ICD-10 Finland
Retinal detachment with retinal break
3.5
15.1
51
148
T89
ICPC
Diabetes insulin dependent
2.9
15.0
72
258
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
2.9
15.0
71
253
S01EC03
ATC
dorzolamide; ophthalmic
5.8
15.0
27
47
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
14.8
480
3447
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
3.8
14.7
45
122
3710A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Corneal scars and opacities
+∞
14.6
14
*
H18.0
ICD-10 Finland
Corneal pigmentations and deposits
+∞
14.6
14
*
H18.3
ICD-10 Finland
Changes in corneal membranes
151.6
14.5
15
*
CFD10
NOMESCO Finland
Repair of conjunctiva
36.5
14.5
18
5
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.9
14.3
185
1021
S01AA12
ATC
tobramycin; ophthalmic
27.5
14.3
19
7
H52.1
ICD-10 Finland
Myopia
3.0
13.9
63
219
37103
ICD-8 Finland
Corneal opacity, Keratoconus
+∞
13.6
13
*
CGW99
NOMESCO Finland
Other operation on cornea or sclera
+∞
13.6
13
*
ZXD20
NOMESCO Finland
Day surgery
1.9
13.5
180
1002
CGD99
NOMESCO Finland
Other operation for error of refraction
141.4
13.5
14
*
S01FA02
ATC
scopolamine; ophthalmic
14.2
12.8
21
15
S01KA02
ATC
hypromellose; ophthalmic
4.3
12.7
33
79
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
17.5
12.5
19
11
CGF35
NOMESCO Finland
Repair of cornea using graft
+∞
12.5
12
*
H16.3
ICD-10 Finland
Interstitial and deep keratitis
+∞
12.5
12
*
H02AB06
ATC
prednisolone; systemic
1.5
12.2
602
4695
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
8.8
12.0
25
29
H11.0
ICD-10 Finland
Pterygium
8.8
12.0
25
29
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
5.7
12.0
22
39
H36.00
ICD-10 Finland
Diabetic background retinopathy
4.9
11.9
26
54
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
47.1
11.9
14
*
E10
ICD-10 Finland
Type 1 diabetes mellitus
3.8
11.8
35
93
D07AC01
ATC
betamethasone; topical
1.5
11.7
460
3408
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
11.6
566
4386
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
3.8
11.6
35
94
H15.0
ICD-10 Finland
Scleritis
+∞
11.5
11
*
3700A
ICD-9 Finland
Keratitis, Corneal ulcer
+∞
11.5
11
*
H54.1
ICD-10 Finland
Severe visual impairment, binocular
121.0
11.4
12
*
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
121.0
11.4
12
*
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
3.0
11.2
50
173
H27.0
ICD-10 Finland
Aphakia
15.6
10.8
17
11
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
5.6
10.7
20
36
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.6
10.7
306
2104
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
10.5
565
4441
J05AB11
ATC
valaciclovir; oral
1.7
10.5
192
1176
CBH25
NOMESCO Finland
Tarsorrhaphy
110.9
10.4
11
*
ZZL00
NOMESCO Finland
Free graft of amniotic membrane
110.9
10.4
11
*
E85.80
ICD-10 Finland
Meretoja sick
+∞
10.4
10
*
H19.8*E85.80
ICD-10 Finland
Reticular keratitis in Meretoja's patients
+∞
10.4
10
*
H21.0
ICD-10 Finland
Hyphaema
+∞
10.4
10
*
36400
ICD-8 Finland
Iritis, Iridocyclitis acuta
+∞
10.4
10
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
10.4
231
1490
A10AC01
ATC
insulin (human); parenteral
2.1
10.4
103
516
H19.2*B02.3
ICD-10 Finland
Keratitis and keratoconjunctivitis (interstitial) in zoster
32.8
10.3
13
*
A10AE04
ATC
insulin glargine; parenteral
1.9
10.3
129
702
S01EE03
ATC
bimatoprost; ophthalmic
3.4
10.3
37
112
H53.1
ICD-10 Finland
Subjective visual disturbances
2.1
10.2
99
492
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
3.3
10.2
37
113
UJF32
NOMESCO Finland
Coloscopy
1.6
10.1
314
2196
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
2.1
10.1
94
460
A10AE06
ATC
insulin degludec; parenteral
2.6
10.0
58
231
CKC12
NOMESCO Finland
Photocoagulation of retina
2.5
10.0
60
243
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
16.8
9.9
15
9
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
26.2
9.8
13
5
ZXE00
NOMESCO Finland
One hour or less
1.5
9.6
465
3564
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
4.3
9.6
24
56
S01EB01
ATC
pilocarpine; ophthalmic
9.2
9.5
19
21
F02
ICPC
Red eye
2.5
9.5
58
237
37100
ICD-8 Finland
Corneal opacity, Cicatrix (nubecula, macula, leucoma) cornea
+∞
9.4
9
*
T85.3
ICD-10 Finland
Mechanical complication of other ocular prosthetic devices, implants and grafts
+∞
9.4
9
*
CGE16
NOMESCO Finland
Destruction of lesion of cornea
+∞
9.4
9
*
N03AX16
ATC
[U] pregabalin
1.6
9.4
283
1964
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
4.0
9.3
26
66
J01AA02
ATC
doxycycline; systemic
1.5
9.3
992
8799
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
9.1
354
2592
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
5.1
9.1
19
38
L17
ICPC
Foot/toe symptom/complaint
1.5
9.0
380
2826
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
9.0
445
3415
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
3.5
8.9
30
87
A10AB05
ATC
insulin aspart; parenteral
2.0
8.8
98
512
S01XA02
ATC
retinol; ophthalmic
10.8
8.8
16
15
H25.0
ICD-10 Finland
Senile incipient cataract
2.1
8.7
79
383
H01.0
ICD-10 Finland
Blepharitis
2.0
8.7
96
501
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.0
8.5
93
483
H20.8
ICD-10 Finland
Other iridocyclitis
90.6
8.4
9
*
CHB15
NOMESCO Finland
Puncture of anterior chamber of eye with replacement of aqueous
90.6
8.4
9
*
H53.9
ICD-10 Finland
Visual disturbance, unspecified
2.4
8.4
55
232
H40.9
ICD-10 Finland
Glaucoma, unspecified
3.5
8.4
28
81
S01EE51
ATC
latanoprost and netarsudil; ophthalmic
12.8
8.4
14
11
H17.0
ICD-10 Finland
Adherent leukoma
+∞
8.3
8
*
37108
ICD-8 Finland
Corneal opacity, Alia definita
+∞
8.3
8
*
3606
FHL
Keratophakic corneal surgery
+∞
8.3
8
*
3719
FHL
Other measure in this category
+∞
8.3
8
*
CBH30
NOMESCO Finland
Tarsorraphy
+∞
8.3
8
*
F05
ICPC
Visual disturbance other
2.6
8.3
47
185
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
2.6
8.2
46
180
H3601, E103,
ICD-10 Finland
6.5
8.2
20
31
H10.2
ICD-10 Finland
Other acute conjunctivitis
3.5
8.1
27
78
J01DB01
ATC
cefalexin; oral
1.5
8.1
1051
9523
Z97.0
ICD-10 Finland
Presence of artificial eye
33.6
8.1
10
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
8.1
421
3250
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
10.1
8.0
15
15
M79.6
ICD-10 Finland
Pain in limb
1.4
8.0
554
4495
L04AD01
ATC
ciclosporin; systemic
3.5
8.0
27
79
E0000UV, ,
ATC
1.4
8.0
504
4025
XCW10
NOMESCO Finland
Assessment of vision
3.7
7.9
24
65
J01MA02
ATC
ciprofloxacin; systemic
1.4
7.9
456
3583
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
4.7
7.9
18
39
103
Kela drug reimbursment
Diabetes, insulin-treated
1.5
7.9
312
2285
J01FF01
ATC
clindamycin; systemic
1.5
7.8
330
2445
S01EE04
ATC
travoprost; ophthalmic
3.4
7.8
27
80
H11.1
ICD-10 Finland
Conjunctival degenerations and deposits
9.5
7.8
15
16
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.1
7.8
32
106
H25.8
ICD-10 Finland
Other senile cataract
1.8
7.7
113
647
CGE55
NOMESCO Finland
Excision of pterygium with transplanation of conjunctiva
15.1
7.7
12
8
H54.0
ICD-10 Finland
Blindness, binocular
45.2
7.7
9
*
S01EC54
ATC
brinzolamide, combinations; ophthalmic
4.4
7.7
19
44
A10AE05
ATC
insulin detemir; parenteral
2.1
7.7
68
327
R4110
NOMESCO Finland
Physiotherapy
1.5
7.7
333
2481
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
8.1
7.6
16
20
E000001, ,
ATC
1.5
7.5
231
1602
R51.80
ICD-10 Finland
Headache
1.6
7.5
199
1337
D07AB08
ATC
desonide; topical
1.7
7.5
131
792
S05.2
ICD-10 Finland
Ocular laceration and rupture with prolapse or loss of intraocular tissue
80.5
7.4
8
*
CBG00
NOMESCO Finland
Epilation of cilia by electrolysis
13.4
7.4
12
9
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.6
7.3
159
1017
36399
ICD-8 Finland
Keratitis, Without mention of ulcer
+∞
7.3
7
*
37403
ICD-8 Finland
Cataract, Complicata
+∞
7.3
7
*
CGD40
NOMESCO Finland
Implantation of intracorneal ring segments
+∞
7.3
7
*
36402
ICD-8 Finland
Iritis, Iridocyclitis, uveitis chronica
+∞
7.3
7
*
3656X
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA SECUNDARIA ALIA SEU NUD]
+∞
7.3
7
*
3719X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Unspecified corneal disorder
+∞
7.3
7
*
3714A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Corneal degenerations
+∞
7.3
7
*
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
4.2
7.3
19
46
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
3.4
7.3
25
74
TCC40
NOMESCO Finland
Closure of lacrimal canaliculus with plug
15.8
7.2
11
7
Z2221
NOMESCO Finland
Medical doctor
1.4
7.2
319
2384
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
7.2
297
2190
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
20.1
7.1
10
5
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.6
7.0
183
1223
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.8
7.0
99
561
A07AA02
ATC
nystatin; oral
2.0
7.0
72
367
A02BC05
ATC
esomeprazole; systemic
1.4
7.0
491
3971
J02AC01
ATC
fluconazole; systemic
1.4
6.9
476
3833
H3600, E103,
ICD-10 Finland
4.0
6.9
19
48
XCD10
NOMESCO Finland
Electrophysiological examination of eye
3.0
6.9
30
103
S01AX12
ATC
[U] norfloxacin
8.3
6.8
14
17
S01GX09
ATC
olopatadine; ophthalmic
2.6
6.8
39
155
J01FA10
ATC
azithromycin; systemic
1.4
6.8
701
6008
M03BX02
ATC
tizanidine; oral
1.4
6.8
782
6816
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
1.9
6.8
81
435
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
40.3
6.8
8
*
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
40.3
6.8
8
*
R42
ICD-10 Finland
Dizziness and giddiness
1.5
6.7
268
1961
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
22.6
6.7
9
*
L01BA01
ATC
methotrexate; systemic
2.4
6.7
43
181
S01EA02
ATC
dipivefrine; ophthalmic
12.3
6.6
11
9
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
12.3
6.6
11
9
A10AD01
ATC
insulin (human); parenteral
3.3
6.6
24
74
H27.1
ICD-10 Finland
Dislocation of lens
10.1
6.5
12
12
D06BX01
ATC
metronidazole; topical
1.7
6.5
133
837
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
6.2
6.5
16
26
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
5.7
6.5
17
30
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
3.5
6.4
21
60
M94.0
ICD-10 Finland
Chondrocostal junction syndrome [Tietze]
2.8
6.4
30
107
3642
FHL
Anterior vitrectomy
70.2
6.4
7
*
H3602, E103,
ICD-10 Finland
14.4
6.4
10
7
N02BE01
ATC
paracetamol; systemic, rectal
1.5
6.4
1138
10615
L04AX03
ATC
methotrexate; systemic
1.7
6.3
112
679
WX142
NOMESCO Finland
Sub-tenon anesthesy
5.5
6.3
17
31
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
1.8
6.3
91
520
CHC05
NOMESCO Finland
Iridotomy
3.5
6.3
21
61
R07.4
ICD-10 Finland
Chest pain, unspecified
1.4
6.3
331
2542
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.7
6.3
122
759
CGG30
NOMESCO Finland
Anterior lamellar transplantation of cornea
+∞
6.3
6
*
3641A
ICD-9 Finland
Disorders of iris and ciliary body, Chronic iridocyclitis
+∞
6.3
6
*
QAJ20
NOMESCO Finland
Subperiosteal facelift
+∞
6.3
6
*
H44.0
ICD-10 Finland
Purulent endophthalmitis
26.8
6.2
8
*
3643
FHL
Vitrectomy through pars Plana
26.8
6.2
8
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.6
6.2
159
1058
N05BB01
ATC
hydroxyzine; systemic
1.9
6.2
75
405
F03
ICPC
Eye discharge
1.9
6.2
82
456
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
3.4
6.2
21
62
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
2.7
6.1
32
122
B00.5
ICD-10 Finland
Herpesviral ocular disease
12.6
6.1
10
8
H54.4
ICD-10 Finland
Blindness, monocular
12.6
6.1
10
8
S01AA02
ATC
chlortetracycline; ophthalmic
6.7
6.0
14
21
S01ED02
ATC
betaxolol; ophthalmic
5.2
6.0
17
33
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
55
114
4.99
25.22
1.4
1.3
—
—
—
0
0
33
61
5.52
17.18
1.6
1.2
—
—
—
0
0
1007
8846
1.58
11.07
8.9
8.2
77.11
78.84
u/l
0.65
966
8452
1220
11296
2.03
10.95
18.7
15.2
21.69
23.36
mg/l
1.18
1022
9276
739
6097
1.48
10.87
4.1
3.8
0.01
6.62
estimate
1.58
141
1260
521
4031
1.48
10.49
3.8
3.4
7.81
7.68
mmol/l
0.26
456
3466
443
3325
1.50
10.33
3.2
2.9
0.00
0.03
0.49
13
62
497
3824
1.48
10.22
4.7
4.1
7.90
8.73
mg/mmol
0.14
331
2378
738
6151
1.45
9.88
4.1
3.8
0.02
0.27
estimate
0.47
128
1171
1235
11555
2.03
9.65
22.3
17.8
3.97
3.97
mmol/l
0.36
1216
11321
628
5095
1.44
9.61
6.1
5.1
36.27
35.95
g/l
0.91
595
4801
724
6034
1.44
9.55
4.1
3.8
0.00
0.00
estimate
0.50
140
1232
1232
11532
1.99
9.38
22.0
17.7
139.72
139.69
mmol/l
0.16
1212
11324
966
8528
1.49
9.25
4.8
4.2
12.37
11.67
mm/h
0.74
915
8027
653
5378
1.42
8.98
2.9
2.5
78.15
76.61
nmol/l
0.73
606
4906
786
6704
1.42
8.80
10.3
9.7
4.07
4.06
e9/l
0.04
697
5870
849
7353
1.43
8.65
5.2
4.6
1152.93
1948.73
e6/l
0.43
14
101
783
6725
1.40
8.09
5.9
5.1
6.82
6.65
mmol/l
1.48
749
6400
1268
12085
2.18
7.71
24.0
19.6
77.85
75.66
umol/l
1.68
1260
11967
1145
10608
1.59
7.58
6.2
5.4
1.89
1.88
mu/l
0.12
1083
9914
1053
9590
1.48
7.49
23.5
18.8
13.62
13.58
%
0.38
1041
9467
997
9045
1.42
6.73
5.0
4.4
14.71
14.69
pmol/l
0.09
929
8401
446
3568
1.38
6.70
2.3
2.2
134.07
225.65
u/l
2.61
429
3404
460
3701
1.37
6.66
3.1
2.7
57.27
60.00
u/l
0.38
426
3457
500
4084
1.36
6.56
3.5
3.3
35.51
32.45
u/l
0.17
483
3871
352
2717
1.40
6.53
4.2
3.9
1.02
1.02
kg/l
0.01
250
1806
267
1968
1.45
6.39
3.4
2.9
0.94
1.13
e6/l
0.50
158
1034
120
740
1.68
6.36
3.6
3.6
4.50
4.57
pmol/l
0.17
104
665
1055
9702
1.43
6.31
25.4
19.4
332.37
332.56
g/l
0.30
1048
9655
601
5069
1.34
6.31
2.3
2.1
95.32
97.00
pmol/l
0.38
324
2675
374
2931
1.38
6.30
2.7
2.2
2.68
2.87
mg/l
0.90
336
2537
399
3163
1.37
6.26
3.9
3.2
0.31
0.42
e6/l
0.67
317
2312
1256
12013
1.90
6.25
14.0
11.9
26.26
26.65
u/l
0.40
1236
11735
245
1784
1.46
6.24
1.6
1.7
1184.76
1179.44
nmol/l
0.03
189
1353
291
2194
1.42
6.13
5.1
3.8
213.88
518.45
ng/l
1.90
231
1661
140
909
1.60
6.06
4.2
3.9
88.24
86.21
ng/l
0.10
124
803
1155
10838
1.52
5.94
7.6
6.1
40.61
39.02
mmol/mol
6.28
1111
10241
450
3663
1.35
5.89
4.0
3.3
66.02
75.21
e6/l
0.10
367
2801
603
5141
1.32
5.67
13.1
13.3
1.21
1.21
inr
0.07
507
4264
192
1371
1.47
5.38
3.4
2.8
7.51
7.78
umol/l
0.06
164
1215
827
7398
1.31
5.34
3.1
3.1
—
—
—
0
0
37
162
2.32
5.31
1.1
1.1
—
—
—
0
0
242
1808
1.41
5.31
3.7
3.0
3.59
2.79
e6/l
0.24
133
870
123
800
1.59
5.30
3.5
2.9
185.28
195.89
ng/l
0.06
115
728
17
50
3.43
5.03
1.6
3.3
729.88
719.78
u/ml
0.02
17
50
637
5536
1.29
4.95
3.7
3.1
104.44
121.28
ug/l
1.78
603
5219
82
491
1.71
4.89
1.2
1.2
1.37
1.68
u/ml
—
7
31
109
704
1.60
4.85
7.6
7.0
25.00
24.57
mmol/l
0.66
104
676
64
366
1.79
4.49
1.5
1.3
—
—
—
0
0
1277
12387
1.89
4.44
29.1
23.6
40.27
40.57
%
1.22
1266
12270
398
3289
1.30
4.44
3.2
3.2
1153.21
1112.51
ng/l
0.09
359
2787
540
4641
1.28
4.43
4.0
3.7
0.04
0.04
estimate
0.10
114
1000
654
5757
1.27
4.39
8.9
7.2
1.22
1.21
mmol/l
0.85
572
5001
1276
12381
1.86
4.33
28.8
23.2
253.15
252.92
e9/l
0.04
1254
12173
1276
12384
1.85
4.28
28.6
23.1
91.04
90.99
fl
0.13
1266
12276
336
2729
1.31
4.24
1.8
1.7
1.28
1.15
mg/l
0.17
257
2105
1276
12387
1.85
4.24
28.7
23.2
4.49
4.51
e12/l
1.25
1247
12148
1276
12388
1.85
4.22
28.7
23.2
6.75
6.68
e9/l
0.35
1251
12143
1276
12393
1.83
4.14
28.9
23.4
135.02
135.96
g/l
1.49
1265
12285
311
2509
1.31
4.11
3.0
2.7
4.45
6.09
e6/l
2.01
294
2302
178
1318
1.41
4.09
7.5
8.2
1.14
0.95
mmol/l
0.25
144
1105
342
2797
1.30
4.08
1.5
1.3
2.47
1.41
u/ml
0.37
100
793
68
408
1.70
4.07
1.8
2.2
227.27
371.17
ug/l
0.55
63
386
302
2430
1.31
4.06
1.6
1.5
2.46
2.44
g/l
0.06
197
1537
291
2341
1.31
3.91
1.4
1.3
117.26
28.52
iu/ml
0.43
105
708
65
391
1.70
3.86
2.0
2.5
10.30
10.45
g/l
0.11
60
354
888
8173
1.26
3.83
3.4
3.4
44.76
47.99
u/l
0.75
848
7748
1202
11537
1.46
3.82
6.6
5.7
2.70
2.76
mmol/l
1.38
1144
10843
686
6138
1.24
3.78
6.9
6.7
10.53
11.42
umol/l
1.43
654
5882
469
4029
1.25
3.70
3.5
3.5
2.35
2.35
mmol/l
0.09
432
3681
202
1553
1.35
3.69
7.0
5.8
1.05
1.03
mmol/l
0.43
181
1436
55
323
1.73
3.58
1.3
1.1
3.03
3.46
—
9
44
229
1810
1.32
3.47
3.0
2.5
2.31
2.34
g/l
0.29
212
1689
584
5168
1.23
3.45
7.7
6.6
1.21
1.21
mmol/l
0.34
546
4791
76
491
1.58
3.45
3.1
3.2
25.25
25.40
mmol/l
0.12
68
475
267
2158
1.30
3.44
1.3
1.3
10.13
11.52
u/ml
0.11
99
839
385
3258
1.26
3.41
1.8
1.7
22.26
20.46
nmol/l
0.99
334
2786
279
2270
1.29
3.41
3.0
2.9
2.45
2.45
mmol/l
0.21
250
2046
360
3023
1.26
3.41
2.8
2.7
340.39
339.19
umol/l
0.08
327
2705
129
934
1.42
3.38
2.6
3.1
67.40
67.12
g/l
0.17
121
866
157
1178
1.38
3.35
8.0
8.6
96.03
95.53
%
0.61
149
1144
185
1425
1.35
3.34
2.0
1.8
—
—
—
0
0
564
4987
1.23
3.32
2.1
1.9
1.39
1.39
mmol/l
0.00
492
4304
72
1081
0.65
3.25
1.8
1.7
3.49
3.50
mmol/l
0.03
56
786
286
2348
1.28
3.25
1.8
1.7
465.50
30975664.15
pmol/l
2.15
251
1979
1185
11396
1.38
3.23
5.9
5.1
4.62
4.70
mmol/l
1.65
1134
10749
77
509
1.54
3.18
1.9
2.1
38.19
39.19
u/l
0.17
71
450
499
4373
1.23
3.17
3.8
3.6
36.20
60.09
ng/l
0.79
354
2999
176
1358
1.34
3.15
2.1
1.9
—
—
—
0
0
241
1950
1.29
3.06
3.1
2.5
13.34
13.36
umol/l
0.02
225
1823
245
1987
1.29
3.06
4.4
3.3
0.82
0.82
mmol/l
0.07
231
1885
1180
11356
1.36
3.06
5.7
5.0
1.44
1.47
mmol/l
1.54
1125
10652
171
1330
1.33
2.90
7.8
8.2
5.11
5.11
kpa
0.02
162
1285
171
1330
1.33
2.90
7.8
8.2
12.13
12.24
kpa
0.12
163
1288
259
2129
1.27
2.90
1.8
1.5
—
—
—
0
0
7
13
5.41
2.87
4.4
5.2
5.04
5.59
mmol/l
—
7
13
107
1450
0.71
2.83
2.0
2.0
3.55
3.51
ratio
0.11
92
1155
110
806
1.40
2.73
2.3
2.5
14.92
19.36
au/ml
—
9
86
1143
10989
1.29
2.66
17.3
14.6
81.95
82.67
ml/min/173m2
0.55
1083
10184
84
592
1.45
2.60
1.1
1.1
—
0.92
—
0
5
54
347
1.58
2.57
2.1
2.4
0.03
0.01
g/l
0.16
49
313
20
94
2.14
2.55
1.2
1.1
—
—
—
0
0
192
1547
1.28
2.53
2.4
2.4
146.01
121.29
ug/g
0.36
152
1241
122
925
1.35
2.48
3.8
2.6
57.74
66.87
ml/min/173m2
2.08
58
391
205
1673
1.27
2.43
3.1
2.5
23.48
23.11
%
0.15
195
1570
56
369
1.54
2.41
1.2
1.3
303.79
222.03
miu/ml
0.73
16
181
49
313
1.59
2.41
5.1
3.3
1.64
2.01
index
0.23
25
163
20
97
2.08
2.38
1.2
1.1
—
—
—
0
0
20
97
2.08
2.38
1.2
1.1
—
—
—
0
0
21
104
2.04
2.37
1.1
1.1
—
—
—
0
0
52
340
1.55
2.33
2.1
2.5
0.00
0.00
g/l
-0.00
46
294
228
1896
1.24
2.31
2.0
1.9
—
—
—
0
0
54
357
1.53
2.30
1.6
1.6
0.23
0.24
g/l
0.18
54
340
34
200
1.72
2.30
1.6
1.6
—
—
—
0
0
100
745
1.37
2.29
1.3
1.3
22.80
48.25
au/ml
—
6
52
344
2987
1.20
2.28
4.6
4.1
91.61
91.66
%
0.01
337
2923
129
1002
1.32
2.25
2.1
2.4
13.37
13.34
nmol/l
0.02
115
924
380
3335
1.20
2.24
3.3
3.2
0.00
0.06
estimate
1.36
100
973
84
611
1.40
2.22
1.5
1.5
—
—
—
0
0
68
476
1.45
2.22
1.6
1.9
1.68
1.48
g/l
0.90
58
420
55
369
1.51
2.21
1.6
1.6
1.24
1.21
g/l
0.37
55
349
19
94
2.04
2.16
1.2
1.1
—
—
—
0
0
131
1028
1.30
2.13
9.1
7.4
9.23
9.09
mmol/l
0.08
122
992
61
422
1.47
2.12
1.8
1.7
—
—
—
0
0
52
348
1.51
2.12
2.1
2.3
3555.47
3750.51
u/l
0.03
20
132
72
516
1.42
2.08
1.4
1.8
4.13
7.37
iu/ml
0.85
12
118
48
317
1.53
2.08
1.2
1.2
—
—
—
0
0
36
222
1.64
2.07
1.2
1.1
2.97
19.41
au/ml
—
10
66
111
855
1.33
2.07
1.7
1.3
497.58
192.33
u/ml
0.66
105
793
40
254
1.59
2.05
5.5
5.7
1288.86
300.80
iu/ml
—
7
35
14
63
2.24
2.01
1.1
1.1
—
—
—
0
0
9
32
2.82
2.00
1.3
3.5
10.03
10.35
kpa
—
9
32
9
32
2.82
2.00
1.3
3.5
4.82
4.97
kpa
—
9
32
46
304
1.53
2.00
1.9
1.7
—
—
—
0
0
30
178
1.70
2.00
1.0
1.1
3.06
2.36
—
5
31
5
11
4.56
1.94
1.2
1.6
—
—
—
0
0
22
120
1.85
1.93
1.2
1.8
—
—
—
0
0
140
1125
1.27
1.92
3.3
2.6
30.16
42.41
u/l
1.86
123
946
16
79
2.04
1.85
2.1
1.8
—
—
—
0
0
47
318
1.50
1.85
1.2
1.2
—
—
—
0
0
138
1112
1.27
1.85
5.0
3.6
1.98
1.85
mmol/l
0.21
119
964
21
115
1.84
1.83
1.1
1.2
—
—
—
0
0
120
952
1.29
1.83
3.0
2.7
10.77
10.76
g/l
0.01
113
881
23
131
1.77
1.78
1.2
1.7
—
—
—
0
0
1119
10841
1.21
1.73
4.9
4.3
1.31
1.31
mmol/l
0.01
1053
10081
19
103
1.86
1.72
8.3
3.5
9.63
12.60
index
—
8
68
90
694
1.32
1.70
2.3
2.0
—
—
—
0
0
15
75
2.01
1.70
1.4
2.0
537.60
636.38
e6/l
—
10
63
31
195
1.60
1.69
1.5
1.3
—
—
—
0
0
40
268
1.51
1.67
1.6
2.2
137.60
129.26
g/l
1.57
30
212
10
40
2.51
1.66
1.0
1.4
—
—
—
0
0
116
929
1.27
1.66
2.3
2.4
1.16
0.60
e6/l
0.44
111
891
105
831
1.29
1.65
1.7
1.6
—
—
—
0
0
40
270
1.50
1.62
2.9
2.9
1.37
1.54
mmol/l
0.72
40
263
583
5403
1.14
1.61
3.2
2.8
—
—
estimate
—
0
0
34
222
1.55
1.60
3.0
3.0
6.64
7.51
mmol/l
1.31
34
216
15
77
1.96
1.59
2.4
2.0
—
—
—
0
0
12
235
0.51
1.58
1.4
1.5
1.15
1.17
ratio
—
6
145
12
235
0.51
1.58
1.4
1.5
0.75
0.94
ratio
—
6
145
12
235
0.51
1.58
1.4
1.5
1.86
1.16
ratio
—
6
145
22
129
1.72
1.57
1.5
1.6
57.27
53.75
ug/l
0.16
22
129
55
398
1.40
1.57
2.1
2.6
0.58
1.09
g/l
0.65
50
350
12
234
0.51
1.56
1.3
1.5
—
—
—
0
0
24
145
1.67
1.54
1.5
1.3
—
—
—
0
0
1129
10973
1.20
1.54
5.6
5.0
6.02
5.91
mmol/l
1.98
1064
10184
33
221
1.51
1.42
1.4
1.5
—
—
—
0
0
29
190
1.54
1.38
5.1
6.5
334.38
367.73
umol/l
0.67
24
173
58
436
1.35
1.35
1.7
1.7
14.48
10.81
u/ml
0.53
13
99
151
1280
1.20
1.32
5.1
4.4
313.97
246.87
u/l
0.72
143
1218
9
43
2.10
1.30
4.9
4.2
—
—
—
0
0
43
310
1.40
1.29
1.6
1.6
—
—
—
0
0
38
268
1.43
1.29
1.4
1.5
—
—
—
0
0
19
114
1.68
1.28
6.1
5.6
30.98
47.10
u/ml
—
8
39
137
1154
1.21
1.28
2.1
2.0
350.87
376.87
nmol/l
0.88
125
1073
12
62
1.94
1.28
1.1
1.0
1387.50
1612.90
miu/ml
0.35
12
62
364
3315
1.14
1.27
4.1
3.9
0.00
0.01
estimate
1.54
121
1154
137
1156
1.21
1.26
4.8
3.5
5.84
5.82
kpa
0.09
131
1123
44
321
1.38
1.24
1.1
1.1
9.28
6.25
eliau/ml
—
5
38
73
576
1.28
1.23
2.1
1.9
—
—
—
0
0
5
19
2.64
1.21
1.2
1.0
—
—
—
0
0
27
180
1.51
1.21
1.1
1.1
11.50
3.45
u/ml
1.14
14
79
288
2597
1.14
1.17
4.7
4.1
23.94
21.16
%
1.92
134
1139
43
319
1.36
1.12
1.7
1.6
—
—
—
0
0
28
192
1.47
1.12
1.6
1.2
2.75
4.03
u/ml
—
8
58
71
568
1.26
1.09
3.9
3.5
47.32
47.69
%
0.04
71
557
50
382
1.32
1.08
1.5
1.5
0.75
0.07
iu/ml
0.47
13
56
36
261
1.39
1.08
1.1
1.1
1.11
1.76
u/ml
0.35
22
148
28
194
1.45
1.07
1.1
1.1
4.32
1.87
u/ml
0.62
15
99
13
74
1.76
1.07
1.2
1.5
18.08
7.18
ug/l
0.35
13
64
5
22
2.28
1.03
12.4
2.5
55.00
112.18
u/l
—
5
22
11
60
1.84
1.03
1.5
1.2
109.00
461.11
u/l
1.24
11
54
22
147
1.50
1.01
1.3
2.1
—
1930.00
—
0
8
16
99
1.62
1.00
1.3
1.1
127.81
112.10
pmol/l
1.21
16
99
350
3226
1.12
0.99
5.5
4.9
2.27
2.15
ug/l
0.13
326
2950
41
311
1.33
0.96
1.4
1.2
—
—
—
0
0
35
260
1.36
0.94
2.3
2.3
120.08
87.53
ug/min
0.18
21
160
119
1376
0.85
0.92
5.2
4.7
32.51
31.85
%
0.25
80
923
40
305
1.32
0.91
1.3
1.3
—
—
—
0
0
106
905
1.19
0.91
2.3
2.4
9.46
8.04
ug/l
0.16
97
813
103
878
1.19
0.90
3.1
3.8
1.23
1.23
mmol/l
0.21
91
758
44
341
1.30
0.90
2.1
2.0
5.02
21.01
iu/l
0.47
15
139
55
440
1.26
0.88
1.8
1.5
—
—
—
0
0
27
194
1.40
0.88
1.7
1.2
3.70
4.60
u/ml
—
10
81
32
237
1.36
0.88
1.4
1.5
—
—
—
0
0
219
1979
1.13
0.88
3.3
3.0
0.73
0.73
ug/l
0.02
147
1163
8
43
1.87
0.87
4.0
2.7
0.57
0.61
mmol/l
—
8
43
21
145
1.46
0.85
1.9
1.7
—
—
—
0
0
210
1900
1.13
0.83
1.6
1.5
—
—
—
0
0
42
532
0.78
0.82
1.0
1.1
1.55
1.54
g/l
0.14
42
532
22
155
1.43
0.81
1.6
1.6
—
—
—
0
0
8
47
1.71
0.80
1.0
1.1
108.88
95.10
%
—
8
40
38
294
1.30
0.80
1.6
1.6
16466.15
12011.06
e6/l
0.16
33
201
59
483
1.23
0.80
1.7
1.7
3.95
5.27
mg/l
0.33
47
364
0
26
0.00
0.78
0.0
1.4
—
—
—
0
0
26
191
1.37
0.77
1.3
1.1
—
—
—
0
0
11
174
0.63
0.77
1.0
1.1
—
—
—
0
0
30
226
1.34
0.76
1.6
1.4
181.82
158.35
au/ml
0.86
11
67
81
688
1.19
0.76
1.7
1.7
—
—
—
0
0
5
24
2.09
0.74
1.2
1.3
—
—
—
0
0
68
570
1.20
0.74
1.2
1.4
—
—
—
0
0
9
54
1.67
0.74
1.0
1.1
110.76
212.55
iu/ml
—
9
54
7
38
1.85
0.73
1.7
1.3
—
—
—
0
0
10
60
1.67
0.72
1.4
1.8
1.41
4.44
nmol/l
—
10
54
13
84
1.55
0.72
1.0
1.0
—
—
—
0
0
7
40
1.75
0.71
1.0
1.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
42
336
1.26
0.71
2.4
3.0
0.36
0.36
iu/ml
0.05
26
183
16
109
1.47
0.71
2.3
1.3
1.75
0.74
u/ml
—
10
63
5
27
1.85
0.68
33.2
6.4
10.24
5.19
kpa
—
5
27
104
913
1.15
0.67
1.7
1.5
—
—
—
0
0
7
43
1.63
0.67
1.7
1.4
10.87
8.37
ug/l
—
7
43
56
467
1.21
0.66
2.3
2.0
1.49
1.97
ug/l
0.23
50
416
45
548
0.81
0.66
1.0
1.2
0.94
0.90
g/l
0.58
45
548
23
171
1.35
0.65
1.0
1.1
1.48
1.51
g/l
0.17
23
159
45
368
1.23
0.64
1.4
1.4
232.22
291.31
ug/g
0.93
29
216
28
216
1.30
0.63
1.1
1.1
2.35
1.42
u/ml
0.40
15
111
5
30
1.67
0.61
2.0
1.3
—
—
—
0
0
126
1130
1.13
0.61
3.0
3.2
—
—
—
0
0
22
165
1.34
0.60
1.0
1.0
1.19
0.31
u/ml
—
9
60
9
140
0.64
0.60
1.3
1.5
—
—
—
0
0
23
174
1.33
0.60
1.0
1.1
0.79
2.54
eliau/ml
—
10
81
47
390
1.21
0.60
2.3
2.9
—
—
—
0
0
12
80
1.50
0.60
1.5
1.4
126.69
165.14
pmol/l
0.54
12
80
8
52
1.54
0.59
1.4
1.9
—
—
—
0
0
8
52
1.54
0.59
1.4
1.9
—
—
—
0
0
0
22
0.00
0.59
0.0
2.2
—
8.17
—
0
12
0
22
0.00
0.59
0.0
1.9
—
0.60
—
0
15
27
210
1.29
0.59
1.6
1.7
—
—
—
0
0
41
496
0.82
0.58
1.0
1.1
0.78
0.67
ratio
—
5
55
6
35
1.72
0.57
1.2
1.2
—
—
—
0
0
22
167
1.32
0.57
1.1
1.4
0.55
11.21
nmol/l
0.50
22
161
32
395
0.81
0.55
1.5
1.6
1170.31
1001.52
mu/l
0.47
27
316
21
273
0.77
0.55
1.4
1.5
—
—
—
0
0
76
666
1.15
0.54
1.3
1.4
37.05
29.96
iu/l
0.91
68
569
139
1268
1.11
0.52
8.1
6.9
—
—
—
0
0
14
100
1.40
0.52
2.6
2.5
481.21
1169.97
mg
1.71
14
100
28
224
1.26
0.51
4.1
3.0
9.05
8.30
pmol/l
0.19
28
224
15
109
1.38
0.51
1.8
2.6
—
—
—
0
0
6
41
1.47
0.50
1.3
1.0
—
—
—
0
0
23
180
1.28
0.49
1.5
1.6
—
—
—
0
0
10
67
1.50
0.49
1.3
1.1
—
—
—
0
0
30
245
1.23
0.47
1.4
1.4
—
—
—
0
0
17
129
1.32
0.46
1.4
1.5
36.66
26.18
ng/l
0.26
17
129
46
395
1.17
0.44
1.5
1.3
—
—
—
0
0
29
238
1.22
0.44
1.3
1.5
—
—
—
0
0
5
32
1.56
0.42
1.2
1.1
—
—
—
0
0
5
32
1.56
0.42
1.2
1.2
—
—
—
0
0
24
194
1.24
0.42
1.3
1.5
—
—
—
0
0
6
95
0.63
0.42
2.7
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
0.11
—
0
10
94
854
1.11
0.41
1.3
1.2
184.27
138.35
u/ml
0.41
30
349
5
34
1.47
0.40
1.2
1.0
—
—
—
0
0
8
60
1.34
0.40
1.3
2.2
—
—
—
0
0
27
224
1.21
0.38
3.2
3.6
27.31
26.67
mg/l
0.02
17
153
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
9
68
1.33
0.37
1.1
1.2
—
—
—
0
0
13
98
1.33
0.37
1.1
1.1
298.38
284.07
mg/l
0.44
13
88
14
107
1.31
0.37
1.6
1.2
—
—
—
0
0
10
72
1.39
0.37
1.7
1.7
64.17
95.03
ng/l
—
10
72
122
1131
1.09
0.36
2.5
2.3
0.22
0.21
g/l
0.20
113
1066
9
71
1.27
0.36
1.7
1.5
7.22
7.66
u/l
—
9
59
6
42
1.43
0.35
1.0
1.1
—
—
—
0
0
11
145
0.76
0.34
1.4
1.5
—
—
—
0
0
10
73
1.37
0.34
1.2
1.2
—
—
—
0
0
31
265
1.17
0.33
1.4
1.2
—
47.56
—
0
5
14
109
1.29
0.33
1.6
1.6
—
—
—
0
0
27
228
1.19
0.33
1.1
1.1
6.16
3.98
u/ml
0.26
15
128
11
144
0.76
0.33
1.4
1.5
—
—
—
0
0
11
144
0.76
0.33
1.4
1.5
—
—
—
0
0
30
256
1.18
0.33
4.3
2.3
1.16
0.92
nmol/l
1.05
24
224
41
363
1.13
0.29
1.2
1.3
—
—
—
0
0
12
152
0.79
0.29
1.3
1.4
—
—
—
0
0
12
152
0.79
0.29
1.3
1.4
—
—
—
0
0
12
152
0.79
0.29
1.3
1.4
—
—
—
0
0
8
106
0.75
0.29
1.0
1.0
—
—
—
0
0
42
374
1.13
0.28
3.6
4.0
29.34
50.88
mg/l
1.21
36
322
136
1284
1.07
0.27
2.3
2.0
—
—
—
0
0
42
375
1.12
0.27
3.6
3.9
53.90
63.63
mg/l
0.22
36
323
67
616
1.09
0.26
1.2
1.1
—
—
—
0
0
38
425
0.89
0.26
1.9
1.9
—
—
—
0
0
10
127
0.79
0.25
1.9
2.4
29.60
28.17
mg/l
—
5
54
37
331
1.12
0.24
3.5
3.8
2.86
3.73
ratio
0.26
22
190
5
38
1.32
0.23
1.2
1.1
—
—
—
0
0
23
200
1.15
0.22
1.5
1.4
0.30
0.38
nmol/l
0.68
15
161
68
633
1.08
0.21
2.6
4.0
1.80
1.84
mmol/l
0.03
49
480
0
11
0.00
0.21
0.0
6.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
56.40
—
0
10
0
12
0.00
0.21
0.0
1.0
—
0.05
—
0
7
0
13
0.00
0.21
0.0
1.3
—
6.10
—
0
13
0
13
0.00
0.21
0.0
1.0
—
0.01
—
0
8
0
13
0.00
0.21
0.0
1.0
—
31.66
—
0
8
10
122
0.82
0.19
1.0
1.1
—
81.83
—
0
6
18
156
1.16
0.18
1.8
1.8
—
—
—
0
0
10
121
0.83
0.18
1.2
1.5
3.02
2.87
ug/l
—
5
104
7
62
1.13
0.17
1.1
1.2
7.14
9.03
mm/h
—
7
62
5
66
0.76
0.17
1.2
1.3
—
—
—
0
0
5
66
0.76
0.17
1.2
1.3
—
—
—
0
0
8
68
1.18
0.16
16.1
3.9
1.00
0.85
index
—
8
68
12
141
0.85
0.16
1.7
2.3
33.75
32.62
pg
0.56
12
141
48
447
1.08
0.16
4.0
3.4
43.00
3075.63
u/ml
0.78
42
391
25
225
1.11
0.16
1.4
1.4
—
—
—
0
0
25
225
1.11
0.16
1.4
1.4
—
—
—
0
0
26
287
0.90
0.16
1.3
1.4
75.05
226.13
pmol/l
2.08
26
281
121
1163
1.04
0.15
2.3
2.0
—
—
—
0
0
36
390
0.92
0.15
1.8
1.8
—
—
—
0
0
6
80
0.75
0.15
1.0
1.4
—
—
—
0
0
9
83
1.08
0.14
1.6
1.5
12.87
11.44
umol/l
—
9
78
13
113
1.15
0.13
1.2
1.1
—
—
—
0
0
27
249
1.09
0.12
1.4
1.3
250.65
225.58
u/ml
0.17
18
154
5
45
1.11
0.09
1.2
1.2
—
—
—
0
0
12
106
1.13
0.09
1.7
2.3
3.67
6.67
umol/l
—
7
79
113
1162
0.97
0.09
5.0
4.5
5.99
23.46
ug/l
1.48
93
948
5
48
1.04
0.09
1.6
2.6
12.48
190.03
ug/l
—
5
41
40
381
1.05
0.08
1.5
1.5
—
—
—
0
0
7
65
1.08
0.08
1.4
1.6
—
1631885.57
—
0
7
14
127
1.10
0.08
1.1
1.7
—
—
—
0
0
6
70
0.86
0.07
1.7
1.6
—
—
—
0
0
6
70
0.86
0.07
2.5
1.9
—
—
—
0
0
13
143
0.91
0.07
1.2
1.1
—
—
—
0
0
8
76
1.05
0.07
1.6
1.5
—
—
—
0
0
9
85
1.06
0.07
1.9
1.4
76.78
78.48
umol/l
—
9
85
11
122
0.90
0.07
1.5
1.2
—
—
—
0
0
36
345
1.04
0.06
1.3
1.3
—
—
—
0
0
13
119
1.09
0.06
1.0
1.1
—
—
—
0
0
54
554
0.97
0.04
1.7
1.6
0.23
0.36
mg/l
1.36
30
269
10
108
0.93
0.03
1.1
1.5
—
—
—
0
0
10
108
0.93
0.03
1.1
1.5
—
—
—
0
0
10
108
0.93
0.03
1.1
1.5
—
—
—
0
0
34
348
0.98
0.01
1.4
1.4
15.03
9.26
u/l
0.75
26
281
283
2839
1.00
0.01
2.9
2.4
—
—
—
0
0
25
252
0.99
0.00
4.6
1.7
—
—
—
0
0
156
1564
1.00
0.00
1.6
1.9
1.50
1.47
%
0.16
138
1382
27
271
1.00
0.00
2.1
1.5
5.27
32.95
e6/l
0.65
22
197
0
6
0.00
0.00
0.0
1.5
—
3.00
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
54
0.93
0.00
1.6
3.0
1.80
1.23
%
—
5
54
5
55
0.91
0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
7.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.0
—
—
—
0
0
7
74
0.95
-0.00
1.1
1.1
—
—
—
0
0
5
49
1.02
-0.00
1.2
1.2
—
75.67
—
0
6
9
90
1.00
-0.00
1.4
1.7
—
—
—
0
0
5
56
0.89
-0.00
1.2
1.7
—
—
—
0
0
6
66
0.91
-0.00
5.2
1.4
28.67
29.98
umol/l
—
6
57
11
110
1.00
-0.00
3.4
3.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
74
0.95
-0.00
1.4
1.9
—
—
—
0
0
5
56
0.89
-0.00
1.2
1.7
—
—
—
0
0
6
66
0.91
-0.00
1.7
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
5
56
0.89
-0.00
1.2
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
83
0.96
-0.00
1.6
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
5.3
—
—
—
0
0
8
83
0.96
-0.00
1.6
1.3
—
—
—
0
0
7
71
0.99
-0.00
1.3
1.2
—
—
—
0
0
5
56
0.89
-0.00
1.2
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_CORNEALNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALNAS | 1.154 [0.99, 1.34] | 0.064 |
| Birth year | 0.992 [0.98, 1.0] | 0.064 |
During the follow-up period (1.1.1998 — 31.12.2019), 407 out of 3842 females with H7_CORNEALNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALNAS | 1.221 [1.03, 1.44] | 0.019 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 340 out of 3257 males with H7_CORNEALNAS died.
Mortality risk
Mortality risk for people of age
years, who have H7_CORNEALNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.096% | 0.159% |
| 5 | 0.622% | 1.398% |
| 10 | 1.589% | 3.359% |
| 15 | 2.881% | 6.346% |
| 20 | 4.996% | 10.9% |
Relationships between endpoints
↥Index endpoint: H7_CORNEALNAS – Other and unspecified corneal deformities and disorders
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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