Idiopathic urticaria

L12_URTICA_IDIOPAT

urticaria: A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L50.1
  • Hospital discharge: ICD-9 7081
  • Cause of death: ICD-10 L50.1
  • Cause of death: ICD-9 7081

2 out of 7 registries used, show all original rules.

963

4. Check minimum number of events

None

963

5. Include endpoints

None

963

6. Filter based on genotype QC (FinnGen only)

881

Control definitions (FinnGen only)

Control exclude
L12_URTICARIAERYTHEMA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L50
Name in latin
Urticaria idiopathica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5662 3560 2061
Only index persons 5072 3268 1804
Unadjusted period prevalence (%)
Whole population 0.09 0.10 0.06
Only index persons 0.10 0.12 0.07
Median age at first event (years)
Whole population 30.93 35.13 23.53
Only index persons 33.36 36.62 27.47

-FinnGen-

Key figures

All Female Male
Number of individuals 881 672 209
Unadjusted period prevalence (%) 0.20 0.24 0.10
Median age at first event (years) 44.28 42.82 48.97

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
916
Matched controls
9160
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L50.9
ICD-10 Finland
Urticaria, unspecified
55.2
307.7
331
93
L50.8
ICD-10 Finland
Other urticaria
145.7
307.7
167
14
L50.1
ICD-10 Finland
Idiopathic urticaria
11232.0
307.7
847
10
L50.3
ICD-10 Finland
Dermatographic urticaria
96.2
266.0
139
17
L50.0
ICD-10 Finland
Allergic urticaria
27.1
183.3
129
55
R03DC03
ATC
montelukast; oral
6.0
154.2
396
1025
C01CA24
ATC
epinephrine; parenteral
8.3
152.8
236
367
L50
ICD-10 Finland
Urticaria
17.6
148.9
127
83
R06AX27
ATC
desloratadine; oral
5.4
137.8
578
2215
T78.3
ICD-10 Finland
Angioneurotic oedema
33.5
135.7
88
29
H02AB06
ATC
prednisolone; systemic
5.6
130.8
661
2901
XQ800
NOMESCO Finland
Prick test
6.6
111.7
211
399
344
Kela drug reimbursment
Omalizumab
1182.9
109.8
105
*
T78.4
ICD-10 Finland
Allergy, unspecified
8.1
105.7
156
226
R03DX05
ATC
omalizumab; parenteral
1132.1
105.5
101
*
R06AE09
ATC
levocetirizine; oral
4.6
95.7
306
904
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
5.4
92.2
217
498
R06AE07
ATC
cetirizine; oral
4.0
84.5
630
3270
S98
ICPC
Urticaria
29.0
77.0
52
19
7081A
ICD-9 Finland
Urticaria, Idiopathic urticaria
+∞
71.8
68
*
R06AX22
ATC
ebastine; oral
3.3
56.7
278
1056
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
6.4
48.1
84
143
A92
ICPC
Allergy/allergic reaction NOS
5.2
45.2
99
208
H02AB07
ATC
prednisone; oral
3.4
43.2
180
609
L04AD01
ATC
ciclosporin; systemic
9.9
41.0
48
51
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.6
35.0
276
1311
S88
ICPC
Dermatitis contact/allergic
6.5
33.4
56
91
A02BA02
ATC
ranitidine; systemic
2.8
32.2
193
796
ZX112
NOMESCO Finland
Subcutaneous
7.0
30.8
48
72
R03AC02
ATC
salbutamol; inhalant
2.2
26.6
604
4316
E0000UV, ,
ATC
2.0
23.9
450
2956
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
9.6
23.6
28
30
T78.2
ICD-10 Finland
Anaphylactic shock, unspecified
7.6
23.0
33
45
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.2
23.0
98
331
D07AC01
ATC
betamethasone; topical
2.0
22.6
356
2184
XQ802
NOMESCO Finland
Epicutan test
3.9
22.3
67
180
R06AX13
ATC
loratadine; oral
2.3
22.1
199
980
L50.5
ICD-10 Finland
Cholinergic urticaria
+∞
22.0
21
*
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.4
20.1
167
792
S21
ICPC
Skin texture symptom/complaint
2.3
19.4
174
853
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.1
18.6
201
1061
R51.80
ICD-10 Finland
Headache
2.1
17.9
210
1142
N02AX02
ATC
tramadol; systemic, rectal
1.9
17.8
373
2471
D07AB08
ATC
desonide; topical
2.5
17.7
126
556
L50.2
ICD-10 Finland
Urticaria due to cold and heat
37.5
17.7
22
6
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
17.5
203
1098
H02AB04
ATC
methylprednisolone; systemic
2.3
17.4
143
673
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.6
17.2
57
164
J01MA02
ATC
ciprofloxacin; systemic
1.9
17.0
324
2074
J46
ICD-10 Finland
Status asthmaticus
4.5
17.0
42
97
R02
ICPC
Shortness of breath/dyspnoea
2.3
16.8
140
663
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
16.0
384
2628
R03BA02
ATC
budesonide; inhalant
2.0
15.6
195
1079
N05BB01
ATC
hydroxyzine; systemic
2.8
15.4
80
301
D02AX
ATC
Other emollients and protectives
3.8
15.3
48
133
R60.9
ICD-10 Finland
Oedema, unspecified
3.1
15.1
64
215
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
3.1
15.0
66
227
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.2
14.8
60
196
J01AA02
ATC
doxycycline; systemic
1.9
14.8
679
5555
S29
ICPC
Skin symptom/complaint other
1.9
14.6
212
1233
D07AB02
ATC
hydrocortisone butyrate; topical
1.8
14.6
295
1906
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.5
14.6
99
426
L20.0
ICD-10 Finland
Besnier prurigo
2.3
14.6
121
570
A02BC02
ATC
pantoprazole; systemic
1.7
14.2
590
4658
D07AC13
ATC
mometasone; topical
1.8
14.1
268
1696
J01FF01
ATC
clindamycin; systemic
1.8
14.1
250
1549
R01AD08
ATC
fluticasone; nasal
1.8
14.0
293
1910
R06.0
ICD-10 Finland
Dyspnoea
1.8
13.8
245
1517
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
13.7
215
1282
Z71.8
ICD-10 Finland
Other specified counselling
1.7
13.6
379
2671
3DX05, ,
NOMESCO Finland
+∞
13.6
13
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
13.4
381
2698
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.6
13.1
81
333
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.2
13.1
113
541
M79.6
ICD-10 Finland
Pain in limb
1.7
13.0
422
3088
R03AK07
ATC
formoterol and budesonide; inhalant
1.8
13.0
222
1357
A02BC05
ATC
esomeprazole; systemic
1.7
12.6
354
2491
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
5.9
12.3
22
38
M03BC01
ATC
orphenadrine (citrate); systemic
1.8
12.2
229
1435
R60.0
ICD-10 Finland
Localized oedema
2.2
12.1
109
530
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
11.8
406
2995
R03BA08
ATC
ciclesonide; inhalant
2.2
11.7
102
489
D07AA02
ATC
hydrocortisone; topical
1.9
11.7
159
899
L17
ICPC
Foot/toe symptom/complaint
1.7
11.7
291
1972
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
11.6
292
1986
R96
ICPC
Asthma
2.2
11.5
98
466
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
11.4
233
1493
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.7
11.4
306
2115
X49
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified chemicals and noxious substances
8.5
11.3
24
29
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
11.2
584
4746
D07AD01
ATC
clobetasol; topical
1.9
11.1
151
853
R01AD58
ATC
fluticasone, combinations; nasal
1.7
11.1
287
1962
R01AD09
ATC
mometasone; nasal
1.6
11.1
455
3487
J01
ICD-10 Finland
Acute sinusitis
2.4
11.1
76
329
Z3231
NOMESCO Finland
Registered nurse
1.7
11.0
242
1582
R03BB04
ATC
tiotropium bromide; inhalant
2.5
11.0
74
317
H02AB09
ATC
hydrocortisone; systemic
3.9
11.0
32
84
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
11.0
193
1183
R4110
NOMESCO Finland
Physiotherapy
1.7
11.0
239
1558
R06AX26
ATC
fexofenadine; oral
2.3
10.9
89
415
R03BA05
ATC
fluticasone; inhalant
1.8
10.8
190
1164
P01AB01
ATC
metronidazole; oral, rectal
1.6
10.8
380
2802
S02
ICPC
Pruritus
2.9
10.7
52
189
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
10.6
183
1116
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.3
10.4
80
364
Z2221
NOMESCO Finland
Medical doctor
1.7
10.4
259
1748
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
4.0
10.4
29
74
N03AX16
ATC
[U] pregabalin
1.8
10.4
191
1186
L29.8
ICD-10 Finland
Other pruritus
5.0
10.3
22
45
C07AB07
ATC
bisoprolol; oral
1.6
10.2
328
2356
L29.9
ICD-10 Finland
Pruritus, unspecified
3.3
10.2
38
118
J02AC01
ATC
fluconazole; systemic
1.6
10.1
396
2978
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
2.2
10.1
89
429
XQ818
NOMESCO Finland
Conjunctival allergen provocation test
40.5
10.0
12
*
H53.1
ICD-10 Finland
Subjective visual disturbances
2.3
10.0
75
338
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
9.9
373
2779
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.1
9.8
98
497
R20.2
ICD-10 Finland
Paraesthesia of skin
2.2
9.7
83
395
UJF32
NOMESCO Finland
Coloscopy
1.7
9.6
191
1209
J31.0
ICD-10 Finland
Chronic rhinitis
2.1
9.5
95
480
G44.2
ICD-10 Finland
Tension-type headache
1.8
9.5
154
918
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.1
9.5
89
440
A01
ICPC
Pain general/multiple sites
2.0
9.4
104
546
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
9.3
289
2052
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
9.2
111
601
J01DB01
ATC
cefalexin; oral
1.7
9.2
756
6693
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
9.2
199
1289
R05
ICPC
Cough
1.6
9.1
257
1781
M54.0
ICD-10 Finland
Panniculitis affecting regions of neck and back
4.6
9.1
21
46
A04
ICPC
Weakness/tiredness general
1.8
9.1
163
1002
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
9.0
309
2240
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.9
9.0
123
695
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
8.9
270
1904
XQ848
NOMESCO Finland
Dermatological photography
3.4
8.8
31
93
R03AC13
ATC
formoterol; inhalant
2.7
8.8
47
180
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.9
8.8
125
716
J01FA06
ATC
roxithromycin; oral
1.5
8.7
334
2479
J45
ICD-10 Finland
Asthma
1.9
8.7
110
605
X57
ICD-10 Finland
Unspecified privation
3.5
8.7
29
84
N02BE01
ATC
paracetamol; systemic, rectal
1.8
8.7
800
7229
J01FA09
ATC
clarithromycin; systemic
1.6
8.7
290
2088
N01
ICPC
Headache
1.7
8.6
164
1023
R74
ICPC
Upper respiratory infection acute
1.5
8.6
394
3037
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.7
8.5
47
183
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.6
8.5
277
1979
70891
ICD-8 Finland
Urticaria, Recidivans, Chronica
+∞
8.3
8
*
J45.1
ICD-10 Finland
Nonallergic asthma
2.2
8.3
68
318
M03BX02
ATC
tizanidine; oral
1.5
8.3
557
4640
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
8.1
208
1402
N03AX12
ATC
[U] gabapentin; oral
1.8
8.1
135
811
J01FA10
ATC
azithromycin; systemic
1.5
8.1
572
4802
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.7
8.0
171
1099
D01
ICPC
Abdominal pain/cramps general
1.7
8.0
144
883
Z3226
NOMESCO Finland
Physiotherapist
1.7
8.0
156
979
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.0
7.9
89
470
R05
ICD-10 Finland
Cough
1.6
7.9
203
1368
A02BC01
ATC
omeprazole; systemic
1.6
7.8
217
1492
X58
ICD-10 Finland
Exposure to other specified factors
1.7
7.8
150
939
D11
ICPC
Diarrhoea
1.7
7.8
139
852
J20
ICD-10 Finland
Acute bronchitis
1.9
7.7
104
585
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
7.7
179
1178
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.5
7.6
49
206
R83
ICPC
Respiratory infection other
1.5
7.5
301
2240
T88.7
ICD-10 Finland
Unspecified adverse effect of drug or medicament
4.0
7.5
21
54
R03AC03
ATC
terbutaline; inhalant
1.8
7.5
126
759
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
7.4
121
723
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
7.4
80
418
M25.5
ICD-10 Finland
Pain in joint
1.5
7.3
314
2369
XQ810
NOMESCO Finland
Physical test for urticaria
+∞
7.3
7
*
G47.3
ICD-10 Finland
Sleep apnoea
1.6
7.3
177
1175
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.8
7.2
121
727
R53
ICD-10 Finland
Malaise and fatigue
1.5
7.2
240
1716
A97
ICPC
No disease
1.6
7.2
192
1305
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
7.2
236
1682
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
2.2
7.1
57
265
XQ820
NOMESCO Finland
Exposure to medicinal substance
10.1
7.0
13
13
C07AA05
ATC
propranolol; systemic
1.6
7.0
202
1398
UJF30
NOMESCO Finland
Ileoscopy through colon
1.9
7.0
87
477
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
2.9
7.0
31
108
U07
ICPC
Urine symptom/complaint other
2.0
6.9
75
391
M54.4
ICD-10 Finland
Lumbago with sciatica
1.6
6.9
169
1122
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
5.9
6.9
18
31
A08
ICPC
Swelling
2.4
6.9
47
203
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
3.4
6.9
24
72
N06AX16
ATC
venlafaxine; oral
1.7
6.9
148
953
R03AK08
ATC
formoterol and beclometasone; inhalant
2.3
6.8
48
211
J45.8
ICD-10 Finland
Mixed asthma
2.8
6.8
32
115
D02AE01
ATC
carbamide; topical
2.2
6.8
57
270
UKC02
NOMESCO Finland
Cystoscopy
1.9
6.7
91
512
L23.5
ICD-10 Finland
Allergic contact dermatitis due to other chemical products
7.2
6.7
15
21
G01AF02
ATC
clotrimazole; vaginal
2.7
6.7
35
133
L12
ICPC
Hand/finger symptom/complaint
1.6
6.6
171
1150
H01
ICPC
Ear pain/earache
1.7
6.6
136
865
A03
ICPC
Fever
1.6
6.6
194
1347
AA1AD
NOMESCO Finland
CT of head and brain
1.6
6.5
193
1340
R42
ICD-10 Finland
Dizziness and giddiness
1.6
6.5
175
1189
S02.20
ICD-10 Finland
Fracture of nasal bones, closed
3.6
6.5
21
60
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
6.5
323
2498
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
1.9
6.4
86
482
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
6.4
165
1108
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.5
6.4
299
2281
S01AA01
ATC
chloramphenicol; ophthalmic
2.3
6.4
46
204
W84
ICD-10 Finland
Unspecified threat to breathing
14.4
6.4
10
7
WZC30
NOMESCO Finland
Teaching
1.7
6.4
132
841
L01
ICPC
Neck symptom/complaint
1.6
6.3
164
1106
R01AD12
ATC
fluticasone furoate; nasal
1.4
6.3
317
2454
XQ817, ,
NOMESCO Finland
26.9
6.2
8
*
R52.2
ICD-10 Finland
Other chronic pain
2.4
6.2
41
175
M54.5
ICD-10 Finland
Low back pain
1.4
6.2
331
2586
S63.5
ICD-10 Finland
Sprain and strain of wrist
2.3
6.2
46
207
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
2.9
6.1
28
99
S18
ICPC
Laceration/cut
1.4
6.1
373
2984
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
6.1
92
535
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.7
6.1
122
769
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.2
6.1
51
242
U01
ICPC
Dysuria/painful urination
1.8
6.0
86
492
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.6
6.0
134
869
L01BB02
ATC
mercaptopurine; oral
3.9
6.0
17
44

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
306
645
6.62
147.89
1.6
1.3
195.68
239.90
u/ml
0.38
297
597
189
275
8.40
128.57
1.7
1.6
0.23
0.23
g/l
0.58
181
260
191
285
8.20
127.06
1.7
1.6
1.23
1.19
g/l
0.97
183
268
70
18
42.02
115.38
1.1
1.2
1.19
1.18
u/ml
0.00
70
18
72
77
10.06
61.44
1.3
1.3
0.88
4.37
u/ml
0.81
65
39
683
4227
3.42
59.51
7.4
6.2
0.54
0.55
e9/l
0.34
606
3685
683
4237
3.41
59.06
7.5
6.2
0.04
0.04
e9/l
2.42
603
3691
697
4394
3.45
58.27
7.6
6.5
0.18
0.18
e9/l
0.05
624
3876
501
2650
2.97
56.89
6.6
6.2
—
—
—
0
0
687
4339
3.33
56.28
7.5
6.2
1.98
1.97
e9/l
0.09
617
3874
631
3898
2.99
51.72
7.5
6.2
2.72
2.76
%
0.15
614
3669
630
3893
2.98
51.52
7.5
6.3
0.58
0.69
%
5.24
611
3655
630
3900
2.97
51.21
7.7
6.3
7.98
8.47
%
5.08
613
3681
708
4699
3.23
50.18
9.3
9.3
4.11
4.01
e9/l
0.67
634
4111
635
4012
2.90
48.45
7.7
6.2
28.93
29.12
%
0.19
620
3828
628
3964
2.86
47.65
7.5
6.1
56.59
56.61
%
0.01
612
3798
107
232
5.09
47.20
1.1
1.1
3.95
4.26
u/ml
0.10
84
134
113
266
4.71
45.13
1.2
1.2
2.32
3.74
u/ml
0.57
82
148
103
225
5.03
44.99
1.1
1.1
0.63
0.75
u/ml
0.15
69
100
100
226
4.84
41.89
1.1
1.1
1.20
2.46
u/ml
0.96
74
121
276
1280
2.65
37.09
1.6
1.4
483.85
494.30
titre
0.03
52
277
156
599
2.93
29.54
1.2
1.2
—
—
—
0
0
116
374
3.41
29.54
1.7
1.9
3.52
5.62
iu/ml
0.89
24
84
72
170
4.51
28.41
1.1
1.1
0.06
0.32
u/ml
0.97
44
56
73
176
4.42
28.05
1.1
1.1
3.80
7.34
u/ml
0.68
48
78
99
298
3.60
27.98
1.3
1.2
—
—
—
0
0
32
33
10.01
27.79
1.2
1.1
0.87
1.56
u/ml
0.34
26
18
75
196
4.08
25.90
1.1
1.1
2.91
3.78
u/ml
0.21
51
97
391
2406
2.09
25.26
6.2
5.8
—
—
—
0
0
537
3719
2.07
25.04
9.8
10.2
0.00
0.00
e9/l
0.93
415
3057
179
807
2.51
24.44
1.3
1.2
133.67
146.87
u/ml
0.19
59
331
42
72
6.07
23.71
1.1
1.1
0.24
3.00
u/ml
0.97
21
22
73
205
3.78
22.78
1.3
2.0
10.33
10.41
g/l
0.05
67
193
83
258
3.44
22.25
1.4
1.2
—
—
—
0
0
442
2953
1.96
21.70
4.9
3.7
57.67
89.63
e6/l
0.63
317
1961
36
59
6.31
21.24
1.1
1.1
7.72
0.39
u/ml
0.49
20
14
119
492
2.63
19.21
2.5
2.7
68.17
67.35
g/l
0.70
109
461
372
2425
1.90
18.93
3.9
3.1
34.91
62.11
e6/l
0.68
294
1813
323
2046
1.89
17.69
1.6
1.4
2.19
2.19
g/l
0.01
189
1316
715
5840
2.02
17.17
8.9
7.4
74.09
76.22
u/l
0.58
691
5531
295
1830
1.90
17.12
2.7
2.5
323.47
321.00
umol/l
0.17
275
1645
326
2089
1.87
17.10
3.7
3.0
0.30
0.34
e6/l
0.21
252
1481
36
73
5.09
17.00
1.1
1.2
0.37
3.65
u/ml
0.69
18
31
783
6645
2.23
16.51
5.6
4.6
14.39
14.48
pmol/l
0.57
760
6185
209
1166
2.03
16.46
3.1
2.7
4.01
3.63
e6/l
0.16
110
529
74
259
3.02
16.28
1.3
1.3
4.73
9.53
u/ml
0.49
11
43
218
1250
1.98
15.82
3.1
2.6
1.11
0.94
e6/l
0.19
119
609
73
261
2.95
15.46
1.3
1.3
1.66
2.75
u/ml
—
8
25
207
1182
1.97
15.13
3.1
3.4
0.83
0.82
mmol/l
0.17
197
1120
515
3895
1.74
14.68
5.5
5.9
10.36
10.57
umol/l
0.19
489
3696
436
3157
1.73
14.47
5.1
4.6
36.99
36.63
g/l
0.69
416
2978
66
233
2.97
14.30
1.3
1.2
27.03
45.74
u/ml
—
9
24
852
7604
2.72
14.24
7.0
5.5
1.74
1.80
mu/l
1.00
830
7190
259
1623
1.83
14.11
1.5
1.3
11.33
11.52
u/ml
0.01
92
666
144
739
2.13
14.03
2.5
2.3
31.04
34.94
u/l
0.65
121
626
274
1753
1.80
13.91
1.5
1.3
21.53
27.49
iu/ml
0.54
76
510
650
5299
1.78
13.73
5.5
4.3
151.11
1741.88
e6/l
—
9
75
314
2101
1.75
13.62
2.6
2.1
173.34
198.16
u/l
0.18
304
2005
211
1252
1.89
13.61
4.0
3.4
759.56
361.07
ng/l
0.27
127
792
288
1883
1.77
13.52
2.3
1.7
0.78
0.97
mg/l
1.18
235
1430
84
347
2.56
13.49
1.7
1.6
11.66
7.29
u/ml
0.44
13
77
432
3171
1.69
13.25
6.2
6.2
1.21
1.22
mmol/l
0.53
405
2928
87
371
2.49
13.08
1.3
1.2
1.27
1.34
u/ml
—
10
24
489
3717
1.68
13.06
2.9
2.5
73.64
75.13
nmol/l
0.62
469
3429
25
25
10.25
13.03
1.2
1.1
0.16
21.07
u/ml
0.52
19
18
35
87
4.14
12.92
1.2
1.1
—
—
—
0
0
573
4551
1.69
12.85
3.8
3.1
83.58
82.58
ug/l
0.05
551
4327
468
3546
1.65
12.42
3.5
3.2
6.21
6.21
ph
0.02
264
2014
33
81
4.19
12.39
1.2
1.1
—
—
—
0
0
876
8018
3.12
12.25
18.8
12.9
19.25
21.04
mg/l
1.04
767
6480
255
1654
1.75
12.09
3.3
2.6
7.29
7.72
e6/l
0.11
234
1501
159
891
1.95
12.06
1.6
1.4
—
—
—
0
0
313
2150
1.69
12.04
3.9
3.8
7.40
7.40
ph
0.42
217
1508
106
511
2.21
12.03
1.4
1.7
1.20
1.28
g/l
0.38
100
474
427
3183
1.64
11.92
2.2
1.9
94.70
96.76
pmol/l
0.50
241
1689
74
308
2.53
11.70
2.4
2.2
19.88
20.52
s
0.76
69
275
209
1296
1.79
11.50
2.7
2.6
113.48
105.28
ug/g
0.21
166
1037
101
488
2.20
11.39
1.1
1.1
—
1.00
—
0
6
334
2363
1.65
11.32
1.5
1.3
3.17
1.69
u/ml
0.57
71
674
25
55
4.64
10.76
2.0
2.2
12.79
1.42
u/ml
—
8
18
35
102
3.53
10.38
2.2
2.3
—
—
—
0
0
150
870
1.87
10.16
2.7
2.5
6.33
6.38
umol/l
0.01
129
746
63
260
2.53
10.15
1.4
1.3
—
—
—
0
0
44
151
3.01
10.05
1.2
1.3
2.78
5.69
u/ml
1.00
23
68
376
2802
1.58
9.97
3.3
3.1
27.90
29.91
u/l
0.79
364
2658
459
3596
1.55
9.67
6.5
6.7
1.21
1.22
mmol/l
0.06
420
3112
348
2564
1.58
9.60
2.6
2.2
—
—
—
0
0
541
4405
1.56
9.52
4.0
3.5
0.00
0.00
estimate
0.50
94
938
139
803
1.86
9.51
1.3
1.2
—
—
—
0
0
545
4448
1.56
9.47
4.1
3.6
0.00
3.31
estimate
0.80
93
945
541
4426
1.54
9.15
5.4
4.7
6.34
6.45
mmol/l
0.70
510
4091
216
1432
1.67
9.12
2.9
2.8
553.46
525.26
mosm/kgh2o
0.99
192
1262
145
868
1.80
8.81
2.2
2.0
378.84
383.08
nmol/l
0.10
140
816
109
597
1.94
8.75
3.2
3.7
4.61
4.64
pmol/l
0.12
101
533
47
181
2.68
8.72
2.1
3.0
2.11
1.84
index
0.13
18
94
161
1002
1.74
8.55
2.4
2.3
24.44
22.95
%
0.66
155
937
543
4486
1.52
8.47
4.1
3.6
0.00
0.34
estimate
0.50
90
898
667
5763
1.58
8.47
3.4
3.1
40.05
38.62
u/l
0.23
645
5502
185
1201
1.68
8.40
2.4
2.3
15.06
13.79
umol/l
1.10
180
1116
173
1114
1.68
8.08
2.3
2.3
2.42
2.39
g/l
0.31
168
1029
286
2086
1.54
7.94
2.4
2.1
2.43
2.77
mg/l
2.43
249
1796
37
135
2.81
7.62
1.3
1.2
—
—
—
0
0
285
2094
1.52
7.59
4.6
4.5
—
—
—
0
0
91
492
1.94
7.58
1.1
1.1
—
—
—
0
0
249
1778
1.55
7.55
4.6
4.0
—
—
—
0
0
847
7866
2.02
7.45
18.6
14.1
3.90
3.93
mmol/l
2.07
836
7685
91
497
1.92
7.36
1.1
1.2
—
—
—
0
0
338
2587
1.49
7.34
3.0
3.2
2.35
2.36
mmol/l
0.97
315
2384
7
0
+∞
7.30
1.0
0.0
0.27
—
u/ml
—
7
0
845
7851
1.98
7.27
18.3
14.0
139.60
139.60
mmol/l
0.01
836
7687
137
871
1.67
6.66
1.5
1.5
—
—
—
0
0
154
1015
1.62
6.49
2.8
2.0
29.87
29.05
s
0.78
148
984
595
5149
1.44
6.38
3.8
3.4
—
0.29
—
0
7
399
3223
1.42
6.24
2.3
2.0
—
—
—
0
0
880
8359
2.34
6.18
13.9
10.5
25.66
25.32
u/l
0.22
873
8155
197
1393
1.53
6.10
2.3
2.5
2.43
2.43
mmol/l
0.28
176
1251
456
3783
1.41
6.07
3.2
2.7
—
—
estimate
—
0
0
253
1907
1.45
5.67
2.8
2.1
—
—
—
0
0
322
2539
1.41
5.63
2.5
2.1
—
—
—
0
0
135
892
1.60
5.61
1.5
1.4
—
—
—
0
0
228
1688
1.47
5.60
2.9
2.9
971.64
908.43
ng/l
0.11
195
1384
368
2977
1.39
5.51
13.4
8.9
1.18
1.13
inr
1.07
295
2458
774
7126
1.56
5.50
5.7
5.3
37.92
37.91
mmol/mol
0.00
757
6778
302
2374
1.41
5.31
3.0
2.7
—
—
—
0
0
27
104
2.64
5.09
1.2
1.3
—
—
—
0
0
21
71
3.00
5.01
1.1
1.0
—
—
—
0
0
261
2023
1.41
4.92
1.7
1.6
20.55
20.54
nmol/l
0.01
230
1745
29
118
2.51
4.92
1.3
1.3
0.60
15.59
nmol/l
0.49
29
113
318
2562
1.37
4.71
3.9
3.2
45.45
74.39
ng/l
0.35
159
1489
24
91
2.68
4.68
1.3
1.3
2.67
2.81
g/l
0.22
24
67
24
91
2.68
4.68
1.3
1.3
5.92
6.34
g/l
0.50
24
69
179
1308
1.46
4.64
1.7
1.6
—
—
—
0
0
7
5
14.09
4.58
1.0
1.0
—
—
—
0
0
149
1053
1.50
4.56
1.3
1.2
—
—
—
0
0
818
7700
1.58
4.45
4.7
4.4
1.43
1.49
mmol/l
4.27
792
7292
819
7721
1.57
4.31
4.9
4.5
4.66
4.73
mmol/l
1.36
791
7342
10
16
6.31
4.30
1.1
1.0
4.01
0.00
u/ml
—
5
11
23
90
2.60
4.24
1.3
1.3
—
—
—
0
0
824
7787
1.58
4.20
5.4
5.0
2.76
2.80
mmol/l
0.71
799
7387
294
2375
1.35
4.19
3.3
2.5
58.90
61.03
u/l
0.22
272
2203
248
1951
1.37
4.18
3.7
3.5
1.02
1.82
kg/l
0.50
164
1264
64
376
1.75
4.17
2.7
3.0
162.54
153.53
ng/l
0.06
58
337
83
524
1.64
4.16
2.4
2.0
—
—
—
0
0
105
702
1.56
4.15
2.6
2.1
6.06
6.18
ph
0.69
66
441
88
565
1.62
4.13
9.3
8.6
—
—
—
0
0
139
992
1.47
4.05
1.2
1.2
—
—
—
0
0
790
7415
1.48
3.99
4.9
4.3
5.73
5.73
mmol/l
0.07
763
6931
141
1016
1.46
3.91
2.6
2.0
—
—
—
0
0
91
600
1.57
3.83
2.4
2.4
13.19
19.34
au/ml
—
9
63
777
7286
1.44
3.79
4.1
3.8
1.29
1.24
mmol/l
0.94
750
6849
34
168
2.06
3.74
1.2
1.1
2.21
2.43
eliau/ml
0.09
12
82
8
12
6.71
3.68
1.1
1.3
—
—
—
0
0
22
91
2.45
3.66
3.2
2.4
—
—
—
0
0
101
690
1.52
3.64
3.5
2.9
1.68
1.78
%
0.34
91
622
24
104
2.34
3.62
1.3
1.3
—
—
nmol/l
—
0
0
869
8363
1.76
3.59
13.9
11.4
—
—
—
0
0
7
9
7.83
3.56
1.0
1.0
0.05
0.02
u/ml
—
7
9
16
57
2.84
3.53
1.0
1.1
—
—
—
0
0
21
87
2.45
3.49
1.2
1.7
—
—
—
0
0
36
187
1.96
3.48
2.1
2.4
—
—
—
0
0
48
277
1.77
3.37
1.2
1.1
1.80
5.70
eliau/ml
—
6
49
902
8809
2.57
3.28
28.1
19.9
6.85
6.77
e9/l
0.37
893
8643
13
43
3.05
3.26
1.1
1.1
127.79
159.14
iu/ml
0.41
13
43
43
243
1.81
3.24
1.2
1.2
—
—
—
0
0
141
1052
1.40
3.23
3.0
3.1
4.08
4.92
e9/l
1.25
122
945
21
91
2.34
3.19
3.1
5.0
87.41
84.39
u/ml
—
7
31
48
282
1.74
3.18
2.2
2.1
2.47
4.00
iu/l
1.41
19
122
39
215
1.85
3.18
1.7
1.4
319.05
302.78
ug/g
0.16
23
123
128
942
1.42
3.17
1.9
1.4
—
—
—
0
0
901
8802
2.44
3.14
28.1
19.9
266.99
259.87
e9/l
2.90
893
8657
15
56
2.71
3.07
2.7
2.3
—
—
—
0
0
901
8806
2.41
3.06
28.0
19.9
4.53
4.51
e12/l
0.64
893
8646
9
22
4.12
2.88
1.1
1.3
28.00
27.05
s
—
9
22
96
683
1.45
2.87
3.7
4.1
7.38
7.38
ph
0.12
53
402
69
460
1.54
2.82
1.4
1.4
230.98
240.04
miu/ml
0.08
40
230
24
117
2.08
2.79
1.3
1.1
—
—
—
0
0
29
152
1.94
2.78
1.2
1.1
—
—
—
0
0
92
655
1.45
2.74
4.9
4.0
1.67
1.77
mmol/l
0.09
81
558
25
125
2.03
2.73
1.9
1.4
—
—
—
0
0
94
673
1.44
2.72
8.1
9.1
0.51
0.83
mmol/l
0.39
74
552
31
171
1.84
2.57
3.5
3.8
31.65
28.91
mg/l
0.18
26
147
44
270
1.66
2.54
1.3
1.2
—
—
—
0
0
37
217
1.73
2.52
1.1
1.1
3.76
14.00
au/ml
—
7
63
369
3234
1.24
2.51
2.0
1.9
1.39
1.34
mmol/l
0.45
330
2803
12
45
2.69
2.45
1.8
2.7
567.08
659.16
u/ml
0.18
12
45
55
361
1.56
2.44
2.8
3.0
1.02
1.02
ratio
0.35
46
334
28
153
1.86
2.40
2.8
3.5
14.89
2.15
ratio
0.44
15
87
20
97
2.09
2.38
1.0
1.1
8.45
6.50
iu/ml
—
6
24
102
760
1.38
2.38
2.0
2.0
0.00
0.03
estimate
0.78
24
180
31
176
1.79
2.36
1.4
1.2
—
—
—
0
0
93
686
1.40
2.31
8.2
8.9
5.03
5.11
kpa
0.42
88
660
93
686
1.40
2.31
8.2
8.9
12.64
12.91
kpa
0.21
88
663
9
28
3.24
2.31
1.0
1.3
—
—
—
0
0
383
3398
1.22
2.26
3.6
3.4
0.00
0.03
estimate
2.64
75
781
15
66
2.29
2.25
1.0
1.3
—
—
—
0
0
30
172
1.77
2.23
2.0
1.6
31285.82
11873.42
e6/l
0.67
22
126
22
114
1.95
2.22
1.4
1.7
—
—
—
0
0
92
685
1.38
2.17
8.3
9.0
7.42
7.41
ph
0.35
48
381
279
2406
1.23
2.16
3.5
3.4
7.60
7.92
mmol/l
0.51
250
2084
89
661
1.38
2.14
4.8
4.9
0.32
0.15
%
0.36
28
156
119
925
1.33
2.14
2.3
1.6
—
—
—
0
0
62
431
1.47
2.13
1.2
1.1
—
—
—
0
0
35
213
1.67
2.12
2.4
2.2
4.02
5.07
umol/l
0.92
30
158
245
2087
1.24
2.12
1.9
1.7
—
—
—
0
0
80
586
1.40
2.09
4.6
4.2
49.23
26.03
ug/l
0.30
64
470
18
89
2.04
2.07
1.1
1.2
—
—
—
0
0
6
15
4.02
2.04
3.3
2.8
52.75
55.50
%
—
6
15
91
685
1.36
2.02
4.8
4.9
1.45
1.01
%
0.29
30
181
5
11
4.56
1.94
2.2
2.1
—
—
—
0
0
58
407
1.45
1.92
1.5
1.2
—
—
—
0
0
87
657
1.36
1.91
4.4
4.8
0.96
0.69
%
0.24
26
168
68
493
1.41
1.90
2.6
1.8
—
—
—
0
0
83
623
1.37
1.89
2.4
1.9
—
—
—
0
0
83
624
1.36
1.87
2.4
1.9
—
—
—
0
0
18
93
1.95
1.86
1.3
2.1
—
—
—
0
0
83
626
1.36
1.84
2.4
1.9
—
—
—
0
0
5
12
4.18
1.82
1.4
1.0
—
—
—
0
0
41
271
1.54
1.82
3.3
2.4
—
—
—
0
0
35
224
1.58
1.78
1.3
1.1
—
—
—
0
0
83
630
1.35
1.77
2.4
1.9
—
—
—
0
0
27
431
0.62
1.73
1.1
1.1
0.88
0.87
g/l
0.06
27
431
67
494
1.38
1.72
3.6
2.9
76.99
72.28
e9/l
0.35
51
350
310
2753
1.19
1.71
1.6
1.7
—
—
—
0
0
77
582
1.35
1.70
2.4
1.9
—
—
—
0
0
95
746
1.31
1.62
1.4
1.4
28.33
23.84
iu/l
0.62
82
635
27
423
0.63
1.61
1.1
1.1
1.53
1.56
g/l
0.24
27
423
7
26
2.70
1.58
1.1
1.2
—
—
—
0
0
174
1475
1.22
1.57
1.8
1.6
—
—
—
0
0
34
224
1.54
1.56
1.3
1.1
—
—
—
0
0
290
2586
1.18
1.50
3.1
3.0
0.34
0.11
estimate
0.30
76
779
59
437
1.37
1.50
4.4
2.4
—
—
—
0
0
113
922
1.26
1.45
5.7
5.6
1.06
1.04
mmol/l
0.51
106
861
21
126
1.68
1.41
2.3
1.6
—
—
—
0
0
19
112
1.71
1.36
1.5
1.4
341.74
407.01
pmol/l
0.58
19
100
28
183
1.55
1.36
1.3
1.1
—
—
—
0
0
85
677
1.28
1.34
5.1
5.3
0.04
0.68
%
0.59
23
142
47
343
1.39
1.33
2.1
1.8
—
—
—
0
0
14
76
1.86
1.30
1.1
1.1
—
—
—
0
0
16
91
1.77
1.29
1.1
1.9
—
—
—
0
0
193
1686
1.18
1.27
1.9
1.8
—
—
—
0
0
8
36
2.23
1.24
1.9
1.4
130.25
145.34
nmol/l
—
8
36
22
139
1.60
1.24
1.1
1.2
9.33
144.77
iu/ml
—
6
38
9
45
2.01
1.23
1.0
1.1
—
—
—
0
0
5
19
2.64
1.21
1.4
2.6
43.14
43.13
g/l
—
5
19
30
205
1.48
1.21
1.5
1.2
221.30
232.53
u/ml
0.09
23
123
124
1047
1.21
1.18
1.6
1.6
967.56
1195.31
nmol/l
2.57
102
788
8
39
2.06
1.15
2.3
2.8
0.63
0.74
index
—
8
39
5
20
2.51
1.15
1.4
1.0
6.15
5.72
mg/g
—
5
20
106
885
1.22
1.14
1.7
1.7
3.59
3.45
mmol/l
0.50
67
615
31
217
1.44
1.12
2.0
1.8
—
—
—
0
0
7
30
2.34
1.12
1.7
1.8
—
—
—
0
0
72
582
1.26
1.04
1.4
1.4
—
—
—
0
0
17
106
1.62
1.03
2.2
1.5
—
—
—
0
0
17
106
1.62
1.03
2.2
1.5
—
—
—
0
0
17
106
1.62
1.03
2.2
1.5
—
—
—
0
0
17
106
1.62
1.03
2.2
1.5
—
—
—
0
0
53
413
1.30
1.02
1.5
1.6
—
—
—
0
0
9
47
1.92
1.02
1.1
1.1
—
—
—
0
0
34
248
1.39
1.01
10.4
8.9
—
—
—
0
0
7
35
2.01
1.00
1.6
1.7
—
2840.00
—
0
6
41
310
1.34
0.98
2.0
2.1
—
—
—
0
0
5
23
2.18
0.98
1.4
1.0
—
—
—
0
0
7
37
1.90
0.94
1.0
1.6
64.19
72.97
nmol/24h
—
7
37
51
401
1.29
0.94
1.5
1.5
—
—
—
0
0
10
55
1.83
0.92
1.2
1.2
—
—
—
0
0
17
110
1.56
0.91
1.4
1.7
18.34
26.03
ng/l
1.10
17
110
89
1048
0.83
0.89
1.3
1.3
—
—
—
0
0
57
700
0.80
0.86
4.2
3.7
—
—
—
0
0
34
256
1.34
0.86
1.6
1.4
0.54
0.41
nmol/l
0.26
27
209
6
33
1.82
0.79
1.2
1.4
0.00
0.00
estimate
—
6
33
224
2051
1.12
0.78
4.4
4.2
9.61
8.89
mg/mmol
0.07
147
1279
130
1149
1.15
0.77
1.9
1.8
3.55
3.40
ratio
0.44
89
869
220
2013
1.12
0.77
3.7
3.5
44.72
44.71
mg/l
0.00
148
1297
6
34
1.77
0.76
1.2
2.1
46.75
67.08
ug/l
—
6
34
10
59
1.70
0.76
1.1
1.1
—
—
—
0
0
21
150
1.41
0.74
3.2
2.9
5.37
7.73
pmol/l
1.72
21
150
26
193
1.36
0.74
1.2
1.7
—
—
—
0
0
7
38
1.85
0.73
3.3
3.6
—
—
—
0
0
9
55
1.64
0.73
1.0
1.1
—
—
—
0
0
7
41
1.71
0.70
1.0
1.4
131.77
169.82
mmol/24h
—
7
41
21
152
1.39
0.69
1.1
1.1
—
—
—
0
0
48
392
1.24
0.69
1.4
1.5
1.33
1.27
mm
0.34
38
277
30
231
1.31
0.68
1.3
1.5
435.30
459.79
mg/l
0.18
30
219
5
28
1.79
0.66
1.0
1.1
—
—
—
0
0
5
28
1.79
0.66
1.0
1.1
—
—
—
0
0
5
28
1.79
0.66
1.0
1.1
—
—
—
0
0
5
29
1.73
0.64
1.2
2.3
2.08
1.32
ug/l
—
5
29
5
29
1.73
0.64
2.4
2.7
14.62
17.12
umol/l
—
5
29
62
527
1.19
0.62
1.5
1.6
271.21
308.14
mu/l
0.60
53
479
23
173
1.34
0.62
2.0
1.3
178.89
149.90
au/ml
—
9
47
11
71
1.56
0.62
1.2
1.6
8.15
11.01
umol/l
1.61
11
66
130
1172
1.13
0.60
5.0
4.7
1.73
2.15
ug/l
0.39
123
1064
8
51
1.57
0.60
4.4
2.2
—
—
—
0
0
11
72
1.53
0.59
1.1
2.2
47.63
44.96
%
0.33
11
72
8
53
1.51
0.58
4.3
2.8
945.38
1097.75
mg
—
8
53
26
202
1.30
0.57
1.2
1.7
30.24
16.08
e6/l
0.20
21
153
82
720
1.15
0.57
2.1
2.3
12376.60
6050.93
u/l
0.60
30
297
6
37
1.63
0.55
1.0
1.4
19328.33
35106.16
e6/l
—
6
19
26
205
1.28
0.53
1.2
1.7
93.67
134.36
e6/l
0.19
21
160
9
63
1.43
0.52
1.1
1.2
—
—
—
0
0
6
41
1.47
0.50
1.2
1.8
0.91
1.27
nmol/l
—
6
33
6
41
1.47
0.50
1.0
1.4
1407.67
2377.00
e6/l
—
6
27
10
143
0.70
0.48
5.6
2.8
—
—
—
0
0
47
403
1.18
0.46
1.8
2.0
0.09
0.01
estimate
0.43
23
145
9
129
0.69
0.43
4.6
2.7
9.64
9.13
kpa
—
9
129
9
129
0.69
0.43
4.6
2.7
4.80
4.91
kpa
—
9
129
5
31
1.62
0.43
1.0
1.1
22.82
47.52
iu/ml
—
5
31
0
15
0.00
0.41
0.0
3.0
—
3586.50
—
0
8
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
16
0.00
0.41
0.0
2.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.5
—
—
—
0
0
0
18
0.00
0.40
0.0
2.9
—
363.54
—
0
13
8
61
1.31
0.39
6.8
3.2
—
—
—
0
0
5
35
1.43
0.39
2.0
2.7
9.80
10.05
mg/l
—
5
28
0
19
0.00
0.39
0.0
5.3
—
25.40
—
0
19
0
19
0.00
0.39
0.0
1.2
—
7.36
—
0
13
20
160
1.26
0.39
1.2
1.1
—
—
—
0
0
5
37
1.35
0.37
1.2
1.6
108.20
84.95
ng/l
—
5
37
23
189
1.22
0.36
2.0
1.3
—
—
—
0
0
6
42
1.43
0.35
2.3
2.3
55.00
50.32
umol/l
—
6
36
6
42
1.43
0.35
5.2
2.2
205.83
143.14
nmol/l
—
6
37
11
82
1.35
0.34
1.1
1.1
125.82
113.52
pmol/l
0.50
11
82
58
521
1.12
0.33
2.6
2.4
9.92
12.46
nmol/l
1.59
52
488
6
46
1.31
0.33
1.3
2.6
—
—
—
0
0
56
622
0.89
0.32
2.0
1.7
—
—
—
0
0
250
2399
1.06
0.31
4.0
3.7
0.00
0.01
estimate
1.47
90
903
59
534
1.11
0.30
1.5
1.5
63.66
61.41
ug/l
0.14
50
453
7
54
1.30
0.30
1.0
1.4
73.00
69.46
umol/l
—
7
54
117
1095
1.08
0.30
1.8
1.9
—
—
—
0
0
11
84
1.31
0.30
1.4
1.4
—
—
—
0
0
77
708
1.10
0.30
2.6
3.0
0.72
0.74
ug/l
0.05
41
412
8
107
0.75
0.29
3.3
2.0
—
—
—
0
0
30
262
1.15
0.27
2.5
3.9
217.25
319.51
mg/l
0.48
12
117
88
941
0.93
0.25
1.6
1.6
870.21
998.21
mu/l
1.01
75
796
47
426
1.11
0.25
1.5
1.5
0.26
0.27
mg/l
0.08
18
181
9
76
1.19
0.24
1.2
1.2
—
—
—
0
0
10
78
1.29
0.24
1.5
2.9
—
—
—
0
0
15
124
1.21
0.24
1.3
1.3
—
—
—
0
0
5
39
1.28
0.23
1.0
1.1
—
—
—
0
0
5
39
1.28
0.23
1.0
1.3
—
—
—
0
0
5
40
1.25
0.22
1.0
1.5
—
—
—
0
0
5
41
1.22
0.22
1.2
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
3.0
—
0.20
—
0
11
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
23
201
1.15
0.21
6.9
2.6
7.39
7.41
ph
1.92
23
201
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
73.80
—
0
5
153
1471
1.05
0.19
1.5
1.6
62879217.07
29583434.16
pmol/l
0.22
132
1271
41
376
1.09
0.19
1.4
1.5
10.63
9.83
u/l
0.12
29
300
7
59
1.19
0.18
1.7
1.1
1101.71
1550.17
miu/ml
—
7
59
11
92
1.20
0.16
1.3
1.1
30.82
40.27
mg/l
0.52
11
68
52
555
0.93
0.16
2.9
3.4
1.24
1.23
mmol/l
0.25
40
471
8
72
1.11
0.16
1.5
1.3
1.88
1.41
nmol/l
—
8
65
21
187
1.13
0.16
4.4
4.5
8.48
8.44
kpa
0.04
21
187
10
83
1.21
0.15
1.7
2.2
—
—
—
0
0
348
3543
0.97
0.15
2.7
2.8
—
—
—
0
0
15
131
1.15
0.14
1.1
1.4
7.01
7.10
mmol/l
0.06
15
111
13
148
0.88
0.12
3.6
3.6
3.97
4.21
e9/l
0.23
13
148
67
640
1.05
0.12
2.7
3.5
7.33
7.34
ph
0.11
47
457
10
86
1.16
0.11
1.2
1.1
224.60
217.87
mg/l
—
10
71
18
197
0.91
0.10
3.1
3.3
57.22
57.43
%
0.02
18
197
28
299
0.93
0.09
5.5
4.4
—
—
—
0
0
5
48
1.04
0.09
1.0
1.7
—
83.57
%
—
0
7
6
55
1.09
0.09
1.7
2.7
—
—
—
0
0
5
64
0.78
0.08
2.6
1.4
0.60
0.48
e9/l
—
5
64
22
236
0.93
0.08
1.3
1.3
—
—
—
0
0
17
156
1.09
0.08
1.2
1.9
—
10.60
—
0
5
7
67
1.05
0.08
1.0
1.6
1.84
1.91
mmol/l
—
7
61
12
133
0.90
0.07
4.7
2.9
7.70
7.36
mmol/l
0.26
12
128
41
426
0.96
0.06
4.9
3.9
7.41
7.42
ph
0.30
35
352
17
158
1.08
0.06
1.4
1.2
—
—
—
0
0
16
171
0.93
0.05
4.3
2.8
1.49
1.46
mmol/l
0.10
16
164
14
150
0.93
0.04
3.0
4.2
13.96
26.44
mg/l
—
8
104
224
2256
0.99
0.03
3.4
3.0
—
0.80
—
0
5
40
390
1.03
0.02
1.4
1.3
—
—
—
0
0
16
166
0.96
0.00
1.8
2.2
140.73
131.90
g/l
1.00
11
136
25
244
1.03
0.00
6.0
4.8
1.41
1.32
mg/l
0.28
25
224
13
128
1.02
0.00
1.3
1.7
8.48
7.65
mmol/l
0.59
13
122
14
142
0.99
0.00
1.1
1.8
—
2306.67
—
0
6
15
153
0.98
0.00
3.3
4.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
0.13
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
33.93
—
0
6
7
69
1.01
-0.00
4.4
2.3
1.18
1.19
mmol/l
—
7
69
0
5
0.00
-0.00
0.0
1.0
—
3.70
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
16.15
—
0
9
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
7
69
1.01
-0.00
4.4
2.3
106.57
106.28
mmol/l
—
7
69
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
69
1.01
-0.00
4.4
2.3
3.96
3.94
mmol/l
—
7
69
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
5
50
1.00
-0.00
1.0
1.2
7.60
8.46
mm/h
—
5
50
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
7.3
—
—
—
0
0
6
66
0.91
-0.00
1.2
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
314.00
—
0
5
0
6
0.00
-0.00
0.0
3.0
—
192.67
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_URTICA_IDIOPAT and mortality.

Females

Parameter HR [95% CI] p-value
L12_URTICA_IDIOPAT 1.082 [0.86, 1.37] 0.511
Birth year 0.995 [0.99, 1.0] 0.272

During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 2558 females with L12_URTICA_IDIOPAT died.

Males

Parameter HR [95% CI] p-value
L12_URTICA_IDIOPAT 1.073 [0.8, 1.43] 0.632
Birth year 0.991 [0.98, 1.0] 0.045

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 1446 males with L12_URTICA_IDIOPAT died.

Mortality risk

Mortality risk for people of age

years, who have L12_URTICA_IDIOPAT.

N-year risk Females Males
1 0.094% 0.229%
5 0.676% 1.245%
10 1.577% 3.287%
15 3.005% 6.357%
20 5.357% 10.726%

Relationships between endpoints

Index endpoint: L12_URTICA_IDIOPAT – Idiopathic urticaria

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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