No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
231 |
4. Check minimum number of eventsNone |
231 |
5. Include endpointsNone |
231 |
6. Filter based on genotype QC (FinnGen only) |
203 |
Control definitions (FinnGen only)
- Control exclude
- H7_VISUALDISTBLIND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H54
- Name in latin
- Amaurosis unius oculi, amblyopia alterius oculi
Similar endpoints
↥List of similar endpoints to
Severe visual impairment, binocular
based on the number of shared cases.
Similar with more cases:
- Visual impairment including blindness (binocular or monocular)
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1513 | 827 | 679 |
| Only index persons | 1404 | 779 | 625 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 74.74 | 78.44 | 70.27 |
| Only index persons | 74.85 | 78.51 | 70.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 203 | 107 | 96 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 73.13 | 70.94 | 75.58 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 208
- Matched controls
- 2080
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H54.1
ICD-10 Finland
Severe visual impairment, binocular
+∞
301.2
208
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
1085.9
78.7
72
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
16.7
73.2
72
64
S01ED51
ATC
timolol, combinations; ophthalmic
11.2
60.8
82
114
S01EC01
ATC
acetazolamide; systemic
17.5
53.7
48
35
S01EA05
ATC
brimonidine; ophthalmic
18.3
50.9
44
30
Z96.1
ICD-10 Finland
Presence of intraocular lens
7.7
49.2
109
259
S01ED01
ATC
timolol; ophthalmic
12.3
43.9
49
51
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
9.9
40.7
54
71
WX140
NOMESCO Finland
Parabulbar anesthesy
10.7
40.0
49
58
114
Kela drug reimbursment
Glaucoma
7.3
38.8
73
143
XCK00
NOMESCO Finland
Perimetry
9.1
38.0
54
77
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
8.8
34.8
50
72
S01EE01
ATC
latanoprost; ophthalmic
7.3
29.7
51
89
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.3
28.5
80
221
H33.0
ICD-10 Finland
Retinal detachment with retinal break
11.6
28.1
31
31
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
6.9
27.3
49
89
CS494
NOMESCO Finland
Other visual field testing
26.2
26.8
37
17
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
6.4
26.3
51
100
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
31.0
25.8
34
13
S01EX03, ,
ATC
11.4
25.3
28
28
XCK10
NOMESCO Finland
Photography of fundus of eye
5.6
25.2
59
138
Z3229
NOMESCO Finland
Other healthcare associate professional
6.0
25.0
53
113
H54.0
ICD-10 Finland
Blindness, binocular
+∞
24.5
23
*
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
7.3
23.8
39
64
S01EC04
ATC
brinzolamide; ophthalmic
7.9
22.8
34
50
H16.0
ICD-10 Finland
Corneal ulcer
8.2
22.8
33
47
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.2
22.4
57
142
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.2
22.3
133
622
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
85.5
21.1
23
*
H53.1
ICD-10 Finland
Subjective visual disturbances
29.2
21.1
28
11
H54.4
ICD-10 Finland
Blindness, monocular
+∞
20.1
19
*
S01BA01
ATC
dexamethasone; ophthalmic
8.7
20.0
27
35
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
42.8
19.0
23
6
H3603, E103,
ICD-10 Finland
110.1
18.9
20
*
H47.2
ICD-10 Finland
Optic atrophy
196.0
17.8
18
*
CKD15
NOMESCO Finland
Injection of vitreous substitute
46.5
17.6
21
5
H43.1
ICD-10 Finland
Vitreous haemorrhage
17.0
17.2
27
18
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.5
17.1
130
673
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.5
16.9
130
677
H53.4
ICD-10 Finland
Visual field defects
184.2
16.8
17
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
4.0
16.5
58
183
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
4.7
16.3
43
109
CKD40
NOMESCO Finland
Endophotocoagulation of retina
17.6
16.2
25
16
SPAT1216
SPAT
Assessment of functional ability
3.7
15.8
66
234
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
172.4
15.7
16
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.7
15.6
64
224
SPAT1254
SPAT
Administration of medicine
3.7
15.3
63
220
S01BC05
ATC
ketorolac; ophthalmic
5.8
15.1
30
59
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.3
14.4
77
316
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.4
13.8
65
246
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.1
13.8
128
714
S01EE03
ATC
bimatoprost; ophthalmic
14.2
13.8
23
18
CKD20
NOMESCO Finland
Removal of vitreous body substitute
23.1
13.6
19
9
S01BC03
ATC
diclofenac; ophthalmic
16.5
13.4
21
14
A10AB01
ATC
insulin (human); parenteral
6.2
13.2
24
43
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
12.8
13.2
23
20
AA1AD
NOMESCO Finland
CT of head and brain
3.0
13.2
92
437
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
24.5
13.1
18
8
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
3.0
13.1
86
394
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
74.5
12.7
14
*
A10AB04
ATC
insulin lispro; parenteral
6.6
12.4
21
35
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.7
12.4
47
154
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.7
12.2
44
139
A10AC01
ATC
insulin (human); parenteral
4.0
12.1
39
114
Z94.7
ICD-10 Finland
Corneal transplant status
49.7
12.0
14
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.0
11.9
38
110
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
3.0
11.9
69
293
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
5.8
11.8
23
44
127
Kela drug reimbursment
Transplant complication
20.4
11.8
17
9
A10AE04
ATC
insulin glargine; parenteral
3.7
11.7
42
132
H04.10
ICD-10 Finland
Dry eye syndrome
3.8
11.7
40
122
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.4
11.6
32
83
SPAT1234
SPAT
Support of social functional capacity
4.6
11.6
30
74
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
11.6
11
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
126.7
11.5
12
*
S01EC54
ATC
brinzolamide, combinations; ophthalmic
13.8
11.4
19
15
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
4.8
11.1
27
63
H25.8
ICD-10 Finland
Other senile cataract
3.2
11.0
54
207
L04AA06
ATC
mycophenolic acid; systemic
19.1
10.9
16
9
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
29.8
10.9
14
5
A10AB05
ATC
insulin aspart; parenteral
3.9
10.9
35
102
H26.2
ICD-10 Finland
Complicated cataract
22.9
10.8
15
7
SPAT1263
SPAT
Sampling
2.7
10.8
111
627
H26.4
ICD-10 Finland
After-cataract
3.3
10.8
48
173
S01EC03
ATC
dorzolamide; ophthalmic
12.2
10.8
19
17
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
63.3
10.7
12
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
63.3
10.7
12
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
3.2
10.6
52
199
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
17.2
10.5
16
10
Z97.0
ICD-10 Finland
Presence of artificial eye
115.6
10.5
11
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
115.6
10.5
11
*
Z94.0
ICD-10 Finland
Kidney transplant status
34.5
10.5
13
*
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
34.5
10.5
13
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
4.9
10.3
24
54
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
10.9
10.3
19
19
F05
ICPC
Visual disturbance other
9.5
10.0
20
23
S01EA03
ATC
apraclonidine; ophthalmic
17.8
10.0
15
9
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.9
9.9
55
226
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
12.2
9.8
17
15
H33.4
ICD-10 Finland
Traction detachment of retina
57.8
9.7
11
*
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
57.8
9.7
11
*
TCG10
NOMESCO Finland
Removal of sutures from cornea
57.8
9.7
11
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
16.0
9.7
15
10
S01EE05
ATC
tafluprost; ophthalmic
7.6
9.6
22
32
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
104.6
9.5
10
*
L28
ICPC
Limited function/disability (L)
2.7
9.4
65
298
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
9.0
9.3
19
23
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
10.8
9.2
17
17
A11CC03
ATC
alfacalcidol; systemic
10.8
9.2
17
17
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.8
9.2
60
267
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
3.1
9.2
45
171
H34.1
ICD-10 Finland
Central retinal artery occlusion
38.5
9.1
11
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
38.5
9.1
11
*
L04AD02
ATC
tacrolimus; systemic
38.5
9.1
11
*
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
4.2
9.0
25
65
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
7.2
8.9
21
32
SPAT1104
SPAT
Monitoring of emergency patient
4.6
8.9
22
52
A10AA02, ,
ATC
4.6
8.9
22
52
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
4.9
8.8
20
44
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4.9
8.8
20
44
T89
ICPC
Diabetes insulin dependent
5.1
8.8
19
40
H27.0
ICD-10 Finland
Aphakia
52.2
8.8
10
*
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
52.2
8.8
10
*
H18.1
ICD-10 Finland
Bullous keratopathy
52.2
8.8
10
*
A28
ICPC
Limited function/disability NOS
2.6
8.7
70
345
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.7
8.6
21
49
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
21.1
8.6
12
6
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
11.4
8.4
15
14
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.8
8.4
27
78
R3120
NOMESCO Finland
Training in mobility skills
+∞
8.4
8
*
SPAT1229
SPAT
Assessment of need for aid
3.5
8.2
31
100
S01FA01
ATC
atropine; ophthalmic
34.8
8.2
10
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.0
8.1
41
158
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.4
8.1
31
101
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.3
8.1
100
594
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.8
8.1
49
209
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
8.3
8.1
17
22
C03CA01
ATC
furosemide; systemic
2.3
8.0
107
655
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.1
8.0
37
136
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
7.9
95
555
M81.9
ICD-10 Finland
Osteoporosis, unspecified
4.5
7.9
20
48
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
3.2
7.9
34
119
Z49.1
ICD-10 Finland
Extracorporeal dialysis
15.8
7.8
12
8
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.4
7.7
66
332
TK800
NOMESCO Finland
Hemodialysis
9.4
7.7
15
17
H16.2
ICD-10 Finland
Keratoconjunctivitis
26.1
7.6
10
*
SPAT1172
SPAT
Guidance concerning hydration
8.2
7.5
16
21
H44.5
ICD-10 Finland
Degenerated conditions of globe
82.9
7.5
8
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
7.3
7.5
17
25
L16
ICPC
Ankle symptom/complaint
3.1
7.4
33
118
H16.9
ICD-10 Finland
Keratitis, unspecified
11.5
7.4
13
12
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
7.3
88
512
A10AA01, ,
ATC
6.5
7.3
18
30
A10AE05
ATC
insulin detemir; parenteral
3.9
7.2
22
61
F28
ICPC
Limited function/disability (F)
20.9
7.2
10
5
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
20.9
7.2
10
5
H3603, E113,
ICD-10 Finland
12.6
7.2
12
10
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.4
7.2
27
87
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.9
7.1
38
151
H02AB04
ATC
methylprednisolone; systemic
2.7
7.0
42
177
H04AA01
ATC
glucagon; nasal, parenteral
8.7
6.9
14
17
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.7
6.9
41
172
N18.0
ICD-10 Finland
End-stage renal disease
17.4
6.8
10
6
ZXD05
NOMESCO Finland
Urgent procedure
2.2
6.8
77
434
CHD99
NOMESCO Finland
Other filtering operation
41.4
6.8
8
*
S01ED02
ATC
betaxolol; ophthalmic
8.3
6.7
14
18
H3600, E103,
ICD-10 Finland
23.4
6.7
9
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
23.4
6.7
9
*
SPAT1262
SPAT
Handing over of treatment supplies
2.5
6.7
47
214
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.5
6.7
24
75
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.3
6.6
62
322
CKC12
NOMESCO Finland
Photocoagulation of retina
5.7
6.6
18
34
NF1AA
NOMESCO Finland
Hip X-ray examination
3.0
6.5
30
109
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
14.9
6.5
10
7
SPAT1301
SPAT
No procedures
2.1
6.4
81
476
S01EB01
ATC
pilocarpine; ophthalmic
11.5
6.4
11
10
WX142
NOMESCO Finland
Sub-tenon anesthesy
18.7
6.3
9
5
XCD10
NOMESCO Finland
Electrophysiological examination of eye
6.1
6.3
16
28
H54.3
ICD-10 Finland
Mild or no visual impairment, binocular
+∞
6.3
6
*
F94
ICPC
Blindness
+∞
6.3
6
*
S01BA09
ATC
clobetasone; ophthalmic
+∞
6.3
6
*
3852
FHL
Reoperation for another reason
+∞
6.3
6
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.6
6.3
40
174
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.2
6.1
25
85
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
67
195
4.59
21.72
5.8
5.0
32.65
32.60
%
0.01
40
121
60
188
4.08
17.27
11.9
8.7
—
—
—
0
0
133
712
3.41
16.31
5.3
4.5
57.17
43.87
ng/l
0.31
115
541
41
113
4.27
13.84
7.0
3.2
0.48
1.63
mmol/l
0.88
29
86
166
1103
3.50
12.66
8.0
5.3
1971.00
3117.81
e6/l
0.16
13
27
30
70
4.84
12.41
2.3
1.8
—
—
—
0
0
110
591
2.83
12.29
3.7
3.6
1986.35
1796.68
ng/l
0.13
89
506
94
466
2.86
12.23
3.2
2.4
3.95
3.06
mg/l
2.04
75
418
31
76
4.62
12.08
2.6
2.0
—
—
—
0
0
82
389
2.83
11.46
3.1
2.6
—
—
—
0
0
101
539
2.70
11.15
2.7
2.2
172.82
247.76
u/l
0.46
89
506
150
986
2.87
10.75
10.4
5.5
7.70
6.76
mmol/l
2.87
145
935
76
362
2.73
10.37
2.3
1.8
1373.52
1134.47
nmol/l
1.25
53
285
127
780
2.61
10.23
15.3
6.9
1.22
1.21
mmol/l
0.63
107
710
97
529
2.56
9.97
4.6
2.7
54.03
62.70
u/l
0.45
86
490
43
154
3.26
9.74
22.7
7.3
14.88
10.95
mmol/l
1.43
38
143
92
516
2.40
8.61
7.0
4.3
0.00
0.00
estimate
-0.00
16
165
25
69
3.98
8.30
2.4
2.2
24.30
24.98
mmol/l
0.31
25
69
15
15
10.68
8.18
1.0
1.3
—
—
—
0
0
129
864
2.30
7.69
19.0
7.8
1.22
1.21
mmol/l
0.55
106
739
40
157
2.92
7.66
2.6
2.9
5.11
6.76
ug/l
0.38
25
139
30
100
3.34
7.56
1.3
1.3
—
—
—
0
0
52
236
2.60
7.55
20.0
5.9
1.09
1.07
mmol/l
0.16
41
213
73
392
2.33
7.33
2.1
1.8
391.64
438.54
pmol/l
0.57
59
336
65
332
2.39
7.31
2.6
1.9
—
—
—
0
0
113
728
2.21
7.27
4.0
3.0
—
—
estimate
—
0
0
131
896
2.25
7.25
7.0
6.5
11.90
11.94
umol/l
0.01
120
843
20
53
4.07
6.99
1.4
2.0
—
—
—
0
0
16
24
7.13
6.96
14.0
9.8
620.25
173.43
iu/ml
—
8
7
118
784
2.17
6.90
11.1
4.8
33.78
34.94
g/l
1.32
105
731
72
393
2.27
6.89
7.1
4.7
1.02
1.02
kg/l
0.02
47
271
156
1172
2.32
6.52
5.4
4.3
15.25
14.89
pmol/l
0.87
128
1047
58
307
2.23
5.86
6.7
2.7
12.43
12.34
umol/l
0.03
52
280
155
1189
2.19
5.74
6.7
4.4
17.00
13.38
mm/h
1.94
139
1091
95
611
2.02
5.74
7.0
3.5
—
—
—
0
0
111
756
2.00
5.69
2.8
2.3
96.25
94.56
pmol/l
0.11
60
409
108
729
2.00
5.67
6.1
3.2
169.83
130.49
ug/l
0.92
96
683
39
177
2.48
5.57
9.6
4.0
6.10
5.71
kpa
1.48
39
172
89
566
2.00
5.50
7.0
4.0
19.56
10.14
mg/mmol
0.59
63
366
55
292
2.20
5.49
6.9
2.7
2.12
2.28
g/l
1.40
49
266
16
35
4.86
5.30
1.4
1.4
—
—
—
0
0
16
35
4.86
5.30
5.4
1.3
0.69
0.80
nmol/l
—
10
30
159
1253
2.14
5.19
13.3
7.9
87.50
79.84
u/l
0.77
149
1165
52
278
2.16
5.07
7.1
2.7
23.19
21.61
%
0.33
46
255
174
1426
2.35
5.06
6.6
5.3
2.03
1.95
mu/l
0.28
145
1288
31
132
2.58
5.03
12.2
3.5
172.50
80.58
ng/l
2.25
26
115
121
874
1.92
4.98
6.7
4.3
0.11
8.29
estimate
0.49
18
196
27
109
2.70
4.86
2.0
1.8
—
—
—
0
0
34
154
2.44
4.86
8.1
3.2
5.34
4.36
kpa
0.95
34
149
8
7
11.82
4.82
1.0
1.0
1695.38
1777.00
miu/ml
—
8
7
121
881
1.89
4.79
6.7
4.3
0.00
0.00
estimate
-0.00
18
180
183
1544
2.54
4.79
32.9
18.1
25.31
25.42
mg/l
0.01
165
1302
104
722
1.88
4.77
3.6
2.6
74.68
75.80
nmol/l
0.13
89
645
13
26
5.26
4.72
1.9
1.3
—
—
—
0
0
119
865
1.88
4.70
6.8
4.3
0.00
0.00
estimate
-0.00
18
189
83
539
1.90
4.66
2.3
1.8
20.37
20.94
nmol/l
0.11
69
451
185
1574
2.59
4.65
43.2
21.9
4.00
4.00
mmol/l
0.08
177
1544
185
1574
2.59
4.65
43.0
21.8
139.47
139.59
mmol/l
0.20
177
1544
122
898
1.87
4.59
11.1
10.4
4.52
4.30
e9/l
0.41
107
793
34
159
2.36
4.53
5.0
2.7
0.31
0.82
e6/l
0.45
34
153
19
67
3.02
4.35
1.3
1.3
—
—
—
0
0
16
51
3.32
4.31
2.4
4.7
17.99
30.84
mg/l
—
8
34
11
21
5.47
4.20
1.6
1.5
—
—
—
0
0
11
21
5.47
4.20
1.6
1.5
—
—
—
0
0
11
21
5.47
4.20
1.6
1.5
—
—
—
0
0
11
21
5.47
4.20
1.6
1.5
—
—
—
0
0
187
1620
2.53
4.14
41.6
23.6
99.79
81.91
umol/l
2.42
179
1599
11
22
5.22
4.06
1.6
1.5
—
—
—
0
0
11
22
5.22
4.06
1.6
1.5
—
—
—
0
0
9
14
6.66
4.03
1.6
1.3
—
—
—
0
0
174
1469
2.13
4.02
8.1
5.4
6.69
6.05
mmol/l
2.78
144
1333
10
19
5.47
3.88
8.9
2.6
—
—
—
0
0
6
5
12.30
3.78
1.0
1.0
—
—
—
0
0
10
20
5.20
3.74
1.2
1.8
—
—
—
0
0
10
20
5.20
3.74
1.2
1.8
—
—
—
0
0
10
20
5.20
3.74
1.2
1.8
—
—
—
0
0
17
62
2.90
3.69
1.8
2.7
—
—
—
0
0
11
25
4.58
3.68
1.5
1.2
—
—
—
0
0
28
132
2.30
3.66
2.6
1.6
—
—
—
0
0
85
593
1.73
3.57
4.8
3.3
2.34
2.36
mmol/l
0.76
71
536
11
26
4.41
3.56
1.6
1.2
—
—
—
0
0
48
282
1.91
3.53
4.1
3.8
0.81
0.81
mmol/l
0.07
41
265
94
676
1.71
3.53
6.7
4.4
0.19
0.03
estimate
0.37
16
156
32
163
2.14
3.48
2.4
2.5
0.21
0.22
g/l
0.22
32
151
10
22
4.72
3.47
1.1
2.0
—
—
—
0
0
8
14
5.89
3.37
1.0
1.1
—
—
—
0
0
170
1453
1.93
3.36
12.2
6.9
45.05
39.99
mmol/mol
4.43
142
1349
187
1655
2.29
3.33
50.4
27.2
247.96
243.13
e9/l
0.32
179
1624
126
991
1.69
3.31
5.0
3.2
58.92
47.91
u/l
0.60
118
914
187
1656
2.28
3.30
50.3
27.1
4.21
4.41
e12/l
4.61
178
1617
187
1656
2.28
3.30
50.7
27.6
38.10
39.53
%
3.63
179
1637
187
1656
2.28
3.30
50.1
27.1
91.32
91.35
fl
0.03
179
1639
187
1657
2.27
3.28
50.6
27.3
125.31
132.61
g/l
6.93
179
1637
183
1609
2.14
3.26
19.6
12.0
24.15
24.35
u/l
0.06
170
1559
10
24
4.32
3.24
1.2
1.9
—
—
—
0
0
6
8
7.68
3.07
1.2
1.5
—
—
—
0
0
6
8
7.68
3.07
1.2
1.5
—
—
—
0
0
7
12
5.99
3.04
1.4
1.3
—
—
—
0
0
24
115
2.23
3.03
2.8
3.0
54.80
63.40
ml/min/173m2
—
8
42
15
58
2.71
2.94
1.5
2.7
37.67
39.09
u/l
0.12
15
51
7
13
5.53
2.89
1.0
1.2
—
—
—
0
0
7
13
5.53
2.89
1.0
1.2
—
—
—
0
0
6
9
6.82
2.88
1.2
1.9
—
—
—
0
0
6
9
6.82
2.88
1.2
1.9
—
—
—
0
0
6
10
6.14
2.71
1.5
1.8
—
—
—
0
0
6
10
6.14
2.71
1.2
1.6
—
—
—
0
0
6
10
6.14
2.71
1.2
1.6
—
—
—
0
0
21
100
2.22
2.69
5.9
2.7
1.20
1.16
%
0.10
21
100
21
100
2.22
2.69
5.9
2.7
0.66
0.66
%
0.03
21
100
37
220
1.83
2.60
6.2
8.8
11.36
11.45
kpa
0.04
31
207
14
56
2.61
2.59
1.8
1.6
—
—
—
0
0
64
445
1.63
2.59
5.7
3.0
382.13
351.58
umol/l
1.13
53
368
5
7
7.28
2.56
1.0
1.1
15.00
21.29
u/l
—
5
7
5
7
7.28
2.56
1.0
1.1
58.20
60.43
u/l
—
5
7
6
11
5.58
2.56
1.2
1.8
—
—
—
0
0
6
11
5.58
2.56
1.2
1.8
—
—
—
0
0
6
11
5.58
2.56
1.2
1.8
—
—
—
0
0
6
11
5.58
2.56
1.2
1.8
—
—
—
0
0
165
1438
1.71
2.54
24.9
17.8
68.69
75.84
ml/min/173m2
3.23
155
1345
12
45
2.77
2.50
1.1
1.4
—
—
—
0
0
27
147
1.96
2.47
3.1
2.8
64.11
65.68
g/l
0.37
20
133
36
221
1.76
2.28
6.4
8.8
-0.08
1.31
mmol/l
0.73
28
175
167
1477
1.66
2.23
7.0
5.1
4.28
4.46
mmol/l
1.47
144
1349
13
55
2.45
2.17
1.7
1.5
—
—
—
0
0
5
10
5.09
2.08
1.0
1.2
—
—
—
0
0
5
10
5.09
2.08
1.6
1.0
—
—
—
0
0
165
1470
1.59
1.97
7.2
5.0
1.36
1.45
mmol/l
1.80
142
1332
51
362
1.54
1.84
1.7
1.7
1.13
1.49
mg/l
0.58
41
291
11
47
2.42
1.81
1.7
1.3
—
—
—
0
0
68
517
1.47
1.77
3.4
3.1
30.21
32.42
u/l
0.35
68
494
0
48
0.00
1.72
0.0
1.6
—
899.53
—
0
39
38
257
1.59
1.69
2.7
1.8
27.97
29.67
s
1.52
38
250
108
1255
0.71
1.65
29.5
22.8
14.10
13.89
%
0.67
108
1242
157
1404
1.48
1.64
6.2
4.4
1.47
1.25
mmol/l
2.89
133
1260
35
239
1.56
1.50
2.3
1.8
—
—
—
0
0
9
37
2.50
1.50
1.7
1.6
—
—
—
0
0
9
39
2.37
1.45
1.6
2.6
16.67
15.69
%
—
9
39
10
46
2.23
1.42
1.4
1.4
—
—
—
0
0
9
42
2.19
1.35
2.1
1.4
—
0.04
—
0
10
9
42
2.19
1.35
1.9
1.5
—
—
—
0
0
9
43
2.14
1.32
1.0
1.6
—
—
—
0
0
8
34
2.41
1.30
1.4
1.3
—
—
—
0
0
69
553
1.37
1.29
6.8
5.5
1.90
2.30
ug/l
0.52
57
484
165
1514
1.43
1.29
7.5
5.8
2.38
2.56
mmol/l
1.78
143
1375
27
180
1.57
1.29
2.7
3.7
—
—
—
0
0
8
35
2.34
1.28
1.4
1.5
—
—
—
0
0
46
349
1.41
1.19
1.3
1.3
1.00
2.05
u/ml
0.75
13
83
5
23
2.20
0.98
1.0
1.3
—
—
—
0
0
0
29
0.00
0.98
0.0
1.6
—
1.06
—
0
20
0
29
0.00
0.98
0.0
1.6
—
1.18
—
0
20
0
29
0.00
0.98
0.0
1.6
—
1.04
—
0
20
7
36
1.98
0.98
1.0
1.3
52.11
23.03
u/l
—
7
28
0
31
0.00
0.97
0.0
1.7
—
61.55
—
0
26
58
477
1.30
0.89
3.9
3.3
0.84
0.37
e6/l
0.49
50
357
6
30
2.03
0.87
1.5
1.5
—
—
—
0
0
69
587
1.26
0.81
2.3
2.0
1.53
1.31
mmol/l
1.50
55
490
19
134
1.46
0.74
1.3
1.4
—
—
—
0
0
17
118
1.48
0.72
2.7
2.3
12.53
13.66
nmol/l
0.14
12
108
7
43
1.65
0.67
1.6
1.2
—
—
—
0
0
15
103
1.49
0.67
5.3
6.7
24.61
24.32
mmol/l
0.12
15
103
57
485
1.24
0.66
4.8
3.7
0.00
0.03
estimate
0.99
16
144
97
877
1.20
0.62
3.0
2.9
—
—
—
0
0
50
426
1.23
0.58
6.0
4.7
20.94
22.18
%
0.23
30
216
34
280
1.26
0.53
3.8
3.0
1.48
1.21
e6/l
0.18
24
161
25
199
1.29
0.51
2.8
2.8
6.05
8.59
umol/l
0.73
20
177
7
50
1.41
0.45
1.4
1.2
—
—
—
0
0
7
51
1.39
0.44
1.4
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
17
0.00
0.41
0.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
15
190
0.77
0.37
1.3
1.4
—
—
—
0
0
27
229
1.21
0.34
2.7
1.9
—
—
—
0
0
10
74
1.37
0.33
1.4
1.3
—
—
—
0
0
10
131
0.75
0.32
1.1
2.5
—
—
—
0
0
9
117
0.76
0.28
1.1
2.4
—
—
—
0
0
5
39
1.29
0.23
2.0
1.4
—
—
—
0
0
13
156
0.82
0.22
1.5
1.6
1.77
1.63
%
—
8
133
5
41
1.22
0.22
1.2
1.4
—
—
—
0
0
5
41
1.22
0.22
1.2
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
14.35
—
0
10
0
13
0.00
0.21
0.0
1.5
—
60.33
—
0
13
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
28
251
1.13
0.20
1.5
1.3
17.34
8.02
u/ml
—
7
87
31
337
0.91
0.16
4.2
3.9
191.54
207.11
ng/l
0.04
26
276
24
228
1.06
0.05
1.6
1.5
—
—
—
0
0
28
270
1.04
0.03
1.4
1.3
15.09
30.33
iu/ml
—
7
84
27
262
1.04
0.02
3.7
3.3
2.39
2.11
e6/l
0.06
15
144
32
316
1.01
0.00
3.6
3.1
0.76
0.84
ug/l
0.22
22
204
36
365
0.98
0.00
2.7
3.1
2.44
2.47
mmol/l
0.63
30
319
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
-0.00
1.0
2.2
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
-0.00
0.0
1.2
—
118.00
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
7
72
0.97
-0.00
1.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
8.33
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
41.59
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint H7_SEVVISIMPBINOC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_SEVVISIMPBINOC | 1.435 [1.09, 1.88] | 0.009 |
| Birth year | 0.988 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 296 out of 721 females with H7_SEVVISIMPBINOC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_SEVVISIMPBINOC | 1.576 [1.15, 2.15] | 0.004 |
| Birth year | 0.989 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 257 out of 605 males with H7_SEVVISIMPBINOC died.
Mortality risk
Mortality risk for people of age
years, who have H7_SEVVISIMPBINOC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.115% | 0.294% |
| 5 | 0.592% | 1.968% |
| 10 | 1.64% | 4.809% |
| 15 | 3.245% | 9.312% |
| 20 | 5.846% | 15.604% |
Relationships between endpoints
↥Index endpoint: H7_SEVVISIMPBINOC – Severe visual impairment, binocular
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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