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Urticaria due to cold and heat

DOID EFO Endpoint Browser PheWeb

L12_URTICA_COLDHEAT

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L50.2
  • Hospital discharge: ICD-9 — 7082
  • Cause of death: ICD-10 — L50.2
  • Cause of death: ICD-9 — 7082

2 out of 7 registries used, show all original rules.

350

4. Check minimum number of events

None

350

5. Include endpoints

None

350

6. Filter based on genotype QC (FinnGen only)

314

Control definitions (FinnGen only)

Control exclude
L12_URTICARIAERYTHEMA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L50
Name in latin
Urticaria ex calore

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2310 1500 804
Only index persons 2168 1431 737
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.02
Only index persons 0.04 0.05 0.03
Median age at first event (years)
Whole population 28.24 32.69 19.84
Only index persons 29.01 33.50 20.28

-FinnGen-

Key figures

All Female Male
Number of individuals 314 242 72
Unadjusted period prevalence (%) 0.07 0.09 0.03
Median age at first event (years) 38.79 39.86 35.19

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
330
Matched controls
3300
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L50.2
ICD-10 Finland
Urticaria due to cold and heat
16384.0
307.7
316
*
L50.9
ICD-10 Finland
Urticaria, unspecified
21.4
87.6
70
41
C01CA24
ATC
epinephrine; parenteral
10.8
71.6
90
111
XQ800
NOMESCO Finland
Prick test
10.8
71.6
90
111
L50.3
ICD-10 Finland
Dermatographic urticaria
152.8
70.1
72
6
R06AE09
ATC
levocetirizine; oral
6.9
64.0
138
310
L50.8
ICD-10 Finland
Other urticaria
133.1
44.0
46
*
R06AX27
ATC
desloratadine; oral
4.8
43.6
198
790
R03DC03
ATC
montelukast; oral
4.4
34.7
118
368
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
5.4
32.6
76
174
R06AX22
ATC
ebastine; oral
4.3
32.4
115
368
XQ810
NOMESCO Finland
Physical test for urticaria
+∞
29.6
28
*
R06AE07
ATC
cetirizine; oral
3.8
29.6
222
1157
H02AB06
ATC
prednisolone; systemic
3.5
27.0
203
1039
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
8.6
24.7
33
42
L50.0
ICD-10 Finland
Allergic urticaria
20.2
22.2
33
18
L50.5
ICD-10 Finland
Cholinergic urticaria
+∞
22.1
21
*
T78.4
ICD-10 Finland
Allergy, unspecified
5.8
19.7
38
72
R06AX13
ATC
loratadine; oral
3.2
18.3
89
338
H02AB07
ATC
prednisone; oral
3.5
16.3
65
217
7082A
ICD-9 Finland
Urticaria due to cold and heat[URTICARIA E FRIGORE]
+∞
14.7
14
*
L50.1
ICD-10 Finland
Idiopathic urticaria
28.7
14.4
19
7
D07AC13
ATC
mometasone; topical
2.6
14.3
119
593
XQ802
NOMESCO Finland
Epicutan test
5.1
13.8
30
63
D07AA02
ATC
hydrocortisone; topical
2.8
13.5
83
354
E000003, ,
ATC
4.6
13.0
32
75
R06AX26
ATC
fexofenadine; oral
3.5
12.8
49
158
E0000UV, ,
ATC
2.3
12.3
174
1079
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
3.5
12.3
46
146
E000002, ,
ATC
3.0
11.9
58
217
L20.0
ICD-10 Finland
Besnier prurigo
3.1
11.9
54
194
Z71.8
ICD-10 Finland
Other specified counselling
2.2
11.4
153
921
E000001, ,
ATC
2.5
11.1
91
443
J45.9
ICD-10 Finland
Asthma, unspecified
2.5
11.1
85
401
R03AC02
ATC
salbutamol; inhalant
2.3
11.0
220
1545
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
4.2
11.0
30
76
A02BC02
ATC
pantoprazole; systemic
2.3
10.9
234
1690
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
10.6
155
959
344
Kela drug reimbursment
Omalizumab
113.5
10.5
11
*
R01AD09
ATC
mometasone; nasal
2.1
10.2
187
1256
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
10.2
91
459
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.4
10.0
82
398
R20.2
ICD-10 Finland
Paraesthesia of skin
3.2
9.6
40
136
J01AA02
ATC
doxycycline; systemic
2.3
9.1
256
1985
R01AD12
ATC
fluticasone furoate; nasal
2.0
8.7
140
880
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.2
8.7
89
472
R01AD58
ATC
fluticasone, combinations; nasal
2.1
8.7
116
682
M79.1
ICD-10 Finland
Myalgia
2.3
8.6
74
364
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.7
8.5
50
206
N06AA12
ATC
doxepin; systemic
3.8
8.5
26
72
R03DX05
ATC
omalizumab; parenteral
92.3
8.5
9
*
A02BA02
ATC
ranitidine; systemic
2.5
8.3
60
273
D07AB08
ATC
desonide; topical
2.6
8.3
52
221
D07AB02
ATC
hydrocortisone butyrate; topical
2.0
8.3
114
676
D02AX
ATC
Other emollients and protectives
4.7
8.2
19
42
L50
ICD-10 Finland
Urticaria
7.1
8.2
19
28
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
2.0
8.2
122
744
U07
ICPC
Urine symptom/complaint other
3.1
8.1
36
127
X49
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified chemicals and noxious substances
22.7
8.1
11
5
R06AX18
ATC
acrivastine; oral
6.4
8.0
20
33
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
13.5
7.9
13
10
J02AC01
ATC
fluconazole; systemic
1.9
7.9
159
1072
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.1
7.7
34
119
M54.5
ICD-10 Finland
Low back pain
1.9
7.5
140
917
R42
ICD-10 Finland
Dizziness and giddiness
2.2
7.4
77
408
S01GX01
ATC
cromoglicic acid; ophthalmic
2.0
7.4
93
531
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
7.4
141
929
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.5
7.2
47
204
T78.3
ICD-10 Finland
Angioneurotic oedema
12.4
7.1
12
10
R03AK07
ATC
formoterol and budesonide; inhalant
2.0
6.9
87
496
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.1
6.8
76
414
A02BC05
ATC
esomeprazole; systemic
1.9
6.7
134
889
M79.6
ICD-10 Finland
Pain in limb
1.8
6.6
159
1114
K07.60
ICD-10 Finland
Snapping jaw
2.8
6.5
33
125
Z3231
NOMESCO Finland
Registered nurse
1.9
6.5
96
575
R03BA02
ATC
budesonide; inhalant
2.1
6.5
76
419
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
2.2
6.4
56
276
B07.9
ICD-10 Finland
Verruca simplex
3.7
6.3
20
57
D07XC01
ATC
betamethasone; topical
2.4
6.3
44
197
G44.2
ICD-10 Finland
Tension-type headache
2.1
6.1
63
331
D07AC01
ATC
betamethasone; topical
1.8
6.1
124
821
R53
ICD-10 Finland
Malaise and fatigue
1.9
6.1
99
612
Z51.6
ICD-10 Finland
Desensitization to allergens
10.3
6.1
11
11
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
6.1
108
687

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
115
459
3.31
22.21
1.6
1.4
444.14
544.44
titre
0.43
29
108
231
1508
2.77
16.23
8.0
6.0
0.04
0.04
e9/l
0.26
201
1286
230
1507
2.74
15.89
8.0
6.0
0.52
0.54
e9/l
0.93
203
1289
234
1553
2.74
15.64
8.0
6.0
1.96
2.01
e9/l
0.24
210
1365
235
1573
2.72
15.26
8.1
6.4
0.19
0.18
e9/l
0.56
210
1363
213
1402
2.46
13.63
7.8
5.9
55.46
56.32
%
0.62
205
1346
209
1377
2.41
13.15
8.0
6.0
0.67
0.71
%
0.58
198
1287
213
1421
2.41
12.94
8.0
5.9
30.09
29.47
%
0.47
206
1355
238
1672
2.52
12.82
10.2
9.7
3.81
3.95
e9/l
0.53
210
1452
208
1386
2.35
12.48
8.1
6.0
8.26
8.49
%
0.79
199
1306
207
1378
2.35
12.43
8.1
5.9
3.00
2.76
%
0.81
198
1293
42
136
3.39
10.89
1.7
2.2
1.70
5.31
iu/ml
—
7
28
220
1598
2.13
9.42
3.7
3.2
110.66
85.75
ug/l
1.17
209
1518
149
961
2.00
8.61
7.3
5.7
—
—
—
0
0
89
484
2.15
8.09
3.1
2.6
50.28
108.09
ug/g
3.17
75
379
120
752
1.94
7.26
1.5
1.5
2.51
2.14
g/l
1.03
87
485
102
609
1.98
7.09
1.4
1.3
6.55
7.97
u/ml
0.19
51
233
258
2088
2.08
7.03
9.0
7.7
73.47
77.08
u/l
0.93
252
1985
118
758
1.87
6.49
2.2
2.1
130.64
277.47
u/l
0.95
112
722
106
660
1.89
6.41
2.5
2.7
314.71
322.89
umol/l
0.40
99
592
308
2722
2.97
6.20
6.4
5.5
1.71
1.82
mu/l
1.11
300
2566
43
192
2.43
6.15
1.7
1.8
1.54
1.42
g/l
0.19
43
182
112
720
1.84
6.08
5.1
4.8
—
—
—
0
0
279
2370
2.15
6.02
5.3
4.5
14.34
14.49
pmol/l
0.52
268
2195
128
861
1.80
5.96
1.3
1.4
0.62
1.09
u/ml
1.48
33
252
103
649
1.85
5.94
1.6
1.3
28.73
28.18
iu/ml
0.02
27
197
29
111
2.77
5.65
1.2
1.2
—
—
—
0
0
23
79
3.05
5.42
1.3
1.0
3.00
2.30
u/ml
0.15
17
39
176
1324
1.71
5.35
3.3
2.5
72.04
75.54
nmol/l
0.98
170
1228
80
481
1.88
5.27
3.2
2.4
2.43
2.44
mmol/l
0.17
75
435
59
320
2.03
5.25
1.9
2.6
6.02
7.03
umol/l
0.26
53
282
54
284
2.08
5.22
1.5
1.2
88.27
174.03
u/ml
1.06
15
122
176
1331
1.69
5.19
11.1
9.5
0.00
0.00
e9/l
0.60
139
1071
13
24
5.59
4.96
1.5
1.5
1.35
2.87
u/ml
—
8
12
25
95
2.77
4.94
1.2
1.1
4.24
2.56
u/ml
0.39
19
51
151
1111
1.66
4.84
5.0
4.4
37.61
37.01
g/l
0.69
144
1063
122
852
1.69
4.76
6.9
6.1
—
—
—
0
0
127
911
1.64
4.40
3.0
2.9
2.36
2.36
mmol/l
0.02
118
844
140
1033
1.62
4.30
4.0
3.4
72.78
60.81
e6/l
0.10
100
680
152
1145
1.61
4.29
2.2
1.9
98.85
97.71
pmol/l
0.11
81
598
97
653
1.69
4.27
2.3
1.6
0.89
0.82
mg/l
0.16
73
495
72
447
1.78
4.22
4.4
3.5
52.15
622.73
ng/l
1.27
39
282
42
218
2.06
4.20
1.4
1.2
—
—
—
0
0
17
57
3.09
4.18
1.1
1.0
0.07
0.36
u/ml
0.43
11
16
113
799
1.63
4.09
2.8
2.6
—
—
—
0
0
17
58
3.04
4.07
1.0
1.1
—
—
—
0
0
153
1166
1.58
4.04
2.3
2.0
—
—
—
0
0
55
323
1.84
3.85
1.5
1.4
—
—
—
0
0
189
1523
1.56
3.84
3.7
3.3
0.00
0.00
estimate
0.50
41
321
120
872
1.59
3.84
3.2
2.8
26.39
50.66
e6/l
0.84
94
636
60
363
1.80
3.82
1.3
1.2
—
—
—
0
0
16
55
3.01
3.79
1.3
1.2
—
—
—
0
0
24
103
2.43
3.76
1.3
1.2
—
—
—
0
0
41
220
1.99
3.75
4.2
4.7
0.00
0.06
%
—
7
50
12
29
4.25
3.74
1.1
1.2
—
—
—
0
0
105
743
1.61
3.74
2.3
2.1
2.48
2.71
mg/l
0.51
91
649
40
217
1.96
3.55
2.0
2.4
24995.66
4705.99
u/l
1.14
15
94
189
1541
1.53
3.51
3.8
3.3
0.00
4.71
estimate
0.50
41
320
189
1547
1.52
3.41
3.8
3.4
0.00
0.00
estimate
-0.00
38
302
103
745
1.56
3.28
3.0
2.7
0.20
0.28
e6/l
0.33
76
512
40
225
1.89
3.20
4.3
4.4
0.14
0.48
%
—
7
59
292
2664
1.83
3.14
4.7
4.3
5.79
5.74
mmol/l
0.30
285
2496
18
74
2.52
3.10
1.4
1.3
—
—
—
0
0
62
403
1.66
3.05
2.6
2.2
2.38
2.40
g/l
0.13
55
377
41
237
1.83
3.02
4.2
4.6
0.57
0.70
%
—
7
68
69
462
1.62
3.02
1.5
1.6
—
—
—
0
0
40
230
1.84
3.00
2.2
2.3
19.84
13.59
au/ml
—
7
10
5
5
10.12
2.99
1.0
1.4
—
—
—
0
0
159
1281
1.47
2.95
5.5
6.2
1.22
1.22
mmol/l
0.08
144
1128
11
32
3.52
2.92
1.1
1.2
—
—
—
0
0
100
735
1.52
2.92
1.6
1.6
18.57
21.75
nmol/l
1.85
91
643
19
83
2.37
2.90
1.1
1.1
10.20
4.83
u/ml
0.58
12
48
154
1236
1.46
2.90
3.3
3.1
6.17
6.22
ph
0.20
82
694
40
233
1.82
2.88
4.6
5.1
0.00
0.12
%
—
6
51
309
2886
2.11
2.87
17.8
12.4
18.11
20.46
mg/l
0.76
273
2280
21
97
2.24
2.83
1.1
1.2
—
—
—
0
0
185
1542
1.45
2.83
5.1
4.3
6.39
6.41
mmol/l
0.06
178
1424
14
53
2.71
2.83
1.0
1.1
—
—
—
0
0
30
160
1.96
2.82
1.1
1.3
—
—
—
0
0
281
2555
1.67
2.81
21.5
15.9
333.85
332.64
g/l
1.91
281
2539
117
896
1.47
2.78
3.0
3.0
19.89
26.40
ng/l
0.39
51
513
17
74
2.37
2.62
2.2
2.4
1.00
2.03
index
0.51
11
39
7
15
4.74
2.61
1.3
1.7
70.00
68.87
umol/l
—
7
15
9
25
3.67
2.59
1.0
1.1
—
—
—
0
0
318
3018
2.48
2.58
19.8
15.2
70.87
70.53
umol/l
0.10
318
2981
111
852
1.46
2.57
3.2
2.4
57.76
63.49
u/l
0.48
104
802
20
95
2.18
2.54
1.9
1.7
19.73
20.16
s
0.23
15
83
112
867
1.44
2.47
2.1
2.2
—
—
—
0
0
281
2578
1.61
2.44
5.6
5.3
36.95
38.05
mmol/mol
2.02
276
2460
17
77
2.27
2.42
1.1
1.1
0.81
0.54
u/ml
—
10
34
5
8
6.32
2.38
1.0
1.3
0.36
6.04
u/ml
—
5
8
20
98
2.11
2.37
1.2
1.3
—
3.81
—
0
14
101
779
1.43
2.24
2.7
3.6
7.39
7.40
ph
0.19
69
538
141
1157
1.38
2.17
3.7
3.1
0.00
0.03
estimate
0.96
33
265
9
30
3.05
2.16
2.7
2.2
—
—
—
0
0
11
42
2.67
2.16
1.3
1.5
—
67.54
—
0
5
24
132
1.88
2.10
1.7
1.2
—
—
—
0
0
38
242
1.64
2.04
2.2
2.9
1.74
1.85
%
0.40
38
218
8
26
3.13
2.02
1.3
1.2
—
—
—
0
0
59
420
1.49
1.97
2.6
2.7
1.50
3.05
e6/l
1.58
26
185
138
1143
1.36
1.96
4.9
5.6
1.22
1.22
mmol/l
0.24
130
1075
5
11
4.60
1.95
1.6
1.0
—
—
—
0
0
5
11
4.60
1.95
1.6
1.0
—
—
—
0
0
5
11
4.60
1.95
1.6
1.0
—
—
—
0
0
6
16
3.80
1.94
1.5
1.7
3.23
2.93
mg/l
—
6
16
92
717
1.39
1.89
1.8
1.8
—
—
—
0
0
50
347
1.52
1.88
1.5
1.4
—
—
—
0
0
44
297
1.56
1.87
1.2
1.2
—
—
—
0
0
14
66
2.17
1.84
1.1
1.0
7.95
9.39
u/ml
—
8
26
128
1056
1.35
1.84
14.8
9.3
1.18
1.12
inr
0.64
105
857
87
677
1.39
1.80
3.9
3.3
—
0.00
—
0
6
29
178
1.69
1.80
1.8
2.9
76.92
73.39
e9/l
0.20
20
118
6
18
3.37
1.75
4.8
3.7
599.17
744.28
u/ml
—
6
18
7
24
2.96
1.73
2.1
2.2
1148.29
1644.47
e6/l
—
7
19
65
484
1.43
1.73
1.8
1.6
414.42
11820773.58
pmol/l
0.50
59
423
10
40
2.55
1.68
1.3
1.2
—
—
—
0
0
13
62
2.14
1.68
1.3
1.1
17.32
15.27
au/ml
—
5
21
15
76
2.02
1.67
1.1
1.1
—
—
—
0
0
15
76
2.02
1.67
1.0
1.3
275.49
213.17
u/ml
—
10
39
15
76
2.02
1.67
1.1
1.1
—
—
—
0
0
6
19
3.20
1.67
1.0
1.1
—
—
—
0
0
35
235
1.55
1.55
1.4
1.4
22.40
22.17
iu/l
0.01
26
197
106
871
1.32
1.52
3.0
2.7
0.09
0.02
estimate
0.33
32
249
6
21
2.89
1.51
1.8
2.1
38.30
41.47
%
—
6
21
17
94
1.85
1.50
1.2
1.3
—
—
—
0
0
5
16
3.16
1.44
1.4
1.3
187.38
110.48
iu/ml
—
5
16
27
174
1.60
1.42
1.1
1.1
—
—
—
0
0
49
360
1.42
1.41
1.7
1.7
1149.45
1146.30
nmol/l
0.01
39
270
9
40
2.28
1.41
2.1
4.7
3.87
4.23
e9/l
—
9
40
7
29
2.44
1.40
1.3
1.9
20.17
21.27
ng/l
—
7
29
6
23
2.64
1.37
2.7
2.3
333.17
182.33
e6/l
—
6
18
6
23
2.64
1.37
2.2
2.1
0.64
0.71
e9/l
—
6
23
42
304
1.44
1.32
1.3
1.4
—
—
—
0
0
9
43
2.12
1.31
4.2
2.3
39.67
32.13
umol/l
—
9
38
6
24
2.53
1.31
1.0
1.0
—
—
—
0
0
33
229
1.49
1.28
7.7
8.0
7.43
7.42
ph
0.48
14
130
27
180
1.54
1.25
1.1
1.1
—
—
—
0
0
6
25
2.43
1.25
3.8
3.2
26.43
17.72
mu/l
—
6
25
8
37
2.19
1.22
1.0
1.2
—
—
—
0
0
6
26
2.33
1.19
1.0
1.1
—
—
—
0
0
6
26
2.33
1.19
2.0
1.5
35.00
32.42
pg
—
6
26
11
57
1.96
1.18
2.2
3.8
56.45
59.04
%
0.22
11
57
21
134
1.61
1.17
10.8
9.5
1.05
1.32
%
0.91
21
134
42
312
1.40
1.16
1.4
1.6
—
—
—
0
0
5
20
2.52
1.15
1.0
1.1
1980.00
1653.95
miu/ml
—
5
20
5
20
2.52
1.15
1.2
1.2
91.20
104.45
pmol/l
—
5
20
20
127
1.61
1.14
11.1
9.9
0.53
0.66
%
1.31
20
127
9
46
1.98
1.04
3.2
2.4
6.88
6.60
pmol/l
—
9
46
5
22
2.29
1.03
1.8
3.4
—
—
—
0
0
7
34
2.08
1.03
1.4
1.6
—
—
—
0
0
9
47
1.94
1.03
1.8
2.6
209.19
5.93
u/ml
—
9
47
48
373
1.34
1.02
1.4
1.9
—
—
—
0
0
291
2792
1.36
1.01
5.2
4.5
4.81
4.74
mmol/l
0.63
285
2649
10
54
1.88
0.97
1.2
1.2
—
—
—
0
0
7
37
1.91
0.94
3.3
2.4
31.11
27.54
nmol/l
—
7
32
22
151
1.49
0.93
9.2
8.1
24.99
25.23
mmol/l
0.13
22
151
9
52
1.75
0.93
2.3
4.2
3.68
3.85
mmol/l
—
9
52
26
185
1.44
0.92
1.3
1.2
—
—
—
0
0
6
29
2.09
0.89
2.7
2.2
—
—
—
0
0
13
79
1.67
0.89
2.8
1.8
—
—
—
0
0
44
346
1.31
0.87
3.1
1.9
30.67
28.72
s
1.11
44
339
11
64
1.74
0.87
1.4
1.1
—
—
—
0
0
8
44
1.84
0.86
1.3
1.1
—
—
—
0
0
24
171
1.44
0.86
2.0
1.9
—
—
—
0
0
150
1357
1.19
0.84
2.7
2.6
—
—
estimate
—
0
0
11
65
1.72
0.83
1.8
1.9
—
—
—
0
0
11
66
1.69
0.79
1.5
2.2
55.29
63.06
%
0.50
11
66
24
174
1.41
0.79
1.7
2.3
69.59
67.61
g/l
0.68
24
163
10
59
1.72
0.76
1.2
1.9
53.20
62.02
%
—
10
59
11
67
1.66
0.76
1.0
1.3
—
—
—
0
0
12
75
1.62
0.76
1.1
1.4
—
—
—
0
0
95
832
1.20
0.76
4.3
3.3
0.00
0.01
estimate
0.80
39
300
41
327
1.29
0.75
1.7
1.4
—
—
—
0
0
18
125
1.47
0.74
2.7
3.0
195.85
125.47
ng/l
0.19
13
116
5
25
2.01
0.73
1.2
1.9
7.84
11.40
%
—
5
25
7
39
1.81
0.73
1.1
1.4
—
—
—
0
0
37
294
1.29
0.70
7.5
6.7
103.89
104.57
mmol/l
0.53
37
294
137
1246
1.17
0.70
2.6
2.8
—
—
—
0
0
27
207
1.33
0.66
9.7
7.8
—
—
—
0
0
290
2812
1.26
0.66
5.7
5.0
2.90
2.81
mmol/l
1.03
285
2663
14
95
1.49
0.65
1.2
1.2
—
—
—
0
0
20
147
1.38
0.63
1.5
2.2
—
—
—
0
0
79
692
1.19
0.63
4.0
3.3
1.02
1.02
kg/l
0.10
51
438
10
63
1.61
0.62
1.3
1.2
9.40
11.90
iu/ml
—
5
16
287
2785
1.23
0.61
5.1
4.4
1.47
1.50
mmol/l
0.51
281
2632
103
928
1.16
0.58
2.3
2.2
—
—
—
0
0
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
0
23
0.00
0.58
0.0
2.3
—
—
—
0
0
32
257
1.27
0.58
1.7
2.0
0.00
0.05
estimate
—
8
56
27
212
1.30
0.57
1.9
2.0
5.50
6.24
ph
4.29
12
136
272
2631
1.19
0.56
4.4
3.7
1.36
1.24
mmol/l
1.74
263
2474
6
40
1.51
0.52
1.2
1.3
—
—
—
0
0
18
233
0.76
0.49
1.7
1.8
—
—
—
0
0
15
111
1.37
0.47
2.4
2.1
—
—
—
0
0
10
68
1.49
0.47
1.1
1.4
133.00
154.13
au/ml
—
5
19
60
530
1.16
0.45
1.9
1.6
—
—
—
0
0
22
176
1.27
0.43
1.7
1.3
171.63
268.46
miu/ml
—
10
84
13
96
1.37
0.42
1.9
1.9
2.14
5.42
iu/l
—
6
41
128
1198
1.11
0.39
2.1
1.9
1.60
1.38
mmol/l
1.37
119
1050
36
308
1.19
0.39
4.8
5.4
1.05
1.07
mmol/l
0.15
29
284
5
35
1.43
0.39
1.8
1.3
—
—
—
0
0
27
225
1.22
0.38
3.0
2.5
0.59
0.68
ug/l
0.28
15
128
5
36
1.39
0.38
1.0
1.4
—
—
—
0
0
5
37
1.36
0.37
1.4
1.1
12.12
20.41
u/l
—
5
31
44
386
1.16
0.37
1.7
1.8
—
—
—
0
0
63
568
1.13
0.36
1.8
1.8
—
—
—
0
0
6
42
1.44
0.35
1.2
1.4
—
—
—
0
0
6
44
1.37
0.34
1.0
1.2
—
—
—
0
0
25
210
1.21
0.34
1.3
1.4
—
—
—
0
0
19
155
1.24
0.33
3.0
3.2
24.05
24.23
mmol/l
0.15
19
155
25
211
1.20
0.32
1.7
1.7
—
—
—
0
0
13
164
0.78
0.31
2.2
2.9
—
—
—
0
0
20
237
0.83
0.28
1.8
1.9
—
—
—
0
0
19
225
0.83
0.27
1.7
1.9
—
—
—
0
0
20
235
0.84
0.26
1.7
1.9
—
—
—
0
0
20
233
0.85
0.24
1.8
2.0
—
—
—
0
0
11
87
1.27
0.24
4.2
3.7
122.55
456.36
u/ml
0.49
11
77
13
106
1.24
0.23
2.1
4.5
—
—
—
0
0
19
162
1.18
0.23
1.6
1.5
0.33
0.27
mg/l
—
8
69
21
182
1.16
0.22
6.1
6.2
7.17
7.73
mmol/l
0.17
21
177
20
173
1.17
0.21
1.8
1.6
64.23
62.66
ug/l
0.05
15
148
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
17
145
1.18
0.21
1.6
2.1
0.00
0.02
estimate
—
8
49
10
80
1.26
0.20
11.1
8.0
—
—
—
0
0
16
136
1.19
0.20
1.8
2.6
0.50
0.60
%
1.18
16
136
17
195
0.86
0.18
1.8
2.0
—
—
—
0
0
20
226
0.88
0.17
5.0
4.7
5.25
26.95
ug/l
0.56
13
177
8
68
1.18
0.16
2.0
1.6
189.00
231.00
pmol/l
—
8
62
16
139
1.16
0.16
1.1
1.1
1.47
1.57
g/l
0.63
16
139
78
745
1.06
0.15
3.5
3.5
53.24
48.17
mg/l
0.07
51
466
27
246
1.11
0.15
3.1
3.2
5.94
5.71
kpa
0.92
27
241
15
131
1.15
0.14
1.8
1.5
1.27
1.27
mm
—
9
96
10
117
0.85
0.13
2.1
1.7
—
—
—
0
0
27
249
1.09
0.12
3.3
3.2
7.37
7.39
ph
1.06
15
136
302
2998
1.09
0.12
11.7
11.1
—
—
—
0
0
16
143
1.12
0.11
1.1
1.1
0.93
0.89
g/l
0.20
16
143
93
961
0.96
0.11
1.8
1.6
—
—
—
0
0
15
134
1.13
0.11
1.8
1.5
—
—
—
0
0
91
883
1.04
0.10
3.2
3.3
7.24
7.87
mmol/l
0.78
81
764
34
321
1.07
0.09
1.5
1.8
3.67
3.43
mmol/l
0.57
20
227
36
379
0.94
0.08
1.5
1.2
—
—
—
0
0
12
107
1.13
0.08
1.8
2.6
—
—
—
0
0
24
224
1.08
0.08
3.2
4.1
7.40
7.34
ph
0.35
18
171
7
67
1.05
0.08
3.7
5.7
1.67
1.18
mmol/l
—
7
57
15
137
1.10
0.07
1.9
1.6
—
—
—
0
0
8
94
0.85
0.07
1.3
1.3
—
—
—
0
0
59
605
0.97
0.05
3.7
4.1
—
—
—
0
0
29
302
0.96
0.04
1.9
1.6
964.67
969.07
mu/l
0.01
21
257
25
239
1.05
0.04
3.8
3.1
—
—
—
0
0
76
749
1.02
0.02
4.0
4.3
9.63
9.44
mg/mmol
0.01
51
455
39
385
1.01
0.00
1.3
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
1.65
—
0
6
0
6
0.00
0.00
0.0
4.2
—
41.42
—
0
6
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
1.21
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
64.00
—
0
5
0
7
0.00
-0.00
0.0
5.4
—
7.71
—
0
7
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
56.86
—
0
7
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
5
59
0.85
-0.00
1.4
2.9
7.40
7.41
ph
—
5
59
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
6.19
—
0
7
11
110
1.00
-0.00
3.8
3.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.7
—
48.71
—
0
7

Mortality – FinRegistry

↥

Association

Association between endpoint L12_URTICA_COLDHEAT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_URTICA_COLDHEAT.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: L12_URTICA_COLDHEAT – Urticaria due to cold and heat

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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