obsolete_incontinentia pigmenti achromians: a dermal melanocytic condition affecting the shoulder area. Nevus of Ito often occurs in association with nevus of Ota in the same patient but is much less common, although the true incidence is unknown.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
947 |
4. Check minimum number of eventsNone |
947 |
5. Include endpointsNone |
947 |
6. Filter based on genotype QC (FinnGen only) |
840 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L81
- Name in latin
- Alia hyperpigmentatio melaninalis
Similar endpoints
↥List of similar endpoints to
Other melanin hyperpigmentation
based on the number of shared cases.
Similar with more cases:
- Other disorders of pigmentation
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5087 | 3489 | 1584 |
| Only index persons | 4808 | 3344 | 1464 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.10 | 0.04 |
| Only index persons | 0.10 | 0.12 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 65.20 | 65.37 | 65.10 |
| Only index persons | 65.53 | 65.39 | 65.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 840 | 564 | 276 |
| Unadjusted period prevalence (%) | 0.18 | 0.20 | 0.13 |
| Median age at first event (years) | 65.21 | 63.51 | 68.68 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 873
- Matched controls
- 8730
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L81.4
ICD-10 Finland
Other melanin hyperpigmentation
4503599627370496.0
307.7
871
11
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
16.3
307.7
373
382
L57.0
ICD-10 Finland
Actinic keratosis
8.7
207.6
355
638
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
14.9
130.6
122
94
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
6.9
105.6
187
331
XQ845
NOMESCO Finland
Dermatoscopy
15.5
102.0
92
66
XQ848
NOMESCO Finland
Dermatological photography
12.2
100.9
106
98
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
33.8
88.6
57
18
L82
ICD-10 Finland
Seborrhoeic keratosis
4.3
85.8
311
1004
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
5.4
85.0
199
454
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
9.8
80.9
99
113
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
11.3
79.5
87
85
R23.8
ICD-10 Finland
Other and unspecified skin changes
3.6
70.8
338
1293
ZXC50
NOMESCO Finland
Cryotherapy
8.3
63.9
88
116
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
9.6
46.5
56
62
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
6.6
43.6
73
119
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
6.9
41.4
66
102
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
5.3
40.7
86
175
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
4.2
40.3
116
304
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
7.2
39.5
60
88
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
3.9
39.3
129
372
TQW99
NOMESCO Finland
Other minor procedure on skin
4.5
37.5
97
234
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
4.7
37.4
92
213
D06BB10
ATC
imiquimod; topical
4.4
35.9
98
246
D03.31
ICD-10 Finland
Melanoma in situ in another or unspecified part of the face
38.0
31.8
40
11
ZXC15
NOMESCO Finland
Use of photodynamic technique
8.7
31.1
40
48
127
Kela drug reimbursment
Transplant complication
11.8
31.1
32
28
D22.7
ICD-10 Finland
Melanocytic naevi of lower limb, including hip
7.1
25.6
39
57
TQW80
NOMESCO Finland
Local dermatologic skincare
6.8
25.3
40
61
D22.3
ICD-10 Finland
Melanocytic naevi of other and unspecified parts of face
6.3
25.2
43
71
SPAT1153
SPAT
Removal of sutures
2.1
22.9
342
2068
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
4.8
22.7
52
113
L04AD01
ATC
ciclosporin; systemic
7.2
22.6
34
49
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
8.3
21.9
29
36
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
6.3
21.7
37
61
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
9.0
21.6
27
31
QXE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in uspecified region
19.5
21.4
32
17
ZXC20
NOMESCO Finland
Use of chemical agents
5.4
20.5
41
79
L04AA06
ATC
mycophenolic acid; systemic
7.0
20.1
31
46
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
21.4
20.0
29
14
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
4.3
19.8
52
126
D06BX02
ATC
ingenol mebutate; topical
7.0
19.6
30
44
L04AA01
ATC
[U] ciclosporin
7.6
19.6
28
38
D22.6
ICD-10 Finland
Melanocytic naevi of upper limb, including shoulder
6.7
19.3
31
48
C44.71
ICD-10 Finland
Basocellular carcinoma of the skin of the lower extremity including the hip
7.5
18.7
27
37
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
14.6
18.7
31
22
S18
ICPC
Laceration/cut
1.8
17.3
460
3288
D23.3
ICD-10 Finland
Benign neoplasm: Skin of other and unspecified parts of face
4.3
17.2
45
109
S29
ICPC
Skin symptom/complaint other
2.0
16.1
210
1184
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.0
16.1
200
1108
L81.1
ICD-10 Finland
Chloasma
38.8
15.4
19
5
8742/2-C44.9
ICD-O-3
Lentigo maligna of skin, NOS
38.8
15.4
19
5
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
4.0
15.2
44
115
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
45.9
15.1
18
*
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
5.5
15.0
29
54
E0000UV, ,
ATC
1.8
14.6
374
2599
QXA50
NOMESCO Finland
Skin cryotherapy, unspecified location
15.7
14.5
23
15
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
2.6
14.4
89
367
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
24.2
13.8
19
8
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
5.2
13.7
28
55
Z94.0
ICD-10 Finland
Kidney transplant status
15.0
13.6
22
15
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
4.7
13.1
30
65
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
4.8
11.9
27
58
A02BC05
ATC
esomeprazole; systemic
1.7
11.9
379
2752
L01BC02
ATC
fluorouracil; systemic, topical
9.8
11.8
23
24
SPAT1301
SPAT
No procedures
1.7
11.4
299
2058
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
15.3
11.3
18
12
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
11.3
127
674
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
4.8
11.2
25
53
ZZR00
NOMESCO Finland
Flap of skin
4.1
10.8
30
76
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
9.7
10.3
20
21
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
10.2
311
2211
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
5.4
10.1
20
38
L04AX01
ATC
azathioprine; systemic
3.2
10.1
40
129
D04.7
ICD-10 Finland
Carcinoma in situ: Skin of lower limb, including hip
11.5
10.1
18
16
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
10.1
194
1221
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
10.1
419
3210
SAA03
NOMESCO Finland
Extended examination of mouth
1.6
10.0
325
2348
H04.10
ICD-10 Finland
Dry eye syndrome
2.0
9.9
117
630
SPAT1325
SPAT
Vaccination
1.6
9.6
311
2237
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
9.6
207
1343
L81.9
ICD-10 Finland
Disorder of pigmentation, unspecified
101.1
9.4
10
*
L91.0
ICD-10 Finland
Hypertrophic scar
22.0
9.4
13
6
C44.81
ICD-10 Finland
Overall basocellular carcinoma of the skin
13.8
9.2
15
11
SPAT1312
SPAT
General health counselling
1.6
9.1
266
1863
D03.5
ICD-10 Finland
Melanoma in situ of trunk
11.6
9.1
16
14
D07AD01
ATC
clobetasol; topical
1.8
9.1
144
854
-, ,
ICD-10 Finland
3.5
9.0
30
87
C43.52
ICD-10 Finland
Malignant melanoma on the torso: 'superficial spreading' type
7.6
9.0
20
27
SDA02
NOMESCO Finland
Periodontal treatment, brief
1.6
8.9
300
2171
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
2.3
8.9
68
309
D07AC01
ATC
betamethasone; topical
1.6
8.8
305
2220
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
8.8
273
1937
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
4.2
8.8
23
56
D07AB02
ATC
hydrocortisone butyrate; topical
1.6
8.7
252
1760
E000006, ,
ATC
2.2
8.6
69
321
D03.6
ICD-10 Finland
Melanoma in situ of upper limb, including shoulder
27.8
8.5
11
*
QAA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of head or neck
27.8
8.5
11
*
SAA02
NOMESCO Finland
Basic examination of mouth
1.5
8.4
531
4395
SPAT1141
SPAT
Excision of skin or mucous membrane lesion
2.6
8.3
48
192
A98
ICPC
Health maint/preventive medicine
2.7
8.3
838
7841
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.7
8.2
43
163
S21
ICPC
Skin texture symptom/complaint
1.8
8.1
144
882
SAA01
NOMESCO Finland
Simple examination of mouth
1.5
8.1
583
4941
C43.31
ICD-10 Finland
Malignant melanoma of another or unspecified part of the face originating in lentigo maligna
33.7
8.1
10
*
8090/3-C44.6
ICD-O-3
Basal cell carcinoma, NOS, of skin of upper limb and shoulder
17.4
8.1
12
7
WX704
NOMESCO Finland
Intubation
2.1
8.0
79
398
S08
ICPC
Skin colour change
2.3
8.0
59
264
TQW40, ,
SPAT
1.9
8.0
103
571
D04.4
ICD-10 Finland
Carcinoma in situ: Skin of scalp and neck
7.3
8.0
18
25
S82
ICPC
Naevus/mole
1.8
7.8
133
806
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
7.7
305
2272
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
45.4
7.7
9
*
4056, ,
NOMESCO Finland
45.4
7.7
9
*
A12AA04
ATC
calcium carbonate; oral
6.0
7.7
20
34
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
7.7
268
1943
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
12.0
7.6
13
11
C44.52
ICD-10 Finland
Spinocellular carcinoma of the skin on the torso
12.0
7.6
13
11
137
Kela drug reimbursment
Uraemia requiring dialysis
10.1
7.5
14
14
SPAT1260
SPAT
Consultation of another employee
1.7
7.5
154
980
QBA50
NOMESCO Finland
Cryotherapy of skin of trunk
80.8
7.4
8
*
L84
ICD-10 Finland
Corns and callosities
3.2
7.3
29
94
UJF32
NOMESCO Finland
Coloscopy
1.6
7.3
236
1678
QDE99
NOMESCO Finland
Other excision or repair of lesion of skin of lower limb
11.0
7.3
13
12
Z01.2
ICD-10 Finland
Dental examination
1.5
7.3
369
2887
L85.3
ICD-10 Finland
Xerosis cutis
7.4
7.2
16
22
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
2.2
7.2
58
270
H13
ICPC
Plugged feeling ear
1.6
7.2
184
1240
SPAT1263
SPAT
Sampling
1.5
7.1
348
2702
L04AD02
ATC
tacrolimus; systemic
8.9
7.1
14
16
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
10.1
7.0
13
13
B07.9
ICD-10 Finland
Verruca simplex
2.9
7.0
32
113
D10AX03
ATC
azelaic acid; topical
2.4
7.0
46
196
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.0
7.0
75
391
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.5
6.9
231
1654
C43.50
ICD-10 Finland
Malignant melanoma of the torso without histology
11.0
6.8
12
11
KMAK, ,
NOMESCO Finland
1.5
6.8
391
3124
D23.5
ICD-10 Finland
Benign neoplasm: Skin of trunk
3.2
6.8
26
83
EMAK, ,
NOMESCO Finland
2.7
6.7
35
133
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
6.7
112
674
L50.3
ICD-10 Finland
Dermatographic urticaria
3.8
6.7
20
54
F16
ICPC
Eyelid symptom/complaint
2.3
6.6
49
220
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
6.6
334
2597
L50.9
ICD-10 Finland
Urticaria, unspecified
2.7
6.6
35
134
D23.1
ICD-10 Finland
Benign neoplasm: Skin of eyelid, including canthus
2.6
6.6
38
152
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.4
6.6
455
3752
8720/2-C44.9
ICD-O-3
Melanoma in situ of skin, NOS
10.1
6.5
12
12
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.5
6.5
317
2445
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.5
6.5
339
2652
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.7
6.4
124
775
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.2
6.4
51
237
B35.3
ICD-10 Finland
Tinea pedis
2.5
6.4
40
167
D23.7
ICD-10 Finland
Benign neoplasm: Skin of lower limb, including hip
5.6
6.3
17
31
J01DB01
ATC
cefalexin; oral
1.5
6.3
683
6116
R22.2
ICD-10 Finland
Localized swelling, mass and lump, trunk
2.6
6.3
34
132
I78.19
ICD-10 Finland
Other nevus (non-neoplastic)
18.2
6.3
9
5
L14
ICPC
Leg/thigh symptom/complaint
1.9
6.3
82
457
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
2.8
6.3
30
109
Z3231
NOMESCO Finland
Registered nurse
1.5
6.3
226
1640
QCA50
NOMESCO Finland
Cryotherapy of skin of upper limb
+∞
6.3
6
*
R51.80
ICD-10 Finland
Headache
1.7
6.2
128
814
D22.4
ICD-10 Finland
Melanocytic naevi of scalp and neck
4.0
6.2
17
43
C02AC05
ATC
moxonidine; oral
2.2
6.1
48
221
J05AB01
ATC
aciclovir; systemic
1.5
6.1
189
1327
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.9
6.1
75
410
L71.8
ICD-10 Finland
Other rosacea
3.6
6.1
19
53
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
6.0
348
2762
L57.8
ICD-10 Finland
Other skin changes due to chronic exposure to nonionizing radiation
10.1
6.0
11
11
N39.4
ICD-10 Finland
Other specified urinary incontinence
1.8
6.0
99
592
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
6.1
6.0
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
730
6110
2.19
16.51
24.0
21.1
13.71
13.75
%
0.45
722
6029
502
3728
1.82
16.21
2.7
2.5
80.52
79.40
nmol/l
0.38
454
3309
435
3155
1.75
14.67
5.2
4.2
0.01
0.04
estimate
1.18
91
733
722
6102
2.06
14.61
9.3
8.0
76.69
79.53
u/l
1.28
685
5745
540
4253
1.71
12.76
5.6
4.1
0.00
3.88
estimate
0.80
112
902
533
4203
1.69
12.34
5.5
4.1
0.00
0.00
estimate
-0.00
112
877
541
4285
1.69
12.30
5.6
4.2
0.00
0.36
estimate
0.52
103
860
847
7805
3.86
11.98
14.6
12.4
24.13
24.61
u/l
0.37
823
7558
558
4475
1.68
11.92
10.5
9.5
3.81
4.14
e9/l
3.18
498
3883
276
1885
1.68
10.74
5.7
4.2
1.02
1.02
kg/l
1.00
195
1248
533
4293
1.62
10.55
8.8
6.7
1.22
1.22
mmol/l
0.34
465
3695
786
7061
2.14
10.46
6.7
5.6
1.98
1.95
mu/l
0.33
732
6472
681
5850
1.75
10.40
5.7
4.5
11.72
13.46
mm/h
2.61
640
5420
695
6006
1.77
10.37
5.3
4.5
14.94
14.97
pmol/l
0.11
642
5467
311
2210
1.63
10.27
4.1
3.7
0.01
0.05
estimate
0.53
96
691
836
7728
2.93
10.12
24.1
20.2
3.98
3.98
mmol/l
0.10
820
7569
485
3871
1.57
9.55
7.4
6.1
1.22
1.21
mmol/l
0.34
454
3566
833
7716
2.74
9.48
23.8
20.1
139.76
139.67
mmol/l
0.52
817
7568
845
7885
3.23
9.47
26.5
22.4
81.97
77.00
umol/l
2.57
832
7791
852
7991
3.75
9.41
30.5
25.6
243.57
249.63
e9/l
2.04
839
7816
852
7992
3.75
9.39
30.4
25.5
91.62
91.45
fl
0.50
845
7895
852
7993
3.74
9.36
30.5
25.5
4.42
4.42
e12/l
0.09
838
7792
852
7993
3.74
9.36
30.9
26.0
39.90
39.73
%
0.39
845
7892
852
7995
3.73
9.32
30.7
25.7
133.83
132.93
g/l
1.17
846
7897
784
7142
1.96
8.40
7.5
6.8
38.80
39.71
mmol/mol
3.28
741
6621
463
3721
1.52
8.39
6.1
4.6
36.17
35.33
g/l
2.79
429
3474
798
7324
2.04
8.21
6.2
5.5
5.79
5.98
mmol/l
6.05
734
6653
804
7400
2.09
8.19
19.2
16.4
23.59
24.75
mg/l
0.45
663
6135
30
93
3.31
8.13
1.6
1.4
—
—
—
0
0
800
7353
2.05
8.13
6.1
5.3
4.57
4.63
mmol/l
1.10
749
6779
811
7496
2.15
8.04
7.0
6.2
2.61
2.66
mmol/l
0.93
752
6877
381
2966
1.50
7.87
3.6
3.5
2.35
2.36
mmol/l
0.78
342
2685
611
5268
1.53
7.52
6.3
5.0
2332.52
2423.91
e6/l
0.01
13
87
36
132
2.80
7.36
10.0
4.8
118.89
564.94
iu/ml
—
9
18
317
2403
1.50
7.31
5.9
4.0
0.00
0.01
estimate
0.96
104
809
336
2596
1.48
6.97
3.3
2.5
59.49
63.88
u/l
0.68
304
2386
513
4320
1.45
6.68
6.9
6.5
11.91
11.40
umol/l
0.61
488
4119
790
7310
1.85
6.68
5.8
5.2
1.56
1.51
mmol/l
2.53
731
6687
115
698
1.75
6.64
4.4
3.2
101.38
84.27
ng/l
0.95
103
602
84
468
1.88
6.43
1.2
1.2
119.83
164.10
u/ml
0.65
79
426
402
3261
1.43
6.25
2.0
1.9
1.22
1.32
mmol/l
2.58
326
2707
469
3921
1.42
6.12
17.1
15.5
1.25
1.27
inr
0.28
399
3223
161
1096
1.58
5.94
7.7
4.5
1.03
1.03
mmol/l
0.14
151
1004
55
273
2.08
5.85
1.4
1.2
0.55
1.68
u/ml
—
6
17
431
3578
1.40
5.70
3.5
2.9
109.64
123.95
ug/l
1.02
395
3281
249
1883
1.45
5.52
4.0
2.5
5.47
6.19
e6/l
0.33
232
1732
198
1435
1.49
5.45
1.4
1.3
36.33
33.54
iu/ml
0.09
65
468
45
213
2.17
5.42
4.0
2.9
1.78
1.59
mg/l
0.53
35
187
324
2582
1.41
5.34
2.6
2.1
176.27
233.67
u/l
0.74
302
2450
756
6998
1.60
5.28
5.0
4.4
1.18
1.27
mmol/l
4.22
692
6334
56
1008
0.53
5.27
5.5
5.2
33.88
33.18
%
0.17
40
636
99
626
1.66
4.92
3.0
2.7
62.27
63.61
ml/min/173m2
0.13
49
274
229
1738
1.43
4.91
1.3
1.3
1.88
1.62
u/ml
0.08
69
454
474
4063
1.36
4.85
2.9
2.6
—
—
—
0
0
259
2015
1.41
4.81
4.3
2.7
334.63
342.64
umol/l
0.64
230
1750
136
938
1.53
4.70
2.5
2.5
7.04
7.70
umol/l
0.26
119
820
25
97
2.62
4.67
1.0
1.1
1.44
1.55
g/l
0.89
25
89
290
2324
1.37
4.45
4.6
3.2
0.32
0.49
e6/l
1.08
227
1704
539
4749
1.35
4.43
5.8
4.9
6.45
6.70
mmol/l
2.97
521
4519
319
2599
1.36
4.40
3.8
3.2
30.32
32.54
u/l
0.61
302
2454
161
1171
1.46
4.29
1.6
1.4
—
—
—
0
0
72
436
1.71
4.23
1.3
1.3
19.32
48.14
au/ml
—
5
35
329
2707
1.35
4.21
5.1
3.2
16.57
78.68
e6/l
1.87
270
2080
217
1674
1.39
4.16
4.1
4.1
198.11
377.66
ng/l
0.99
181
1363
185
1399
1.41
3.97
4.4
3.0
0.82
0.82
mmol/l
0.44
174
1323
166
1234
1.43
3.92
2.0
1.9
30.32
29.33
s
1.02
160
1200
110
760
1.51
3.77
2.8
2.0
411.49
388.37
nmol/l
0.48
105
704
145
1060
1.44
3.74
2.0
1.8
—
—
—
0
0
102
695
1.53
3.73
4.2
3.2
173.76
213.56
ng/l
0.76
91
644
25
111
2.29
3.57
1.7
1.3
197.78
162.09
au/ml
—
9
33
76
489
1.61
3.57
2.7
2.5
48.35
20.96
au/ml
—
6
31
7
9
7.83
3.56
3.4
1.4
—
—
—
0
0
75
482
1.61
3.54
1.3
1.2
76.03
136.98
u/ml
1.40
28
191
225
1790
1.35
3.50
3.0
2.9
2.46
2.46
mmol/l
0.28
201
1626
191
1487
1.36
3.41
1.8
1.5
2.41
2.53
g/l
0.34
125
867
48
276
1.78
3.41
1.8
1.6
7.62
13.74
u/ml
0.87
12
57
148
1118
1.39
3.17
2.0
1.8
—
—
—
0
0
26
124
2.13
3.17
1.7
1.3
—
—
—
0
0
104
740
1.46
3.10
3.6
3.1
65.84
66.87
g/l
0.79
97
674
24
114
2.14
2.96
1.7
1.2
287.27
258.47
u/ml
0.16
15
58
126
937
1.40
2.96
9.8
6.7
—
—
—
0
0
17
70
2.46
2.89
1.2
1.3
—
—
—
0
0
15
58
2.61
2.88
1.5
1.8
102.61
92.55
ng/l
0.19
15
58
35
195
1.83
2.79
1.7
1.5
—
—
—
0
0
24
118
2.06
2.73
1.7
1.4
—
—
—
0
0
337
2909
1.26
2.72
3.7
3.3
6.74
7.00
mmol/l
0.60
288
2431
30
162
1.88
2.65
1.2
1.3
272.00
222.10
miu/ml
0.27
13
77
427
3802
1.24
2.58
2.4
2.2
100.22
95.28
pmol/l
1.31
210
1916
16
68
2.38
2.57
1.3
1.2
—
—
—
0
0
528
4818
1.24
2.52
3.4
3.3
45.74
48.78
u/l
0.34
488
4490
169
1350
1.31
2.51
1.4
1.3
15.39
14.20
u/ml
0.06
71
492
13
51
2.57
2.45
2.4
2.6
33.46
25.58
mg/l
0.20
13
36
36
212
1.73
2.43
3.1
3.1
2.59
2.04
index
0.23
17
115
5
8
6.28
2.37
1.0
1.1
14.52
6.59
pmol/l
—
5
8
98
727
1.39
2.36
3.4
3.6
1.23
1.23
mmol/l
0.35
82
625
331
2891
1.23
2.33
4.4
4.0
9.91
7.81
mg/mmol
0.33
190
1719
21
106
2.01
2.27
2.0
1.9
6277.55
3648.19
u/l
—
8
42
178
1452
1.28
2.25
4.3
2.9
0.68
1.12
e6/l
3.01
109
763
82
595
1.42
2.25
1.7
1.5
—
—
—
0
0
55
369
1.52
2.23
1.9
1.9
1.44
1.53
g/l
0.28
47
332
36
218
1.68
2.22
1.2
1.1
—
—
—
0
0
294
2555
1.23
2.13
1.7
1.7
24.88
20.59
nmol/l
1.94
251
2111
176
1447
1.27
2.09
2.0
1.8
—
—
—
0
0
208
1746
1.25
2.07
1.8
1.7
1.24
1.36
mg/l
0.17
159
1361
65
460
1.45
2.05
2.7
3.3
4.42
4.48
pmol/l
0.16
55
411
362
3222
1.21
2.05
4.1
4.0
34.45
62.85
ng/l
0.79
261
2423
91
685
1.37
2.03
2.0
2.5
8.34
7.15
ug/l
0.21
79
608
753
7228
1.30
1.97
19.0
16.6
73.89
76.45
ml/min/173m2
3.04
704
6731
35
218
1.63
1.97
1.2
1.1
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
7
21
3.35
1.97
1.3
2.6
138.00
128.48
%
—
7
21
44
294
1.52
1.86
1.7
1.6
14.40
9.22
iu/ml
—
9
66
11
46
2.41
1.85
1.8
1.6
13.05
4.46
umol/l
—
6
29
253
2196
1.21
1.82
2.6
2.2
2.67
2.91
mg/l
0.99
218
1867
7
23
3.06
1.80
1.9
1.6
0.59
0.62
mmol/l
—
7
23
125
1004
1.29
1.80
6.8
7.2
4.95
5.09
kpa
0.92
116
966
125
1004
1.29
1.80
6.8
7.1
12.01
11.98
kpa
0.02
116
968
224
1927
1.22
1.76
6.9
5.9
2.62
3.08
ug/l
0.32
197
1722
122
986
1.28
1.68
6.9
7.2
1.39
1.02
mmol/l
0.61
92
819
42
285
1.50
1.67
2.8
3.0
—
—
—
0
0
11
49
2.26
1.64
1.5
1.2
—
—
—
0
0
110
882
1.28
1.62
3.8
3.4
—
—
—
0
0
15
77
1.96
1.60
3.0
2.5
1053.80
842.88
mg
0.17
15
77
30
191
1.59
1.59
2.0
1.4
—
—
—
0
0
7
26
2.71
1.58
1.0
1.1
—
—
—
0
0
31
202
1.55
1.50
1.7
1.6
—
—
—
0
0
80
622
1.32
1.49
1.7
1.5
—
—
—
0
0
96
768
1.28
1.45
3.3
2.5
37.99
37.12
u/l
0.07
77
635
62
466
1.36
1.45
4.3
3.6
48.62
47.52
%
0.15
62
456
128
1063
1.24
1.42
1.7
1.4
—
—
—
0
0
26
165
1.59
1.41
1.0
1.2
10.57
48.83
e6/l
0.53
21
124
9
40
2.26
1.40
4.1
1.8
—
—
—
0
0
170
1968
0.83
1.38
2.5
2.3
—
—
—
0
0
206
1814
1.18
1.25
1.9
1.8
212651036.92
21974757.02
pmol/l
1.12
166
1479
8
36
2.23
1.24
1.3
1.1
—
—
—
0
0
8
36
2.23
1.24
2.3
2.6
823.25
1094.78
u/ml
—
8
36
17
100
1.71
1.24
3.4
6.0
11.89
12.52
mg/l
0.26
17
94
45
331
1.38
1.23
1.3
2.1
35.58
39.90
u/l
0.70
37
295
5
19
2.64
1.21
1.0
1.2
—
—
—
0
0
397
3680
1.14
1.20
2.9
2.7
—
—
estimate
—
0
0
156
1346
1.19
1.19
4.6
3.0
1.97
2.82
e6/l
1.25
86
653
10
50
2.01
1.16
2.4
2.1
13.30
13.32
%
—
10
50
0
34
0.00
1.16
0.0
1.1
—
—
—
0
0
0
34
0.00
1.16
0.0
1.1
—
—
—
0
0
171
1492
1.18
1.16
1.8
1.7
1231.68
1194.89
nmol/l
0.19
132
1123
5
20
2.51
1.15
1.4
1.0
—
—
—
0
0
163
1418
1.18
1.14
3.6
2.4
12.48
12.27
umol/l
0.15
149
1318
32
225
1.44
1.13
3.8
3.8
3.84
3.92
mmol/l
0.37
32
220
54
416
1.32
1.12
4.7
2.9
25.41
25.41
mmol/l
0.00
54
401
177
1555
1.17
1.10
6.5
4.8
23.16
21.72
%
0.79
100
803
7
31
2.27
1.10
3.1
1.2
—
—
—
0
0
5
21
2.39
1.09
1.4
1.7
15.44
15.07
pmol/l
—
5
15
7
32
2.20
1.08
1.6
1.0
2070.43
1496.09
miu/ml
—
7
32
153
1331
1.18
1.08
3.5
2.4
2.38
2.30
g/l
0.98
139
1233
30
211
1.44
1.07
1.3
1.2
2.32
14.14
u/ml
—
5
36
40
298
1.36
1.04
5.2
4.0
63.33
70.68
mg/l
0.10
35
256
40
299
1.35
1.02
5.2
4.0
47.74
61.64
mg/l
0.27
35
258
45
344
1.32
1.00
1.6
1.3
—
—
—
0
0
19
123
1.56
1.00
1.2
1.3
—
—
—
0
0
22
150
1.48
0.93
1.0
1.1
0.73
0.69
ratio
—
6
27
11
63
1.76
0.90
1.2
1.0
—
—
—
0
0
56
449
1.26
0.90
4.8
3.9
1.02
1.02
ratio
1.31
50
420
11
64
1.73
0.86
1.1
1.1
—
110.00
—
0
9
8
44
1.83
0.86
2.1
1.7
12.13
12.75
umol/l
—
8
37
8
45
1.78
0.84
4.9
2.6
0.63
0.84
index
—
8
45
34
258
1.33
0.82
1.5
1.5
258.32
274.41
ug/g
0.22
22
163
36
276
1.32
0.82
5.1
3.7
1.77
4.03
ratio
0.93
18
160
52
419
1.26
0.81
1.5
1.5
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
33
250
1.33
0.81
6.0
2.9
0.34
0.40
iu/ml
0.44
17
134
298
2770
1.12
0.80
3.2
3.2
1373.13
1297.68
ng/l
0.13
252
2400
24
173
1.40
0.79
1.3
1.2
0.88
0.92
g/l
0.27
24
173
16
106
1.52
0.79
2.4
1.6
—
—
—
0
0
54
440
1.24
0.78
1.8
1.8
3.44
3.47
mmol/l
0.08
41
321
52
422
1.25
0.77
2.9
1.9
—
—
—
0
0
18
124
1.46
0.75
1.8
1.9
52.72
43.09
nmol/l
0.47
18
116
5
24
2.09
0.74
1.6
1.2
0.36
0.29
g/l
—
5
18
101
879
1.17
0.74
4.0
3.1
1.62
1.96
mmol/l
0.40
94
757
9
55
1.64
0.73
1.1
1.2
—
—
—
0
0
32
247
1.31
0.71
1.3
1.3
—
—
—
0
0
26
195
1.34
0.70
2.0
1.9
—
—
—
0
0
10
61
1.65
0.68
1.4
1.6
—
—
—
0
0
5
27
1.86
0.68
1.6
1.1
8.17
8.82
ug/l
—
5
27
7
42
1.67
0.68
5.7
4.5
1.43
1.38
%
—
7
42
42
339
1.25
0.67
1.1
1.0
—
—
—
0
0
7
43
1.63
0.67
1.0
1.5
82.63
58.66
ug/l
—
7
43
25
188
1.34
0.67
1.4
1.3
—
—
—
0
0
31
241
1.30
0.66
2.0
1.9
—
—
—
0
0
31
241
1.30
0.66
1.5
1.7
2.43
4.11
mg/l
0.90
17
187
137
1231
1.13
0.66
3.6
2.3
21.99
21.58
%
0.14
124
1150
5
28
1.79
0.66
1.6
1.2
197.60
170.69
pmol/l
—
5
28
27
206
1.32
0.66
2.1
1.5
—
—
—
0
0
19
137
1.40
0.65
2.3
1.7
—
—
—
0
0
17
120
1.42
0.65
1.5
1.3
0.67
15.44
nmol/l
0.50
17
115
5
29
1.73
0.64
1.0
1.0
—
—
—
0
0
103
912
1.15
0.62
4.0
3.1
5.76
5.77
kpa
0.04
103
886
6
101
0.59
0.62
1.0
2.2
—
24.11
—
0
38
29
226
1.29
0.62
1.7
1.7
7447.16
13673.91
e6/l
0.55
19
160
10
63
1.59
0.62
1.3
1.2
—
—
—
0
0
35
280
1.26
0.62
1.7
2.3
0.07
0.03
g/l
0.23
29
249
34
272
1.26
0.60
1.5
2.3
0.06
0.00
g/l
0.49
27
238
87
764
1.15
0.60
3.4
2.8
4.54
4.40
kpa
0.18
87
743
40
327
1.23
0.59
1.7
2.5
0.24
1.23
g/l
2.60
33
278
10
64
1.57
0.58
1.3
1.2
—
—
—
0
0
10
64
1.57
0.58
1.3
1.2
—
—
—
0
0
61
709
0.85
0.57
1.9
1.7
1.43
1.53
%
0.79
54
598
23
176
1.32
0.57
1.1
1.1
—
3.86
—
0
16
20
263
0.75
0.56
1.6
1.7
—
—
—
0
0
11
73
1.51
0.56
1.9
2.3
—
—
—
0
0
31
248
1.26
0.56
1.4
1.2
—
—
—
0
0
22
284
0.77
0.55
1.7
1.8
—
—
—
0
0
9
61
1.48
0.54
1.3
1.2
—
—
—
0
0
15
108
1.40
0.53
2.4
1.5
—
—
—
0
0
21
161
1.31
0.52
1.1
1.2
1.49
1.58
g/l
1.17
21
161
46
389
1.19
0.51
3.0
1.8
—
—
—
0
0
11
75
1.47
0.51
1.0
1.1
—
—
—
0
0
36
431
0.83
0.49
3.3
3.3
1.84
2.05
mmol/l
0.16
26
324
29
235
1.24
0.48
1.2
1.2
—
—
—
0
0
20
156
1.29
0.45
2.3
1.4
—
—
—
0
0
5
32
1.57
0.42
1.0
1.5
—
—
—
0
0
23
185
1.25
0.42
1.5
1.3
—
—
—
0
0
10
70
1.43
0.42
1.3
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
45.57
—
0
15
26
213
1.23
0.41
2.3
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
2.1
—
7.91
—
0
11
15
114
1.32
0.41
1.1
1.1
—
18.91
—
0
26
23
186
1.24
0.40
2.3
1.4
—
—
—
0
0
10
71
1.41
0.39
1.2
1.3
—
—
—
0
0
10
72
1.39
0.37
1.3
1.2
41.70
49.63
u/l
—
10
63
9
70
1.29
0.36
2.2
1.4
—
—
—
0
0
28
235
1.20
0.36
1.6
1.4
—
—
—
0
0
5
77
0.65
0.36
1.0
1.3
7.86
7.14
mmol/l
—
5
63
10
73
1.37
0.34
1.3
1.2
—
—
—
0
0
10
73
1.37
0.34
1.3
1.1
107.30
102.82
pmol/l
—
10
73
6
44
1.37
0.34
1.0
1.0
—
—
—
0
0
6
45
1.34
0.34
1.3
1.2
15.83
19.03
u/l
—
6
37
10
74
1.36
0.32
3.5
1.6
—
—
—
0
0
22
184
1.20
0.30
2.4
3.5
17.19
27.06
mg/l
1.06
15
124
25
212
1.18
0.30
1.6
2.2
9.91
12.26
mg/l
0.81
25
197
56
508
1.11
0.28
2.9
3.2
23.97
24.36
mmol/l
0.40
56
501
10
76
1.32
0.28
1.1
1.1
—
—
—
0
0
60
549
1.10
0.26
9.0
9.0
94.53
93.97
%
0.62
60
543
5
72
0.69
0.26
2.2
2.1
1.20
2.38
u/field
—
5
34
25
217
1.16
0.24
2.4
1.8
2.46
4.05
iu/l
—
9
80
25
218
1.15
0.23
1.6
1.5
0.07
0.08
iu/ml
—
7
46
5
39
1.28
0.23
3.8
1.5
—
—
—
0
0
5
40
1.25
0.22
3.8
1.6
—
—
—
0
0
5
40
1.25
0.22
3.8
1.6
—
—
—
0
0
209
2016
1.05
0.22
4.8
4.0
87.44
89.31
%
0.49
203
1977
27
238
1.14
0.22
1.6
1.6
—
—
—
0
0
64
595
1.08
0.21
2.2
2.0
3.18
3.35
ratio
0.58
50
475
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
1.19
—
0
12
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
20
173
1.16
0.21
3.4
2.3
72.60
54.74
ug/min
0.17
15
97
6
48
1.25
0.20
1.3
1.2
52.17
91.60
u/l
—
6
40
6
49
1.23
0.20
1.8
1.7
—
—
—
0
0
6
51
1.18
0.19
1.3
1.9
—
—
—
0
0
18
156
1.16
0.18
1.2
1.6
287.94
300.16
mu/l
0.11
18
140
17
147
1.16
0.18
1.4
1.3
—
—
—
0
0
17
147
1.16
0.18
1.4
1.3
—
—
—
0
0
18
157
1.15
0.17
1.6
1.4
—
—
—
0
0
57
534
1.07
0.17
1.7
1.6
—
—
—
0
0
9
78
1.16
0.15
1.6
1.6
—
—
—
0
0
21
232
0.90
0.13
1.2
1.3
—
—
—
0
0
25
270
0.92
0.10
1.6
1.5
0.29
0.30
mg/l
0.02
13
113
56
535
1.05
0.10
9.5
9.1
0.64
0.65
%
0.07
56
529
5
46
1.09
0.09
1.4
1.1
—
—
—
0
0
11
97
1.14
0.09
1.0
1.1
—
—
—
0
0
20
185
1.08
0.08
2.2
1.6
—
—
—
0
0
7
66
1.06
0.08
1.3
1.6
—
—
—
0
0
8
94
0.85
0.06
1.1
1.1
—
1.83
—
0
14
14
130
1.08
0.04
1.4
1.4
—
—
—
0
0
114
1154
0.99
0.03
3.6
3.3
0.80
0.79
ug/l
0.05
76
781
95
938
1.01
0.02
3.3
4.2
4.05
23.60
ug/l
1.56
81
769
18
187
0.96
0.01
2.7
1.6
—
—
—
0
0
11
108
1.02
0.00
1.2
1.2
—
—
—
0
0
12
119
1.01
0.00
1.4
1.6
1198.03
895.09
mu/l
—
7
105
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
7
72
0.97
0.00
1.0
1.1
81.43
98.24
%
—
7
66
0
8
0.00
0.00
0.0
1.4
—
6.25
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
-0.00
1.2
1.5
—
—
—
0
0
5
49
1.02
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
52.71
—
0
7
5
49
1.02
-0.00
1.0
1.2
—
—
—
0
0
5
56
0.89
-0.00
3.2
1.4
—
52.86
—
0
7
9
98
0.92
-0.00
3.0
3.5
—
—
—
0
0
6
62
0.97
-0.00
1.2
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
7
71
0.99
-0.00
1.7
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
94
0.96
-0.00
1.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
-0.00
1.2
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_OTHERMELANIN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHERMELANIN | 0.735 [0.65, 0.83] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.778 |
During the follow-up period (1.1.1998 — 31.12.2019), 526 out of 3068 females with L12_OTHERMELANIN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHERMELANIN | 0.759 [0.63, 0.92] | 0.005 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 253 out of 1356 males with L12_OTHERMELANIN died.
Mortality risk
Mortality risk for people of age
years, who have L12_OTHERMELANIN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.1% | 0.146% |
| 5 | 0.531% | 0.976% |
| 10 | 1.325% | 2.501% |
| 15 | 2.461% | 4.56% |
| 20 | 4.247% | 7.678% |
Relationships between endpoints
↥Index endpoint: L12_OTHERMELANIN – Other melanin hyperpigmentation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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