neurodegenerative disease: A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function.
Senile degeneration of the brain, not elsewhere classified
DOID EFO Endpoint Browser PheWeb
G6_DEGENSEN
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
186 |
4. Check minimum number of eventsNone |
186 |
5. Include endpointsNone |
186 |
6. Filter based on genotype QC (FinnGen only) |
161 |
Control definitions (FinnGen only)
- Control exclude
- G6_NEURODEG
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF6
- Parent code in ICD-10
- G31
- Name in latin
- Degeneratio cerebri senilis non alibi classificata
Similar endpoints
↥List of similar endpoints to
Senile degeneration of the brain, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Degenerative diseases of the nervous system
- Other degenerative diseases of the nervous system
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3797 | 1926 | 1743 |
| Only index persons | 1467 | 804 | 663 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.05 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 75.25 | 76.87 | 73.64 |
| Only index persons | 76.36 | 78.22 | 74.12 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 161 | 58 | 103 |
| Unadjusted period prevalence (%) | 0.04 | 0.02 | 0.05 |
| Median age at first event (years) | 73.98 | 74.76 | 73.54 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 164
- Matched controls
- 1639
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G31.1
ICD-10 Finland
Senile degeneration of brain, not elsewhere classified
+∞
169.6
132
*
N06DX01
ATC
memantine; oral
16.8
46.1
43
34
F03
ICD-10 Finland
Unspecified dementia
12.0
42.0
50
58
N06DA02
ATC
donepezil; oral
15.1
36.2
35
29
G30.1
ICD-10 Finland
Alzheimer disease with late onset
36.2
29.1
37
13
N05AX08
ATC
risperidone; systemic
8.0
26.9
43
70
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
37.1
26.2
33
11
3312X
ICD-9 Finland
Other cerebral degenerations, Senile degeneration of brain
+∞
25.7
24
*
G31.0
ICD-10 Finland
Circumscribed brain atrophy
+∞
18.0
17
*
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
56.5
17.4
20
*
N05AH04
ATC
quetiapine; oral
4.5
14.1
41
113
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
6.9
13.8
23
38
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
4.7
13.7
37
96
P20
ICPC
Memory disturbance
3.9
12.9
48
158
N06DA03
ATC
rivastigmine; oral, transdermal
10.5
12.0
23
25
N05BA06
ATC
lorazepam; systemic, sublingual
5.9
11.4
22
42
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
30.4
10.9
14
5
G31.8
ICD-10 Finland
Other specified degenerative diseases of nervous system
105.8
9.5
10
*
G31.9
ICD-10 Finland
Degenerative disease of nervous system, unspecified
+∞
9.5
9
*
G30.8
ICD-10 Finland
Other Alzheimer disease
20.0
9.1
13
7
N03AG01
ATC
valproic acid; systemic, rectal
7.3
8.2
19
29
F00.00*G30.0
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
+∞
7.3
7
*
F0019, G301,
ICD-10 Finland
+∞
7.3
7
*
TAB00
NOMESCO Finland
Lumbar puncture
8.1
7.1
15
20
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.7
6.5
22
66
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.3
6.3
17
43
G30.0
ICD-10 Finland
Alzheimer disease with early onset
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
26
105
2.75
4.74
1.7
1.7
—
—
—
0
0
48
263
2.16
4.51
2.4
1.8
1182.69
1222.46
nmol/l
0.11
36
210
16
53
3.24
4.08
1.3
1.3
—
—
—
0
0
5
7
7.32
2.56
1.0
1.1
—
—
—
0
0
78
948
0.66
1.85
8.8
7.8
42.09
41.35
mmol/mol
0.22
70
874
29
436
0.59
1.78
5.7
4.0
12.15
14.76
mg/mmol
0.16
21
281
8
31
2.66
1.68
1.9
1.5
—
—
—
0
0
8
31
2.66
1.68
1.4
2.4
—
—
—
0
0
39
528
0.66
1.48
3.3
3.6
2092.76
2185.78
ng/l
0.04
34
458
80
945
0.70
1.45
5.0
5.6
4.51
4.26
mmol/l
1.32
67
848
15
81
1.94
1.45
1.5
1.4
—
—
—
0
0
80
940
0.71
1.37
5.0
5.6
1.40
1.42
mmol/l
0.13
69
832
69
556
1.41
1.35
2.5
2.2
89.42
92.00
pmol/l
0.17
33
287
78
915
0.72
1.29
4.6
4.7
1.33
1.24
mmol/l
0.40
65
805
85
978
0.73
1.20
5.7
5.8
6.06
6.17
mmol/l
0.32
77
865
33
236
1.50
1.19
1.8
2.0
—
—
—
0
0
13
73
1.85
1.14
2.1
2.3
7.78
5.24
ug/l
0.12
13
63
85
973
0.74
1.13
5.6
6.5
2.69
2.40
mmol/l
2.32
74
870
8
41
2.00
1.10
1.1
1.5
—
—
—
0
0
34
254
1.43
0.99
6.1
4.8
1.02
1.02
kg/l
0.14
27
165
0
28
0.00
0.98
0.0
2.3
—
2.82
—
0
21
25
176
1.50
0.98
1.9
1.8
—
—
—
0
0
85
959
0.76
0.93
24.0
22.0
70.86
69.28
ml/min/173m2
0.27
78
901
70
597
1.30
0.87
3.8
3.4
49.17
61.12
u/l
0.89
63
548
8
46
1.78
0.84
1.5
1.9
—
—
—
0
0
0
25
0.00
0.79
0.0
1.2
—
—
—
0
0
6
34
1.79
0.77
1.2
1.5
—
—
—
0
0
48
398
1.29
0.73
1.8
1.8
21.12
20.74
nmol/l
0.06
39
316
23
170
1.41
0.72
2.0
1.9
—
—
—
0
0
55
466
1.27
0.70
5.2
3.7
—
—
—
0
0
5
27
1.88
0.69
1.4
2.1
—
—
—
0
0
13
86
1.55
0.68
1.9
1.9
—
—
—
0
0
5
29
1.75
0.64
1.2
1.6
—
—
—
0
0
14
96
1.50
0.63
3.1
3.3
0.87
1.67
mmol/l
—
9
66
69
608
1.23
0.62
5.9
4.6
0.00
10.48
estimate
0.50
17
155
8
51
1.60
0.61
1.5
2.1
—
—
—
0
0
0
20
0.00
0.61
0.0
1.1
—
—
—
0
0
68
602
1.22
0.57
6.0
4.6
0.00
0.00
estimate
-0.00
16
146
23
291
0.76
0.56
2.7
3.6
0.76
0.81
ug/l
0.14
14
201
69
613
1.22
0.56
6.0
4.6
0.00
0.00
estimate
-0.00
16
140
6
37
1.64
0.56
1.3
1.6
—
—
—
0
0
43
368
1.23
0.50
4.8
3.6
0.39
0.52
e6/l
0.32
34
277
36
303
1.24
0.48
2.3
1.8
531.61
450.28
pmol/l
0.41
28
258
48
418
1.21
0.47
3.5
3.1
2.35
2.34
mmol/l
0.09
41
374
16
207
0.75
0.46
1.3
1.2
0.58
1.48
u/ml
—
5
61
56
625
0.84
0.45
5.9
9.5
5.46
4.29
e9/l
1.85
49
534
94
1005
0.85
0.44
30.4
21.6
41.17
28.37
mg/l
1.58
85
873
6
94
0.62
0.43
1.7
1.3
—
—
—
0
0
8
56
1.45
0.43
2.8
3.8
24.40
24.76
mmol/l
—
8
50
0
16
0.00
0.41
0.0
1.3
—
10.13
—
0
16
0
17
0.00
0.41
0.0
1.6
—
15.47
—
0
17
35
404
0.83
0.40
4.5
5.1
20.48
22.87
%
0.55
17
231
63
572
1.16
0.38
8.7
6.7
1.21
1.21
mmol/l
0.09
57
522
58
526
1.16
0.35
3.9
2.8
—
—
estimate
—
0
0
51
460
1.16
0.33
2.4
2.3
—
—
—
0
0
43
383
1.17
0.33
2.9
2.2
2.74
3.16
mg/l
0.68
36
334
32
278
1.19
0.32
2.7
2.4
—
—
—
0
0
47
519
0.87
0.32
7.0
6.4
3.11
3.03
ug/l
0.03
42
449
74
790
0.88
0.30
28.4
27.5
13.90
14.10
%
0.78
74
784
69
642
1.13
0.28
9.7
7.3
1.21
1.21
mmol/l
0.27
60
551
5
72
0.68
0.26
1.2
1.4
—
—
—
0
0
45
492
0.88
0.26
4.0
3.0
160.10
159.69
ug/l
0.00
39
445
50
459
1.13
0.25
6.9
4.8
0.00
0.04
estimate
0.78
14
118
5
37
1.36
0.24
1.2
1.6
—
—
—
0
0
5
38
1.32
0.23
1.2
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
11
89
1.25
0.21
1.2
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
0.87
—
0
6
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
17
146
1.18
0.20
10.5
9.1
—
—
—
0
0
11
90
1.24
0.19
3.7
7.3
21.45
24.34
mmol/l
1.02
11
90
6
52
1.16
0.19
1.8
3.2
—
—
—
0
0
36
331
1.11
0.18
6.9
4.3
0.00
0.00
estimate
-0.00
14
111
5
67
0.74
0.17
1.2
2.2
4.04
4.33
g/l
—
5
59
5
67
0.74
0.17
1.2
2.2
6.48
7.51
g/l
—
5
59
39
361
1.10
0.17
6.0
4.5
0.00
0.02
estimate
0.50
11
130
58
551
1.08
0.15
5.8
5.1
36.26
59.39
ng/l
1.22
51
451
29
267
1.10
0.14
4.3
2.9
2.47
2.47
mmol/l
0.04
23
242
9
110
0.81
0.13
6.4
4.8
1.22
1.20
mmol/l
—
9
97
23
212
1.10
0.11
3.3
3.4
1.26
1.60
e6/l
0.19
13
106
84
863
0.94
0.10
8.2
8.4
77.49
83.25
u/l
0.94
77
810
5
45
1.11
0.10
2.0
2.3
129.40
122.39
g/l
—
5
33
24
224
1.08
0.08
2.8
3.2
1.72
0.91
e6/l
0.23
13
117
5
62
0.80
0.08
1.2
2.3
3.02
2.95
g/l
—
5
54
81
791
1.05
0.07
4.4
4.7
14.67
15.98
mm/h
0.38
72
721
89
907
0.96
0.07
6.1
5.2
1.99
2.08
mu/l
0.29
77
785
50
484
1.05
0.06
2.3
2.5
83.99
78.91
nmol/l
0.52
44
420
76
744
1.04
0.06
4.7
4.0
14.82
15.11
pmol/l
0.32
66
644
19
200
0.94
0.04
5.4
6.5
105.58
104.14
mmol/l
0.79
19
200
16
152
1.06
0.02
4.7
5.4
32.00
31.70
%
0.05
11
92
14
145
0.96
0.00
4.6
4.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.0
—
4.62
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
223.00
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
1.29
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
44.00
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
38.37
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
94.67
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
718.62
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
77.38
—
0
5
5
56
0.89
-0.00
1.2
2.4
0.26
0.44
g/l
—
5
45
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
11
110
1.00
-0.00
2.6
3.2
120.98
334.68
ng/l
2.85
11
100
0
7
0.00
-0.00
0.0
4.0
—
9.79
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_DEGENSEN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DEGENSEN | 2.462 [2.03, 2.98] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.078 |
During the follow-up period (1.1.1998 — 31.12.2019), 693 out of 897 females with G6_DEGENSEN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DEGENSEN | 2.829 [2.17, 3.68] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 543 out of 705 males with G6_DEGENSEN died.
Mortality risk
Mortality risk for people of age
years, who have G6_DEGENSEN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.186% | 0.6% |
| 5 | 1.292% | 3.795% |
| 10 | 3.155% | 8.592% |
| 15 | 6.112% | 15.646% |
| 20 | 10.464% | 25.722% |
Relationships between endpoints
↥Index endpoint: G6_DEGENSEN – Senile degeneration of the brain, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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