primary myelofibrosis: Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of approximately 1 case per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
1690 |
4. Check minimum number of eventsNone |
1690 |
5. Include endpointsNone |
1690 |
6. Filter based on genotype QC (FinnGen only) |
1470 |
Control definitions (FinnGen only)
- Control exclude
- C3_CANCER, C3_CANCER_WIDE
Extra metadata
- First used in FinnGen datafreeze
- DF8
Similar endpoints
↥List of similar endpoints to
Essential (haemorrhagic) thrombocythaemia
based on the number of shared cases.
Similar with more cases:
- Myeloproliferative diseases
- Liquid cancers
- Liquid cancers, including Hilmo
- Malignant neoplasm
- Malignant neoplasm
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7386 | 4434 | 2920 |
| Only index persons | 6776 | 4112 | 2664 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.13 | 0.08 |
| Only index persons | 0.13 | 0.15 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 65.45 | 66.09 | 64.42 |
| Only index persons | 64.72 | 65.35 | 63.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1470 | 875 | 595 |
| Unadjusted period prevalence (%) | 0.30 | 0.31 | 0.27 |
| Median age at first event (years) | 63.60 | 62.53 | 65.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1503
- Matched controls
- 15030
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
100.1
310.4
161
18
XW000
NOMESCO Finland
Bone marrow biopsy
63.3
307.7
576
146
9962/3-C42.1
ICD-O-3
Essential thrombocythemia of bone marrow
+∞
307.7
546
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
4058.4
307.7
1097
10
D47.3
ICD-10 Finland
Essential (haemorrhagic) thrombocythaemia
+∞
307.7
1429
*
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
114.7
307.7
233
24
D75.2
ICD-10 Finland
Essential thrombocytosis
977.8
307.7
689
13
L01XX05
ATC
hydroxycarbamide; oral
6528.1
307.7
1032
5
D45
ICD-10 Finland
Polycythaemia vera
738.6
258.8
248
*
L01XX35
ATC
anagrelide; oral
+∞
231.4
216
*
D47.1
ICD-10 Finland
Chronic myeloproliferative disease
+∞
176.6
166
*
L03AB05
ATC
interferon alfa-2b; parenteral
+∞
152.8
144
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
41.4
141.8
86
22
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.5
123.3
365
997
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
60.7
114.5
64
11
9961/3-C42.1
ICD-O-3
Primary myelofibrosis of bone marrow
+∞
93.7
89
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
87.3
83
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.3
85.6
248
655
L03AB04
ATC
interferon alfa-2a; parenteral
+∞
85.2
81
*
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
14.7
84.9
77
55
TPH00
NOMESCO Finland
Phlebotomy
182.3
83.1
86
5
9960/3-C42.1
ICD-O-3
Myeloproliferative neoplasm, NOS, of bone marrow
+∞
79.9
76
*
H02AB02
ATC
dexamethasone; systemic
10.9
78.6
86
83
9950/3-C42.1
ICD-O-3
Polycythemia vera of bone marrow
+∞
73.5
70
*
R79.8
ICD-10 Finland
Other specified abnormal findings of blood chemistry
15.8
66.8
58
38
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
66.1
63
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
341.6
66.0
66
*
212
Kela drug reimbursment
Gout
9.1
65.5
82
95
130
Kela drug reimbursment
Malignant tumour
+∞
63.0
60
*
WW500
NOMESCO Finland
Blood transfusion
7.9
61.6
86
114
SPAT1074
SPAT
Venesection
115.0
61.3
66
6
115
Kela drug reimbursment
Breast cancer
+∞
59.8
57
*
PJA12
NOMESCO Finland
Sentinel node biopsy
579.3
57.0
56
*
B03XA01
ATC
erythropoietin; parenteral
23.4
56.5
41
18
M04AA01
ATC
allopurinol; systemic
3.0
55.4
296
1144
174
Kela drug reimbursment
Ruxolitinib
+∞
54.5
52
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
5.2
53.7
115
235
B03XA02
ATC
darbepoetin alfa; parenteral
8.9
53.3
67
78
R79.9
ICD-10 Finland
Abnormal finding of blood chemistry, unspecified
13.4
49.6
47
36
374
Kela drug reimbursment
Ruxolitinib
+∞
48.2
46
*
B99
ICPC
Blood/lymph/spleen disease other
78.6
47.2
53
7
L01EJ01
ATC
ruxolitinib; oral
+∞
46.1
44
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
45.0
43
*
TPH00, ,
SPAT
123.9
45.0
48
*
A04AA02
ATC
granisetron; systemic, transdermal
70.7
42.3
48
7
D47.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
79.2
41.1
46
6
B01AB05
ATC
enoxaparin; parenteral
2.1
40.1
527
3028
HAB40
NOMESCO Finland
Wedge excision of mammary gland
13.4
40.1
38
29
Z51.5
ICD-10 Finland
Palliative care
3.9
36.3
113
309
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
35.6
34
*
116
Kela drug reimbursment
Prostate cancer
+∞
35.6
34
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
35.3
790
5425
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.0
33.8
157
554
L02BG04
ATC
letrozole; oral
10.2
33.7
38
38
L03AA04, ,
ATC
323.7
32.0
32
*
WZC00
NOMESCO Finland
Treatment plan or consultation
2.0
31.7
493
2964
A04AA01
ATC
ondansetron; systemic, rectal
4.2
31.3
85
210
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
40.0
31.3
39
10
B74
ICPC
Malignant neoplasm blood other
+∞
30.3
29
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
308.4
29.9
30
*
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
+∞
28.2
27
*
HAC20
NOMESCO Finland
Total mastectomy
102.0
27.7
30
*
WF002
NOMESCO Finland
Radical radiotherapy
30.7
27.3
36
12
L57.0
ICD-10 Finland
Actinic keratosis
2.5
26.5
175
740
L01BC06
ATC
capecitabine; oral
+∞
26.1
25
*
XX3DW
NOMESCO Finland
Time consuming IT work
3.3
26.1
103
329
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
40.9
25.9
32
8
B01AC14
ATC
[U] anagrelide
+∞
25.1
24
*
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
71.1
24.9
28
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
254.2
24.7
25
*
L03AA02
ATC
filgrastim; parenteral
91.7
24.7
27
*
A03FA01
ATC
metoclopramide; systemic, rectal
2.2
24.6
225
1098
JN4AD
NOMESCO Finland
Body CT examination
2.8
24.3
125
465
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
+∞
24.0
23
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
24.0
23
*
D75.8
ICD-10 Finland
Other specified diseases of blood and blood-forming organs
88.2
23.7
26
*
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
8.5
23.2
30
36
L01XE18
ATC
[U] ruxolitinib
+∞
23.0
22
*
C92.0
ICD-10 Finland
Acute myeloblastic leukaemia [AML]
+∞
23.0
22
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
23.0
22
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
121.9
22.6
24
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
121.9
22.6
24
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
5.3
22.3
45
87
JN4BD
NOMESCO Finland
Extensive body CT
3.1
21.9
93
310
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
+∞
21.9
21
*
C90.0
ICD-10 Finland
Multiple myeloma
+∞
21.9
21
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.0
21.2
96
333
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.8
20.9
110
414
C50.99
ICD-10 Finland
Breast, unspecified
212.8
20.6
21
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
212.8
20.6
21
*
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
5.5
20.5
40
75
B01AB10
ATC
tinzaparin; parenteral
2.4
20.1
154
695
XX7BT
NOMESCO Finland
Radioactive phosphorus therapy
+∞
19.8
19
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
18.8
18
*
9861/3-C42.1
ICD-O-3
Acute myeloid leukemia, NOS, of bone marrow
+∞
18.8
18
*
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
70.8
18.7
21
*
Y77
ICPC
Malignant neoplasm prostate
192.3
18.6
19
*
Z2221
NOMESCO Finland
Medical doctor
1.7
18.6
392
2523
Z3231
NOMESCO Finland
Registered nurse
1.8
18.5
386
2477
ZX120
NOMESCO Finland
Intravenous
2.5
18.1
117
488
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
+∞
17.7
17
*
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
+∞
17.7
17
*
L02BB03
ATC
bicalutamide; oral
+∞
17.7
17
*
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
+∞
17.7
17
*
L03AA13
ATC
pegfilgrastim; parenteral
96.2
17.6
19
*
ZZR00
NOMESCO Finland
Flap of skin
17.2
17.4
27
16
GDC01
NOMESCO Finland
Thoracoscopic lobectomy of lung
+∞
16.7
16
*
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
+∞
16.7
16
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
16.7
16
*
XW000, ,
SPAT
91.1
16.6
18
*
S97
ICPC
Chronic ulcer skin
2.3
16.6
128
579
D47.0
ICD-10 Finland
Histiocytic and mast cell tumours of uncertain and unknown behaviour
171.8
16.5
17
*
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
171.8
16.5
17
*
R04.0
ICD-10 Finland
Epistaxis
2.2
16.3
142
676
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
2.6
15.9
91
358
C44.11
ICD-10 Finland
Basocellular carcinoma of the skin of the eyelids including the corner of the eye
+∞
15.6
15
*
WB203
NOMESCO Finland
Simple adjuvant hormone therapy of malignancy
+∞
15.6
15
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.1
15.5
167
862
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
161.6
15.5
16
*
TNE20
NOMESCO Finland
Bone marrow aspiration, pelvis
38.5
15.4
19
5
L02BA01
ATC
tamoxifen; oral
38.5
15.4
19
5
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
15.4
452
3149
R50.9
ICD-10 Finland
Fever, unspecified
1.9
14.8
207
1170
L02BG03
ATC
anastrozole; oral
+∞
14.6
14
*
C34.12
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary adenocarcinoma
+∞
14.6
14
*
C50.90
ICD-10 Finland
Malignant tumor in other or unspecified location in mammary gland without histology
+∞
14.6
14
*
ZX112
NOMESCO Finland
Subcutaneous
6.4
14.6
24
38
WZC30
NOMESCO Finland
Teaching
1.9
14.4
198
1111
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
3.9
14.2
42
111
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
42.9
14.1
17
*
B28
ICPC
Limited function/disability (B)
12.8
13.9
24
19
NK6AN
NOMESCO Finland
Total body bone isotope imaging
30.3
13.9
18
6
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.3
13.9
104
464
B01AB04
ATC
dalteparin; parenteral
2.7
13.8
77
299
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
3.1
13.7
56
183
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.2
13.7
119
565
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
13.6
13
*
L01AB01
ATC
busulfan; systemic
+∞
13.6
13
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
13.5
318
2085
D05.1
ICD-10 Finland
Intraductal carcinoma in situ
141.2
13.5
14
*
THW99
NOMESCO Finland
Other minor procedure in surgery of mammary gland
26.0
13.4
18
7
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.6
13.1
76
301
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.4
13.1
46
137
R4110
NOMESCO Finland
Physiotherapy
1.6
12.9
385
2673
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
4.9
12.9
28
58
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
12.8
491
3611
HA1AA
NOMESCO Finland
X-ray mammography
2.8
12.7
65
241
2387B
ICD-9 Finland
Neoplasm of uncertain behaviour of other and unspecified sites and tissues, Other lymphatic and haematopoietic tissues[THROMBOCYTHAEMIA IDIOPATHICA]
+∞
12.5
12
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
12.5
12
*
8500/3-C50.4
ICD-O-3
Infiltrating duct carcinoma, NOS, of upper-outer quadrant of breast
+∞
12.5
12
*
C50.91
ICD-10 Finland
Malignant tumor in another specified localization in ductal mammary gland
+∞
12.5
12
*
C50.81
ICD-10 Finland
Overall malignant tumor of the mammary gland, ductal tumor
+∞
12.5
12
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
12.5
12
*
WF004
NOMESCO Finland
Palliative radiotherapy
131.1
12.5
13
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
131.1
12.5
13
*
Z03.1
ICD-10 Finland
Observation for suspected malignant neoplasm
5.7
12.4
23
41
A02BC02
ATC
pantoprazole; systemic
1.5
12.3
997
8515
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
37.9
12.2
15
*
C03CA01
ATC
furosemide; systemic
1.5
12.1
482
3565
L02AE02
ATC
leuprorelin; implant, parenteral
8.7
12.0
25
29
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
9.4
12.0
24
26
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
11.7
340
2339
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
30.3
11.6
15
5
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
11.6
298
1991
8520/3-C50.9
ICD-O-3
Lobular carcinoma, NOS, of breast, NOS
+∞
11.5
11
*
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
+∞
11.5
11
*
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
+∞
11.5
11
*
KEC00
NOMESCO Finland
Retropubic radical prostatectomy
+∞
11.5
11
*
2387X
ICD-9 Finland
Neoplasm of uncertain behaviour of other and unspecified sites and tissues, Other lymphatic and haematopoietic tissues[STATUS LYMPHO- ET MYELOPROLIFERATIVUS NUD]
+∞
11.5
11
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
120.9
11.4
12
*
N02AA05
ATC
oxycodone; systemic
1.7
11.3
228
1430
TPH07
NOMESCO Finland
Cathetrisation of artery
1.9
11.3
153
853
QAE99
NOMESCO Finland
Other excision or repair surgery of skin and subcutaneous tissue in head and neck
4.3
11.3
29
69
S77
ICPC
Malignant neoplasm of skin
35.3
11.3
14
*
J01DB01
ATC
cefalexin; oral
1.5
11.1
1166
10380
J01MA12
ATC
levofloxacin; systemic
1.7
11.0
249
1609
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.9
11.0
154
869
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
3.6
10.8
35
99
D46.7
ICD-10 Finland
Other myelodysplastic syndromes
28.2
10.7
14
5
C44.21
ICD-10 Finland
Basocellular carcinoma of the skin of the outer ear and the outer ear canal
60.4
10.6
12
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
1.9
10.6
146
818
D75
ICD-10 Finland
Other diseases of blood and blood-forming organs
110.8
10.4
11
*
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
+∞
10.4
10
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
10.4
10
*
DAB10
NOMESCO Finland
Partial excision of auricle
+∞
10.4
10
*
8120/3-C67.9
ICD-O-3
Transitional cell carcinoma, NOS, of bladder, NOS
+∞
10.4
10
*
8090/3-C44.4
ICD-O-3
Basal cell carcinoma, NOS, of skin of scalp and neck
+∞
10.4
10
*
C50.51
ICD-10 Finland
Malignant tumor of the lower outer quadrant of the mammary gland, ductal tumor
+∞
10.4
10
*
C50.42
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, lobular tumor
+∞
10.4
10
*
ZXC50
NOMESCO Finland
Cryotherapy
3.1
10.2
42
138
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
23.5
10.2
14
6
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.7
10.1
203
1270
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.8
10.0
168
1001
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
26.2
9.8
13
5
WZC15, ,
NOMESCO Finland
20.2
9.8
14
7
ZXE00
NOMESCO Finland
One hour or less
1.4
9.8
502
3868
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
3.4
9.8
34
101
X76
ICPC
Malignant neoplasm breast female
55.4
9.7
11
*
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
55.4
9.7
11
*
C50
ICD-10 Finland
Malignant neoplasm of breast
55.4
9.7
11
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.9
9.6
122
667
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
3.7
9.6
30
83
UJF32
NOMESCO Finland
Coloscopy
1.5
9.5
360
2613
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
3.0
9.5
40
134
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
9.4
9
*
KEC01
NOMESCO Finland
Percutaneous endoscopic radical prostatectomy
+∞
9.4
9
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
9.4
9
*
8140/3-C34.1
ICD-O-3
Adenocarcinoma, NOS, of upper lobe, lung
+∞
9.4
9
*
KE3AT
NOMESCO Finland
Transrectal gold marker implantation in prostate under ultrasound guidance
+∞
9.4
9
*
HA013
NOMESCO Finland
Radiotherapy after total ablation of mammary gland
+∞
9.4
9
*
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
9.4
9
*
C50.49
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, other or undeterminated histology
+∞
9.4
9
*
S18
ICPC
Laceration/cut
1.4
9.4
655
5325
C44.71
ICD-10 Finland
Basocellular carcinoma of the skin of the lower extremity including the hip
36.9
9.0
11
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.0
9.0
40
138
ZX090
NOMESCO Finland
Other technic of radiotherapy
18.7
8.9
13
7
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.8
8.9
126
712
B04
ICPC
Blood symptom/complaint
8.7
8.8
18
21
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
8.8
457
3517
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
3.7
8.7
27
74
S29
ICPC
Skin symptom/complaint other
1.5
8.6
288
2032
TQW99
NOMESCO Finland
Other minor procedure on skin
2.3
8.6
62
273
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
1.9
8.6
104
560
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.1
8.5
78
379
D06BB10
ATC
imiquimod; topical
2.2
8.5
71
333
D69.1
ICD-10 Finland
Qualitative platelet defects
27.7
8.5
11
*
HAB50
NOMESCO Finland
Partial excision of mammary gland with reconstructive operation
27.7
8.5
11
*
D73.5
ICD-10 Finland
Infarction of spleen
20.1
8.5
12
6
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
90.6
8.4
9
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
90.6
8.4
9
*
WVA20
NOMESCO Finland
Medicine administration
2.8
8.4
42
155
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
12.8
8.4
14
11
C92.1
ICD-10 Finland
Chronic myeloid leukaemia [CML], BCR/ABL-positive
+∞
8.3
8
*
C67.2
ICD-10 Finland
Malignant neoplasm: Lateral wall of bladder
+∞
8.3
8
*
C43.52
ICD-10 Finland
Malignant melanoma on the torso: 'superficial spreading' type
+∞
8.3
8
*
C50.11
ICD-10 Finland
Malignant tumor of the central part of the mammary gland,ductal tumor
+∞
8.3
8
*
C50.21
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor
+∞
8.3
8
*
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
+∞
8.3
8
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.0
8.3
83
417
KCD02
NOMESCO Finland
Transurethral resection of bladder
10.8
8.3
15
14
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.6
8.1
216
1450
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
2.8
8.0
38
136
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.6
8.0
182
1175
Z3226
NOMESCO Finland
Physiotherapist
1.5
8.0
237
1629
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
2.5
8.0
47
189
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
2.8
7.9
39
143
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
3.3
7.8
29
90
I81
ICD-10 Finland
Portal vein thrombosis
9.5
7.8
15
16
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.2
7.7
60
273
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.5
7.7
289
2083
UJF30
NOMESCO Finland
Ileoscopy through colon
1.7
7.7
144
883
HAE10
NOMESCO Finland
Reconstruction of breast using graft or flap
45.2
7.7
9
*
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
5.9
7.7
20
34
308
Kela drug reimbursment
Alprostadil, sildenafil and combination product containing aviptadil and phentolamine
25.1
7.6
10
*
D75.0
ICD-10 Finland
Familial erythrocytosis
25.1
7.6
10
*
JN4CD
NOMESCO Finland
Very extensive body CT
3.5
7.6
25
72
N02BE01
ATC
paracetamol; systemic, rectal
1.5
7.5
1297
12081
AA1BD
NOMESCO Finland
Extensive CT of head and brain
3.1
7.5
30
98
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
3.6
7.4
24
68
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.5
7.4
270
1934
YL1AD
NOMESCO Finland
CT examination of pelvis for dose design of radiotherapy
80.5
7.4
8
*
C67.9
ICD-10 Finland
Malignant neoplasm: Bladder, unspecified
80.5
7.4
8
*
DKW00
NOMESCO Finland
Cauterisation of mucosa of nose
4.0
7.4
20
50
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
7.3
678
5696
A79
ICPC
Malignancy NOS
+∞
7.3
7
*
B73
ICPC
Leukaemia
+∞
7.3
7
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
7.3
7
*
8097/3-C44.9
ICD-O-3
Basal cell carcinoma, nodular of skin, NOS
+∞
7.3
7
*
C54.11
ICD-10 Finland
Adenocarcinoma of the endometrium
+∞
7.3
7
*
C44.81
ICD-10 Finland
Overall basocellular carcinoma of the skin
+∞
7.3
7
*
R51.80
ICD-10 Finland
Headache
1.5
7.3
208
1416
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.8
7.3
111
643
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
10.1
7.0
13
13
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
2.0
7.0
78
409
AA1AD
NOMESCO Finland
CT of head and brain
1.4
7.0
436
3440
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
13.8
6.9
11
8
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.4
6.9
359
2746
ZYC01
NOMESCO Finland
Remote contact by phone
1.9
6.8
80
426
JN3AD
NOMESCO Finland
Abdominal CT examination
1.6
6.8
159
1033
WX402
NOMESCO Finland
General anaesthesia
1.5
6.8
238
1692
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
22.6
6.7
9
*
Z31.5
ICD-10 Finland
Genetic counselling
2.3
6.7
48
212
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.4
6.7
350
2679
R86.0
ICD-10 Finland
Abnormal findings in specimens from male genital organs, abnormal level of enzymes
3.7
6.6
20
54
R4190
NOMESCO Finland
Nutritional therapy
2.6
6.6
37
145
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.5
6.6
226
1596
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.6
6.6
148
951
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
7.8
6.6
14
18
N02AX02
ATC
tramadol; systemic, rectal
1.3
6.5
573
4755
L02BG06
ATC
exemestane; oral
70.1
6.4
7
*
A04AD12
ATC
aprepitant; systemic
70.1
6.4
7
*
J01MA02
ATC
ciprofloxacin; systemic
1.3
6.4
514
4207
306
Kela drug reimbursment
Erythropoietin and darbepoetin
18.1
6.3
9
5
L01AX03
ATC
temozolomide; systemic
+∞
6.3
6
*
9989/3-C42.1
ICD-O-3
Myelodysplastic syndrome, NOS, of bone marrow
+∞
6.3
6
*
C34.1
ICD-10 Finland
Malignant neoplasm: Upper lobe, bronchus or lung
+∞
6.3
6
*
WF001
NOMESCO Finland
Preoperative radiotherapy
+∞
6.3
6
*
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
+∞
6.3
6
*
CBB50
NOMESCO Finland
Excision of lesion of eyelid and reconstruction using graft or flap
+∞
6.3
6
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
6.3
6
*
8090/3-C44.2
ICD-O-3
Basal cell carcinoma, NOS, of external ear
+∞
6.3
6
*
WB123
NOMESCO Finland
Demanding adjuvant cytostatic therapy
+∞
6.3
6
*
8380/3-C54.1
ICD-O-3
Endometrioid adenocarcinoma, NOS, of endometrium
+∞
6.3
6
*
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
6.3
6
*
128
Kela drug reimbursment
Cancers of female genital organs
+∞
6.3
6
*
D47.7
ICD-10 Finland
Other specified neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
26.8
6.2
8
*
ZXE20
NOMESCO Finland
More than three and less than five hours
1.6
6.2
152
999
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.4
6.2
259
1902
ZXC20
NOMESCO Finland
Use of chemical agents
3.2
6.2
24
77
B01AA03
ATC
warfarin; systemic
1.4
6.2
280
2088
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
6.1
573
4787
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.4
6.1
39
164
JFF23
NOMESCO Finland
Transversostomy
8.6
6.1
12
14
DHB00
NOMESCO Finland
Excision of lesion of external nose
8.6
6.1
12
14
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
697
1165
10.29
307.65
3.7
2.0
73.57
68.91
e9/l
2.41
485
861
1148
1237
36.06
307.65
10.9
2.2
278.37
233.22
u/l
16.73
1121
1148
566
131
68.70
307.65
1.0
1.0
—
—
—
0
0
804
1515
10.26
307.65
3.7
2.1
1.82
1.79
%
0.29
733
1337
490
108
66.83
307.65
1.3
1.2
—
—
—
0
0
439
208
29.40
307.65
1.4
1.2
27.04
16.82
u/l
0.90
398
178
1280
6015
8.60
246.47
19.5
5.8
25.81
27.42
%
6.77
1260
5667
1323
6465
9.74
242.47
18.3
5.7
0.61
0.59
e9/l
1.51
1228
5492
1265
5931
8.15
242.45
18.8
5.8
59.78
57.65
%
9.86
1247
5631
1323
6485
9.68
240.98
18.3
5.7
0.07
0.04
e9/l
33.61
1229
5508
1331
6604
9.87
237.87
18.6
5.7
1.88
1.86
e9/l
0.20
1251
5744
942
3485
5.56
237.14
4.5
2.4
335.44
348.17
umol/l
3.50
882
3002
1332
6698
9.69
231.80
19.7
5.8
0.21
0.20
e9/l
0.60
1244
5785
660
1865
5.53
228.65
3.0
2.7
23.98
22.52
%
1.90
634
1721
1344
6948
9.83
222.65
24.4
6.4
4.64
4.26
e9/l
2.87
1254
5923
683
2051
5.27
218.44
2.9
2.6
2.33
2.31
g/l
0.53
652
1882
701
2214
5.06
209.14
3.0
2.6
14.09
12.92
umol/l
4.06
672
2043
1209
6354
5.62
175.33
10.1
3.9
11.71
11.85
umol/l
0.11
1176
5975
226
313
8.32
158.50
2.6
2.1
3.29
3.52
g/l
1.49
216
292
260
603
5.00
106.73
1.9
1.6
1.13
1.51
g/l
8.20
227
522
1034
5996
3.32
102.58
4.4
3.0
127.33
118.74
ug/l
0.53
971
5547
731
3553
3.06
97.71
2.8
2.3
3.40
2.80
mg/l
4.03
635
3034
982
5642
3.14
96.64
25.2
10.1
0.05
0.00
e9/l
3.21
850
4560
116
135
9.23
92.72
10.7
2.3
1.65
1.27
%
0.47
101
106
1369
9820
5.42
91.07
17.6
5.8
80.09
76.91
u/l
1.92
1340
9147
175
334
5.80
88.97
2.2
1.9
95.86
90.28
%
2.38
150
327
1059
6734
2.94
79.53
8.2
6.0
1.22
1.22
mmol/l
0.15
912
5788
952
5992
2.61
68.24
7.6
5.6
1.22
1.21
mmol/l
4.62
891
5436
597
3089
2.55
64.02
5.2
3.6
85.63
88.31
%
1.75
568
3011
131
266
5.30
61.76
1.7
1.5
—
—
—
0
0
139
322
4.65
56.00
2.5
2.1
173.65
186.93
%
0.86
132
303
143
339
4.56
55.98
3.4
2.7
1.30
1.67
mg/l
5.99
138
296
76
99
8.03
55.18
10.6
2.4
63.96
57.52
%
1.87
60
75
718
4282
2.30
53.38
2.1
1.7
20.49
20.57
nmol/l
0.05
646
3541
882
5750
2.29
52.63
5.8
3.9
36.06
35.74
g/l
1.01
840
5329
314
1359
2.66
46.78
4.0
2.1
7.36
7.20
umol/l
0.04
291
1190
937
6532
2.15
43.79
2.7
2.2
93.45
95.66
pmol/l
0.77
568
3252
268
1108
2.73
43.49
2.5
1.6
66.47
67.02
g/l
0.52
244
1005
388
2006
2.26
38.25
3.0
2.5
0.82
0.82
mmol/l
0.03
374
1861
1042
7800
2.10
37.30
5.8
4.6
6.54
6.77
mmol/l
3.82
1011
7394
386
2023
2.22
36.60
2.6
1.9
31.09
29.65
s
5.01
366
1959
137
443
3.30
34.14
2.9
1.5
33.93
33.34
mg/l
0.06
127
373
137
445
3.29
33.89
2.9
1.5
59.88
41.00
mg/l
0.37
127
377
480
2837
2.02
32.56
2.0
1.7
1.04
1.25
mg/l
0.81
382
2205
149
536
2.98
30.92
2.5
1.4
2.87
2.91
g/l
0.23
132
473
1208
9870
2.14
30.03
5.5
4.5
12.58
12.26
mm/h
0.29
1139
9216
30
25
12.22
29.93
6.8
1.9
1.13
0.98
%
0.18
30
25
123
407
3.20
29.45
2.7
1.4
0.04
0.00
g/l
0.47
106
373
153
576
2.84
29.19
2.5
1.4
3.47
3.69
g/l
1.35
137
513
153
576
2.84
29.19
2.5
1.4
6.77
7.50
g/l
6.24
137
512
153
576
2.84
29.19
2.5
1.4
4.10
4.27
g/l
2.25
137
513
137
489
2.98
28.79
2.7
1.4
1.42
0.39
g/l
2.29
118
419
119
393
3.20
28.57
2.5
1.4
0.00
0.00
g/l
-0.00
101
352
324
1731
2.11
28.43
4.1
5.1
1.07
1.03
mmol/l
2.34
306
1579
114
374
3.22
27.66
2.5
1.4
0.00
0.00
g/l
-0.00
101
351
199
881
2.45
27.34
2.4
2.3
10.10
10.89
g/l
1.99
182
810
116
389
3.15
27.13
2.9
1.5
7.05
1.38
ratio
0.47
67
229
836
6190
1.79
26.31
19.1
17.2
1.32
1.31
inr
0.18
694
5161
416
2531
1.89
24.75
1.8
1.8
1041.35
1162.01
nmol/l
2.06
305
1902
131
502
2.76
24.09
2.4
1.4
10.78
10.40
g/l
0.47
113
436
159
678
2.50
23.57
2.9
1.5
3.97
2.70
ug/l
0.90
115
511
36
53
6.93
23.41
2.1
1.5
—
—
—
0
0
36
53
6.93
23.41
2.1
1.5
—
—
—
0
0
161
702
2.45
22.72
2.0
1.4
1.27
1.23
g/l
0.11
147
647
67
186
3.72
21.04
4.2
5.6
1137.13
392.77
iu/ml
—
8
26
1397
12576
2.57
20.43
29.6
14.7
20.97
23.92
mg/l
3.16
1209
10177
588
4147
1.69
20.25
4.2
2.6
32.83
34.21
u/l
0.21
562
3889
219
1150
2.06
19.58
4.5
6.8
9.80
10.35
mmol/l
0.54
208
1096
737
5574
1.63
18.90
4.9
2.4
—
—
estimate
—
0
0
93
349
2.77
17.77
3.6
3.8
1.30
1.74
index
0.40
47
176
606
4423
1.62
17.56
3.0
2.2
2.34
2.36
mmol/l
2.41
548
3877
357
2271
1.75
17.48
2.2
1.9
—
—
—
0
0
431
2895
1.69
17.28
4.5
2.0
—
—
—
0
0
60
180
3.43
16.81
1.2
1.2
1.86
2.74
u/ml
0.30
28
58
513
3636
1.62
16.51
3.8
3.1
0.38
0.41
e6/l
0.11
379
2661
172
884
2.07
16.18
1.7
1.6
—
—
—
0
0
644
4864
1.57
15.60
4.4
3.8
146.13
126.10
e6/l
0.20
454
3372
26
43
6.14
15.15
1.4
2.4
—
—
—
0
0
571
4255
1.55
14.35
3.9
3.2
59.63
82.98
e6/l
0.28
436
3233
396
2714
1.62
14.23
3.1
2.2
2.43
2.45
mmol/l
2.13
362
2395
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
87
359
2.51
13.78
2.9
2.8
0.32
0.37
iu/ml
0.78
49
209
180
994
1.92
13.75
3.5
3.1
1.22
1.23
mmol/l
0.46
151
829
863
7094
1.51
13.31
4.1
4.0
0.00
0.02
estimate
1.96
208
1325
602
4593
1.52
13.30
3.3
3.2
2511.55
1367.33
ng/l
2.43
532
3954
184
1041
1.87
13.03
2.0
2.1
0.21
0.20
g/l
0.60
169
957
848
6965
1.50
12.98
4.0
4.0
0.00
0.00
estimate
-0.00
212
1379
53
174
3.12
12.89
1.2
1.2
4.48
7.51
u/ml
0.39
25
75
1415
13179
2.26
12.80
33.1
18.3
4.00
3.98
mmol/l
2.22
1393
12873
1413
13158
2.23
12.70
30.9
18.2
139.56
139.79
mmol/l
2.70
1391
12876
855
7066
1.49
12.47
4.0
4.0
5.69
2.22
estimate
0.25
216
1425
270
1736
1.68
12.28
2.0
1.8
—
—
—
0
0
359
2489
1.58
12.01
1.5
1.3
2.38
2.57
g/l
0.80
221
1435
68
267
2.62
11.94
2.0
2.0
656.95
32.14
u/ml
0.49
61
213
70
282
2.55
11.68
1.7
1.4
—
—
—
0
0
152
845
1.89
11.34
1.7
1.7
—
—
—
0
0
410
2964
1.53
11.28
2.9
2.6
4.73
5.97
e6/l
1.49
378
2686
304
2057
1.60
11.20
3.5
2.9
1.85
2.85
e6/l
1.17
137
982
1334
12271
1.77
11.14
30.7
14.2
76.99
77.08
ml/min/173m2
0.06
1264
11311
51
180
2.90
10.98
1.0
1.1
—
—
—
0
0
249
1616
1.65
10.84
2.0
1.8
—
—
—
0
0
50
178
2.87
10.61
1.6
1.4
—
—
—
0
0
384
2790
1.51
10.16
4.2
4.2
848.41
466.65
ng/l
0.26
313
2271
983
8544
1.44
9.73
5.1
4.9
5890.82
2279.60
e6/l
0.30
11
129
64
271
2.42
9.65
1.6
1.4
—
—
—
0
0
189
1175
1.70
9.65
2.2
2.1
32.46
35.83
u/l
0.68
162
958
1316
12161
1.66
9.51
5.7
4.6
1.26
1.29
mmol/l
0.57
1256
11070
135
767
1.84
9.40
3.1
3.1
4.33
4.53
pmol/l
1.87
110
670
19
37
5.19
9.37
1.4
1.1
67.63
83.18
%
—
8
17
321
2289
1.51
9.18
3.4
2.8
0.97
1.37
e6/l
0.86
154
1223
70
321
2.24
8.83
1.8
2.1
16.63
12.10
mg/l
0.76
62
296
1414
13385
1.95
8.75
26.9
10.7
24.74
25.09
u/l
0.38
1395
12890
13
8
16.38
8.55
1.5
1.1
—
—
—
0
0
933
8132
1.39
8.42
3.7
3.2
55.19
46.43
u/l
2.45
893
7544
18
37
4.91
8.37
1.4
1.2
66.88
88.28
%
—
8
18
14
12
11.76
8.08
1.6
1.8
—
—
—
0
0
167
1065
1.64
7.70
3.3
2.4
60.11
64.64
ml/min/173m2
1.01
98
436
45
181
2.53
7.62
1.2
1.3
169.13
166.59
au/ml
0.05
16
58
1298
12093
1.54
7.48
6.2
5.5
2.03
1.97
mu/l
0.96
1230
11104
47
198
2.42
7.24
1.2
1.2
266.21
255.31
u/ml
0.10
34
109
1419
13540
1.86
7.18
40.2
19.4
79.94
78.34
umol/l
1.17
1406
13349
22
61
3.65
7.04
1.1
1.3
12.05
9.57
u/l
0.39
22
53
16
23
7.02
7.00
1.4
1.2
73.63
88.20
%
—
8
5
52
233
2.28
6.98
1.8
1.5
—
—
—
0
0
185
1239
1.56
6.95
1.9
1.8
429.24
368.09
nmol/l
3.10
171
1120
557
4592
1.34
6.62
2.1
2.2
132.81
222.13
u/l
3.91
523
4326
89
499
1.83
6.51
1.8
1.7
1.59
1.71
ug/l
0.06
80
437
45
197
2.32
6.40
1.5
1.3
—
—
—
0
0
201
1401
1.50
6.28
3.1
3.1
1.39
1.90
mmol/l
0.93
179
1227
215
1521
1.48
6.25
7.7
7.1
13.03
11.51
kpa
2.13
209
1461
1117
10239
1.35
6.04
4.8
4.4
15.13
14.90
pmol/l
2.22
1027
9324
11
11
10.06
6.03
1.5
1.1
—
—
—
0
0
30
113
2.69
5.84
1.3
1.5
136658.35
92912.97
e6/l
0.16
20
59
444
3599
1.33
5.76
3.9
3.4
0.02
0.24
estimate
0.47
189
1070
28
103
2.75
5.71
1.7
1.3
—
—
—
0
0
210
1506
1.46
5.68
7.5
7.0
0.65
1.09
mmol/l
0.72
171
1241
33
133
2.51
5.64
1.3
1.5
—
—
—
0
0
20
61
3.31
5.59
1.2
1.1
—
—
—
0
0
47
223
2.14
5.56
1.4
1.3
—
—
—
0
0
38
165
2.34
5.54
1.3
1.3
—
—
—
0
0
200
1429
1.46
5.51
3.1
3.1
5.78
5.83
kpa
0.31
193
1388
61
320
1.94
5.51
3.1
2.9
7.76
7.94
kpa
0.43
61
313
32
129
2.51
5.47
1.3
1.4
1395.04
1548.19
e6/l
0.14
23
89
52
259
2.04
5.43
1.6
1.4
—
—
—
0
0
1337
12695
1.48
5.36
6.7
5.4
1.36
1.48
mmol/l
20.38
1283
11684
495
4118
1.30
5.23
2.8
2.4
55.04
60.34
u/l
1.95
451
3777
29
114
2.57
5.23
1.8
1.3
—
—
—
0
0
5
0
+∞
5.21
1.0
0.0
—
—
—
0
0
70
395
1.81
5.08
1.3
1.7
0.23
0.23
g/l
0.07
65
380
1342
12778
1.47
5.03
6.8
5.5
4.19
4.58
mmol/l
39.85
1290
11847
33
141
2.37
5.01
2.4
2.0
16.30
37.21
u/ml
1.13
27
129
1361
12997
1.50
5.01
7.7
6.3
2.37
2.64
mmol/l
29.47
1312
12016
70
397
1.80
5.00
1.2
1.2
—
—
—
0
0
72
412
1.79
4.99
2.3
2.9
—
—
—
0
0
121
795
1.57
4.97
3.1
3.2
23.89
24.26
mmol/l
0.59
121
783
46
227
2.06
4.95
1.6
1.3
—
—
—
0
0
133
894
1.54
4.94
3.4
3.5
5.13
5.19
kpa
0.34
126
855
39
181
2.19
4.90
1.6
1.3
—
—
—
0
0
180
1291
1.45
4.86
4.0
3.2
—
—
—
0
0
1308
12413
1.41
4.83
7.2
7.0
37.74
39.88
mmol/mol
18.28
1253
11568
1328
12640
1.43
4.79
6.0
5.5
5.90
6.01
mmol/l
2.83
1235
11527
28
115
2.46
4.64
1.2
1.1
—
—
—
0
0
1420
13729
1.62
4.45
51.9
22.3
446.44
248.11
e9/l
256.35
1401
13398
1420
13732
1.62
4.40
51.6
22.3
97.07
91.38
fl
73.85
1408
13541
18
60
3.02
4.40
2.7
4.6
—
—
—
0
0
26
106
2.48
4.39
3.1
2.2
—
—
—
0
0
1420
13734
1.61
4.38
51.7
22.3
4.18
4.48
e12/l
46.66
1398
13338
1420
13734
1.61
4.38
52.3
22.7
39.47
40.30
%
8.02
1408
13540
57
317
1.83
4.37
1.9
1.7
—
—
—
0
0
1420
13735
1.61
4.36
51.7
22.4
8.12
6.72
e9/l
15.63
1398
13340
15
45
3.36
4.33
1.5
1.1
—
—
—
0
0
15
45
3.36
4.33
1.5
1.1
—
—
—
0
0
15
45
3.36
4.33
1.5
1.1
—
—
—
0
0
15
45
3.36
4.33
1.5
1.1
—
—
—
0
0
1420
13738
1.61
4.32
52.1
22.5
130.14
135.20
g/l
27.95
1410
13552
15
38
3.98
4.30
1.1
1.3
—
—
—
0
0
14
35
4.03
4.10
1.0
1.4
—
—
—
0
0
18
63
2.88
4.07
4.6
4.6
0.78
1.02
index
0.87
18
63
80
501
1.63
4.05
2.3
1.7
—
—
—
0
0
111
752
1.51
4.01
2.9
3.3
2.23
1.94
mmol/l
0.37
80
545
121
835
1.49
4.00
10.3
8.5
93.77
93.17
%
0.36
121
830
84
535
1.60
3.98
1.7
2.0
37.05
39.31
u/l
0.46
73
468
16
54
2.98
3.85
1.4
2.6
1130.13
992.89
u/ml
0.10
16
54
107
730
1.50
3.76
3.2
3.4
1.02
1.02
ratio
0.01
98
673
74
466
1.62
3.69
2.0
1.7
—
—
—
0
0
355
2960
1.26
3.48
1.3
1.3
1.85
1.42
u/ml
0.33
56
793
597
5271
1.22
3.44
4.2
4.0
0.02
0.13
estimate
0.64
190
1111
55
329
1.70
3.36
1.1
1.3
—
—
—
0
0
46
262
1.78
3.33
1.5
1.3
—
—
—
0
0
46
262
1.78
3.33
1.5
1.3
—
—
—
0
0
20
83
2.43
3.31
1.4
1.4
—
—
—
0
0
28
135
2.09
3.29
1.4
1.4
—
—
—
0
0
6
7
8.60
3.26
1.7
1.3
—
—
—
0
0
16
60
2.68
3.23
1.8
1.2
42.62
39.27
g/l
1.62
16
60
65
411
1.61
3.23
1.2
1.3
3.50
7.52
u/ml
—
6
66
607
5396
1.21
3.20
4.5
4.0
37.33
80.30
ng/l
1.59
478
3928
6
8
7.52
3.05
1.0
1.0
—
—
—
0
0
26
126
2.08
3.03
1.2
1.2
—
—
—
0
0
57
357
1.62
2.96
1.1
1.1
—
—
—
0
0
451
3924
1.21
2.92
4.3
4.1
0.00
0.00
estimate
0.69
195
1295
51
807
0.62
2.91
1.5
1.8
3.19
3.48
mmol/l
1.30
33
591
24
115
2.10
2.89
1.2
1.2
—
—
—
0
0
57
360
1.61
2.87
1.1
1.1
—
—
—
0
0
693
6283
1.19
2.85
2.6
2.5
79.66
79.18
nmol/l
0.17
610
5572
32
173
1.87
2.78
1.3
1.3
0.18
0.20
nmol/l
0.38
23
146
147
1126
1.34
2.75
3.3
3.6
89.67
90.12
ng/l
0.02
132
965
301
2531
1.24
2.70
1.3
1.3
33.50
36.64
iu/ml
0.15
80
776
10
29
3.46
2.69
1.6
1.1
—
—
—
0
0
10
29
3.46
2.69
1.6
1.1
—
—
—
0
0
10
29
3.46
2.69
1.6
1.1
—
—
—
0
0
24
119
2.03
2.67
1.2
1.2
—
—
—
0
0
24
119
2.03
2.67
1.2
1.2
—
—
—
0
0
156
1214
1.32
2.62
3.4
3.2
163.49
209.58
ng/l
1.70
149
1116
61
401
1.54
2.62
1.6
1.7
—
—
—
0
0
769
7073
1.18
2.59
3.0
2.7
—
—
—
0
0
122
918
1.36
2.57
2.5
2.5
21.45
21.58
au/ml
0.00
15
88
32
178
1.82
2.57
1.1
1.4
255.70
316.45
pmol/l
0.74
23
157
11
36
3.07
2.56
26.8
33.0
118.45
138.79
ug/l
0.66
11
28
19
88
2.17
2.51
1.6
1.2
—
—
—
0
0
19
88
2.17
2.51
1.6
1.2
—
—
—
0
0
19
88
2.17
2.51
1.6
1.2
—
—
—
0
0
27
144
1.89
2.47
1.2
1.2
—
—
—
0
0
22
109
2.03
2.46
1.2
1.2
—
—
—
0
0
12
45
2.68
2.45
1.2
1.6
—
1687199.83
—
0
6
10
32
3.14
2.43
1.0
1.2
—
—
—
0
0
111
832
1.36
2.41
1.3
1.3
52.78
50.68
au/ml
—
9
59
52
337
1.56
2.40
1.2
1.2
1.38
6.20
u/ml
—
6
21
24
125
1.93
2.36
4.8
3.8
13.33
11.79
index
0.68
18
63
16
71
2.27
2.34
1.3
2.2
—
—
—
0
0
16
72
2.24
2.28
1.4
1.3
—
—
—
0
0
14
60
2.35
2.22
1.4
1.4
—
—
—
0
0
28
158
1.79
2.18
6.6
4.2
—
—
—
0
0
26
144
1.82
2.15
1.3
1.4
273.38
274.95
mosm/kgh2o
0.12
21
103
632
5790
1.16
2.09
2.1
1.9
1.32
1.33
mmol/l
0.04
547
4831
17
82
2.09
2.07
1.5
1.6
—
—
—
0
0
29
170
1.72
2.01
1.5
1.3
—
—
—
0
0
89
668
1.35
1.96
1.6
1.5
—
—
—
0
0
14
64
2.20
1.94
1.5
1.3
—
—
—
0
0
8
27
2.97
1.93
1.3
1.1
—
—
—
0
0
6
16
3.76
1.93
1.7
1.5
—
—
—
0
0
6
16
3.76
1.93
1.3
2.1
6.67
4.75
ug/l
—
6
16
81
601
1.37
1.93
1.4
1.8
8.89
7.90
iu/ml
0.12
14
137
48
323
1.50
1.93
1.1
1.1
0.89
7.94
eliau/ml
—
7
31
6
17
3.54
1.84
1.5
1.2
—
—
—
0
0
33
206
1.62
1.84
1.1
1.1
—
16.11
—
0
9
12
54
2.23
1.74
1.3
1.3
—
—
—
0
0
187
1570
1.22
1.73
2.2
2.3
181.81
140.13
ug/g
0.43
145
1245
14
68
2.07
1.70
1.2
1.1
—
—
—
0
0
8
31
2.59
1.66
2.3
1.6
—
—
—
0
0
85
1091
0.77
1.62
1.8
2.1
3.95
3.46
ratio
2.23
67
878
8
32
2.51
1.59
1.1
1.0
—
—
—
0
0
115
924
1.26
1.59
2.1
2.8
126.96
130.90
g/l
1.11
109
893
19
106
1.80
1.59
1.3
1.5
26.82
22.03
ng/l
0.40
19
106
54
391
1.40
1.53
1.3
1.2
30.61
29.12
iu/l
0.14
48
337
24
147
1.64
1.48
1.0
1.1
—
—
—
0
0
11
52
2.12
1.44
1.4
1.3
—
—
—
0
0
50
364
1.39
1.40
1.3
1.3
—
—
—
0
0
70
541
1.31
1.34
1.3
1.3
—
—
—
0
0
21
332
0.63
1.32
1.4
1.2
1.44
1.55
g/l
1.45
21
332
21
129
1.64
1.30
1.1
1.1
—
—
—
0
0
84
670
1.27
1.28
2.6
2.9
25.15
25.46
mmol/l
0.28
78
642
24
155
1.56
1.23
1.7
5.6
8.28
7.57
mmol/l
0.39
19
131
11
56
1.97
1.22
1.1
1.3
107.85
171.65
mmol/24h
2.58
11
56
22
140
1.58
1.20
1.2
1.2
—
—
—
0
0
22
140
1.58
1.20
1.3
1.2
—
—
—
0
0
60
463
1.31
1.19
2.7
3.7
24.49
24.78
mmol/l
0.31
53
421
23
150
1.54
1.14
1.2
1.2
—
—
—
0
0
23
150
1.54
1.14
1.2
1.2
—
—
—
0
0
22
142
1.56
1.14
1.3
1.2
—
—
—
0
0
8
40
2.01
1.12
1.3
1.3
—
—
—
0
0
8
40
2.01
1.12
1.3
1.3
—
—
—
0
0
429
3971
1.11
1.09
4.9
4.3
3.67
1.96
ug/l
0.64
374
3587
268
2414
1.13
1.08
1.2
1.3
12.26
13.46
u/ml
0.10
81
912
484
5172
0.91
1.04
3.3
3.4
7.07
7.24
mmol/l
0.36
402
4355
5
22
2.28
1.03
1.0
1.1
—
—
—
0
0
5
22
2.28
1.03
1.8
1.0
—
—
—
0
0
11
60
1.84
1.03
1.2
1.3
—
—
—
0
0
11
60
1.84
1.03
1.2
1.3
—
—
—
0
0
480
5107
0.91
0.93
3.9
4.2
9.94
7.79
mg/mmol
0.46
284
3122
22
150
1.47
0.93
1.2
1.2
—
—
—
0
0
1074
10447
1.10
0.91
45.1
19.3
329.06
331.92
g/l
13.28
1067
10389
48
378
1.28
0.87
1.5
1.4
260.96
301.38
ug/g
0.77
31
226
27
368
0.73
0.87
1.6
1.5
5252.37
12828.01
e6/l
2.23
19
261
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
10
57
1.76
0.83
1.2
1.2
—
—
—
0
0
6
32
1.88
0.82
1.0
1.2
—
—
—
0
0
198
1792
1.12
0.78
1.6
1.5
—
—
—
0
0
42
332
1.27
0.76
2.3
2.1
130.51
131.54
g/l
0.09
37
268
21
150
1.41
0.73
1.2
1.0
2.88
2.25
eliau/ml
—
9
62
6
109
0.55
0.72
1.2
1.6
—
—
—
0
0
7
40
1.75
0.71
1.9
1.1
88.29
113.20
%
—
7
35
49
399
1.24
0.71
1.5
1.6
1.68
0.09
iu/ml
—
6
75
22
161
1.37
0.68
1.1
1.1
—
1.94
—
0
23
27
352
0.76
0.68
2.9
2.2
21.83
94.84
ug/min
2.04
12
212
5
91
0.55
0.67
1.8
1.6
—
—
—
0
0
156
1725
0.89
0.66
7.0
6.6
—
—
—
0
0
60
506
1.19
0.64
1.5
1.6
29.00
14.56
u/ml
—
9
99
98
861
1.15
0.63
1.3
1.2
120.71
128.84
u/ml
0.08
27
344
5
30
1.67
0.61
2.2
2.5
0.62
0.60
mmol/l
—
5
30
37
298
1.25
0.61
1.3
1.4
52.00
38.56
e6/l
0.15
31
228
144
1302
1.12
0.60
1.4
1.8
1.45
1.50
%
0.64
122
1116
37
301
1.24
0.57
1.4
1.4
1570.59
1016.86
e6/l
0.16
32
244
323
3044
1.08
0.57
1.6
1.8
465.42
28134140.36
pmol/l
2.62
253
2513
23
176
1.31
0.56
3.6
2.4
0.09
0.79
mmol/l
0.38
23
168
26
203
1.29
0.56
1.4
1.9
810.86
3433.53
u/l
—
5
82
6
37
1.62
0.55
1.2
1.1
—
—
—
0
0
41
339
1.22
0.55
1.5
1.3
—
—
—
0
0
6
38
1.58
0.54
1.3
1.5
—
—
—
0
0
9
62
1.45
0.53
5.3
1.5
—
—
—
0
0
9
63
1.43
0.52
1.3
2.0
—
—
—
0
0
11
75
1.47
0.50
1.1
1.1
—
—
—
0
0
60
524
1.15
0.46
1.5
1.6
0.27
0.36
mg/l
0.56
27
227
10
69
1.45
0.44
1.8
2.1
19.40
149.53
ug/min
—
5
17
243
2293
1.07
0.43
3.0
2.9
0.69
0.73
ug/l
0.45
163
1513
5
32
1.56
0.42
5.4
1.8
1.27
1.57
ug/l
—
5
26
92
839
1.10
0.38
1.6
1.9
—
—
—
0
0
13
98
1.33
0.37
1.5
1.2
—
—
—
0
0
5
37
1.35
0.37
1.2
3.0
13.22
9.86
kpa
—
5
37
5
37
1.35
0.37
1.2
3.0
5.19
4.85
kpa
—
5
37
10
72
1.39
0.37
2.3
2.4
—
—
—
0
0
11
146
0.75
0.36
1.4
1.5
—
—
—
0
0
13
99
1.32
0.35
1.1
1.0
—
—
—
0
0
15
117
1.28
0.35
1.1
1.1
—
—
—
0
0
6
43
1.40
0.35
1.2
1.1
—
—
—
0
0
12
91
1.32
0.33
1.7
1.8
146.80
103.43
ng/l
0.64
12
91
19
155
1.23
0.32
1.2
1.0
2.63
0.92
u/ml
—
10
72
83
762
1.09
0.31
1.6
1.9
—
—
—
0
0
16
130
1.23
0.28
1.4
1.5
—
—
—
0
0
138
1302
1.07
0.28
2.6
2.5
4.79
7.58
ug/l
2.20
122
1152
19
226
0.84
0.27
1.3
1.6
1269.26
904.81
mu/l
0.48
13
184
8
65
1.23
0.27
1.5
1.3
—
—
—
0
0
8
66
1.21
0.26
1.0
1.2
—
—
—
0
0
25
288
0.87
0.25
1.1
1.2
176.00
233.40
miu/ml
—
10
131
44
397
1.11
0.25
1.3
1.3
—
—
—
0
0
9
77
1.17
0.24
1.1
1.2
—
—
—
0
0
113
1067
1.06
0.23
1.5
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
21.72
—
0
5
33
296
1.12
0.21
2.8
3.7
32.66
26.26
mg/l
0.40
22
207
12
98
1.23
0.21
1.4
1.2
10.94
9.08
mmol/l
0.67
12
92
15
126
1.19
0.21
1.4
1.6
1.58
1.17
ratio
—
6
83
15
126
1.19
0.21
1.4
1.6
1.00
0.96
ratio
—
6
83
15
126
1.19
0.21
1.4
1.6
0.79
1.18
ratio
—
7
83
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
24
211
1.14
0.20
1.2
1.1
0.09
1.52
u/ml
2.10
12
108
120
1145
1.05
0.19
2.4
2.2
0.28
0.35
e6/l
0.42
112
1082
7
61
1.15
0.17
1.0
1.0
1262.29
1660.59
miu/ml
—
7
61
13
110
1.18
0.17
1.5
1.2
0.08
1.32
u/ml
—
6
60
8
68
1.18
0.16
1.4
6.5
—
70.17
—
0
18
8
68
1.18
0.16
1.1
1.1
—
—
—
0
0
170
1758
0.96
0.16
5.9
5.3
31.54
33.19
%
1.26
127
1123
317
3241
0.97
0.16
4.0
4.2
1.02
1.49
kg/l
0.50
218
2125
8
72
1.11
0.16
1.0
1.0
—
—
—
0
0
7
88
0.79
0.14
1.0
1.6
116.00
84.86
umol/l
—
7
88
37
344
1.08
0.13
1.6
1.8
—
—
—
0
0
189
1844
1.03
0.12
1.4
1.5
—
—
—
0
0
12
105
1.14
0.11
1.8
1.4
—
—
—
0
0
17
188
0.90
0.11
1.2
1.5
—
—
—
0
0
84
810
1.04
0.10
2.6
2.3
12.10
14.63
nmol/l
2.19
71
734
327
3221
1.02
0.10
4.0
4.0
23.18
24.00
%
0.39
162
1535
12
106
1.13
0.09
1.3
1.9
4.68
6.44
umol/l
—
6
65
16
146
1.10
0.08
1.2
1.1
—
—
—
0
0
63
608
1.04
0.08
1.0
1.1
—
—
—
0
0
30
284
1.06
0.07
1.4
1.6
—
—
—
0
0
39
403
0.97
0.04
1.7
1.5
—
—
—
0
0
12
111
1.08
0.04
4.9
3.1
14.31
13.22
%
2.32
12
111
43
418
1.03
0.03
1.7
1.8
—
—
—
0
0
13
122
1.07
0.02
1.1
1.0
0.05
0.24
u/ml
—
6
36
13
122
1.07
0.02
1.1
1.1
—
—
—
0
0
89
878
1.01
0.02
1.3
1.2
161.84
207.80
u/ml
0.36
83
816
33
339
0.97
0.02
1.4
1.5
—
—
—
0
0
21
202
1.04
0.02
3.2
5.2
321.56
354.92
umol/l
0.50
16
176
12
114
1.05
0.00
1.2
1.2
120.25
105.75
pmol/l
0.41
12
114
36
357
1.01
0.00
1.2
2.1
2.36
20.54
iu/l
0.57
12
142
14
135
1.04
0.00
1.2
1.8
—
2720.00
—
0
5
13
125
1.04
0.00
1.5
1.6
—
—
—
0
0
13
135
0.96
0.00
1.5
1.7
64.29
59.90
ug/l
—
7
112
8
79
1.01
0.00
1.1
1.2
—
—
—
0
0
8
80
1.00
-0.00
1.3
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
1.12
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
-0.00
1.8
1.4
183.77
161.76
pmol/l
—
6
66
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
-0.00
1.7
1.9
0.33
3.20
u/field
—
6
46
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
12.28
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
52.60
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
7.56
—
0
7
7
73
0.96
-0.00
3.4
1.9
16.86
18.94
nmol/l
—
7
59
8
80
1.00
-0.00
1.1
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
954.57
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint THROMBOCYTAEMIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| THROMBOCYTAEMIA | 1.67 [1.48, 1.89] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.11 |
During the follow-up period (1.1.1998 — 31.12.2019), 986 out of 3701 females with THROMBOCYTAEMIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| THROMBOCYTAEMIA | 1.754 [1.51, 2.03] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 774 out of 2419 males with THROMBOCYTAEMIA died.
Mortality risk
Mortality risk for people of age
years, who have THROMBOCYTAEMIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.146% | 0.269% |
| 5 | 0.888% | 1.789% |
| 10 | 2.432% | 4.669% |
| 15 | 4.498% | 8.667% |
| 20 | 7.643% | 14.191% |
Relationships between endpoints
↥Index endpoint: THROMBOCYTAEMIA – Essential (haemorrhagic) thrombocythaemia
GWS hits: 16
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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