obsolete_incontinentia pigmenti achromians: a dermal melanocytic condition affecting the shoulder area. Nevus of Ito often occurs in association with nevus of Ota in the same patient but is much less common, although the true incidence is unknown.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
215 |
4. Check minimum number of eventsNone |
215 |
5. Include endpointsNone |
215 |
6. Filter based on genotype QC (FinnGen only) |
182 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L81
- Name in latin
- Chloasma
Similar endpoints
↥List of similar endpoints to
Chloasma
based on the number of shared cases.
Similar with more cases:
- Other disorders of pigmentation
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 918 | 754 | 148 |
| Only index persons | 851 | 720 | 131 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.00 |
| Only index persons | 0.02 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 47.29 | 48.22 | 43.92 |
| Only index persons | 47.24 | 48.03 | 42.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 182 | 157 | 25 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.01 |
| Median age at first event (years) | 52.32 | 52.84 | 49.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 201
- Matched controls
- 2010
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L81.1
ICD-10 Finland
Chloasma
+∞
243.3
181
*
L57.0
ICD-10 Finland
Actinic keratosis
4.4
14.5
42
114
L82
ICD-10 Finland
Seborrhoeic keratosis
3.5
14.2
63
231
L81.4
ICD-10 Finland
Other melanin hyperpigmentation
63.5
10.7
12
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.0
9.2
28
78
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.4
8.0
73
380
7090A
ICD-9 Finland
Other disorders of skin and subcutaneous tissue, Dyschromia[CHLOASMA]
+∞
7.3
7
*
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
12.8
6.7
11
9
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
3.5
6.5
24
76
D10AX03
ATC
azelaic acid; topical
3.2
6.5
28
98
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
6.5
59
303
70901
ICD-8 Finland
Other diseases of skin, Chloasma symptomaticum aliud sive NUD
+∞
6.3
6
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
6.3
91
564
S08
ICPC
Skin colour change
3.8
6.0
19
54
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
33
137
2.69
5.66
1.6
1.5
—
—
—
0
0
88
572
1.96
5.06
2.4
2.3
57.24
62.56
u/l
0.29
79
524
106
757
1.85
4.39
4.6
3.8
37.06
36.34
g/l
0.92
101
717
20
76
2.81
4.04
2.1
1.5
—
—
—
0
0
15
48
3.30
4.02
1.1
1.5
0.00
0.01
iu/ml
—
5
6
18
68
2.81
3.67
2.2
1.7
—
—
—
0
0
78
529
1.78
3.67
1.9
1.9
114.36
143.64
u/l
0.98
72
507
17
64
2.81
3.49
1.3
1.3
280.90
313.29
ug/g
—
10
35
131
1045
1.73
3.33
9.7
9.7
3.81
3.94
e9/l
0.22
118
909
122
955
1.71
3.32
5.6
5.7
9.44
10.13
umol/l
0.65
112
900
123
975
1.67
3.10
4.2
3.7
55.81
0.00
estimate
0.49
27
205
122
968
1.66
3.04
4.2
3.6
0.00
0.01
estimate
0.50
25
198
124
988
1.67
3.04
4.3
3.7
0.00
0.00
estimate
-0.00
25
185
27
136
2.14
3.03
2.9
2.6
61.31
68.76
ml/min/173m2
0.54
13
54
5
5
10.21
2.99
1.0
1.0
2235.00
2439.60
miu/ml
—
5
5
22
104
2.25
2.87
1.0
1.1
—
—
—
0
0
51
331
1.72
2.69
4.6
3.2
34.95
298.39
ng/l
1.44
38
227
38
234
1.77
2.40
2.1
2.1
20.78
22.65
%
0.49
38
220
79
589
1.56
2.38
4.5
3.0
—
—
—
0
0
52
352
1.64
2.33
2.6
2.6
2.43
2.44
mmol/l
0.48
47
321
42
269
1.71
2.31
1.7
1.7
—
—
—
0
0
68
494
1.57
2.28
1.6
1.3
0.62
2.46
u/ml
1.13
17
128
22
116
2.01
2.21
1.8
1.4
—
—
—
0
0
14
61
2.39
2.20
1.3
1.2
—
—
—
0
0
6
14
4.38
2.16
2.2
2.4
4.32
3.96
nmol/l
—
6
14
60
431
1.56
2.09
1.9
1.5
—
—
—
0
0
5
10
5.10
2.08
1.8
1.5
95.40
83.27
ng/l
—
5
10
6
15
4.09
2.05
1.5
1.3
—
—
—
0
0
6
15
4.09
2.05
1.5
1.3
—
—
—
0
0
8
28
2.93
1.88
1.3
1.8
—
—
—
0
0
23
131
1.85
1.87
1.2
1.4
—
43.35
—
0
13
121
1023
1.46
1.84
3.7
4.2
6.27
6.39
mmol/l
0.29
114
941
30
187
1.71
1.82
3.8
6.9
104.77
104.58
mmol/l
0.10
30
187
90
721
1.45
1.81
3.8
3.4
0.00
0.02
estimate
0.50
17
159
6
18
3.40
1.76
1.2
1.1
—
—
—
0
0
106
882
1.43
1.71
2.9
2.5
80.54
78.48
nmol/l
0.31
101
797
106
883
1.42
1.69
7.1
6.2
1.24
1.22
mmol/l
2.40
93
759
8
31
2.64
1.68
1.9
1.3
—
—
—
0
0
8
31
2.64
1.68
1.9
1.3
—
—
—
0
0
7
25
2.86
1.66
1.0
1.6
—
—
—
0
0
30
193
1.65
1.63
1.9
1.7
—
—
—
0
0
37
254
1.56
1.55
3.3
3.1
2.49
3.67
e6/l
0.30
22
114
154
1388
1.47
1.50
5.2
4.2
10.39
11.11
mm/h
0.44
147
1292
38
265
1.54
1.49
1.6
1.6
1096.43
1134.11
nmol/l
0.10
32
195
31
206
1.60
1.49
1.9
1.6
—
—
—
0
0
23
142
1.70
1.46
2.1
1.6
—
—
—
0
0
53
398
1.45
1.46
1.4
1.3
22.15
32.72
iu/ml
0.34
13
138
39
275
1.52
1.46
3.1
2.9
1.12
0.92
e6/l
0.14
25
136
19
111
1.79
1.45
2.0
1.5
—
—
—
0
0
134
1185
1.39
1.39
3.4
3.4
—
—
—
0
0
5
17
2.99
1.36
1.2
1.1
—
—
—
0
0
95
798
1.36
1.35
5.7
5.4
1.24
1.22
mmol/l
2.26
85
725
55
422
1.42
1.34
3.1
3.4
1.02
1.02
kg/l
0.13
35
279
11
55
2.06
1.30
1.1
1.8
—
—
—
0
0
93
784
1.35
1.27
2.5
2.0
98.92
99.00
pmol/l
0.01
53
391
55
428
1.39
1.24
1.9
2.1
—
—
—
0
0
5
19
2.67
1.22
1.8
1.2
—
—
—
0
0
6
26
2.35
1.19
1.2
1.3
—
—
—
0
0
11
57
1.98
1.19
1.1
1.8
—
—
—
0
0
187
1779
1.73
1.17
17.3
13.3
17.97
19.94
mg/l
0.41
161
1427
11
58
1.95
1.14
1.4
1.4
—
—
—
0
0
97
837
1.31
1.08
2.3
2.5
—
—
estimate
—
0
0
24
163
1.54
1.08
2.4
3.8
203.46
250.57
u/l
2.53
24
156
159
1474
1.38
1.04
4.6
4.7
14.31
14.65
pmol/l
1.30
148
1369
10
53
1.93
1.03
1.5
2.1
22.81
24.92
mmol/l
—
10
53
9
48
1.92
1.02
1.6
1.1
—
—
—
0
0
5
23
2.20
0.98
1.2
1.2
—
—
—
0
0
60
491
1.32
0.97
2.6
2.7
604.13
818.83
ng/l
0.91
50
414
161
1503
1.36
0.94
21.6
17.6
331.47
331.30
g/l
0.08
161
1495
6
27
2.26
0.94
1.2
1.3
—
—
—
0
0
6
27
2.26
0.94
1.2
1.3
—
—
—
0
0
76
646
1.28
0.92
3.6
3.1
2.36
2.36
mmol/l
0.06
71
594
6
28
2.18
0.92
1.2
1.3
—
—
—
0
0
6
28
2.18
0.92
1.3
1.3
7.70
10.73
u/ml
—
6
28
6
28
2.18
0.92
1.2
1.2
—
—
—
0
0
6
28
2.18
0.92
1.2
1.3
—
—
—
0
0
179
1704
1.46
0.89
6.1
5.7
2.05
1.82
mu/l
2.00
171
1585
25
179
1.45
0.89
5.7
4.7
—
—
—
0
0
13
80
1.67
0.87
2.4
2.5
0.98
1.06
%
0.14
13
80
13
80
1.67
0.87
2.4
2.5
0.65
0.61
%
0.15
13
80
6
31
1.96
0.85
1.0
1.1
—
—
—
0
0
15
97
1.59
0.84
1.7
1.6
—
—
—
0
0
14
89
1.62
0.83
3.0
2.3
23.09
24.88
mmol/l
1.70
14
89
186
1788
1.54
0.83
6.2
5.7
2.92
2.80
mmol/l
1.20
177
1661
75
646
1.26
0.80
2.6
3.3
11.54
32.68
ng/l
2.28
43
423
51
420
1.29
0.78
2.4
2.5
309.96
321.00
umol/l
0.36
46
370
27
203
1.38
0.76
2.5
2.4
6.41
6.26
umol/l
0.02
22
174
5
24
2.11
0.75
1.4
1.4
—
—
—
0
0
62
529
1.25
0.71
4.1
3.6
0.00
0.01
estimate
0.50
24
182
179
1723
1.36
0.63
5.4
4.9
5.71
5.80
mmol/l
0.31
169
1593
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
178
1716
1.33
0.58
16.2
13.3
81.47
83.21
ml/min/173m2
0.60
172
1573
183
1771
1.37
0.58
5.7
5.0
4.87
4.79
mmol/l
0.58
175
1652
182
1760
1.36
0.58
5.6
4.9
1.51
1.56
mmol/l
0.95
171
1637
9
62
1.47
0.54
2.3
1.8
—
—
—
0
0
10
66
1.54
0.53
1.8
1.4
—
—
—
0
0
60
526
1.20
0.53
1.6
1.6
19.70
21.78
nmol/l
0.65
53
436
43
367
1.22
0.50
1.5
1.3
10.88
7.27
u/ml
0.15
22
140
10
142
0.69
0.48
3.3
3.7
1.24
1.23
mmol/l
—
10
119
18
139
1.32
0.45
4.8
4.3
19.37
21.92
%
—
7
57
5
31
1.63
0.43
1.2
1.1
—
—
—
0
0
23
188
1.25
0.39
3.4
4.2
2.98
8.63
ug/l
1.44
18
151
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
53
474
1.16
0.37
3.8
3.0
0.10
0.48
e6/l
2.16
42
343
21
172
1.25
0.36
7.2
5.4
1.94
1.67
ug/l
0.14
21
151
11
82
1.36
0.35
1.1
1.7
37.45
38.39
u/l
0.10
11
72
14
109
1.31
0.34
3.1
3.1
0.90
0.74
ug/l
—
8
62
28
240
1.19
0.32
2.9
1.9
—
—
—
0
0
171
1665
1.18
0.32
5.9
5.8
37.72
38.57
mmol/mol
0.93
165
1565
26
222
1.20
0.31
2.7
1.7
—
—
—
0
0
7
53
1.33
0.31
1.6
1.4
—
—
—
0
0
18
149
1.23
0.29
1.2
1.3
94.56
163.31
u/ml
—
9
66
85
800
1.11
0.27
2.1
1.9
1.26
1.33
mmol/l
0.48
72
676
47
430
1.12
0.24
1.9
1.6
0.66
1.06
mg/l
1.71
38
336
5
37
1.36
0.23
1.8
1.2
—
—
—
0
0
5
39
1.29
0.23
4.2
2.9
7.58
10.23
pmol/l
—
5
39
59
549
1.11
0.23
3.8
3.1
0.00
0.01
estimate
0.50
18
151
5
41
1.22
0.22
2.6
1.5
293.20
17370.90
e6/l
—
5
29
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
208.09
—
0
11
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
15.10
—
0
10
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
5
43
1.17
0.21
1.6
2.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
4.0
—
1.00
—
0
13
19
218
0.86
0.20
1.6
1.5
1.47
1.35
%
0.59
14
185
11
90
1.24
0.19
2.8
8.5
24.36
24.59
mmol/l
0.12
11
90
6
52
1.16
0.19
1.0
1.2
—
—
—
0
0
52
554
0.92
0.18
4.9
3.8
1.67
9.16
mg/mmol
3.54
24
307
8
68
1.18
0.17
1.0
1.1
1.59
1.63
g/l
—
8
68
8
70
1.15
0.16
1.0
1.1
0.93
0.89
g/l
—
8
70
9
79
1.15
0.15
1.8
1.4
—
—
—
0
0
14
160
0.87
0.14
2.9
3.3
—
—
—
0
0
170
1681
1.07
0.09
4.7
4.1
1.23
1.22
mmol/l
0.02
159
1549
6
54
1.11
0.09
1.2
1.5
32.00
6.39
ug/l
—
6
49
126
1245
1.03
0.05
4.0
3.1
36.67
40.27
u/l
0.48
121
1180
25
240
1.05
0.03
6.5
4.7
30.75
32.86
%
0.43
20
155
12
126
0.95
0.00
1.0
3.0
68.60
67.24
g/l
0.37
12
117
12
116
1.04
0.00
9.2
5.0
6.91
8.63
mmol/l
0.65
12
110
30
296
1.02
0.00
2.7
2.6
0.83
0.81
mmol/l
0.35
30
280
39
394
0.99
0.00
1.5
1.6
—
—
—
0
0
11
107
1.03
0.00
1.3
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
10.33
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
8.2
—
686.17
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
1.2
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
22.29
—
0
9
0
7
0.00
-0.00
0.0
3.9
—
4.75
—
0
7
6
60
1.00
-0.00
1.2
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.9
—
10.17
—
0
7
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.7
—
45.16
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
0.22
—
0
5
0
9
0.00
-0.00
0.0
5.3
—
207.56
—
0
9
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
34.01
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_CHLOASMA and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have L12_CHLOASMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: L12_CHLOASMA – Chloasma
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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