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Other immunodeficiencies

DOID EFO Endpoint Browser PheWeb

D3_IMMUDEFOTHER

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D84
  • Cause of death: ICD-10 — D84

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

456

6. Filter based on genotype QC (FinnGen only)

408

Control definitions (FinnGen only)

Control exclude
D3_IMMUNEMECHANISM

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D80-D89
Name in latin
Aliae deficientiae immunales

Similar endpoints

↥

List of similar endpoints to Other immunodeficiencies based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2645 1656 973
Only index persons 2220 1431 789
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.03
Only index persons 0.04 0.05 0.03
Median age at first event (years)
Whole population 45.52 47.81 41.32
Only index persons 45.60 47.13 42.83

-FinnGen-

Key figures

All Female Male
Number of individuals 408 279 129
Unadjusted period prevalence (%) 0.09 0.10 0.06
Median age at first event (years) 48.36 46.21 53.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
427
Matched controls
4270
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D84.18
ICD-10 Finland
Other specified defect in the complement system
+∞
131.2
119
*
D84.9
ICD-10 Finland
Immunodeficiency, unspecified
+∞
117.2
107
*
T78.3
ICD-10 Finland
Angioneurotic oedema
43.9
114.9
70
19
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
13.3
87.5
91
85
D84.1
ICD-10 Finland
Defects in the complement system
+∞
80.8
75
*
D84.19
ICD-10 Finland
Unspecified defect in the complement system
+∞
71.9
67
*
WW200
NOMESCO Finland
Immunization
18.6
65.3
54
33
H02AB06
ATC
prednisolone; systemic
5.5
59.1
312
1411
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
10.3
58.7
71
81
ZX120
NOMESCO Finland
Intravenous
6.4
55.2
109
217
TDM10
NOMESCO Finland
Puncture of maxillary antrum
9.9
54.8
68
80
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
6.8
54.5
99
181
D84.8
ICD-10 Finland
Other specified immunodeficiencies
+∞
52.2
49
*
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
14.5
50.2
47
36
R03DC03
ATC
montelukast; oral
4.7
49.5
158
473
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
10.2
48.3
58
65
J01MA14
ATC
moxifloxacin; systemic
6.2
47.5
94
186
C01CA24
ATC
epinephrine; parenteral
6.1
47.4
95
190
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.4
47.1
288
1370
H02AB07
ATC
prednisone; oral
5.3
46.6
114
273
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
45.6
43
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.0
43.9
198
754
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
43.5
41
*
J01MA12
ATC
levofloxacin; systemic
4.5
42.5
138
413
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
42.4
40
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
41.3
39
*
XQ800
NOMESCO Finland
Prick test
5.6
40.6
88
188
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.6
40.3
121
340
D84.11
ICD-10 Finland
Hereditary angioedema type I
+∞
40.2
38
*
338
Kela drug reimbursment
C1-esterase inhibitor, icatibant and conestat alfa
+∞
39.2
37
*
D84.13
ICD-10 Finland
Hereditary angioedema type III
+∞
39.2
37
*
J45.9
ICD-10 Finland
Asthma, unspecified
4.0
39.0
152
516
UGC12
NOMESCO Finland
Flexible bronchoscopy
6.9
38.9
66
111
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
6.8
38.0
65
110
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
37.0
35
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.8
36.3
156
563
B06AC02
ATC
icatibant; parenteral
+∞
35.9
34
*
D84.0
ICD-10 Finland
Lymphocyte function antigen-1 [LFA-1] defect
+∞
35.9
34
*
J45.0
ICD-10 Finland
Predominantly allergic asthma
4.8
35.1
94
239
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.8
34.7
147
523
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.8
34.0
69
138
UJF32
NOMESCO Finland
Coloscopy
3.6
33.4
160
615
J45.1
ICD-10 Finland
Nonallergic asthma
5.1
32.6
77
176
H02AB04
ATC
methylprednisolone; systemic
4.2
32.3
106
314
R03BB04
ATC
tiotropium bromide; inhalant
5.2
31.8
74
167
UDH02
NOMESCO Finland
Rhinopharyngoscopy
5.2
31.7
73
163
J01FF01
ATC
clindamycin; systemic
3.2
29.4
169
717
TGC00
NOMESCO Finland
Bronchial lavation
11.1
29.2
32
31
R50.9
ICD-10 Finland
Fever, unspecified
3.6
28.6
122
430
J45.8
ICD-10 Finland
Mixed asthma
8.3
28.5
39
51
UJF30
NOMESCO Finland
Ileoscopy through colon
4.4
28.2
81
216
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.3
28.2
152
619
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
27.4
26
*
UJF92
NOMESCO Finland
Capsular endoscopy
10.4
27.1
31
32
R03AK06
ATC
salmeterol and fluticasone; inhalant
3.7
27.0
107
358
X59
ICD-10 Finland
Exposure to unspecified factor
3.3
26.9
135
524
Z01.8
ICD-10 Finland
Other specified special examinations
3.2
26.9
147
601
H02AB09
ATC
hydrocortisone; systemic
7.7
26.7
39
55
B02AA02
ATC
tranexamic acid; systemic
3.4
25.8
120
444
R60.9
ICD-10 Finland
Oedema, unspecified
5.6
25.2
51
101
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.7
24.4
61
145
J31.0
ICD-10 Finland
Chronic rhinitis
4.0
24.2
79
230
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.9
24.2
180
865
J01MA02
ATC
ciprofloxacin; systemic
2.8
23.8
199
1014
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.1
23.7
72
199
R03DA04
ATC
theophylline; systemic, rectal
6.3
22.7
40
69
R03AK08
ATC
formoterol and beclometasone; inhalant
5.4
22.1
46
93
R06.0
ICD-10 Finland
Dyspnoea
2.8
22.0
155
717
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
6.0
21.3
39
70
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.6
21.2
215
1189
J45
ICD-10 Finland
Asthma
3.6
20.9
78
248
6BA02, ,
NOMESCO Finland
44.2
20.7
25
6
A07AA02
ATC
nystatin; oral
5.0
20.4
47
104
J47
ICD-10 Finland
Bronchiectasis
18.5
20.3
31
18
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.8
20.3
69
206
J01FA06
ATC
roxithromycin; oral
2.6
20.3
208
1151
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.9
20.0
64
183
Z3231
NOMESCO Finland
Registered nurse
2.6
19.9
166
829
R06AE09
ATC
levocetirizine; oral
3.1
19.9
104
406
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.6
19.7
75
241
R06AE07
ATC
cetirizine; oral
2.5
19.7
241
1441
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.4
19.6
80
269
Z31.5
ICD-10 Finland
Genetic counselling
3.9
19.4
62
177
R03AC02
ATC
salbutamol; inhalant
2.7
19.4
300
2000
R03AC12
ATC
salmeterol; inhalant
5.5
19.2
39
77
R01AD08
ATC
fluticasone; nasal
2.6
18.8
169
871
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.6
18.8
160
804
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
4.8
18.7
44
99
R03BA08
ATC
ciclesonide; inhalant
3.7
18.7
66
202
Z3226
NOMESCO Finland
Physiotherapist
2.8
18.2
119
523
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.6
18.2
68
216
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
5.0
18.2
41
89
XG410
NOMESCO Finland
Flow-volume spirometry
5.7
18.1
35
66
J46
ICD-10 Finland
Status asthmaticus
7.1
18.1
28
42
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.7
18.0
44
102
T78.4
ICD-10 Finland
Allergy, unspecified
4.5
17.9
46
111
A02BC01
ATC
omeprazole; systemic
2.6
17.9
147
723
XF400
NOMESCO Finland
ECG with 12 standard connections
3.0
17.9
92
355
C03CA01
ATC
furosemide; systemic
2.7
17.8
130
603
B06AC05
ATC
lanadelumab; parenteral
+∞
17.8
17
*
D84.12
ICD-10 Finland
Hereditary angioedema type II
+∞
17.8
17
*
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
6.9
17.7
28
43
ZXE10
NOMESCO Finland
More than one and less than three hours
2.4
17.7
189
1049
N03AX16
ATC
[U] pregabalin
2.6
17.1
124
572
R06AX27
ATC
desloratadine; oral
2.4
17.0
179
983
R03AK07
ATC
formoterol and budesonide; inhalant
2.6
16.9
128
603
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.6
16.8
123
569
A06AD11
ATC
lactulose; oral
3.2
16.8
77
277
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.4
16.8
44
108
Z2221
NOMESCO Finland
Medical doctor
2.4
16.8
162
855
J32.4
ICD-10 Finland
Chronic pansinusitis
15.1
16.5
27
19
R60.0
ICD-10 Finland
Localized oedema
3.1
16.4
77
281
A02BC02
ATC
pantoprazole; systemic
2.5
16.4
306
2145
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
5.9
16.3
30
54
L04AX01
ATC
azathioprine; systemic
5.0
16.2
36
77
ZXD10
NOMESCO Finland
Scheduled procedure
2.3
15.9
194
1128
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
7.2
15.9
24
35
Z2446
NOMESCO Finland
Social worker
3.4
15.8
61
197
R03BA02
ATC
budesonide; inhalant
2.6
15.8
113
516
L01BA01
ATC
methotrexate; systemic
5.9
15.8
29
52
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
15.7
145
746
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.3
15.6
274
1850
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.6
15.6
39
92
ZXA10
NOMESCO Finland
Bilateral
2.6
15.4
107
481
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.1
15.4
45
120
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.7
15.4
100
435
ZXE00
NOMESCO Finland
One hour or less
2.3
15.3
205
1233
N02AX02
ATC
tramadol; systemic, rectal
2.3
15.3
200
1191
A01AB09
ATC
miconazole; local oral
3.6
15.1
54
166
N06AX21
ATC
duloxetine; oral
2.9
15.0
80
313
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.2
14.9
67
238
WZC30
NOMESCO Finland
Teaching
2.7
14.8
96
416
R01AD09
ATC
mometasone; nasal
2.2
14.5
238
1546
P01BA02
ATC
hydroxychloroquine; oral
3.4
14.4
55
176
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
20.0
14.4
21
11
X57
ICD-10 Finland
Unspecified privation
6.0
14.3
26
46
R01AD05
ATC
budesonide; nasal
3.6
14.2
51
157
R03BA05
ATC
fluticasone; inhalant
2.4
13.9
119
588
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
4.6
13.8
34
79
A02BC03
ATC
lansoprazole; oral
2.3
13.8
139
737
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
13.7
86
366
L04AB04
ATC
adalimumab; parenteral
6.1
13.7
24
41
SPAT1255
SPAT
Intravenous administration of medicine
4.1
13.7
39
102
L50.8
ICD-10 Finland
Other urticaria
6.3
13.5
23
38
R03BB01
ATC
ipratropium bromide; inhalant
4.9
13.3
30
65
N02AA05
ATC
oxycodone; systemic
2.6
13.0
85
368
ZYC01
NOMESCO Finland
Remote contact by phone
3.4
12.8
49
157
A02BA03
ATC
famotidine; systemic
5.7
12.7
24
44
R4120
NOMESCO Finland
Occupational therapy
3.3
12.7
50
163
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.4
12.6
113
566
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
5.3
12.6
26
52
B06AC01
ATC
c1-inhibitor, plasma derived; parenteral
+∞
12.6
12
*
C10AC01
ATC
colestyramine; oral
5.6
12.4
24
45
C08DA01
ATC
verapamil; systemic
4.5
12.4
31
73
B34.9
ICD-10 Finland
Viral infection, unspecified
4.7
12.3
29
65
R03AC03
ATC
terbutaline; inhalant
2.6
12.2
78
334
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.6
12.1
41
121
XW000
NOMESCO Finland
Bone marrow biopsy
4.6
12.1
29
66
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
4.3
12.1
32
79
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
3.8
12.0
38
107
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
12.0
88
402
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.5
12.0
89
409
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.1
11.8
150
864
E0000UV, ,
ATC
2.0
11.8
206
1336
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
19.6
11.7
17
9
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.3
11.6
104
519
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
5.2
11.6
24
48
R4110
NOMESCO Finland
Physiotherapy
2.1
11.5
145
831
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.8
11.5
64
255
R75
ICPC
Sinusitis acute/chronic
3.5
11.3
40
122
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.2
11.2
46
154
L50.9
ICD-10 Finland
Urticaria, unspecified
3.8
11.2
35
98
R01AD58
ATC
fluticasone, combinations; nasal
2.1
11.1
137
777
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
4.7
11.1
26
58
ZXA05
NOMESCO Finland
Left side
2.2
11.0
114
604
ZXD05
NOMESCO Finland
Urgent procedure
2.1
11.0
152
900
L04AA06
ATC
mycophenolic acid; systemic
8.6
10.9
23
28
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.2
10.9
44
146
J01FA09
ATC
clarithromycin; systemic
2.1
10.8
156
936
GD1AD
NOMESCO Finland
Thorax CT examination
3.6
10.8
37
110
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
5.8
10.8
20
36
M05BA04
ATC
alendronic acid; oral
3.4
10.7
40
126
J01DC02
ATC
cefuroxime; systemic
3.5
10.7
38
116
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
8.9
10.7
22
26
XG474
NOMESCO Finland
Exhalation nntrogen oxide
4.7
10.6
25
56
R03BA01
ATC
beclometasone; inhalant
2.5
10.6
74
329
JN3AD
NOMESCO Finland
Abdominal CT examination
2.6
10.6
69
297
WX002
NOMESCO Finland
Sedation and analgesia
2.3
10.6
91
445
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
10.5
10
*
D86.0
ICD-10 Finland
Sarcoidosis of lung
+∞
10.5
10
*
NFC20
NOMESCO Finland
Secondary implantation of hip prosthesis
12.5
10.4
18
15
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.6
10.4
63
262
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
19.4
10.3
15
8
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.3
10.3
27
66
WZC00
NOMESCO Finland
Treatment plan or consultation
2.0
10.3
181
1161
C07AB07
ATC
bisoprolol; oral
2.0
10.3
190
1240
R06AX22
ATC
ebastine; oral
2.3
10.3
95
479
A02BA02
ATC
ranitidine; systemic
2.3
10.2
87
423
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
5.5
10.2
20
38
J01DA01
ATC
[U] cefalexin
2.0
10.2
273
2017
B01AB05
ATC
enoxaparin; parenteral
2.1
10.1
136
792
A06AC01
ATC
ispaghula (psylla seeds); oral
2.1
10.0
121
677
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.3
10.0
26
63
J01FA10
ATC
azithromycin; systemic
2.0
10.0
282
2113
J05AB11
ATC
valaciclovir; oral
2.3
10.0
86
420
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.2
9.9
40
132
P01AB01
ATC
metronidazole; oral, rectal
1.9
9.9
193
1278
ZXE20
NOMESCO Finland
More than three and less than five hours
2.5
9.9
71
320
C03DA01
ATC
spironolactone; oral
2.7
9.9
58
237
A07EC02
ATC
mesalazine; oral, rectal
3.5
9.8
34
102
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
4.4
9.8
25
60
R01AD12
ATC
fluticasone furoate; nasal
2.0
9.7
162
1016
R03AK11
ATC
formoterol and fluticasone; inhalant
5.5
9.7
19
36
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.5
9.7
66
290
SPAT1229
SPAT
Assessment of need for aid
3.4
9.7
35
108
J01DA06
ATC
[U] cefuroxime
2.3
9.7
79
377
M54.4
ICD-10 Finland
Lumbago with sciatica
2.2
9.6
99
520
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
9.4
9.6
19
21
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.8
9.6
52
204
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.1
9.5
42
147
ZX108
NOMESCO Finland
Inhalation
18.0
9.5
14
8
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.5
9.4
23
53
J01AA02
ATC
doxycycline; systemic
2.1
9.4
331
2650
D89.89
ICD-10 Finland
Other specified disorders involving the immune mechanism, not elsewhere classified
+∞
9.4
9
*
D80.2
ICD-10 Finland
Selective deficiency of immunoglobulin A [IgA]
+∞
9.4
9
*
N03AX12
ATC
[U] gabapentin; oral
2.3
9.4
82
403
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.9
9.3
28
76
R04
ICPC
Breathing problem other
3.9
9.3
28
76
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
14.1
9.2
15
11
G47.3
ICD-10 Finland
Sleep apnoea
2.1
9.2
105
573
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.8
9.1
28
77
A03FA02
ATC
cisapride; oral, rectal
3.2
9.1
38
128
A07AA09
ATC
vancomycin; oral
10.4
9.1
17
17
R51.80
ICD-10 Finland
Headache
2.1
9.0
100
540
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
19.1
9.0
13
7
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
2.8
8.9
46
175
R03AC13
ATC
formoterol; inhalant
3.6
8.9
30
88
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
4.6
8.9
21
47
R96
ICPC
Asthma
2.6
8.9
55
230
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
7.4
8.8
20
28
ZY010
NOMESCO Finland
Hospital outpatient
3.0
8.8
40
142
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
3.0
8.8
40
142
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.4
8.8
22
52
WX722
NOMESCO Finland
PEEP
3.8
8.7
27
75
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.0
8.6
39
138
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.8
8.6
45
173
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
8.6
109
618
A07EA06
ATC
budesonide; oral, local oral
3.6
8.5
28
81
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
3.5
8.5
29
86
S97
ICPC
Chronic ulcer skin
3.2
8.5
34
112
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.4
8.5
62
281
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
5.0
8.4
18
37
M54.3
ICD-10 Finland
Sciatica
3.2
8.4
34
113
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
+∞
8.4
8
*
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
+∞
8.4
8
*
E84.0
ICD-10 Finland
Cystic fibrosis with pulmonary manifestations
+∞
8.4
8
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
8.4
103
577
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
8.3
191
1312
M25.5
ICD-10 Finland
Pain in joint
1.9
8.3
161
1050
XG466
NOMESCO Finland
Sleep oxymetry
4.7
8.2
19
42
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.8
8.1
43
166
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
2.7
8.1
45
178
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
34.0
8.1
10
*
K50.9
ICD-10 Finland
Crohn disease, unspecified
6.5
8.1
20
32
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.9
8.1
132
813
Z3229
NOMESCO Finland
Other healthcare associate professional
2.6
8.1
49
203
Q79.6
ICD-10 Finland
Ehlers-Danlos syndrome
22.5
8.1
11
5
N06AA09
ATC
amitriptyline; systemic
2.6
8.0
47
192
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
6.8
8.0
19
29
R06AX26
ATC
fexofenadine; oral
2.7
8.0
44
174
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.8
7.9
263
2006
R03AK03
ATC
[U] fenoterol and ipratropium bromide
3.6
7.9
26
75
WVA20, ,
SPAT
3.6
7.9
26
75
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
13.4
7.9
13
10
N05BB01
ATC
hydroxyzine; systemic
3.1
7.9
34
117
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.2
7.9
69
338
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
11.1
7.8
14
13
DMB00
NOMESCO Finland
Endonasal trephine of maxillary antrum
11.1
7.8
14
13
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.0
7.8
106
613
N05CF01
ATC
zopiclone; oral
1.9
7.8
137
864
7151E
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, LONKKANIVEL]
45.8
7.7
9
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.5
7.7
52
227
A04AA01
ATC
ondansetron; systemic, rectal
2.7
7.7
44
177
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.5
7.7
51
221
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.5
7.6
26
77
9294
FHL
Endoprosthesis replacement of the entire hip joint (eg Charnley)
18.8
7.6
11
6
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
18.8
7.6
11
6
M35.7
ICD-10 Finland
Hypermobility syndrome
6.4
7.6
19
31
E000001, ,
ATC
2.0
7.6
97
548
Y84
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
12.1
7.6
13
11
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
3.2
7.6
30
98
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
10.3
7.6
14
14
N05CD07
ATC
temazepam; oral
2.6
7.6
47
197
A02BC05
ATC
esomeprazole; systemic
1.8
7.5
177
1215
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.4
7.5
19
45
J33.0
ICD-10 Finland
Polyp of nasal cavity
4.4
7.5
19
45
Z2445
NOMESCO Finland
Psychologist
2.9
7.5
35
126
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
4.0
7.5
21
54
J02AC01
ATC
fluconazole; systemic
1.8
7.5
187
1307
M01AE03
ATC
ketoprofen; systemic, rectal
1.8
7.5
149
974
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
7.5
179
1236
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.0
7.5
34
121
J01DB01
ATC
cefalexin; oral
2.1
7.4
357
3029
S01GX01
ATC
cromoglicic acid; ophthalmic
1.9
7.4
105
615
N03AE01
ATC
clonazepam; systemic
3.1
7.4
31
105
M79.7
ICD-10 Finland
Fibromyalgia
3.4
7.4
26
79
R03DC01
ATC
zafirlukast; oral
7.0
7.4
17
25
XCK00
NOMESCO Finland
Perimetry
3.2
7.3
30
100
WX402
NOMESCO Finland
General anaesthesia
1.9
7.3
115
697
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.5
7.3
49
213
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
+∞
7.3
7
*
E84.9
ICD-10 Finland
Cystic fibrosis, unspecified
+∞
7.3
7
*
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
7.3
7
*
2776B
ICD-9 Finland
Other and unspecified disorders of metabolism, Other deficiencies of circulating enzymes[OEDEMA ANGIONEUROTICUM HEREDITARIUM (HANE)]
+∞
7.3
7
*
A46
ICD-10 Finland
Erysipelas
2.3
7.3
61
293
ZX112
NOMESCO Finland
Subcutaneous
4.4
7.3
18
42
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.7
7.2
23
65
JN4BD
NOMESCO Finland
Extensive body CT
2.5
7.2
46
195
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
30.6
7.2
9
*
W84
ICD-10 Finland
Unspecified threat to breathing
30.6
7.2
9
*
K07.60
ICD-10 Finland
Snapping jaw
2.7
7.2
39
153
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
20.4
7.2
10
5
4AA12, ,
NOMESCO Finland
20.4
7.2
10
5
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
8.1
7.2
15
19
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
6.2
7.1
18
30
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
7.1
122
759
L04AX03
ATC
methotrexate; systemic
2.4
7.1
50
222
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.1
7.1
71
366
H02BX01
ATC
methylprednisolone, combinations; systemic
3.6
7.1
23
66
ZXA00
NOMESCO Finland
Right side
1.9
7.1
111
672
N02AC04
ATC
dextropropoxyphene; oral
4.0
7.1
20
52
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.3
7.0
56
263
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.2
7.0
66
332
T78.2
ICD-10 Finland
Anaphylactic shock, unspecified
6.5
7.0
17
27
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
3.8
7.0
21
57
D07AC01
ATC
betamethasone; topical
1.8
7.0
154
1033
XA800
NOMESCO Finland
Neuropsychological investigation
2.9
7.0
33
120
N06AX03
ATC
mianserin; oral
3.3
7.0
26
82
A03FA01
ATC
metoclopramide; systemic, rectal
1.9
7.0
107
643
R53
ICD-10 Finland
Malaise and fatigue
1.8
6.9
122
765
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
6.9
6.9
16
24
R4190
NOMESCO Finland
Nutritional therapy
2.9
6.9
33
121
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
6.8
118
735
L04AA01
ATC
[U] ciclosporin
9.5
6.8
13
14
R06AX13
ATC
loratadine; oral
2.1
6.8
75
401
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
1.9
6.8
103
616
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
40.7
6.8
8
*
NFC40
NOMESCO Finland
Repair of hip prosthesis by bone transplant to acetabulum
40.7
6.8
8
*
C07AB02
ATC
metoprolol; systemic
2.1
6.8
75
402
SPF20
NOMESCO Finland
Temporary relining of dentures
17.0
6.8
10
6
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
6.8
186
1325
M04AA01
ATC
allopurinol; systemic
2.4
6.8
47
208
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.3
6.8
55
261
R01BA52
ATC
pseudoephedrine, combinations; oral
1.8
6.7
133
863
R1250
NOMESCO Finland
Evaluation of functional capability
3.8
6.7
20
54
UKC02
NOMESCO Finland
Cystoscopy
2.2
6.7
61
303
127
Kela drug reimbursment
Transplant complication
6.6
6.7
16
25
N02BE01
ATC
paracetamol; systemic, rectal
2.2
6.7
373
3252
N30.0
ICD-10 Finland
Acute cystitis
2.0
6.6
81
450
J01DA08
ATC
[U] cefaclor
2.2
6.6
56
270
DHB50
NOMESCO Finland
Turbinoplasty
3.9
6.6
19
50
B01AB04
ATC
dalteparin; parenteral
3.2
6.6
26
85
J96.1
ICD-10 Finland
Chronic respiratory failure
7.0
6.6
15
22
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
7.0
6.6
15
22
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
3.3
6.5
24
75
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.4
6.5
44
192
R42
ICD-10 Finland
Dizziness and giddiness
1.9
6.5
96
568
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.8
6.5
32
119
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.3
6.5
52
245
A08
ICPC
Swelling
2.9
6.5
30
108
Z71.8
ICD-10 Finland
Other specified counselling
1.7
6.5
165
1149
J01XB01
ATC
colistin; inhalant, parenteral
70.9
6.4
7
*
A01AB10
ATC
natamycin; local oral
3.9
6.4
19
51
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.9
6.4
19
51
R02
ICPC
Shortness of breath/dyspnoea
2.1
6.4
64
330
KA1AE
NOMESCO Finland
Kidney ultrasound examination
5.3
6.4
18
35
N05BA01
ATC
diazepam; systemic, rectal
2.1
6.4
63
323
J20
ICD-10 Finland
Acute bronchitis
2.2
6.4
58
288
K50.8
ICD-10 Finland
Other Crohn disease
6.1
6.4
16
27
K50.0
ICD-10 Finland
Crohn disease of small intestine
6.1
6.4
16
27
R01BA51
ATC
phenylpropanolamine, combinations; oral
2.2
6.3
56
275
3AC01, ,
NOMESCO Finland
11.3
6.3
11
10
ZXH09, ,
SPAT
4.0
6.3
18
47
WX892
NOMESCO Finland
Monitored bed care
2.6
6.3
38
157
N06AX11
ATC
mirtazapine; oral
1.7
6.3
149
1014
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.4
6.3
44
195
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.2
6.3
58
290
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
7.2
6.3
14
20
D82.4
ICD-10 Finland
Hyperimmunoglobulin E [IgE] syndrome
+∞
6.3
6
*
132
Kela drug reimbursment
Sarcoidosis
+∞
6.3
6
*
R05CB13
ATC
dornase alfa (desoxyribonuclease); inhalant
+∞
6.3
6
*
E84.1
ICD-10 Finland
Cystic fibrosis with intestinal manifestations
+∞
6.3
6
*
D84.14
ICD-10 Finland
C1 esterase inhibitor deficiency (C1-INH deficiency)
+∞
6.3
6
*
304
Kela drug reimbursment
Dornase alfa
+∞
6.3
6
*
D02AX
ATC
Other emollients and protectives
3.1
6.2
26
88
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.6
6.2
37
152
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
6.4
6.2
15
24
SAA04
NOMESCO Finland
Special examination of mouth
2.6
6.2
36
146
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
7.8
6.2
13
17
TAB00
NOMESCO Finland
Lumbar puncture
2.8
6.2
30
111
K92.1
ICD-10 Finland
Melaena
3.2
6.1
24
78
FP1B5
NOMESCO Finland
Resting ECG, 12 leads
4.2
6.1
16
39
A09AA02
ATC
multienzymes (lipase, protease etc.); oral
4.2
6.1
16
39
A07EC01
ATC
sulfasalazine; oral, rectal
2.6
6.1
37
153
NF1AA
NOMESCO Finland
Hip X-ray examination
2.6
6.1
37
153
A01
ICPC
Pain general/multiple sites
2.2
6.1
53
258
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
3.7
6.1
19
53
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.0
6.1
65
344
D07AB02
ATC
hydrocortisone butyrate; topical
1.7
6.0
129
852
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.2
6.0
51
246
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.2
6.0
24
79

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
205
320
11.40
139.98
9.0
2.6
9.37
10.01
g/l
1.14
200
295
186
263
11.76
136.94
4.3
1.7
1.33
1.32
g/l
0.03
175
244
92
38
30.58
133.47
2.8
1.7
1466.72
1443.93
e6/l
0.04
81
27
91
37
30.98
132.73
2.4
1.3
—
—
—
0
0
86
38
28.09
121.38
2.4
1.3
0.32
0.36
g/l
0.47
71
32
86
38
28.09
121.38
2.4
1.3
5.29
6.61
g/l
1.90
72
32
86
38
28.09
121.38
2.4
1.3
2.65
2.73
g/l
0.09
72
31
62
11
65.77
111.50
3.8
1.2
643.34
1103.55
u/ml
0.75
62
11
77
33
28.25
109.61
2.6
1.8
215.07
192.87
e6/l
0.27
67
23
96
69
17.66
108.39
2.4
2.4
0.67
0.89
g/l
0.36
80
63
175
303
9.09
106.53
2.4
1.2
287.00
275.39
u/ml
0.03
169
280
67
21
37.66
105.57
2.6
1.6
0.28
0.32
e9/l
—
51
7
75
34
26.55
104.39
2.6
1.7
607.27
684.09
e6/l
0.21
64
22
286
1294
4.66
51.72
15.2
6.8
—
—
—
0
0
46
42
12.15
44.04
6.4
1.9
—
—
—
0
0
353
2004
5.39
44.00
17.8
6.7
0.04
0.04
e9/l
0.10
339
1702
352
1999
5.33
43.72
17.8
6.6
0.57
0.56
e9/l
0.74
338
1703
353
2038
5.22
42.11
17.9
6.7
2.03
2.02
e9/l
0.03
341
1791
38
28
14.80
41.30
2.0
2.5
41.38
43.08
%
0.14
27
12
354
2073
5.14
40.77
18.4
7.1
0.20
0.19
e9/l
0.48
342
1801
118
333
4.51
38.94
4.8
3.2
0.23
0.22
g/l
0.31
112
318
226
1001
3.67
38.86
3.8
1.5
1.84
2.23
g/l
3.00
192
601
357
2240
4.62
34.00
20.8
10.1
4.01
3.95
e9/l
0.22
344
1924
154
588
3.53
32.32
2.2
1.4
427.59
517.56
titre
0.33
29
131
198
887
3.30
31.96
7.7
4.0
—
—
—
0
0
123
416
3.75
30.92
3.2
2.2
349.82
379.00
nmol/l
0.78
118
393
140
520
3.52
30.44
3.8
1.9
—
—
—
0
0
302
1783
3.37
29.56
22.6
10.8
0.00
0.00
e9/l
0.78
260
1421
62
129
5.45
29.09
1.5
1.3
—
—
—
0
0
120
425
3.54
27.84
3.3
1.6
—
—
—
0
0
221
1175
2.83
24.58
11.3
6.4
—
—
—
0
0
127
506
3.15
23.92
3.9
2.7
20.64
22.39
%
0.89
122
472
139
591
3.00
23.28
4.0
2.6
12.43
13.53
umol/l
1.11
134
547
132
547
3.05
23.13
3.9
2.6
2.36
2.39
g/l
0.22
125
499
67
180
4.23
22.89
2.8
2.0
7.25
5.04
iu/ml
0.30
19
42
266
1616
2.71
21.86
16.2
7.7
1.20
1.22
mmol/l
3.17
257
1499
34
52
7.02
21.62
4.4
3.3
4.19
4.36
e9/l
0.16
34
52
92
322
3.37
21.28
6.8
5.4
0.75
0.83
%
0.13
38
103
180
914
2.68
21.15
10.3
4.9
—
—
—
0
0
251
1508
2.61
20.68
11.0
5.1
36.00
36.49
g/l
0.72
243
1433
59
156
4.23
20.51
1.5
1.2
0.38
3.86
u/ml
—
12
7
268
1667
2.63
20.45
4.4
2.8
75.87
75.80
nmol/l
0.01
254
1520
88
308
3.34
20.29
6.4
5.1
0.35
0.49
%
0.43
34
91
280
1785
2.65
20.20
14.5
7.9
1.21
1.22
mmol/l
1.15
256
1566
186
978
2.60
20.13
4.6
2.4
2.74
2.84
mg/l
0.22
175
855
86
300
3.34
19.92
3.3
3.3
82.18
74.13
e9/l
1.01
58
209
114
471
2.94
19.74
3.2
1.4
—
—
—
0
0
195
1065
2.53
19.28
8.7
4.2
7.40
7.40
ph
1.03
135
718
290
1910
2.62
19.06
12.0
6.5
10.94
11.92
umol/l
0.49
279
1815
370
2765
3.53
19.06
20.1
7.8
80.46
81.67
u/l
0.21
362
2619
116
494
2.85
18.91
11.4
7.3
1.08
1.10
mmol/l
0.36
111
458
191
1043
2.50
18.77
5.6
3.2
0.50
0.37
e6/l
0.15
151
743
31
50
6.61
18.73
2.7
1.5
—
—
—
0
0
31
50
6.61
18.73
2.7
1.5
—
—
—
0
0
31
50
6.61
18.73
2.7
1.5
—
—
—
0
0
31
50
6.61
18.73
2.7
1.5
—
—
—
0
0
211
1208
2.48
18.68
6.1
3.3
60.78
107.36
e6/l
0.30
173
904
26
36
7.63
17.99
3.3
1.1
1.21
3.99
u/ml
0.48
21
18
67
213
3.54
17.86
4.3
2.6
—
—
—
0
0
59
173
3.80
17.72
3.5
3.5
20.79
21.37
s
0.42
52
157
85
315
3.12
17.68
7.2
5.8
0.00
0.15
%
0.74
30
80
49
126
4.26
17.61
1.2
1.2
—
—
—
0
0
83
305
3.14
17.51
7.1
5.5
0.03
0.11
%
0.74
29
84
32
58
5.88
17.22
1.6
2.0
—
—
—
0
0
231
1424
2.36
16.74
7.6
4.1
94.31
82.95
e6/l
0.07
180
959
302
2101
2.49
16.47
11.1
5.3
6.41
6.51
mmol/l
0.47
294
1964
143
718
2.49
16.44
4.9
2.8
506.56
535.68
mosm/kgh2o
0.95
135
627
101
431
2.76
16.17
4.6
3.6
6.63
6.79
umol/l
0.03
89
380
20
6
34.86
15.87
3.3
1.7
26.20
26.67
%
—
20
6
165
901
2.35
15.58
4.1
3.3
1181.61
1055.31
ng/l
0.20
145
755
86
346
2.86
15.33
8.6
9.3
0.98
0.75
mmol/l
0.20
71
289
100
437
2.68
15.20
15.3
8.4
104.25
104.53
mmol/l
0.20
100
437
87
354
2.83
15.17
8.9
9.2
7.42
7.41
ph
0.67
41
192
150
799
2.35
14.88
5.3
2.6
3.66
6.35
e6/l
3.53
144
726
92
393
2.71
14.58
3.0
1.4
—
—
—
0
0
81
324
2.85
14.55
8.6
9.4
95.12
95.15
%
0.02
76
314
38
93
4.39
14.51
4.1
2.6
60.09
57.60
%
0.54
38
93
124
620
2.41
14.09
4.2
3.2
1.89
2.61
e6/l
0.72
72
299
155
857
2.27
13.92
2.8
2.0
0.89
1.21
mg/l
1.15
135
664
82
343
2.72
13.47
15.9
10.9
—
—
—
0
0
84
357
2.68
13.37
9.1
9.0
11.46
12.55
kpa
1.19
79
345
84
357
2.68
13.37
9.1
9.0
5.09
5.12
kpa
0.08
79
344
126
653
2.32
13.07
4.0
3.0
0.93
0.83
e6/l
0.14
75
329
175
1041
2.15
12.90
3.9
2.1
114.82
187.64
u/l
4.24
169
998
114
574
2.35
12.59
4.8
2.6
104.96
92.38
ug/g
0.20
101
463
152
866
2.17
12.42
2.1
2.1
—
—
—
0
0
26
53
5.16
12.32
1.2
1.2
—
—
—
0
0
28
61
4.84
12.30
4.5
2.5
—
—
—
0
0
29
66
4.64
12.10
1.2
1.2
3.54
3.25
u/ml
0.08
13
32
167
995
2.11
12.09
1.8
1.6
20.97
20.71
nmol/l
0.08
151
851
79
346
2.57
11.76
2.9
2.4
30.51
33.17
u/l
0.23
72
287
88
406
2.47
11.74
12.7
6.4
7.38
7.38
ph
0.34
50
236
270
1940
2.07
11.51
5.1
3.2
104.41
95.02
ug/l
0.46
263
1828
151
886
2.09
11.22
5.3
2.9
338.92
329.67
umol/l
0.52
145
797
71
304
2.60
11.03
7.4
5.9
7.41
7.41
ph
0.02
64
247
42
136
3.32
10.77
2.0
2.2
1.30
1.44
g/l
0.45
33
127
118
642
2.16
10.60
3.8
3.5
365.34
534.58
ng/l
0.25
67
446
82
387
2.38
10.33
13.3
6.5
1.79
1.71
mmol/l
0.09
74
322
86
419
2.32
10.06
1.6
1.4
—
—
—
0
0
231
1621
1.93
9.96
5.5
3.4
6.19
6.19
ph
0.02
122
902
35
107
3.47
9.81
2.4
2.8
4.39
2.17
index
0.54
23
58
32
94
3.60
9.52
1.2
1.1
—
—
—
0
0
32
94
3.60
9.52
1.2
1.1
—
—
—
0
0
213
1472
1.89
9.46
18.4
9.8
1.17
1.16
inr
0.11
181
1207
187
1239
1.91
9.46
5.2
3.2
2.33
2.36
mmol/l
3.10
177
1138
188
1249
1.90
9.42
5.6
3.4
20.72
31.53
ng/l
1.64
125
787
31
92
3.56
9.08
1.6
1.7
—
—
—
0
0
28
78
3.77
8.99
2.8
1.9
129.36
132.74
g/l
0.30
22
58
89
461
2.18
8.91
3.5
3.1
4.54
6.49
e9/l
0.77
84
411
25
65
4.02
8.82
1.1
1.1
—
—
—
0
0
172
1134
1.87
8.65
3.9
2.4
54.84
65.82
u/l
1.10
165
1053
43
164
2.80
8.32
7.4
4.8
—
—
—
0
0
115
673
1.97
8.24
1.7
1.7
36538929.52
31669976.32
pmol/l
0.04
104
581
52
221
2.54
8.15
1.4
1.2
—
—
—
0
0
301
2390
1.88
8.00
8.4
4.4
17.67
1854.82
e6/l
—
6
40
163
1077
1.83
8.00
4.2
2.8
—
—
—
0
0
209
1488
1.79
8.00
2.6
2.0
94.55
97.94
pmol/l
0.56
128
767
46
186
2.65
7.97
18.1
5.6
0.65
0.63
%
0.26
46
186
29
90
3.38
7.95
1.7
1.7
102.36
154.72
au/ml
—
9
31
12
8
15.38
7.75
2.1
1.4
—
—
—
0
0
23
62
3.86
7.73
3.8
2.5
2.46
3.14
mmol/l
0.49
18
37
174
1190
1.78
7.51
2.9
2.3
—
—
—
0
0
20
50
4.15
7.43
2.0
1.6
—
—
—
0
0
19
46
4.28
7.35
2.2
2.1
—
—
—
0
0
11
7
16.08
7.26
2.5
1.0
—
—
—
0
0
20
51
4.07
7.24
1.2
1.5
—
—
—
0
0
32
112
3.01
7.22
1.6
1.4
318.24
314.23
ug/g
0.03
17
62
21
56
3.89
7.17
2.5
1.6
1.49
1.59
mmol/l
0.22
21
56
23
68
3.52
6.79
1.4
1.2
—
—
—
0
0
30
108
2.91
6.46
19.2
7.0
—
—
—
0
0
23
71
3.37
6.37
4.9
2.5
9.10
7.48
pmol/l
0.24
23
71
23
72
3.32
6.24
1.1
1.1
—
—
—
0
0
17
32
5.49
6.22
5.2
2.2
—
—
—
0
0
255
2007
1.67
6.16
6.7
3.8
0.00
0.00
estimate
0.50
61
415
30
112
2.81
6.06
1.2
1.1
2.84
4.17
u/ml
0.28
21
71
55
273
2.16
6.05
15.3
7.3
24.29
24.05
mmol/l
0.28
55
273
256
2026
1.66
5.97
6.7
3.8
0.00
0.00
estimate
-0.00
61
420
9
6
15.28
5.92
1.0
1.2
—
—
—
0
0
85
498
1.88
5.91
1.7
1.6
1416.89
1164.39
nmol/l
1.43
68
376
256
2039
1.64
5.71
6.8
3.8
0.00
0.01
estimate
0.50
60
399
58
303
2.06
5.59
1.5
1.4
—
—
—
0
0
62
332
2.01
5.59
1.6
1.3
50.20
161.56
u/ml
4.85
20
135
222
1714
1.61
5.57
3.5
2.8
—
—
estimate
—
0
0
17
37
4.74
5.54
2.2
1.3
—
—
—
0
0
85
509
1.84
5.49
2.2
1.6
—
—
—
0
0
36
156
2.43
5.43
1.5
1.2
—
—
—
0
0
27
102
2.76
5.35
1.8
1.6
227.06
209.40
u/ml
0.10
16
60
10
11
9.28
5.31
2.3
2.6
—
—
—
0
0
39
179
2.30
5.18
1.7
1.5
—
—
—
0
0
16
45
3.66
5.09
2.3
4.3
36.20
101.58
u/ml
—
5
14
15
41
3.76
4.97
2.7
2.0
33.20
32.76
pg
0.21
15
41
18
56
3.31
4.95
1.2
1.3
—
—
—
0
0
80
487
1.79
4.88
1.5
1.2
—
—
—
0
0
340
2966
1.72
4.83
5.7
4.5
14.56
14.62
pmol/l
0.17
330
2757
8
7
11.61
4.80
1.3
2.9
163.38
161.86
ug/g
—
8
7
59
329
1.92
4.73
1.8
1.5
—
—
—
0
0
195
1500
1.55
4.71
2.6
2.0
—
—
—
0
0
13
26
5.12
4.66
1.2
1.1
—
—
—
0
0
28
116
2.51
4.66
1.1
1.1
1.99
1.41
u/ml
0.18
21
72
12
22
5.58
4.63
1.1
1.3
—
—
—
0
0
107
718
1.65
4.58
2.1
1.8
—
—
—
0
0
21
76
2.85
4.51
1.6
1.3
5019.50
11858.72
e6/l
0.98
14
50
12
23
5.34
4.49
1.9
1.0
—
—
—
0
0
162
1209
1.55
4.41
4.8
3.4
7.31
7.85
mmol/l
0.80
149
1046
102
682
1.65
4.41
2.6
2.5
2.45
2.44
mmol/l
0.16
89
615
23
89
2.67
4.38
7.8
4.2
6.57
2.09
ratio
0.86
14
49
12
24
5.11
4.35
1.1
1.1
0.07
0.19
u/ml
—
6
8
115
798
1.60
4.27
1.6
1.3
19.19
30.35
iu/ml
1.18
38
241
20
73
2.83
4.24
2.0
1.1
77.40
54.82
iu/ml
—
5
17
12
25
4.91
4.21
1.8
2.6
0.67
0.72
index
0.11
12
25
19
68
2.88
4.17
2.1
1.6
25.09
21.00
ng/l
0.55
19
68
13
30
4.44
4.16
1.1
1.2
136.69
109.73
pmol/l
0.66
13
30
26
111
2.43
4.08
1.1
1.1
0.51
0.82
u/ml
0.28
19
64
28
124
2.35
4.06
4.9
4.7
588.86
307.06
mg/l
0.42
14
62
10
18
5.66
3.99
1.2
1.2
—
—
—
0
0
29
132
2.28
3.96
1.2
1.1
1.24
4.52
u/ml
1.71
22
82
104
718
1.59
3.92
1.5
1.3
4.43
12.07
u/ml
1.67
39
281
37
191
2.03
3.71
1.6
1.5
0.32
0.34
mg/l
0.08
20
82
8
12
6.77
3.69
1.4
2.3
—
—
—
0
0
148
1121
1.49
3.62
1.5
1.5
0.76
1.76
u/ml
1.43
45
314
22
92
2.47
3.62
1.1
1.1
1.44
5.17
u/ml
1.05
14
52
31
152
2.12
3.56
1.6
1.7
26.19
8.94
u/ml
—
8
36
14
46
3.11
3.56
1.5
1.2
—
—
—
0
0
284
2447
1.48
3.54
5.5
3.6
—
0.20
—
0
5
396
3691
2.00
3.53
44.5
13.9
21.96
22.04
mg/l
0.02
355
2926
75
491
1.64
3.49
1.4
1.2
—
—
—
0
0
142
1075
1.48
3.46
5.8
3.9
22.86
8.26
mg/mmol
0.98
90
666
10
22
4.63
3.45
1.5
1.4
9166.60
25457.13
e6/l
—
5
8
12
32
3.83
3.41
1.2
1.1
0.41
0.35
u/ml
—
7
17
13
42
3.16
3.40
1.5
1.2
—
—
—
0
0
13
38
3.50
3.34
1.0
1.1
—
—
—
0
0
18
71
2.60
3.34
1.0
1.1
—
—
—
0
0
10
23
4.43
3.33
1.5
1.4
—
—
—
0
0
13
43
3.09
3.28
1.5
1.3
—
—
nmol/l
—
0
0
18
72
2.57
3.25
1.4
1.2
—
—
—
0
0
147
1132
1.46
3.25
5.4
3.2
0.00
0.01
estimate
0.99
55
339
7
11
6.45
3.19
3.6
1.3
85.71
60.45
nmol/24h
—
7
11
138
1056
1.45
3.13
4.8
3.3
73.36
49.79
mg/l
0.44
87
686
22
99
2.29
3.11
1.7
1.3
—
—
—
0
0
8
17
4.77
2.93
2.0
1.4
132.88
152.96
nmol/l
—
8
17
185
1507
1.40
2.93
6.8
3.6
0.00
0.03
estimate
1.31
52
351
50
308
1.71
2.93
7.3
3.5
—
—
—
0
0
12
38
3.22
2.87
1.2
1.1
—
—
—
0
0
51
322
1.66
2.73
4.1
4.3
9.47
42.19
ug/l
0.68
41
261
5
7
7.21
2.55
1.0
1.0
—
—
—
0
0
5
7
7.21
2.55
1.0
1.0
—
—
—
0
0
5
7
7.21
2.55
1.0
1.0
—
—
—
0
0
47
296
1.66
2.55
2.2
2.4
7.24
16.02
au/ml
—
5
27
40
241
1.73
2.55
10.2
6.4
—
—
—
0
0
49
315
1.63
2.46
1.7
1.4
23.59
24.44
iu/l
0.07
44
258
82
595
1.47
2.41
1.9
1.7
—
—
—
0
0
18
85
2.17
2.32
1.1
1.1
3.18
6.63
u/ml
—
10
44
10
34
2.99
2.29
1.0
1.0
—
—
—
0
0
6
13
4.66
2.28
1.8
1.2
—
—
—
0
0
24
128
1.93
2.26
1.3
1.2
—
—
—
0
0
5
9
5.61
2.22
1.2
1.0
—
—
—
0
0
283
2535
1.35
2.19
6.3
3.5
48.47
41.46
u/l
1.11
274
2426
9
30
3.04
2.16
1.7
1.2
—
—
—
0
0
367
3435
1.49
2.15
6.9
5.4
1.83
1.86
mu/l
0.23
357
3224
10
36
2.82
2.15
1.4
1.3
—
—
—
0
0
27
153
1.82
2.13
1.5
1.5
12.09
10.73
u/l
0.17
21
106
5
10
5.04
2.07
1.0
1.0
—
—
—
0
0
5
11
4.58
1.94
6.6
2.5
—
—
—
0
0
5
11
4.58
1.94
4.2
3.2
0.63
0.61
mmol/l
—
5
11
8
27
3.00
1.94
4.5
3.4
—
—
—
0
0
6
16
3.79
1.94
1.5
1.2
170.83
187.04
mmol/24h
—
6
16
6
16
3.79
1.94
3.5
1.3
—
—
—
0
0
41
271
1.57
1.87
1.2
1.3
—
42.80
—
0
21
6
17
3.56
1.84
1.8
1.3
—
—
—
0
0
133
1093
1.31
1.82
8.0
3.7
0.00
0.01
estimate
0.74
60
397
5
13
3.88
1.72
1.2
1.0
—
—
—
0
0
5
13
3.88
1.72
1.2
1.0
—
—
—
0
0
5
13
3.88
1.72
4.6
2.5
—
—
—
0
0
5
13
3.88
1.72
1.2
1.0
—
—
—
0
0
8
31
2.61
1.66
1.3
1.1
—
—
—
0
0
18
98
1.87
1.64
2.1
2.8
—
—
—
0
0
5
15
3.36
1.52
1.2
2.8
—
—
—
0
0
12
58
2.10
1.50
1.5
1.2
—
—
—
0
0
108
885
1.29
1.49
7.1
3.7
1.02
1.02
kg/l
0.15
72
585
7
28
2.52
1.45
1.6
1.6
—
—
—
0
0
6
22
2.75
1.44
2.7
3.7
1742.67
1172.82
mg
—
6
22
15
81
1.88
1.42
1.1
1.1
0.18
0.07
u/ml
—
9
34
40
283
1.46
1.38
1.3
1.2
—
35.75
—
0
8
6
23
2.63
1.37
1.3
2.3
—
—
—
0
0
25
160
1.60
1.35
2.0
1.9
—
—
—
0
0
9
43
2.12
1.31
2.7
9.3
6.29
6.74
mmol/l
—
9
38
9
44
2.07
1.27
5.9
3.0
—
—
—
0
0
8
36
2.24
1.25
2.0
3.2
1.36
3.92
nmol/l
—
8
36
14
78
1.82
1.22
3.5
1.9
—
—
—
0
0
24
157
1.56
1.20
2.0
2.8
—
—
—
0
0
7
30
2.35
1.13
1.1
1.6
—
—
—
0
0
15
89
1.71
1.09
1.1
1.1
—
—
—
0
0
392
3801
1.38
1.04
28.8
12.5
—
—
—
0
0
129
1123
1.21
1.04
1.6
1.6
—
—
—
0
0
9
47
1.93
1.02
1.0
1.3
—
—
—
0
0
339
3231
1.24
1.01
45.1
18.2
330.82
332.45
g/l
2.30
339
3217
342
3269
1.23
0.95
7.2
5.8
39.13
38.45
mmol/mol
0.67
331
3112
24
167
1.46
0.94
1.5
1.4
151.71
267.35
miu/ml
1.45
14
86
35
263
1.36
0.91
1.3
1.2
—
—
—
0
0
51
407
1.29
0.89
1.1
1.2
—
—
—
0
0
6
31
1.95
0.84
3.0
1.9
32.83
37.13
mg/l
—
6
23
17
113
1.53
0.83
1.8
1.4
220.59
111.49
pmol/l
0.54
17
108
8
46
1.75
0.83
1.1
1.3
—
—
—
0
0
0
26
0.00
0.78
0.0
1.2
—
—
—
0
0
33
423
0.76
0.76
1.4
1.3
—
—
—
0
0
33
421
0.77
0.74
2.5
2.9
0.58
0.75
ug/l
0.50
25
259
320
3318
0.86
0.67
4.4
4.0
1.41
1.25
mmol/l
3.26
296
3106
7
44
1.60
0.65
4.4
12.9
11.46
11.56
%
—
7
44
7
44
1.60
0.65
1.0
2.1
—
—
—
0
0
7
44
1.60
0.65
3.1
2.7
102.71
105.86
mmol/l
—
7
44
7
44
1.60
0.65
3.1
2.7
1.20
1.18
mmol/l
—
7
44
7
44
1.60
0.65
3.1
2.7
4.04
3.95
mmol/l
—
7
44
15
104
1.46
0.63
1.2
2.4
—
—
—
0
0
35
281
1.27
0.62
5.8
4.0
7.36
7.36
ph
0.01
27
199
8
50
1.61
0.61
2.3
2.6
—
13.63
—
0
6
13
88
1.49
0.61
3.8
4.2
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
920.00
—
0
5
9
136
0.65
0.52
1.2
1.1
1.69
1.58
g/l
—
9
136
340
3486
0.88
0.47
5.0
4.7
1.46
1.49
mmol/l
0.91
320
3281
27
219
1.25
0.46
2.9
2.2
1710.88
5554.55
u/l
—
8
84
10
140
0.71
0.44
1.6
1.1
0.87
0.88
g/l
—
10
140
15
113
1.34
0.43
1.6
2.2
1.27
5.16
iu/l
—
7
41
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
3.5
—
—
—
0
0
56
495
1.15
0.40
1.8
1.8
—
—
—
0
0
36
420
0.84
0.40
1.7
1.8
—
—
—
0
0
26
214
1.23
0.40
1.2
1.1
—
—
—
0
0
5
34
1.48
0.40
1.8
2.2
—
—
—
0
0
23
189
1.23
0.37
3.9
2.0
0.00
0.02
estimate
—
10
65
12
90
1.34
0.36
1.2
1.8
—
—
—
0
0
21
254
0.82
0.35
1.4
1.7
1013.99
952.68
mu/l
0.11
16
217
24
201
1.21
0.33
1.1
1.1
—
—
—
0
0
348
3536
0.91
0.27
5.8
5.4
2.76
2.77
mmol/l
0.09
326
3335
14
114
1.24
0.25
1.4
1.3
—
—
—
0
0
19
162
1.18
0.23
2.1
2.4
—
—
—
0
0
144
1499
0.94
0.22
2.7
3.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
0.45
—
0
12
0
13
0.00
0.21
0.0
3.9
—
—
—
0
0
160
1550
1.05
0.17
2.0
1.9
1.39
1.34
mmol/l
0.34
143
1340
346
3501
0.94
0.17
5.0
4.8
4.67
4.70
mmol/l
0.26
327
3311
67
708
0.94
0.16
4.4
5.1
1.53
2.27
ug/l
0.69
58
634
14
121
1.16
0.15
1.3
1.3
—
—
—
0
0
9
82
1.10
0.15
1.4
1.4
33.29
23.60
u/l
—
9
67
336
3396
0.95
0.14
5.5
4.6
5.80
5.81
mmol/l
0.02
323
3172
10
117
0.85
0.13
1.3
1.6
—
—
—
0
0
20
182
1.10
0.11
1.4
1.9
—
—
—
0
0
24
221
1.09
0.11
1.9
1.9
—
—
—
0
0
10
115
0.87
0.10
1.3
1.6
—
—
—
0
0
24
222
1.09
0.10
1.9
1.7
—
—
—
0
0
23
214
1.08
0.08
1.9
1.9
—
—
—
0
0
24
224
1.08
0.08
1.9
1.9
—
—
—
0
0
5
61
0.82
0.08
1.2
1.2
22.00
17.93
u/l
—
5
54
23
222
1.04
0.02
1.9
1.9
—
—
—
0
0
14
146
0.96
0.00
2.3
1.7
—
—
—
0
0
33
336
0.98
0.00
1.4
1.8
3.19
3.49
mmol/l
0.88
19
253
23
233
0.99
0.00
2.0
1.7
—
—
—
0
0
28
285
0.98
0.00
3.2
2.4
5.97
6.21
ph
0.69
17
192
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
19.18
—
0
6
0
6
0.00
-0.00
0.0
2.3
—
93.00
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.9
—
—
—
0
0
33
330
1.00
-0.00
3.4
2.0
0.00
0.04
estimate
0.49
12
77
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
4.52
—
0
9
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
4.40
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
11.56
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint D3_IMMUDEFOTHER and mortality.

Females

Parameter HR [95% CI] p-value
D3_IMMUDEFOTHER 1.966 [1.61, 2.4] < 0.001
Birth year 0.994 [0.99, 1.0] 0.164

During the follow-up period (1.1.1998 — 31.12.2019), 290 out of 1479 females with D3_IMMUDEFOTHER died.

Males

Parameter HR [95% CI] p-value
D3_IMMUDEFOTHER 2.078 [1.62, 2.67] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 187 out of 855 males with D3_IMMUDEFOTHER died.

Mortality risk

Mortality risk for people of age

years, who have D3_IMMUDEFOTHER.

N-year risk Females Males
1 0.147% 0.391%
5 1.014% 2.209%
10 2.58% 5.648%
15 5.512% 10.441%
20 9.694% 17.119%

Relationships between endpoints

↥

Index endpoint: D3_IMMUDEFOTHER – Other immunodeficiencies

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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