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This is a non-core endpoint: only basic statistics are computed.

Drug-induced fever

DRUGADVERS_FEVER

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 R50.2#

1 out of 7 registries used, show all original rules.

70

4. Check minimum number of events

None

70

5. Include endpoints

None

70

6. Filter based on genotype QC (FinnGen only)

64

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 64 37 27
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 62.61 63.28 61.69

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
66
Matched controls
660
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R50.2
ICD-10 Finland
Drug-induced fever
+∞
94.8
66
*
R50.9
ICD-10 Finland
Fever, unspecified
9.4
19.1
36
75
A49.9
ICD-10 Finland
Bacterial infection, unspecified
6.6
10.1
20
41
WZC00
NOMESCO Finland
Treatment plan or consultation
4.3
7.8
40
175
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.7
7.7
48
240

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
45
167
6.33
12.10
7.2
4.8
—
—
—
0
0
53
333
4.00
5.18
10.7
5.8
0.57
0.58
e9/l
0.18
48
289
41
221
3.26
5.14
9.0
5.6
—
—
—
0
0
53
335
3.96
5.08
10.7
5.8
0.03
0.04
e9/l
1.44
48
289
36
181
3.18
5.06
4.6
3.0
0.14
0.44
e6/l
1.67
29
134
39
209
3.12
4.85
4.9
3.1
15.08
23.46
e6/l
0.45
33
162
56
373
4.31
4.83
22.9
10.9
3.87
4.02
e9/l
0.23
49
323
53
343
3.77
4.72
11.0
5.9
1.94
1.85
e9/l
0.29
48
305
49
308
3.29
4.47
9.9
5.7
56.87
57.38
%
0.10
49
294
29
141
2.88
4.16
7.3
5.5
—
—
—
0
0
35
193
2.73
3.89
4.0
3.1
—
—
—
0
0
40
238
2.73
3.80
5.6
3.9
15.27
43.79
e6/l
0.87
34
168
33
179
2.69
3.76
4.8
3.0
—
—
estimate
—
0
0
35
201
2.58
3.49
5.9
5.1
7.41
7.39
ph
0.62
25
145
15
58
3.05
3.13
5.8
3.7
1.25
0.74
%
—
8
19
14
52
3.15
3.12
5.5
3.5
0.71
1.07
%
—
7
14
43
283
2.49
3.07
3.4
3.2
—
—
estimate
—
0
0
35
211
2.40
3.03
3.7
2.9
53.97
78.34
u/l
0.57
35
195
5
5
10.66
3.03
1.0
1.2
—
—
—
0
0
14
53
3.08
3.02
6.0
3.8
0.29
0.21
%
—
7
14
6
9
7.19
2.93
3.8
1.7
3.48
5.51
e9/l
—
6
9
55
414
2.97
2.87
7.5
4.6
—
47.56
—
0
9
7
14
5.45
2.81
4.0
6.2
7.42
7.44
ph
—
7
14
14
56
2.90
2.74
5.8
3.9
0.00
0.07
%
—
7
15
59
475
3.28
2.73
18.2
8.9
85.81
84.84
u/l
0.07
59
447
46
325
2.37
2.63
11.9
10.3
1.22
1.21
mmol/l
0.40
41
279
6
12
5.38
2.46
2.2
3.5
16.15
14.92
%
—
6
12
18
87
2.47
2.46
11.2
9.1
103.72
104.25
mmol/l
0.25
18
87
11
40
3.09
2.41
8.8
13.0
95.47
93.28
%
0.92
11
40
5
8
6.65
2.41
1.8
2.8
90.84
89.34
%
—
5
8
16
75
2.50
2.32
9.6
16.6
7.46
7.43
ph
—
10
47
10
38
2.92
2.11
11.8
6.2
1.19
1.21
mmol/l
—
10
32
6
15
4.29
2.09
4.5
1.5
51.33
61.23
%
—
6
15
14
66
2.42
1.99
1.7
1.6
—
—
—
0
0
17
89
2.23
1.92
2.0
2.9
—
—
—
0
0
15
75
2.29
1.88
1.6
1.2
—
—
—
0
0
5
12
4.41
1.86
3.2
2.6
—
—
—
0
0
5
12
4.41
1.86
3.8
4.8
8.58
8.17
kpa
—
5
12
5
12
4.41
1.86
3.8
4.8
4.42
4.80
kpa
—
5
12
11
48
2.55
1.82
6.7
10.6
7.47
9.23
mmol/l
0.56
11
48
6
18
3.56
1.79
1.0
1.3
1.18
1.27
g/l
—
6
18
6
18
3.56
1.79
1.0
1.3
0.23
0.26
g/l
—
6
18
10
40
2.76
1.75
9.4
3.2
—
—
—
0
0
13
63
2.32
1.74
1.5
1.6
—
—
—
0
0
10
43
2.56
1.68
6.7
15.8
—
—
—
0
0
5
14
3.77
1.64
3.0
1.6
—
—
—
0
0
12
58
2.31
1.61
9.9
10.6
—
—
—
0
0
15
80
2.13
1.61
1.5
1.7
—
—
—
0
0
52
424
2.07
1.60
6.4
4.4
—
—
—
0
0
51
579
0.48
1.56
5.3
5.2
1.34
1.46
mmol/l
1.46
46
532
5
15
3.51
1.55
4.4
2.6
—
—
—
0
0
6
21
3.04
1.54
1.3
1.5
—
—
—
0
0
5
16
3.29
1.46
1.0
1.3
—
—
—
0
0
9
41
2.38
1.44
10.6
12.6
1.32
1.35
%
—
9
41
9
41
2.38
1.44
10.6
12.6
0.67
0.68
%
—
9
41
11
54
2.24
1.42
9.4
9.2
25.23
24.99
mmol/l
0.07
11
54
18
108
1.92
1.41
2.0
2.4
11.56
13.32
umol/l
0.36
18
98
5
17
3.09
1.38
3.4
1.4
—
—
—
0
0
21
135
1.81
1.33
6.3
3.3
314.37
76.54
ng/l
0.58
16
102
5
18
2.92
1.31
3.4
2.4
—
—
—
0
0
10
49
2.23
1.30
3.4
3.6
4.61
5.07
kpa
—
10
49
28
198
1.72
1.28
2.9
2.6
—
—
—
0
0
27
189
1.73
1.28
5.2
2.1
144.26
142.86
u/l
0.01
27
180
6
25
2.54
1.27
1.3
1.4
—
—
—
0
0
5
20
2.62
1.17
3.6
2.0
—
—
—
0
0
7
31
2.40
1.14
3.3
4.3
8.97
9.05
kpa
—
7
31
38
299
1.64
1.12
22.3
11.8
0.00
0.00
e9/l
0.50
27
238
5
21
2.49
1.11
3.6
2.0
—
—
—
0
0
5
21
2.49
1.11
3.6
2.0
—
—
—
0
0
5
21
2.49
1.11
3.6
2.0
—
—
—
0
0
42
342
1.63
1.05
5.8
4.0
118.92
0.00
estimate
0.47
12
70
5
22
2.37
1.05
3.6
1.9
—
—
—
0
0
7
35
2.12
1.03
7.9
2.6
0.53
0.73
%
—
7
35
17
111
1.72
1.00
1.8
1.6
—
—
—
0
0
49
548
0.59
0.97
4.6
4.4
1.43
1.25
mmol/l
1.13
44
500
6
27
2.34
0.96
1.2
1.0
—
—
—
0
0
15
97
1.71
0.91
1.8
1.6
—
—
—
0
0
8
44
1.93
0.90
6.3
3.5
25.80
23.83
mmol/l
—
8
44
16
106
1.67
0.89
2.0
2.3
2.28
2.32
g/l
0.09
16
98
33
262
1.52
0.87
6.0
3.9
0.00
0.00
estimate
—
10
58
6
31
2.03
0.87
4.0
3.8
—
—
—
0
0
34
272
1.52
0.86
5.1
3.6
6.52
6.23
ph
0.65
22
149
8
47
1.80
0.84
5.3
3.7
—
—
—
0
0
41
343
1.52
0.83
5.9
4.0
0.00
0.00
estimate
-0.00
11
66
18
128
1.56
0.76
1.8
1.9
—
—
—
0
0
5
24
2.17
0.76
1.6
2.2
23.62
25.84
mmol/l
—
5
24
5
26
2.00
0.72
3.4
6.6
1.18
1.27
mmol/l
—
5
26
40
339
1.46
0.72
6.0
4.0
0.00
0.00
estimate
-0.00
11
66
19
139
1.52
0.71
7.1
1.4
4.03
2.14
g/l
0.40
12
81
16
216
0.66
0.69
3.8
3.3
—
—
—
0
0
14
98
1.54
0.63
2.7
2.3
22.93
22.61
%
0.02
14
91
30
246
1.40
0.62
5.3
3.5
23.67
27.99
ng/l
0.30
21
161
8
54
1.55
0.60
1.6
1.4
—
—
—
0
0
6
35
1.78
0.59
9.2
2.6
1.58
1.51
%
—
6
35
25
201
1.39
0.57
12.6
6.6
—
—
—
0
0
6
40
1.55
0.53
2.0
3.7
4.30
4.34
pmol/l
—
6
35
7
50
1.45
0.47
2.7
2.0
—
0.00
estimate
—
0
10
12
158
0.71
0.43
1.1
1.3
—
1.66
—
0
39
0
15
0.00
0.42
0.0
1.1
—
0.24
—
0
6
0
18
0.00
0.40
0.0
4.3
—
—
—
0
0
9
69
1.35
0.39
1.6
1.6
—
—
—
0
0
22
187
1.26
0.32
7.7
4.2
0.00
0.00
estimate
—
8
62
7
55
1.30
0.31
1.0
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
3.91
—
0
10
0
10
0.00
0.21
0.0
2.3
—
109.90
—
0
10
0
10
0.00
0.21
0.0
2.3
—
1.20
—
0
10
0
14
0.00
0.20
0.0
1.1
—
2.02
—
0
5
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
7
58
1.23
0.19
1.7
1.4
—
—
—
0
0
7
59
1.21
0.19
1.3
1.7
—
—
—
0
0
22
197
1.18
0.18
4.8
3.4
0.00
0.00
estimate
—
9
58
9
80
1.14
0.16
1.1
1.2
—
—
—
0
0
21
192
1.14
0.13
2.3
3.3
68.92
103.25
mg/l
0.29
14
119
6
54
1.12
0.09
1.2
1.2
—
—
—
0
0
17
184
0.90
0.08
1.3
1.3
—
—
—
0
0
6
72
0.82
0.08
1.2
1.3
—
—
—
0
0
21
197
1.10
0.07
2.7
3.8
6.44
10.36
mg/mmol
0.42
15
117
25
256
0.96
0.00
2.8
2.0
99.85
95.46
pmol/l
0.24
19
121
24
243
0.98
0.00
2.6
2.1
—
—
—
0
0
21
215
0.97
0.00
4.1
3.4
—
—
—
0
0
12
115
1.05
0.00
1.4
1.3
44.57
8.29
u/ml
—
7
43
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
182.16
—
0
5
0
5
0.00
0.00
0.0
1.0
—
174.60
—
0
5
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
15.2
—
16.02
—
0
5
0
5
0.00
0.00
0.0
1.4
—
0.90
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
50
1.00
-0.00
1.4
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
59
0.84
-0.00
8.6
3.5
7.39
7.34
ph
—
5
38
61
607
1.07
-0.00
30.8
14.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
12.7
—
7.50
—
0
6

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: DRUGADVERS_FEVER – Drug-induced fever

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).