No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleonly females |
313377 |
2. Check conditionsNone |
313377 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
169 |
4. Check minimum number of eventsNone |
169 |
5. Include endpointsNone |
169 |
6. Filter based on genotype QC (FinnGen only) |
154 |
Control definitions (FinnGen only)
- Control exclude
- O15_MATERN_CARE
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF3
- Parent code in ICD-10
- O30-O48
- Name in latin
- Complicationes specificae plurifetationis
Similar endpoints
↥List of similar endpoints to
Complications specific to multiple gestation
based on the number of shared cases.
Similar with more cases:
- Maternal care related to the fetus and amniotic cavity and possible delivery problems
- Pregnancy, childbirth and the puerperium
- Any operation in hilmo
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 989 | 989 | - |
| Only index persons | 980 | 980 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | - |
| Only index persons | 0.04 | 0.04 | - |
| Median age at first event (years) | |||
| Whole population | - | 31.40 | - |
| Only index persons | - | 31.40 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 154 | 154 | - |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | - |
| Median age at first event (years) | 31.86 | 31.86 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 162
- Matched controls
- 1620
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O31.2
ICD-10 Finland
Continuing pregnancy after intrauterine death of one fetus or more
+∞
74.9
66
*
O30.0
ICD-10 Finland
Twin pregnancy
+∞
67.5
60
*
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
16.5
67.2
72
75
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
21.7
56.9
47
30
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
12.9
54.2
67
84
O31.8
ICD-10 Finland
Other complications specific to multiple gestation
+∞
43.7
40
*
O31.1
ICD-10 Finland
Continuing pregnancy after abortion of one fetus or more
+∞
42.6
39
*
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
8.1
40.3
88
208
O36.5
ICD-10 Finland
Maternal care for poor fetal growth
415.0
34.3
33
*
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
367.0
30.9
30
*
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
7.2
28.0
52
100
O32.1
ICD-10 Finland
Maternal care for breech presentation
+∞
27.9
26
*
Z39.2
ICD-10 Finland
Routine postpartum follow-up
5.8
27.8
79
227
O35.8
ICD-10 Finland
Maternal care for other (suspected) fetal abnormality and damage
+∞
25.7
24
*
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
5.4
25.3
81
254
O60
ICD-10 Finland
Preterm labour and delivery
35.8
25.2
32
11
O42.9
ICD-10 Finland
Premature rupture of membranes, unspecified
+∞
23.5
22
*
O30.00
ICD-10 Finland
Twin pregnancy with separate amniotic and chorionic sacs
+∞
21.3
20
*
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
8.1
20.8
31
46
W84
ICPC
Pregnancy high risk
8.7
20.2
28
38
O82.0
ICD-10 Finland
Delivery by elective caesarean section
32.5
19.4
25
9
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
4.3
18.9
98
424
SPAT1379
SPAT
Health check-up of pregnant person
4.6
18.0
57
171
G03GA01
ATC
chorionic gonadotrophin; parenteral
6.9
17.4
30
52
O84.2
ICD-10 Finland
Multiple delivery, all by caesarean section
+∞
17.0
16
*
O43.0
ICD-10 Finland
Placental transfusion syndromes
+∞
15.9
15
*
O30.01
ICD-10 Finland
Twin pregnancy with a shared chorionic sac and a separate amniotic sac
+∞
15.9
15
*
Z32.1
ICD-10 Finland
Pregnancy confirmed
4.3
15.8
53
164
SPAT1380
SPAT
Postpartum check-up
4.5
15.8
49
143
W78
ICPC
Pregnancy
3.8
15.6
74
292
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
4.1
15.2
55
180
O35.1
ICD-10 Finland
Maternal care for (suspected) chromosomal abnormality in fetus
+∞
14.8
14
*
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
164.2
14.7
15
*
O80.8
ICD-10 Finland
Other single spontaneous delivery
7.1
14.2
23
37
O42.0
ICD-10 Finland
Premature rupture of membranes, onset of labour within 24 hours
+∞
13.7
13
*
O31.0
ICD-10 Finland
Papyraceous fetus
+∞
13.7
13
*
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
3.6
13.5
62
236
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
5.1
13.4
32
75
SPAT1197
SPAT
Extensive health check-up of expecting family
3.6
12.9
58
217
O30.1
ICD-10 Finland
Triplet pregnancy
+∞
12.7
12
*
6460A
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Papyraceous foetus
+∞
12.7
12
*
Z34.9
ICD-10 Finland
Supervision of normal pregnancy, unspecified
3.8
12.6
50
172
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
5.8
12.2
24
47
MAA00
NOMESCO Finland
Amniocentesis
70.2
11.8
13
*
H01CC01
ATC
ganirelix; parenteral
6.1
11.7
22
41
Z36.0
ICD-10 Finland
Antenatal screening for chromosomal anomalies
4.8
11.6
29
70
O41.0
ICD-10 Finland
Oligohydramnios
+∞
11.6
11
*
O46.9
ICD-10 Finland
Antepartum haemorrhage, unspecified
+∞
11.6
11
*
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
4.0
11.1
37
112
MAJ00
NOMESCO Finland
Reduction of multiple pregnancy by one foetus
+∞
10.5
10
*
O48
ICD-10 Finland
Prolonged pregnancy
+∞
10.5
10
*
OAA11, ,
SPAT
4.3
10.4
30
81
ZXD05
NOMESCO Finland
Urgent procedure
2.9
9.9
67
313
O64.1
ICD-10 Finland
Obstructed labour due to breech presentation
58.6
9.8
11
*
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
8.6
9.5
20
26
O36.4
ICD-10 Finland
Maternal care for intrauterine death
+∞
9.5
9
*
XMA22
NOMESCO Finland
General examination of pregnant woman
4.4
9.4
26
68
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
25.7
9.0
12
5
O02.1
ICD-10 Finland
Missed abortion
4.1
8.5
26
73
O47.1
ICD-10 Finland
False labour at or after 37 completed weeks of gestation
94.8
8.5
9
*
O35.9
ICD-10 Finland
Maternal care for (suspected) fetal abnormality and damage, unspecified
+∞
8.4
8
*
O40
ICD-10 Finland
Polyhydramnios
+∞
8.4
8
*
O36.8
ICD-10 Finland
Maternal care for other specified fetal problems
+∞
8.4
8
*
G03GA05
ATC
follitropin alfa; parenteral
5.0
8.4
19
42
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
6.6
7.7
19
32
W90
ICPC
Uncompl labour/delivery livebirth
3.6
7.3
26
81
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
3.0
7.3
37
144
MAA54
NOMESCO Finland
Fetoscopy
+∞
7.3
7
*
O84.0
ICD-10 Finland
Multiple delivery, all spontaneous
+∞
7.3
7
*
G03GA06
ATC
follitropin beta; parenteral
6.6
7.3
18
30
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.6
7.2
26
82
OAA12, ,
SPAT
3.7
6.4
21
62
Z87.5
ICD-10 Finland
Personal history of complications of pregnancy, childbirth and the puerperium
18.9
6.3
9
5
O20.8
ICD-10 Finland
Other haemorrhage in early pregnancy
+∞
6.3
6
*
O42.1
ICD-10 Finland
Premature rupture of membranes, onset of labour after 24 hours
+∞
6.3
6
*
OAA10, ,
SPAT
3.8
6.2
20
58
O80.0
ICD-10 Finland
Spontaneous vertex delivery
2.3
6.2
85
528
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
43
167
3.14
8.66
1.7
1.5
1213.00
1153.60
mu/l
0.11
36
130
24
68
3.97
7.76
1.7
1.4
—
—
—
0
0
41
174
2.82
6.94
2.0
2.0
3472.60
3658.05
u/l
0.02
20
64
29
103
3.21
6.68
1.5
1.3
—
—
—
0
0
21
67
3.45
5.70
2.0
1.6
—
—
—
0
0
17
52
3.54
4.90
1.6
1.3
75.38
61.02
ug/l
0.44
17
52
69
447
1.95
4.06
3.0
2.4
0.00
0.04
estimate
0.68
25
113
9
17
5.54
3.56
1.9
1.3
—
—
—
0
0
87
649
1.74
2.98
2.9
2.5
—
—
estimate
—
0
0
58
386
1.78
2.96
3.6
3.0
0.00
0.01
estimate
0.50
32
132
79
575
1.73
2.95
3.5
2.8
16.70
0.04
estimate
0.49
30
119
7
17
4.25
2.38
1.9
1.5
6.43
8.75
mmol/l
—
7
17
43
292
1.64
1.96
2.8
4.2
7.97
13.21
mg/mmol
0.37
27
167
6
18
3.42
1.76
1.2
1.9
16.75
17.11
%
—
6
18
6
18
3.42
1.76
1.2
1.5
—
—
—
0
0
138
1250
1.70
1.61
4.4
3.9
—
—
—
0
0
63
492
1.46
1.49
2.2
1.6
—
—
—
0
0
5
121
0.39
1.44
1.8
4.4
—
—
—
0
0
90
758
1.42
1.39
3.9
3.2
0.00
0.00
estimate
-0.00
34
134
45
336
1.47
1.32
2.3
3.0
14.29
25.03
ng/l
0.49
14
140
6
24
2.56
1.31
2.5
2.1
6.12
6.42
pmol/l
—
6
24
90
764
1.40
1.30
3.9
3.2
34.53
0.00
estimate
0.49
34
135
90
767
1.39
1.25
3.9
3.2
0.00
0.00
estimate
-0.00
34
130
138
1272
1.57
1.23
14.2
13.6
13.41
13.31
%
0.57
138
1261
79
671
1.35
1.07
3.0
4.3
5.76
6.25
mmol/l
2.82
70
633
7
33
2.17
1.07
1.1
2.9
24.67
25.51
mmol/l
—
7
33
17
253
0.63
0.98
1.2
1.6
1.24
1.28
%
0.15
17
230
43
337
1.38
0.96
2.9
2.8
1.01
1.02
kg/l
0.54
31
219
0
32
0.00
0.96
0.0
4.5
—
24.39
—
0
32
28
203
1.46
0.96
1.4
1.7
3.61
3.28
mmol/l
1.09
23
137
8
45
1.82
0.85
1.4
1.3
—
—
—
0
0
15
97
1.60
0.85
2.0
3.1
—
—
—
0
0
0
24
0.00
0.80
0.0
1.2
—
—
—
0
0
33
259
1.34
0.73
1.6
1.8
3.39
3.18
ratio
0.52
28
192
59
504
1.27
0.71
1.7
1.5
—
—
—
0
0
15
104
1.49
0.65
1.4
1.4
—
—
—
0
0
14
96
1.50
0.64
1.2
1.3
—
—
—
0
0
14
97
1.49
0.61
1.2
1.4
1.27
1.17
ratio
—
9
50
14
97
1.49
0.61
1.2
1.4
0.96
0.97
ratio
—
9
50
14
97
1.49
0.61
1.2
1.4
1.46
1.45
ratio
—
9
50
0
22
0.00
0.60
0.0
1.2
—
—
—
0
0
0
22
0.00
0.60
0.0
1.2
—
—
—
0
0
8
53
1.54
0.59
2.4
1.3
—
—
—
0
0
6
36
1.69
0.57
1.3
3.1
48.00
55.45
%
—
6
36
39
327
1.25
0.54
1.4
1.3
1.35
19.73
u/ml
2.07
19
121
10
68
1.50
0.48
1.5
1.2
—
—
—
0
0
5
81
0.61
0.47
2.0
1.3
—
—
—
0
0
9
128
0.69
0.45
1.4
1.5
—
—
—
0
0
10
139
0.70
0.44
1.2
2.1
30.20
48.91
u/ml
—
10
133
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
2.4
—
355.48
—
0
8
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
5
34
1.49
0.40
2.2
2.0
13.40
12.94
%
—
5
34
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
17
136
1.28
0.35
1.6
6.2
0.98
1.04
mmol/l
0.47
17
123
12
91
1.34
0.35
1.6
1.7
—
—
—
0
0
6
47
1.29
0.32
1.0
2.2
1.45
1.27
%
—
6
47
41
365
1.17
0.32
2.1
2.2
2.86
2.51
mg/l
0.87
34
315
41
456
0.86
0.30
2.0
2.2
—
—
—
0
0
19
158
1.23
0.30
1.3
1.7
—
—
—
0
0
12
94
1.30
0.29
1.1
1.1
1.53
1.61
g/l
0.47
12
94
19
159
1.22
0.28
3.1
2.1
448.79
398.39
nmol/l
0.68
19
147
24
206
1.19
0.28
1.5
1.2
227.00
166.29
u/ml
0.35
11
82
12
95
1.28
0.27
1.1
1.2
0.92
0.85
g/l
0.72
12
95
5
72
0.68
0.26
1.2
1.4
—
—
—
0
0
79
835
0.89
0.26
8.6
9.3
4.45
3.82
e9/l
1.38
74
735
5
39
1.29
0.23
1.0
1.4
1.16
2.66
nmol/l
—
5
34
14
116
1.23
0.23
1.4
1.3
197.29
245.45
miu/ml
—
5
66
5
40
1.26
0.22
1.4
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
1.04
—
0
10
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
39
425
0.89
0.21
1.9
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
20
174
1.17
0.21
1.6
2.3
8.56
125.37
ng/l
—
9
70
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
24
268
0.88
0.19
1.7
1.8
—
—
—
0
0
50
469
1.10
0.17
1.4
1.3
1.02
1.40
u/ml
0.27
20
130
5
65
0.76
0.17
1.6
1.4
6.58
24.58
u/l
—
5
52
96
927
1.09
0.17
3.5
3.4
72.36
59.75
ug/l
0.36
96
893
30
326
0.90
0.15
1.8
1.9
—
—
—
0
0
60
570
1.08
0.15
1.9
1.8
1.38
1.33
mmol/l
0.15
52
517
14
121
1.17
0.15
1.1
1.0
—
—
—
0
0
32
296
1.10
0.14
2.4
2.1
—
—
—
0
0
131
1332
0.91
0.13
9.2
9.7
95.60
94.62
ml/min/173m2
0.27
122
1200
15
135
1.12
0.10
5.5
3.8
4.33
4.69
pmol/l
0.80
15
121
5
45
1.11
0.10
1.6
1.7
—
—
—
0
0
51
531
0.94
0.09
2.0
2.0
95.30
96.93
pmol/l
0.10
36
306
6
57
1.05
0.08
1.5
7.8
22.30
24.55
mmol/l
—
6
57
50
519
0.95
0.08
2.9
3.1
26.82
26.96
u/l
0.02
50
500
32
335
0.94
0.07
1.8
1.9
0.95
0.90
mg/l
0.05
22
250
11
99
1.12
0.06
1.3
1.5
—
—
—
0
0
143
1417
1.08
0.06
3.9
4.2
2.88
2.85
mmol/l
0.18
136
1377
123
1245
0.95
0.06
4.3
4.6
36.29
36.94
mmol/mol
0.41
118
1208
11
101
1.10
0.04
1.3
1.5
—
—
—
0
0
12
112
1.08
0.03
2.7
8.0
104.17
104.82
mmol/l
0.23
12
112
11
118
0.93
0.03
1.4
1.4
—
—
—
0
0
54
550
0.97
0.03
4.9
6.4
1.22
1.22
mmol/l
0.11
45
480
48
488
0.98
0.01
3.2
5.8
1.21
1.22
mmol/l
0.29
42
461
133
1323
1.03
0.01
2.9
3.3
1.21
1.17
mmol/l
0.27
126
1273
11
111
0.99
0.00
1.1
1.2
—
25.33
—
0
6
36
361
1.00
0.00
1.5
1.3
10.00
19.18
iu/ml
—
9
118
141
1407
1.02
0.00
3.6
4.0
4.84
4.80
mmol/l
0.21
135
1371
141
1407
1.02
0.00
3.6
3.9
1.51
1.53
mmol/l
0.24
136
1364
31
308
1.01
0.00
3.5
2.0
127.26
346.41
u/l
0.54
31
297
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
7
71
0.99
0.00
1.1
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
5.2
—
21.32
—
0
5
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
0.06
—
0
5
0
5
0.00
0.00
0.0
2.6
—
43.68
—
0
5
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
61.60
—
0
5
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1.02
—
0
6
142
1420
1.00
-0.00
11.9
10.8
13.47
18.09
mg/l
2.08
123
1099
7
75
0.93
-0.00
1.6
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
83
0.96
-0.00
1.3
1.5
2.15
2.70
ug/l
—
8
77
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
1953.67
—
0
9
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.00
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
1932.27
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint O15_MULTIP_GEST_COMPLIC and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have O15_MULTIP_GEST_COMPLIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: O15_MULTIP_GEST_COMPLIC – Complications specific to multiple gestation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data