Other disorders of breast and lactation associated with childbirth

O15_BREAST_LACT_OTHER_DIS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

only females

313377

2. Check conditions

None

313377

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O92
  • Hospital discharge: ICD-9 676
  • Hospital discharge: ICD-8 6780[089]
  • Cause of death: ICD-10 O92
  • Cause of death: ICD-9 676
  • Cause of death: ICD-8 6780[089]

2 out of 7 registries used, show all original rules.

748

4. Check minimum number of events

None

748

5. Include endpoints

None

748

6. Filter based on genotype QC (FinnGen only)

689

Control definitions (FinnGen only)

Control exclude
O15_COMPLIC_PUERP

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
O85-O92
Name in latin
Alii morbositates mammmae et perturbationes lactationis ad partum adjunctae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3627 3627 -
Only index persons 3580 3580 -
Unadjusted period prevalence (%)
Whole population 0.10 0.10 -
Only index persons 0.13 0.13 -
Median age at first event (years)
Whole population - 31.25 -
Only index persons - 31.23 -

-FinnGen-

Key figures

All Female Male
Number of individuals 689 689 -
Unadjusted period prevalence (%) 0.24 0.24 -
Median age at first event (years) 31.68 31.68 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
716
Matched controls
7160
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O92.7
ICD-10 Finland
Other and unspecified disorders of lactation
2301.9
307.7
353
*
O92.4
ICD-10 Finland
Hypogalactia
+∞
99.3
93
*
O92.6
ICD-10 Finland
Galactorrhoea
43.3
92.8
56
14
O92.1
ICD-10 Finland
Cracked nipple associated with childbirth
490.7
89.2
87
*
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
4.5
87.0
360
1315
Z32.1
ICD-10 Finland
Pregnancy confirmed
4.3
83.0
376
1456
SPAT1379
SPAT
Health check-up of pregnant person
4.1
76.4
434
1940
Z37.0
ICD-10 Finland
Single live birth
4.1
75.0
323
1189
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
3.5
59.1
429
2139
SPAT1380
SPAT
Postpartum check-up
3.4
56.0
358
1637
SPAT1197
SPAT
Extensive health check-up of expecting family
3.4
55.2
431
2216
Z39.2
ICD-10 Finland
Routine postpartum follow-up
3.4
54.8
440
2297
WX307
NOMESCO Finland
Obstetric epidural analgesia
3.3
52.9
321
1412
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
3.3
52.8
451
2423
ZXE00
NOMESCO Finland
One hour or less
3.0
44.7
398
2122
ZXD10
NOMESCO Finland
Scheduled procedure
3.0
43.6
317
1510
O92.2
ICD-10 Finland
Other and unspecified disorders of breast associated with childbirth
+∞
43.2
41
*
O92.0
ICD-10 Finland
Retracted nipple associated with childbirth
217.1
40.3
41
*
Z34.0
ICD-10 Finland
Supervision of normal first pregnancy
2.8
39.7
360
1903
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
2.7
37.5
368
2009
R2110
NOMESCO Finland
Giving the first information
3.8
35.5
124
375
O92.5
ICD-10 Finland
Suppressed lactation
364.3
35.3
35
*
Z32
ICD-10 Finland
Pregnancy examination and test
6.7
33.4
55
88
W78
ICPC
Pregnancy
2.6
33.3
448
2795
O99.80
ICD-10 Finland
The fear of childbirth
3.0
30.8
169
672
O91.2
ICD-10 Finland
Nonpurulent mastitis associated with childbirth
6.3
25.4
44
74
N61
ICD-10 Finland
Inflammatory disorders of breast
3.7
24.2
84
251
67808
ICD-8 Finland
Mastitis and other disorders of lactation, Alia definitae
+∞
23.0
22
*
SPAT1317
SPAT
Planned health check-up monitoring, health check-up performed based on individual need
2.3
22.0
237
1279
TMA00
NOMESCO Finland
Episiotomy
3.1
21.4
99
353
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
2.3
21.0
211
1103
O36.9
ICD-10 Finland
Maternal care for fetal problem, unspecified
4.9
20.6
46
98
SPAT1315
SPAT
Periodic health check-up of children and adolescents
2.9
20.2
106
406
Z3232
NOMESCO Finland
Midwife
2.3
19.6
203
1070
O80.0
ICD-10 Finland
Spontaneous vertex delivery
2.1
19.6
420
2914
RF210, ,
NOMESCO Finland
4.5
18.6
47
111
WX321
NOMESCO Finland
Acute spinal anesthesia for delivery
2.6
18.4
121
519
S44
ICPC
Skin, Preventive immunization/medic
5.7
17.6
33
60
MA3AE
NOMESCO Finland
Combined first trimester screening
2.2
17.2
178
933
Z2221
NOMESCO Finland
Medical doctor
2.0
17.1
258
1557
W85
ICPC
Gestational diabetes
2.4
17.1
130
596
TQW30
NOMESCO Finland
Acupuncture
6.4
16.8
28
45
MA5AE
NOMESCO Finland
Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation
2.2
16.6
183
981
Z34
ICD-10 Finland
Supervision of normal pregnancy
2.4
16.2
135
644
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
3.5
16.1
58
177
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
2.4
15.8
121
556
MAX99
NOMESCO Finland
Assistance to normal delivery
2.0
15.7
233
1390
6764A
ICD-9 Finland
Other disorders of the breast associated with childbirth, and disorders of lactation, Failure of lactation
+∞
15.7
15
*
O86.1
ICD-10 Finland
Other infection of genital tract following delivery
27.0
15.7
21
8
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
2.1
14.8
186
1042
SPAT1246
SPAT
Screening of depression or other psychiatric problem
2.5
14.8
100
433
ZXD05
NOMESCO Finland
Urgent procedure
1.9
14.5
278
1799
O85
ICD-10 Finland
Puerperal sepsis
153.0
14.5
15
*
O86.8
ICD-10 Finland
Other specified puerperal infections
142.6
13.5
14
*
WX320
NOMESCO Finland
Spinalanesthesy
2.0
13.5
181
1035
O86.0
ICD-10 Finland
Infection of obstetric surgical wound
14.1
13.3
22
16
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.8
12.9
377
2749
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
12.3
306
2118
WX322
NOMESCO Finland
Combined spinal-epidural analgesia in obstetrics
2.8
12.2
64
243
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
1.9
11.9
186
1114
Z3226
NOMESCO Finland
Physiotherapist
2.1
11.6
122
635
O71.4
ICD-10 Finland
Obstetric high vaginal laceration
4.9
11.5
25
52
67809
ICD-8 Finland
Mastitis and other disorders of lactation, Unspecified
+∞
11.5
11
*
MAC01
NOMESCO Finland
Rupture of aminiotic membrane for induction of labor
2.8
11.4
57
211
Z39.1
ICD-10 Finland
Care and examination of lactating mother
2.7
11.3
63
247
N64.3
ICD-10 Finland
Galactorrhoea not associated with childbirth
5.5
10.9
21
39
SPAT1399
SPAT
Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.
2.1
10.9
121
643
WW200, ,
SPAT
1.8
10.6
194
1216
Z30.1
ICD-10 Finland
Insertion of (intrauterine) contraceptive device
1.7
10.5
261
1786
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
1.8
10.4
229
1514
O70.0
ICD-10 Finland
First degree perineal laceration during delivery
3.9
10.3
30
79
O80.8
ICD-10 Finland
Other single spontaneous delivery
2.1
10.3
112
590
SPAT1196
SPAT
Monitoring of normal pregnancy
1.9
9.9
160
962
W90
ICPC
Uncompl labour/delivery livebirth
1.9
9.9
135
770
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
1.7
9.8
419
3286
Z39
ICD-10 Finland
Postpartum care and examination
3.4
9.8
36
111
O26.88
ICD-10 Finland
Other specified pregnancy-related conditions
3.2
9.8
39
127
SPAT1195
SPAT
Antenatal classes
2.2
9.8
84
403
O64.0
ICD-10 Finland
Obstructed labour due to incomplete rotation of fetal head
2.8
9.7
49
183
P01AB01
ATC
metronidazole; oral, rectal
1.7
9.6
315
2307
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
9.3
204
1341
O26.82
ICD-10 Finland
Exhaustion and fatigue pregnancy-related
2.4
8.9
62
271
MBC30
NOMESCO Finland
Repair of partial rupture of perineum
2.7
8.8
49
193
O64.1
ICD-10 Finland
Obstructed labour due to breech presentation
3.2
8.6
34
110
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.9
8.4
112
631
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
1.9
8.4
111
625
6768X
ICD-9 Finland
Other disorders of the breast associated with childbirth, and disorders of lactation, Other disorders of lactation
+∞
8.3
8
*
O26.7
ICD-10 Finland
Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium
3.5
8.1
28
83
G02CB01
ATC
bromocriptine; systemic
3.8
8.1
24
64
MWA00
NOMESCO Finland
Repair of wound dehiscence in obstetric surgery
33.8
8.1
10
*
Z36.0
ICD-10 Finland
Antenatal screening for chromosomal anomalies
1.8
8.0
133
804
MBA30
NOMESCO Finland
Manual removal of placenta from delivered uterus
3.0
8.0
35
121
W05
ICPC
Pregnancy vomiting/nausea
3.1
7.7
32
107
W94
ICPC
Puerperal mastitis
3.5
7.6
26
77
O86.4
ICD-10 Finland
Pyrexia of unknown origin following delivery
80.9
7.4
8
*
O32.1
ICD-10 Finland
Maternal care for breech presentation
2.0
7.4
78
405
LC2HE
NOMESCO Finland
Hystero-salpingography with ultrasound
2.0
7.4
83
441
O92.3
ICD-10 Finland
Agalactia
+∞
7.3
7
*
SEMI, ,
NOMESCO Finland
7.4
7.2
16
22
SAA02
NOMESCO Finland
Basic examination of mouth
1.7
7.1
580
5120
O70.1
ICD-10 Finland
Second degree perineal laceration during delivery
2.2
7.1
62
300
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
6.9
527
4553
O20.0
ICD-10 Finland
Threatened abortion
2.6
6.6
39
158
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
6.5
269
2032
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
6.4
131
836
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
2.7
6.4
33
125
O75.7
ICD-10 Finland
Vaginal delivery following previous caesarean section
6.6
6.4
15
23
O73.0
ICD-10 Finland
Retained placenta without haemorrhage
3.6
6.4
20
56
O20.9
ICD-10 Finland
Haemorrhage in early pregnancy, unspecified
2.1
6.3
62
314
6765A
ICD-9 Finland
Other disorders of the breast associated with childbirth, and disorders of lactation, Suppressed lactation
+∞
6.3
6
*
O47
ICD-10 Finland
False labour
3.0
6.2
27
93
J01DB01
ATC
cefalexin; oral
1.7
6.2
598
5379
SPAT1281
SPAT
Other administrative function
2.0
6.1
69
367
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
6.0
320
2533
W84
ICPC
Pregnancy high risk
1.8
6.0
88
510

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
286
832
5.06
94.01
1.7
1.5
—
—
—
0
0
283
822
5.04
93.07
1.7
1.5
1.16
1.26
mm
2.95
141
605
285
854
4.88
89.71
1.8
1.6
—
—
—
0
0
316
1074
4.48
83.50
1.8
1.5
58.72
60.29
ug/l
0.20
223
913
303
998
4.53
83.50
1.7
1.5
1.11
1.13
ratio
0.15
196
611
300
992
4.48
82.01
1.7
1.5
—
—
—
0
0
118
272
5.00
48.98
2.5
2.4
1.02
1.02
ratio
0.93
112
240
305
1350
3.19
48.97
2.7
2.2
—
—
—
0
0
315
1479
3.02
44.73
3.9
2.7
0.06
0.28
e6/l
5.62
216
1026
308
1450
2.97
43.21
3.8
2.7
—
0.98
estimate
—
0
6
335
1711
2.80
39.48
3.9
2.9
13.62
62.10
e6/l
1.78
235
1242
255
1145
2.91
38.16
2.9
2.5
6.87
10.86
e6/l
2.62
198
1027
206
850
3.00
35.65
3.1
2.4
0.46
1.51
e6/l
0.94
135
404
347
1900
2.60
34.29
1.8
1.6
1107.11
1012.91
mu/l
0.77
204
1614
193
796
2.95
33.16
3.0
2.5
3.10
4.41
e6/l
1.17
123
347
159
604
3.10
31.47
2.9
2.2
6.35
6.29
ph
0.43
131
387
372
2283
2.31
26.42
4.2
3.4
29.30
46.43
e6/l
1.07
250
1378
208
1001
2.52
25.58
2.9
2.5
537.66
529.26
mosm/kgh2o
0.21
174
880
481
3467
2.18
20.81
3.2
2.7
—
—
estimate
—
0
0
426
2941
2.11
20.51
2.1
1.9
—
—
—
0
0
28
37
7.83
20.07
2.3
3.4
—
—
—
0
0
137
605
2.56
19.71
2.4
1.8
0.00
0.02
estimate
—
9
160
399
2747
2.02
18.66
2.0
1.8
—
—
—
0
0
28
41
7.07
18.36
2.3
3.2
—
—
—
0
0
218
1235
2.10
17.21
1.3
1.4
—
—
—
0
0
415
3023
1.89
15.11
2.5
2.0
—
—
—
0
0
258
1649
1.88
13.86
1.8
1.8
—
—
—
0
0
438
3417
1.73
11.06
2.3
2.3
—
—
—
0
0
105
529
2.15
10.84
1.2
1.3
—
—
—
0
0
311
2256
1.67
9.95
1.9
1.9
—
—
—
0
0
184
1206
1.71
8.37
2.2
2.5
55.37
88.83
ug/g
3.71
154
920
77
382
2.14
8.22
2.0
2.1
3.96
4.66
umol/l
0.72
59
281
197
1334
1.66
7.86
2.2
3.2
97.53
97.54
%
0.00
190
1298
436
3667
1.48
6.03
3.1
3.4
0.00
0.00
estimate
0.50
81
836
437
3707
1.46
5.57
3.2
3.4
0.00
7.78
estimate
1.33
81
827
509
4449
1.50
5.56
3.9
3.5
49.40
52.82
ug/l
0.97
497
4255
436
3717
1.44
5.27
3.5
3.5
0.10
0.00
estimate
0.80
80
813
123
815
1.61
5.18
1.9
1.9
—
—
—
0
0
33
144
2.35
4.84
1.4
1.4
—
—
—
0
0
234
1810
1.43
4.70
1.4
1.4
1.92
2.05
g/l
1.29
137
1186
114
762
1.59
4.62
1.5
1.6
266.87
290.35
mu/l
0.33
108
680
475
4167
1.42
4.54
5.3
6.4
66.31
69.67
u/l
2.33
436
3948
35
162
2.22
4.51
3.2
2.8
—
24.76
—
0
6
270
2172
1.39
4.25
1.4
1.3
1.54
1.46
u/ml
0.05
68
623
672
6374
1.88
4.11
10.9
10.5
18.70
18.29
mg/l
0.14
559
5116
410
3543
1.37
4.07
5.6
8.3
4.04
4.00
e9/l
0.12
341
3106
658
6221
1.71
3.82
6.2
5.8
1.50
1.68
mu/l
6.31
644
6005
370
3238
1.30
2.96
4.3
5.9
0.04
0.04
e9/l
0.77
303
2870
21
95
2.25
2.92
4.0
3.4
—
—
—
0
0
677
6510
1.73
2.88
8.4
8.7
22.06
22.47
u/l
0.34
669
6349
566
5264
1.36
2.82
4.0
4.2
35.19
36.16
mmol/mol
2.77
546
5062
8
18
4.48
2.80
1.1
1.0
—
—
—
0
0
8
18
4.48
2.80
1.1
1.0
—
—
—
0
0
8
18
4.48
2.80
1.1
1.0
—
—
—
0
0
9
23
3.95
2.78
1.0
1.1
—
—
—
0
0
368
3236
1.28
2.77
4.3
5.8
0.50
0.52
e9/l
0.93
305
2872
624
5906
1.44
2.73
8.7
9.4
139.55
139.38
mmol/l
1.41
616
5758
692
6708
1.94
2.70
9.9
9.9
—
—
—
0
0
379
3352
1.28
2.69
4.3
6.1
0.18
0.17
e9/l
0.33
345
3020
9
24
3.78
2.68
1.2
1.0
189.33
329.05
u/l
—
9
19
100
730
1.43
2.67
1.3
1.2
—
—
—
0
0
199
1623
1.31
2.65
1.6
1.6
—
—
—
0
0
112
837
1.40
2.62
1.2
1.3
14.58
16.40
iu/l
0.40
101
716
378
3352
1.27
2.59
4.3
5.8
1.99
1.99
e9/l
0.00
347
3046
14
313
0.44
2.56
2.0
1.8
0.00
0.03
estimate
—
9
122
333
2914
1.27
2.53
2.5
2.5
76.36
72.57
nmol/l
1.65
304
2766
623
5911
1.42
2.53
8.8
9.4
3.85
3.87
mmol/l
1.43
616
5749
337
2961
1.26
2.45
4.3
5.7
2.70
2.62
%
0.26
306
2792
33
190
1.77
2.41
1.1
1.3
—
—
—
0
0
29
161
1.84
2.38
4.6
7.6
—
—
—
0
0
594
5605
1.35
2.38
5.2
4.9
13.95
14.21
pmol/l
2.49
574
5327
36
214
1.72
2.37
1.2
1.1
—
—
—
0
0
36
214
1.72
2.37
1.2
1.1
—
—
—
0
0
336
2960
1.25
2.36
4.3
5.7
0.61
0.66
%
1.04
301
2783
78
559
1.44
2.31
2.8
2.1
31.35
33.36
u/l
0.27
66
458
6
14
4.31
2.15
1.2
1.1
—
—
—
0
0
111
860
1.34
2.09
2.0
2.0
2.36
2.40
mmol/l
3.44
89
756
83
615
1.40
2.06
1.8
2.2
4.64
5.08
umol/l
0.39
69
504
130
1034
1.31
2.05
2.6
3.3
—
—
—
0
0
164
1347
1.28
2.03
1.4
1.3
4.03
9.28
u/ml
1.55
66
564
502
4677
1.25
1.95
2.6
2.8
23.47
27.48
u/l
3.12
488
4503
346
3103
1.22
1.94
4.3
5.6
29.70
29.79
%
0.06
316
2968
84
633
1.37
1.90
1.2
1.4
—
—
—
0
0
669
6485
1.48
1.86
10.5
11.1
63.59
64.73
umol/l
2.08
664
6404
69
506
1.40
1.84
1.2
1.2
—
—
—
0
0
577
5477
1.28
1.82
3.0
3.1
1.10
1.11
mmol/l
0.22
558
5243
94
727
1.34
1.81
1.5
1.8
—
—
—
0
0
149
1227
1.27
1.80
2.0
2.2
281.89
290.19
umol/l
0.69
135
1122
176
1479
1.25
1.80
1.4
1.3
14.67
22.96
iu/ml
1.70
35
415
330
2962
1.21
1.79
4.4
5.8
7.71
8.03
%
1.81
297
2803
36
233
1.57
1.77
1.0
1.1
—
—
—
0
0
18
95
1.92
1.76
1.6
1.3
—
1235.29
—
0
17
202
1730
1.23
1.73
3.4
5.4
—
—
—
0
0
589
5624
1.27
1.64
3.5
3.5
5.37
5.48
mmol/l
2.47
573
5332
18
98
1.86
1.63
1.2
1.6
—
—
—
0
0
358
3259
1.20
1.62
4.0
3.9
5.97
6.05
mmol/l
0.46
279
2844
303
2719
1.20
1.60
4.1
4.7
9.62
9.29
umol/l
0.51
286
2556
43
297
1.48
1.60
5.0
5.9
1.05
1.20
mmol/l
0.96
43
291
25
152
1.67
1.58
1.4
1.3
313.80
337.90
ug/g
—
10
73
103
826
1.29
1.55
1.8
2.2
2.53
2.50
g/l
0.25
96
756
188
1616
1.22
1.55
2.7
3.4
1.02
1.95
kg/l
0.50
123
1080
8
33
2.44
1.54
1.0
1.0
—
—
—
0
0
135
1122
1.25
1.52
1.5
1.4
460.69
538.76
titre
0.28
29
241
75
578
1.33
1.50
1.3
1.3
310.98
239.81
miu/ml
0.83
41
297
15
266
0.55
1.47
3.7
7.7
5.35
6.59
mmol/l
1.02
15
261
9
38
2.39
1.46
4.0
3.0
455.78
569.24
u/ml
—
9
38
12
59
2.05
1.44
1.6
1.8
5.28
5.41
mmol/l
0.16
12
49
19
111
1.73
1.40
1.6
1.3
—
—
—
0
0
94
757
1.28
1.38
2.4
2.6
218.82
190.56
ng/l
0.06
27
338
81
640
1.30
1.38
1.5
1.6
—
—
—
0
0
83
661
1.29
1.33
1.5
1.3
—
—
—
0
0
334
3060
1.17
1.32
4.3
5.6
56.98
56.74
%
0.17
310
2942
199
1751
1.19
1.27
2.4
2.7
2.34
2.34
mmol/l
0.18
192
1623
8
36
2.24
1.24
4.4
1.8
—
—
—
0
0
24
155
1.57
1.24
1.1
1.4
2.29
4.17
u/ml
—
7
66
35
246
1.44
1.23
1.0
1.1
1.39
0.99
u/ml
0.25
19
101
57
437
1.33
1.21
1.2
1.2
9.49
10.24
u/l
0.21
51
356
191
1683
1.18
1.20
2.3
2.4
54.59
58.33
u/l
0.60
175
1570
26
173
1.52
1.19
1.0
1.1
8.10
18.30
au/ml
—
9
53
39
282
1.41
1.19
1.6
1.4
—
—
—
0
0
251
2263
1.17
1.19
1.9
1.8
100.43
97.94
pmol/l
0.35
140
1314
89
727
1.26
1.18
1.3
1.3
—
—
—
0
0
87
710
1.26
1.17
1.7
2.0
406.41
379.91
nmol/l
0.81
82
662
10
50
2.01
1.17
1.0
1.5
—
—
—
0
0
8
39
2.06
1.15
1.3
1.1
—
—
—
0
0
5
20
2.51
1.15
1.4
1.3
123.80
161.33
mmol/24h
—
5
20
42
310
1.38
1.15
3.3
3.7
57.70
66.84
ng/l
1.14
37
281
176
1990
0.85
1.14
2.9
3.4
0.00
0.00
estimate
1.08
80
808
7
30
2.35
1.12
1.1
1.2
0.02
0.03
u/ml
—
7
30
8
40
2.01
1.12
1.5
1.3
—
—
—
0
0
35
252
1.41
1.10
1.1
1.1
1.03
1.38
u/ml
0.21
21
124
27
385
0.69
1.10
1.1
1.3
—
—
—
0
0
8
41
1.96
1.09
1.3
1.7
1.71
1.81
umol/l
—
8
34
111
939
1.22
1.08
1.6
1.5
—
—
—
0
0
36
262
1.39
1.08
1.0
1.1
7.84
5.29
u/ml
0.31
24
143
42
314
1.36
1.07
1.5
1.9
—
—
—
0
0
37
271
1.39
1.07
2.5
2.4
2.51
3.47
iu/l
0.68
13
120
45
342
1.34
1.04
1.7
1.9
20.68
4.73
iu/ml
0.59
12
78
214
1926
1.16
1.02
4.4
5.6
—
—
—
0
0
163
1437
1.17
1.01
1.7
1.5
22.14
21.00
nmol/l
0.48
146
1283
319
2956
1.14
1.01
2.6
3.1
6.34
6.29
ph
0.37
187
1705
612
5942
1.21
1.00
3.6
3.6
4.65
4.70
mmol/l
0.76
599
5727
39
292
1.35
1.00
2.1
1.6
—
—
—
0
0
0
31
0.00
0.96
0.0
1.1
—
—
—
0
0
58
463
1.27
0.96
1.2
1.2
—
—
—
0
0
610
5926
1.20
0.96
3.5
3.5
1.50
1.53
mmol/l
1.23
597
5698
39
295
1.34
0.94
1.1
1.1
3.62
2.90
u/ml
0.12
28
151
45
348
1.31
0.94
1.1
1.1
—
—
—
0
0
101
1178
0.83
0.93
2.3
2.3
8134.14
7079.44
u/l
0.12
45
525
199
1796
1.15
0.91
3.1
3.9
—
—
—
0
0
147
1304
1.16
0.85
1.9
1.9
99.10
168.35
u/l
0.81
142
1254
54
664
0.80
0.85
1.6
1.5
1170.32
1142.10
nmol/l
0.10
45
514
285
2651
1.12
0.81
1.9
1.9
—
—
—
0
0
9
149
0.60
0.79
1.7
2.0
13.22
13.03
%
—
9
149
303
2832
1.12
0.79
2.7
3.2
0.01
0.02
estimate
0.12
73
706
0
25
0.00
0.79
0.0
1.3
—
17.70
—
0
17
0
26
0.00
0.78
0.0
2.3
—
14.38
—
0
26
0
26
0.00
0.78
0.0
1.3
—
—
—
0
0
13
82
1.60
0.78
1.1
1.0
—
—
—
0
0
17
115
1.49
0.77
1.6
2.5
4.64
1.58
index
0.28
11
59
11
67
1.65
0.75
1.0
1.0
—
—
—
0
0
206
2233
0.89
0.71
2.5
2.7
0.01
0.09
estimate
0.50
68
704
9
59
1.53
0.68
1.0
1.1
—
—
—
0
0
611
5976
1.15
0.67
3.8
3.8
2.78
2.78
mmol/l
0.05
597
5749
5
28
1.79
0.66
1.4
1.9
—
—
—
0
0
10
62
1.62
0.65
1.3
1.3
—
—
—
0
0
59
498
1.20
0.64
2.4
2.3
16.91
18.18
au/ml
0.08
11
66
5
29
1.73
0.64
2.4
1.7
—
2093.33
—
0
6
26
199
1.32
0.63
1.0
1.0
0.03
0.11
u/ml
1.07
12
56
11
71
1.56
0.62
1.3
1.4
14.35
24.03
ng/l
1.83
11
71
40
327
1.24
0.60
1.6
1.6
26.49
8.47
u/ml
0.80
13
91
27
210
1.30
0.59
1.7
1.4
26.98
38.23
nmol/l
1.94
27
194
168
1543
1.12
0.59
1.6
1.8
1.11
0.86
mg/l
0.24
129
1149
0
22
0.00
0.59
0.0
2.2
—
9.48
—
0
17
10
64
1.57
0.59
1.3
1.3
1.82
2.97
g/l
—
5
49
10
64
1.57
0.59
1.3
1.3
6.54
6.01
g/l
—
5
49
10
64
1.57
0.59
1.3
1.3
0.25
0.38
g/l
—
5
49
5
86
0.58
0.56
1.0
2.6
—
—
—
0
0
34
275
1.25
0.56
6.6
7.2
—
—
—
0
0
70
609
1.17
0.56
1.3
1.3
—
—
—
0
0
43
512
0.83
0.54
1.5
2.1
25.88
37.80
u/ml
0.84
43
491
6
38
1.58
0.54
1.8
1.9
70.00
56.00
%
—
6
33
99
1101
0.88
0.53
3.9
4.4
15.94
11.53
mg/mmol
0.29
50
715
208
1944
1.10
0.53
2.3
2.3
—
—
—
0
0
13
93
1.41
0.48
2.8
1.6
6.36
5.07
mmol/24h
0.60
13
83
34
284
1.21
0.44
1.2
2.1
21.08
19.95
s
0.88
26
243
17
130
1.32
0.44
3.4
4.6
36.96
36.97
°c
0.04
17
130
28
230
1.23
0.43
1.1
1.1
1.39
4.36
u/ml
1.81
16
112
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
4.1
—
0.63
—
0
16
0
17
0.00
0.40
0.0
2.3
—
—
—
0
0
17
132
1.29
0.40
1.2
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
4.3
—
0.78
—
0
18
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
82.82
—
0
11
14
106
1.33
0.39
1.2
1.4
0.52
0.46
g/l
—
8
87
143
1528
0.92
0.38
3.0
3.5
7.14
7.76
mmol/l
0.78
121
1351
9
69
1.31
0.37
1.3
1.1
—
—
—
0
0
14
180
0.77
0.37
4.3
5.7
24.16
24.01
mmol/l
0.07
14
172
10
72
1.39
0.37
1.0
1.2
—
—
nmol/l
—
0
0
22
267
0.82
0.36
1.0
1.1
2.00
6.20
eliau/ml
—
5
37
120
1116
1.09
0.35
1.7
1.6
3.18
3.17
ratio
0.03
86
788
6
42
1.43
0.35
1.3
2.2
11.20
11.29
%
—
6
42
6
42
1.43
0.35
2.3
2.2
—
—
—
0
0
6
44
1.37
0.34
1.0
1.0
—
10.25
—
0
6
6
44
1.37
0.34
1.2
1.3
93.40
92.50
%
—
6
44
101
1090
0.91
0.34
3.5
3.8
93.91
61.25
mg/l
0.33
59
736
6
45
1.34
0.34
1.8
1.3
—
94.20
—
0
5
79
723
1.10
0.33
1.4
1.5
—
—
—
0
0
18
146
1.24
0.32
1.1
1.1
—
—
—
0
0
66
600
1.11
0.31
3.4
3.5
4.72
4.64
pmol/l
0.22
58
543
7
52
1.35
0.31
1.7
2.3
1.14
0.93
%
—
7
47
11
142
0.77
0.31
1.1
1.2
—
—
—
0
0
16
196
0.81
0.30
2.1
2.6
44.73
105.27
ng/l
2.10
11
168
25
213
1.18
0.29
1.0
1.1
2.03
5.84
u/ml
1.50
11
94
17
139
1.23
0.29
2.2
2.8
58.68
59.24
%
0.08
17
139
8
106
0.75
0.29
7.4
3.3
0.69
1.02
nmol/l
—
8
92
12
94
1.28
0.28
1.5
2.0
12.00
5.83
pmol/l
0.43
12
94
24
279
0.86
0.27
8.0
7.2
118.96
120.43
g/l
0.14
24
274
78
724
1.09
0.26
2.2
2.8
0.89
0.83
mmol/l
1.39
73
695
297
2884
1.05
0.25
6.5
8.7
0.00
0.00
e9/l
0.99
215
2369
9
73
1.24
0.25
1.1
1.3
—
—
—
0
0
9
75
1.20
0.25
1.4
2.0
56.00
61.57
%
—
9
75
10
126
0.79
0.24
1.7
2.5
—
—
—
0
0
94
884
1.07
0.23
1.5
1.5
3.23
3.29
mmol/l
0.20
62
572
7
92
0.76
0.22
1.4
1.6
0.41
0.50
e9/l
—
7
92
5
40
1.25
0.22
1.2
1.1
191.60
159.66
iu/ml
—
5
40
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
19.86
—
0
10
0
12
0.00
0.21
0.0
1.1
—
20326.17
—
0
6
0
12
0.00
0.21
0.0
1.1
—
40.83
—
0
6
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
295
2878
1.04
0.20
2.2
2.2
—
—
—
0
0
6
48
1.25
0.20
1.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
3175.89
—
0
9
0
14
0.00
0.20
0.0
1.7
—
59.79
—
0
14
0
14
0.00
0.20
0.0
3.0
—
16.27
—
0
14
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
17
197
0.86
0.20
1.4
1.6
—
8.84
—
0
7
95
998
0.94
0.18
1.2
1.3
—
—
—
0
0
138
1434
0.95
0.18
1.7
1.6
—
—
—
0
0
7
61
1.15
0.17
1.3
1.1
140.00
116.46
pmol/l
—
7
61
82
864
0.94
0.17
1.3
1.2
120.50
139.30
u/ml
0.19
28
345
145
1398
1.05
0.17
3.3
3.4
7.39
7.39
ph
0.96
107
966
21
186
1.13
0.17
1.3
1.2
—
—
—
0
0
218
2122
1.04
0.17
2.4
2.9
23.53
26.33
u/l
1.53
212
2020
26
234
1.12
0.17
1.1
1.2
—
—
—
0
0
5
69
0.72
0.17
2.2
1.3
—
—
—
0
0
5
69
0.72
0.17
2.2
1.3
—
—
—
0
0
5
69
0.72
0.17
2.2
1.3
—
—
—
0
0
5
69
0.72
0.17
2.2
1.3
—
—
—
0
0
8
68
1.18
0.16
1.6
4.1
3.52
3.77
mmol/l
—
8
68
8
69
1.16
0.16
1.0
2.0
—
—
—
0
0
20
177
1.13
0.16
8.3
8.6
95.48
94.55
%
0.79
20
177
20
177
1.13
0.16
8.3
8.6
1.36
1.23
%
0.29
20
177
8
72
1.11
0.16
1.1
2.4
—
—
—
0
0
19
214
0.88
0.16
1.2
1.3
—
—
—
0
0
19
168
1.13
0.16
2.8
2.6
0.65
0.62
%
0.23
19
168
8
73
1.10
0.15
1.5
1.2
—
—
—
0
0
6
77
0.78
0.15
1.0
1.2
—
—
—
0
0
174
1792
0.96
0.15
2.0
2.1
2.32
2.45
mg/l
0.49
155
1567
235
2295
1.04
0.15
1.7
1.7
1.23
1.26
mmol/l
0.23
210
2063
9
79
1.14
0.15
1.0
1.0
195.11
193.10
mg/l
—
9
68
23
207
1.11
0.15
1.9
2.1
—
—
—
0
0
218
2128
1.04
0.14
3.6
4.1
38.10
37.25
g/l
1.71
209
2019
7
89
0.78
0.14
1.3
1.1
—
—
—
0
0
7
89
0.78
0.14
1.0
1.1
—
—
—
0
0
15
170
0.88
0.13
1.3
1.3
353.12
224.26
u/ml
—
8
116
54
510
1.06
0.13
1.9
2.4
—
—
—
0
0
52
550
0.94
0.13
1.8
1.8
—
—
—
0
0
9
107
0.84
0.13
1.3
2.5
24.39
24.41
mmol/l
—
9
100
30
277
1.09
0.13
2.7
2.2
71.97
75.19
e9/l
0.16
20
189
34
316
1.08
0.13
2.8
3.3
7.39
7.38
ph
0.19
15
172
73
763
0.95
0.12
1.1
1.2
—
—
—
0
0
226
2307
0.97
0.12
5.0
5.1
1.22
1.21
mmol/l
1.23
194
1985
34
318
1.07
0.11
2.8
3.5
5.95
5.74
kpa
0.73
34
310
31
332
0.93
0.11
6.6
6.7
7.43
7.42
ph
—
10
188
50
475
1.06
0.11
2.9
4.5
0.10
0.54
%
—
10
100
36
383
0.94
0.11
1.3
1.2
—
—
—
0
0
28
301
0.93
0.11
2.3
2.2
—
—
—
0
0
47
447
1.06
0.10
1.1
1.1
—
—
—
0
0
5
45
1.11
0.10
1.6
1.2
53.20
69.82
umol/l
—
5
45
106
1030
1.03
0.09
1.6
1.6
126596156.83
57112013.26
pmol/l
0.23
94
914
23
248
0.93
0.09
2.4
2.1
68.06
67.92
g/l
0.04
23
235
37
391
0.94
0.09
2.8
2.8
7.39
7.34
ph
2.91
28
277
47
448
1.05
0.09
5.6
5.7
104.94
105.03
mmol/l
0.05
47
448
5
47
1.06
0.09
1.4
2.2
195.20
209.20
e6/l
—
5
40
13
116
1.12
0.09
1.1
1.1
—
—
—
0
0
14
155
0.90
0.09
1.1
1.0
0.98
2.67
eliau/ml
—
5
77
14
126
1.11
0.09
1.1
1.1
—
—
—
0
0
18
165
1.09
0.09
3.8
2.0
—
—
—
0
0
6
56
1.07
0.08
1.0
1.2
6.83
7.36
mm/h
—
6
56
10
88
1.14
0.08
2.0
1.6
—
—
—
0
0
7
65
1.08
0.08
1.3
2.2
12.77
12.34
u/ml
—
7
65
23
215
1.07
0.07
1.8
2.4
5.09
5.12
kpa
0.08
23
206
149
1518
0.98
0.07
2.6
2.5
13.86
19.14
ng/l
0.53
57
556
50
481
1.04
0.07
2.8
4.7
0.11
0.10
%
—
9
93
7
84
0.83
0.07
1.3
1.1
—
—
—
0
0
9
85
1.06
0.07
1.7
3.9
1.21
1.40
mmol/l
—
9
85
18
167
1.08
0.07
1.4
1.4
—
—
—
0
0
8
94
0.85
0.06
1.9
1.4
—
—
—
0
0
36
376
0.96
0.06
1.2
1.1
0.80
0.82
g/l
0.29
36
376
28
267
1.05
0.05
2.8
4.1
2.21
9.38
ug/l
2.15
14
188
16
149
1.08
0.05
2.2
4.6
—
—
—
0
0
48
492
0.97
0.03
3.1
5.0
0.00
0.05
%
—
7
86
79
803
0.98
0.03
2.0
3.0
4.49
4.95
e9/l
0.41
65
744
33
321
1.03
0.02
1.3
1.7
0.23
0.21
mg/l
—
9
128
12
113
1.06
0.02
2.2
2.3
—
—
—
0
0
36
368
0.98
0.01
1.2
1.1
1.50
1.57
g/l
0.86
36
368
17
163
1.04
0.01
1.4
1.4
163.33
174.06
au/ml
—
6
40
64
648
0.99
0.01
2.6
3.0
—
—
—
0
0
202
2012
1.01
0.01
4.6
4.6
1.22
1.22
mmol/l
0.56
192
1872
67
663
1.01
0.01
1.7
1.9
—
—
—
0
0
15
144
1.04
0.00
1.3
1.3
—
—
—
0
0
21
204
1.03
0.00
2.0
2.8
134.43
132.64
g/l
0.22
21
197
66
666
0.99
0.00
1.7
1.9
—
—
—
0
0
66
666
0.99
0.00
1.7
1.9
—
—
—
0
0
24
235
1.02
0.00
1.5
1.4
15.05
13.93
u/l
0.08
19
206
10
97
1.03
0.00
1.1
1.4
—
91.23
—
0
6
33
335
0.98
0.00
6.5
6.6
4.77
4.98
kpa
0.96
33
322
33
335
0.98
0.00
6.5
6.6
13.64
13.81
kpa
0.06
33
322
17
173
0.98
0.00
1.2
1.4
—
—
—
0
0
18
177
1.02
0.00
1.2
1.3
365.78
392.35
mg/l
0.28
18
170
79
785
1.01
0.00
1.2
1.2
—
—
—
0
0
14
138
1.01
0.00
2.2
3.3
25.76
24.89
mmol/l
0.98
14
131
184
1845
1.00
0.00
7.1
5.9
1.08
1.06
inr
0.50
153
1518
29
288
1.01
0.00
6.7
7.1
97.18
96.22
%
0.93
29
282
16
161
0.99
0.00
1.2
1.3
3.99
3.55
mmol/l
0.73
16
153
62
622
1.00
0.00
1.7
1.9
—
—
—
0
0
50
501
1.00
0.00
2.8
4.6
1.22
0.71
%
—
9
113
67
671
1.00
0.00
1.7
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.4
—
58.81
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
99
0.91
-0.00
2.7
3.2
3.43
4.28
e9/l
—
9
99
0
7
0.00
-0.00
0.0
1.1
—
14.84
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
151.21
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
13.96
—
0
7
0
5
0.00
-0.00
0.0
2.4
—
1.16
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
57
0.88
-0.00
1.0
2.4
1356.40
1556.28
e6/l
—
5
50
0
9
0.00
-0.00
0.0
1.7
—
1.19
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
1.55
—
0
5
0
9
0.00
-0.00
0.0
1.3
—
10.60
—
0
9
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
139.40
—
0
5
0
6
0.00
-0.00
0.0
3.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
239.00
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
3.00
—
0
6
6
61
0.98
-0.00
1.2
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
381.60
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint O15_BREAST_LACT_OTHER_DIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_BREAST_LACT_OTHER_DIS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: O15_BREAST_LACT_OTHER_DIS – Other disorders of breast and lactation associated with childbirth

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data