Biological medicines for asthma

RX_ASTMA_BIOL

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Medicine purchases: ATC R03DX05|R03DX08|R03DX09|R03DX10|D11AH05

1 out of 7 registries used, show all original rules.

934

4. Check minimum number of events

Min. number of events 3
934

5. Include endpoints

None

934

6. Filter based on genotype QC (FinnGen only)

860

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1297 753 538
Only index persons 1280 749 531
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.03 0.02
Median age at first event (years)
Whole population 50.20 49.28 51.58
Only index persons 50.32 49.31 51.75

-FinnGen-

Key figures

All Female Male
Number of individuals 860 545 315
Unadjusted period prevalence (%) 0.18 0.19 0.14
Median age at first event (years) 55.67 54.47 57.75

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
892
Matched controls
8920
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
16.7
311.2
305
269
R03AK08
ATC
formoterol and beclometasone; inhalant
18.4
309.4
282
219
D11AH05
ATC
dupilumab; topical
7912.2
307.7
439
*
J45.0
ICD-10 Finland
Predominantly allergic asthma
16.3
307.7
435
491
395
Kela drug reimbursment
Dupilumab
6855.0
307.7
406
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
17.5
307.7
621
1032
J45.9
ICD-10 Finland
Asthma, unspecified
12.7
307.7
556
1029
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
29.8
307.7
242
110
R03DC03
ATC
montelukast; oral
25.9
307.7
687
1022
J33.0
ICD-10 Finland
Polyp of nasal cavity
31.7
307.7
248
107
ZX112
NOMESCO Finland
Subcutaneous
50.7
307.7
225
59
R03BB04
ATC
tiotropium bromide; inhalant
20.9
307.7
388
317
J45.1
ICD-10 Finland
Nonallergic asthma
17.1
307.7
335
303
J32.4
ICD-10 Finland
Chronic pansinusitis
60.0
307.7
222
49
H02AB06
ATC
prednisolone; systemic
38.5
277.7
849
3025
J33.8
ICD-10 Finland
Other polyp of sinus
31.5
270.9
184
73
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
30.0
253.9
175
72
J46
ICD-10 Finland
Status asthmaticus
24.3
253.2
191
99
R03DX05
ATC
omalizumab; parenteral
+∞
249.0
227
*
344
Kela drug reimbursment
Omalizumab
+∞
242.0
221
*
D11AH01
ATC
tacrolimus; topical
49.1
238.9
141
34
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
14.1
235.2
245
233
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
10.7
231.2
313
430
DHB20
NOMESCO Finland
Polypectomy of internal nose
41.3
227.1
140
40
UDH02
NOMESCO Finland
Rhinopharyngoscopy
11.3
224.2
281
348
XG474
NOMESCO Finland
Exhalation nntrogen oxide
18.8
219.1
186
123
J45
ICD-10 Finland
Asthma
9.2
214.8
339
557
GX1L5
NOMESCO Finland
Exhaled nitric oxide analysis
42.5
209.7
128
35
XQ800
NOMESCO Finland
Prick test
9.8
202.2
286
410
R03DX09
ATC
mepolizumab; parenteral
+∞
199.7
184
*
L50.1
ICD-10 Finland
Idiopathic urticaria
52.7
192.0
111
24
3028
Kela drug reimbursment
Mepolizumab
2331.5
190.7
178
*
R06AX27
ATC
desloratadine; oral
7.3
183.2
624
2153
297, ,
Kela drug reimbursment
+∞
179.4
166
*
R03AK11
ATC
formoterol and fluticasone; inhalant
21.9
178.6
138
74
TDM10
NOMESCO Finland
Puncture of maxillary antrum
13.0
177.6
188
180
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
17.4
175.7
153
105
R03AK06
ATC
salmeterol and fluticasone; inhalant
7.4
175.2
339
681
R03DA04
ATC
theophylline; systemic, rectal
16.0
175.1
160
120
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
15.0
173.2
165
133
J45.8
ICD-10 Finland
Mixed asthma
16.9
173.0
153
108
L20.0
ICD-10 Finland
Besnier prurigo
8.2
172.7
287
490
R03BA08
ATC
ciclesonide; inhalant
8.1
168.3
279
474
R01AD08
ATC
fluticasone; nasal
6.4
167.1
569
1921
L50.8
ICD-10 Finland
Other urticaria
21.9
165.3
127
67
R96
ICPC
Asthma
8.1
160.8
264
442
R03BA02
ATC
budesonide; inhalant
6.3
160.7
402
1025
D11AH02
ATC
pimecrolimus; topical
52.6
155.9
90
19
C01CA24
ATC
epinephrine; parenteral
8.3
155.0
242
382
R06AE09
ATC
levocetirizine; oral
6.3
153.6
364
878
R03AC13
ATC
formoterol; inhalant
11.4
143.1
163
172
DPA25
NOMESCO Finland
Trephine of frontal sinus through nose
28.5
141.5
97
38
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
24.9
141.2
102
46
DPA30
NOMESCO Finland
Sphenotomy
36.5
136.1
86
26
L50.9
ICD-10 Finland
Urticaria, unspecified
10.2
133.6
165
194
L04AD01
ATC
ciclosporin; systemic
18.6
133.4
110
67
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
10.9
128.5
150
163
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
10.1
125.0
154
180
H02AB04
ATC
methylprednisolone; systemic
5.8
124.5
297
706
R03AK07
ATC
formoterol and budesonide; inhalant
5.0
124.2
425
1367
R03DX10
ATC
benralizumab; systemic
+∞
123.9
116
*
R03AC02
ATC
salbutamol; inhalant
8.3
123.4
781
4093
D11AX14
ATC
[U] tacrolimus
48.1
120.8
71
16
H02AB07
ATC
prednisone; oral
6.0
120.7
271
608
3027
Kela drug reimbursment
Benralizumab
+∞
120.6
113
*
R03BA05
ATC
fluticasone; inhalant
5.1
118.3
361
1053
J33.9
ICD-10 Finland
Nasal polyp, unspecified
22.6
117.6
88
43
R03AC12
ATC
salmeterol; inhalant
11.7
116.3
127
125
251, ,
Kela drug reimbursment
+∞
116.2
109
*
UDM02
NOMESCO Finland
Sinoscopy
13.8
116.0
113
93
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
10.9
110.7
127
134
R06AE07
ATC
cetirizine; oral
4.9
106.3
651
3151
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
5.7
105.4
239
536
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
8.5
104.7
148
204
R06AX22
ATC
ebastine; oral
4.6
101.5
340
1050
TQW80
NOMESCO Finland
Local dermatologic skincare
12.8
98.9
100
87
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
33.2
95.8
62
20
R01AD58
ATC
fluticasone, combinations; nasal
4.0
90.8
457
1864
D07AB08
ATC
desonide; topical
5.1
90.0
229
562
XQ802
NOMESCO Finland
Epicutan test
7.6
86.8
133
200
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
7.6
85.4
131
197
XG410
NOMESCO Finland
Flow-volume spirometry
9.3
84.8
108
130
49300
ICD-8 Finland
Asthma, bronchiale
13.2
84.2
83
69
D02AE01
ATC
carbamide; topical
6.6
82.3
146
256
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
5.7
81.9
175
367
R03BA01
ATC
beclometasone; inhalant
4.5
79.7
243
684
H02AB09
ATC
hydrocortisone; systemic
11.8
77.6
82
76
E0000UV, ,
ATC
3.6
76.7
557
2797
D07AC01
ATC
betamethasone; topical
3.5
75.6
489
2278
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.6
75.3
549
2753
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
11.2
74.9
82
80
L04AX03
ATC
methotrexate; systemic
4.8
73.7
199
507
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
4.3
73.6
240
707
D07BA04
ATC
hydrocortisone and antiseptics; topical
4.8
73.3
197
500
R03AC03
ATC
terbutaline; inhalant
4.2
72.7
246
744
WZC30
NOMESCO Finland
Teaching
4.0
72.0
265
851
Z88.6
ICD-10 Finland
Personal history of allergy to analgesic agent
260.7
71.4
72
*
R01AD12
ATC
fluticasone furoate; nasal
3.4
70.9
491
2360
D07AA02
ATC
hydrocortisone; topical
3.9
70.1
263
854
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.8
69.8
141
279
Z51.6
ICD-10 Finland
Desensitization to allergens
15.1
68.7
62
44
D02AX
ATC
Other emollients and protectives
9.1
67.9
87
105
R01AD05
ATC
budesonide; nasal
5.0
67.0
164
384
R01AD09
ATC
mometasone; nasal
3.5
66.8
611
3428
R06AX13
ATC
loratadine; oral
3.7
64.9
273
953
R06AX26
ATC
fexofenadine; oral
4.7
62.1
163
403
R03DC01
ATC
zafirlukast; oral
14.0
61.9
58
44
J32.2
ICD-10 Finland
Chronic ethmoidal sinusitis
22.0
61.5
46
22
D09AB01
ATC
zinc bandage without supplements; topical
13.4
60.3
58
46
J01MA14
ATC
moxifloxacin; systemic
4.7
58.5
152
372
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
13.9
58.4
55
42
L50.3
ICD-10 Finland
Dermatographic urticaria
9.7
57.9
70
78
E000003, ,
ATC
6.1
57.9
108
197
E000002, ,
ATC
4.0
56.8
195
588
ZXC95
NOMESCO Finland
Use of surgical navigator
14.0
56.6
53
40
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
3.7
56.4
225
751
R02
ICPC
Shortness of breath/dyspnoea
3.9
56.2
202
628
ZXA10
NOMESCO Finland
Bilateral
3.6
56.2
237
820
J33
ICD-10 Finland
Nasal polyp
17.1
55.9
47
29
E000001, ,
ATC
3.3
55.4
291
1153
D07AB02
ATC
hydrocortisone butyrate; topical
3.0
54.7
390
1837
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
5.6
54.7
111
219
D07AD01
ATC
clobetasol; topical
3.5
54.4
243
871
XQ848
NOMESCO Finland
Dermatological photography
8.1
54.2
76
102
D07AC13
ATC
mometasone; topical
3.0
53.5
370
1710
L50
ICD-10 Finland
Urticaria
9.0
53.4
68
81
S01GX01
ATC
cromoglicic acid; ophthalmic
3.1
52.6
317
1354
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.9
51.8
386
1851
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
8.0
51.1
72
97
L20
ICD-10 Finland
Atopic dermatitis
6.2
51.0
92
162
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.1
50.4
277
1119
N05BB01
ATC
hydroxyzine; systemic
4.9
50.2
121
277
L27.2
ICD-10 Finland
Dermatitis due to ingested food
14.3
48.8
45
33
J47
ICD-10 Finland
Bronchiectasis
12.3
48.4
49
42
J30.3
ICD-10 Finland
Other allergic rhinitis
5.6
48.2
98
193
J01FA06
ATC
roxithromycin; oral
2.7
47.5
460
2498
L28.1
ICD-10 Finland
Prurigo nodularis
17.7
47.3
39
23
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
16.3
45.4
39
25
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.2
45.1
133
356
WQ000
NOMESCO Finland
Hyposensibilisation
15.8
43.6
38
25
R01AD01
ATC
beclometasone; nasal
3.1
43.3
228
890
DHB50
NOMESCO Finland
Turbinoplasty
6.5
42.7
72
118
J01FA10
ATC
azithromycin; systemic
2.9
42.6
671
4547
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.7
41.9
607
3927
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
3.5
41.6
167
552
J01AA02
ATC
doxycycline; systemic
3.6
41.5
770
5668
J31.0
ICD-10 Finland
Chronic rhinitis
3.6
40.4
156
502
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.8
40.2
262
1144
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
10.5
40.1
45
45
S87
ICPC
Dermatitis/atopic eczema
6.6
39.5
66
107
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.6
39.2
101
243
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.6
38.8
327
1621
R06.0
ICD-10 Finland
Dyspnoea
2.7
38.5
301
1437
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
9.3
38.4
47
53
J01FA09
ATC
clarithromycin; systemic
2.4
36.2
382
2089
T78.4
ICD-10 Finland
Allergy, unspecified
4.5
35.1
92
224
H65.3
ICD-10 Finland
Chronic mucoid otitis media
6.2
34.7
61
104
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.4
34.5
415
2391
R01AD11
ATC
triamcinolone; nasal
3.4
34.3
137
448
134
Kela drug reimbursment
General erythroderma
43.9
34.3
42
10
R01BA52
ATC
pseudoephedrine, combinations; oral
2.4
34.1
343
1824
E000007, ,
ATC
4.1
33.7
100
267
D72.1
ICD-10 Finland
Eosinophilia
36.6
33.1
42
12
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
10.4
32.9
37
37
DJD20
NOMESCO Finland
Plastic repair of septum of nose
4.9
32.1
74
162
XG405
NOMESCO Finland
Education on PEF monitoring
10.1
31.4
36
37
J01MA12
ATC
levofloxacin; systemic
2.8
31.1
194
817
D11AX15
ATC
[U] pimecrolimus
48.1
30.8
37
8
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.7
30.7
74
168
T78.3
ICD-10 Finland
Angioneurotic oedema
9.4
30.5
37
41
S01GX08
ATC
ketotifen; ophthalmic
4.1
30.4
89
235
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
33.9
30.2
39
12
J01FA15
ATC
telithromycin; oral
3.1
29.8
142
515
J34.2
ICD-10 Finland
Deviated nasal septum
3.8
29.5
97
278
TGC00
NOMESCO Finland
Bronchial lavation
6.5
29.4
49
79
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.9
29.4
91
250
3DX05, ,
NOMESCO Finland
+∞
29.3
28
*
A02BC05
ATC
esomeprazole; systemic
2.2
29.0
416
2528
D07BC01
ATC
betamethasone and antiseptics; topical
3.0
29.0
148
558
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
28.5
258
1293
J01DC02
ATC
cefuroxime; systemic
3.8
28.4
91
256
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
10.3
28.4
32
32
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.4
28.2
259
1304
E000006, ,
ATC
3.6
28.0
99
298
J01FF01
ATC
clindamycin; systemic
2.3
27.8
296
1588
R03BB01
ATC
ipratropium bromide; inhalant
6.6
27.6
45
71
L04AA01
ATC
[U] ciclosporin
10.7
27.2
30
29
J01DB01
ATC
cefalexin; oral
3.3
26.8
806
6587
R06.2
ICD-10 Finland
Wheezing
4.1
26.4
76
198
GD1AD
NOMESCO Finland
Thorax CT examination
3.8
26.2
85
241
R03DX11
ATC
tezepelumab; systemic
+∞
26.2
25
*
L50.0
ICD-10 Finland
Allergic urticaria
5.2
25.9
55
112
R03BC03
ATC
nedocromil; inhalant
3.5
25.7
95
294
L04AX01
ATC
azathioprine; systemic
4.3
25.5
68
167
R01AD59
ATC
mometasone, combinations; nasal
3.0
24.6
121
445
D07AC14
ATC
methylprednisolone aceponate; topical
3.9
24.4
74
200
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
8.1
24.4
33
42
A02BC02
ATC
pantoprazole; systemic
2.2
24.3
637
4755
DPW99
NOMESCO Finland
Other operation on frontal or sphenoidal sinus
69.4
23.9
27
*
DHA10
NOMESCO Finland
Biopsy of cavity of nose
9.9
23.3
27
28
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.2
23.2
100
340
J33.1
ICD-10 Finland
Polypoid sinus degeneration
85.7
22.8
25
*
R03BB07
ATC
umeclidinium bromide; inhalant
19.6
22.7
34
18
D07CC01
ATC
betamethasone and antibiotics; topical
2.5
22.0
154
678
R06AX18
ATC
acrivastine; oral
5.0
21.7
48
101
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
4.2
21.2
58
145
J02AC01
ATC
fluconazole; systemic
2.0
21.2
415
2738
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.0
20.8
298
1760
N02AJ06
ATC
codeine and paracetamol; systemic
1.9
20.7
448
3048
G47.3
ICD-10 Finland
Sleep apnoea
2.1
20.4
256
1437
WW200
NOMESCO Finland
Immunization
4.8
20.3
47
103
A07AA02
ATC
nystatin; oral
3.7
20.1
67
193
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
27.8
20.1
27
10
D07XC01
ATC
betamethasone; topical
2.6
20.0
132
564
GX1E5
NOMESCO Finland
Flow volume spirometry and bronchodilation test
18.2
19.7
30
17
L26
ICD-10 Finland
Exfoliative dermatitis
107.4
19.6
21
*
J01DA01
ATC
[U] cefalexin
2.0
19.6
580
4348
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
4.5
19.5
49
115
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.1
19.3
230
1264
A92
ICPC
Allergy/allergic reaction NOS
3.8
19.0
60
167
N02AX02
ATC
tramadol; systemic, rectal
1.9
18.5
394
2637
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
18.5
264
1546
R05
ICD-10 Finland
Cough
2.1
18.4
231
1290
4930B
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA CUM EXACERBATIONE]
16.6
18.4
29
18
T78.2
ICD-10 Finland
Anaphylactic shock, unspecified
6.1
17.9
31
52
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
17.8
139
640
4222
FHL
Endonasal etmoidectomy
20.6
17.8
26
13
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
6.9
17.5
27
40
O99.5
ICD-10 Finland
Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium
7.9
17.5
24
31
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
4.9
17.4
39
83
H65.2
ICD-10 Finland
Chronic serous otitis media
6.3
17.3
29
47
J32.8
ICD-10 Finland
Other chronic sinusitis
17.8
17.0
26
15
D07XB05
ATC
dexamethasone; topical
4.5
16.5
41
95
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.9
16.5
295
1851
J02AC02
ATC
itraconazole; systemic
2.1
16.5
178
936
UDC00
NOMESCO Finland
Ear microscopy
2.9
16.5
83
308
SPAT1254
SPAT
Administration of medicine
2.3
16.3
133
624
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
4.7
16.2
38
84
S01AD03
ATC
aciclovir; ophthalmic
4.0
15.9
46
120
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.7
15.9
88
343
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
4.2
15.8
43
107
J82
ICD-10 Finland
Pulmonary eosinophilia, not elsewhere classified
61.1
15.8
18
*
A02BA02
ATC
ranitidine; systemic
2.2
15.6
157
802
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.8
15.6
568
4391
TQX05
NOMESCO Finland
Skin puncture, unspecified location
29.2
15.2
20
7
4711A
ICD-9 Finland
Nasal polyps, Polypoid sinus degeneration
23.9
15.2
21
9
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
2.7
15.0
84
329
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
4.1
15.0
42
107
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
15.0
413
2934
R05
ICPC
Cough
1.9
14.9
258
1594
J01MA02
ATC
ciprofloxacin; systemic
1.8
14.9
323
2140
E000004, ,
ATC
5.0
14.8
32
66
J04BA02
ATC
dapsone; oral
18.8
14.7
22
12
J01.1
ICD-10 Finland
Acute frontal sinusitis
4.4
14.4
36
84
N02BE01
ATC
paracetamol; systemic, rectal
2.5
14.4
807
7090
XQ820
NOMESCO Finland
Exposure to medicinal substance
17.3
14.3
22
13
D07CB01
ATC
triamcinolone and antibiotics; topical
5.2
14.2
29
57
3029
Kela drug reimbursment
Upadacitinib
14.7
14.1
23
16
J05AB01
ATC
aciclovir; systemic
1.9
14.0
219
1305
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
14.0
306
2022
J01DA08
ATC
[U] cefaclor
2.1
13.9
141
720
D07AB01
ATC
clobetasone; topical
3.9
13.9
42
113
L04AF03
ATC
upadacitinib; oral
24.2
13.8
19
8
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.8
13.8
249
1554
H10.1
ICD-10 Finland
Acute atopic conjunctivitis
3.6
13.6
45
129
L30.3
ICD-10 Finland
Infective dermatitis
3.4
13.6
49
149
3089, ,
Kela drug reimbursment
+∞
13.6
13
*
L20.8
ICD-10 Finland
Other atopic dermatitis
5.1
13.4
28
56
R03AK03
ATC
[U] fenoterol and ipratropium bromide
3.8
13.3
41
112
J01CA04
ATC
amoxicillin; systemic
2.1
13.2
772
6714
A02BC01
ATC
omeprazole; systemic
1.8
13.2
231
1425
XG404
NOMESCO Finland
Peak expiratory flow (PEF) measurement
15.3
13.1
21
14
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
4.7
13.1
30
65
R03BC01
ATC
cromoglicic acid; inhalant
4.7
13.1
30
65
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
13.0
233
1446
A46
ICD-10 Finland
Erysipelas
2.2
12.8
122
607
J05AB11
ATC
valaciclovir; oral
2.0
12.8
151
815
49302
ICD-8 Finland
Asthma, Rhinitis allergica cum asthmate bronchiali
14.3
12.8
21
15
4730A
ICD-9 Finland
Chronic sinusitis, Maxillary
5.2
12.7
26
51
ZX114
NOMESCO Finland
Intramuscular
5.0
12.7
27
55
J34.3
ICD-10 Finland
Hypertrophy of nasal turbinates
4.0
12.6
36
93
SPAT1058
SPAT
PEF monitoring instruction
2.6
12.6
77
315
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.2
12.6
108
515
J01.9
ICD-10 Finland
Acute sinusitis, unspecified
2.8
12.6
65
244
4AC06, ,
NOMESCO Finland
+∞
12.5
12
*
J20
ICD-10 Finland
Acute bronchitis
2.2
12.2
117
584
S02
ICPC
Pruritus
3.2
12.1
49
160
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
27.1
12.1
16
6
J01DA09
ATC
[U] cefadroxil
1.8
12.0
251
1625
H66.9
ICD-10 Finland
Otitis media, unspecified
2.4
12.0
90
405
M05BA04
ATC
alendronic acid; oral
2.8
12.0
62
233
M79.6
ICD-10 Finland
Pain in limb
1.7
12.0
408
3011
4224
FHL
Endonasal anthrostomy
5.9
11.8
21
36
S88
ICPC
Dermatitis contact/allergic
4.0
11.8
33
84
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.6
11.8
70
283
B00.10
ICD-10 Finland
Herpes simplex facialis
5.6
11.7
22
40
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
4.3
11.6
30
72
DHB40
NOMESCO Finland
Conchotomy
23.2
11.6
16
7
DMB00
NOMESCO Finland
Endonasal trephine of maxillary antrum
8.8
11.6
24
28
S98
ICPC
Urticaria
10.2
11.5
22
22
A02BC03
ATC
lansoprazole; oral
1.8
11.5
238
1535
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.7
11.5
282
1907
J30.4
ICD-10 Finland
Allergic rhinitis, unspecified
2.8
11.3
58
217
DMB10
NOMESCO Finland
Radical maxillary antrotomy
17.3
11.2
17
10
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
11.2
396
2935
GX2C5
NOMESCO Finland
Short-lasting oximetry
12.9
11.2
19
15
J30.0
ICD-10 Finland
Vasomotor rhinitis
3.7
11.2
35
97
R01AD
ATC
Corticosteroids
8.2
11.1
24
30
R78
ICPC
Acute bronchitis/bronchiolitis
4.0
11.1
31
79
R5140
NOMESCO Finland
Monitoring the use of the aid
2.1
11.0
112
572
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
3.8
10.9
33
89
R60.9
ICD-10 Finland
Oedema, unspecified
2.8
10.9
54
199
S01
ICPC
Pain/tenderness of skin
2.9
10.8
52
188
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
4.4
10.8
27
63
J01.4
ICD-10 Finland
Acute pansinusitis
5.7
10.7
20
36
R81
ICPC
Pneumonia
3.2
10.7
43
140
J40
ICD-10 Finland
Bronchitis, not specified as acute or chronic
3.4
10.6
39
120
Z3231
NOMESCO Finland
Registered nurse
1.7
10.6
234
1531
B07.9
ICD-10 Finland
Verruca simplex
2.9
10.5
49
174
WXQ26
NOMESCO Finland
UVB broad spectrum light therapy
+∞
10.4
10
*
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.6
10.4
322
2299
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
4.0
10.4
29
74
ZX110
NOMESCO Finland
Intracutaneous
32.9
10.3
13
*
R03AK
ATC
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
19.0
10.3
15
8
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
10.3
345
2511
M81.4
ICD-10 Finland
Drug-induced osteoporosis
13.3
10.2
17
13
DFF00
NOMESCO Finland
Pure tone audiometry
2.2
10.1
88
422
GD1AA, ,
SPAT
1.8
10.1
186
1155
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
12.4
9.9
17
14
H04.10
ICD-10 Finland
Dry eye syndrome
2.0
9.7
120
656
R06AX12
ATC
terfenadine; oral
2.7
9.7
52
200
S01GX02
ATC
levocabastine; ophthalmic
2.4
9.6
68
298
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.1
9.6
97
493
Z71.8
ICD-10 Finland
Other specified counselling
1.6
9.6
332
2425
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
4.9
9.6
21
44
L29.9
ICD-10 Finland
Pruritus, unspecified
3.4
9.5
34
103
H66
ICD-10 Finland
Suppurative and unspecified otitis media
3.4
9.5
34
103
J01DA06
ATC
[U] cefuroxime
1.9
9.5
141
819
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.8
9.5
176
1094
3006
Kela drug reimbursment
Baricitinib
17.8
9.4
14
8
XG488
NOMESCO Finland
Other provokation of respiratroy tract
30.4
9.4
12
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.1
9.4
94
477
X58
ICD-10 Finland
Exposure to other specified factors
1.8
9.3
157
950
I45.9
ICD-10 Finland
Conduction disorder, unspecified
13.8
9.2
15
11
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
9.2
181
1143
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.7
9.2
48
182
R49.08
ICD-10 Finland
Other specified dysphonia
3.6
9.1
30
86
V01AA02
ATC
grass pollen; parenteral
15.8
9.0
14
9
DPA20
NOMESCO Finland
Trephine of frontal sinus
15.8
9.0
14
9
UJF32
NOMESCO Finland
Coloscopy
1.7
9.0
195
1263
ZXE00
NOMESCO Finland
One hour or less
1.6
8.7
326
2410
R75
ICPC
Sinusitis acute/chronic
2.4
8.7
61
267
WX002
NOMESCO Finland
Sedation and analgesia
1.8
8.7
149
904
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.3
8.6
63
281
L50.2
ICD-10 Finland
Urticaria due to cold and heat
16.5
8.6
13
8
L08.0
ICD-10 Finland
Pyoderma
10.2
8.5
16
16
4226
FHL
Posterior radical surgery and possible etmoidectomy
10.2
8.5
16
16
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.3
8.4
66
303
L50.5
ICD-10 Finland
Cholinergic urticaria
+∞
8.3
8
*
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
8.3
175
1123
S01GX04
ATC
nedocromil; ophthalmic
3.9
8.3
24
63
J01DB05
ATC
cefadroxil; oral
2.6
8.3
48
192
R51.80
ICD-10 Finland
Headache
1.7
8.3
167
1060
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
14.6
8.2
13
9
N03AX12
ATC
[U] gabapentin; oral
1.8
8.2
139
840
L03.9
ICD-10 Finland
Cellulitis, unspecified
3.6
8.2
26
73
R03AL08
ATC
vilanterol, umeclidinium bromide and fluticasone furoate; inhalant
4.6
8.1
19
42
R05FA02
ATC
opium derivatives and expectorants; systemic
1.5
8.1
322
2403
S01BA01
ATC
dexamethasone; ophthalmic
3.1
8.1
34
114
A01AB09
ATC
miconazole; local oral
2.2
8.1
71
342
N06AX11
ATC
mirtazapine; oral
1.5
8.1
299
2199
WX110
NOMESCO Finland
Infiltration anesthesia
1.6
8.0
664
5780
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.6
8.0
219
1501
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
3.9
8.0
23
60
R74
ICPC
Upper respiratory infection acute
1.5
8.0
358
2740
J37.0
ICD-10 Finland
Chronic laryngitis
2.9
8.0
38
137
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
8.0
172
1111
N06AX26
ATC
vortioxetine; oral
2.0
7.9
88
463
R60.0
ICD-10 Finland
Localized oedema
1.9
7.9
96
521
Z01.7
ICD-10 Finland
Laboratory examination
1.7
7.9
160
1015
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
7.9
116
670
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.7
7.9
41
155
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
4.7
7.9
18
39
H10.5
ICD-10 Finland
Blepharoconjunctivitis
3.4
7.8
27
80
SPAT1059
SPAT
Spirometry at the office
2.6
7.8
45
180
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.9
7.7
98
540
DNB10
NOMESCO Finland
Endonasal ethmoidectomy
45.4
7.7
9
*
B37.0
ICD-10 Finland
Candidal stomatitis
6.0
7.7
20
34
A02BC04
ATC
rabeprazole; oral
2.0
7.6
89
477
A03
ICPC
Fever
1.6
7.6
183
1214
L01.1
ICD-10 Finland
Impetiginization of other dermatoses
9.0
7.6
15
17
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.4
7.5
51
220
H10
ICD-10 Finland
Conjunctivitis
2.0
7.5
83
436
J01XC01
ATC
fusidic acid; systemic
4.3
7.5
19
45
V01AA05
ATC
tree pollen; parenteral
6.5
7.4
18
28
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.7
7.4
138
855
WX402
NOMESCO Finland
General anaesthesia
1.6
7.4
202
1381
3023
Kela drug reimbursment
Allergen extract of birch pollen (adults)
13.5
7.4
12
9
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.9
7.4
89
482
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.8
7.4
112
654
1543, ,
Kela drug reimbursment
+∞
7.3
7
*
4931A
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA SINE EXACERBATIONE]
9.5
7.3
14
15
T88.7
ICD-10 Finland
Unspecified adverse effect of drug or medicament
3.9
7.3
21
55
T78.0
ICD-10 Finland
Anaphylactic shock due to adverse food reaction
15.9
7.2
11
7
SPAT1255
SPAT
Intravenous administration of medicine
2.3
7.2
53
237
H26.3
ICD-10 Finland
Drug-induced cataract
7.4
7.2
16
22
WVA20
NOMESCO Finland
Medicine administration
2.9
7.2
33
117
N06AX12
ATC
bupropion; oral
1.9
7.2
89
487
T88.6
ICD-10 Finland
Anaphylactic shock due to adverse effect of correct drug or medicament properly administered
20.2
7.1
10
5
L95.8
ICD-10 Finland
Other vasculitis limited to skin
20.2
7.1
10
5
J32.1
ICD-10 Finland
Chronic frontal sinusitis
6.6
7.1
17
26
R03BA07
ATC
mometasone; inhalant
6.6
7.1
17
26
J39.9
ICD-10 Finland
Disease of upper respiratory tract, unspecified
12.1
7.1
12
10
L71.9
ICD-10 Finland
Rosacea, unspecified
3.0
7.0
30
102
H01.0
ICD-10 Finland
Blepharitis
2.0
7.0
75
390
J01
ICD-10 Finland
Acute sinusitis
2.1
7.0
62
300
B00.0
ICD-10 Finland
Eczema herpeticum
7.6
6.9
15
20
4221
FHL
Polyp removal from the nasal cavity, sinus puncture or irrigation, or biopsy under general anesthesia or operating room
7.6
6.9
15
20
R01AC07
ATC
nedocromil; nasal
13.9
6.9
11
8
SPAT1263
SPAT
Sampling
1.5
6.9
342
2653
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
2.0
6.9
75
393
ZYC01
NOMESCO Finland
Remote contact by phone
2.1
6.9
66
330
C09CA06
ATC
candesartan; oral
1.6
6.8
203
1413
WX780
NOMESCO Finland
Remote monitoring CPAP
2.3
6.8
51
230
S18
ICPC
Laceration/cut
1.5
6.8
380
3012
R09
ICPC
Sinus symptom/complaint
1.9
6.8
91
510
D06AX01
ATC
fusidic acid; topical
1.9
6.8
88
488
R83
ICPC
Respiratory infection other
1.5
6.8
273
2030
4732A
ICD-9 Finland
Chronic sinusitis, Ethmoidal
40.4
6.8
8
*
4931B
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA CUM EXACERBATIONE]
16.8
6.8
10
6
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.7
6.7
123
758
M03BX02
ATC
tizanidine; oral
1.5
6.7
561
4794
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.5
6.6
236
1709
SFC01
NOMESCO Finland
Additional procedure necessary for restorative treatment
1.5
6.6
241
1753
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.2
6.6
54
253
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.4
6.6
500
4188
K30
ICD-10 Finland
Functional dyspepsia
1.8
6.6
105
622
J01DC04
ATC
cefaclor; oral
3.9
6.6
19
50
H03.1*B00.5
ICD-10 Finland
Herpesviral dermatitis of eyelid
10.1
6.5
12
12
R29
ICPC
Respiratory symptom/complaint other
2.0
6.5
70
364
R06AE08, ,
ATC
5.4
6.5
18
34
UJF30
NOMESCO Finland
Ileoscopy through colon
1.9
6.5
89
504
H25.8
ICD-10 Finland
Other senile cataract
2.2
6.4
51
236
B44.1
ICD-10 Finland
Other pulmonary aspergillosis
70.3
6.4
7
*
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
6.4
200
1407
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.7
6.4
112
682
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
4.1
6.4
17
42
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
8.2
6.3
13
16
R49.8
ICD-10 Finland
Other and unspecified voice disturbances
5.6
6.3
17
31
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
6.3
152
1006
WX722
NOMESCO Finland
PEEP
2.5
6.3
39
162
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
18.2
6.3
9
5
3DX08, ,
NOMESCO Finland
+∞
6.3
6
*
R01AC01
ATC
cromoglicic acid; nasal
2.3
6.2
45
200
R05CB01
ATC
acetylcysteine; inhalant, oral
7.1
6.2
14
20
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
1.9
6.2
73
392
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
2.4
6.2
40
169
R07
ICPC
Sneezing/nasal congestion
1.9
6.2
75
407
N06AX21
ATC
duloxetine; oral
1.7
6.1
114
705
SFA20
NOMESCO Finland
Two-surface restoration
1.4
6.1
545
4671
JN3AD
NOMESCO Finland
Abdominal CT examination
1.7
6.1
107
652
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.5
6.1
278
2112
J98.0
ICD-10 Finland
Diseases of bronchus, not elsewhere classified
10.1
6.0
11
11
L04AA44
ATC
[U] upadacitinib
10.1
6.0
11
11

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
252
73
47.72
307.65
1.7
1.1
2.09
0.48
u/ml
1.72
191
34
719
669
51.26
307.65
3.0
1.3
857.57
224.76
u/ml
7.89
711
623
247
238
13.97
235.11
1.3
1.1
4.05
2.07
u/ml
0.95
183
125
219
206
13.77
210.65
1.3
1.1
3.61
5.56
u/ml
0.82
156
116
231
265
11.41
193.37
1.4
1.2
—
—
—
0
0
206
202
12.96
192.14
1.3
1.1
3.57
1.41
u/ml
1.63
155
103
870
4123
46.01
186.62
11.8
6.7
0.60
0.56
e9/l
7.11
831
3588
870
4131
45.84
185.99
11.8
6.7
0.05
0.04
e9/l
7.19
829
3595
199
198
12.65
183.49
1.3
1.1
1.55
0.72
u/ml
0.90
134
83
685
2586
8.11
182.15
9.8
6.8
—
—
—
0
0
877
4269
63.70
180.89
12.6
7.0
0.33
0.19
e9/l
33.97
843
3779
871
4224
46.11
179.53
11.9
6.7
1.99
1.97
e9/l
0.14
835
3767
806
3895
12.09
154.95
11.7
6.7
27.90
28.95
%
2.69
806
3723
172
183
11.41
150.37
1.3
1.0
8.14
3.25
u/ml
2.27
135
95
863
4567
28.36
148.93
12.1
9.8
4.15
3.99
e9/l
1.73
823
4005
162
168
11.56
143.98
1.3
1.1
6.15
6.44
u/ml
0.05
120
72
120
90
15.25
130.39
3.6
2.6
—
—
—
0
0
149
158
11.12
129.96
1.2
1.0
0.69
0.24
u/ml
0.87
98
50
285
811
4.69
93.64
3.0
2.1
279.54
377.98
nmol/l
16.06
277
768
252
676
4.80
88.76
5.3
4.9
0.36
0.66
%
1.32
62
188
249
669
4.78
87.41
5.6
5.2
0.05
0.14
%
0.84
57
168
92
85
11.95
87.36
1.4
1.3
2.78
2.92
g/l
0.30
75
63
92
85
11.95
87.36
1.4
1.3
6.20
6.58
g/l
0.40
75
64
92
85
11.95
87.36
1.4
1.3
0.31
0.33
g/l
0.22
75
64
91
85
11.81
85.77
1.5
1.3
—
—
—
0
0
249
682
4.68
85.12
6.0
5.5
0.02
0.13
%
1.34
53
153
293
912
4.30
84.59
2.5
1.6
—
—
—
0
0
253
705
4.61
84.55
5.6
5.0
0.61
1.01
%
1.08
61
205
239
676
4.46
77.77
2.7
2.7
10.07
10.54
g/l
1.05
227
632
144
274
6.07
74.44
1.7
1.6
0.24
0.24
g/l
0.10
139
263
105
145
8.07
73.47
1.9
1.8
1.30
0.81
g/l
1.91
86
120
73
64
12.33
71.48
1.3
1.5
6.06
6.42
ug/l
0.17
68
54
333
1283
3.55
68.39
1.5
1.4
334.74
496.61
titre
1.64
57
277
148
314
5.45
67.77
1.5
1.3
—
—
—
0
0
277
952
3.77
67.70
2.0
1.5
—
—
—
0
0
443
2055
3.30
66.81
8.2
4.8
—
—
—
0
0
47
21
23.57
64.58
1.2
1.0
1.42
3.42
u/ml
0.30
37
16
621
3607
3.38
62.21
15.8
10.7
0.00
0.00
e9/l
0.94
553
2966
46
24
20.15
59.22
1.1
1.1
2.19
1.12
u/ml
0.60
30
12
278
1037
3.44
58.88
2.7
3.4
4.03
5.44
e9/l
1.53
264
936
187
534
4.17
58.85
1.7
1.8
1.06
1.31
g/l
2.03
173
504
60
64
9.98
51.20
1.2
1.0
7.15
0.54
u/ml
1.10
38
16
47
35
14.12
50.54
1.2
1.1
9.07
15.07
u/ml
—
19
7
252
982
3.18
48.54
2.0
1.4
—
—
—
0
0
55
61
9.54
45.54
1.2
1.0
15.67
0.34
u/ml
0.99
33
23
256
1044
3.04
45.18
2.2
2.1
—
—
—
0
0
52
61
8.99
41.21
1.2
1.0
—
—
—
0
0
363
1893
2.55
38.69
1.8
1.5
2.24
2.29
g/l
0.28
275
1229
40
41
10.17
34.98
1.1
1.0
5.41
14.00
u/ml
1.22
31
32
768
5844
3.26
34.94
8.5
8.1
73.84
77.47
u/l
1.43
753
5582
159
573
3.16
33.99
1.2
1.2
—
—
—
0
0
52
86
6.36
30.47
5.4
2.7
—
—
—
0
0
33
33
10.35
29.30
1.4
1.5
7.83
8.58
ug/l
0.52
33
33
38
12
33.00
29.27
2.1
4.5
—
—
—
0
0
65
138
5.00
29.18
3.5
3.7
4.78
4.24
e9/l
0.91
65
138
42
59
7.42
28.61
1.2
1.0
1.35
0.81
u/ml
—
25
10
117
389
3.31
28.36
1.5
2.0
3.76
6.90
iu/ml
1.13
19
83
71
181
4.18
25.36
3.5
3.5
57.93
56.72
%
0.31
71
181
36
18
20.78
24.48
1.4
1.0
5.02
0.61
u/ml
—
30
10
306
1800
2.07
21.75
3.9
4.2
—
—
—
0
0
879
7833
9.38
21.22
20.8
13.4
15.76
21.81
mg/l
8.92
801
6344
368
2337
1.98
20.91
7.4
6.0
—
—
—
0
0
541
3977
1.92
19.22
5.0
6.6
9.74
10.91
umol/l
2.31
516
3799
29
42
7.10
19.18
1.8
1.7
2752.00
3931.43
titre
—
5
7
304
1869
1.95
18.49
1.9
1.8
0.68
1.05
mg/l
2.86
240
1421
496
3578
1.87
18.32
3.0
2.5
75.98
75.05
nmol/l
0.33
473
3305
38
78
5.04
17.70
1.3
2.6
1673.34
1247.42
e6/l
1.61
29
69
286
1745
1.94
17.64
3.2
2.9
338.97
728.82
ng/l
7.66
239
1424
45
108
4.33
17.37
1.3
1.2
—
—
—
0
0
94
365
2.76
17.14
1.2
1.2
0.25
1.71
u/ml
—
6
18
394
2684
1.84
17.11
3.9
3.2
18.95
57.84
ng/l
0.92
243
1621
214
1202
2.03
16.62
2.6
3.5
0.82
0.82
mmol/l
0.02
202
1155
107
451
2.56
16.56
2.6
3.4
7.42
7.42
ph
0.95
90
374
439
3124
1.80
16.23
3.9
5.0
36.77
36.76
g/l
0.02
419
2966
196
1076
2.05
16.16
1.3
1.2
—
—
—
0
0
330
2161
1.84
16.03
1.5
1.3
1.24
1.62
u/ml
0.28
97
622
24
14
17.58
15.67
1.1
1.0
3.11
0.04
u/ml
—
16
7
163
844
2.14
15.66
1.3
1.5
—
—
—
0
0
144
710
2.23
15.64
1.4
1.2
81.72
145.74
u/ml
2.20
51
292
31
60
5.32
15.41
1.3
2.6
524.71
507.75
e6/l
0.07
21
48
328
2167
1.81
15.33
1.9
2.1
—
—
—
0
0
425
3043
1.76
14.99
9.1
9.4
1.11
1.13
inr
0.46
360
2493
654
5318
1.86
14.75
4.9
4.2
—
3.88
—
0
8
744
6317
2.07
14.70
5.2
4.4
14.76
14.52
pmol/l
2.22
710
5930
303
1978
1.81
14.59
2.6
2.6
334.29
331.63
umol/l
0.19
281
1803
355
2432
1.76
14.47
2.6
2.7
52.44
61.60
u/l
2.44
329
2276
21
12
17.89
13.88
1.1
1.0
0.14
3.12
u/ml
—
13
5
25
44
5.82
13.73
2.0
4.2
408.20
694.43
u/ml
1.54
25
44
468
3506
1.70
13.53
5.9
7.3
1.22
1.21
mmol/l
0.90
400
3061
545
4261
1.72
13.39
3.9
3.5
10.05
3.60
estimate
0.27
150
876
107
496
2.31
13.38
2.1
2.7
67.67
67.59
g/l
0.04
102
472
424
3108
1.69
13.17
2.0
2.0
—
—
—
0
0
29
61
4.88
13.14
1.4
2.7
221.00
215.35
e6/l
0.06
21
52
63
229
2.88
12.97
2.7
2.6
9.52
11.40
mg/l
2.03
63
215
424
3117
1.69
12.96
6.1
6.7
1.22
1.21
mmol/l
0.23
403
2920
539
4227
1.70
12.84
3.9
3.4
0.00
0.00
estimate
0.50
149
867
333
2309
1.71
12.57
3.5
3.1
—
0.83
—
0
6
384
2766
1.68
12.56
4.1
3.6
18.68
78.21
e6/l
2.76
281
1837
542
4289
1.67
12.18
3.9
3.5
0.02
0.01
estimate
0.18
148
815
89
398
2.37
12.07
2.2
2.3
—
—
—
0
0
258
1692
1.74
11.78
1.4
1.3
24.95
28.67
iu/ml
0.21
74
521
203
1242
1.82
11.75
1.4
1.6
—
—
—
0
0
103
496
2.22
11.74
2.7
3.3
77.91
73.72
e9/l
0.42
78
352
46
148
3.22
11.68
3.5
2.9
—
—
—
0
0
15
5
30.47
11.67
2.8
1.6
43.73
35.00
umol/l
—
15
5
244
1579
1.75
11.66
1.4
1.3
8.92
11.94
u/ml
0.33
95
660
547
4384
1.64
11.28
5.1
5.0
6.39
6.51
mmol/l
0.81
528
4109
277
1872
1.70
11.25
2.7
2.1
2.70
2.76
mg/l
0.20
258
1616
239
1558
1.73
11.05
2.7
2.6
7.52
6.72
e6/l
0.20
219
1413
25
54
4.73
11.00
1.1
1.1
1393.68
1497.37
miu/ml
0.19
25
54
410
3076
1.62
10.96
2.1
1.9
98.82
97.48
pmol/l
0.27
262
1638
599
4940
1.65
10.76
4.7
4.1
305.71
688.34
e6/l
—
7
62
892
8660
+∞
10.73
32.9
20.5
90.69
90.53
fl
0.55
892
8593
851
7834
2.88
10.72
19.2
14.7
3.89
3.94
mmol/l
7.47
843
7671
892
8662
+∞
10.53
32.8
20.4
30.19
30.24
pg
0.40
892
8594
892
8662
+∞
10.53
33.3
20.9
41.86
40.96
%
10.10
892
8588
44
147
3.10
10.51
1.3
1.2
—
—
—
0
0
74
324
2.40
10.51
2.7
3.6
—
—
—
0
0
323
2304
1.63
10.49
3.2
3.1
33.44
44.20
e6/l
0.24
252
1707
892
8666
+∞
10.34
33.3
20.6
139.10
137.30
g/l
4.12
892
8596
119
637
2.00
10.25
3.7
3.6
—
—
—
0
0
72
324
2.33
9.62
1.7
1.6
7.44
8.20
u/ml
0.13
15
87
121
667
1.94
9.57
3.0
3.2
1.81
1.82
%
0.01
115
610
306
2194
1.60
9.54
2.0
2.1
200.96
198.57
u/l
0.02
294
2100
314
2270
1.59
9.43
3.8
3.6
0.00
0.01
estimate
1.28
148
835
878
8290
4.77
9.38
15.4
11.2
28.60
27.55
u/l
0.57
873
8119
845
7822
2.52
9.22
19.0
14.6
139.84
139.68
mmol/l
1.39
836
7680
152
914
1.80
9.14
1.4
1.4
—
—
—
0
0
20
27
7.55
8.96
1.2
2.6
0.33
0.29
e9/l
0.12
11
14
37
123
3.10
8.94
4.4
3.6
2.56
2.46
mmol/l
0.08
26
81
437
3441
1.53
8.79
3.3
3.1
6.16
6.19
ph
0.22
264
2026
279
1991
1.58
8.72
2.9
2.9
0.21
0.35
e6/l
1.26
210
1408
506
4126
1.52
8.54
3.9
3.1
89.36
104.45
ug/l
1.09
484
3915
51
207
2.55
8.53
1.6
1.8
9.28
10.47
g/l
0.99
44
197
333
2490
1.54
8.40
2.0
3.3
2.34
2.36
mmol/l
1.19
314
2300
329
2457
1.54
8.33
3.1
2.9
0.00
0.02
estimate
1.74
134
719
188
1232
1.67
8.26
2.8
2.6
110.94
113.76
ug/g
0.06
152
992
804
7351
1.95
8.24
6.4
5.3
1.76
1.80
mu/l
0.57
779
6965
181
1178
1.67
8.15
2.2
2.5
13.75
14.09
umol/l
0.22
171
1103
199
1333
1.63
8.00
2.6
2.7
553.59
536.81
mosm/kgh2o
0.44
177
1168
285
2085
1.54
7.83
3.6
4.1
7.40
7.40
ph
0.70
209
1475
14
13
10.92
7.81
1.4
1.6
—
—
—
0
0
15
16
9.51
7.80
1.1
1.0
0.96
1.20
u/ml
—
10
6
96
530
1.91
7.53
3.0
3.7
1.23
1.23
mmol/l
0.01
87
465
24
68
3.60
7.46
1.6
3.9
—
—
—
0
0
168
1099
1.65
7.37
2.2
2.4
2.53
2.39
g/l
2.67
157
1016
670
5897
1.55
7.20
3.7
3.3
41.30
45.27
u/l
0.84
647
5653
23
65
3.61
7.18
1.1
1.1
101.74
112.86
pmol/l
0.85
23
65
84
457
1.93
6.89
1.1
1.1
—
201.60
—
0
10
407
3268
1.45
6.83
3.6
3.3
0.00
0.02
estimate
2.19
132
733
13
15
8.78
6.56
1.1
1.2
—
—
—
0
0
247
1810
1.50
6.55
1.6
1.7
—
—
—
0
0
120
740
1.72
6.54
1.2
1.2
—
—
—
0
0
37
148
2.56
6.43
1.2
1.2
—
—
—
0
0
260
1936
1.48
6.34
1.7
1.6
19.42
20.59
nmol/l
0.80
230
1671
150
994
1.61
6.19
2.2
2.5
22.96
23.69
%
0.25
138
935
22
67
3.34
6.17
1.2
1.2
—
—
—
0
0
861
8198
2.45
5.96
15.9
11.8
—
—
—
0
0
82
472
1.81
5.66
1.3
1.2
—
—
—
0
0
36
153
2.41
5.54
2.0
2.2
139.56
133.13
g/l
0.86
27
124
782
7266
1.62
5.29
6.4
5.6
38.29
38.31
mmol/mol
0.02
756
6933
28
109
2.62
5.17
1.1
1.3
—
52.11
—
0
7
355
2887
1.38
5.09
3.1
3.4
32.23
31.70
u/l
0.07
340
2744
795
7436
1.64
5.00
4.3
4.0
1.30
1.30
mmol/l
0.09
758
7017
22
77
2.90
4.95
3.2
2.8
32.14
33.18
pg
0.65
22
77
51
263
2.00
4.93
2.8
3.8
191.00
340.95
mg/l
0.96
13
119
28
113
2.53
4.83
1.7
1.7
—
—
—
0
0
28
113
2.53
4.83
1.8
1.7
—
—
—
0
0
28
113
2.53
4.83
1.7
1.7
—
—
—
0
0
28
113
2.53
4.83
1.8
1.7
—
—
—
0
0
828
7839
1.78
4.83
5.2
4.7
4.85
4.75
mmol/l
2.29
795
7460
89
550
1.69
4.82
1.1
1.1
—
—
—
0
0
138
951
1.53
4.78
1.7
1.6
1142.84
1173.43
nmol/l
0.13
113
740
40
192
2.13
4.68
2.1
3.1
1.45
2.50
index
0.69
20
103
110
728
1.58
4.55
6.7
9.4
1.30
0.76
mmol/l
0.98
89
611
109
721
1.58
4.52
2.2
2.1
0.00
0.03
estimate
0.78
22
166
824
7813
1.72
4.47
5.0
4.7
1.51
1.46
mmol/l
2.20
791
7409
187
1392
1.43
4.39
1.8
1.6
42073596.04
35449731.60
pmol/l
0.05
164
1213
110
736
1.56
4.34
6.6
9.3
4.99
5.13
kpa
0.85
103
714
110
736
1.56
4.34
6.6
9.3
11.76
12.61
kpa
1.19
104
716
95
614
1.61
4.34
3.4
4.1
7.39
7.35
ph
2.25
79
450
38
185
2.10
4.31
1.1
1.1
7.37
16.25
au/ml
—
10
62
830
7896
1.74
4.30
5.5
5.2
2.88
2.83
mmol/l
1.11
797
7498
178
1319
1.44
4.28
3.6
3.5
92.85
593.19
ng/l
2.93
112
882
32
146
2.24
4.25
1.8
3.0
6.15
7.90
pmol/l
0.70
32
146
109
734
1.55
4.19
6.8
9.4
7.44
7.42
ph
1.81
56
394
23
91
2.57
4.16
1.2
1.1
30.96
14.99
u/ml
—
9
44
45
239
1.93
4.04
1.7
2.0
0.94
2.13
ug/l
0.50
37
221
99
659
1.56
4.00
6.8
9.9
96.66
96.07
%
1.02
93
644
175
1309
1.42
3.98
1.9
2.6
2.43
2.43
mmol/l
0.13
160
1182
48
264
1.86
3.89
1.2
1.1
—
—
—
0
0
84
542
1.61
3.88
3.3
3.7
4.57
4.68
pmol/l
0.56
75
485
79
505
1.62
3.79
1.8
2.2
7146.65
5862.78
u/l
0.13
23
223
32
156
2.09
3.65
2.1
2.1
3.71
5.21
umol/l
0.88
21
115
64
394
1.67
3.56
2.2
2.2
0.00
1.79
estimate
0.50
18
140
62
380
1.68
3.51
7.5
8.4
24.92
24.57
mmol/l
0.38
57
366
250
2021
1.33
3.47
2.8
2.6
—
—
—
0
0
93
632
1.53
3.45
7.2
10.1
132.41
122.74
g/l
5.42
88
622
13
43
3.05
3.26
1.4
1.6
1.36
1.44
nmol/l
—
7
31
391
3386
1.28
3.17
2.1
1.9
1.38
1.41
mmol/l
0.21
326
2955
783
7433
1.44
3.15
5.1
4.5
5.61
5.82
mmol/l
7.81
747
6981
418
3655
1.27
3.12
3.0
2.9
—
—
—
0
0
122
894
1.42
3.11
2.0
2.9
4.43
6.77
umol/l
3.03
104
786
19
80
2.40
3.07
1.1
1.4
—
—
—
0
0
8
16
5.03
3.05
1.0
1.1
0.10
0.02
u/ml
—
8
16
46
272
1.73
3.00
1.1
1.2
60.00
103.24
titre
—
6
34
42
242
1.77
2.99
1.3
1.3
—
—
—
0
0
23
108
2.16
2.92
1.3
1.3
0.47
0.55
nmol/l
0.95
23
100
9
22
4.12
2.88
1.7
2.1
43.60
42.60
g/l
—
9
22
16
64
2.53
2.88
1.0
1.1
—
—
—
0
0
20
90
2.25
2.81
1.4
1.6
150.30
23.25
ng/l
0.46
20
90
45
270
1.70
2.80
1.2
1.2
—
1135.00
titre
—
0
8
24
118
2.06
2.73
1.8
1.7
—
—
—
0
0
55
353
1.59
2.66
2.5
1.9
38.46
38.94
nmol/l
0.05
55
343
17
75
2.29
2.52
4.1
2.3
1.30
0.95
%
0.51
12
42
297
2548
1.25
2.47
3.7
3.4
8.32
8.19
mmol/l
0.17
262
2210
266
2259
1.25
2.41
4.3
4.2
4.71
10.12
mg/mmol
2.31
170
1407
6
12
5.03
2.40
1.5
2.5
—
—
—
0
0
415
3704
1.23
2.36
2.4
2.7
—
—
estimate
—
0
0
83
598
1.43
2.35
2.4
2.4
7.75
18.74
au/ml
—
8
65
27
147
1.86
2.35
1.2
1.1
—
—
—
0
0
10
34
2.96
2.28
1.0
1.1
—
—
—
0
0
10
34
2.96
2.28
1.0
1.1
—
—
—
0
0
10
34
2.96
2.28
1.0
1.1
—
—
—
0
0
19
92
2.09
2.28
1.0
2.2
—
—
—
0
0
40
250
1.63
2.19
3.8
7.1
0.92
0.88
%
0.23
34
234
259
2215
1.24
2.18
3.7
3.6
29.28
54.54
mg/l
1.76
162
1417
27
154
1.78
2.06
1.1
1.1
1.41
2.12
eliau/ml
—
9
69
16
76
2.13
2.03
2.4
2.2
—
—
—
0
0
6
16
3.77
1.93
1.0
1.0
10.73
6.02
mg/g
—
6
16
18
92
1.98
1.91
1.2
1.2
—
—
nmol/l
—
0
0
60
425
1.44
1.90
2.6
1.9
—
—
—
0
0
57
400
1.45
1.90
1.1
1.1
—
—
—
0
0
8
28
2.87
1.86
1.0
1.3
—
—
—
0
0
42
278
1.54
1.85
3.9
6.6
1.67
1.64
%
0.07
36
262
30
184
1.65
1.80
3.2
3.5
22.29
31.52
mg/l
1.85
23
154
30
184
1.65
1.80
3.3
3.5
21.59
69.44
mg/l
0.84
23
155
56
396
1.44
1.80
3.4
2.8
82.76
115.92
ng/l
0.47
49
356
8
29
2.77
1.79
1.1
2.2
22.00
30.07
%
—
8
29
13
60
2.18
1.78
1.2
1.1
—
—
—
0
0
98
763
1.32
1.77
3.2
2.4
13.34
13.46
nmol/l
0.05
91
715
15
74
2.04
1.75
1.1
1.2
—
—
—
0
0
16
81
1.99
1.75
1.1
1.2
—
—
—
0
0
18
96
1.89
1.71
1.3
1.2
0.16
0.17
nmol/l
0.43
12
69
15
75
2.02
1.70
1.1
1.1
—
—
—
0
0
27
165
1.66
1.66
3.0
3.3
0.98
1.53
ratio
1.94
13
92
12
56
2.16
1.61
1.1
1.3
—
—
—
0
0
67
500
1.37
1.61
2.3
2.0
—
—
—
0
0
72
544
1.35
1.60
2.4
2.0
—
—
—
0
0
77
588
1.34
1.60
7.2
9.3
—
—
—
0
0
72
545
1.35
1.59
2.2
1.9
—
—
—
0
0
10
43
2.34
1.59
1.2
1.3
145.20
154.88
nmol/l
—
10
43
48
340
1.44
1.56
2.8
1.8
—
—
—
0
0
72
548
1.34
1.54
2.3
1.9
—
—
—
0
0
136
1126
1.25
1.53
2.9
2.7
3.38
2.78
e6/l
0.35
56
503
34
226
1.52
1.51
1.1
1.2
—
—
—
0
0
9
37
2.45
1.48
2.8
2.0
60.69
63.68
ug/l
—
9
37
80
623
1.31
1.47
2.3
2.0
6.19
6.13
ph
0.20
42
395
17
291
0.58
1.46
1.5
1.5
1.08
1.26
mm
1.33
11
207
21
125
1.70
1.44
5.2
11.1
10.50
11.35
mmol/l
1.03
16
116
21
125
1.70
1.44
5.2
11.1
103.88
105.38
mmol/l
0.70
16
116
6
22
2.74
1.43
1.0
1.9
—
—
—
0
0
25
385
0.64
1.41
1.6
1.5
46.05
62.91
ug/l
1.66
19
323
36
248
1.47
1.37
1.3
2.0
1.72
1.47
g/l
0.70
28
220
35
240
1.48
1.36
1.5
1.5
330.50
290.92
ug/g
0.47
20
146
112
923
1.24
1.33
7.3
7.7
104.73
104.37
mmol/l
0.40
112
923
5
18
2.79
1.28
1.0
1.0
—
—
—
0
0
6
134
0.44
1.28
2.3
2.6
—
27.19
—
0
11
12
62
1.95
1.28
1.7
2.2
7.80
33.74
mg/l
—
5
46
11
55
2.01
1.27
1.4
1.3
163.89
172.87
pmol/l
0.10
11
55
50
372
1.36
1.27
1.3
1.2
—
—
—
0
0
152
1302
1.20
1.25
1.8
1.8
—
—
—
0
0
8
37
2.17
1.21
1.3
1.2
132.88
182.59
mmol/24h
—
8
37
19
299
0.63
1.21
1.5
1.5
—
—
—
0
0
30
206
1.47
1.19
1.9
2.2
—
—
—
0
0
6
26
2.32
1.19
1.3
1.3
24.67
27.46
s
—
6
26
32
225
1.44
1.13
1.2
1.1
—
—
—
0
0
32
225
1.44
1.13
1.2
1.1
—
—
—
0
0
20
305
0.65
1.12
1.5
1.5
—
—
—
0
0
16
96
1.68
1.10
1.3
1.1
—
—
—
0
0
18
112
1.62
1.09
2.2
2.3
—
—
—
0
0
275
2504
1.14
1.05
2.1
2.3
—
—
—
0
0
6
125
0.48
1.05
1.2
1.3
—
—
—
0
0
68
546
1.27
1.04
2.4
1.9
—
—
—
0
0
73
592
1.25
1.03
1.2
1.3
25.01
25.24
iu/l
0.02
66
512
32
230
1.41
1.03
3.2
2.5
—
—
—
0
0
54
423
1.29
1.01
1.4
1.3
171.49
236.27
miu/ml
0.59
18
213
7
36
1.95
0.97
1.6
4.0
7.80
8.70
mmol/l
—
7
36
26
182
1.44
0.97
1.3
1.6
7446.68
11414.51
e6/l
0.39
19
136
23
157
1.48
0.97
1.2
1.2
6.13
5.34
u/ml
0.09
15
67
140
1222
1.17
0.95
2.8
2.6
0.64
0.96
e6/l
0.97
62
600
150
1317
1.17
0.95
1.6
1.5
—
—
—
0
0
0
32
0.00
0.95
0.0
1.2
—
—
—
0
0
6
27
2.23
0.93
2.3
1.4
—
—
—
0
0
116
1000
1.18
0.92
1.3
1.2
—
—
—
0
0
10
170
0.58
0.90
1.1
1.5
3.38
2.78
ug/l
—
10
154
132
1153
1.17
0.90
3.1
2.7
0.55
0.67
ug/l
2.29
71
628
34
254
1.35
0.89
2.4
2.0
3.22
4.11
iu/l
0.31
13
105
23
160
1.45
0.89
1.1
1.1
—
—
—
0
0
6
30
2.01
0.87
1.7
4.5
17.55
17.00
%
—
6
30
53
656
0.80
0.86
1.5
1.6
880.61
998.22
mu/l
0.52
45
550
10
167
0.59
0.85
1.7
1.6
—
—
—
0
0
80
675
1.20
0.82
3.7
4.1
7.40
7.38
ph
1.38
29
390
24
173
1.40
0.79
1.0
1.1
—
—
—
0
0
14
90
1.56
0.78
1.0
1.1
—
—
—
0
0
0
28
0.00
0.76
0.0
1.2
—
—
—
0
0
5
24
2.09
0.74
1.0
1.0
49.18
36.48
iu/ml
—
5
24
9
55
1.64
0.73
1.0
1.2
8.78
8.56
mm/h
—
9
55
207
1895
1.12
0.73
2.0
2.2
—
—
—
0
0
49
598
0.81
0.73
1.8
1.7
—
—
—
0
0
29
221
1.32
0.70
1.1
1.2
203.94
244.81
u/ml
0.61
16
131
118
1045
1.15
0.70
1.6
1.8
—
—
—
0
0
12
77
1.57
0.68
1.8
6.0
11.64
11.17
%
0.15
12
77
201
1844
1.12
0.68
4.8
4.3
1.51
1.92
ug/l
1.11
186
1700
15
215
0.69
0.68
1.1
1.3
—
—
—
0
0
75
644
1.18
0.66
3.4
4.0
1.63
1.82
mmol/l
0.14
70
557
10
62
1.62
0.65
1.0
1.1
—
—
—
0
0
10
62
1.62
0.65
1.0
1.6
—
—
—
0
0
34
269
1.27
0.64
1.9
4.0
1.19
1.37
mg/l
1.27
34
250
38
305
1.26
0.64
2.1
1.7
—
—
—
0
0
47
387
1.23
0.64
1.9
2.6
—
—
—
0
0
60
507
1.20
0.64
3.0
4.0
76.76
80.03
ng/l
0.11
52
458
85
745
1.16
0.60
2.5
2.6
47.67
107.32
u/l
0.44
69
633
28
219
1.29
0.59
1.0
1.1
—
—
—
0
0
26
202
1.30
0.58
1.2
1.5
2.60
9.24
e6/l
1.11
20
152
8
54
1.49
0.57
1.4
2.7
—
—
—
0
0
18
132
1.37
0.57
1.3
1.3
—
—
—
0
0
9
60
1.51
0.54
1.1
1.4
87.78
74.40
umol/l
—
9
60
14
99
1.42
0.54
2.5
2.2
—
—
—
0
0
6
39
1.54
0.53
1.5
1.2
105.00
589.97
u/l
—
6
34
6
39
1.54
0.53
1.7
1.4
—
—
—
0
0
6
40
1.50
0.51
1.7
1.7
—
—
—
0
0
201
1876
1.09
0.50
3.6
3.4
1.02
1.02
kg/l
0.02
138
1228
54
625
0.86
0.50
3.2
4.5
2.71
13.57
ug/l
0.92
43
504
33
271
1.23
0.49
1.4
1.2
—
—
—
0
0
7
45
1.56
0.49
1.0
1.1
153.70
155.66
iu/ml
—
7
45
7
46
1.53
0.48
2.3
4.6
1.00
0.85
index
—
7
46
42
358
1.18
0.44
1.5
1.4
12.00
9.01
u/l
0.47
35
293
69
612
1.14
0.44
1.4
1.4
—
—
—
0
0
18
139
1.30
0.44
5.7
3.6
19.27
23.81
mg/l
0.41
11
92
5
32
1.57
0.42
1.4
1.9
57.20
125.47
ng/l
—
5
32
38
442
0.85
0.39
1.4
2.7
20.31
64.91
u/ml
1.02
38
428
5
35
1.43
0.39
3.0
1.6
—
—
—
0
0
5
35
1.43
0.39
2.6
1.2
0.00
0.09
estimate
—
5
35
5
36
1.39
0.38
1.0
1.3
—
—
—
0
0
9
68
1.33
0.37
2.7
2.6
—
—
—
0
0
6
45
1.34
0.33
1.5
1.4
—
—
—
0
0
7
56
1.25
0.29
1.6
1.2
—
—
—
0
0
18
148
1.22
0.29
1.1
1.1
40.00
59.19
iu/ml
—
5
35
7
57
1.23
0.29
1.1
1.1
1.08
1.05
ratio
—
7
49
52
470
1.11
0.28
1.3
1.7
0.28
0.33
mg/l
0.27
22
226
5
72
0.69
0.26
2.6
2.4
109.20
105.28
mmol/l
—
5
72
5
72
0.69
0.26
2.6
2.4
3.90
4.01
mmol/l
—
5
72
5
72
0.69
0.26
2.6
2.4
1.20
1.19
mmol/l
—
5
72
24
208
1.16
0.24
1.2
1.4
—
—
—
0
0
103
1091
0.94
0.23
1.3
1.3
—
—
—
0
0
5
40
1.25
0.22
1.8
2.0
—
74.12
—
0
6
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
1.61
—
0
13
6
48
1.25
0.20
3.0
1.6
0.63
0.48
e9/l
—
6
48
21
239
0.88
0.19
14.2
8.0
—
—
—
0
0
41
447
0.91
0.19
1.1
1.1
1.51
1.52
g/l
0.08
41
447
6
52
1.15
0.19
1.7
1.4
36.02
34.00
g/l
—
6
47
95
907
1.05
0.16
1.7
1.7
3.75
3.51
mmol/l
1.31
64
652
34
313
1.09
0.15
2.6
2.2
—
—
—
0
0
43
458
0.94
0.13
1.1
1.2
0.89
0.90
g/l
0.10
43
458
11
94
1.17
0.13
1.0
1.8
—
—
—
0
0
16
143
1.12
0.11
1.1
1.2
—
—
—
0
0
16
177
0.90
0.10
2.2
1.8
—
—
—
0
0
11
96
1.15
0.10
1.2
1.7
—
—
—
0
0
5
47
1.06
0.09
1.0
1.4
—
86.00
%
—
0
8
21
194
1.08
0.09
1.2
1.4
172.33
162.62
au/ml
—
6
57
7
66
1.06
0.08
1.1
1.1
—
—
—
0
0
20
187
1.07
0.06
1.1
1.6
—
—
—
0
0
255
2578
0.98
0.06
1.6
1.6
—
—
—
0
0
15
162
0.92
0.06
1.7
2.4
7.60
154.38
ug/min
—
9
92
15
141
1.06
0.03
3.9
3.6
—
—
—
0
0
21
201
1.05
0.03
1.8
1.4
0.48
0.34
nmol/l
0.24
11
165
10
97
1.03
0.00
1.1
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
8.23
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.7
—
7.06
—
0
9
0
8
0.00
-0.00
0.0
1.1
—
15.88
—
0
8
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.93
-0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
401.67
—
0
6
120
1200
1.00
-0.00
2.1
1.9
3.69
3.51
ratio
0.80
86
939
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
57.46
—
0
7
0
6
0.00
-0.00
0.0
2.3
—
360.17
—
0
6
0
6
0.00
-0.00
0.0
1.5
—
520.20
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
325.43
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint RX_ASTMA_BIOL and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have RX_ASTMA_BIOL.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: RX_ASTMA_BIOL – Biological medicines for asthma

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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