Other disorders of pigmentation

L12_OTHPIGMENTATION

obsolete_incontinentia pigmenti achromians: a dermal melanocytic condition affecting the shoulder area. Nevus of Ito often occurs in association with nevus of Ota in the same patient but is much less common, although the true incidence is unknown.

Suggest a new description

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L81
  • Cause of death: ICD-10 L81

2 out of 7 registries used, show all original rules.

1692

4. Check minimum number of events

None

1692

5. Include endpoints

1726

6. Filter based on genotype QC (FinnGen only)

1640

Control definitions (FinnGen only)

Control exclude
L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L80-L99
Name in latin
Aliae perturbationes pigmentationis cutis

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: unknown.

No upset table: unknown.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 11936 7478 4395
Only index persons 10675 6915 3760
Unadjusted period prevalence (%)
Whole population 0.18 0.21 0.12
Only index persons 0.22 0.25 0.14
Median age at first event (years)
Whole population 54.72 57.66 49.93
Only index persons 57.01 58.69 53.92

-FinnGen-

Key figures

All Female Male
Number of individuals 1640 1086 554
Unadjusted period prevalence (%) 0.34 0.39 0.25
Median age at first event (years) 60.47 58.87 63.60

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1725
Matched controls
17250
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L81.1
ICD-10 Finland
Chloasma
154.7
312.0
155
11
L81.7
ICD-10 Finland
Pigmented purpuric dermatosis
766.8
307.7
365
6
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
12.6
307.7
600
699
L81.4
ICD-10 Finland
Other melanin hyperpigmentation
899.5
307.7
811
17
L57.0
ICD-10 Finland
Actinic keratosis
5.9
207.2
451
973
L81.9
ICD-10 Finland
Disorder of pigmentation, unspecified
271.6
147.8
149
6
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
10.8
131.7
147
147
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
5.6
123.5
259
527
L81.8
ICD-10 Finland
Other specified disorders of pigmentation
330.6
121.9
122
*
XQ848
NOMESCO Finland
Dermatological photography
9.6
119.5
146
165
XQ845
NOMESCO Finland
Dermatoscopy
11.8
104.7
109
98
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
23.4
101.9
74
33
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
7.9
86.0
122
165
L82
ICD-10 Finland
Seborrhoeic keratosis
3.1
83.6
440
1709
ZXC50
NOMESCO Finland
Cryotherapy
7.1
80.1
125
188
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
3.9
79.6
261
749
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
7.9
77.0
108
144
R23.8
ICD-10 Finland
Other and unspecified skin changes
2.8
71.1
475
2080
D03.31
ICD-10 Finland
Melanoma in situ in another or unspecified part of the face
28.2
64.9
44
16
L81.0
ICD-10 Finland
Postinflammatory hyperpigmentation
608.7
60.1
59
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.6
58.7
445
2051
E0000UV, ,
ATC
2.1
47.1
800
5070
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
18.0
45.6
37
21
L81.3
ICD-10 Finland
Café au lait spots
+∞
45.0
43
*
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
5.7
42.9
81
147
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
3.3
42.8
175
572
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
6.6
42.4
69
108
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
15.1
41.7
37
25
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
8.9
41.5
52
60
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
3.2
41.4
173
573
D07AC01
ATC
betamethasone; topical
2.0
40.4
673
4173
D06BB10
ATC
imiquimod; topical
3.5
39.4
141
423
TQW99
NOMESCO Finland
Other minor procedure on skin
3.6
38.2
132
387
127
Kela drug reimbursment
Transplant complication
8.4
36.1
47
57
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
5.0
35.8
79
165
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
4.6
35.5
86
194
TQW80
NOMESCO Finland
Local dermatologic skincare
5.5
34.2
67
126
ZXC15
NOMESCO Finland
Use of photodynamic technique
7.0
34.0
52
76
L04AA06
ATC
mycophenolic acid; systemic
7.0
32.8
50
73
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
3.4
32.1
121
375
QXE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in uspecified region
9.9
31.3
36
37
S18
ICPC
Laceration/cut
1.8
29.9
813
5740
D07AD01
ATC
clobetasol; topical
2.2
29.7
310
1594
Z94.0
ICD-10 Finland
Kidney transplant status
10.2
28.3
32
32
L04AA01
ATC
[U] ciclosporin
6.5
28.2
46
72
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
3.0
28.1
129
450
D07AB02
ATC
hydrocortisone butyrate; topical
1.8
27.1
530
3371
SPAT1153
SPAT
Removal of sutures
1.8
25.3
572
3783
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
7.6
24.7
35
47
L04AD01
ATC
ciclosporin; systemic
5.1
24.5
52
105
S29
ICPC
Skin symptom/complaint other
1.9
24.3
354
2039
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
3.9
24.3
73
194
QXA50
NOMESCO Finland
Skin cryotherapy, unspecified location
9.5
23.6
28
30
D69.0
ICD-10 Finland
Allergic purpura
9.2
23.0
28
31
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
22.8
412
2537
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
22.7
520
3430
S08
ICPC
Skin colour change
2.8
22.2
119
451
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
9.1
22.1
27
30
D22.7
ICD-10 Finland
Melanocytic naevi of lower limb, including hip
4.8
21.8
49
104
D23.3
ICD-10 Finland
Benign neoplasm: Skin of other and unspecified parts of face
3.7
21.7
69
191
J01DB01
ATC
cefalexin; oral
1.8
20.7
1393
12041
ZXC20
NOMESCO Finland
Use of chemical agents
4.2
20.4
55
135
D07AB08
ATC
desonide; topical
2.2
20.3
196
970
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
3.6
20.2
68
196
C44.71
ICD-10 Finland
Basocellular carcinoma of the skin of the lower extremity including the hip
6.5
20.1
33
52
L91.0
ICD-10 Finland
Hypertrophic scar
19.1
20.0
30
16
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.8
19.8
99
362
E000006, ,
ATC
2.5
19.7
133
565
S21
ICPC
Skin texture symptom/complaint
1.9
19.3
258
1436
UJF32
NOMESCO Finland
Coloscopy
1.7
18.8
452
2996
L81.2
ICD-10 Finland
Freckles
+∞
18.8
18
*
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
4.9
18.8
41
85
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
18.6
609
4362
D22.3
ICD-10 Finland
Melanocytic naevi of other and unspecified parts of face
3.8
18.6
57
154
A02BC05
ATC
esomeprazole; systemic
1.6
18.6
694
5131
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
18.4
388
2480
E000001, ,
ATC
1.8
18.1
340
2101
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
2.5
18.0
121
513
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
18.0
232
1275
H02AB06
ATC
prednisolone; systemic
1.6
18.0
790
6049
L04AX01
ATC
azathioprine; systemic
2.9
17.4
81
285
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
4.5
17.3
42
95
SPAT1301
SPAT
No procedures
1.6
16.9
532
3757
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
16.9
596
4325
M79.6
ICD-10 Finland
Pain in limb
1.5
16.6
701
5289
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
40.5
16.3
20
5
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
16.1
203
1106
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
5.6
16.0
30
54
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
16.0
458
3153
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
15.8
757
5853
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
15.8
743
5723
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.4
15.7
39
90
D02AX
ATC
Other emollients and protectives
3.1
15.3
66
222
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
16.2
15.2
24
15
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
3.1
15.1
62
203
A12AA04
ATC
calcium carbonate; oral
5.2
15.1
31
61
D06BX02
ATC
ingenol mebutate; topical
4.7
15.0
34
73
M25.5
ICD-10 Finland
Pain in joint
1.6
14.7
524
3784
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.6
14.2
372
2496
SAA03
NOMESCO Finland
Extended examination of mouth
1.5
14.0
633
4800
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
13.9
467
3320
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
12.8
13.9
24
19
A02BC03
ATC
lansoprazole; oral
1.5
13.8
478
3423
D07AC13
ATC
mometasone; topical
1.6
13.8
461
3276
N03AX12
ATC
[U] gabapentin; oral
1.7
13.5
278
1751
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.7
13.5
74
284
D02AE01
ATC
carbamide; topical
2.2
13.2
112
526
N02AX02
ATC
tramadol; systemic, rectal
1.5
13.1
679
5273
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
12.9
1153
9931
SAA02
NOMESCO Finland
Basic examination of mouth
1.5
12.9
1062
9004
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
4.4
12.9
32
74
J01MA02
ATC
ciprofloxacin; systemic
1.5
12.8
607
4630
L85.3
ICD-10 Finland
Xerosis cutis
5.8
12.7
23
40
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
3.9
12.6
37
97
D69.2
ICD-10 Finland
Other nonthrombocytopenic purpura
12.4
12.6
22
18
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
5.5
12.6
24
44
SAA01
NOMESCO Finland
Simple examination of mouth
1.5
12.5
1156
9991
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
3.7
12.5
39
107
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
10.1
12.5
24
24
P01BA02
ATC
hydroxychloroquine; oral
2.0
12.4
141
740
A02BC02
ATC
pantoprazole; systemic
1.5
12.4
1111
9539
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
12.3
294
1925
D22.6
ICD-10 Finland
Melanocytic naevi of upper limb, including shoulder
4.1
12.1
33
82
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.7
12.1
223
1361
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
12.1
462
3364
E000002, ,
ATC
1.8
12.0
175
997
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
11.9
210
1265
G44.2
ICD-10 Finland
Tension-type headache
1.7
11.9
234
1453
M54.5
ICD-10 Finland
Low back pain
1.5
11.8
576
4401
L84
ICD-10 Finland
Corns and callosities
3.1
11.8
49
162
B07.9
ICD-10 Finland
Verruca simplex
2.8
11.7
60
223
L17
ICPC
Foot/toe symptom/complaint
1.5
11.7
460
3366
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
4.6
11.7
27
59
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
3.2
11.6
45
143
ZZR00
NOMESCO Finland
Flap of skin
3.3
11.5
43
133
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.9
11.5
142
766
R60.0
ICD-10 Finland
Localized oedema
1.8
11.5
200
1201
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
3.3
11.4
42
129
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.4
11.4
77
328
A98
ICPC
Health maint/preventive medicine
2.3
11.4
1654
15688
D23.7
ICD-10 Finland
Benign neoplasm: Skin of lower limb, including hip
5.2
11.3
23
45
R03BA08
ATC
ciclesonide; inhalant
1.9
11.2
147
809
R51.80
ICD-10 Finland
Headache
1.6
11.1
255
1648
B03XA01
ATC
erythropoietin; parenteral
5.3
11.1
22
42
SPAT1263
SPAT
Sampling
1.4
11.1
669
5303
ULA02
NOMESCO Finland
Kolposcopy
1.9
11.1
136
733
F16
ICPC
Eyelid symptom/complaint
2.2
10.9
88
405
N03AX16
ATC
[U] pregabalin
1.5
10.9
368
2604
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
2.8
10.8
54
198
Z3231
NOMESCO Finland
Registered nurse
1.5
10.8
424
3093
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.3
10.8
80
355
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
4.5
10.7
26
59
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.6
10.7
309
2112
L81
ICD-10 Finland
Other disorders of pigmentation
60.4
10.6
12
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.9
10.6
147
825
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
10.5
728
5893
D10AX03
ATC
azelaic acid; topical
2.1
10.5
104
520
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
3.4
10.4
36
106
B01AB05
ATC
enoxaparin; parenteral
1.5
10.4
496
3753
L81.6
ICD-10 Finland
Other disorders of diminished melanin formation
+∞
10.4
10
*
L85.89
ICD-10 Finland
Other specified epidermal thickening
+∞
10.4
10
*
L90.5
ICD-10 Finland
Scar conditions and fibrosis of skin
16.1
10.3
16
10
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.8
10.3
166
973
L30.8
ICD-10 Finland
Other specified dermatitis
2.8
10.3
51
186
Z2446
NOMESCO Finland
Social worker
2.0
10.3
108
550
L30.0
ICD-10 Finland
Nummular dermatitis
2.5
10.3
63
256
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.4
10.3
73
318
WZC00
NOMESCO Finland
Treatment plan or consultation
1.4
10.2
565
4396
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
10.1
733
5968
QAA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of head or neck
11.4
10.1
18
16
N39.4
ICD-10 Finland
Other specified urinary incontinence
1.8
10.0
158
922
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.8
10.0
146
832
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
40.3
10.0
12
*
ZXA00
NOMESCO Finland
Right side
1.5
9.9
417
3077
D04.7
ICD-10 Finland
Carcinoma in situ: Skin of lower limb, including hip
7.7
9.9
22
29
L43.8
ICD-10 Finland
Other lichen planus
3.3
9.9
36
110
8742/2-C44.9
ICD-O-3
Lentigo maligna of skin, NOS
16.8
9.9
15
9
SPAT1260
SPAT
Consultation of another employee
1.6
9.9
279
1894
ZX120
NOMESCO Finland
Intravenous
1.8
9.8
151
875
D05BB02
ATC
acitretin; oral
3.1
9.7
40
132
SPAT1325
SPAT
Vaccination
1.4
9.7
531
4115
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
3.4
9.6
34
102
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
9.5
639
5122
ZXA05
NOMESCO Finland
Left side
1.5
9.5
384
2809
ZZA00
NOMESCO Finland
Split skin graft
2.8
9.5
47
172
L50.3
ICD-10 Finland
Dermatographic urticaria
3.2
9.5
36
113
L04AX03
ATC
methotrexate; systemic
1.8
9.5
153
899
R42
ICD-10 Finland
Dizziness and giddiness
1.5
9.4
365
2649
QCA50
NOMESCO Finland
Cryotherapy of skin of upper limb
+∞
9.4
9
*
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.7
9.4
196
1236
R06AE07
ATC
cetirizine; oral
1.4
9.4
689
5605
137
Kela drug reimbursment
Uraemia requiring dialysis
8.1
9.3
20
25
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.4
9.3
669
5419
C43.52
ICD-10 Finland
Malignant melanoma on the torso: 'superficial spreading' type
4.5
9.3
22
49
QDE99
NOMESCO Finland
Other excision or repair of lesion of skin of lower limb
8.7
9.3
19
22
C44.81
ICD-10 Finland
Overall basocellular carcinoma of the skin
9.6
9.3
18
19
SFA10
NOMESCO Finland
One-surface restoration
1.4
9.2
848
7141
J05AB11
ATC
valaciclovir; oral
1.6
9.2
224
1466
Z48.0
ICD-10 Finland
Attention to surgical dressings and sutures
2.4
9.2
61
258
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.7
9.2
175
1076
SCA01
NOMESCO Finland
Preventive oral health care, short
1.4
9.2
438
3304
S97
ICPC
Chronic ulcer skin
2.1
9.1
81
389
C10AA03
ATC
pravastatin; oral
1.9
9.1
119
656
Z2221
NOMESCO Finland
Medical doctor
1.4
9.0
417
3127
R05
ICD-10 Finland
Cough
1.5
9.0
331
2374
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.4
8.8
550
4342
L70.0
ICD-10 Finland
Acne vulgaris
3.1
8.8
35
113
J02AC01
ATC
fluconazole; systemic
1.4
8.8
614
4939
L71.8
ICD-10 Finland
Other rosacea
3.4
8.8
31
93
D06BX01
ATC
metronidazole; topical
1.7
8.7
175
1091
A11CC03
ATC
alfacalcidol; systemic
2.9
8.7
39
135
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
4.3
8.7
22
52
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.0
8.7
91
465
ZXC10
NOMESCO Finland
Use of laser
2.9
8.6
39
136
SFA20
NOMESCO Finland
Two-surface restoration
1.4
8.6
891
7614
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.5
8.6
261
1798
E000007, ,
ATC
2.0
8.6
86
432
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.0
8.6
86
432
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
1.7
8.6
165
1018
D07AA02
ATC
hydrocortisone; topical
1.6
8.5
209
1370
R06AX27
ATC
desloratadine; oral
1.4
8.5
426
3235
SAA04
NOMESCO Finland
Special examination of mouth
2.0
8.5
89
454
N06AX11
ATC
mirtazapine; oral
1.4
8.5
528
4161
SPAT1312
SPAT
General health counselling
1.4
8.4
483
3755
L81.5
ICD-10 Finland
Leukoderma, not elsewhere classified
+∞
8.3
8
*
UKC02
NOMESCO Finland
Cystoscopy
1.6
8.3
224
1501
KMAK, ,
NOMESCO Finland
1.3
8.3
772
6476
L01BA01
ATC
methotrexate; systemic
2.3
8.3
62
277
XF404
NOMESCO Finland
Ambulatory ECG
1.7
8.3
139
826
C08CA05
ATC
nifedipine; systemic
2.0
8.3
93
487
ZXA10
NOMESCO Finland
Bilateral
1.5
8.2
292
2077
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
2.6
8.2
47
186
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.7
8.2
148
898
Z01.2
ICD-10 Finland
Dental examination
1.4
8.2
692
5720
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
1.8
8.1
122
701
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.8
8.1
126
731
L14
ICPC
Leg/thigh symptom/complaint
1.8
8.1
129
754
M53.1
ICD-10 Finland
Cervicobrachial syndrome
1.6
8.1
173
1096
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
3.2
8.1
31
98
K02.1
ICD-10 Finland
Caries of dentine
1.3
8.1
892
7665
C43.31
ICD-10 Finland
Malignant melanoma of another or unspecified part of the face originating in lentigo maligna
17.3
8.1
12
7
Q85.00
ICD-10 Finland
Neurofibromatosis, type 1
17.3
8.1
12
7
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.6
8.1
185
1194
-, ,
ICD-10 Finland
2.8
8.1
40
147
N05CF02
ATC
zolpidem; oral
1.5
8.0
272
1915
C03CA01
ATC
furosemide; systemic
1.4
8.0
445
3435
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
2.8
8.0
38
136
B05DB
ATC
Hypertonic solutions
10.1
8.0
15
15
L29.9
ICD-10 Finland
Pruritus, unspecified
2.5
8.0
47
188
SDA04
NOMESCO Finland
Demanding periodontal treatment
1.4
8.0
398
3015
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
4.2
8.0
21
51
P01AB01
ATC
metronidazole; oral, rectal
1.4
8.0
618
5035
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
8.0
326
2384
H29
ICPC
Ear symptom/complaint other
1.6
7.9
176
1126
Z71.8
ICD-10 Finland
Other specified counselling
1.4
7.9
461
3588
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
1.8
7.9
125
730
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
7.9
271
1914
D04.4
ICD-10 Finland
Carcinoma in situ: Skin of scalp and neck
4.7
7.9
18
39
CJB10
NOMESCO Finland
Laser discission of secondary cataract
1.7
7.8
138
832
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
7.8
382
2885
J04BA02
ATC
dapsone; oral
10.8
7.8
14
13
M79.7
ICD-10 Finland
Fibromyalgia
2.2
7.8
60
272
R03AC02
ATC
salbutamol; inhalant
1.3
7.7
862
7400
ZXD10
NOMESCO Finland
Scheduled procedure
1.4
7.7
577
4669
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.3
7.7
708
5908
N02BE01
ATC
paracetamol; systemic, rectal
1.5
7.7
1465
13661
A04
ICPC
Weakness/tiredness general
1.5
7.7
224
1528
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
6.7
7.6
18
27
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.7
7.6
147
909
J01AA04
ATC
lymecycline; systemic
1.6
7.6
189
1245
SHA04
NOMESCO Finland
Stomatognathic treatment, very demanding
3.5
7.6
25
72
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.3
7.6
837
7170
XX9XE
NOMESCO Finland
Other ultrasound examination
4.1
7.5
20
49
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.5
7.5
220
1502
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.6
7.5
159
1007
D01
ICPC
Abdominal pain/cramps general
1.6
7.5
180
1176
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
2.5
7.4
46
189
H13
ICPC
Plugged feeling ear
1.5
7.4
289
2090
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
1.6
7.4
165
1056
A01
ICPC
Pain general/multiple sites
1.7
7.4
143
883
L80
ICD-10 Finland
Vitiligo
13.4
7.4
12
9
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.6
7.4
167
1074
EMAK, ,
NOMESCO Finland
2.2
7.4
61
285
SBA00
NOMESCO Finland
Microbiological examinations
2.6
7.4
42
166
R50.9
ICD-10 Finland
Fever, unspecified
1.5
7.4
220
1508
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
3.8
7.4
22
59
QAE99
NOMESCO Finland
Other excision or repair surgery of skin and subcutaneous tissue in head and neck
2.7
7.3
39
149
7090A
ICD-9 Finland
Other disorders of skin and subcutaneous tissue, Dyschromia[CHLOASMA]
+∞
7.3
7
*
V03AE01
ATC
polystyrene sulfonate; oral
4.2
7.3
19
46
D07XC01
ATC
betamethasone; topical
1.6
7.2
169
1095
A11
ICPC
Chest pain NOS
1.7
7.2
130
788
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.5
7.2
233
1624
SPAT1249
SPAT
Treatment-related counselling outside office
1.3
7.2
597
4896
SDA01
NOMESCO Finland
Periodontal treatment, very brief
1.4
7.2
414
3209
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
2.4
7.2
48
205
J05AB01
ATC
aciclovir; systemic
1.4
7.1
332
2483
B05DA
ATC
Isotonic solutions
8.0
7.1
15
19
S19
ICPC
Skin injury other
2.2
7.1
60
283
J01DA01
ATC
[U] cefalexin
1.3
7.0
959
8425
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.6
7.0
181
1202
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
1.8
7.0
102
583
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
2.3
6.9
48
208
S82
ICPC
Naevus/mole
1.5
6.9
206
1410
L04AD02
ATC
tacrolimus; systemic
5.5
6.9
19
35
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.6
6.9
154
987
C02AC05
ATC
moxonidine; oral
2.0
6.9
74
382
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.5
6.9
253
1809
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.5
6.8
192
1298
R52.9
ICD-10 Finland
Pain, unspecified
1.6
6.8
143
902
C44.52
ICD-10 Finland
Spinocellular carcinoma of the skin on the torso
6.7
6.8
16
24
S01
ICPC
Pain/tenderness of skin
2.0
6.8
69
349
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
1.8
6.8
105
610
M03BX02
ATC
tizanidine; oral
1.3
6.8
942
8276
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
1.6
6.8
151
968
7151
FHL
Kidney transplantation
40.2
6.8
8
*
L29.0
ICD-10 Finland
Pruritus ani
3.7
6.8
21
58
L01BB01, ,
ATC
16.8
6.7
10
6
SDA03
NOMESCO Finland
Periodontal treatment
1.3
6.7
585
4819
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
1.7
6.7
113
672
L03
ICPC
Low back symptom/complaint
1.4
6.7
418
3277
SDA02
NOMESCO Finland
Periodontal treatment, brief
1.3
6.7
524
4251
S06
ICPC
Rash localized
1.9
6.7
87
479
D20
ICPC
Mouth/tongue/lip symptom/complaint
2.0
6.7
72
372
K07.65
ICD-10 Finland
Temporomandibular joint-pain-dysfunction syndrome
3.4
6.7
23
68
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
1.8
6.7
104
605
H02
ICPC
Hearing complaint
1.5
6.7
215
1496
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.7
6.7
125
766
SPAT1310
SPAT
Counselling related to known health issue
1.3
6.7
477
3818
A02BA04
ATC
nizatidine; systemic
1.7
6.7
115
689
VALMI, ,
NOMESCO Finland
1.4
6.6
356
2723
R22.2
ICD-10 Finland
Localized swelling, mass and lump, trunk
2.2
6.6
52
238
D10AF01
ATC
clindamycin; topical
2.0
6.6
67
339
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.0
6.6
73
381
S99
ICPC
Skin disease other
2.6
6.6
36
140
8720/2-C44.9
ICD-O-3
Melanoma in situ of skin, NOS
8.7
6.6
13
15
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
10.1
6.5
12
12
E000003, ,
ATC
2.0
6.5
66
334
J01FA06
ATC
roxithromycin; oral
1.3
6.5
602
4999
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.7
6.5
119
726
H02AB04
ATC
methylprednisolone; systemic
1.5
6.5
208
1448
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.8
6.5
87
485
J01CA04
ATC
amoxicillin; systemic
1.3
6.4
1303
12011
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
6.4
784
6751
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.4
6.4
279
2057
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.4
6.4
351
2693
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.6
6.4
133
838
R23.3
ICD-10 Finland
Spontaneous ecchymoses
2.6
6.4
35
136
N05CF01
ATC
zopiclone; oral
1.3
6.4
489
3953
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.7
6.3
121
746
J01MA14
ATC
moxifloxacin; systemic
1.6
6.3
129
809
N30.0
ICD-10 Finland
Acute cystitis
1.4
6.3
249
1804
N18.0
ICD-10 Finland
End-stage renal disease
5.5
6.3
17
31
B36.0
ICD-10 Finland
Pityriasis versicolor
3.3
6.3
23
71
M01AH05
ATC
etoricoxib; oral
1.3
6.3
937
8272
QBA50
NOMESCO Finland
Cryotherapy of skin of trunk
18.1
6.3
9
5
4056, ,
NOMESCO Finland
18.1
6.3
9
5
R21
ICPC
Throat symptom/complaint
1.4
6.3
284
2110
70901
ICD-8 Finland
Other diseases of skin, Chloasma symptomaticum aliud sive NUD
+∞
6.3
6
*
L08.9
ICD-10 Finland
Local infection of skin and subcutaneous tissue, unspecified
2.3
6.2
45
199
Q85.09
ICD-10 Finland
Unspecified neurofibromatosis
26.8
6.2
8
*
M05BA07
ATC
risedronic acid; oral
2.2
6.2
52
245
UGC12
NOMESCO Finland
Flexible bronchoscopy
1.7
6.2
108
650
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
1.7
6.2
101
597
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.6
6.2
138
886
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
2.1
6.1
55
266
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
2.1
6.1
52
246
R4180
NOMESCO Finland
Podiatric therapy
3.4
6.1
21
62
SBA10
NOMESCO Finland
Measurement of salivary flow rate
3.3
6.1
22
67
Q61.3
ICD-10 Finland
Polycystic kidney, unspecified
7.7
6.1
13
17
TK800
NOMESCO Finland
Hemodialysis
3.0
6.1
26
88
B35.3
ICD-10 Finland
Tinea pedis
2.1
6.1
57
280
H25.1
ICD-10 Finland
Senile nuclear cataract
1.3
6.1
412
3264
A02BC01
ATC
omeprazole; systemic
1.3
6.1
401
3164
SPAT1043
SPAT
Audiometry
1.6
6.1
161
1074
D11
ICPC
Diarrhoea
1.5
6.1
170
1148
C43.39
ICD-10 Finland
Malignant melanoma of another or unspecified part of the face other or unspecified histology
12.6
6.1
10
8
C08CA02
ATC
felodipine; oral
1.6
6.1
141
913
B35.1
ICD-10 Finland
Tinea unguium
1.8
6.1
90
517
A03FA02
ATC
cisapride; oral, rectal
1.7
6.1
114
700
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
1.7
6.1
116
716
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
8.6
6.1
12
14
R01AD58
ATC
fluticasone, combinations; nasal
1.4
6.0
341
2627
DAB00
NOMESCO Finland
Excision of lesion of auricle
3.6
6.0
19
53
R03DC03
ATC
montelukast; oral
1.4
6.0
242
1758
H26.4
ICD-10 Finland
After-cataract
1.6
6.0
155
1028
L04AA13
ATC
[U] leflunomide
2.3
6.0
41
177
WX704
NOMESCO Finland
Intubation
1.7
6.0
117
725

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
218
518
4.67
85.62
1.3
1.2
—
—
—
0
0
963
6574
2.05
45.73
8.3
5.9
—
—
—
0
0
1004
6979
2.05
45.09
7.8
5.5
0.58
0.58
e9/l
0.12
901
5995
1004
6990
2.04
44.76
7.8
5.5
0.04
0.04
e9/l
1.01
901
6003
1018
7170
2.02
43.36
7.8
5.5
1.85
1.96
e9/l
1.48
935
6307
1026
7258
2.02
43.02
8.0
5.7
0.20
0.19
e9/l
0.85
935
6316
359
1800
2.26
37.35
1.4
1.3
610.82
556.36
titre
0.18
85
374
819
5660
1.85
33.62
2.8
2.0
—
—
—
0
0
1080
8226
1.84
31.38
11.1
8.8
3.93
4.07
e9/l
0.93
979
7162
880
6376
1.78
29.50
8.0
5.7
0.72
0.67
%
1.66
831
5936
137
489
2.96
28.65
1.3
1.2
0.41
1.09
u/ml
0.82
16
45
1337
11049
1.93
28.22
9.0
7.2
77.62
78.59
u/l
0.38
1269
10366
899
6619
1.75
27.91
8.4
6.0
8.83
8.57
%
1.64
852
6184
895
6585
1.75
27.82
8.1
5.6
2.99
2.83
%
1.33
850
6141
916
6800
1.74
27.44
8.1
5.7
27.68
28.16
%
0.72
868
6370
827
5990
1.73
26.86
2.6
2.3
79.80
78.26
nmol/l
0.82
754
5354
902
6693
1.73
26.83
7.9
5.5
57.08
56.96
%
0.11
856
6263
1289
10596
1.86
26.75
5.5
4.0
12.17
12.39
mm/h
0.21
1211
9765
628
4239
1.76
25.99
5.3
3.7
7.39
7.40
ph
0.93
103
809
113
387
3.05
25.39
1.5
1.5
1.15
1.20
g/l
1.08
104
361
930
7104
1.67
23.60
7.8
6.4
1.22
1.22
mmol/l
0.50
809
6012
862
6483
1.66
23.02
6.5
5.8
1.22
1.22
mmol/l
0.68
800
5880
822
6114
1.66
22.87
5.4
4.5
35.93
35.55
g/l
1.23
768
5671
912
7074
1.61
20.63
4.8
3.7
0.01
0.00
estimate
0.06
170
1263
904
7003
1.61
20.51
4.8
3.7
0.00
0.00
estimate
0.75
185
1385
1418
12340
1.84
20.40
22.2
16.3
14.76
14.95
%
0.63
1395
12114
902
7003
1.60
20.13
6.2
5.0
0.00
0.00
estimate
0.50
177
1295
310
1811
1.87
20.06
6.6
4.7
1.05
1.04
mmol/l
0.05
291
1665
282
1602
1.91
19.88
1.6
1.4
—
—
—
0
0
945
7466
1.59
19.22
6.6
6.1
10.89
11.65
umol/l
1.79
898
7070
99
373
2.75
18.70
1.5
1.5
0.23
0.24
g/l
0.37
87
349
745
5609
1.58
18.36
4.2
3.4
6.06
5.82
ph
0.94
44
397
837
6479
1.57
18.23
16.3
14.9
1.22
1.26
inr
0.58
258
1874
1607
14738
2.32
17.91
20.3
15.8
3.98
3.96
mmol/l
1.03
1572
14323
126
550
2.39
17.58
1.5
1.4
7.08
9.56
u/ml
—
5
14
1173
9852
1.60
17.53
5.7
4.3
—
—
—
0
0
1566
14252
2.07
17.27
18.2
13.5
21.09
23.67
mg/l
2.64
1288
11222
1635
15142
2.53
17.20
13.3
10.1
24.84
25.29
u/l
0.52
1589
14600
1601
14701
2.24
17.10
20.0
15.7
139.67
139.68
mmol/l
0.04
1569
14317
1136
9516
1.57
16.74
5.5
4.5
1736.42
2145.45
e6/l
0.09
19
143
1012
8294
1.53
16.20
4.9
4.6
6.48
6.65
mmol/l
2.14
973
7736
1177
9997
1.56
15.79
4.5
3.7
—
—
—
0
0
795
6257
1.50
14.96
12.1
9.1
0.00
0.00
e9/l
0.78
667
5085
573
4228
1.53
14.56
2.3
2.1
144.50
231.53
u/l
2.36
540
3965
1600
14826
2.09
14.44
16.9
12.9
—
—
—
0
0
767
6067
1.48
13.66
3.2
2.7
118.67
115.92
ug/l
0.15
707
5581
1672
15822
2.85
13.66
27.0
20.2
39.80
39.84
%
0.09
1520
14750
464
3311
1.55
13.57
4.7
3.6
—
—
—
0
0
326
2145
1.64
13.42
2.8
2.3
12.84
13.04
umol/l
0.18
301
1991
588
4425
1.50
13.35
2.8
2.4
58.64
60.58
u/l
0.35
539
4069
1672
15839
2.81
13.30
27.0
20.0
91.23
91.00
fl
1.17
1659
15603
1672
15840
2.81
13.28
27.0
20.0
30.38
30.26
pg
1.79
1659
15602
530
3907
1.51
13.28
4.0
3.0
0.30
0.46
e6/l
1.14
421
2952
199
1144
1.84
13.27
2.6
2.7
67.03
66.50
g/l
0.43
185
1038
1672
15841
2.81
13.26
27.1
20.1
6.60
6.67
e9/l
0.74
1641
15370
1672
15841
2.81
13.26
27.1
20.1
4.44
4.46
e12/l
1.01
1644
15375
180
1003
1.89
13.25
3.0
2.6
10.38
10.54
g/l
0.18
168
915
1672
15846
2.80
13.16
27.2
20.2
134.05
134.31
g/l
0.33
1660
15609
1671
15833
2.77
13.13
27.1
20.1
246.82
252.31
e9/l
2.96
1644
15414
650
5012
1.48
12.99
5.1
3.5
55.85
118.52
e6/l
2.08
485
3501
1265
11121
1.52
12.69
4.8
4.1
14.89
14.83
pmol/l
0.42
1164
10063
194
1122
1.82
12.68
3.9
3.5
95.51
82.37
ng/l
0.99
180
965
282
1829
1.65
12.20
2.9
2.3
22.48
22.61
%
0.05
226
1554
418
2979
1.53
12.09
3.5
2.4
4.20
6.28
e6/l
3.68
387
2671
298
1965
1.62
12.06
2.8
2.2
2.34
2.35
g/l
0.14
271
1813
238
1481
1.70
12.05
1.7
1.5
—
—
—
0
0
282
1836
1.64
12.01
1.5
1.3
—
—
—
0
0
437
3150
1.52
11.97
1.3
1.3
0.93
1.45
u/ml
1.26
125
809
476
3500
1.50
11.83
3.7
2.5
3453.73
6113.02
umol/l
0.86
420
3036
504
3758
1.48
11.66
5.5
4.0
0.00
0.00
estimate
1.08
169
1263
633
4934
1.45
11.63
3.6
3.4
2.35
2.36
mmol/l
1.23
570
4337
160
895
1.87
11.62
1.3
1.2
188.65
222.34
u/ml
0.24
150
814
562
4284
1.46
11.60
4.4
3.0
21.04
70.42
e6/l
2.50
450
3275
228
1427
1.69
11.27
1.8
1.5
—
—
—
0
0
385
2733
1.53
11.24
1.6
1.4
2.35
2.36
g/l
0.03
249
1624
507
3812
1.47
11.15
3.9
2.9
—
—
—
0
0
380
2695
1.53
11.13
4.2
3.7
203.63
372.00
ng/l
1.15
297
2113
728
5857
1.42
11.09
2.2
2.0
99.76
94.43
pmol/l
2.17
360
2943
1450
13251
1.59
11.08
5.9
4.9
1.92
2.05
mu/l
0.48
1361
12061
306
2074
1.58
10.97
2.1
2.1
30.19
29.74
s
0.63
295
2004
1536
14251
1.71
10.91
5.6
4.9
2.68
2.77
mmol/l
3.51
1429
13042
423
3080
1.49
10.90
5.2
4.0
1.02
1.02
kg/l
0.47
38
465
76
334
2.33
10.50
1.3
1.2
2.00
2.96
u/ml
—
9
35
347
2443
1.53
10.45
1.4
1.3
30.69
35.78
iu/ml
0.25
100
815
1427
13037
1.55
10.44
6.3
5.6
39.08
39.70
mmol/mol
2.17
1343
12001
396
2876
1.49
10.25
3.7
2.7
526.03
538.85
mosm/kgh2o
0.65
346
2462
141
791
1.85
10.14
2.3
1.8
1.85
1.47
g/l
0.35
131
723
76
340
2.29
10.09
1.3
1.2
8.80
9.44
u/ml
0.04
14
63
1490
13773
1.60
10.07
5.2
4.6
5.83
5.91
mmol/l
1.99
1375
12465
189
1159
1.71
10.05
10.2
6.6
10.34
9.30
mmol/l
1.30
184
1098
278
1884
1.57
9.91
2.1
1.9
—
—
—
0
0
159
936
1.77
9.76
2.3
2.4
—
—
—
0
0
474
3599
1.44
9.66
9.1
6.5
—
—
—
0
0
288
1983
1.54
9.54
1.3
1.2
—
—
—
0
0
415
3083
1.46
9.48
1.8
1.8
1.19
1.29
mg/l
0.19
314
2348
1319
11941
1.44
9.31
24.7
17.8
332.17
331.98
g/l
0.31
1312
11853
574
4536
1.40
9.25
4.0
3.2
31.01
32.16
u/l
0.43
547
4306
163
984
1.73
9.17
1.6
1.4
—
—
—
0
0
489
3787
1.41
8.79
4.7
3.9
—
—
—
0
0
1501
13988
1.56
8.77
5.1
4.4
4.60
4.69
mmol/l
3.32
1407
12887
494
3841
1.40
8.65
1.7
1.6
1.30
1.36
mmol/l
1.10
408
3216
440
3356
1.42
8.60
1.6
1.5
23.17
20.92
nmol/l
1.25
387
2823
578
4617
1.38
8.60
3.4
3.1
—
—
—
0
0
184
1168
1.64
8.57
4.8
3.2
—
—
—
0
0
59
256
2.35
8.45
1.2
1.2
24.95
35.42
u/ml
—
6
25
129
748
1.78
8.35
2.3
2.4
—
—
—
0
0
465
3599
1.40
8.31
2.5
2.2
2.82
2.99
mg/l
0.71
405
3034
555
4427
1.37
8.26
3.4
3.1
6.87
7.22
mmol/l
1.24
475
3720
185
1189
1.62
8.19
3.2
2.9
155.89
201.01
ng/l
1.48
171
1096
195
1271
1.60
8.15
2.5
2.1
359.52
374.75
nmol/l
0.43
182
1162
309
2230
1.47
8.08
4.1
3.3
0.81
0.82
mmol/l
0.38
287
2102
231
1574
1.54
7.96
2.9
2.7
6.31
7.75
umol/l
1.18
207
1365
244
1689
1.52
7.81
2.4
2.3
98.97
123.72
ug/g
1.09
192
1342
482
3787
1.38
7.79
4.1
3.4
—
—
—
0
0
1485
13880
1.50
7.77
4.9
4.3
1.50
1.50
mmol/l
0.27
1377
12691
51
217
2.39
7.65
1.2
1.3
—
—
—
0
0
31
102
3.08
7.60
1.2
1.1
95.00
163.68
titre
—
6
19
256
1808
1.49
7.43
1.7
1.6
—
—
—
0
0
223
1542
1.51
7.16
3.4
2.6
1.83
1.79
%
0.25
192
1357
542
4385
1.34
7.15
4.1
3.7
10.91
12.38
mg/mmol
0.11
315
2645
320
2380
1.42
7.06
3.4
2.6
1.03
1.27
e6/l
0.49
199
1332
195
1315
1.54
7.03
2.8
2.3
35.42
40.52
u/l
0.52
163
1119
514
4153
1.34
6.78
3.5
3.1
998.36
322.30
mg/l
1.20
295
2535
143
911
1.62
6.58
1.6
1.4
—
—
—
0
0
301
2245
1.41
6.50
3.6
2.8
2.91
2.88
e6/l
0.02
180
1204
506
4103
1.33
6.45
3.0
3.0
1475.34
1228.79
ng/l
0.25
428
3460
641
5374
1.31
6.43
3.7
3.5
43.53
49.21
ng/l
0.16
424
3701
172
1156
1.54
6.30
4.8
3.8
1.20
0.89
%
0.35
56
379
53
251
2.15
6.24
1.4
1.4
—
—
—
0
0
350
2695
1.37
6.24
2.8
3.0
2.46
2.46
mmol/l
0.00
309
2384
139
897
1.60
6.08
3.4
5.3
—
—
—
0
0
1427
13376
1.39
6.07
4.5
3.9
1.22
1.28
mmol/l
2.66
1307
12135
45
202
2.26
6.04
1.1
1.1
—
—
—
0
0
49
228
2.18
6.04
1.5
1.4
105.82
109.92
u/ml
—
10
41
61
309
2.01
6.03
1.7
1.6
—
—
—
0
0
46
209
2.23
6.01
1.2
1.3
—
—
—
0
0
169
1148
1.52
5.90
2.6
2.5
75.27
70.35
e9/l
0.82
117
866
290
2184
1.39
5.90
1.9
1.8
—
—
—
0
0
156
1043
1.54
5.86
4.9
3.9
0.12
0.07
%
0.28
41
268
67
357
1.91
5.75
1.3
1.2
60.91
79.31
titre
0.50
11
29
217
1559
1.45
5.74
5.4
7.7
1.51
1.12
mmol/l
1.04
166
1240
217
1561
1.45
5.70
5.4
7.6
5.05
5.09
kpa
0.24
204
1490
217
1562
1.45
5.68
5.4
7.6
11.92
12.21
kpa
0.39
202
1492
306
2344
1.37
5.60
1.4
1.3
11.41
14.19
u/ml
0.30
137
887
121
771
1.61
5.59
1.3
1.2
—
—
—
0
0
87
508
1.75
5.58
1.7
1.6
—
—
—
0
0
162
1108
1.51
5.48
1.1
1.2
—
—
—
0
0
96
580
1.69
5.45
1.9
1.9
1.49
1.54
g/l
0.16
84
499
155
1052
1.52
5.44
4.4
3.6
0.81
0.64
%
0.28
45
328
33
136
2.45
5.39
2.8
2.5
0.55
1.95
g/24h
1.85
11
70
84
497
1.73
5.16
2.1
2.0
21.22
21.34
s
0.10
69
453
1011
9129
1.26
5.15
3.3
3.0
44.91
47.08
u/l
0.40
961
8470
49
246
2.02
5.02
1.3
1.3
338.72
231.15
u/ml
1.20
32
141
158
1099
1.48
4.94
4.9
3.8
0.16
0.09
%
0.38
43
324
14
28
5.03
4.94
4.6
4.4
—
—
—
0
0
83
496
1.71
4.93
2.7
2.3
11.39
10.36
g/l
0.79
76
446
335
2658
1.32
4.81
1.8
1.7
1165.08
1190.53
nmol/l
0.20
265
1978
65
365
1.81
4.79
1.3
1.2
640.00
1094.00
titre
—
5
10
49
252
1.97
4.71
4.3
2.5
—
—
—
0
0
36
165
2.21
4.67
1.2
1.3
335.68
311.49
pmol/l
0.22
31
142
55
298
1.87
4.55
1.3
1.4
13.24
9.59
u/l
1.03
44
234
34
154
2.23
4.54
1.4
1.2
—
—
—
0
0
71
417
1.73
4.52
3.0
3.2
—
—
—
0
0
13
27
4.84
4.50
1.0
2.3
1.43
3.09
ug/l
—
6
12
68
396
1.75
4.46
1.9
2.1
3158.89
3798.37
u/l
0.09
21
171
39
189
2.09
4.42
1.3
1.3
0.63
0.67
nmol/l
0.27
39
180
73
436
1.70
4.38
3.9
7.2
1.27
1.31
mmol/l
0.14
68
382
59
332
1.80
4.35
1.7
1.8
6570.52
13623.70
e6/l
1.40
40
244
61
347
1.79
4.34
4.4
4.8
1.82
1.46
mg/l
1.93
54
315
31
138
2.27
4.32
1.4
1.2
—
—
—
0
0
126
861
1.50
4.32
1.3
1.3
44.64
46.05
au/ml
—
5
54
188
1395
1.39
4.16
5.4
8.1
96.39
95.46
%
2.27
183
1344
430
3587
1.26
4.15
4.9
3.7
88.75
90.41
%
0.69
415
3492
41
208
1.99
4.13
1.1
1.0
—
—
—
0
0
110
738
1.52
4.13
5.7
10.8
—
—
—
0
0
67
398
1.71
4.12
1.3
1.3
296.76
245.65
miu/ml
0.47
31
181
25
104
2.42
4.06
1.2
1.2
—
—
—
0
0
33
156
2.14
4.01
1.7
1.5
—
—
—
0
0
77
485
1.62
3.81
2.2
2.6
—
—
—
0
0
135
962
1.44
3.77
2.5
2.4
32.03
24.07
au/ml
—
7
70
137
980
1.43
3.75
1.2
1.2
132.74
144.07
iu/ml
0.12
51
377
178
1334
1.37
3.73
2.3
2.3
0.20
0.21
g/l
1.53
164
1260
745
6652
1.21
3.72
2.6
2.5
—
—
—
0
0
16
56
2.87
3.63
1.7
1.7
2.04
8.09
nmol/l
0.87
16
47
24
104
2.33
3.60
2.1
2.0
36.55
39.53
%
0.43
24
104
208
1606
1.34
3.59
1.4
1.3
—
—
—
0
0
13
35
3.73
3.59
1.4
1.2
—
—
—
0
0
69
431
1.63
3.55
2.3
2.2
38.14
37.71
g/l
0.25
63
383
412
3485
1.24
3.46
5.5
5.0
2.15
2.73
ug/l
1.06
371
3102
55
326
1.71
3.46
3.7
3.7
—
—
—
0
0
16
58
2.78
3.42
2.2
2.3
1016.06
1189.52
u/ml
0.21
16
58
13
37
3.53
3.40
2.5
1.9
—
—
—
0
0
34
174
1.97
3.40
1.3
1.3
—
—
—
0
0
158
1186
1.37
3.29
4.2
3.3
1.23
1.23
mmol/l
0.24
137
1015
38
205
1.87
3.27
3.5
2.6
—
—
—
0
0
42
236
1.80
3.19
1.2
1.2
—
—
—
0
0
165
1259
1.34
3.11
1.6
1.4
—
—
—
0
0
11
30
3.68
3.08
2.8
1.4
—
—
—
0
0
67
432
1.57
3.07
3.5
3.4
1.23
1.66
ratio
—
5
36
32
167
1.93
3.05
1.4
1.3
—
—
nmol/l
—
0
0
136
1799
0.74
3.00
5.1
4.5
33.30
32.88
%
0.17
106
1189
160
1230
1.33
2.88
4.9
4.0
—
—
—
0
0
57
360
1.60
2.87
1.1
1.2
—
—
—
0
0
67
441
1.54
2.83
3.6
3.5
29.84
83.65
mg/l
1.10
50
366
67
441
1.54
2.83
3.6
3.5
34.39
63.98
mg/l
1.35
50
366
49
299
1.66
2.82
4.4
4.2
3.08
2.66
mmol/l
0.28
26
199
39
225
1.75
2.75
2.0
1.8
1.78
1.69
mmol/l
0.15
39
220
11
34
3.25
2.72
1.0
1.0
—
—
—
0
0
64
421
1.54
2.72
1.6
1.5
269.44
285.73
ug/g
0.28
36
247
38
220
1.74
2.66
1.6
1.5
—
—
—
0
0
32
176
1.83
2.65
1.3
1.4
31.94
28.00
u/l
0.22
26
142
40
236
1.71
2.62
1.6
1.6
—
—
—
0
0
60
395
1.54
2.56
1.3
1.3
—
—
—
0
0
33
187
1.78
2.50
1.2
1.2
2.64
5.11
u/ml
0.98
11
79
121
914
1.35
2.48
1.2
1.2
—
—
—
0
0
361
3112
1.20
2.46
1.8
1.7
24161523.78
26351256.26
pmol/l
0.03
298
2554
45
280
1.62
2.44
5.5
3.7
—
—
—
0
0
159
1253
1.30
2.43
4.4
3.6
1.75
1.94
mmol/l
0.27
139
1026
90
651
1.40
2.41
2.5
1.9
—
—
—
0
0
168
1336
1.29
2.40
1.7
1.4
—
—
—
0
0
58
387
1.52
2.35
1.1
1.1
2.83
4.32
u/ml
—
7
43
20
98
2.05
2.32
1.4
1.4
1976.10
1828.77
ml
0.34
20
93
17
78
2.19
2.31
2.4
2.5
36.33
39.11
%
—
6
43
35
207
1.71
2.31
1.1
1.2
57.97
34.82
u/l
0.43
30
179
10
34
2.95
2.28
1.0
1.1
—
—
—
0
0
11
40
2.76
2.27
3.2
1.4
—
—
—
0
0
78
558
1.42
2.24
1.3
1.4
30.00
30.51
iu/l
0.04
69
475
103
774
1.35
2.21
2.3
2.1
12.16
12.47
nmol/l
0.15
91
676
137
1074
1.30
2.20
1.6
1.6
—
—
—
0
0
20
103
1.95
2.05
1.5
1.5
0.90
0.98
g/l
0.55
20
103
21
111
1.90
2.01
1.8
1.1
0.29
1.46
u/ml
0.80
14
59
142
1133
1.28
2.01
7.1
8.3
—
—
—
0
0
184
1514
1.24
2.00
1.5
1.6
—
—
—
0
0
20
105
1.92
1.96
2.1
1.6
2.66
3.76
mg/l
1.67
20
99
10
39
2.57
1.94
1.6
1.5
—
—
—
0
0
22
121
1.83
1.88
1.4
1.4
0.45
0.40
g/l
0.30
14
83
22
121
1.83
1.88
1.4
1.4
8.09
7.24
g/l
0.22
14
84
22
121
1.83
1.88
1.4
1.4
2.68
2.97
g/l
0.34
14
82
83
622
1.35
1.85
3.3
2.9
0.69
0.65
%
0.46
83
617
99
767
1.31
1.78
4.2
3.3
—
—
—
0
0
42
280
1.51
1.77
3.6
2.3
15.62
16.07
%
0.28
20
138
114
902
1.28
1.75
3.0
3.3
4.44
4.49
pmol/l
0.19
91
796
6
18
3.34
1.74
1.0
1.4
138.68
85.33
ng/l
—
6
18
29
178
1.64
1.73
2.2
1.9
—
—
—
0
0
22
125
1.77
1.72
1.5
1.4
—
—
—
0
0
58
417
1.40
1.69
1.2
1.1
—
—
—
0
0
16
83
1.94
1.64
3.0
1.9
369.60
503.51
e6/l
—
10
67
142
1165
1.24
1.62
2.0
2.3
7.38
7.12
ug/l
0.06
126
1022
40
271
1.49
1.59
3.6
2.1
—
—
—
0
0
58
422
1.39
1.59
1.5
1.5
277.52
305.86
mu/l
0.45
52
380
21
121
1.74
1.58
4.0
2.8
49.81
12.23
mg/l
0.65
16
86
6
20
3.01
1.58
1.7
1.7
—
—
—
0
0
32
207
1.56
1.57
1.5
1.7
0.48
0.83
g/l
2.02
23
159
25
153
1.64
1.53
3.8
2.8
—
—
—
0
0
20
115
1.75
1.52
1.5
1.2
—
—
—
0
0
34
225
1.52
1.52
1.5
1.5
—
—
—
0
0
39
266
1.48
1.52
1.5
1.4
58.06
62.05
mmol/l
0.26
32
217
7
27
2.60
1.51
1.1
1.4
—
—
—
0
0
40
276
1.46
1.47
2.3
3.5
—
—
—
0
0
10
45
2.23
1.46
1.8
1.9
—
—
—
0
0
10
45
2.23
1.46
1.3
1.6
—
—
—
0
0
28
179
1.57
1.46
2.7
2.5
—
—
—
0
0
144
1199
1.22
1.46
6.1
7.2
1.27
1.37
mmol/l
0.73
138
1167
11
52
2.12
1.44
1.0
1.1
1529.36
1647.79
miu/ml
0.16
11
52
82
640
1.30
1.44
3.3
2.9
1.14
1.14
%
0.01
82
635
14
73
1.93
1.44
1.1
1.2
—
—
—
0
0
52
379
1.38
1.43
4.7
4.3
—
—
—
0
0
6
22
2.73
1.43
1.0
1.1
—
—
—
0
0
31
204
1.53
1.43
1.8
1.2
—
—
—
0
0
17
96
1.78
1.39
1.1
1.1
—
—
—
0
0
29
190
1.54
1.37
2.0
1.9
—
—
—
0
0
9
41
2.20
1.37
1.1
1.5
88.11
81.54
nmol/24h
—
9
41
114
935
1.23
1.35
2.4
3.1
8.26
5.54
e9/l
0.47
95
755
14
75
1.87
1.34
1.5
1.5
—
—
—
0
0
14
75
1.87
1.34
1.1
1.0
—
—
—
0
0
21
129
1.64
1.30
2.0
1.3
—
—
—
0
0
5
18
2.78
1.28
1.0
1.1
6.41
5.34
mg/g
—
5
18
8
157
0.51
1.25
1.9
2.8
—
—
—
0
0
20
123
1.63
1.24
2.0
1.5
44.69
32.52
%
0.79
12
83
15
85
1.77
1.23
1.0
1.4
1.56
1.55
g/l
0.05
15
85
54
408
1.33
1.23
2.9
2.4
—
—
—
0
0
13
71
1.84
1.19
1.2
1.0
—
—
—
0
0
49
367
1.34
1.18
1.2
1.1
—
—
—
0
0
45
334
1.36
1.16
4.2
3.3
24.91
24.96
mmol/l
0.03
45
327
0
35
0.00
1.15
0.0
1.7
—
—
—
0
0
24
158
1.53
1.15
1.5
1.8
—
—
—
0
0
54
413
1.32
1.14
3.1
4.0
3.85
3.87
mmol/l
0.12
54
407
14
80
1.76
1.13
1.1
1.3
—
—
—
0
0
25
167
1.50
1.12
1.7
1.6
52.93
59.36
%
0.31
14
110
11
58
1.90
1.12
1.0
1.5
—
—
—
0
0
121
1426
0.84
1.11
4.9
3.9
—
—
—
0
0
114
957
1.20
1.11
3.2
3.0
—
—
—
0
0
15
88
1.71
1.11
1.9
1.6
—
—
—
0
0
451
4176
1.11
1.10
4.2
3.8
—
—
—
0
0
68
540
1.27
1.10
2.9
3.5
55.45
7437.17
u/ml
0.84
57
466
11
59
1.87
1.07
1.0
1.2
—
69.56
%
—
0
9
16
97
1.66
1.06
1.0
1.2
1.61
1.97
mmol/l
2.32
11
92
31
222
1.40
1.01
1.0
1.1
111.60
108.69
iu/ml
—
10
52
20
131
1.53
1.00
1.3
1.3
—
—
—
0
0
18
115
1.57
0.99
1.4
1.2
—
—
—
0
0
33
240
1.38
0.99
4.0
2.6
—
—
—
0
0
5
23
2.18
0.98
1.0
1.5
0.08
3.36
u/ml
—
5
23
0
30
0.00
0.97
0.0
1.2
—
—
—
0
0
35
258
1.36
0.97
1.2
1.3
—
—
—
0
0
66
532
1.25
0.97
4.5
4.7
—
—
—
0
0
20
132
1.52
0.97
1.3
1.4
12.51
3.08
ug/l
0.52
15
112
15
92
1.64
0.97
2.2
2.0
2.99
3.05
ug/l
0.02
15
84
7
36
1.95
0.97
1.0
1.1
—
—
—
0
0
61
488
1.26
0.96
1.1
1.1
—
—
—
0
0
22
149
1.48
0.95
2.5
1.9
—
—
—
0
0
7
37
1.90
0.94
1.0
1.1
—
—
—
0
0
102
864
1.19
0.94
6.9
9.1
0.70
0.68
%
0.20
102
856
14
221
0.63
0.93
1.4
1.5
—
—
—
0
0
44
339
1.31
0.92
1.1
1.3
473.03
524.95
mg/l
0.30
39
321
21
142
1.48
0.92
1.2
1.4
6.82
6.56
mmol/l
0.23
16
131
10
55
1.82
0.92
1.1
1.3
116.70
166.14
mmol/24h
—
10
55
20
134
1.50
0.91
1.4
1.4
—
—
—
0
0
8
42
1.91
0.88
1.0
1.1
—
—
—
0
0
38
289
1.32
0.88
2.8
3.2
0.75
0.84
nmol/l
0.90
31
229
15
95
1.58
0.87
1.0
1.2
0.11
8.23
nmol/l
—
5
16
14
217
0.64
0.87
1.2
1.4
—
—
—
0
0
21
144
1.46
0.87
1.5
1.4
60320.88
53764.36
e6/l
0.07
16
80
61
496
1.24
0.85
4.0
3.5
0.26
0.31
g/l
0.24
37
196
14
215
0.65
0.84
1.2
1.4
—
—
—
0
0
14
88
1.60
0.84
5.0
3.2
—
—
—
0
0
8
46
1.74
0.82
1.1
1.2
—
—
—
0
0
100
858
1.18
0.82
7.0
9.2
94.64
93.89
%
1.40
100
851
20
138
1.45
0.81
3.0
2.5
—
—
—
0
0
40
312
1.29
0.79
3.5
1.6
—
—
—
0
0
6
33
1.82
0.79
1.7
1.3
—
—
—
0
0
360
3858
0.92
0.79
1.4
1.4
—
—
—
0
0
8
48
1.67
0.78
3.6
2.1
—
—
—
0
0
8
48
1.67
0.78
1.3
1.2
—
—
—
0
0
40
313
1.28
0.78
2.9
3.4
16.15
25.58
mg/l
1.89
26
202
25
182
1.38
0.78
3.2
2.4
—
—
—
0
0
0
27
0.00
0.77
0.0
1.0
—
—
—
0
0
0
28
0.00
0.76
0.0
1.1
—
—
—
0
0
59
712
0.82
0.76
1.5
1.7
—
—
—
0
0
135
1195
1.14
0.75
1.6
1.4
—
—
—
0
0
30
391
0.76
0.74
1.3
1.3
—
—
—
0
0
102
886
1.16
0.73
3.9
4.1
5.14
5.13
kpa
0.01
96
841
15
100
1.50
0.73
1.9
2.3
—
—
—
0
0
9
57
1.58
0.71
2.4
2.4
65.67
45.74
umol/l
—
9
46
170
1536
1.12
0.69
3.7
4.2
8.72
21.14
ug/l
1.24
140
1261
19
135
1.41
0.69
1.5
1.3
—
—
—
0
0
5
27
1.85
0.68
3.0
2.5
8.94
19.12
umol/l
—
5
27
7
42
1.67
0.68
1.4
1.6
—
—
—
0
0
38
303
1.26
0.66
1.1
1.4
116.91
1278.61
e6/l
1.61
32
246
38
303
1.26
0.66
1.1
1.3
9.28
17.31
e6/l
0.54
29
239
100
877
1.15
0.65
3.9
4.1
7.39
7.41
ph
0.39
17
95
38
304
1.26
0.65
1.1
1.2
3.43
3.80
mmol/l
2.77
32
286
7
44
1.59
0.65
1.9
2.0
—
—
—
0
0
100
1136
0.87
0.65
1.4
1.3
—
—
—
0
0
10
62
1.62
0.65
2.8
2.5
43240.00
36765.21
ug/l
—
10
62
29
224
1.30
0.65
2.1
1.5
—
—
—
0
0
38
305
1.25
0.64
3.4
2.1
125.57
128.64
g/l
0.33
30
228
46
380
1.22
0.61
1.9
1.8
215.85
4.58
iu/l
0.47
15
131
26
200
1.30
0.60
1.1
1.1
—
—
—
0
0
22
165
1.34
0.60
1.5
1.4
1014.29
1715.68
e6/l
0.84
17
112
19
139
1.37
0.60
1.5
1.4
135115.31
136897.27
e6/l
0.00
13
96
0
20
0.00
0.60
0.0
3.4
—
—
—
0
0
0
20
0.00
0.60
0.0
6.8
—
—
—
0
0
26
201
1.30
0.59
1.1
1.1
—
—
—
0
0
13
90
1.45
0.55
1.0
1.1
—
10.91
—
0
21
17
125
1.36
0.53
1.2
1.2
—
—
—
0
0
38
316
1.21
0.49
2.7
2.3
47.73
81.52
ug/min
0.55
26
195
12
84
1.43
0.49
1.2
1.3
—
—
—
0
0
19
145
1.31
0.49
1.6
1.5
—
—
—
0
0
470
4508
1.06
0.48
2.6
2.3
—
—
—
0
0
24
190
1.27
0.48
1.2
1.2
—
—
—
0
0
95
853
1.12
0.47
3.3
3.5
25.18
54.12
u/ml
2.90
87
824
33
272
1.22
0.47
1.8
1.7
40.18
41.11
nmol/l
0.09
33
257
5
81
0.62
0.46
1.4
2.3
—
—
—
0
0
15
112
1.34
0.44
1.2
1.1
277.56
393.12
nmol/l
—
9
98
8
56
1.43
0.42
1.1
1.2
—
—
—
0
0
504
4865
1.05
0.41
3.3
2.8
—
—
—
0
0
28
231
1.22
0.41
1.2
1.1
0.48
2.44
u/ml
1.51
14
102
10
71
1.41
0.39
1.8
1.6
—
—
—
0
0
32
270
1.19
0.38
1.2
1.1
6.24
2.69
u/ml
0.38
22
151
19
151
1.26
0.38
1.3
1.3
—
—
—
0
0
9
66
1.37
0.38
1.4
1.3
197.21
163.78
pmol/l
—
9
66
9
66
1.37
0.38
1.4
1.6
—
—
—
0
0
14
107
1.31
0.37
1.7
1.4
—
—
—
0
0
5
37
1.35
0.37
1.0
1.1
19.82
19.46
mmol/l
—
5
31
6
42
1.43
0.35
6.0
1.6
15.56
13.51
g/l
—
6
29
47
414
1.14
0.35
3.1
1.5
—
—
—
0
0
44
386
1.14
0.34
3.2
1.6
—
—
—
0
0
6
46
1.31
0.33
2.5
2.2
—
—
—
0
0
6
46
1.31
0.33
1.7
1.3
—
—
—
0
0
22
184
1.20
0.30
1.2
1.5
0.37
0.30
nmol/l
0.17
15
141
47
419
1.13
0.30
3.7
1.5
—
—
—
0
0
31
270
1.15
0.28
1.1
1.3
—
—
—
0
0
10
76
1.32
0.28
1.1
1.2
0.39
3.20
u/ml
—
5
29
20
168
1.19
0.27
1.1
1.1
9.80
5.53
u/ml
—
7
65
8
66
1.21
0.26
2.5
2.8
1975.00
2006.75
ml
—
8
60
12
95
1.27
0.26
1.0
1.1
—
—
—
0
0
46
417
1.11
0.24
3.0
1.5
—
—
—
0
0
5
42
1.19
0.21
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
0.71
—
0
5
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
6
48
1.25
0.20
1.2
2.0
—
138.61
—
0
28
13
155
0.84
0.20
2.7
3.9
—
—
—
0
0
45
413
1.09
0.20
3.2
1.5
—
—
—
0
0
26
231
1.13
0.19
1.2
1.1
4.76
6.58
u/ml
0.33
14
120
15
175
0.86
0.19
1.1
1.2
—
—
—
0
0
7
62
1.13
0.17
1.4
2.7
—
—
—
0
0
25
224
1.12
0.17
1.2
1.2
—
—
—
0
0
7
63
1.11
0.17
1.6
1.2
—
—
—
0
0
15
129
1.16
0.17
1.1
1.1
—
—
—
0
0
8
68
1.18
0.16
2.6
2.9
—
—
—
0
0
8
70
1.14
0.16
1.9
1.3
145.13
134.69
nmol/l
—
8
70
20
177
1.13
0.16
2.4
1.6
—
—
—
0
0
11
93
1.18
0.14
1.5
1.4
89.27
81.41
umol/l
0.24
11
93
12
139
0.86
0.14
1.5
1.2
—
—
—
0
0
68
652
1.04
0.10
3.6
4.2
—
—
—
0
0
5
46
1.09
0.09
1.4
1.5
16.44
14.27
pmol/l
—
5
37
5
48
1.04
0.09
2.2
1.9
18.48
187.85
ug/l
—
5
41
12
107
1.12
0.08
2.6
2.9
11.58
10.96
%
0.17
12
107
79
765
1.03
0.08
1.5
1.4
—
—
—
0
0
13
144
0.90
0.08
1.3
1.4
—
—
—
0
0
20
185
1.08
0.08
1.3
1.0
1.17
2.26
u/ml
—
9
75
5
65
0.77
0.08
1.0
1.1
—
10.11
—
0
11
14
127
1.10
0.08
1.1
1.1
—
—
—
0
0
347
3433
1.01
0.07
2.4
2.2
—
—
—
0
0
12
130
0.92
0.04
1.3
1.2
—
—
—
0
0
16
150
1.07
0.04
1.1
1.1
—
—
—
0
0
23
220
1.05
0.03
1.2
1.0
0.67
1.77
u/ml
0.72
11
115
55
539
1.02
0.03
1.1
1.1
—
—
—
0
0
23
239
0.96
0.02
1.1
1.1
—
10.18
—
0
14
203
2018
1.01
0.02
3.1
3.0
0.82
0.78
ug/l
0.27
134
1331
16
153
1.05
0.01
1.1
1.0
0.09
0.51
u/ml
—
5
52
19
184
1.03
0.00
1.1
1.0
1.48
3.24
u/ml
—
10
87
14
145
0.97
0.00
1.6
2.5
10.11
8.37
umol/l
—
9
103
16
155
1.03
0.00
1.7
2.2
—
—
—
0
0
47
475
0.99
0.00
12.6
10.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
2.86
—
0
5
0
9
0.00
0.00
0.0
2.1
—
—
—
0
0
5
50
1.00
0.00
3.4
3.2
28.20
30.95
umol/l
—
5
37
0
5
0.00
0.00
0.0
1.6
—
43.40
—
0
5
0
9
0.00
0.00
0.0
1.3
—
6.21
—
0
9
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
157.83
—
0
6
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
92
0.98
-0.00
1.8
6.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_OTHPIGMENTATION and mortality.

Females

Parameter HR [95% CI] p-value
L12_OTHPIGMENTATION 0.759 [0.68, 0.85] < 0.001
Birth year 0.998 [0.99, 1.01] 0.564

During the follow-up period (1.1.1998 — 31.12.2019), 828 out of 6273 females with L12_OTHPIGMENTATION died.

Males

Parameter HR [95% CI] p-value
L12_OTHPIGMENTATION 0.914 [0.79, 1.06] 0.229
Birth year 0.988 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 538 out of 3664 males with L12_OTHPIGMENTATION died.

Mortality risk

Mortality risk for people of age

years, who have L12_OTHPIGMENTATION.

N-year risk Females Males
1 0.096% 0.162%
5 0.515% 1.012%
10 1.222% 2.626%
15 2.343% 5.337%
20 4.204% 9.004%

Relationships between endpoints

Index endpoint: L12_OTHPIGMENTATION – Other disorders of pigmentation

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data