No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleonly females |
313377 |
2. Check conditionsNone |
313377 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
580 |
4. Check minimum number of eventsNone |
580 |
5. Include endpointsNone |
580 |
6. Filter based on genotype QC (FinnGen only) |
526 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
HSIL lesion of the vagina
based on the number of shared cases.
Similar with more cases:
- All dysplastic lesions of the vagina
- HSIL lesion of the cervix uteri, vagina or vulva
- All dysplastic lesions of the cervix uteri, vagina or vulva
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2714 | 2714 | - |
| Only index persons | 2571 | 2571 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | - |
| Only index persons | 0.09 | 0.09 | - |
| Median age at first event (years) | |||
| Whole population | - | 49.94 | - |
| Only index persons | - | 48.76 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 526 | 526 | - |
| Unadjusted period prevalence (%) | 0.19 | 0.19 | - |
| Median age at first event (years) | 51.21 | 51.21 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 540
- Matched controls
- 5400
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
23.1
316.6
373
476
N89.1
ICD-10 Finland
Moderate vaginal dysplasia
+∞
307.7
298
*
LEB00
NOMESCO Finland
Biopsy of vagina
112.8
307.7
285
53
ULA02
NOMESCO Finland
Kolposcopy
41.4
307.7
429
461
LEB30
NOMESCO Finland
Destruction of lesion of vaginal mucosa
523.3
307.7
266
10
N89.2
ICD-10 Finland
Severe vaginal dysplasia, not elsewhere classified
+∞
296.0
256
*
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
16.0
230.2
262
300
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
13.1
209.2
330
580
8077/2-C52.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vagina, NOS
+∞
203.4
182
*
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
15.2
169.3
173
162
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
16.6
120.4
109
81
N87.0
ICD-10 Finland
Mild cervical dysplasia
14.9
116.9
113
94
A63.0
ICD-10 Finland
Anogenital (venereal) warts
14.8
113.3
110
92
LDA10
NOMESCO Finland
Curettage of cervix uteri
9.8
105.3
142
190
N89.0
ICD-10 Finland
Mild vaginal dysplasia
187.8
104.4
106
7
N87.1
ICD-10 Finland
Moderate cervical dysplasia
14.9
101.0
96
77
R87.5
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal microbiological findings
16.2
92.4
83
60
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
18.1
88.0
74
47
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
13.3
85.8
87
77
LDB20
NOMESCO Finland
Electrocoagulation or laser therapy of cervix uteri
21.2
67.5
52
27
ZXC10
NOMESCO Finland
Use of laser
11.1
44.6
49
48
N90.1
ICD-10 Finland
Moderate vulvar dysplasia
233.1
42.5
43
*
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
15.2
36.8
33
23
N90.2
ICD-10 Finland
Severe vulvar dysplasia, not elsewhere classified
64.9
36.7
42
7
LFB20
NOMESCO Finland
Destruction of lesion of vulva or perineum
33.1
30.8
40
13
LEB10
NOMESCO Finland
Excision of lesion of vagina
32.2
29.9
39
13
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.6
25.3
286
1650
D06BB10
ATC
imiquimod; topical
4.3
22.4
61
154
N90.0
ICD-10 Finland
Mild vulvar dysplasia
38.9
21.0
26
7
D07.2
ICD-10 Finland
Carcinoma in situ: Vagina
+∞
19.9
19
*
8077/2-C51.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vulva, NOS
38.1
17.7
22
6
6230B
ICD-9 Finland
Noninflammatory disorders of vagina, Dysplasia of vagina[DYSPLASIA VAGINAE MODERATA]
+∞
16.8
16
*
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
2.2
14.0
395
3011
L04AA06
ATC
mycophenolic acid; systemic
6.7
13.7
22
34
L04AX01
ATC
azathioprine; systemic
3.8
12.1
38
106
N87.9
ICD-10 Finland
Dysplasia of cervix uteri, unspecified
23.9
10.3
14
6
0781C
ICD-9 Finland
Other diseases due to viruses and Chlamydiae, Viral warts[CONDYLOMA ACCUMINATUM]
14.9
10.1
16
11
LEC00
NOMESCO Finland
Partial excision of vagina
56.0
9.7
11
*
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.1
9.3
104
557
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
9.1
223
1539
D06BB04
ATC
podophyllotoxin; topical
2.9
9.0
42
151
A63.8
ICD-10 Finland
Other specified predominantly sexually transmitted diseases
24.5
8.9
12
5
6230C
ICD-9 Finland
Noninflammatory disorders of vagina, Dysplasia of vagina[DYSPLASIA VAGINAE GRAVIS]
+∞
8.4
8
*
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.3
8.2
67
316
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
4.0
8.2
23
59
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
33.9
8.1
10
*
8325
FHL
Coagulation, cryo or laser in anesthesia or operating room
22.4
8.0
11
5
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
11.0
7.8
14
13
R87.7
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal histological findings
15.3
7.7
12
8
C52.91
ICD-10 Finland
Squamous cell carcinoma of the vagina
45.6
7.7
9
*
8070/3-C52.9
ICD-O-3
Squamous cell carcinoma, NOS, of vagina, NOS
45.6
7.7
9
*
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
3.0
7.7
33
113
D07.1
ICD-10 Finland
Carcinoma in situ: Vulva
25.4
7.6
10
*
N89.3
ICD-10 Finland
Dysplasia of vagina, unspecified
81.2
7.4
8
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
7.4
75
386
SAA03
NOMESCO Finland
Extended examination of mouth
1.7
7.4
240
1762
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.0
7.2
32
112
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.1
7.1
75
392
G01AA10
ATC
clindamycin; vaginal
1.8
7.1
132
833
L01BA01
ATC
methotrexate; systemic
3.1
6.9
29
98
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.7
6.8
185
1291
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
40.6
6.8
8
*
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.2
6.7
60
294
8326
FHL
Batch conization
12.4
6.6
11
9
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.2
6.6
26
85
L04AA01
ATC
[U] ciclosporin
6.3
6.5
16
26
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.2
6.4
54
258
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
6.2
246
1871
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.0
6.2
72
390
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
60
28
23.98
81.76
4.3
1.5
—
—
—
0
0
329
1336
4.74
70.15
3.6
1.5
—
—
—
0
0
145
318
5.87
65.88
3.8
1.5
—
—
—
0
0
69
326
2.28
8.45
1.9
1.7
—
—
—
0
0
58
255
2.43
8.35
5.7
1.7
24.91
7.51
iu/ml
1.62
24
56
79
402
2.13
8.06
2.1
1.8
—
—
—
0
0
299
2323
1.64
7.34
3.1
2.6
—
—
estimate
—
0
0
311
2490
1.59
6.36
3.3
2.5
82.13
78.98
nmol/l
1.08
289
2275
79
450
1.89
5.84
5.7
4.5
247.42
242.78
u/l
0.12
73
431
26
94
2.86
5.54
9.2
4.9
591.33
177.22
iu/ml
—
6
9
209
1570
1.54
5.39
3.9
3.1
6.91
6.96
mmol/l
0.06
172
1314
100
628
1.73
5.34
1.9
2.0
—
—
—
0
0
427
3756
1.65
5.31
6.2
4.5
13.15
11.54
mm/h
1.61
398
3519
93
574
1.75
5.28
1.8
1.9
—
—
—
0
0
40
184
2.27
5.24
1.6
1.2
2.64
10.93
u/ml
0.90
12
35
40
184
2.27
5.24
1.5
1.2
3.61
2.01
u/ml
0.36
11
19
19
59
3.30
5.22
1.5
1.1
45.60
68.67
u/ml
—
5
6
264
2098
1.51
5.16
6.7
4.4
36.17
36.36
g/l
0.22
244
1983
37
166
2.32
5.13
1.9
2.3
1.39
1.52
g/l
0.33
31
147
184
1399
1.48
4.27
1.7
1.6
20.56
21.48
nmol/l
0.33
159
1192
37
181
2.12
4.21
1.6
1.5
0.00
0.13
iu/ml
—
5
19
106
719
1.59
4.16
2.3
1.8
—
—
—
0
0
190
1462
1.46
4.13
5.5
4.0
0.00
0.00
estimate
0.80
54
528
12
26
4.70
4.08
1.7
1.8
0.63
0.80
e9/l
0.48
12
26
159
1184
1.49
4.07
2.9
2.2
—
—
—
0
0
54
312
1.81
3.83
11.5
6.8
10.30
8.30
mmol/l
1.47
54
299
190
1490
1.42
3.64
4.6
3.8
10.52
5.61
mg/mmol
0.50
100
826
316
2710
1.40
3.58
5.3
3.9
0.00
0.02
estimate
1.08
57
531
156
1183
1.45
3.58
3.0
2.4
307.93
310.06
umol/l
0.09
143
1051
105
735
1.53
3.57
1.8
1.7
1171.41
1211.22
nmol/l
0.18
86
552
419
3782
1.48
3.55
11.6
7.7
75.76
77.46
u/l
0.42
408
3578
64
399
1.69
3.50
4.7
3.0
121.12
75.37
ng/l
2.18
56
357
13
42
3.15
3.39
1.6
1.4
13808.75
169476.04
e6/l
—
8
28
288
2447
1.38
3.36
9.6
6.1
1.22
1.22
mmol/l
0.03
250
2091
8
14
5.78
3.35
3.6
3.1
0.60
0.61
mmol/l
—
8
14
86
586
1.56
3.30
4.7
4.5
33.43
32.94
%
0.16
60
385
239
1976
1.38
3.28
14.7
10.9
1.18
1.14
inr
0.63
197
1621
78
523
1.57
3.21
2.2
1.8
—
—
—
0
0
26
125
2.13
3.13
1.8
1.2
—
—
—
0
0
331
2895
1.37
3.13
12.9
9.4
3.93
3.96
e9/l
0.10
297
2546
9
20
4.56
3.12
1.3
1.2
—
—
—
0
0
10
25
4.06
3.10
1.8
1.2
—
—
—
0
0
10
25
4.06
3.10
1.8
1.2
—
—
—
0
0
209
1705
1.37
3.06
3.8
3.4
20.21
67.04
ng/l
0.67
120
1067
315
2739
1.36
3.06
5.8
4.4
6.46
6.43
mmol/l
0.11
302
2581
78
533
1.54
2.96
8.7
5.4
—
—
—
0
0
10
27
3.75
2.89
1.4
1.9
—
—
—
0
0
171
1362
1.37
2.88
1.4
1.3
1.48
1.74
u/ml
0.11
48
385
256
2172
1.34
2.85
8.1
5.4
1.22
1.22
mmol/l
0.10
237
1992
309
2696
1.34
2.84
5.3
3.9
0.00
5.44
estimate
0.80
59
557
17
71
2.44
2.83
1.3
1.3
—
—
—
0
0
303
2641
1.34
2.78
3.4
3.2
98.77
82.47
ug/l
1.10
286
2481
18
78
2.35
2.77
3.2
2.5
31.33
30.57
umol/l
0.06
18
70
101
742
1.44
2.69
3.1
2.4
130.24
111.01
ug/g
0.21
78
576
183
1487
1.35
2.68
2.0
2.1
125.37
174.86
u/l
0.56
174
1416
66
446
1.55
2.64
2.7
2.7
22.23
44.64
u/ml
1.32
61
427
155
1235
1.36
2.57
3.3
3.0
817.02
906.56
ng/l
0.25
127
1034
6
11
5.50
2.55
1.5
1.0
—
—
—
0
0
39
233
1.73
2.53
2.2
2.3
43.50
39.90
u/l
0.56
34
211
47
296
1.64
2.52
1.7
1.5
—
—
—
0
0
252
2160
1.31
2.51
2.2
2.1
104.24
98.87
pmol/l
0.70
132
1073
215
1804
1.32
2.50
3.8
3.4
2.37
2.36
mmol/l
0.65
189
1652
51
329
1.61
2.49
2.3
1.6
—
—
—
0
0
7
16
4.42
2.48
2.1
1.1
—
—
—
0
0
7
16
4.42
2.48
2.1
1.1
—
—
—
0
0
8
21
3.85
2.47
4.9
3.5
0.63
0.86
index
—
8
21
17
76
2.28
2.46
1.1
1.1
—
—
—
0
0
64
438
1.52
2.43
7.5
7.5
1.35
1.13
mmol/l
0.14
52
374
20
97
2.10
2.40
1.8
1.7
—
—
—
0
0
28
154
1.86
2.39
1.6
1.2
51.55
59.74
u/ml
—
6
17
8
22
3.67
2.37
1.6
3.3
0.94
1.48
%
—
8
22
30
170
1.81
2.33
2.4
1.9
—
—
—
0
0
301
2667
1.29
2.25
5.3
3.9
0.00
0.00
estimate
0.50
57
541
158
1287
1.32
2.22
3.2
2.3
2.67
2.84
mg/l
0.44
143
1107
145
1167
1.33
2.22
5.5
3.9
1.02
2.32
kg/l
0.50
104
776
28
158
1.81
2.22
2.1
1.8
—
—
—
0
0
61
422
1.50
2.21
1.3
1.3
109.48
132.67
u/ml
0.26
56
397
70
499
1.46
2.19
2.2
1.8
—
—
—
0
0
129
1023
1.34
2.18
3.5
2.6
8.60
8.17
e6/l
0.07
116
940
27
152
1.82
2.16
1.6
1.2
—
—
—
0
0
11
42
2.65
2.15
1.3
1.4
—
—
—
0
0
22
117
1.92
2.09
2.9
2.4
—
—
—
0
0
13
56
2.35
2.06
1.8
1.7
5.02
73.28
u/ml
0.51
13
56
75
550
1.42
2.03
5.4
2.3
7.58
6.18
umol/l
0.26
70
477
95
726
1.37
2.03
3.8
2.3
2.24
2.43
g/l
2.59
90
671
20
104
1.96
2.03
1.1
1.1
28.94
21.23
au/ml
—
5
32
9
33
2.76
1.94
1.0
1.2
—
—
—
0
0
7
22
3.21
1.88
1.4
1.2
—
—
—
0
0
87
665
1.37
1.86
3.8
2.3
26.05
22.26
%
1.19
82
619
37
239
1.59
1.84
2.0
1.6
—
—
—
0
0
146
1208
1.29
1.80
1.7
1.7
1.18
1.00
mg/l
0.41
120
937
26
154
1.72
1.79
1.2
1.2
—
—
—
0
0
6
18
3.36
1.75
2.0
2.3
1.24
1.19
nmol/l
—
6
12
8
31
2.60
1.66
1.0
1.1
—
—
—
0
0
14
69
2.06
1.66
2.1
1.2
—
—
—
0
0
14
69
2.06
1.66
2.1
1.3
—
—
—
0
0
14
69
2.06
1.66
2.1
1.3
—
—
—
0
0
123
1007
1.29
1.64
3.0
2.6
2.46
2.44
mmol/l
0.48
106
914
174
1489
1.25
1.60
4.6
3.1
21.66
42.72
e6/l
1.57
138
1111
8
32
2.52
1.60
1.1
1.2
37.02
27.15
nmol/l
—
8
25
10
43
2.35
1.59
1.0
1.1
141.30
112.35
pmol/l
—
10
43
13
64
2.06
1.55
2.2
1.3
—
—
—
0
0
121
997
1.28
1.53
1.7
1.7
41441863.89
31161585.06
pmol/l
0.09
111
844
5
15
3.35
1.52
1.0
1.3
—
—
—
0
0
5
15
3.35
1.52
1.0
1.1
—
—
—
0
0
33
219
1.54
1.50
1.3
1.3
258.71
241.74
miu/ml
0.10
21
114
13
65
2.02
1.50
2.2
1.3
—
—
—
0
0
13
65
2.02
1.50
2.2
1.3
—
—
—
0
0
27
171
1.61
1.49
1.1
1.2
—
—
—
0
0
10
45
2.25
1.47
2.6
1.8
15.00
17.38
mg/l
—
5
19
487
4692
1.39
1.47
5.4
4.9
5.75
5.77
mmol/l
0.15
452
4362
96
773
1.29
1.45
3.9
2.4
14.46
13.33
umol/l
0.57
91
722
7
28
2.52
1.45
1.1
1.1
2167.00
1753.21
miu/ml
—
7
28
96
774
1.29
1.44
4.1
2.6
1.20
1.19
e6/l
0.01
56
368
6
22
2.75
1.44
1.2
1.4
5.42
5.48
mmol/l
—
6
22
9
39
2.33
1.43
2.6
1.6
—
—
—
0
0
9
41
2.21
1.37
2.4
1.4
—
—
—
0
0
9
41
2.21
1.37
2.4
1.4
—
—
—
0
0
9
41
2.21
1.37
2.4
1.4
—
—
—
0
0
24
151
1.62
1.37
1.0
1.1
5.04
4.31
—
5
25
53
395
1.38
1.35
6.7
2.9
1.29
2.15
mmol/l
1.27
47
345
53
395
1.38
1.35
2.5
2.5
7.62
19.76
au/ml
—
5
37
150
1285
1.23
1.35
4.6
2.9
0.30
0.40
e6/l
0.54
115
914
52
388
1.38
1.32
2.7
3.9
4.84
4.58
pmol/l
0.40
47
346
9
43
2.11
1.31
2.6
1.6
—
—
—
0
0
503
4886
1.43
1.30
21.0
15.4
139.70
139.75
mmol/l
0.13
497
4786
23
146
1.60
1.28
3.7
2.2
1.97
1.34
mg/l
1.80
23
131
283
2590
1.19
1.27
8.7
6.0
9.24
10.00
umol/l
1.16
274
2456
20
123
1.65
1.25
4.5
3.1
3.55
1.99
index
0.49
11
64
503
4890
1.42
1.25
21.3
15.5
3.93
3.92
mmol/l
0.45
495
4774
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
15
85
1.79
1.24
2.9
3.1
0.28
0.41
iu/ml
—
7
50
496
4812
1.38
1.24
21.0
14.0
18.13
20.66
mg/l
1.20
413
3901
12
63
1.93
1.23
1.1
1.2
—
—
—
0
0
65
511
1.31
1.19
2.6
2.1
377.58
376.64
nmol/l
0.01
59
487
24
157
1.55
1.19
1.4
1.2
—
—
—
0
0
6
26
2.32
1.19
2.3
1.4
—
—
—
0
0
6
26
2.32
1.19
2.3
1.4
—
—
—
0
0
6
26
2.32
1.19
2.3
1.4
—
—
—
0
0
6
26
2.32
1.19
2.3
1.4
—
—
—
0
0
11
57
1.95
1.17
1.1
1.1
1.79
1.46
g/l
2.56
11
51
24
158
1.54
1.16
1.4
1.2
—
—
—
0
0
0
35
0.00
1.15
0.0
1.1
—
—
—
0
0
36
259
1.42
1.15
3.7
2.6
121.56
128.68
g/l
1.23
36
253
57
443
1.32
1.14
3.4
3.1
—
—
—
0
0
46
346
1.36
1.14
2.8
2.9
68.11
67.78
g/l
0.10
40
325
53
409
1.33
1.11
2.5
2.4
68.05
69.19
ml/min/173m2
0.06
21
175
33
235
1.43
1.11
4.2
6.7
24.60
24.74
mmol/l
0.09
33
230
14
81
1.75
1.10
2.1
1.6
—
—
—
0
0
9
46
1.97
1.04
1.3
1.3
—
—
—
0
0
9
46
1.97
1.04
1.3
1.3
—
—
—
0
0
17
108
1.59
0.97
2.5
2.0
8.47
6.55
pmol/l
0.36
17
108
176
1576
1.17
0.97
4.3
2.4
61.95
60.06
u/l
0.09
167
1465
128
1116
1.19
0.96
1.5
1.3
4.96
12.14
u/ml
1.16
49
446
23
158
1.48
0.95
1.8
1.3
—
—
—
0
0
39
297
1.34
0.92
2.2
1.4
—
—
—
0
0
8
45
1.79
0.84
1.5
1.2
—
—
—
0
0
18
121
1.50
0.83
1.8
1.5
—
—
—
0
0
516
5073
1.39
0.81
16.1
11.7
23.08
23.66
u/l
0.48
505
4938
0
25
0.00
0.79
0.0
1.0
—
—
—
0
0
127
1127
1.17
0.78
1.7
1.6
—
—
—
0
0
6
34
1.77
0.76
1.2
1.4
—
—
—
0
0
11
67
1.66
0.75
1.4
1.5
7.74
6.95
mmol/l
0.37
11
55
13
83
1.58
0.75
1.3
1.2
—
—
—
0
0
13
83
1.58
0.75
1.3
1.2
—
—
—
0
0
46
371
1.26
0.74
1.5
1.5
—
—
—
0
0
81
695
1.19
0.74
4.7
2.7
3.41
4.54
e6/l
0.60
42
290
7
38
1.85
0.73
1.0
1.1
309.57
297.36
mg/l
—
7
33
7
39
1.81
0.72
1.0
1.0
—
—
—
0
0
9
56
1.62
0.72
1.0
1.1
—
—
—
0
0
39
310
1.28
0.71
2.7
2.3
4.67
5.03
ug/l
0.05
31
279
20
143
1.41
0.71
1.6
2.6
25.64
24.98
mmol/l
0.44
20
143
5
26
1.93
0.71
1.0
1.2
—
—
—
0
0
480
4689
1.21
0.70
17.2
13.3
82.80
83.58
ml/min/173m2
0.37
455
4316
22
161
1.38
0.69
2.0
1.4
253.76
305.79
ug/g
0.42
13
90
133
1196
1.15
0.69
1.4
1.4
22.89
30.29
iu/ml
0.59
39
380
499
4898
1.25
0.66
6.1
5.6
2.80
2.85
mmol/l
0.60
467
4588
219
2040
1.12
0.65
5.3
3.7
0.00
0.03
estimate
1.91
46
439
16
112
1.44
0.64
4.1
3.8
1.46
2.49
ratio
—
10
60
12
79
1.53
0.63
2.4
1.7
—
—
—
0
0
8
51
1.58
0.60
1.1
1.2
71.63
53.37
u/l
—
8
45
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
20
0.00
0.60
0.0
1.0
—
126.85
—
0
20
0
20
0.00
0.60
0.0
1.0
—
95.36
—
0
11
12
80
1.51
0.60
1.3
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
103.00
—
0
12
26
201
1.31
0.60
1.2
1.4
184.88
148.57
pmol/l
0.11
26
196
528
5226
1.46
0.60
30.2
21.8
265.17
265.31
e9/l
0.02
522
5137
494
4851
1.22
0.60
5.4
4.9
4.78
4.87
mmol/l
1.22
465
4562
8
52
1.55
0.59
1.0
1.1
—
—
—
0
0
11
72
1.54
0.59
1.5
1.5
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
8.20
—
0
22
65
560
1.18
0.59
1.7
1.6
1.37
1.34
%
0.22
60
495
6
35
1.72
0.58
2.5
2.3
—
—
—
0
0
39
320
1.24
0.57
1.1
1.0
—
—
—
0
0
44
366
1.22
0.57
3.6
2.3
0.15
0.78
e6/l
1.33
39
343
8
54
1.49
0.57
1.0
1.1
—
—
—
0
0
8
54
1.49
0.57
1.0
1.1
—
—
—
0
0
528
5228
1.45
0.57
30.2
21.8
4.37
4.42
e12/l
1.66
521
5122
356
3428
1.11
0.55
3.9
3.2
56.18
42.11
u/l
0.87
341
3254
9
60
1.51
0.54
1.0
1.2
—
—
—
0
0
528
5230
1.43
0.54
30.4
21.9
131.68
132.50
g/l
0.83
523
5182
9
62
1.46
0.53
1.1
1.5
—
—
—
0
0
16
117
1.38
0.53
1.6
1.5
—
—
—
0
0
6
41
1.47
0.50
1.2
1.1
—
—
—
0
0
12
84
1.44
0.49
5.9
4.1
131.23
2990.94
u/ml
0.49
12
79
468
4589
1.15
0.49
4.4
4.1
1.29
1.23
mmol/l
0.99
428
4255
14
102
1.38
0.47
2.2
1.8
5.83
4.81
mmol/24h
0.66
14
89
5
85
0.58
0.45
1.0
1.5
80.06
52.40
ug/l
—
5
85
17
219
0.77
0.44
1.1
1.1
1.54
1.64
g/l
1.20
17
219
7
51
1.38
0.44
1.0
1.2
—
—
—
0
0
5
33
1.52
0.41
1.0
1.6
127.68
29.95
ug/l
—
5
33
0
15
0.00
0.41
0.0
1.8
—
5.74
—
0
10
11
79
1.40
0.41
5.4
3.6
41.08
40.87
u/ml
0.00
11
79
8
60
1.34
0.40
1.5
1.6
—
—
—
0
0
345
3346
1.09
0.39
3.3
3.3
—
—
—
0
0
16
124
1.30
0.39
1.6
1.4
—
—
—
0
0
26
215
1.22
0.39
3.5
3.1
2.01
1.72
mmol/l
0.16
19
166
30
254
1.19
0.36
1.9
2.0
1713.12
2999.72
u/l
—
10
105
185
1756
1.08
0.36
4.7
3.0
30.82
28.28
u/l
0.59
178
1668
6
42
1.43
0.35
1.0
1.0
—
—
—
0
0
17
211
0.80
0.35
1.4
1.7
258.06
305.83
mu/l
0.80
17
189
11
82
1.35
0.34
1.2
1.1
2.67
1.78
u/ml
—
6
27
6
46
1.31
0.33
1.0
1.0
228.50
209.57
mg/l
—
6
40
7
52
1.35
0.31
1.3
1.1
—
—
—
0
0
489
4834
1.12
0.30
5.3
4.8
1.55
1.59
mmol/l
1.29
455
4525
9
118
0.76
0.27
1.1
1.6
—
—
—
0
0
8
64
1.25
0.27
1.1
1.1
—
—
—
0
0
51
462
1.11
0.27
4.5
2.3
35.14
36.82
u/l
0.13
42
381
426
4194
1.07
0.26
5.5
5.0
14.56
14.57
pmol/l
0.03
397
3912
22
189
1.17
0.24
1.3
1.5
0.17
0.32
mg/l
—
8
80
10
78
1.29
0.24
1.4
1.2
—
—
—
0
0
10
78
1.29
0.24
2.5
2.6
79.02
35.53
ug/min
—
5
52
26
228
1.15
0.23
1.6
2.0
3.73
4.97
mg/l
0.18
18
170
475
4703
1.08
0.21
6.7
6.2
1.79
1.82
mu/l
0.27
449
4426
5
42
1.19
0.21
1.4
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
115.00
—
0
10
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
5
43
1.16
0.21
3.2
4.0
—
—
—
0
0
7
59
1.19
0.18
1.1
1.1
—
—
—
0
0
24
268
0.89
0.17
1.2
1.6
1578.47
1011.21
mu/l
0.91
15
214
27
243
1.12
0.17
1.9
1.5
—
—
—
0
0
14
162
0.86
0.16
1.3
1.5
—
—
—
0
0
461
4571
1.06
0.15
6.5
5.8
38.09
38.34
mmol/mol
0.28
432
4304
224
2189
1.04
0.15
2.2
1.9
1.36
1.33
mmol/l
0.21
183
1889
66
626
1.06
0.15
2.0
2.0
3.33
3.28
ratio
0.13
45
494
7
87
0.80
0.14
2.1
2.3
15.94
16.28
%
—
7
87
11
93
1.19
0.14
1.0
1.1
3.52
2.04
eliau/ml
—
5
49
8
98
0.81
0.14
1.3
1.9
—
—
—
0
0
11
94
1.17
0.13
1.5
1.5
—
—
—
0
0
15
167
0.90
0.11
1.4
1.6
46.83
57.41
ug/l
—
10
134
47
494
0.95
0.10
1.3
1.2
108.44
154.21
u/ml
0.56
18
222
87
845
1.04
0.08
4.4
3.6
181.71
229.19
ng/l
0.14
60
587
9
84
1.07
0.07
1.2
1.3
—
—
—
0
0
15
163
0.92
0.07
1.3
1.5
1.80
1.21
ratio
—
6
102
15
163
0.92
0.07
1.3
1.5
0.84
1.05
ratio
—
6
102
15
163
0.92
0.07
1.3
1.5
0.94
0.96
ratio
—
6
102
10
89
1.13
0.07
1.5
1.5
—
—
—
0
0
21
224
0.93
0.07
1.5
1.2
0.87
0.89
g/l
0.19
21
224
11
99
1.11
0.06
1.5
1.5
—
—
—
0
0
148
1498
0.98
0.04
4.2
3.3
0.00
0.02
estimate
1.15
44
443
14
131
1.07
0.03
2.3
1.5
—
—
—
0
0
12
112
1.07
0.03
1.6
1.5
—
—
—
0
0
49
480
1.02
0.02
4.6
4.1
2.39
10.12
ug/l
4.05
39
384
14
148
0.94
0.02
1.4
1.3
1093.29
467.15
mg/l
0.56
14
139
12
127
0.94
0.01
1.2
1.1
0.33
1.64
u/ml
—
5
68
11
106
1.04
0.00
1.8
2.6
7.91
8.02
kpa
0.07
11
106
46
455
1.01
0.00
1.4
1.3
30.80
29.65
iu/l
0.08
41
399
21
207
1.02
0.00
1.7
1.8
—
—
—
0
0
18
182
0.99
0.00
1.2
1.5
—
—
—
0
0
39
388
1.01
0.00
4.3
3.6
1.24
1.24
mmol/l
0.12
34
337
48
479
1.00
0.00
1.6
1.8
3.44
3.46
mmol/l
0.03
30
342
7
72
0.97
0.00
3.9
7.9
312.71
389.84
umol/l
—
7
67
6
59
1.02
0.00
1.2
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.80
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
99
0.91
-0.00
2.1
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
8.21
—
0
7
0
5
0.00
-0.00
0.0
5.6
—
5.58
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint N14_VAGINAL_HSIL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_VAGINAL_HSIL | 1.265 [1.08, 1.48] | 0.003 |
| Birth year | 0.998 [0.99, 1.01] | 0.566 |
During the follow-up period (1.1.1998 — 31.12.2019), 266 out of 2226 females with N14_VAGINAL_HSIL died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have N14_VAGINAL_HSIL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.089% | No data |
| 5 | 0.774% | No data |
| 10 | 1.998% | No data |
| 15 | 3.721% | No data |
| 20 | 6.738% | No data |
Relationships between endpoints
↥Index endpoint: N14_VAGINAL_HSIL – HSIL lesion of the vagina
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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