No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
87 |
4. Check minimum number of eventsNone |
87 |
5. Include endpoints |
100 |
6. Filter based on genotype QC (FinnGen only) |
89 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E20-E35
- Name in latin
- Dysfunctio polyglandularis (endocrina)
Similar endpoints
↥List of similar endpoints to
Polyglandular dysfunction
based on the number of shared cases.
Similar with more cases:
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 523 | 320 | 196 |
| Only index persons | 419 | 270 | 149 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 38.73 | 38.37 | 38.89 |
| Only index persons | 35.72 | 35.52 | 36.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 89 | 59 | 30 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | 35.18 | 38.33 | 28.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 90
- Matched controls
- 900
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02AA02
ATC
fludrocortisone; oral
+∞
37.1
33
*
H02AB09
ATC
hydrocortisone; systemic
123.2
36.2
37
5
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
34.6
31
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
16.2
32.4
33
31
A10AE05
ATC
insulin detemir; parenteral
16.8
30.8
30
26
E31.00
ICD-10 Finland
APECED syndrome
+∞
28.7
26
*
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
+∞
28.7
26
*
H03AA01
ATC
levothyroxine sodium; systemic
10.0
27.9
54
117
T89
ICPC
Diabetes insulin dependent
13.8
26.5
29
30
A11CC03
ATC
alfacalcidol; systemic
56.9
24.4
28
7
106
Kela drug reimbursment
Hypoparathyroidism
+∞
22.9
21
*
A10AE04
ATC
insulin glargine; parenteral
9.3
22.0
34
55
A12AA04
ATC
calcium carbonate; oral
101.4
21.9
23
*
A10AB05
ATC
insulin aspart; parenteral
9.8
21.5
31
46
103
Kela drug reimbursment
Diabetes, insulin-treated
7.5
20.8
49
124
215
Kela drug reimbursment
Diabetes, non-insulin-treated
7.2
19.8
47
119
E31.08
ICD-10 Finland
Autoimmune polyglandular failure
+∞
18.3
17
*
E31.9
ICD-10 Finland
Polyglandular dysfunction, unspecified
+∞
18.3
17
*
A10AC01
ATC
insulin (human); parenteral
8.3
16.5
26
42
A11CC02
ATC
dihydrotachysterol; oral
+∞
15.0
14
*
E83.51
ICD-10 Finland
Hypocalcemia
177.7
14.9
15
*
SPAT1262
SPAT
Handing over of treatment supplies
6.0
13.4
30
69
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.9
12.5
44
148
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
35.5
12.1
15
5
A10AB04
ATC
insulin lispro; parenteral
12.7
11.8
21
21
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
+∞
11.7
11
*
E31.1
ICD-10 Finland
Polyglandular hyperfunction
+∞
11.7
11
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
40.9
11.6
14
*
WZC00
NOMESCO Finland
Treatment plan or consultation
4.3
10.7
55
239
E31.8
ICD-10 Finland
Other polyglandular dysfunction
+∞
10.6
10
*
2581B
ICD-9 Finland
Polyglandular dysfunction and related disorders, Other combinations of endocrine dysfunction[AUTOIMMUNE-POLYENDOCRINOPATHY-CANDIDOSIS-ECTOD DYST]
+∞
10.6
10
*
A12AA06
ATC
calcium lactate gluconate; oral
+∞
10.6
10
*
25810
ICD-8 Finland
Polyglandular dysfunction and other diseases of endocrine glands, Polyglandular dysfunction
+∞
10.6
10
*
XCK10
NOMESCO Finland
Photography of fundus of eye
6.1
10.4
21
43
121
Kela drug reimbursment
Severe hypofunction of sexual glands
23.3
10.2
14
7
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
30.0
10.1
13
5
A01AB09
ATC
miconazole; local oral
6.0
9.9
20
41
H04AA01
ATC
glucagon; nasal, parenteral
11.5
9.8
18
19
A07AA02
ATC
nystatin; oral
9.6
9.8
20
26
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
9.2
9.6
20
27
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
16.1
9.6
15
11
E31.0
ICD-10 Finland
Autoimmune polyglandular failure
+∞
9.5
9
*
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
9.5
9
*
25510
ICD-8 Finland
Diseases of adrenal glands, Adrenal cortical hypofunction
+∞
9.5
9
*
2581A
ICD-9 Finland
Polyglandular dysfunction and related disorders, Other combinations of endocrine dysfunction[SYNDROMA SCHMIDT]
+∞
9.5
9
*
104
Kela drug reimbursment
Thyroid insufficiency
8.2
9.4
21
32
A10AB01
ATC
insulin (human); parenteral
9.3
9.2
19
25
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
13.6
9.0
15
13
107
Kela drug reimbursment
Pernicious anaemia
55.6
8.9
10
*
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
+∞
8.5
8
*
E27.2
ICD-10 Finland
Addisonian crisis
+∞
8.5
8
*
E31.01
ICD-10 Finland
Schmidt's syndrome
+∞
8.5
8
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
5.2
8.4
20
47
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.6
8.4
46
201
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
9.3
8.3
17
22
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
19.5
8.3
12
7
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
37.0
8.3
10
*
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
37.0
8.3
10
*
E83.50
ICD-10 Finland
Hypercalcemia
37.0
8.3
10
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
4.5
8.2
24
67
J02AB02
ATC
ketoconazole; oral
24.7
8.2
11
5
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.1
8.2
20
48
C03CA01
ATC
furosemide; systemic
3.8
8.2
34
123
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.8
8.1
35
130
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
9.5
8.0
16
20
B37.08
ICD-10 Finland
Other candidal stomatitis
49.4
7.9
9
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.9
7.8
30
103
B03BA03
ATC
hydroxocobalamin; parenteral
12.4
7.6
13
12
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
87.0
7.5
8
*
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
87.0
7.5
8
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.2
7.5
24
72
SFA40
NOMESCO Finland
Restoration involving the entire crown of the tooth
3.9
7.5
28
94
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
4.5
7.4
21
57
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
7.4
7
*
E20.8
ICD-10 Finland
Other hypoparathyroidism
+∞
7.4
7
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
+∞
7.4
7
*
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
22.2
7.3
10
5
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
32.9
7.3
9
*
WX002
NOMESCO Finland
Sedation and analgesia
4.1
7.2
24
74
E03.89
ICD-10 Finland
Other specified hypothyroidism
9.5
7.1
14
17
A01AB04
ATC
amphotericin B; local oral
9.5
7.1
14
17
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
3.2
6.9
45
213
J01MA12
ATC
levofloxacin; systemic
3.8
6.9
26
87
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.2
6.9
51
260
SBA00
NOMESCO Finland
Microbiological examinations
18.5
6.9
10
6
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.7
6.9
28
99
A10AE06
ATC
insulin degludec; parenteral
7.9
6.9
15
22
Z01.8
ICD-10 Finland
Other specified special examinations
3.5
6.8
31
118
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.4
6.6
31
120
E87.6
ICD-10 Finland
Hypokalaemia
10.4
6.5
12
13
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.6
6.5
17
43
A09AA02
ATC
multienzymes (lipase, protease etc.); oral
12.3
6.5
11
10
WX882
NOMESCO Finland
High dependency care
19.7
6.4
9
5
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
6.5
6.4
16
29
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
28.9
6.3
8
*
K29.4
ICD-10 Finland
Chronic atrophic gastritis
28.9
6.3
8
*
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
28.9
6.3
8
*
25219
ICD-8 Finland
Diseases of parathyroid gland, Hypoparathyreoidismus alius sive NUD
+∞
6.3
6
*
H01AC01
ATC
somatropin; parenteral
+∞
6.3
6
*
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
+∞
6.3
6
*
XF400
NOMESCO Finland
ECG with 12 standard connections
3.9
6.2
21
65
Z31.5
ICD-10 Finland
Genetic counselling
6.7
6.2
15
26
H3600, E103,
ICD-10 Finland
16.4
6.0
9
6
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
49
89
10.89
29.76
15.7
7.3
1.20
1.10
mmol/l
1.17
49
81
30
45
9.50
20.58
9.6
10.9
26.58
24.96
mmol/l
0.75
30
45
48
121
7.36
20.44
10.7
4.2
0.77
0.81
mmol/l
1.55
48
116
29
48
8.44
18.16
18.5
3.1
1.21
1.23
mmol/l
0.57
29
41
74
344
7.48
14.72
38.2
9.6
1.17
1.21
mmol/l
2.11
68
299
50
178
5.07
13.38
4.9
2.4
3.93
2.83
mg/l
1.42
45
160
52
212
4.44
11.21
8.6
4.3
15.22
8.57
mg/mmol
0.40
39
130
21
41
6.38
10.93
5.1
6.0
25.54
24.34
mmol/l
0.77
21
41
32
98
4.52
9.93
9.2
9.4
103.66
103.91
mmol/l
0.10
32
98
25
63
5.11
9.84
7.4
6.5
5.95
5.73
kpa
0.48
25
63
13
6
24.94
9.66
7.7
1.2
65.53
5.73
pmol/l
—
13
6
16
18
10.54
8.47
4.6
2.3
24.78
26.22
mmol/l
0.45
16
18
14
12
13.55
8.41
4.4
1.8
15.86
16.74
%
0.34
14
12
15
15
11.74
8.41
10.3
1.4
5.28
5.02
kpa
0.48
15
15
11
6
20.59
7.82
8.2
4.0
2.03
1.10
nmol/l
—
11
6
10
5
22.19
7.31
2.5
2.8
—
—
—
0
0
72
444
4.11
7.28
12.7
6.6
8.44
6.53
mmol/l
4.87
72
415
55
294
3.24
6.86
4.7
2.0
101.74
99.51
pmol/l
0.15
39
141
10
7
15.84
6.57
2.6
2.3
10.10
7.29
%
—
10
7
6
0
+∞
6.32
1.8
0.0
—
—
—
0
0
45
223
3.04
6.26
2.0
1.4
0.76
1.86
u/ml
0.57
16
56
8
5
17.34
5.52
5.9
1.4
—
—
—
0
0
19
62
3.62
5.15
1.3
1.3
406.60
62.62
u/ml
—
5
27
30
131
2.94
5.07
3.5
2.0
—
—
—
0
0
20
69
3.44
4.98
4.3
3.1
—
—
—
0
0
43
233
2.62
4.75
6.5
4.1
0.00
0.00
estimate
-0.00
24
85
7
5
15.00
4.65
1.6
1.2
—
—
—
0
0
9
12
8.19
4.47
1.9
2.6
—
—
—
0
0
19
72
3.08
4.04
11.4
16.9
115.11
120.92
g/l
0.76
19
72
15
50
3.40
3.90
11.1
10.5
0.60
0.71
%
0.50
15
50
15
52
3.26
3.67
11.1
10.2
1.39
1.58
%
0.23
15
52
10
24
4.55
3.31
3.0
2.0
—
—
—
0
0
14
50
3.13
3.26
11.4
10.6
94.43
93.82
%
0.18
14
50
33
187
2.21
3.05
3.2
1.8
1.37
1.48
mg/l
0.06
26
147
8
17
5.05
2.99
3.5
2.1
—
—
—
0
0
9
22
4.42
2.97
3.2
1.9
—
—
—
0
0
43
274
2.09
2.93
6.1
3.8
24.76
23.42
ng/l
0.07
33
163
13
48
3.00
2.86
1.8
1.7
—
—
—
0
0
7
14
5.32
2.78
1.6
1.1
—
—
—
0
0
5
6
8.72
2.78
5.4
1.2
12.20
18.75
ug/l
—
5
6
10
30
3.62
2.70
10.8
4.1
60.08
48.14
%
—
10
30
33
196
2.08
2.66
3.4
3.5
1120.79
766.48
ng/l
0.56
28
168
10
31
3.50
2.61
17.5
3.5
25.45
25.44
mmol/l
—
10
31
11
37
3.24
2.59
5.9
6.6
1.90
1.21
%
0.83
11
37
11
37
3.24
2.59
4.8
6.6
0.70
0.69
%
0.04
11
37
8
21
4.07
2.53
3.5
2.1
—
—
—
0
0
11
38
3.15
2.52
2.2
1.5
—
—
—
0
0
9
27
3.59
2.47
1.3
1.2
—
—
—
0
0
9
28
3.45
2.38
8.1
5.9
23.27
24.37
mmol/l
—
9
28
8
24
3.55
2.24
3.1
2.0
—
—
—
0
0
19
97
2.22
2.20
2.9
1.8
—
—
—
0
0
8
25
3.41
2.15
3.9
2.3
—
—
—
0
0
7
20
3.70
2.10
1.1
1.4
—
—
—
0
0
7
20
3.70
2.10
11.1
1.8
4.33
3.77
mmol/l
—
7
20
5
10
5.22
2.10
1.0
1.1
—
—
—
0
0
6
15
4.20
2.07
3.7
2.6
23.50
27.50
ug/min
—
6
8
6
16
3.94
1.97
4.8
1.9
—
—
—
0
0
48
353
1.77
1.89
3.7
3.0
—
—
estimate
—
0
0
41
288
1.78
1.89
3.9
3.1
38.78
29.38
u/l
1.06
41
273
18
96
2.09
1.87
2.9
1.9
—
—
—
0
0
55
422
1.78
1.86
7.2
4.1
0.00
0.00
estimate
-0.00
24
86
55
424
1.76
1.81
7.3
4.1
0.00
18.25
estimate
0.49
26
89
55
425
1.76
1.79
7.3
4.2
0.00
0.04
estimate
0.49
22
83
44
323
1.71
1.69
7.4
3.8
0.09
0.03
estimate
0.29
22
73
7
25
2.95
1.68
4.1
1.9
—
—
—
0
0
7
25
2.95
1.68
4.0
2.0
—
—
—
0
0
9
37
2.59
1.53
1.6
1.2
—
—
—
0
0
7
28
2.62
1.48
4.4
2.6
3.97
3.67
g/l
—
7
28
5
16
3.24
1.46
2.2
1.9
—
—
—
0
0
34
242
1.65
1.42
6.6
3.2
0.09
0.00
estimate
0.48
22
73
7
31
2.36
1.13
5.6
2.2
83.29
91.39
%
—
7
31
5
21
2.46
1.10
3.0
2.7
—
—
—
0
0
83
768
2.04
1.10
54.4
16.6
139.47
139.66
mmol/l
0.25
83
753
5
22
2.34
1.04
1.4
1.2
—
—
—
0
0
25
178
1.56
1.01
3.8
2.3
—
—
—
0
0
0
30
0.00
0.99
0.0
1.0
—
1.84
—
0
20
83
770
2.00
0.97
54.6
16.7
3.94
3.93
mmol/l
0.11
83
755
6
28
2.22
0.93
1.2
1.2
—
—
—
0
0
9
149
0.56
0.89
2.0
2.5
—
—
—
0
0
18
127
1.52
0.75
4.5
4.7
1.03
1.82
ug/l
1.89
18
116
15
209
0.66
0.70
2.0
1.7
—
—
—
0
0
9
136
0.62
0.67
1.8
2.4
—
—
—
0
0
8
53
1.56
0.60
4.3
2.4
10.12
6.97
ug/l
—
8
47
6
37
1.66
0.57
1.7
1.6
—
—
—
0
0
20
156
1.36
0.51
1.4
1.4
7.76
7.65
u/ml
—
8
74
83
855
0.62
0.50
56.9
22.7
91.08
90.23
fl
1.06
83
849
83
855
0.62
0.50
58.1
23.4
39.06
40.69
%
3.13
83
848
83
855
0.62
0.50
57.9
22.8
128.60
136.18
g/l
5.01
83
848
13
95
1.43
0.47
2.7
2.6
6.62
4.58
umol/l
0.66
13
88
17
131
1.37
0.46
3.6
3.0
0.26
1.02
e6/l
2.00
12
66
80
766
1.40
0.38
38.3
14.9
18.55
22.42
mg/l
0.88
74
612
63
588
1.24
0.36
3.6
3.6
—
—
—
0
0
20
167
1.25
0.32
1.5
1.4
29.10
36.02
iu/ml
—
6
49
7
54
1.32
0.31
1.1
1.0
—
—
—
0
0
7
56
1.27
0.30
1.1
1.3
—
—
—
0
0
23
197
1.23
0.30
7.3
3.7
1.02
1.02
kg/l
0.21
18
125
15
122
1.28
0.29
3.9
3.1
1.30
4.81
e6/l
—
10
58
5
37
1.37
0.24
2.2
2.1
15.20
31.65
u/ml
—
5
37
10
81
1.26
0.19
2.1
2.4
0.30
0.95
ug/l
—
5
40
18
158
1.17
0.18
2.0
1.6
—
—
—
0
0
5
66
0.74
0.17
1.8
1.6
734.88
931.00
mu/l
—
5
55
10
85
1.20
0.13
23.8
8.1
—
—
—
0
0
74
722
1.14
0.12
6.9
3.9
1.21
1.24
mmol/l
0.17
69
676
83
821
1.14
-0.00
55.4
17.6
90.66
72.42
umol/l
1.74
83
812
0
6
0.00
-0.00
0.0
1.5
—
67.83
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.31
—
0
5
0
6
0.00
-0.00
0.0
1.7
—
13.50
—
0
6
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.9
—
1.14
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
8.00
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint E4_DYSPOLYGL and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_DYSPOLYGL.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_DYSPOLYGL – Polyglandular dysfunction
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data