Disorders of optic nerve, not elsewhere classified

H7_OPTNERVNAS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H47.0
  • Hospital discharge: ICD-9 3774
  • Hospital discharge: ICD-8 37799
  • Cause of death: ICD-10 H47.0
  • Cause of death: ICD-9 3774
  • Cause of death: ICD-8 37799

2 out of 7 registries used, show all original rules.

853

4. Check minimum number of events

None

853

5. Include endpoints

None

853

6. Filter based on genotype QC (FinnGen only)

767

Control definitions (FinnGen only)

Control exclude
H7_OPTNERVE

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H47
Name in latin
Morbositates nervi optici non alibi classificatae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5048 2489 2516
Only index persons 4410 2212 2198
Unadjusted period prevalence (%)
Whole population 0.07 0.07 0.07
Only index persons 0.08 0.08 0.08
Median age at first event (years)
Whole population 62.97 63.63 62.38
Only index persons 62.67 63.16 62.18

-FinnGen-

Key figures

All Female Male
Number of individuals 767 383 384
Unadjusted period prevalence (%) 0.16 0.14 0.18
Median age at first event (years) 63.09 60.31 65.86

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
791
Matched controls
7910
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
+∞
307.7
744
*
XCK00
NOMESCO Finland
Perimetry
13.9
228.5
246
248
H47.1
ICD-10 Finland
Papilloedema, unspecified
1713.2
150.0
141
*
H46
ICD-10 Finland
Optic neuritis
+∞
123.2
115
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
56.0
108.9
62
12
H53.4
ICD-10 Finland
Visual field defects
14.5
98.0
92
71
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.2
76.9
290
963
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
8.5
76.9
106
141
H47.2
ICD-10 Finland
Optic atrophy
+∞
70.9
67
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.8
70.4
193
500
XCK10
NOMESCO Finland
Photography of fundus of eye
4.9
68.8
183
462
G35
ICD-10 Finland
Multiple sclerosis
24.3
66.6
48
21
CS494
NOMESCO Finland
Other visual field testing
10.1
65.9
78
85
XCD10
NOMESCO Finland
Electrophysiological examination of eye
10.0
63.1
75
82
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
5.6
61.0
130
270
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.3
59.1
184
521
H53.1
ICD-10 Finland
Subjective visual disturbances
5.1
55.2
130
294
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
19.7
54.7
43
23
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.6
52.6
143
363
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
8.6
51.9
69
87
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
13.9
43.7
41
31
H47.3
ICD-10 Finland
Other disorders of optic disc
+∞
42.1
40
*
37799
ICD-8 Finland
Other diseases of retina and optic nerve, Unspecified
+∞
41.0
39
*
TAB00
NOMESCO Finland
Lumbar puncture
5.1
37.8
84
179
H53.9
ICD-10 Finland
Visual disturbance, unspecified
5.0
32.4
73
157
PAW37
NOMESCO Finland
Biopsy of temporal artery
30.6
28.8
38
13
Z3229
NOMESCO Finland
Other healthcare associate professional
3.3
27.8
116
390
109
Kela drug reimbursment
Multiple sclerosis
29.5
25.6
34
12
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
5.6
25.2
49
92
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
35.8
24.4
31
9
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
32.2
23.9
31
10
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.9
22.0
113
427
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
82.5
21.8
24
*
AA1AD
NOMESCO Finland
CT of head and brain
2.1
20.5
298
1785
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
6.6
20.2
33
52
XCD20
NOMESCO Finland
Photoangiography of eye
6.4
19.0
32
52
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.3
19.0
171
844
Z3231
NOMESCO Finland
Registered nurse
2.0
17.8
252
1481
H34.1
ICD-10 Finland
Central retinal artery occlusion
19.2
17.4
26
14
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
12.9
17.2
30
24
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
28.2
16.6
22
8
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
4.8
16.5
38
83
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
15.6
435
3155
N86
ICPC
Multiple sclerosis
32.4
14.9
19
6
S01EC01
ATC
acetazolamide; systemic
4.3
13.5
35
84
R51.80
ICD-10 Finland
Headache
2.1
13.4
141
734
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
13.3
133
679
F05
ICPC
Visual disturbance other
3.6
12.6
43
126
L04AX07
ATC
dimethyl fumarate; oral
71.0
12.6
14
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.0
12.6
166
936
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
10.3
12.5
24
24
H02AB06
ATC
prednisolone; systemic
1.7
12.4
400
2951
A10AB05
ATC
insulin aspart; parenteral
2.5
12.3
81
345
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
3.3
12.3
48
154
L03AB07
ATC
interferon beta-1a; parenteral
38.2
12.2
15
*
G93.2
ICD-10 Finland
Benign intracranial hypertension
38.2
12.2
15
*
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
21.7
12.0
17
8
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.7
11.4
65
258
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
2.8
11.3
58
218
H54.4
ICD-10 Finland
Blindness, monocular
20.4
11.2
16
8
H34.8
ICD-10 Finland
Other retinal vascular occlusions
3.9
11.0
32
84
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.7
10.8
303
2132
H25.1
ICD-10 Finland
Senile nuclear cataract
1.7
10.7
264
1794
H54.1
ICD-10 Finland
Severe visual impairment, binocular
111.4
10.4
11
*
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
111.4
10.4
11
*
3774A
ICD-9 Finland
Disorders of optic nerve and visual pathways, Other disorders of optic nerve
+∞
10.4
10
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
4.1
10.3
28
70
ZXA10
NOMESCO Finland
Bilateral
1.8
10.2
168
1015
CKC12
NOMESCO Finland
Photocoagulation of retina
2.9
9.6
46
166
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
7.3
9.6
22
31
M31.6
ICD-10 Finland
Other giant cell arteritis
17.8
9.4
14
8
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
9.2
211
1398
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.4
9.0
62
269
L03AX13
ATC
glatiramer acetate; parenteral
18.9
9.0
13
7
A10AC01
ATC
insulin (human); parenteral
2.2
8.7
73
345
B01AC04
ATC
clopidogrel; oral
1.8
8.7
158
977
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.9
8.7
115
644
A11CC03
ATC
alfacalcidol; systemic
3.5
8.7
29
84
WX892
NOMESCO Finland
Monitored bed care
2.2
8.7
72
339
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
7.8
8.7
19
25
H57.1
ICD-10 Finland
Ocular pain
2.9
8.6
40
143
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
8.5
137
818
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
6.8
8.4
20
30
H47.7
ICD-10 Finland
Disorder of visual pathways, unspecified
+∞
8.3
8
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.7
8.3
26
72
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
9.6
8.3
16
17
C08CA01
ATC
amlodipine; oral
1.6
8.3
324
2434
WX872
NOMESCO Finland
Intensive care
2.5
8.2
52
218
N03AX14
ATC
levetiracetam; systemic
3.5
8.1
28
83
A02BC02
ATC
pantoprazole; systemic
1.6
8.0
539
4549
A10AE04
ATC
insulin glargine; parenteral
2.0
8.0
90
478
R42
ICD-10 Finland
Dizziness and giddiness
1.6
7.9
196
1317
H53.8
ICD-10 Finland
Other visual disturbances
4.1
7.8
21
52
XCW12
NOMESCO Finland
Assessment of colour vision
45.4
7.7
9
*
H54.0
ICD-10 Finland
Blindness, binocular
45.4
7.7
9
*
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
7.7
184
1226
N03AX16
ATC
[U] pregabalin
1.6
7.6
189
1269
H3603, E103,
ICD-10 Finland
12.0
7.6
13
11
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
7.5
339
2611
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.1
7.5
72
360
C07AB07
ATC
bisoprolol; oral
1.5
7.4
410
3292
A28
ICPC
Limited function/disability NOS
1.7
7.4
163
1061
R20.2
ICD-10 Finland
Paraesthesia of skin
2.3
7.3
57
262
TK800
NOMESCO Finland
Hemodialysis
3.5
7.3
25
74
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.5
7.3
44
180
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
4.4
7.2
18
42
S01ED51
ATC
timolol, combinations; ophthalmic
2.0
7.2
75
386
ZXD05
NOMESCO Finland
Urgent procedure
1.6
7.2
229
1629
XCH00
NOMESCO Finland
Eye pressure measurement
2.3
7.2
52
231
C03CA01
ATC
furosemide; systemic
1.5
7.2
266
1959
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.3
7.2
26
80
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
20.2
7.1
10
5
I50.0
ICD-10 Finland
Congestive heart failure
2.0
7.1
75
388
C10AA05
ATC
atorvastatin; oral
1.5
7.0
353
2770
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.9
7.0
89
492
F01
ICPC
Eye pain
3.1
6.9
28
92
M05BA04
ATC
alendronic acid; oral
2.0
6.9
76
399
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
6.9
131
817
H40.0
ICD-10 Finland
Glaucoma suspect
2.0
6.9
75
392
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.2
6.9
61
295
205
Kela drug reimbursment
Chronic hypertension
1.6
6.9
223
1593
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
4.2
6.8
18
44
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
6.8
131
821
H43.1
ICD-10 Finland
Vitreous haemorrhage
3.1
6.8
27
88
H28.0*E10.3
ICD-10 Finland
Other specified diabetes mellitus - Diabetic cataract
40.4
6.8
8
*
ZXC40
NOMESCO Finland
Use of ultrasound
8.8
6.6
13
15
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.4
6.6
42
177
I10
ICD-10 Finland
Essential (primary) hypertension
1.5
6.5
499
4233
XA800
NOMESCO Finland
Neuropsychological investigation
2.6
6.4
37
148
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.8
6.4
95
552
H40.11
ICD-10 Finland
Low pressure glaucoma
3.2
6.4
25
81
R50.9
ICD-10 Finland
Fever, unspecified
1.7
6.4
119
740
N02BE01
ATC
paracetamol; systemic, rectal
1.8
6.3
694
6351
H3603, E113,
ICD-10 Finland
6.0
6.3
16
27
34099
ICD-8 Finland
Multiple sclerosis
+∞
6.3
6
*
H47
ICD-10 Finland
Other disorders of optic [2nd] nerve and visual pathways
+∞
6.3
6
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.1
6.2
61
308
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
3.2
6.2
24
77
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.5
6.2
37
151
ZXE20
NOMESCO Finland
More than three and less than five hours
1.7
6.2
114
706
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
3.5
6.2
21
62
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
4.2
6.1
16
39
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.8
6.0
95
562
R4110
NOMESCO Finland
Physiotherapy
1.5
6.0
217
1579
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.6
6.0
33
129

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
134
453
3.36
32.00
2.7
2.5
21.80
18.72
au/ml
—
10
37
39
44
9.27
31.80
1.2
1.1
36.00
44.86
mg/l
0.49
39
38
27
33
8.44
20.61
1.3
1.1
0.76
0.49
ratio
2.40
22
20
516
3763
2.07
20.41
11.1
7.5
1.21
1.21
mmol/l
0.18
452
3240
357
2307
2.00
19.65
2.7
2.2
201.93
238.33
u/l
0.33
338
2184
53
132
4.23
19.54
1.3
1.2
—
—
—
0
0
502
3681
2.00
18.84
9.3
6.3
2.01
1.90
e9/l
0.23
441
3224
495
3619
1.98
18.65
9.3
6.2
0.60
0.59
e9/l
0.45
432
3085
79
268
3.16
18.44
1.3
1.2
—
—
—
0
0
366
2431
1.94
18.18
9.4
6.1
—
—
—
0
0
494
3629
1.96
18.11
9.4
6.2
0.04
0.04
e9/l
0.04
430
3099
535
4041
2.00
18.06
12.5
9.7
4.41
4.15
e9/l
1.61
472
3513
558
4285
2.03
17.86
7.0
5.3
6.86
6.74
mmol/l
0.64
537
4079
467
3389
1.92
17.50
9.8
6.8
1.21
1.21
mmol/l
0.45
438
3117
127
585
2.39
16.37
3.7
2.8
9.53
10.90
g/l
4.49
122
539
392
2735
1.86
16.11
5.7
4.1
182.45
118.14
e6/l
0.25
289
1952
497
3736
1.89
16.10
9.6
6.4
0.22
0.19
e9/l
1.68
437
3247
357
2431
1.85
15.75
4.5
3.5
94.13
81.75
e6/l
0.11
284
1878
460
3411
1.83
15.17
9.9
6.4
25.77
26.94
%
1.29
440
3233
449
3316
1.82
14.89
6.8
5.2
35.00
35.34
g/l
0.61
425
3120
453
3359
1.82
14.78
10.0
6.5
8.80
8.99
%
0.72
430
3149
33
72
4.74
14.35
1.2
1.2
—
—
—
0
0
334
2278
1.81
14.26
6.1
4.3
7.40
7.40
ph
0.01
253
1637
450
3352
1.79
14.24
10.0
6.4
2.85
2.87
%
0.05
430
3137
182
1020
2.02
14.23
9.2
5.9
1.07
1.04
mmol/l
0.87
175
946
51
156
3.43
14.05
1.4
1.3
21.53
856.00
e6/l
0.60
43
121
318
2145
1.81
14.03
5.7
4.5
—
—
—
0
0
449
3353
1.78
13.98
10.1
6.4
0.64
0.68
%
0.55
429
3134
646
5405
2.06
13.97
11.4
8.5
82.85
79.19
u/l
0.85
614
5112
136
693
2.16
13.66
11.1
7.6
11.56
10.42
mmol/l
1.00
131
667
49
154
3.33
12.94
1.4
1.2
3.30
15.19
e6/l
1.14
37
116
30
66
4.69
12.92
1.2
1.1
—
—
—
0
0
406
2989
1.74
12.88
4.9
3.7
6.29
6.26
ph
0.24
219
1656
165
923
2.00
12.85
3.5
2.8
1.80
1.81
%
0.08
155
832
444
3354
1.74
12.82
9.8
6.3
58.95
57.77
%
1.21
430
3197
461
3521
1.74
12.78
23.4
16.1
1.36
1.28
inr
1.76
377
2953
291
1968
1.76
12.35
3.9
3.3
—
0.00
estimate
—
0
11
261
1715
1.78
12.21
3.5
2.8
5.22
5.18
e6/l
0.02
242
1562
196
1182
1.88
12.14
2.7
2.0
30.57
29.49
s
0.67
190
1150
168
963
1.95
12.13
1.5
1.3
374.55
470.78
titre
0.59
33
217
305
2101
1.74
12.07
4.1
3.4
0.31
0.48
e6/l
1.09
233
1563
493
3878
1.72
11.89
7.9
6.8
12.04
11.51
umol/l
0.27
477
3714
204
1274
1.81
11.18
4.0
3.4
0.80
0.82
mmol/l
1.22
194
1202
384
2869
1.66
10.88
5.3
4.1
33.62
69.05
ng/l
0.94
294
2178
126
677
2.02
10.87
2.6
3.1
65.37
66.58
g/l
1.01
118
626
141
790
1.96
10.80
6.4
3.6
1.52
1.88
mmol/l
0.46
126
676
473
3740
1.66
10.62
5.6
4.1
0.00
4.36
estimate
0.80
97
804
468
3705
1.64
10.32
5.6
4.1
0.00
0.00
estimate
-0.00
96
782
95
469
2.17
10.23
2.8
1.7
1.30
1.52
g/l
0.47
89
432
130
721
1.96
10.23
3.0
2.8
72.39
69.09
e9/l
0.57
91
546
560
4663
1.69
9.94
7.0
4.9
19.07
2601.23
e6/l
2.02
14
77
412
3180
1.62
9.91
2.9
2.5
78.78
77.98
nmol/l
0.22
382
2841
142
823
1.88
9.77
6.4
3.6
7.38
7.38
ph
0.50
100
477
472
3782
1.61
9.59
5.6
4.1
0.04
0.41
estimate
0.45
94
752
730
6621
2.33
9.54
27.6
17.5
23.93
25.35
mg/l
0.63
638
5524
13
6
21.99
9.37
1.2
1.0
6.74
7.19
mg/g
—
13
6
13
6
21.99
9.37
1.2
1.0
—
—
—
0
0
181
1153
1.74
9.06
4.1
2.6
20.40
22.47
%
1.47
174
1086
411
3221
1.57
8.90
3.9
3.1
131.74
136.51
ug/l
0.21
381
2990
103
554
1.99
8.80
2.6
2.7
—
—
—
0
0
89
454
2.08
8.79
6.5
3.4
24.00
24.19
mmol/l
0.21
89
448
199
1313
1.69
8.73
4.0
2.6
11.33
12.81
umol/l
2.29
189
1233
118
671
1.89
8.56
11.4
8.8
—
—
—
0
0
341
2578
1.57
8.53
4.0
3.5
2.36
2.36
mmol/l
0.01
320
2323
197
1309
1.67
8.37
3.8
3.0
1.38
0.96
e6/l
0.68
105
718
312
2324
1.57
8.26
3.1
2.6
62.46
94.81
u/l
0.46
290
2167
187
1233
1.68
8.16
4.1
2.6
2.24
2.30
g/l
0.83
178
1153
341
2602
1.55
8.05
4.2
3.4
6.86
7.47
mmol/l
1.78
298
2190
329
2506
1.54
7.75
4.3
3.5
73.43
50.95
mg/l
0.90
220
1628
272
1989
1.56
7.69
2.5
2.3
2.99
2.96
mg/l
0.08
247
1713
189
1267
1.65
7.69
1.3
1.3
37.17
36.87
iu/ml
0.01
47
396
160
1027
1.70
7.68
2.0
1.8
—
—
—
0
0
140
868
1.74
7.61
2.3
1.7
—
—
—
0
0
262
1904
1.56
7.60
3.7
2.9
350.60
349.96
umol/l
0.03
228
1651
25
72
3.55
7.59
1.6
1.3
—
—
—
0
0
394
3131
1.51
7.54
16.0
11.9
0.00
0.00
e9/l
0.38
311
2552
213
1477
1.61
7.54
3.5
3.1
543.81
532.18
mosm/kgh2o
0.36
189
1291
302
2269
1.54
7.52
3.8
3.3
—
—
—
0
0
146
919
1.72
7.52
8.7
8.2
7.42
7.41
ph
0.22
84
534
144
908
1.72
7.36
8.5
8.2
0.79
0.99
mmol/l
0.20
117
752
121
727
1.78
7.32
1.9
1.6
—
—
—
0
0
142
899
1.71
7.14
1.9
1.6
—
—
—
0
0
332
2566
1.51
7.14
4.9
4.2
18.80
9.20
mg/mmol
1.34
220
1614
145
924
1.70
7.12
8.6
8.1
12.59
11.93
kpa
0.78
138
892
145
924
1.70
7.12
8.6
8.1
4.99
5.12
kpa
0.84
138
891
411
3330
1.49
6.94
2.3
2.2
93.64
95.25
pmol/l
0.29
235
1730
38
149
2.63
6.87
1.4
1.1
—
—
—
0
0
736
6838
2.10
6.73
32.1
21.1
139.57
139.66
mmol/l
0.44
726
6697
80
433
1.94
6.71
9.3
10.9
16.04
15.71
%
0.43
74
418
70
363
2.02
6.63
2.3
2.0
1.48
1.52
g/l
0.12
60
333
736
6846
2.08
6.58
32.6
21.3
3.99
3.99
mmol/l
0.05
726
6693
46
203
2.34
6.50
5.6
2.6
65.38
59.15
%
1.22
46
196
34
130
2.69
6.46
1.4
1.4
131.83
166.01
au/ml
—
6
36
730
6778
2.00
6.45
22.9
15.8
—
—
—
0
0
294
2259
1.48
6.31
1.8
1.7
21.00
20.11
nmol/l
0.44
250
1906
58
287
2.10
6.23
1.4
1.8
8.46
7.39
iu/ml
0.10
12
75
85
483
1.85
6.15
1.5
1.5
—
—
—
0
0
22
68
3.30
6.04
2.0
2.6
900.14
821.71
mg
0.09
22
68
35
141
2.55
6.02
1.5
1.4
—
—
—
0
0
52
250
2.16
6.02
3.5
3.8
10.34
2.66
ratio
0.41
31
148
174
1209
1.56
5.96
4.3
3.2
3.67
1.96
e6/l
0.84
82
624
514
4430
1.46
5.85
4.4
3.4
53.67
51.17
u/l
0.25
487
4147
18
50
3.66
5.78
1.6
1.8
45.56
38.91
%
0.90
18
50
302
2363
1.45
5.78
4.7
3.3
43.22
32.73
u/l
0.62
290
2230
130
850
1.63
5.73
3.6
3.0
8.86
8.30
umol/l
0.08
110
755
189
1349
1.53
5.71
1.9
1.7
1176.92
1190.12
nmol/l
0.09
157
1019
689
6332
1.68
5.68
8.2
6.9
41.59
39.83
mmol/mol
4.13
653
5899
108
675
1.69
5.65
5.2
4.7
1.73
0.96
%
0.86
48
228
127
831
1.63
5.57
8.8
8.5
96.24
95.26
%
1.61
121
805
119
769
1.64
5.49
9.6
8.9
117.43
120.55
g/l
0.82
113
754
15
29
5.25
5.41
1.1
1.0
1874.67
1548.48
miu/ml
0.40
15
29
54
277
2.02
5.30
3.6
3.9
34.35
57.04
mg/l
0.88
47
238
54
277
2.02
5.30
3.6
3.9
122.98
74.92
mg/l
0.28
46
238
158
1102
1.54
5.27
2.7
2.1
—
—
—
0
0
744
7021
2.00
5.22
34.7
23.2
88.77
80.08
umol/l
3.46
734
6934
738
6949
1.93
5.16
17.6
12.7
27.45
25.62
u/l
1.05
718
6738
40
185
2.22
5.12
1.3
1.3
—
—
—
0
0
101
637
1.67
5.11
5.2
4.8
0.22
0.13
%
0.31
41
189
212
1588
1.46
4.98
1.9
1.7
1.66
1.34
mg/l
0.51
168
1235
25
94
2.71
4.95
2.8
2.5
0.98
1.22
g/24h
0.24
14
57
61
336
1.88
4.89
6.7
6.0
0.89
0.87
%
0.07
55
315
102
653
1.65
4.87
5.6
5.0
0.15
0.16
%
0.04
40
179
31
131
2.42
4.87
1.2
1.3
309.44
310.48
u/ml
0.01
25
69
28
113
2.53
4.84
1.3
1.7
0.58
0.76
g/l
0.51
21
91
585
5245
1.44
4.81
5.0
4.3
15.21
14.91
pmol/l
2.03
546
4758
23
84
2.79
4.81
1.5
1.3
—
—
—
0
0
333
2718
1.39
4.79
2.3
2.2
—
—
—
0
0
43
211
2.10
4.77
1.1
1.1
—
—
—
0
0
100
641
1.64
4.75
4.8
4.6
1.61
0.61
%
0.54
42
212
95
602
1.66
4.72
6.6
3.8
128.20
86.99
ng/l
1.66
82
528
273
2159
1.40
4.71
9.0
6.4
—
—
—
0
0
108
708
1.61
4.69
2.7
2.1
359.76
381.69
nmol/l
0.56
101
663
246
1914
1.41
4.65
4.0
3.2
0.00
0.04
—
6
52
189
1403
1.46
4.62
1.7
1.5
2.33
2.57
g/l
1.22
124
827
21
75
2.85
4.58
2.2
1.8
11.72
10.15
%
1.19
21
75
53
287
1.91
4.49
2.5
2.8
9.05
10.60
g/l
1.73
44
260
22
82
2.73
4.45
4.3
4.6
—
—
—
0
0
671
6218
1.52
4.31
6.3
5.4
1.98
1.96
mu/l
0.14
628
5671
197
1492
1.43
4.29
4.7
4.1
181.91
421.33
ng/l
2.09
163
1211
14
34
4.17
4.22
1.6
2.1
103.50
80.87
umol/l
—
8
23
63
369
1.77
4.18
6.6
5.7
1.41
1.53
%
0.76
57
350
103
692
1.56
4.04
3.1
2.5
34.86
33.98
u/l
0.09
90
573
600
5467
1.40
4.00
32.3
21.7
14.03
13.73
%
5.08
595
5403
92
605
1.59
3.95
5.0
3.8
1.22
1.23
mmol/l
0.15
85
525
36
178
2.07
3.95
2.6
2.9
33.85
32.11
umol/l
0.21
27
158
21
82
2.60
3.91
1.9
2.4
—
—
—
0
0
386
3298
1.33
3.87
3.2
2.8
—
—
estimate
—
0
0
262
2114
1.36
3.85
6.1
4.2
0.00
0.01
estimate
0.78
88
721
200
1545
1.39
3.85
6.4
4.9
—
—
—
0
0
19
71
2.72
3.84
1.1
1.2
—
—
—
0
0
288
2361
1.35
3.81
3.2
2.5
—
—
—
0
0
108
747
1.52
3.72
2.4
2.5
0.22
0.21
g/l
0.93
102
697
298
2464
1.34
3.70
3.8
3.3
2296.27
1438.07
ng/l
1.44
260
2125
158
1187
1.41
3.55
1.3
1.3
11.82
12.60
u/ml
0.05
60
438
331
2794
1.32
3.51
5.6
4.1
1.29
0.03
estimate
0.49
79
658
96
656
1.53
3.50
2.9
2.5
4.95
7.36
ug/l
1.66
84
589
20
81
2.51
3.48
2.0
1.6
—
—
—
0
0
222
1770
1.35
3.47
3.0
2.4
—
—
—
0
0
10
22
4.59
3.43
6.0
5.1
42.10
47.07
%
—
10
22
28
133
2.15
3.43
2.0
1.8
—
—
—
0
0
745
7139
1.75
3.42
40.7
26.6
248.33
245.53
e9/l
0.51
737
6995
745
7140
1.75
3.40
40.5
26.5
91.84
91.40
fl
1.76
739
7055
745
7141
1.74
3.38
40.5
26.5
30.43
30.39
pg
0.21
739
7055
745
7141
1.74
3.38
41.6
27.1
39.62
40.14
%
1.77
739
7050
745
7141
1.74
3.38
40.6
26.6
4.38
4.45
e12/l
3.44
734
6973
745
7141
1.74
3.38
40.7
26.6
7.13
6.80
e9/l
2.29
733
6976
745
7143
1.74
3.35
40.9
26.8
131.68
134.36
g/l
4.65
739
7058
98
682
1.50
3.29
2.8
2.2
0.07
0.02
estimate
0.28
14
134
15
54
2.81
3.27
1.3
1.1
101.00
101.09
pmol/l
0.00
15
54
31
157
2.01
3.23
3.3
3.7
—
—
—
0
0
78
519
1.56
3.21
4.8
3.8
7.40
7.42
ph
1.60
64
440
14
49
2.89
3.20
2.5
2.6
43.43
39.54
%
—
7
26
79
528
1.55
3.19
4.7
3.8
5.29
5.12
kpa
0.72
74
509
125
918
1.43
3.18
1.7
1.5
—
—
—
0
0
22
98
2.28
3.15
3.2
1.9
—
—
—
0
0
18
73
2.50
3.14
1.7
1.4
0.22
0.39
nmol/l
1.03
13
53
40
224
1.83
3.12
1.5
1.5
234.84
278.70
ug/g
0.64
19
133
39
221
1.80
2.95
6.8
8.1
1.99
1.35
mmol/l
0.76
33
197
30
157
1.95
2.88
7.7
9.4
12.80
11.37
mmol/l
0.66
25
143
30
157
1.95
2.88
7.7
9.4
104.28
105.24
mmol/l
0.32
25
143
7
13
5.42
2.87
1.0
1.1
—
—
—
0
0
19
83
2.32
2.86
1.4
1.3
—
—
—
0
0
23
112
2.09
2.69
4.8
2.7
—
—
—
0
0
690
6555
1.41
2.69
6.1
5.4
4.37
4.54
mmol/l
4.38
647
6066
335
2905
1.27
2.69
2.1
2.0
1.40
1.33
mmol/l
0.68
277
2400
68
458
1.53
2.68
1.7
1.7
—
—
—
0
0
8
19
4.24
2.68
1.0
1.6
—
—
—
0
0
67
452
1.53
2.63
4.5
2.7
1.19
1.17
%
0.05
67
452
46
284
1.66
2.61
5.5
3.9
24.36
24.86
mmol/l
0.63
40
266
44
269
1.67
2.59
4.1
3.6
1340.79
287.17
mg/l
0.61
28
114
16
68
2.38
2.57
2.1
1.3
34.54
29.48
u/l
—
10
57
699
6666
1.42
2.56
7.0
6.1
2.47
2.63
mmol/l
5.19
654
6135
113
848
1.39
2.56
2.1
2.3
145.65
131.50
ug/g
0.13
88
676
26
136
1.94
2.53
3.9
4.5
2.64
2.63
mmol/l
0.01
18
90
203
1668
1.29
2.49
6.5
4.3
1.02
1.02
kg/l
0.93
148
1125
683
6495
1.38
2.48
6.3
5.5
6.16
6.01
mmol/l
1.78
637
5921
193
1579
1.29
2.44
1.4
1.3
2.63
1.50
u/ml
0.56
55
405
685
6521
1.38
2.44
6.0
5.2
1.42
1.46
mmol/l
1.67
639
5988
23
117
1.99
2.42
2.0
1.7
—
—
—
0
0
72
503
1.47
2.41
7.3
7.6
24.29
24.49
mmol/l
0.16
67
481
32
183
1.78
2.39
1.8
1.8
—
—
—
0
0
659
6243
1.33
2.37
5.1
4.5
1.35
1.27
mmol/l
1.74
612
5685
12
47
2.58
2.28
1.1
1.9
—
—
—
0
0
20
99
2.05
2.27
1.5
1.3
—
—
—
0
0
25
135
1.88
2.24
1.9
1.5
—
—
—
0
0
84
614
1.41
2.23
3.6
3.3
249.72
216.85
ng/l
0.21
75
568
16
73
2.22
2.22
1.1
1.1
—
—
—
0
0
11
41
2.71
2.21
5.8
2.5
0.82
0.85
index
0.09
11
41
189
1561
1.28
2.21
3.1
3.1
2.45
2.46
mmol/l
0.29
172
1397
7
19
3.71
2.15
1.7
1.8
—
—
—
0
0
6
14
4.31
2.15
1.0
1.0
—
—
—
0
0
55
373
1.51
2.14
5.5
3.8
—
—
—
0
0
8
25
3.22
2.10
2.3
2.6
0.53
0.59
mmol/l
—
8
25
52
351
1.52
2.08
1.6
1.3
—
—
—
0
0
10
37
2.72
2.07
1.1
1.1
—
—
—
0
0
86
640
1.39
2.07
1.8
1.5
—
—
—
0
0
28
164
1.73
1.97
2.0
1.3
24.34
8.82
u/l
1.23
19
126
5
11
4.57
1.94
15.0
11.7
4.70
5.55
mmol/l
—
5
11
16
78
2.07
1.92
2.4
2.7
—
—
—
0
0
30
182
1.67
1.87
3.9
3.1
3.00
2.29
index
0.23
18
100
25
144
1.76
1.87
2.1
2.1
1760.54
6088.20
u/l
—
7
48
86
653
1.36
1.85
1.5
1.4
—
—
—
0
0
114
905
1.30
1.81
3.0
3.4
4.63
5.00
e9/l
0.31
94
782
21
116
1.83
1.80
1.0
1.1
—
—
—
0
0
45
305
1.50
1.79
1.3
1.5
0.40
0.33
mg/l
0.22
18
132
51
360
1.45
1.68
3.6
2.3
0.00
0.01
estimate
0.50
12
105
15
76
1.99
1.65
1.2
1.3
—
—
—
0
0
47
330
1.45
1.60
1.3
1.3
—
—
—
0
0
15
77
1.97
1.60
1.4
1.4
21.33
28.70
ng/l
0.62
15
77
8
32
2.51
1.60
1.6
1.9
40.20
40.83
g/l
—
8
32
6
20
3.01
1.58
7.0
4.2
—
—
—
0
0
7
26
2.71
1.58
1.4
3.6
4.71
6.11
ug/l
—
7
26
18
100
1.82
1.54
1.3
1.1
1.67
8.05
u/ml
—
9
42
104
835
1.28
1.53
1.3
1.3
—
—
—
0
0
27
171
1.60
1.47
1.3
1.2
—
—
—
0
0
72
554
1.33
1.45
1.2
1.2
—
—
—
0
0
11
52
2.13
1.45
1.1
1.2
—
—
—
0
0
5
16
3.14
1.44
1.0
1.0
—
—
—
0
0
6
22
2.74
1.43
1.7
1.3
—
—
—
0
0
226
1988
1.19
1.42
4.6
3.6
3.20
0.05
estimate
0.49
79
632
183
1580
1.21
1.41
1.9
1.8
402.80
23489345.79
pmol/l
1.25
147
1307
15
81
1.87
1.41
1.0
1.2
—
—
—
0
0
14
74
1.91
1.39
1.1
1.1
—
—
—
0
0
10
47
2.14
1.34
1.2
1.0
—
—
—
0
0
26
169
1.56
1.30
1.8
1.4
—
—
—
0
0
22
138
1.61
1.27
1.5
1.6
—
—
—
0
0
26
171
1.54
1.24
2.3
1.8
6.96
3.78
iu/l
—
5
59
26
171
1.54
1.24
1.8
1.4
—
—
—
0
0
55
418
1.34
1.23
1.3
1.2
167.84
132.86
u/ml
0.27
18
162
28
188
1.51
1.23
2.3
2.1
129.63
128.30
g/l
0.08
19
146
29
418
0.68
1.22
2.0
1.8
3.53
3.49
mmol/l
0.06
22
306
10
49
2.05
1.22
1.1
1.1
—
—
—
0
0
26
172
1.53
1.22
1.8
1.4
—
—
—
0
0
5
19
2.64
1.21
2.4
1.2
—
—
—
0
0
25
164
1.54
1.21
1.9
1.4
—
—
—
0
0
61
473
1.31
1.20
1.3
1.3
—
—
—
0
0
19
117
1.64
1.19
3.0
3.1
4.51
4.42
e9/l
0.05
19
117
17
103
1.66
1.13
1.5
1.6
—
—
—
0
0
17
103
1.66
1.13
1.5
1.6
—
—
—
0
0
17
103
1.66
1.13
1.5
1.6
—
—
—
0
0
17
103
1.66
1.13
1.5
1.6
—
—
—
0
0
24
159
1.53
1.13
1.2
1.4
47.89
57.79
mmol/l
0.54
18
136
26
178
1.48
1.06
1.1
1.1
—
—
—
0
0
19
121
1.58
1.06
1.0
1.1
—
—
—
0
0
73
593
1.25
1.03
2.8
2.3
10.21
12.90
nmol/l
2.10
62
521
7
34
2.07
1.03
1.0
1.1
—
—
—
0
0
278
2544
1.14
1.02
5.4
5.9
2.29
3.04
ug/l
0.95
248
2269
85
705
1.23
1.00
6.6
4.5
7.37
7.36
ph
0.17
65
512
23
156
1.49
0.99
3.1
2.9
60.26
58.36
%
0.20
23
156
49
381
1.30
0.98
2.3
2.4
—
—
—
0
0
98
828
1.21
0.97
3.4
4.4
5.25
25.98
ug/l
1.37
78
695
39
295
1.34
0.94
1.1
1.1
—
—
—
0
0
110
943
1.19
0.94
1.4
1.3
—
—
—
0
0
6
29
2.08
0.89
31.3
35.4
87.83
122.09
ug/l
—
6
23
16
103
1.56
0.88
3.4
2.4
32.06
32.69
pg
0.19
16
103
69
569
1.23
0.88
5.4
4.0
—
—
—
0
0
13
80
1.64
0.85
1.5
1.6
58.43
62.66
%
—
7
55
6
31
1.94
0.84
1.2
1.1
211.00
181.02
iu/ml
—
6
31
24
171
1.42
0.84
1.9
1.4
—
—
—
0
0
26
190
1.38
0.80
2.7
2.5
99.91
95.37
ug/min
0.04
17
113
11
66
1.68
0.79
1.2
1.3
—
—
—
0
0
8
48
1.67
0.79
2.6
1.8
123.40
89.03
ng/l
—
8
48
27
200
1.36
0.77
4.6
5.3
—
—
—
0
0
6
34
1.77
0.76
2.3
1.8
23.00
53.54
ug/l
—
6
34
5
25
2.01
0.72
1.0
1.5
—
—
—
0
0
7
39
1.80
0.72
1.0
1.2
167.57
144.92
nmol/l
—
7
39
17
117
1.46
0.72
2.5
2.7
—
—
—
0
0
7
40
1.76
0.71
1.6
1.8
—
—
—
0
0
55
458
1.22
0.67
1.5
1.2
345.82
280.27
u/ml
0.16
50
422
14
94
1.50
0.67
1.2
1.7
—
—
—
0
0
5
28
1.79
0.66
1.4
1.2
6.06
6.77
mmol/l
—
5
28
42
341
1.24
0.65
2.6
1.9
—
—
—
0
0
37
456
0.80
0.62
1.4
1.4
—
—
—
0
0
14
96
1.47
0.61
1.5
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
22.69
—
0
13
11
72
1.54
0.59
2.2
1.8
—
—
—
0
0
11
73
1.51
0.56
1.5
1.2
—
—
—
0
0
11
73
1.51
0.56
1.3
1.2
—
—
—
0
0
8
122
0.65
0.55
1.4
1.6
—
—
—
0
0
6
38
1.58
0.54
1.0
1.3
104.47
178.21
pmol/l
—
6
38
63
545
1.17
0.54
3.1
2.7
6.23
6.07
ph
0.59
48
385
27
214
1.27
0.53
1.4
1.4
36.35
26.86
iu/l
0.54
21
180
6
40
1.50
0.51
1.5
1.4
73.83
82.83
umol/l
—
6
40
162
1497
1.10
0.51
3.4
3.3
0.76
0.79
ug/l
0.18
111
1012
11
75
1.47
0.51
1.5
2.4
—
—
—
0
0
11
75
1.47
0.51
2.3
2.1
—
—
—
0
0
16
119
1.35
0.48
1.3
1.6
26.24
31.53
g/l
0.78
11
107
13
93
1.40
0.48
1.3
1.5
—
—
—
0
0
14
102
1.38
0.47
1.1
1.1
—
16.72
—
0
18
20
156
1.29
0.45
4.6
4.0
29.39
32.21
mg/l
0.13
13
106
8
56
1.43
0.42
2.4
2.8
7.53
8.47
mmol/l
—
8
56
5
32
1.57
0.42
1.2
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
5.3
—
8.23
—
0
15
0
15
0.00
0.41
0.0
1.1
—
0.77
—
0
7
0
17
0.00
0.40
0.0
1.0
—
4.89
—
0
11
12
88
1.37
0.40
1.2
1.2
—
98.12
—
0
6
0
18
0.00
0.40
0.0
2.2
—
—
—
0
0
27
225
1.21
0.37
4.0
4.1
3.73
3.94
mmol/l
1.78
27
219
33
281
1.18
0.37
3.8
4.0
1.26
1.36
mmol/l
0.24
33
272
12
90
1.34
0.36
1.2
1.4
35540.00
119089.73
e6/l
—
5
44
12
90
1.34
0.36
1.1
1.1
—
—
—
0
0
12
91
1.32
0.34
1.1
1.1
—
—
—
0
0
7
55
1.28
0.30
2.6
2.9
14.93
16.68
%
—
7
55
37
326
1.14
0.29
2.5
3.6
36.83
4490.63
u/ml
0.83
30
280
13
103
1.27
0.28
1.3
1.4
1031.75
1624.55
e6/l
—
8
64
21
244
0.86
0.24
1.8
1.7
—
—
—
0
0
66
712
0.92
0.24
1.7
1.6
—
—
—
0
0
34
304
1.12
0.23
3.1
3.0
—
—
—
0
0
5
41
1.22
0.22
3.4
2.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
10.80
—
0
5
0
11
0.00
0.21
0.0
1.0
—
17.67
—
0
11
0
11
0.00
0.21
0.0
1.5
—
66.64
—
0
11
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
16.71
—
0
7
0
13
0.00
0.21
0.0
1.1
—
60.06
—
0
13
22
193
1.14
0.19
1.5
1.2
—
—
—
0
0
22
197
1.12
0.15
1.6
1.7
5355.92
15013.47
e6/l
1.54
12
144
9
79
1.14
0.15
1.1
1.2
—
—
nmol/l
—
0
0
9
81
1.11
0.15
1.3
1.1
—
—
—
0
0
236
2414
0.97
0.14
3.8
3.4
—
—
—
0
0
12
105
1.15
0.11
3.3
2.9
1.22
1.19
mmol/l
0.49
12
105
6
55
1.09
0.09
1.3
1.2
488.83
381.60
nmol/l
—
6
47
18
165
1.09
0.08
1.2
1.4
—
—
—
0
0
6
57
1.05
0.08
1.0
1.2
—
—
—
0
0
6
58
1.03
0.08
1.0
1.1
—
2.02
—
0
10
11
98
1.12
0.07
1.0
1.3
—
—
—
0
0
19
176
1.08
0.07
1.2
1.2
0.78
0.91
g/l
1.92
19
176
12
108
1.11
0.07
3.3
2.9
103.50
105.09
mmol/l
0.44
12
108
12
108
1.11
0.07
3.3
2.9
4.27
4.08
mmol/l
0.93
12
108
16
171
0.93
0.05
1.3
1.2
—
—
—
0
0
27
259
1.04
0.04
1.6
1.6
4.12
11.07
u/ml
—
5
50
191
1895
1.01
0.03
1.4
1.4
—
—
—
0
0
22
212
1.04
0.02
15.6
10.8
—
—
—
0
0
101
1001
1.01
0.01
1.3
1.2
—
—
—
0
0
53
538
0.98
0.01
1.4
1.5
—
—
—
0
0
17
164
1.04
0.00
1.1
1.2
1.46
1.57
g/l
1.04
17
164
17
164
1.04
0.00
1.5
1.6
1207.88
972.84
mu/l
0.47
12
133
0
9
0.00
0.00
0.0
1.2
—
0.46
—
0
9
0
6
0.00
0.00
0.0
2.2
—
0.53
—
0
6
8
87
0.92
0.00
1.3
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
9
90
1.00
0.00
1.2
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
41.63
—
0
8
0
8
0.00
-0.00
0.0
1.3
—
1.95
—
0
8
0
5
0.00
-0.00
0.0
3.0
—
188.20
—
0
5
6
66
0.91
-0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
30.86
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.06
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
82
0.98
-0.00
1.5
1.7
—
—
—
0
0
8
80
1.00
-0.00
1.6
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
6.1
—
0.16
—
0
7

Mortality – FinRegistry

Association

Association between endpoint H7_OPTNERVNAS and mortality.

Females

Parameter HR [95% CI] p-value
H7_OPTNERVNAS 1.359 [1.17, 1.58] < 0.001
Birth year 0.993 [0.98, 1.0] 0.108

During the follow-up period (1.1.1998 — 31.12.2019), 489 out of 1941 females with H7_OPTNERVNAS died.

Males

Parameter HR [95% CI] p-value
H7_OPTNERVNAS 1.46 [1.26, 1.69] < 0.001
Birth year 0.989 [0.98, 1.0] 0.016

During the follow-up period (1.1.1998 — 31.12.2019), 567 out of 1962 males with H7_OPTNERVNAS died.

Mortality risk

Mortality risk for people of age

years, who have H7_OPTNERVNAS.

N-year risk Females Males
1 0.108% 0.271%
5 0.801% 2.134%
10 2.05% 4.791%
15 3.769% 8.823%
20 6.255% 14.356%

Relationships between endpoints

Index endpoint: H7_OPTNERVNAS – Disorders of optic nerve, not elsewhere classified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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