Vitiligo: Generalized well circumscribed patches of leukoderma that are generally distributed over symmetric body locations and is due to autoimmune destruction of melanocytes.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
500 |
4. Check minimum number of eventsNone |
500 |
5. Include endpointsNone |
500 |
6. Filter based on genotype QC (FinnGen only) |
449 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L80-L99
- Name in latin
- Vitiligo
Similar endpoints
↥List of similar endpoints to
Vitiligo
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3372 | 1868 | 1488 |
| Only index persons | 3076 | 1720 | 1356 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.06 | 0.06 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 36.14 | 37.31 | 34.62 |
| Only index persons | 36.81 | 38.02 | 35.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 449 | 279 | 170 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.08 |
| Median age at first event (years) | 46.00 | 43.77 | 49.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 477
- Matched controls
- 4770
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L80
ICD-10 Finland
Vitiligo
11046.5
307.7
460
5
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.1
40.1
77
146
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
14.9
39.5
36
26
D07AD01
ATC
clobetasol; topical
3.4
27.4
119
420
D05AX02
ATC
calcipotriol; topical
7.1
26.4
41
62
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.9
23.4
145
624
E0000UV, ,
ATC
2.6
23.0
248
1405
70905
ICD-8 Finland
Other diseases of skin, Vitiligo
+∞
19.9
19
*
D07AC01
ATC
betamethasone; topical
2.4
18.5
210
1187
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
7.0
16.7
26
39
H03AA01
ATC
levothyroxine sodium; systemic
2.3
14.0
128
646
E03.89
ICD-10 Finland
Other specified hypothyroidism
4.7
13.0
31
70
L40.0
ICD-10 Finland
Psoriasis vulgaris
4.4
12.7
33
80
D02AX
ATC
Other emollients and protectives
5.1
11.3
24
49
TQW80
NOMESCO Finland
Local dermatologic skincare
8.6
10.9
23
28
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.7
10.7
63
257
D07AB08
ATC
desonide; topical
2.6
10.3
66
280
104
Kela drug reimbursment
Thyroid insufficiency
3.2
10.2
42
140
B81
ICPC
Anaemia vit B12/folate deficiency
4.6
9.2
22
50
D07AB02
ATC
hydrocortisone butyrate; topical
1.9
9.1
153
951
D07AC13
ATC
mometasone; topical
1.9
8.8
145
893
L43.8
ICD-10 Finland
Other lichen planus
11.0
8.3
15
14
107
Kela drug reimbursment
Pernicious anaemia
7.7
8.2
18
24
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.2
7.9
70
343
H02AB06
ATC
prednisolone; systemic
1.7
7.8
220
1578
L04AX03
ATC
methotrexate; systemic
2.4
7.8
55
244
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.9
7.8
112
657
B03BA03
ATC
hydroxocobalamin; parenteral
3.5
7.6
26
77
E000001, ,
ATC
1.9
7.6
103
593
K29.4
ICD-10 Finland
Chronic atrophic gastritis
7.8
7.4
16
21
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
7.8
7.4
16
21
H02AB07
ATC
prednisone; oral
2.2
7.3
66
326
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
7.3
7
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.3
7.2
57
266
J02AC01
ATC
fluconazole; systemic
1.7
7.1
195
1381
J31.0
ICD-10 Finland
Chronic rhinitis
2.3
7.0
55
256
B36.0
ICD-10 Finland
Pityriasis versicolor
6.5
7.0
17
27
D02AE01
ATC
carbamide; topical
2.8
7.0
35
131
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.6
6.9
39
156
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.0
6.9
30
104
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
8.4
6.9
14
17
L63.8
ICD-10 Finland
Other alopecia areata
17.0
6.8
10
6
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
3.7
6.7
21
59
L04AA13
ATC
[U] leflunomide
5.5
6.5
18
34
D05AX52
ATC
calcipotriol, combinations; topical
2.9
6.5
31
113
D07XC01
ATC
betamethasone; topical
2.2
6.5
58
285
7090F
ICD-9 Finland
Other disorders of skin and subcutaneous tissue, Dyschromia[VITILIGO]
+∞
6.3
6
*
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
+∞
6.3
6
*
D05BA02
ATC
methoxsalen; oral
+∞
6.3
6
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
6.2
180
1282
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
6.4
6.2
15
24
J01MA02
ATC
ciprofloxacin; systemic
1.7
6.2
160
1106
XQ848
NOMESCO Finland
Dermatological photography
3.9
6.1
18
48
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
87
348
2.83
15.54
1.4
1.2
183.53
170.60
u/ml
0.10
36
146
54
198
2.95
11.19
4.3
1.7
5.32
5.53
iu/ml
—
10
40
24
52
4.81
10.59
3.9
4.7
51.94
37.11
u/ml
—
9
19
178
1122
1.94
10.38
1.5
1.3
0.70
2.13
u/ml
2.04
45
303
388
3314
1.92
7.10
6.3
4.2
14.84
14.54
pmol/l
1.66
366
3075
434
3874
2.33
6.81
7.3
5.1
1.88
1.83
mu/l
0.32
419
3628
63
332
2.03
5.89
1.3
1.3
581.24
224.49
u/ml
0.61
58
307
238
1833
1.60
5.88
3.0
2.5
76.02
75.37
nmol/l
0.14
222
1675
30
115
2.72
5.76
1.1
1.2
—
0.93
—
0
6
100
619
1.78
5.73
2.8
2.7
241.41
121.79
ug/g
0.93
76
506
241
1900
1.54
5.13
8.4
6.9
1.22
1.21
mmol/l
0.91
214
1652
16
45
3.64
5.09
1.3
1.2
—
—
—
0
0
291
2401
1.54
4.96
11.3
9.9
3.81
4.01
e9/l
1.02
264
2087
16
46
3.56
4.93
1.3
1.2
—
—
—
0
0
16
46
3.56
4.93
1.3
1.2
—
—
—
0
0
357
3090
1.62
4.89
5.7
4.1
9.91
10.23
mm/h
0.22
338
2904
30
127
2.45
4.75
1.2
1.2
—
—
—
0
0
356
3100
1.58
4.54
9.1
7.7
76.95
76.99
u/l
0.01
347
2948
28
119
2.44
4.41
1.6
1.4
223.89
313.42
ug/g
1.35
18
58
212
1663
1.49
4.41
5.3
4.7
36.84
36.61
g/l
0.30
207
1582
15
45
3.41
4.36
1.3
1.2
—
—
—
0
0
16
51
3.21
4.24
1.3
1.2
—
—
—
0
0
16
52
3.15
4.12
1.1
1.3
—
—
—
0
0
9
14
6.53
4.00
1.1
1.1
88.44
96.93
%
—
9
14
418
3832
1.73
3.86
6.1
5.6
38.56
38.39
mmol/mol
0.14
396
3633
267
2232
1.45
3.81
4.1
3.5
0.00
0.00
estimate
-0.00
48
468
16
55
2.98
3.77
1.3
1.2
—
—
—
0
0
136
1005
1.49
3.66
2.6
2.2
2.85
2.71
mg/l
0.26
119
869
11
25
4.48
3.64
1.2
1.1
—
—
—
0
0
264
2218
1.43
3.57
4.1
3.5
0.00
0.00
estimate
-0.00
51
463
267
2248
1.43
3.56
4.2
3.6
0.00
0.69
estimate
0.50
49
436
212
1713
1.43
3.56
7.4
6.3
1.22
1.22
mmol/l
0.59
201
1591
16
57
2.87
3.55
1.3
1.4
—
—
—
0
0
13
36
3.68
3.52
3.5
1.7
230.25
190.10
e6/l
—
8
29
82
546
1.61
3.52
1.5
1.6
1052.44
1151.20
nmol/l
0.48
60
415
207
1669
1.42
3.50
2.2
2.0
96.92
96.00
pmol/l
0.09
108
873
164
1268
1.45
3.48
2.4
2.5
57.14
64.22
u/l
0.72
153
1193
13
37
3.58
3.42
3.5
1.6
458.00
532.89
e6/l
—
8
27
15
55
2.78
3.18
1.5
1.7
232.24
30.37
ng/l
1.17
15
55
92
644
1.53
3.17
2.6
2.2
12.92
13.96
umol/l
0.82
87
608
254
2149
1.39
3.14
3.5
2.9
98.58
107.22
ug/l
0.37
237
2039
11
31
3.61
3.01
2.5
2.2
—
—
—
0
0
10
26
3.91
2.99
1.5
1.3
—
—
—
0
0
267
2292
1.37
2.94
5.0
4.8
6.80
6.49
mmol/l
1.24
246
2138
131
1004
1.42
2.84
2.3
2.6
333.39
334.71
umol/l
0.05
121
908
458
4381
2.14
2.79
19.7
16.7
80.56
73.43
umol/l
1.76
452
4330
25
125
2.06
2.76
2.6
2.0
2.31
4.79
iu/l
1.18
11
49
32
176
1.88
2.71
1.5
1.6
5.38
5.51
u/ml
—
9
42
30
162
1.91
2.69
1.6
1.5
—
—
—
0
0
108
808
1.44
2.66
1.4
1.3
18.74
9.34
u/ml
0.41
41
322
87
627
1.47
2.60
2.2
3.6
0.82
0.82
mmol/l
0.08
79
603
436
4124
1.67
2.54
16.5
13.4
18.37
22.31
mg/l
2.53
362
3312
101
755
1.43
2.49
1.7
1.7
418.71
28744764.95
pmol/l
0.77
86
661
52
339
1.60
2.45
3.4
4.7
3.11
20.42
ug/l
0.77
42
279
114
874
1.40
2.44
1.4
1.4
23.07
28.21
iu/ml
0.30
34
262
91
673
1.44
2.38
2.0
2.1
—
—
—
0
0
416
3906
1.51
2.36
5.0
4.6
5.88
5.83
mmol/l
0.27
390
3644
455
4367
1.91
2.35
13.7
10.9
25.06
26.88
u/l
2.29
450
4259
28
156
1.84
2.31
1.6
1.6
—
—
—
0
0
243
2105
1.31
2.30
5.7
6.3
10.95
10.99
umol/l
0.02
237
2017
435
4129
1.61
2.29
17.6
15.0
3.94
3.95
mmol/l
0.35
430
4039
112
867
1.38
2.26
3.2
2.5
8.24
6.44
e6/l
0.22
103
787
98
742
1.40
2.25
2.1
2.3
—
—
—
0
0
22
114
1.97
2.24
3.4
2.4
13.93
11.81
mg/l
0.63
22
109
67
473
1.48
2.23
2.5
2.7
6.35
7.31
umol/l
0.22
62
411
135
1079
1.35
2.22
1.6
1.6
20.49
21.11
nmol/l
0.19
113
926
434
4123
1.58
2.20
17.4
14.9
139.75
139.70
mmol/l
0.21
429
4045
12
49
2.49
2.12
1.3
1.1
—
—
—
0
0
39
247
1.63
2.09
2.1
2.3
4.79
7.96
ug/l
0.98
33
223
160
1322
1.32
2.08
2.7
3.3
2.36
2.36
mmol/l
0.23
149
1220
65
465
1.46
2.03
4.7
4.4
31.27
31.47
%
0.05
45
312
419
3969
1.46
1.96
14.3
12.6
85.29
87.23
ml/min/173m2
1.11
387
3632
135
1099
1.32
1.94
4.3
3.0
0.24
0.36
e6/l
0.72
100
793
42
277
1.57
1.92
6.2
3.4
105.46
72.80
ng/l
1.13
34
250
40
261
1.58
1.91
1.1
1.0
—
—
—
0
0
67
489
1.43
1.89
7.8
5.4
1.06
1.04
mmol/l
0.30
62
458
51
353
1.50
1.88
2.2
2.6
0.23
0.22
g/l
0.47
46
331
15
72
2.12
1.88
1.7
1.2
4.63
3.55
u/ml
—
8
33
325
2971
1.29
1.87
3.7
3.4
—
—
—
0
0
5
12
4.20
1.82
1.4
2.1
157.40
144.00
%
—
5
12
15
73
2.09
1.82
1.7
1.2
1.25
2.38
u/ml
—
8
26
7
23
3.07
1.80
1.9
2.6
640.57
523.35
u/ml
—
7
23
33
210
1.61
1.76
1.4
1.7
—
—
—
0
0
153
1282
1.28
1.76
4.1
3.1
70.00
104.06
e6/l
0.23
121
966
9
36
2.53
1.74
1.2
1.1
65.00
54.79
u/l
—
9
31
15
75
2.03
1.71
2.4
3.5
4.77
7.96
pmol/l
1.69
15
75
6
19
3.18
1.66
7.2
2.4
—
—
—
0
0
6
19
3.18
1.66
1.0
1.1
—
—
—
0
0
6
19
3.18
1.66
7.2
2.4
—
—
—
0
0
6
19
3.18
1.66
1.0
1.1
—
—
—
0
0
328
3022
1.27
1.66
3.6
3.3
40.54
42.67
u/l
0.22
314
2896
19
106
1.83
1.61
1.3
1.1
—
—
—
0
0
118
971
1.29
1.55
2.1
2.3
—
—
—
0
0
38
259
1.51
1.54
1.7
1.5
—
—
—
0
0
42
293
1.48
1.52
2.5
2.6
70.00
72.74
ml/min/173m2
0.21
18
126
52
381
1.41
1.47
6.5
9.5
-0.16
0.88
mmol/l
0.69
39
320
10
46
2.20
1.41
1.7
1.1
—
—
—
0
0
14
74
1.92
1.40
3.8
2.0
—
—
—
0
0
6
23
2.63
1.37
1.0
1.1
—
—
—
0
0
6
23
2.63
1.37
1.0
1.1
—
—
—
0
0
75
593
1.31
1.33
1.7
1.9
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
5
18
2.80
1.29
1.4
1.7
144.20
127.11
%
—
5
18
8
35
2.31
1.27
1.5
1.9
—
—
—
0
0
77
615
1.30
1.27
3.7
2.9
1.76
2.94
e6/l
1.10
36
288
16
92
1.76
1.26
1.3
1.3
—
—
—
0
0
465
4556
1.82
1.24
26.1
20.6
4.54
4.55
e12/l
0.05
460
4471
116
978
1.25
1.24
3.9
3.6
1.02
1.02
kg/l
1.24
78
635
427
4117
1.35
1.23
5.4
4.7
4.72
4.71
mmol/l
0.05
407
3891
20
124
1.64
1.22
1.1
1.3
—
—
—
0
0
82
664
1.28
1.22
3.7
2.7
1.03
0.89
e6/l
0.13
42
332
191
1699
1.21
1.21
3.7
3.4
0.00
0.01
estimate
1.34
41
393
43
317
1.39
1.20
1.6
1.5
—
—
—
0
0
112
946
1.24
1.18
1.8
1.7
0.91
1.16
mg/l
0.64
90
732
160
1404
1.21
1.16
3.5
3.4
24.89
82.05
ng/l
0.68
104
889
5
20
2.52
1.15
1.8
4.2
60.40
160.75
nmol/l
—
5
20
29
200
1.48
1.15
6.1
9.3
24.25
24.53
mmol/l
0.13
29
190
12
65
1.87
1.14
2.7
1.9
12.83
13.14
%
0.54
12
65
24
159
1.54
1.14
1.3
1.4
—
—
—
0
0
22
143
1.56
1.13
2.6
2.1
100.59
95.21
%
0.57
22
137
47
356
1.36
1.12
2.1
3.0
—
—
—
0
0
425
4105
1.32
1.12
5.2
4.6
1.50
1.47
mmol/l
0.75
403
3865
47
357
1.35
1.11
2.4
2.0
—
—
—
0
0
37
270
1.40
1.10
2.5
3.8
1.22
1.23
mmol/l
0.03
29
235
24
161
1.52
1.09
1.5
1.3
—
—
—
0
0
17
105
1.64
1.07
1.8
3.1
3.33
1.94
index
—
9
65
44
333
1.35
1.06
6.9
10.2
123.39
122.67
g/l
0.09
44
326
41
307
1.37
1.06
1.8
2.4
0.11
0.14
e6/l
0.26
41
294
5
22
2.29
1.03
1.0
1.7
—
0.87
—
0
5
50
388
1.32
1.03
6.6
9.3
12.02
12.65
kpa
0.39
50
375
50
388
1.32
1.03
6.7
9.3
4.97
5.13
kpa
0.59
50
374
152
1341
1.20
1.03
5.3
3.4
7.89
8.10
mmol/l
0.23
142
1147
5
23
2.19
0.98
1.6
1.5
14.00
15.17
u/l
—
5
23
5
23
2.19
0.98
1.0
1.0
—
—
—
0
0
7
36
1.96
0.97
1.1
1.0
—
—
—
0
0
209
1904
1.17
0.97
2.6
2.7
—
—
estimate
—
0
0
9
51
1.78
0.95
1.0
1.3
—
—
—
0
0
9
51
1.78
0.95
1.1
1.2
95.22
98.33
%
—
9
46
6
27
2.24
0.93
1.3
2.7
0.50
0.78
index
—
6
27
6
28
2.16
0.92
8.7
2.5
—
—
—
0
0
136
1202
1.18
0.90
4.8
4.1
5.72
8.84
mg/mmol
0.48
90
741
15
95
1.60
0.88
1.3
3.2
1.06
1.74
ratio
—
9
53
31
231
1.37
0.85
2.8
2.3
15712.14
5973.17
u/l
0.41
14
101
28
205
1.39
0.85
1.6
1.5
—
—
—
0
0
28
205
1.39
0.85
8.1
11.5
16.53
16.07
%
0.40
28
197
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
13
80
1.64
0.85
3.4
2.7
0.45
0.35
iu/ml
—
7
41
194
1772
1.16
0.85
2.1
1.9
1.35
1.39
mmol/l
0.26
169
1547
19
129
1.49
0.84
1.8
2.0
—
—
—
0
0
11
65
1.71
0.83
1.1
1.1
123.91
116.38
%
0.34
11
58
427
4155
1.26
0.82
5.9
5.3
2.79
2.79
mmol/l
0.01
406
3918
113
993
1.18
0.80
2.7
3.0
679.16
862.36
ng/l
0.66
94
828
403
3901
1.21
0.80
4.5
4.0
1.23
1.29
mmol/l
0.93
377
3651
0
24
0.00
0.79
0.0
1.1
—
111.70
—
0
24
51
414
1.26
0.78
5.9
5.5
—
—
—
0
0
115
1017
1.17
0.75
1.8
1.7
—
—
—
0
0
135
1210
1.16
0.75
4.4
3.6
0.00
0.01
estimate
0.50
46
438
5
25
2.01
0.73
1.0
1.2
11.20
8.72
mm/h
—
5
25
5
25
2.01
0.73
1.2
1.2
—
—
—
0
0
5
25
2.01
0.73
1.2
2.4
133.40
94.04
%
—
5
25
7
39
1.81
0.72
1.4
1.2
—
—
—
0
0
7
40
1.76
0.71
1.4
1.2
—
—
—
0
0
18
126
1.45
0.71
1.7
1.7
—
—
—
0
0
5
26
1.93
0.71
1.0
1.3
—
—
—
0
0
5
26
1.93
0.71
2.8
1.2
8.54
5.43
umol/l
—
5
19
17
118
1.46
0.70
1.5
1.5
427.47
456.69
mg/l
0.18
17
111
5
28
1.79
0.66
12.4
8.6
—
50.00
—
0
10
19
137
1.40
0.65
4.7
5.0
1.41
1.29
mg/l
0.23
19
127
166
1524
1.14
0.65
3.5
3.2
35.04
31.27
u/l
0.20
159
1461
7
44
1.60
0.65
1.1
2.0
—
—
—
0
0
48
572
0.82
0.62
1.8
1.9
3.83
3.54
ratio
0.60
34
447
90
795
1.16
0.61
1.8
1.5
—
—
—
0
0
51
429
1.21
0.60
2.6
2.1
—
—
—
0
0
8
53
1.52
0.58
1.1
1.0
—
—
—
0
0
8
53
1.52
0.58
1.0
1.3
—
—
—
0
0
8
54
1.49
0.57
1.0
1.3
—
—
—
0
0
8
54
1.49
0.57
1.0
1.3
—
—
—
0
0
8
55
1.46
0.56
1.0
1.3
—
—
—
0
0
58
499
1.18
0.55
7.7
7.1
103.97
104.64
mmol/l
0.54
58
499
16
117
1.38
0.53
1.2
1.1
—
—
—
0
0
12
83
1.46
0.52
1.3
1.3
178.00
143.00
au/ml
—
5
24
6
41
1.47
0.50
1.7
1.5
—
—
—
0
0
14
101
1.40
0.50
1.5
1.5
76.55
48.91
ug/l
0.74
14
101
26
208
1.26
0.49
1.2
1.4
257.44
235.28
miu/ml
—
9
95
7
46
1.53
0.48
1.0
4.0
18.43
54.00
u/ml
—
7
46
11
76
1.46
0.48
1.5
1.3
3.49
2.93
ug/l
0.22
11
69
14
102
1.38
0.48
1.6
1.3
0.14
0.40
nmol/l
—
9
78
80
717
1.14
0.46
2.2
2.6
2.44
2.44
mmol/l
0.11
73
644
52
451
1.17
0.46
1.7
1.8
—
—
—
0
0
41
348
1.19
0.46
7.0
3.7
1.55
1.74
mmol/l
0.12
35
290
7
49
1.43
0.46
1.1
1.9
—
—
—
0
0
12
86
1.41
0.45
1.4
1.4
—
—
—
0
0
8
56
1.44
0.42
1.0
1.3
—
—
—
0
0
8
56
1.44
0.42
1.0
1.3
—
—
—
0
0
137
1276
1.10
0.42
2.8
2.9
0.00
0.07
estimate
0.55
38
375
17
215
0.78
0.40
1.1
1.1
1.46
1.55
g/l
0.61
17
215
10
71
1.42
0.39
1.2
1.1
—
—
—
0
0
10
71
1.42
0.39
2.5
4.4
—
3519.57
—
0
7
5
35
1.43
0.39
1.0
1.3
6.46
7.11
u/l
—
5
30
18
225
0.79
0.39
1.3
1.6
0.14
0.32
mg/l
—
9
102
16
125
1.29
0.37
1.2
1.1
0.28
4.07
u/ml
2.73
11
67
13
99
1.32
0.36
1.5
1.4
—
—
—
0
0
44
387
1.15
0.35
2.5
2.5
28.71
30.57
u/l
0.37
35
328
29
246
1.19
0.35
1.2
1.3
—
—
—
0
0
78
713
1.11
0.34
3.9
3.4
222.85
416.65
ng/l
0.58
61
497
35
303
1.17
0.34
1.3
1.4
25.67
24.42
iu/l
0.08
27
261
6
45
1.34
0.34
4.0
4.1
—
—
—
0
0
15
118
1.28
0.34
1.7
1.8
—
—
—
0
0
18
219
0.81
0.32
1.3
1.1
0.87
0.90
g/l
0.34
18
219
15
120
1.26
0.30
1.9
3.0
—
—
—
0
0
26
222
1.18
0.30
6.2
3.3
2.34
1.70
mmol/l
0.31
18
158
41
364
1.14
0.29
7.1
3.7
5.56
5.74
kpa
0.55
41
356
48
432
1.12
0.28
1.7
1.9
—
—
—
0
0
39
435
0.89
0.26
1.5
1.7
3.85
3.51
mmol/l
0.91
22
308
17
141
1.21
0.26
1.5
1.7
—
—
—
0
0
11
86
1.29
0.26
1.5
1.3
—
—
—
0
0
9
72
1.25
0.25
1.2
1.3
—
—
—
0
0
5
40
1.25
0.22
1.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
5
43
1.16
0.21
1.0
1.2
—
—
—
0
0
57
613
0.92
0.20
2.8
2.9
0.71
0.73
ug/l
0.09
35
364
14
117
1.20
0.20
1.5
1.6
—
—
—
0
0
6
48
1.25
0.20
1.0
1.2
—
—
—
0
0
14
118
1.19
0.19
1.2
1.1
—
—
—
0
0
24
215
1.12
0.17
1.4
1.5
224.90
277.67
mu/l
0.90
24
196
8
68
1.18
0.16
1.6
1.4
—
—
—
0
0
8
71
1.13
0.16
1.5
1.4
—
—
—
0
0
8
71
1.13
0.16
1.5
1.4
—
—
—
0
0
77
807
0.95
0.15
4.2
4.0
22.98
21.40
%
0.32
32
356
32
299
1.08
0.11
1.6
1.6
1073.62
985.40
mu/l
0.20
27
253
33
309
1.07
0.11
6.5
3.4
5.53
4.66
kpa
0.64
33
302
13
146
0.89
0.10
1.5
1.3
—
—
—
0
0
18
196
0.92
0.09
1.7
1.7
2.89
3.05
mg/l
0.06
18
144
15
165
0.91
0.09
1.7
1.5
—
—
—
0
0
6
58
1.03
0.08
1.2
1.1
—
—
—
0
0
6
58
1.03
0.08
1.2
1.1
—
—
—
0
0
10
88
1.14
0.08
1.8
1.5
—
—
—
0
0
8
77
1.04
0.07
1.3
1.4
—
—
—
0
0
358
3601
0.98
0.06
20.5
16.8
13.46
13.45
%
0.06
352
3569
15
159
0.94
0.03
6.9
7.3
1.61
1.55
%
0.14
15
149
17
179
0.95
0.03
1.4
1.9
—
—
—
0
0
10
107
0.93
0.02
1.1
1.2
—
—
—
0
0
11
116
0.95
0.00
1.6
1.5
—
—
—
0
0
16
166
0.96
0.00
1.7
1.5
0.95
0.96
ratio
—
9
108
16
166
0.96
0.00
1.7
1.5
1.00
1.19
ratio
—
9
108
16
166
0.96
0.00
1.7
1.5
1.20
1.14
ratio
—
9
108
20
195
1.03
0.00
1.5
1.5
—
—
—
0
0
16
163
0.98
0.00
1.7
1.9
37.56
39.45
nmol/l
0.14
16
157
23
231
1.00
0.00
10.5
3.8
23.81
24.18
mmol/l
0.33
23
231
0
5
0.00
-0.00
0.0
15.0
—
10.24
—
0
5
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
7
74
0.95
-0.00
1.9
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
12.9
—
5.86
—
0
7
7
79
0.88
-0.00
1.4
1.8
—
—
—
0
0
5
55
0.91
-0.00
2.2
1.4
—
—
—
0
0
10
100
1.00
-0.00
1.2
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
1.29
—
0
8
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
6.07
—
0
7
6
68
0.88
-0.00
1.5
1.4
6.83
7.05
mmol/l
—
6
56
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
7
74
0.95
-0.00
1.0
1.1
—
1.96
—
0
14
102
1020
1.00
-0.00
4.3
4.6
1.70
2.35
ug/l
0.85
93
922
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_VITILIGO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_VITILIGO | 1.203 [0.93, 1.55] | 0.156 |
| Birth year | 0.994 [0.99, 1.0] | 0.165 |
During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 1518 females with L12_VITILIGO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_VITILIGO | 1.183 [0.94, 1.49] | 0.157 |
| Birth year | 0.988 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 1189 males with L12_VITILIGO died.
Mortality risk
Mortality risk for people of age
years, who have L12_VITILIGO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.11% | 0.247% |
| 5 | 0.704% | 1.539% |
| 10 | 1.552% | 3.646% |
| 15 | 3.01% | 6.626% |
| 20 | 5.436% | 10.822% |
Relationships between endpoints
↥Index endpoint: L12_VITILIGO – Vitiligo
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data