Alopecia areata

L12_ALOPECAREATA

alopecia areata: Loss of scalp and body hair involving microscopically inflammatory patchy areas.

Suggest a new description

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L63
  • Hospital discharge: ICD-9 7040B|7040C
  • Hospital discharge: ICD-8 70400
  • Cause of death: ICD-10 L63
  • Cause of death: ICD-9 7040B|7040C
  • Cause of death: ICD-8 70400

2 out of 7 registries used, show all original rules.

1178

4. Check minimum number of events

None

1178

5. Include endpoints

None

1178

6. Filter based on genotype QC (FinnGen only)

1076

Control definitions (FinnGen only)

Control exclude
L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L60-L75
Name in latin
Alopecia areata

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7560 5187 2341
Only index persons 7028 4903 2125
Unadjusted period prevalence (%)
Whole population 0.12 0.15 0.07
Only index persons 0.15 0.18 0.08
Median age at first event (years)
Whole population 32.57 36.09 24.73
Only index persons 33.86 37.07 26.45

-FinnGen-

Key figures

All Female Male
Number of individuals 1076 855 221
Unadjusted period prevalence (%) 0.26 0.30 0.10
Median age at first event (years) 44.98 45.04 44.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1125
Matched controls
11250
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L63.8
ICD-10 Finland
Other alopecia areata
2700.2
307.7
472
*
L63.9
ICD-10 Finland
Alopecia areata, unspecified
961.8
307.7
570
12
L63.0
ICD-10 Finland
Alopecia (capitis) totalis
+∞
196.8
183
*
S23
ICPC
Hair loss/baldness
37.2
195.5
123
37
D07AD01
ATC
clobetasol; topical
5.8
170.4
433
1096
L63
ICD-10 Finland
Alopecia areata
203.9
155.1
158
9
D07AC01
ATC
betamethasone; topical
4.6
137.7
679
2818
L63.1
ICD-10 Finland
Alopecia universalis
1403.5
130.9
125
*
D07AC13
ATC
mometasone; topical
4.0
113.8
550
2178
L65.9
ICD-10 Finland
Nonscarring hair loss, unspecified
32.7
81.7
53
17
D07AB02
ATC
hydrocortisone butyrate; topical
2.5
47.5
452
2363
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.9
44.9
145
411
70400
ICD-8 Finland
Diseases of hair and hair follicles, Alopecia areata (benigna, maligna)
+∞
43.0
41
*
L64.9
ICD-10 Finland
Androgenic alopecia, unspecified
95.9
42.1
46
5
E0000UV, ,
ATC
2.3
42.1
589
3601
TQW80
NOMESCO Finland
Local dermatologic skincare
7.3
41.4
62
89
XQ802
NOMESCO Finland
Epicutan test
4.6
40.9
103
242
D07AA02
ATC
hydrocortisone; topical
2.6
36.5
248
1085
H02AB06
ATC
prednisolone; systemic
2.2
34.7
588
3786
L20.0
ICD-10 Finland
Besnier prurigo
2.8
30.0
164
637
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.7
27.7
165
669
D07AB08
ATC
desonide; topical
2.6
26.3
168
705
XQ845
NOMESCO Finland
Dermatoscopy
7.2
25.6
38
54
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.6
23.5
155
659
L04AD01
ATC
ciclosporin; systemic
6.0
23.2
41
70
D07XC01
ATC
betamethasone; topical
2.5
22.8
153
655
L04AA01
ATC
[U] ciclosporin
8.3
22.7
30
37
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.0
22.1
290
1639
E000001, ,
ATC
2.0
20.7
266
1489
E000002, ,
ATC
2.3
19.6
163
767
XQ848
NOMESCO Finland
Dermatological photography
4.7
18.8
44
97
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.0
18.8
263
1511
L64.8
ICD-10 Finland
Other androgenic alopecia
182.8
17.6
18
*
D02AE01
ATC
carbamide; topical
2.7
17.2
93
357
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.1
16.8
174
894
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
4.4
16.0
40
93
C03DA01
ATC
spironolactone; oral
2.4
15.8
120
542
D11AH01
ATC
tacrolimus; topical
6.0
15.8
28
48
XQ800
NOMESCO Finland
Prick test
2.3
14.6
112
507
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
5.0
14.1
30
61
L65.8
ICD-10 Finland
Other specified nonscarring hair loss
30.4
13.9
18
6
D06BX01
ATC
metronidazole; topical
2.1
13.6
131
651
L04AX03
ATC
methotrexate; systemic
2.2
13.6
124
603
R06AX22
ATC
ebastine; oral
1.8
13.5
227
1370
D11AH02
ATC
pimecrolimus; topical
13.0
13.4
23
18
H04.10
ICD-10 Finland
Dry eye syndrome
2.0
13.3
159
857
E000003, ,
ATC
2.8
13.1
65
238
R06AE07
ATC
cetirizine; oral
1.6
13.1
539
4113
L04AX01
ATC
azathioprine; systemic
3.0
12.7
58
203
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
12.7
455
3352
H03AA01
ATC
levothyroxine sodium; systemic
1.7
12.6
284
1860
70401
ICD-8 Finland
Diseases of hair and hair follicles, Alopecia alia sive NUD
+∞
12.5
12
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.9
12.3
172
976
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
5.4
11.9
23
43
L71.8
ICD-10 Finland
Other rosacea
9.4
11.5
23
25
E000006, ,
ATC
2.3
11.5
87
392
7040B
ICD-9 Finland
Diseases of hair and hair follicles, Alopecia[ALOPECIA AREATA]
+∞
11.5
11
*
L70.0
ICD-10 Finland
Acne vulgaris
3.5
11.3
38
110
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
11.2
447
3349
D02AX
ATC
Other emollients and protectives
3.0
11.1
48
163
D11AX14
ATC
[U] tacrolimus
10.2
11.0
21
21
D05AX52
ATC
calcipotriol, combinations; topical
2.6
11.0
62
243
J05AB01
ATC
aciclovir; systemic
1.7
10.8
261
1733
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
2.6
10.7
64
259
R06AX27
ATC
desloratadine; oral
1.6
10.6
382
2792
L66.9
ICD-10 Finland
Cicatricial alopecia, unspecified
111.0
10.4
11
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.0
10.3
124
669
L71.9
ICD-10 Finland
Rosacea, unspecified
3.8
10.2
31
84
H02AB04
ATC
methylprednisolone; systemic
1.8
10.0
152
885
L04AA06
ATC
mycophenolic acid; systemic
4.0
9.6
27
69
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
4.4
9.6
24
56
D11AX15
ATC
[U] pimecrolimus
15.2
9.5
15
10
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
2.7
9.5
52
201
H01.0
ICD-10 Finland
Blepharitis
2.0
9.5
99
507
P01BA02
ATC
hydroxychloroquine; oral
2.1
9.4
97
494
L65.2
ICD-10 Finland
Alopecia mucinosa
+∞
9.4
9
*
J01AA04
ATC
lymecycline; systemic
1.8
9.0
153
919
UJF32
NOMESCO Finland
Coloscopy
1.6
9.0
241
1634
127
Kela drug reimbursment
Transplant complication
4.4
8.9
22
51
L30.8
ICD-10 Finland
Other specified dermatitis
3.0
8.8
39
135
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.7
8.7
195
1263
E000007, ,
ATC
2.2
8.7
71
331
D07AC14
ATC
methylprednisolone aceponate; topical
2.4
8.7
59
254
D07AB01
ATC
clobetasone; topical
2.8
8.6
43
159
S24
ICPC
Hair/scalp symptom/complaint other
4.1
8.3
22
54
A07AA02
ATC
nystatin; oral
2.3
8.2
64
292
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
8.2
208
1390
R03AC02
ATC
salbutamol; inhalant
1.4
8.0
630
5289
WZC00, ,
SPAT
1.7
7.8
172
1109
104
Kela drug reimbursment
Thyroid insufficiency
2.1
7.8
78
394
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
7.7
203
1368
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.7
7.6
143
885
J02AC02
ATC
itraconazole; systemic
1.6
7.6
186
1232
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
7.6
318
2369
K50.1
ICD-10 Finland
Crohn disease of large intestine
4.3
7.5
19
45
L66.1
ICD-10 Finland
Lichen planopilaris
80.6
7.4
8
*
134
Kela drug reimbursment
General erythroderma
13.5
7.4
12
9
N05BB01
ATC
hydroxyzine; systemic
2.0
7.4
76
388
WZA10
NOMESCO Finland
Extensive medical or dental certificate
3.8
7.4
22
59
L80
ICD-10 Finland
Vitiligo
6.9
7.3
17
25
L01BA01
ATC
methotrexate; systemic
2.7
7.3
39
150
R5110, ,
SPAT
1.9
7.2
87
470
R01AD09
ATC
mometasone; nasal
1.4
7.2
529
4356
A02BC02
ATC
pantoprazole; systemic
1.4
7.2
689
5938
J01DA01
ATC
[U] cefalexin
1.4
7.1
646
5511
L73.8
ICD-10 Finland
Other specified follicular disorders
8.8
7.1
14
16
L93.0
ICD-10 Finland
Discoid lupus erythematosus
10.1
7.0
13
13
L21.9
ICD-10 Finland
Seborrhoeic dermatitis, unspecified
3.4
7.0
24
71
M13.9
ICD-10 Finland
Arthritis, unspecified
1.9
6.9
82
440
L43.8
ICD-10 Finland
Other lichen planus
3.6
6.9
22
62
J01AA02
ATC
doxycycline; systemic
1.4
6.8
797
7081
L71.0
ICD-10 Finland
Perioral dermatitis
3.2
6.7
26
83
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
2.7
6.6
35
134
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.9
6.6
85
470
SPAT1229
SPAT
Assessment of need for aid
2.1
6.6
62
307
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.0
6.5
74
391
L30.3
ICD-10 Finland
Infective dermatitis
2.5
6.5
40
165
A07EC01
ATC
sulfasalazine; oral, rectal
1.9
6.5
83
458
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
1.9
6.4
73
388
A01AB09
ATC
miconazole; local oral
1.8
6.3
87
491
S01GX01
ATC
cromoglicic acid; ophthalmic
1.5
6.3
247
1807
L63.2
ICD-10 Finland
Ophiasis
+∞
6.3
6
*
L20
ICD-10 Finland
Atopic dermatitis
2.2
6.2
48
219
L26
ICD-10 Finland
Exfoliative dermatitis
26.8
6.2
8
*
D07BC01
ATC
betamethasone and antiseptics; topical
1.7
6.2
111
676
J05AB11
ATC
valaciclovir; oral
1.6
6.2
161
1078
N03AX16
ATC
[U] pregabalin
1.5
6.2
211
1501
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
3.8
6.1
18
48
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
4.1
6.1
16
39
R50.9
ICD-10 Finland
Fever, unspecified
1.6
6.0
158
1060
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.4
6.0
266
1990

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
76
67
12.09
73.97
1.1
1.5
22.49
25.78
umol/l
0.28
68
61
333
1569
2.59
42.82
1.5
1.4
437.30
549.44
titre
0.64
74
322
114
363
3.38
29.34
1.2
1.2
—
—
—
0
0
460
2840
2.05
28.78
1.6
1.4
2.12
1.88
u/ml
0.09
139
752
127
453
3.03
27.01
2.3
1.9
6.30
6.91
iu/ml
0.10
32
95
122
434
3.03
26.04
1.3
1.2
1.20
1.25
u/ml
—
8
33
199
959
2.31
22.86
1.2
1.2
137.14
143.61
u/ml
0.10
82
377
96
322
3.17
22.61
1.4
1.2
2.00
2.83
u/ml
—
8
28
95
323
3.12
21.86
1.5
1.3
3.07
8.71
u/ml
0.74
15
46
99
345
3.05
21.84
1.4
1.2
3.53
29.32
u/ml
—
7
16
706
5340
1.86
21.73
9.6
6.7
0.21
0.18
e9/l
4.07
651
4693
687
5160
1.85
21.54
9.5
6.5
0.04
0.04
e9/l
1.60
627
4471
686
5153
1.85
21.47
9.5
6.4
0.55
0.55
e9/l
0.44
626
4469
695
5287
1.82
20.38
9.6
6.5
1.96
1.98
e9/l
0.20
643
4699
480
3280
1.81
20.10
8.6
6.7
—
—
—
0
0
630
4756
1.74
17.95
9.4
6.7
8.62
8.45
%
0.89
602
4483
378
2470
1.80
17.90
1.9
1.5
2.17
2.24
g/l
0.44
256
1555
628
4745
1.73
17.76
9.3
6.6
3.24
2.79
%
4.61
600
4464
696
5416
1.75
17.66
3.5
3.2
91.37
90.13
ug/l
0.08
657
5110
955
8221
2.07
17.07
6.2
4.7
14.92
14.54
pmol/l
5.26
904
7678
624
4740
1.71
17.00
9.4
6.7
0.74
0.69
%
1.91
595
4447
640
4902
1.71
16.84
9.4
6.5
29.14
29.24
%
0.08
619
4676
628
4830
1.68
15.87
9.0
6.4
55.83
56.42
%
0.67
612
4626
159
811
2.12
15.55
5.5
4.7
0.48
0.66
%
0.61
50
225
722
5786
1.69
15.38
11.4
9.4
3.92
3.98
e9/l
0.38
658
5063
160
828
2.09
15.04
1.7
1.3
564.25
222.89
u/ml
1.58
154
781
375
2545
1.71
15.01
2.5
2.2
2.52
2.71
mg/l
1.17
339
2195
161
839
2.07
14.85
5.9
5.1
0.00
0.59
%
0.81
45
193
163
854
2.06
14.82
5.9
4.7
0.77
1.01
%
0.61
50
243
47
133
3.64
14.45
1.3
1.3
—
—
—
0
0
88
360
2.57
14.31
2.4
1.7
1.18
1.21
g/l
0.41
83
340
602
4655
1.63
14.27
3.0
2.5
77.84
75.89
nmol/l
1.04
552
4295
591
4553
1.63
14.19
8.3
7.2
1.21
1.22
mmol/l
0.36
501
3953
155
820
2.03
13.68
6.0
4.8
0.14
0.09
%
0.32
44
208
360
2475
1.67
13.44
7.7
4.4
—
—
—
0
0
184
1049
1.90
13.05
2.2
2.1
358.78
380.04
nmol/l
0.84
171
983
70
271
2.69
12.72
1.4
1.2
9.70
45.57
u/ml
—
7
28
174
1006
1.86
11.75
1.3
1.2
—
—
—
0
0
516
3970
1.55
11.61
5.8
4.9
36.45
36.48
g/l
0.04
492
3753
50
170
3.03
11.53
4.5
3.7
4.25
4.19
e9/l
0.06
50
170
439
3282
1.55
11.08
3.2
3.3
2.35
2.36
mmol/l
1.12
399
3021
1024
9376
2.03
10.57
7.4
5.6
1.83
1.83
mu/l
0.02
980
8855
234
1526
1.67
10.33
2.6
2.4
13.61
14.06
umol/l
0.44
223
1425
512
4011
1.51
10.14
2.1
2.0
96.80
97.36
pmol/l
0.10
269
2089
517
4062
1.50
10.07
7.7
6.6
1.22
1.22
mmol/l
0.04
477
3761
179
1125
1.70
8.99
1.8
1.6
—
—
—
0
0
139
816
1.80
8.85
4.7
3.0
10.39
10.44
g/l
0.05
133
757
265
1848
1.57
8.75
1.6
1.7
447.89
41841701.14
pmol/l
2.45
223
1575
196
1272
1.65
8.71
2.9
3.1
4.46
5.29
e9/l
0.82
169
1128
121
690
1.84
8.47
2.3
2.4
0.53
0.42
e6/l
0.17
112
650
210
1397
1.62
8.44
2.5
2.4
2.44
2.39
g/l
0.59
199
1299
385
2933
1.48
8.31
5.6
3.7
0.01
0.01
estimate
0.03
165
1055
54
232
2.39
7.98
4.6
3.4
56.63
58.16
%
0.31
54
232
30
94
3.25
7.98
2.5
3.0
1155.96
1260.05
e6/l
0.28
23
82
192
1268
1.62
7.91
2.6
2.5
22.56
23.47
%
0.46
181
1189
15
16
9.48
7.79
1.1
1.1
—
—
u/ml
—
0
0
247
1745
1.53
7.58
2.8
2.6
2.43
2.44
mmol/l
0.36
219
1574
392
3049
1.44
7.40
3.7
2.5
55.03
61.15
u/l
1.50
371
2831
333
2513
1.46
7.38
1.7
1.6
20.11
20.95
nmol/l
0.48
285
2168
14
16
8.84
7.06
1.2
1.2
—
—
—
0
0
820
7310
1.45
6.93
10.4
7.6
78.72
77.45
u/l
0.37
799
6948
24
72
3.38
6.85
2.5
3.3
223.81
204.65
e6/l
0.22
16
62
133
830
1.68
6.81
2.9
3.6
7.36
7.36
ph
0.11
90
599
350
2717
1.42
6.51
2.6
2.1
142.35
189.35
u/l
0.97
333
2588
295
2221
1.44
6.49
5.1
4.2
—
—
—
0
0
107
640
1.74
6.39
2.7
1.9
1.21
1.34
g/l
0.30
102
598
539
4510
1.37
6.37
15.6
10.6
0.00
0.00
e9/l
1.20
468
3701
21
61
3.49
6.30
2.1
3.6
962.10
775.20
u/ml
0.29
21
61
270
2013
1.45
6.23
3.5
2.5
7.18
7.84
e6/l
0.25
251
1831
29
104
2.84
6.19
1.4
1.4
0.46
0.36
g/l
0.60
24
78
29
104
2.84
6.19
1.4
1.4
3.08
2.86
g/l
0.26
24
77
29
104
2.84
6.19
1.4
1.4
7.53
6.08
g/l
0.73
24
79
34
133
2.60
6.16
3.1
3.2
0.86
1.35
%
0.54
29
121
284
2143
1.44
6.13
1.4
1.3
19.67
29.02
iu/ml
1.84
84
635
215
1542
1.49
6.03
3.3
2.5
112.90
110.46
ug/g
0.06
175
1232
83
469
1.83
6.01
2.3
2.1
0.00
0.02
estimate
0.68
34
161
22
69
3.23
5.89
2.4
3.4
513.23
494.09
e6/l
0.07
13
56
639
5534
1.36
5.88
5.6
5.1
6.66
6.45
mmol/l
1.09
599
5147
112
697
1.67
5.80
5.1
3.3
1.23
1.23
mmol/l
0.60
99
596
174
1208
1.52
5.70
1.7
1.4
—
—
—
0
0
634
5506
1.35
5.61
4.9
3.7
0.02
0.29
estimate
0.48
170
1057
458
3792
1.35
5.55
10.5
10.3
1.12
1.14
inr
0.65
387
3124
629
5468
1.34
5.46
5.0
3.6
7.46
2.63
estimate
0.28
174
1110
101
624
1.68
5.39
4.7
3.0
—
—
—
0
0
338
2679
1.37
5.38
6.1
3.7
7.40
7.40
ph
0.31
248
1900
38
168
2.31
5.35
5.0
2.4
8.89
7.79
pmol/l
0.36
38
168
185
1325
1.47
5.19
1.6
1.7
1184.88
1200.78
nmol/l
0.07
144
1005
27
103
2.66
5.17
1.5
1.4
—
—
—
0
0
109
695
1.63
5.15
3.4
4.2
75.77
75.23
ng/l
0.03
94
619
238
1791
1.42
5.13
1.7
1.8
—
—
—
0
0
231
1740
1.41
4.94
3.6
2.7
520.77
520.34
mosm/kgh2o
0.01
206
1534
204
1505
1.43
4.89
4.3
3.9
0.83
0.82
mmol/l
0.20
196
1431
35
157
2.27
4.79
1.4
1.6
—
—
—
0
0
15
42
3.61
4.77
1.5
4.4
45.67
135.52
umol/l
—
6
27
136
931
1.52
4.75
2.2
2.0
0.00
0.02
estimate
0.78
37
201
256
1981
1.38
4.64
1.4
1.3
18.02
9.66
u/ml
0.80
108
781
174
1263
1.45
4.54
2.2
2.0
—
—
—
0
0
615
5416
1.30
4.47
5.0
3.6
0.00
0.00
estimate
0.50
167
1100
58
323
1.84
4.46
1.1
1.1
12.58
7.10
eliau/ml
—
6
51
101
660
1.58
4.34
1.2
1.3
107.57
35.55
au/ml
—
6
53
393
3273
1.31
4.30
3.7
3.3
43.88
43.76
ng/l
0.00
257
2000
15
39
3.88
4.20
2.7
4.0
0.15
0.24
e9/l
—
7
22
30
134
2.27
4.18
1.3
1.6
25.57
25.54
ng/l
0.00
30
134
949
8926
1.40
4.11
6.3
5.5
38.44
38.20
mmol/mol
0.35
898
8469
1064
10246
1.71
4.09
16.3
11.8
—
—
—
0
0
8
10
8.05
4.06
1.4
1.0
—
—
—
0
0
153
1108
1.44
4.04
1.5
1.4
—
—
—
0
0
361
2998
1.30
3.98
3.8
3.1
27.40
75.82
e6/l
1.20
294
2244
98
650
1.56
3.96
3.4
2.6
66.41
66.86
g/l
0.21
90
606
277
2221
1.33
3.93
3.0
3.1
1189.72
825.81
ng/l
0.57
235
1848
69
421
1.68
3.91
5.7
7.3
—
—
—
0
0
563
4953
1.27
3.91
7.5
6.2
10.40
10.79
umol/l
0.35
543
4709
974
9220
1.42
3.91
5.1
4.5
5.73
5.76
mmol/l
0.30
905
8614
57
330
1.77
3.89
1.4
1.2
—
—
—
0
0
43
230
1.90
3.78
1.4
1.6
—
—
—
0
0
290
2353
1.31
3.76
1.9
2.0
1.07
1.04
mg/l
0.07
221
1791
29
134
2.19
3.76
1.2
1.1
—
—
—
0
0
105
719
1.51
3.69
2.3
2.4
22.84
20.69
au/ml
—
10
80
1025
9817
1.50
3.65
18.9
13.4
19.21
21.38
mg/l
1.45
858
7906
171
1291
1.38
3.57
2.4
2.7
28.73
29.35
s
0.99
166
1256
476
4143
1.26
3.49
5.2
3.4
0.22
0.03
estimate
0.54
141
915
107
747
1.48
3.43
3.4
3.4
4.48
4.59
pmol/l
0.69
102
662
284
2325
1.30
3.42
3.1
2.6
324.11
319.17
umol/l
0.37
251
2083
719
6572
1.26
3.40
5.5
4.3
35.67
2508.10
e6/l
—
6
83
81
534
1.56
3.40
3.2
2.2
—
—
—
0
0
9
18
5.03
3.37
2.2
1.4
9.58
9.07
mmol/l
—
9
18
23
102
2.28
3.30
1.3
1.2
—
—
—
0
0
20
84
2.41
3.24
3.7
3.2
54.70
55.68
%
0.08
15
74
355
3007
1.26
3.23
3.5
2.7
—
—
—
0
0
34
178
1.94
3.22
1.9
1.7
0.52
0.76
g/l
1.04
28
145
497
4383
1.24
3.14
4.4
3.3
6.30
6.24
ph
0.72
295
2488
188
1471
1.33
3.12
1.6
1.6
—
—
—
0
0
49
292
1.71
3.08
1.4
1.2
95.00
93.16
titre
—
6
38
417
3621
1.24
3.01
4.5
3.8
61.14
86.39
e6/l
0.53
310
2416
50
302
1.69
3.00
1.4
1.2
—
1330.91
—
0
11
5
5
10.04
2.98
1.0
1.2
—
—
—
0
0
31
162
1.94
2.97
5.5
2.9
1.73
2.48
mmol/l
1.06
18
104
95
668
1.46
2.96
3.4
3.4
69.57
72.57
e9/l
0.31
78
482
22
101
2.20
2.94
1.4
1.3
5.72
2.34
u/ml
0.26
11
49
40
228
1.78
2.94
1.2
1.8
—
—
—
0
0
8
17
4.73
2.92
1.0
1.1
—
—
—
0
0
307
2589
1.26
2.85
3.7
3.0
0.22
0.39
e6/l
1.15
241
1852
151
1159
1.35
2.85
7.4
6.1
1.07
1.06
mmol/l
0.27
146
1073
21
96
2.21
2.84
1.2
1.2
—
—
—
0
0
106
769
1.42
2.81
9.3
10.7
95.12
95.58
%
0.18
100
753
1014
9762
1.39
2.80
19.2
14.9
139.58
139.66
mmol/l
0.54
1001
9578
1008
9696
1.38
2.78
5.8
5.2
2.80
2.80
mmol/l
0.01
946
9172
46
279
1.68
2.74
3.1
3.2
24.03
24.80
mmol/l
0.85
46
274
114
842
1.39
2.73
6.5
3.6
—
—
—
0
0
21
98
2.16
2.72
1.5
1.7
63.50
56.16
%
0.40
16
64
22
105
2.12
2.70
3.0
2.6
1.12
0.91
%
0.48
17
65
118
879
1.38
2.69
8.8
9.9
5.23
5.12
kpa
0.67
112
852
118
879
1.38
2.69
8.7
9.9
11.91
12.66
kpa
1.03
112
853
1061
10313
1.51
2.62
15.1
11.0
24.69
25.17
u/l
0.61
1042
10063
399
3491
1.22
2.60
4.0
3.3
31.29
29.67
u/l
0.27
382
3313
116
868
1.38
2.58
8.8
10.0
0.98
0.97
mmol/l
0.01
103
726
31
171
1.84
2.56
6.1
3.0
—
—
—
0
0
351
3035
1.23
2.56
7.2
6.0
—
—
—
0
0
358
3102
1.23
2.56
3.7
3.4
7.43
7.65
mmol/l
0.40
305
2690
10
31
3.25
2.52
1.1
1.0
—
—
—
0
0
10
31
3.25
2.52
1.1
1.0
—
—
—
0
0
10
31
3.25
2.52
1.1
1.0
—
—
—
0
0
997
9600
1.34
2.50
5.4
4.6
4.74
4.75
mmol/l
0.14
940
9112
119
899
1.36
2.50
3.1
3.3
1.61
1.83
%
1.47
109
816
283
2397
1.24
2.50
4.9
3.6
1.02
1.65
kg/l
0.50
190
1584
1013
9778
1.36
2.50
19.3
15.0
3.94
3.93
mmol/l
0.63
999
9569
11
37
2.99
2.49
2.2
1.6
29.55
29.32
%
0.02
11
37
15
63
2.40
2.47
1.0
1.1
1836.47
1505.25
miu/ml
0.37
15
63
116
878
1.36
2.42
9.1
10.0
7.41
7.42
ph
0.38
69
477
1100
10799
1.84
2.41
27.9
20.6
268.50
260.17
e9/l
4.52
1095
10623
19
90
2.13
2.39
1.6
1.5
0.67
1.16
promille
0.82
13
73
1100
10804
1.82
2.33
27.8
20.6
4.50
4.50
e12/l
0.02
1093
10605
1100
10806
1.81
2.30
27.8
20.6
6.73
6.73
e9/l
0.02
1093
10600
316
2731
1.22
2.28
5.0
4.1
8.61
15.04
mg/mmol
0.45
190
1678
317
2747
1.21
2.22
2.1
2.1
—
—
—
0
0
35
210
1.69
2.22
1.5
1.6
133.13
141.10
au/ml
—
8
64
271
2318
1.22
2.16
1.8
1.7
—
—
—
0
0
10
36
2.79
2.14
2.4
1.9
58.36
79.57
ug/l
—
10
36
944
9066
1.26
2.11
4.6
3.9
1.21
1.25
mmol/l
1.31
890
8492
351
3085
1.20
2.11
4.3
3.0
0.01
0.04
estimate
0.50
148
903
61
424
1.46
2.09
2.4
2.2
—
—
—
0
0
114
886
1.32
2.02
3.6
5.0
7.38
7.38
ph
0.18
77
500
21
111
1.91
2.01
1.2
2.0
—
—
—
0
0
753
7091
1.19
1.98
3.8
3.3
39.93
41.11
u/l
0.19
720
6762
140
1124
1.28
1.95
8.5
7.8
104.28
104.33
mmol/l
0.05
140
1124
5
11
4.56
1.94
2.6
2.1
59.54
84.44
ng/l
—
5
5
1059
10349
1.40
1.90
22.3
16.3
71.75
70.39
umol/l
1.10
1051
10239
37
236
1.59
1.89
4.4
3.2
47.46
59.30
mg/l
0.16
31
201
37
236
1.59
1.89
4.4
3.2
25.12
49.13
mg/l
0.98
31
199
38
244
1.58
1.89
2.0
2.7
4.10
7.12
umol/l
1.52
25
185
168
1385
1.25
1.89
1.3
1.2
—
—
—
0
0
287
2501
1.20
1.87
3.6
2.9
—
0.00
estimate
—
0
7
30
182
1.67
1.86
1.3
1.2
190.21
192.21
iu/ml
—
9
38
0
54
0.00
1.85
0.0
1.0
—
—
—
0
0
52
360
1.47
1.84
2.5
2.2
4.44
18.60
iu/l
0.48
21
160
41
270
1.54
1.84
3.4
5.9
8.90
8.56
kpa
0.69
41
263
65
470
1.41
1.83
1.1
1.1
—
—
—
0
0
62
445
1.42
1.82
1.3
1.3
—
—
—
0
0
7
23
3.06
1.80
3.3
2.8
29.64
52.85
%
—
7
23
78
585
1.36
1.78
3.4
4.7
7.42
7.42
ph
0.17
61
490
61
440
1.41
1.75
1.5
1.6
3.01
10.82
u/ml
—
8
101
305
2689
1.18
1.74
4.0
3.4
49.44
46.35
mg/l
0.10
184
1691
987
9571
1.25
1.73
5.2
4.6
1.52
1.51
mmol/l
0.28
930
9032
109
863
1.29
1.72
3.5
4.9
1.80
1.77
mmol/l
0.03
98
748
46
317
1.47
1.69
1.9
2.1
1.55
1.47
g/l
0.23
41
281
7
25
2.81
1.65
1.9
1.6
—
—
—
0
0
15
76
1.99
1.64
1.3
1.6
—
—
—
0
0
33
213
1.57
1.64
4.2
3.1
3.09
1.84
ratio
0.31
23
113
29
448
0.64
1.61
1.5
1.6
—
—
—
0
0
40
578
0.68
1.61
1.5
1.5
64.12
61.03
ug/l
0.19
34
494
134
1102
1.25
1.56
2.9
3.2
5.38
6.56
umol/l
0.93
111
952
30
192
1.58
1.55
4.6
4.0
—
—
—
0
0
14
72
1.96
1.49
1.1
1.2
—
—
—
0
0
36
243
1.50
1.48
1.3
1.4
290.65
218.46
u/ml
0.73
20
143
9
37
2.44
1.48
1.8
1.7
—
—
—
0
0
36
245
1.48
1.44
1.2
1.7
12.96
7.07
e6/l
0.25
23
176
358
3241
1.15
1.43
2.5
2.3
—
—
—
0
0
31
205
1.53
1.41
1.6
1.6
12513.52
14791.25
e6/l
0.15
23
156
46
331
1.41
1.39
1.1
1.1
2.59
3.11
u/ml
0.12
31
178
20
119
1.69
1.38
2.6
2.2
—
—
—
0
0
16
89
1.81
1.37
1.1
1.1
—
—
—
0
0
29
430
0.67
1.37
1.5
1.5
1.22
1.28
mm
0.36
23
315
17
97
1.76
1.35
3.7
2.6
—
—
—
0
0
36
249
1.46
1.34
1.2
1.7
54.33
178.29
e6/l
1.26
27
187
105
1273
0.81
1.31
1.3
1.2
—
—
—
0
0
10
48
2.09
1.28
1.9
1.7
75.66
95.33
ng/l
—
10
48
15
84
1.80
1.27
1.0
1.1
139.20
109.86
pmol/l
2.06
15
84
9
44
2.05
1.27
1.3
1.2
337.44
530.21
u/l
—
9
39
73
575
1.29
1.25
2.3
2.2
6.92
8.04
ug/l
0.29
63
513
8
37
2.17
1.21
1.3
1.3
—
—
—
0
0
20
124
1.62
1.21
1.2
1.3
—
—
nmol/l
—
0
0
15
86
1.75
1.19
3.2
3.8
—
—
—
0
0
14
79
1.78
1.17
1.1
1.1
302.64
294.96
mg/l
0.15
14
74
31
438
0.70
1.17
1.5
1.5
—
—
—
0
0
24
158
1.53
1.15
1.2
1.2
—
—
—
0
0
52
397
1.32
1.13
2.2
3.4
19.92
20.99
s
1.25
36
356
446
4151
1.12
1.13
2.0
1.9
1.36
1.34
mmol/l
0.16
373
3603
8
40
2.01
1.12
1.3
1.3
—
—
—
0
0
22
143
1.55
1.12
1.3
1.3
0.59
0.59
nmol/l
0.01
22
135
115
969
1.21
1.11
1.3
1.5
—
—
—
0
0
55
425
1.31
1.10
2.2
1.9
—
—
—
0
0
69
550
1.27
1.10
2.3
2.1
12.51
12.01
nmol/l
0.13
64
510
28
193
1.46
1.10
1.1
1.1
3.78
2.51
eliau/ml
0.25
11
91
17
104
1.64
1.09
4.5
2.4
—
—
—
0
0
84
1017
0.81
1.06
1.5
1.6
1114.93
998.07
mu/l
0.62
75
866
431
4022
1.12
1.03
2.1
2.0
—
—
—
0
0
50
386
1.31
1.03
1.6
1.5
16.20
9.11
u/l
1.45
39
316
23
334
0.68
1.03
1.3
1.3
—
—
—
0
0
144
1250
1.17
1.01
4.9
4.6
7.47
2.04
ug/l
0.54
131
1129
96
806
1.21
0.98
2.8
4.4
4.07
15.30
ug/l
1.31
73
643
38
284
1.35
0.97
1.1
1.1
2.49
2.06
u/ml
0.13
24
150
504
4756
1.11
0.96
3.1
2.8
—
—
estimate
—
0
0
33
242
1.37
0.95
1.1
1.1
12.14
5.71
u/ml
0.60
19
126
6
27
2.23
0.93
1.3
2.0
25.32
99.93
u/l
—
6
27
6
27
2.23
0.93
1.5
1.1
—
—
—
0
0
120
1382
0.85
0.91
1.9
1.9
3.53
3.40
ratio
0.55
90
1057
40
307
1.31
0.88
6.1
7.3
1.23
1.32
mg/l
0.52
40
279
6
30
2.01
0.87
1.5
1.1
—
—
—
0
0
38
291
1.32
0.85
1.4
1.4
307.81
297.06
ug/g
0.11
17
170
6
31
1.94
0.84
1.2
1.3
9.38
2.65
u/ml
—
6
31
6
31
1.94
0.84
1.2
1.1
0.46
26.22
u/ml
—
6
21
6
31
1.94
0.84
1.0
1.0
—
—
—
0
0
43
336
1.29
0.84
3.2
4.4
161.75
372.80
mg/l
2.19
16
139
26
188
1.39
0.83
1.2
1.2
—
—
—
0
0
8
46
1.74
0.82
1.6
1.7
—
4533.33
—
0
6
11
65
1.70
0.82
1.7
2.1
1.67
2.57
u/field
—
6
42
20
138
1.46
0.82
1.9
1.6
—
—
—
0
0
20
138
1.46
0.82
1.9
1.6
—
—
—
0
0
20
138
1.46
0.82
1.9
1.6
—
—
—
0
0
20
138
1.46
0.82
1.9
1.6
—
—
—
0
0
6
32
1.88
0.82
5.8
3.1
—
—
—
0
0
24
172
1.40
0.81
4.0
2.4
230.55
102.62
ug/min
0.35
18
108
87
740
1.19
0.81
2.7
2.9
0.60
0.74
ug/l
1.63
50
422
266
2450
1.11
0.80
2.4
2.3
—
—
—
0
0
446
4217
1.10
0.79
3.2
2.8
—
—
—
0
0
12
74
1.63
0.78
6.3
1.7
—
—
—
0
0
13
197
0.66
0.75
3.0
4.4
14.18
25.34
u/ml
1.41
13
192
91
1053
0.85
0.75
1.7
1.7
3.61
3.45
mmol/l
0.66
65
737
33
254
1.31
0.74
1.7
1.7
47.73
42.60
nmol/l
0.47
33
245
17
117
1.46
0.72
1.7
1.9
—
—
—
0
0
7
40
1.75
0.71
1.4
3.1
11.37
8.49
mmol/l
—
7
40
54
449
1.21
0.66
2.0
2.6
—
—
—
0
0
5
28
1.79
0.66
2.4
2.4
—
—
—
0
0
20
145
1.39
0.66
1.4
1.4
—
—
—
0
0
29
224
1.30
0.65
1.1
1.1
12.56
7.13
u/ml
0.55
17
104
37
296
1.26
0.64
1.1
1.1
10.35
4.70
u/ml
0.72
25
171
84
730
1.16
0.64
2.6
2.3
3749.05
5833.56
u/l
0.41
24
324
5
29
1.73
0.64
1.0
1.9
36.12
42.23
g/l
—
5
29
25
190
1.32
0.63
2.0
1.3
4.73
3.95
u/ml
0.12
11
77
75
649
1.17
0.61
1.6
1.9
—
—
—
0
0
106
1190
0.88
0.61
1.4
1.3
—
—
—
0
0
14
97
1.45
0.59
1.0
1.2
—
—
—
0
0
59
502
1.19
0.59
1.3
1.3
208.75
248.67
miu/ml
0.49
31
251
8
54
1.48
0.57
1.3
1.2
—
—
—
0
0
75
654
1.16
0.56
1.6
1.9
—
—
—
0
0
74
645
1.16
0.56
1.6
2.0
—
—
—
0
0
35
284
1.24
0.56
1.1
1.1
0.70
1.36
u/ml
0.64
19
128
6
37
1.62
0.55
1.2
1.4
66.68
78.08
nmol/24h
—
6
37
15
107
1.41
0.55
5.5
2.8
—
—
—
0
0
6
38
1.58
0.54
4.3
1.2
0.00
0.00
estimate
—
6
38
14
99
1.42
0.54
1.0
1.2
31.95
29.96
mg/l
—
8
77
83
733
1.14
0.53
1.3
1.2
—
—
—
0
0
86
764
1.14
0.51
8.2
9.9
—
—
—
0
0
36
299
1.21
0.48
1.9
2.3
—
—
—
0
0
13
93
1.40
0.48
1.2
1.1
—
—
—
0
0
26
208
1.26
0.48
1.0
1.1
0.13
0.27
u/ml
0.42
13
66
12
85
1.42
0.47
1.0
1.1
9.76
3.67
u/ml
—
6
37
24
191
1.26
0.46
1.1
1.1
—
—
—
0
0
24
192
1.26
0.45
1.0
1.1
—
—
—
0
0
29
238
1.22
0.44
2.9
2.8
4.86
2.05
index
0.34
14
115
867
8530
1.07
0.43
21.3
16.6
13.45
13.44
%
0.15
859
8422
6
94
0.64
0.42
2.0
1.6
—
—
—
0
0
8
57
1.41
0.42
1.1
1.3
—
—
—
0
0
72
643
1.13
0.42
1.6
1.8
—
—
—
0
0
5
33
1.52
0.41
2.6
3.4
15.32
16.40
%
—
5
33
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
8
59
1.36
0.41
1.1
1.2
14.25
8.39
mm/h
—
8
59
38
325
1.18
0.39
1.0
1.2
—
—
—
0
0
5
35
1.43
0.39
3.4
2.3
12.98
17.60
umol/l
—
5
35
5
35
1.43
0.39
1.6
1.4
—
—
—
0
0
64
571
1.13
0.38
3.3
5.2
24.10
24.16
mmol/l
0.06
64
565
35
298
1.18
0.38
1.2
1.2
—
—
—
0
0
65
581
1.13
0.38
1.4
1.2
—
—
—
0
0
6
42
1.43
0.35
3.0
2.1
—
21.42
—
0
6
250
2386
1.06
0.35
4.5
4.2
94.80
94.38
%
0.10
241
2336
10
73
1.37
0.34
3.3
2.7
—
—
—
0
0
6
87
0.69
0.33
1.7
1.1
—
—
—
0
0
6
46
1.31
0.33
4.7
3.6
—
—
—
0
0
6
46
1.31
0.33
3.7
3.1
0.67
0.83
index
—
6
46
87
800
1.09
0.32
1.4
1.4
20.34
25.07
iu/l
0.85
74
677
6
47
1.28
0.32
1.2
1.6
128.67
158.29
mmol/24h
—
6
47
53
476
1.12
0.30
10.9
11.1
24.50
24.31
mmol/l
0.15
53
467
170
1611
1.07
0.30
2.7
2.8
0.64
1.09
e6/l
3.66
101
815
10
75
1.34
0.30
1.5
1.3
72.50
72.79
umol/l
—
10
75
57
515
1.11
0.30
1.7
1.9
—
—
—
0
0
35
306
1.15
0.30
1.3
1.3
—
—
—
0
0
170
1616
1.06
0.28
1.5
1.6
—
—
—
0
0
34
299
1.14
0.27
1.9
3.1
17.38
893.66
u/ml
1.18
29
260
13
104
1.25
0.26
2.3
2.7
27.31
23.74
nmol/l
0.29
13
98
11
86
1.28
0.26
1.1
1.0
—
—
—
0
0
9
72
1.25
0.25
1.6
1.1
—
—
—
0
0
155
1476
1.06
0.25
2.7
3.0
4.48
4.02
e6/l
0.15
86
686
43
476
0.90
0.25
1.1
1.1
1.56
1.56
g/l
0.01
43
476
173
1655
1.05
0.24
4.2
3.4
945.75
452.42
ng/l
0.44
120
1097
66
612
1.08
0.23
1.7
2.0
—
—
—
0
0
78
834
0.93
0.22
2.4
2.2
6.10
6.15
ph
0.21
47
545
50
545
0.91
0.22
1.0
1.1
—
—
—
0
0
5
40
1.25
0.22
2.2
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
5.1
—
0.18
—
0
11
25
220
1.14
0.21
2.3
2.4
—
—
—
0
0
0
12
0.00
0.21
0.0
8.1
—
—
—
0
0
29
259
1.12
0.20
1.4
1.5
0.41
0.42
nmol/l
0.06
23
216
0
14
0.00
0.20
0.0
1.2
—
1.81
—
0
14
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
6
48
1.25
0.20
1.3
1.3
96.17
170.85
pmol/l
—
6
48
6
48
1.25
0.20
1.0
1.1
169.13
181.55
iu/ml
—
6
48
11
90
1.22
0.19
1.0
1.1
2.69
1.02
u/ml
—
5
31
32
290
1.11
0.18
9.5
8.1
—
—
—
0
0
322
3293
0.97
0.17
1.7
1.7
—
—
—
0
0
8
68
1.18
0.16
1.0
1.2
—
—
—
0
0
8
69
1.16
0.16
1.1
1.2
—
—
—
0
0
15
130
1.16
0.15
4.3
2.3
—
—
—
0
0
10
119
0.84
0.15
1.0
2.3
—
—
—
0
0
71
674
1.06
0.15
2.5
2.9
87.39
69.10
u/ml
0.10
71
654
11
93
1.18
0.14
1.2
1.2
—
—
—
0
0
41
384
1.07
0.13
1.3
1.3
—
—
—
0
0
130
1341
0.97
0.12
1.9
1.8
—
—
—
0
0
46
487
0.94
0.12
1.2
1.2
0.87
0.88
g/l
0.14
46
487
11
95
1.16
0.11
1.3
1.1
—
—
—
0
0
5
46
1.09
0.09
1.4
1.4
115.20
151.70
nmol/l
—
5
46
74
714
1.04
0.09
2.4
1.7
—
—
—
0
0
22
237
0.93
0.09
4.1
4.9
58.87
62.16
%
0.27
22
228
6
56
1.07
0.08
1.2
1.6
—
—
—
0
0
45
430
1.05
0.08
3.0
5.0
—
—
—
0
0
5
64
0.78
0.08
1.6
1.6
0.48
0.48
e9/l
—
5
64
7
64
1.09
0.08
1.9
2.1
—
—
—
0
0
6
72
0.83
0.07
1.0
1.1
—
—
—
0
0
43
449
0.96
0.07
1.1
1.1
0.69
0.62
ratio
—
6
52
95
926
1.03
0.07
2.8
2.4
34.91
90.62
u/l
0.53
87
769
18
194
0.93
0.07
1.2
1.1
—
—
—
0
0
28
265
1.06
0.07
1.0
1.1
—
—
—
0
0
28
265
1.06
0.07
1.0
1.1
—
—
—
0
0
20
187
1.07
0.06
1.4
1.2
—
—
—
0
0
55
565
0.97
0.05
1.7
1.6
290.32
295.62
mu/l
0.05
50
503
25
240
1.04
0.03
1.0
1.1
—
—
—
0
0
11
102
1.08
0.03
1.3
1.2
20.32
14.21
u/ml
—
5
45
81
798
1.02
0.03
1.6
1.4
—
—
—
0
0
32
311
1.03
0.02
1.2
1.5
99.37
200.46
pmol/l
0.94
32
304
53
521
1.02
0.02
2.3
1.8
—
—
—
0
0
48
487
0.98
0.01
1.4
1.6
0.27
0.32
mg/l
0.27
20
215
12
124
0.97
0.00
1.3
1.1
—
—
—
0
0
26
259
1.00
0.00
1.7
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
3.7
—
4.57
—
0
6
0
5
0.00
0.00
0.0
1.0
—
3.74
—
0
5
0
6
0.00
0.00
0.0
1.7
—
328.17
—
0
6
0
5
0.00
0.00
0.0
1.2
—
0.14
—
0
5
0
5
0.00
0.00
0.0
2.2
—
0.52
—
0
5
5
51
0.98
-0.00
2.2
1.8
1.00
1.90
u/field
—
5
41
9
92
0.98
-0.00
1.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
467.44
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
30.00
—
0
7

Mortality – FinRegistry

Association

Association between endpoint L12_ALOPECAREATA and mortality.

Females

Parameter HR [95% CI] p-value
L12_ALOPECAREATA 1.002 [0.85, 1.18] 0.981
Birth year 0.996 [0.99, 1.0] 0.338

During the follow-up period (1.1.1998 — 31.12.2019), 192 out of 4322 females with L12_ALOPECAREATA died.

Males

Parameter HR [95% CI] p-value
L12_ALOPECAREATA 0.868 [0.7, 1.08] 0.206
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 1847 males with L12_ALOPECAREATA died.

Mortality risk

Mortality risk for people of age

years, who have L12_ALOPECAREATA.

N-year risk Females Males
1 0.093% 0.179%
5 0.573% 1.007%
10 1.445% 2.59%
15 2.937% 4.999%
20 5.217% 8.461%

Relationships between endpoints

Index endpoint: L12_ALOPECAREATA – Alopecia areata

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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