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Defects in the complement system

DOID Endpoint Browser PheWeb

D3_COMPLEMENTDEF

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

None

519870

2. Check conditions

None

519870

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D84.1
  • Hospital discharge: ICD-9 — 2798B
  • Cause of death: ICD-10 — D84.1
  • Cause of death: ICD-9 — 2798B

2 out of 7 registries used, show all original rules.

264

4. Check minimum number of events

None

264

5. Include endpoints

None

264

6. Filter based on genotype QC (FinnGen only)

250

Control definitions (FinnGen only)

Control exclude
D3_IMMUNEMECHANISM

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D84
Name in latin
Deficientia systematis complementi

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1516 980 531
Only index persons 1328 892 436
Unadjusted period prevalence (%)
Whole population 0.02 0.03 0.01
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 36.99 41.26 28.98
Only index persons 40.75 42.47 37.23

-FinnGen-

Key figures

All Female Male
Number of individuals 250 189 61
Unadjusted period prevalence (%) 0.06 0.07 0.03
Median age at first event (years) 45.41 45.39 45.45

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
264
Matched controls
2640
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D84.18
ICD-10 Finland
Other specified defect in the complement system
+∞
136.7
119
*
T78.3
ICD-10 Finland
Angioneurotic oedema
68.7
119.9
67
13
D84.1
ICD-10 Finland
Defects in the complement system
+∞
82.8
75
*
D84.19
ICD-10 Finland
Unspecified defect in the complement system
+∞
73.4
67
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
13.2
54.3
57
54
H02AB06
ATC
prednisolone; systemic
7.1
46.8
203
840
D84.11
ICD-10 Finland
Hereditary angioedema type I
+∞
40.7
38
*
338
Kela drug reimbursment
C1-esterase inhibitor, icatibant and conestat alfa
+∞
39.6
37
*
D84.13
ICD-10 Finland
Hereditary angioedema type III
+∞
39.6
37
*
R03DC03
ATC
montelukast; oral
5.4
38.0
108
302
C01CA24
ATC
epinephrine; parenteral
6.8
36.4
68
129
B06AC02
ATC
icatibant; parenteral
+∞
36.3
34
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.7
34.4
129
445
ZX120
NOMESCO Finland
Intravenous
6.4
33.9
67
134
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.5
31.2
175
798
R60.9
ICD-10 Finland
Oedema, unspecified
8.9
31.1
42
55
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
30.8
29
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.0
29.9
82
218
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
10.9
29.2
33
34
B02AA02
ATC
tranexamic acid; systemic
4.5
28.6
95
293
H02AB07
ATC
prednisone; oral
5.2
27.4
68
165
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
26.5
25
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
25.4
24
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
25.4
24
*
H02AB09
ATC
hydrocortisone; systemic
8.8
24.8
33
42
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
8.3
24.3
34
46
TDM10
NOMESCO Finland
Puncture of maxillary antrum
8.0
23.5
34
48
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
5.4
23.1
52
115
H02AB04
ATC
methylprednisolone; systemic
4.5
23.1
70
198
XQ800
NOMESCO Finland
Prick test
5.0
22.7
56
134
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
22.2
21
*
R03BB04
ATC
tiotropium bromide; inhalant
5.9
21.8
43
84
J45.9
ICD-10 Finland
Asthma, unspecified
3.7
21.5
93
337
X59
ICD-10 Finland
Exposure to unspecified factor
3.7
20.8
91
332
WW200
NOMESCO Finland
Immunization
18.0
20.7
32
20
UJF32
NOMESCO Finland
Coloscopy
3.6
20.4
96
366
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.6
20.1
91
338
R50.9
ICD-10 Finland
Fever, unspecified
3.8
20.1
80
273
T78.4
ICD-10 Finland
Allergy, unspecified
6.1
19.6
37
69
R60.0
ICD-10 Finland
Localized oedema
4.5
19.6
56
150
J01MA14
ATC
moxifloxacin; systemic
5.0
19.4
47
110
J45.0
ICD-10 Finland
Predominantly allergic asthma
4.3
18.4
56
157
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.3
18.2
40
86
R06.0
ICD-10 Finland
Dyspnoea
3.2
18.1
101
423
B06AC05
ATC
lanadelumab; parenteral
+∞
17.9
17
*
D84.12
ICD-10 Finland
Hereditary angioedema type II
+∞
17.9
17
*
P01BA02
ATC
hydroxychloroquine; oral
4.8
17.7
44
105
TPH04
NOMESCO Finland
Cathetrisation of vein
3.3
17.6
90
357
UGC12
NOMESCO Finland
Flexible bronchoscopy
6.0
17.6
33
61
J01MA12
ATC
levofloxacin; systemic
3.7
17.3
68
228
R06AE07
ATC
cetirizine; oral
3.0
17.1
163
917
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
16.8
16
*
Z01.8
ICD-10 Finland
Other specified special examinations
3.2
16.8
92
379
J45.8
ICD-10 Finland
Mixed asthma
7.9
16.8
24
33
R06AE09
ATC
levocetirizine; oral
3.4
16.4
73
265
J01FF01
ATC
clindamycin; systemic
3.0
16.0
98
429
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.0
15.9
51
148
J01MA02
ATC
ciprofloxacin; systemic
2.9
15.7
118
577
C08DA01
ATC
verapamil; systemic
7.0
15.7
25
39
WZC30
NOMESCO Finland
Teaching
3.3
15.5
73
273
R03AK06
ATC
salmeterol and fluticasone; inhalant
3.5
15.4
63
216
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.8
15.2
139
749
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.1
15.1
82
334
J31.0
ICD-10 Finland
Chronic rhinitis
4.0
15.0
49
144
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
5.9
14.8
28
52
D84.9
ICD-10 Finland
Immunodeficiency, unspecified
+∞
14.7
14
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
4.4
14.4
40
104
A02BC01
ATC
omeprazole; systemic
2.9
14.2
92
412
J45.1
ICD-10 Finland
Nonallergic asthma
4.0
14.1
44
125
ZYC01
NOMESCO Finland
Remote contact by phone
4.1
13.8
41
112
C03CA01
ATC
furosemide; systemic
3.1
13.8
73
291
UJF92
NOMESCO Finland
Capsular endoscopy
12.4
13.6
24
21
UJF30
NOMESCO Finland
Ileoscopy through colon
3.9
13.6
45
133
J47
ICD-10 Finland
Bronchiectasis
22.6
13.5
19
9
B34.9
ICD-10 Finland
Viral infection, unspecified
5.9
13.3
25
46
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
11.9
13.3
24
22
R06AX27
ATC
desloratadine; oral
2.6
13.1
122
651
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.5
12.7
33
81
B06AC01
ATC
c1-inhibitor, plasma derived; parenteral
+∞
12.6
12
*
R03AC02
ATC
salbutamol; inhalant
2.8
12.6
190
1272
N03AX16
ATC
[U] pregabalin
2.8
12.6
79
345
N06AX21
ATC
duloxetine; oral
3.2
12.4
57
208
R03AK08
ATC
formoterol and beclometasone; inhalant
5.1
12.2
27
58
SPAT1255
SPAT
Intravenous administration of medicine
5.2
12.2
26
54
Z31.5
ICD-10 Finland
Genetic counselling
3.7
11.8
42
130
A06AD11
ATC
lactulose; oral
3.6
11.6
43
137
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.6
11.5
41
127
A01AB09
ATC
miconazole; local oral
4.0
11.5
35
97
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.7
11.5
77
346
J01FA06
ATC
roxithromycin; oral
2.5
11.5
124
700
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.8
11.5
69
293
R01AD08
ATC
fluticasone; nasal
2.5
11.3
108
576
J45
ICD-10 Finland
Asthma
3.3
11.2
47
162
E0000UV, ,
ATC
2.4
11.2
139
833
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
10.8
99
515
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.3
10.8
29
73
N02AX02
ATC
tramadol; systemic, rectal
2.4
10.8
122
698
G47.3
ICD-10 Finland
Sleep apnoea
2.6
10.7
76
350
M79.7
ICD-10 Finland
Fibromyalgia
5.0
10.7
24
52
WX408
NOMESCO Finland
General anesthesy, balanced
2.5
10.6
92
466
R01AD05
ATC
budesonide; nasal
3.8
10.6
34
98
R03BA08
ATC
ciclesonide; inhalant
3.4
10.5
41
135
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
5.0
10.5
23
49
R03AK07
ATC
formoterol and budesonide; inhalant
2.6
10.4
79
376
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.2
10.2
46
165
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
4.2
10.1
28
72
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.4
10.0
176
1204
R03AC12
ATC
salmeterol; inhalant
4.9
9.7
22
48
M79.0
ICD-10 Finland
Rheumatism, unspecified
5.1
9.7
21
44
A02BC02
ATC
pantoprazole; systemic
2.4
9.7
183
1283
ZXA10
NOMESCO Finland
Bilateral
2.6
9.6
65
291
N05BA01
ATC
diazepam; systemic, rectal
3.0
9.5
47
178
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
9.5
73
348
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.3
9.5
96
518
R03DA04
ATC
theophylline; systemic, rectal
7.8
9.4
21
29
L01BA01
ATC
methotrexate; systemic
8.2
9.3
20
26
L04AX01
ATC
azathioprine; systemic
4.7
9.3
22
50
R51.80
ICD-10 Finland
Headache
2.5
9.3
72
344
R75
ICPC
Sinusitis acute/chronic
4.0
9.1
27
73
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
9.1
110
637
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
38.1
9.1
11
*
6BA02, ,
NOMESCO Finland
38.1
9.1
11
*
L50.9
ICD-10 Finland
Urticaria, unspecified
4.1
9.0
26
69
R04
ICPC
Breathing problem other
4.8
9.0
21
47
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
5.0
9.0
20
43
R01AD58
ATC
fluticasone, combinations; nasal
2.3
8.9
92
498
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.5
8.8
32
100
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.2
8.7
37
128
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.0
8.6
43
163
R53
ICD-10 Finland
Malaise and fatigue
2.3
8.6
85
450
R01AD09
ATC
mometasone; nasal
2.2
8.6
150
999
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.4
8.6
32
102
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
8.3
8.5
18
23
J32.4
ICD-10 Finland
Chronic pansinusitis
13.4
8.5
14
11
XF400
NOMESCO Finland
ECG with 12 standard connections
2.7
8.5
50
208
A07AA02
ATC
nystatin; oral
4.0
8.4
25
68
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.8
8.4
26
73
A06AC01
ATC
ispaghula (psylla seeds); oral
2.3
8.3
78
404
R03BA02
ATC
budesonide; inhalant
2.4
8.3
71
353
R03BA05
ATC
fluticasone; inhalant
2.3
8.2
75
383
C03DA01
ATC
spironolactone; oral
3.1
8.2
36
127
ZY010
NOMESCO Finland
Hospital outpatient
3.3
8.2
32
105
N03AX12
ATC
[U] gabapentin; oral
2.6
8.1
55
245
L04AB04
ATC
adalimumab; parenteral
7.6
8.1
18
25
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
3.4
8.1
30
95
C08CA13
ATC
lercanidipine; oral
2.9
8.1
42
163
Z3226
NOMESCO Finland
Physiotherapist
2.4
8.1
67
328
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.6
8.0
27
80
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.0
8.0
37
134
M54.4
ICD-10 Finland
Lumbago with sciatica
2.4
8.0
67
329
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
4.9
8.0
18
39
Z3231
NOMESCO Finland
Registered nurse
2.2
8.0
97
557
T78.2
ICD-10 Finland
Anaphylactic shock, unspecified
13.6
8.0
13
10
R01BA51
ATC
phenylpropanolamine, combinations; oral
2.8
7.9
43
171
L04AX03
ATC
methotrexate; systemic
3.0
7.9
36
130
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
7.8
48
203
J05AB11
ATC
valaciclovir; oral
2.5
7.8
58
270
4AA12, ,
NOMESCO Finland
46.4
7.8
9
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.9
7.7
38
143
J01FA10
ATC
azithromycin; systemic
2.2
7.7
185
1368
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
19.0
7.7
11
6
X57
ICD-10 Finland
Unspecified privation
7.5
7.6
17
24
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
3.0
7.6
35
127
JN3AD
NOMESCO Finland
Abdominal CT examination
2.7
7.6
43
175
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
4.6
7.6
18
41
N02AA05
ATC
oxycodone; systemic
2.6
7.5
47
201
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.8
7.4
39
152
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
7.2
7.4
17
25
R06AX26
ATC
fexofenadine; oral
3.1
7.4
32
112
D80.2
ICD-10 Finland
Selective deficiency of immunoglobulin A [IgA]
+∞
7.3
7
*
2776B
ICD-9 Finland
Other and unspecified disorders of metabolism, Other deficiencies of circulating enzymes[OEDEMA ANGIONEUROTICUM HEREDITARIUM (HANE)]
+∞
7.3
7
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.2
7.3
85
477
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
4.2
7.3
20
51
SPAT1229
SPAT
Assessment of need for aid
4.0
7.2
21
56
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
3.6
7.2
24
71
Z2446
NOMESCO Finland
Social worker
2.9
7.2
36
137
N03AE01
ATC
clonazepam; systemic
3.9
7.1
21
57
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
7.9
7.0
15
20
L50.8
ICD-10 Finland
Other urticaria
7.0
6.9
16
24
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
6.9
110
692
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.4
6.9
25
78
D07AB02
ATC
hydrocortisone butyrate; topical
2.1
6.9
90
527
ZY010, ,
SPAT
11.4
6.9
12
11
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.2
6.9
65
335
XG410
NOMESCO Finland
Flow-volume spirometry
4.5
6.9
17
40
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
6.9
31
111
FP1B5
NOMESCO Finland
Resting ECG, 12 leads
7.5
6.8
15
21
WX892
NOMESCO Finland
Monitored bed care
3.3
6.8
26
84
R42
ICD-10 Finland
Dizziness and giddiness
2.2
6.8
64
329
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
17.2
6.8
10
6
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
41.1
6.8
8
*
W84
ICD-10 Finland
Unspecified threat to breathing
41.1
6.8
8
*
WZC00
NOMESCO Finland
Treatment plan or consultation
2.0
6.8
115
738
S01GX01
ATC
cromoglicic acid; ophthalmic
2.1
6.8
75
412
R4120
NOMESCO Finland
Occupational therapy
3.0
6.7
31
112
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.0
6.7
31
112
M35.7
ICD-10 Finland
Hypermobility syndrome
8.1
6.7
14
18
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.5
6.7
47
212
N06AA09
ATC
amitriptyline; systemic
3.0
6.6
31
113
L04AB01
ATC
etanercept; parenteral
12.7
6.6
11
9
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
9.0
6.6
13
15
M25.5
ICD-10 Finland
Pain in joint
2.0
6.6
107
674
A02BC05
ATC
esomeprazole; systemic
2.0
6.6
109
692
A03FA02
ATC
cisapride; oral, rectal
3.5
6.6
23
70
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.7
6.6
39
162
WVA20, ,
SPAT
4.1
6.6
18
46
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.2
6.5
64
334
R01AD12
ATC
fluticasone furoate; nasal
2.0
6.5
107
677
M54.3
ICD-10 Finland
Sciatica
3.5
6.4
22
66
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
6.2
6.4
16
27
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.1
6.4
27
93
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.7
6.4
37
152
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.9
6.3
31
116
R07.0
ICD-10 Finland
Pain in throat
2.8
6.3
32
122
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.6
6.3
38
159
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.5
6.3
22
67
D84.8
ICD-10 Finland
Other specified immunodeficiencies
+∞
6.3
6
*
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
6.3
6
*
D84.14
ICD-10 Finland
C1 esterase inhibitor deficiency (C1-INH deficiency)
+∞
6.3
6
*
A02BC03
ATC
lansoprazole; oral
2.1
6.2
76
432
WX722
NOMESCO Finland
PEEP
4.0
6.2
18
48
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.4
6.2
23
73
R06.5
ICD-10 Finland
Mouth breathing
2.8
6.1
33
130
TLC00
NOMESCO Finland
Insertion of intrauterine device
2.8
6.1
32
124
A08
ICPC
Swelling
3.6
6.1
20
58
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
6.1
113
740
J01DA08
ATC
[U] cefaclor
2.6
6.1
37
155
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
7.0
6.1
14
21
ZXH09, ,
SPAT
5.8
6.1
16
29
H02BX01
ATC
methylprednisolone, combinations; systemic
5.8
6.1
16
29
Z2221
NOMESCO Finland
Medical doctor
2.0
6.0
88
532

TimeCodeWAS

↥

TODO / Current known limitations:

  • Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
  • Legend / how to read the glyphs.
  • Proper column names.
  • Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
  • Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
  • Download CSV not working.
  • No filters and sorters.
  • Limited amount of endpoints with TimeCodeWAS data.
  • Cross-links to Risteys lab test pages for lab test codes.
OMOP Concept
ln(OR) -5y
ln(OR) -1y
ln(OR) -1m
ln(OR) d0
ln(OR) +1m
ln(OR) +1y
ln(OR) +5y
MCC -5y
MCC -1y
MCC -1m
MCC d0
MCC +1m
MCC +1y
MCC +5y
Nonfamilial hypogammaglobulinaemia
D80.1 (45533001)
Selective deficiency of immunoglobulin G [IgG] subclasses
D80.3 (45595778)
Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma
4477-6 (3003245)
Complement C1 esterase inhibitor.functional/Complement C1 esterase inhibitor.total in Serum or Plasma
10634-4 (3023659)
Hereditary angioedema type I
D84.11 (2000501383)
Hereditary angioedema type III
D84.13 (2000501385)
Other specified defect in the complement system
D84.18 (2000501387)
Unspecified defect in the complement system
D84.19 (2000501388)
Immunodeficiency with predominantly antibody defects, unspecified
D80.9 (45533002)
Angioneurotic oedema
T78.3 (45551447)
Defects in the complement system
D84.1 (45581336)
C1-esterase inhibitor, icatibant and conestat alfa
338 (2001600299)
Body height measure
50373000 (4177340)
Body mass index
60621009 (4245997)
SMOKING - SMOKE2: no - SMOKE3: never - SMOKE5: Unspecified
SMOKING-2-3-0 (2002330113)
immunoglobulins, normal human, for extravascular adm.
J06BA01 (21601256)
immunoglobulins, normal human, for intravascular adm.
J06BA02 (21601257)
Complement C3 [Mass/volume] in Serum or Plasma
4485-9 (3000620)
Complement C4 [Mass/volume] in Serum or Plasma
4498-2 (3017766)
icatibant; parenteral
B06AC02 (40253604)
Complement alternate pathway AH50 actual/normal in Serum by Immunoassay
74520-8 (44817194)
Other immunodeficiencies with predominantly antibody defects
D80.8 (45561935)
Thorax X-ray examination
GD1AA (2001303617)
epinephrine; parenteral
C01CA24 (21600303)
tranexamic acid; oral, parenteral
B02AA02 (21601036)
epinephrine
S01EA01 (21603673)
paracetamol; oral, parenteral, rectal
N02BE01 (21604344)
IgG [Mass/volume] in Serum or Plasma
2465-3 (3005719)
IgG subclass 3 [Mass/volume] in Serum
2468-7 (3024139)
IgG subclass 1 [Mass/volume] in Serum
2466-1 (3027135)
IgM [Mass/volume] in Serum or Plasma
2472-9 (3028026)
IgG subclass 2 [Mass/volume] in Serum
2467-9 (3028192)
Clinical & Laboratory Dermatological Immunology Physician
207NI0002X (38003841)
Pulmonary Disease
29 (38004472)
Emergency Medicine
93 (38004510)
Immunoglobulin typing, IgG
1712009 (4062490)
Predominantly allergic asthma
J45.0 (45557624)
Asthma, unspecified
J45.9 (45562456)
Chronic maxillary sinusitis
J32.0 (45586667)
Pediatric Gastroenterology
OMOP4822029 (45756810)
Pharmacy visit
OMOP4822462 (581458)
Outpatient Visit
OP (9202)
prednisolone
A07EA01 (21600653)
prednisolone; oral, parenteral
H02AB06 (21602734)
Infectious Disease
44 (38004484)
montelukast; oral
R03DC03 (21603356)
CBC W Ordered Manual Differential panel - Blood
57782-5 (40760892)
Rheumatology
66 (38004491)
Internal Medicine
11 (38004456)
Medical doctor
Z2221 (2001311556)
salmeterol and fluticasone
R03AK06 (21603280)
Basophils [#/volume] in Blood
26444-0 (3006315)
Intravenous
ZX120 (2001311495)
Monocytes [#/volume] in Blood
26484-6 (3001604)
Lymphocytes [#/volume] in Blood
26474-7 (3019198)
Eosinophils [#/volume] in Blood
26449-9 (3013115)
Otolaryngology
4 (38004449)
IgE [Units/volume] in Serum or Plasma
19113-0 (3005322)
Upper gastrointestinal surgery
106 (44777669)
IgA [Mass/volume] in Serum or Plasma
2458-8 (3007164)
Eosinophils/Leukocytes in Blood
26450-7 (3006504)
Monocytes/Leukocytes in Blood
26485-3 (3019069)
Basophils/Leukocytes in Blood
30180-4 (3022096)
Forced vital capacity [Volume] Respiratory system --post bronchodilation
19875-4 (3001668)
FEV1 --post bronchodilation
20155-8 (3023550)
FEV1/FVC --post bronchodilation
69970-2 (42868459)
FVC percent change Respiratory system
69982-7 (42868471)
FEV1 percent change
69983-5 (42868472)
Lymphocytes/Leukocytes in Blood
26478-8 (3002030)
tiotropium bromide; inhalant
R03BB04 (21603296)
Office Visit
OMOP4822458 (581477)
Differential panel, method unspecified - Blood
69738-3 (42870588)
Albumin [Presence] in Urine by Test strip
50949-7 (3029937)
desloratadine; oral
R06AX27 (21603526)
FEV1/FVC
19926-5 (3011505)
Forced vital capacity [Volume] Respiratory system
19870-5 (3020158)
FEV1
20150-9 (3024653)
Neutrophils [#/volume] in Blood by Automated count
751-8 (3013650)
Neutrophils/Leukocytes in Blood
26511-6 (3018010)
doxycycline; oral, parenteral
J01AA02 (21602800)
cetirizine; oral
R06AE07 (21603497)
pregabalin; oral
N02BF02 (955152)
Emergency Room Visit
ER (9203)
Inpatient Hospital
21 (8717)
Urinalysis microscopic panel [#/volume] - Urine by Automated count
50554-5 (3029287)
Leukocyte esterase [Presence] in Urine by Automated test strip
60026-2 (40763086)
Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method
4537-7 (3013707)
Normoblasts [#/volume] in Blood
715-3 (3021589)
fluconazole; oral, parenteral
J02AC01 (21603080)
Short blood count panel - Blood
55429-5 (40758558)
Outpatient Hospital
22 (8756)
budesonide; inhalant
R03BA02 (21603285)
levofloxacin; inhalant, oral, parenteral
J01MA12 (21603019)
Ketones [Presence] in Urine by Test strip
2514-8 (3035350)
Nitrite [Presence] in Urine by Test strip
5802-4 (3021601)
Bilirubin.total [Moles/volume] in Serum or Plasma
14631-6 (3006140)
Glucose [Presence] in Urine by Test strip
25428-4 (3009261)
Nuclear Ab [Titer] in Serum
29953-7 (3037522)
Fever, unspecified
R50.9 (45582716)
Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
6768-6 (3035995)
Teaching
WZC30 (2001310891)
Platelets [#/volume] in Blood
26515-7 (3007461)
Exposure to unspecified factor
X59 (45756412)
Hemoglobin [Mass/volume] in Blood
718-7 (3000963)
MCH [Entitic mass]
28539-5 (3035941)
MCV [Entitic mean volume] in Red Blood Cells
30428-7 (3024731)
Erythrocytes [#/volume] in Blood
26453-1 (3026361)
Epithelial cells [#/volume] in Urine
30383-4 (3000850)
Hematocrit [Volume Fraction] of Blood by calculation
20570-8 (3009542)
C reactive protein [Mass/volume] in Serum or Plasma
1988-5 (3020460)
Supplier / Service Provider
OMOP5117446 (33004)
hydrocortisone; oral, parenteral
H02AB09 (21602737)
Leukocytes [#/volume] in Blood
26464-8 (3010813)
furosemide; oral, parenteral
C03CA01 (21601518)
roxithromycin; oral
J01FA06 (21602974)
Coloscopy
UJF32 (2001305029)
Calcium.ionized [Moles/volume] in Serum or Plasma
1995-0 (3021347)
Esophagoscopy, gastroscopy and duodenoscopy
UJD10 (2001304788)
methylprednisolone; oral, parenteral
H02AB04 (21602732)
Psychiatry
26 (38004469)
salbutamol; inhalant
R03AC02 (21603256)
Pneumonia, unspecified
J18.9 (45601123)
Laboratory Visit
OMOP4822461 (32036)
Albumin [Mass/volume] in Serum or Plasma
1751-7 (3024561)
Cathetrisation of vein
TPH04 (2001309597)
Spirometry for bronchospasm with prolonged evaluation after bronchodilator
113016006 (4010399)
calcium (different salts in combination); oral
A12AA20 (21600872)
Physiotherapist
Z3226 (2001311560)
Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction
14804-9 (3022250)
Asthma
J45 (45596282)
General anesthesia, balanced
WX408 (2001310808)
Bacteria identified in Blood by Culture
600-7 (3023368)
Gastroenterology
10 (38004455)
Casts [#/volume] in Urine by Automated count
51483-6 (3030467)
Dyspnoea
R06.0 (45558449)
Paranasal sinuses X-ray examination in one projection
DM1QA (2001301761)
Scheduled procedure
ZXD10 (2001311387)
Abdominal ultrasound examination
JN3AE (2001305555)
Case Management Agency
251B00000X (38004193)
Bacteria [Presence] in Urine
87829-8 (36304419)
Erythrocytes [#/volume] in Urine
30391-7 (3002582)
ciprofloxacin; oral, parenteral
J01MA02 (21603009)
metoclopramide; oral, parenteral, rectal
A03FA01 (21600484)
Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
2157-6 (3007220)
amoxicillin; oral, parenteral
J01CA04 (21602823)
cefalexin; oral
J01DB01 (21602870)
One hour or less
ZXE00 (2001311394)
omeprazole; oral, parenteral
A02BC01 (21600096)
Physical Medicine And Rehabilitation
25 (38004468)
More than one and less than three hours
ZXE10 (2001311401)
Magnesium [Moles/volume] in Serum or Plasma
2601-3 (3012095)
Potassium [Moles/volume] in Serum or Plasma
2823-3 (3023103)
Creatinine [Moles/volume] in Serum or Plasma
14682-9 (3020564)
Sodium [Moles/volume] in Serum or Plasma
2951-2 (3019550)
fluticasone; inhalant
R03BA05 (21603288)
amoxicillin and beta-lactamase inhibitor; oral, parenteral
J01CR02 (21602863)
combinations of corticosteroids
D07AB30 (21602118)
combinations of corticosteroids
D07XB30 (21602188)
Acute maxillary sinusitis
J01.0 (45601112)
pH of Serum or Plasma
2753-2 (3018418)
Prealbumin [Mass/volume] in Serum or Plasma
14338-8 (3013742)
Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
30248-9 (3015399)
Puncture of maxillary antrum
TDM10 (2001301819)
Acute bronchitis, unspecified
J20.9 (45562445)

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
118
96
21.42
128.90
2.5
1.5
0.19
0.23
g/l
3.49
100
96
61
26
30.21
87.51
2.8
1.3
—
—
—
0
0
58
25
29.45
82.71
2.7
1.4
0.31
0.39
g/l
0.61
50
20
58
25
29.45
82.71
2.7
1.4
2.68
2.89
g/l
0.17
50
19
58
25
29.45
82.71
2.7
1.4
5.12
6.92
g/l
1.92
50
20
65
50
16.92
70.84
2.6
2.4
0.69
0.75
g/l
0.07
55
45
171
814
4.12
27.60
13.9
7.0
—
—
—
0
0
218
1273
5.09
25.45
16.6
7.0
0.57
0.54
e9/l
1.12
212
1084
218
1274
5.08
25.40
16.7
7.0
0.04
0.04
e9/l
0.73
212
1079
103
369
3.94
24.72
2.1
1.4
512.73
551.81
titre
0.09
22
83
218
1295
4.92
24.29
16.8
7.0
2.13
2.05
e9/l
0.37
212
1137
29
8
40.47
23.53
3.1
1.3
740.41
1385.25
u/ml
—
29
8
218
1315
4.78
23.27
17.1
7.3
0.19
0.19
e9/l
0.22
213
1144
42
81
5.98
21.59
1.4
1.2
—
—
—
0
0
50
115
5.13
21.18
2.2
1.7
7.10
4.68
iu/ml
0.27
16
22
139
670
3.27
20.07
3.1
1.5
1.79
2.08
g/l
1.57
118
393
27
35
8.48
19.92
4.5
2.8
4.15
4.86
e9/l
0.66
27
35
197
1179
3.64
19.57
15.8
6.9
55.19
55.33
%
0.06
197
1140
219
1406
4.27
19.46
18.6
10.2
3.97
3.85
e9/l
0.43
213
1211
192
1145
3.48
18.88
20.5
10.9
0.00
0.00
e9/l
0.70
166
912
124
583
3.13
18.28
10.4
5.0
—
—
—
0
0
112
510
3.08
17.27
7.4
3.8
—
—
—
0
0
164
984
2.76
14.23
17.2
8.6
1.20
1.22
mmol/l
1.78
157
919
58
201
3.42
13.83
5.9
5.9
0.86
0.79
%
0.08
21
64
30
64
5.16
13.67
4.2
2.4
59.78
60.42
%
0.10
30
64
56
193
3.41
13.45
5.9
5.6
0.39
0.65
%
0.57
18
55
67
259
3.13
13.32
3.3
1.6
—
—
—
0
0
172
1088
2.67
12.92
12.8
8.4
1.21
1.22
mmol/l
0.68
153
964
41
119
3.89
12.68
4.7
2.3
—
—
—
0
0
54
190
3.32
12.50
6.2
6.1
0.00
0.10
%
1.24
17
52
55
196
3.28
12.47
6.2
6.3
0.00
0.08
%
0.49
17
49
117
625
2.57
12.41
7.4
4.3
7.41
7.39
ph
1.82
77
406
168
1067
2.58
12.25
4.0
2.8
76.43
74.80
nmol/l
0.34
158
979
112
589
2.57
12.24
5.3
2.5
2.79
2.78
mg/l
0.03
104
514
74
317
2.85
12.15
3.1
2.0
—
—
—
0
0
90
430
2.66
11.93
4.5
2.7
496.40
530.06
mosm/kgh2o
0.84
85
374
152
929
2.50
11.93
9.4
5.3
36.80
36.85
g/l
0.04
146
882
23
25
9.97
11.76
5.3
1.4
—
—
—
0
0
130
747
2.46
11.58
10.7
6.8
—
—
—
0
0
188
1291
2.58
11.13
11.9
5.5
6.38
6.44
mmol/l
0.17
182
1209
227
1720
3.28
10.97
16.8
7.5
77.63
82.53
u/l
1.06
221
1626
176
1187
2.45
10.60
8.5
6.4
11.40
11.92
umol/l
0.14
167
1126
115
646
2.38
10.54
5.5
3.3
0.67
0.32
e6/l
0.28
95
446
32
90
3.91
10.29
1.2
1.2
—
—
—
0
0
113
646
2.31
9.78
3.6
2.0
117.07
156.01
u/l
1.21
108
622
125
751
2.26
9.55
5.8
3.4
88.84
53.80
e6/l
0.21
105
550
27
72
4.06
9.32
20.6
6.3
—
—
—
0
0
19
40
5.04
8.73
3.3
2.6
—
—
—
0
0
138
890
2.15
8.56
7.0
4.2
121.88
67.35
e6/l
0.23
110
578
96
538
2.23
8.48
3.3
2.2
0.99
1.23
mg/l
0.44
84
416
20
32
6.67
8.19
1.8
1.7
—
—
—
0
0
113
684
2.14
8.16
3.7
2.5
51.98
65.27
u/l
1.21
108
638
19
44
4.58
7.82
1.2
1.3
3.00
3.52
u/ml
—
9
25
21
54
4.14
7.59
2.8
2.6
4.79
1.49
index
0.52
14
31
46
199
2.59
7.16
5.4
6.8
5.15
5.08
kpa
0.22
46
191
74
396
2.21
7.16
5.1
2.7
121.63
80.15
ug/g
0.55
64
318
55
260
2.41
7.10
1.6
1.4
—
—
—
0
0
17
39
4.59
7.07
3.4
2.6
9.56
9.21
kpa
0.30
17
39
17
39
4.59
7.07
3.5
2.6
4.79
4.93
kpa
0.34
17
39
99
597
2.05
7.00
1.8
1.6
22.10
20.71
nmol/l
0.40
87
517
50
228
2.47
6.97
20.4
11.2
—
—
—
0
0
57
279
2.33
6.79
16.5
7.4
7.38
7.38
ph
0.19
31
167
33
126
2.85
6.52
23.8
7.0
0.69
0.61
%
0.86
33
126
42
183
2.54
6.43
3.1
3.6
82.02
72.39
e9/l
0.81
28
132
33
127
2.83
6.42
23.8
7.0
1.46
1.26
%
0.42
33
127
144
1012
1.93
6.39
5.9
3.3
6.12
6.21
ph
0.38
75
543
129
876
1.92
6.33
15.1
9.5
1.14
1.14
inr
0.04
108
709
70
384
2.12
6.28
1.9
1.6
60317947.98
55090268.72
pmol/l
0.03
63
334
57
288
2.25
6.27
1.7
1.7
1509.68
1167.73
nmol/l
1.57
45
225
17
32
5.60
6.27
1.2
1.3
—
—
—
0
0
114
746
1.93
6.23
5.7
3.3
15.36
29.81
ng/l
1.92
77
429
54
269
2.27
6.14
4.3
4.3
4.45
6.82
umol/l
1.07
44
239
47
221
2.37
6.10
13.9
13.9
24.37
24.59
mmol/l
0.22
47
221
45
209
2.39
6.00
1.7
1.3
47.33
161.68
u/ml
3.51
13
88
58
301
2.19
5.97
3.1
1.4
—
—
—
0
0
53
267
2.23
5.86
17.5
7.6
1.62
1.44
mmol/l
0.14
48
222
45
212
2.35
5.81
10.2
9.0
1.62
0.83
mmol/l
0.72
39
171
68
381
2.06
5.72
4.0
3.5
2.17
2.96
e6/l
0.47
41
185
19
56
3.58
5.70
3.6
2.9
7.42
7.42
ph
0.15
19
56
52
264
2.21
5.63
2.3
1.5
—
—
—
0
0
164
1237
1.86
5.52
5.0
3.3
89.40
84.16
ug/l
0.23
159
1173
15
29
5.42
5.48
1.5
1.6
—
—
—
0
0
15
29
5.42
5.48
1.5
1.6
—
—
—
0
0
15
29
5.42
5.48
1.5
1.6
—
—
—
0
0
15
29
5.42
5.48
1.5
1.6
—
—
—
0
0
45
218
2.28
5.44
10.8
8.9
7.42
7.42
ph
0.20
20
122
16
34
4.94
5.40
2.1
1.8
1.62
1.45
mmol/l
0.30
16
34
53
276
2.15
5.38
22.8
8.9
103.40
104.52
mmol/l
0.66
53
276
9
9
10.30
5.06
1.6
1.6
11.30
10.56
umol/l
—
9
9
33
145
2.46
4.95
1.3
1.2
—
—
—
0
0
112
775
1.77
4.82
3.5
3.1
2.33
2.36
mmol/l
2.45
104
723
39
191
2.22
4.58
13.3
10.7
9.70
7.04
mmol/l
1.09
39
184
22
82
2.84
4.54
1.2
1.1
3.87
5.01
u/ml
0.16
15
52
105
723
1.75
4.53
2.7
2.5
—
—
—
0
0
97
653
1.77
4.53
4.4
2.7
—
—
—
0
0
24
94
2.71
4.53
1.6
1.1
—
—
—
0
0
83
536
1.80
4.45
2.2
2.1
—
—
—
0
0
22
84
2.77
4.35
1.1
1.1
1.98
0.78
u/ml
0.34
15
55
124
911
1.68
4.13
2.5
2.0
98.55
96.53
pmol/l
0.20
74
459
15
47
3.32
4.12
7.9
4.6
6.12
1.95
ratio
—
10
21
24
99
2.57
4.10
10.5
4.6
—
—
—
0
0
8
10
8.21
4.09
2.1
3.4
0.50
0.60
index
—
8
10
22
87
2.67
4.08
1.5
1.6
34.33
9.84
u/ml
—
6
20
36
180
2.16
4.02
7.3
3.4
—
—
—
0
0
79
517
1.75
3.99
1.7
1.3
19.22
24.75
iu/ml
0.40
29
155
10
19
5.43
3.86
1.1
1.3
119.50
101.42
pmol/l
—
10
19
63
390
1.81
3.83
3.7
3.5
33.94
458.94
ng/l
3.42
33
263
160
1275
1.65
3.75
7.0
3.6
0.00
0.00
estimate
-0.00
42
256
19
73
2.73
3.73
1.8
1.4
364.11
305.69
ug/g
—
9
38
20
79
2.66
3.73
1.1
1.1
0.63
0.71
u/ml
0.05
14
45
10
20
5.15
3.72
1.1
1.2
0.07
0.12
u/ml
—
5
7
159
1267
1.64
3.71
7.0
3.5
0.00
0.00
estimate
0.50
42
252
14
40
3.64
3.67
4.1
2.8
5.32
8.42
pmol/l
0.73
14
40
18
68
2.77
3.64
1.2
1.1
1.25
6.19
u/ml
—
10
39
12
30
4.14
3.64
2.3
2.1
—
—
—
0
0
10
21
4.91
3.59
1.0
1.2
—
—
—
0
0
7
9
7.95
3.58
2.1
1.8
140.14
139.56
nmol/l
—
7
9
160
1284
1.62
3.57
7.1
3.6
0.00
0.01
estimate
0.50
42
240
72
473
1.72
3.55
1.5
1.3
5.97
11.26
u/ml
0.70
27
191
6
6
10.19
3.51
1.3
2.8
197.17
168.83
ug/g
—
6
6
22
95
2.44
3.44
1.2
1.2
0.35
4.19
u/ml
1.93
16
59
12
32
3.88
3.43
1.5
1.2
—
—
nmol/l
—
0
0
9
18
5.14
3.40
2.9
1.7
—
—
—
0
0
10
23
4.48
3.34
1.2
1.3
—
—
—
0
0
94
672
1.62
3.32
8.0
3.5
0.00
0.00
estimate
0.50
42
243
50
302
1.81
3.27
1.4
1.2
—
—
—
0
0
123
941
1.58
3.26
6.8
3.3
0.00
0.02
estimate
0.88
35
217
17
67
2.64
3.19
1.2
1.2
—
—
—
0
0
17
67
2.64
3.19
1.2
1.2
—
—
—
0
0
13
44
3.06
3.18
2.5
1.7
24.07
18.77
ng/l
0.54
13
44
135
1060
1.56
3.16
3.2
2.8
—
—
estimate
—
0
0
10
25
4.12
3.12
1.3
1.2
—
—
—
0
0
35
191
1.96
3.11
21.4
8.9
24.37
23.84
mmol/l
0.59
35
191
16
62
2.68
3.10
1.4
1.8
113.53
148.06
au/ml
—
6
22
13
41
3.28
3.10
1.3
1.2
—
—
—
0
0
101
745
1.58
3.09
1.6
1.5
0.46
1.54
u/ml
2.51
32
205
25
122
2.16
2.98
1.8
1.6
—
—
—
0
0
12
37
3.35
2.97
1.0
1.1
—
—
—
0
0
96
706
1.57
2.96
5.1
3.0
0.00
0.01
estimate
0.74
39
213
16
64
2.60
2.93
1.1
1.1
3.77
7.70
u/ml
—
8
34
63
419
1.66
2.92
1.9
2.3
2.44
2.44
mmol/l
0.17
55
377
6
9
6.79
2.88
2.5
2.9
—
—
—
0
0
61
404
1.66
2.87
1.8
1.7
—
—
—
0
0
7
14
5.10
2.74
1.0
1.4
—
—
—
0
0
10
29
3.54
2.72
1.2
1.1
0.51
0.37
u/ml
—
5
16
6
10
6.11
2.71
3.8
1.3
95.50
64.40
nmol/24h
—
6
10
8
19
4.31
2.70
1.8
1.4
—
—
—
0
0
13
49
2.74
2.66
1.3
1.1
—
—
—
0
0
6
11
5.55
2.55
2.3
2.0
4.27
4.91
mg/l
—
6
11
21
102
2.15
2.55
1.3
1.5
9.93
10.74
u/l
0.10
15
70
23
116
2.08
2.54
19.3
6.6
25.59
24.57
mmol/l
0.57
23
109
17
77
2.29
2.43
1.8
1.3
—
—
—
0
0
212
1901
1.58
2.31
6.0
4.6
14.46
14.54
pmol/l
0.17
205
1771
10
34
3.02
2.30
1.7
1.2
—
—
—
0
0
8
23
3.55
2.29
1.0
1.0
—
—
—
0
0
5
9
5.64
2.22
4.2
3.2
0.63
0.61
mmol/l
—
5
9
15
67
2.31
2.22
1.9
1.7
174.90
239.00
u/ml
—
10
39
13
56
2.39
2.08
1.2
1.1
0.14
0.07
u/ml
—
7
24
9
32
2.87
2.02
1.8
1.2
—
—
—
0
0
31
189
1.73
1.98
1.5
1.4
—
—
—
0
0
10
39
2.62
1.96
1.0
1.1
—
—
—
0
0
248
2340
1.99
1.95
40.8
13.2
21.35
21.49
mg/l
0.03
221
1824
5
11
4.61
1.95
1.2
1.0
—
—
—
0
0
5
11
4.61
1.95
1.2
1.0
—
—
—
0
0
6
16
3.81
1.94
5.2
4.4
—
—
—
0
0
6
16
3.81
1.94
1.0
1.1
—
—
—
0
0
9
34
2.70
1.88
1.7
1.3
—
—
—
0
0
5
12
4.22
1.83
1.4
1.2
—
—
—
0
0
96
765
1.40
1.83
5.2
3.3
7.78
8.09
mmol/l
0.25
89
659
30
186
1.69
1.82
1.3
1.2
—
15.00
—
0
5
26
156
1.74
1.77
7.6
7.7
—
—
—
0
0
45
312
1.53
1.75
1.2
1.2
—
—
—
0
0
22
126
1.81
1.74
1.8
1.3
0.16
0.32
mg/l
1.40
14
56
5
13
3.90
1.72
1.4
2.1
—
—
—
0
0
5
13
3.90
1.72
1.0
1.2
—
—
—
0
0
113
938
1.36
1.64
2.3
2.0
—
—
—
0
0
5
15
3.38
1.53
1.4
1.4
—
—
—
0
0
16
87
1.89
1.49
1.3
1.1
—
—
—
0
0
5
17
2.98
1.36
1.6
1.5
—
—
—
0
0
5
17
2.98
1.36
1.0
1.1
—
—
—
0
0
70
555
1.36
1.33
7.4
3.4
1.02
1.02
kg/l
0.33
41
357
178
1616
1.31
1.25
6.1
3.6
44.44
39.94
u/l
0.47
171
1550
80
654
1.32
1.24
6.1
3.9
6.67
8.48
mg/mmol
0.23
49
397
18
109
1.70
1.22
2.0
1.8
—
—
—
0
0
5
19
2.66
1.22
1.0
1.2
—
—
—
0
0
231
2188
1.45
1.18
6.9
5.5
1.73
1.87
mu/l
1.17
225
2062
5
20
2.53
1.15
1.2
1.1
—
—
—
0
0
195
2082
0.76
1.15
4.3
4.0
1.39
1.26
mmol/l
1.98
184
1956
56
443
1.34
1.08
2.0
1.8
—
—
—
0
0
9
46
1.99
1.04
1.0
1.1
—
—
—
0
0
78
651
1.28
1.02
5.1
3.3
27.40
50.36
mg/l
1.12
48
416
17
107
1.63
1.02
13.8
11.2
15.41
15.88
%
0.39
17
102
42
321
1.37
1.01
2.1
1.7
—
—
—
0
0
5
23
2.20
0.98
1.0
1.1
—
—
—
0
0
11
63
1.78
0.91
53.3
10.7
61.65
65.23
%
0.18
11
63
23
163
1.45
0.85
1.3
1.2
—
—
—
0
0
251
2439
1.59
0.85
39.8
15.9
72.67
69.57
umol/l
0.62
251
2411
203
2133
0.79
0.83
5.1
4.5
5.79
5.77
mmol/l
0.10
196
2001
23
165
1.43
0.81
4.7
4.4
7.35
7.36
ph
0.07
17
116
10
58
1.75
0.81
58.6
10.8
68.30
63.38
%
—
10
58
0
25
0.00
0.79
0.0
1.4
—
—
—
0
0
0
25
0.00
0.79
0.0
11.6
—
0.69
—
0
25
0
27
0.00
0.78
0.0
16.6
—
878.30
—
0
27
5
26
1.94
0.71
1.6
2.5
4.00
3.97
mmol/l
—
5
26
5
26
1.94
0.71
1.6
2.5
1.20
1.18
mmol/l
—
5
26
5
26
1.94
0.71
1.6
2.5
103.40
105.85
mmol/l
—
5
26
5
26
1.94
0.71
1.8
2.2
33.20
32.65
pg
—
5
26
5
26
1.94
0.71
2.6
2.6
1.12
3.41
nmol/l
—
5
26
13
85
1.56
0.70
7.2
5.4
244.20
305.11
mg/l
—
5
44
13
191
0.66
0.69
3.1
2.1
6.06
6.20
ph
—
8
127
213
2213
0.81
0.66
5.7
5.4
2.79
2.80
mmol/l
0.06
204
2092
26
199
1.34
0.65
1.7
1.5
—
—
—
0
0
19
138
1.41
0.64
3.6
2.3
1005.50
5815.40
u/l
—
6
51
24
183
1.34
0.62
1.2
1.3
—
26.04
—
0
11
8
51
1.59
0.61
3.6
4.2
—
—
—
0
0
16
114
1.43
0.60
3.9
2.0
0.00
0.02
estimate
—
8
41
211
2187
0.82
0.57
4.9
4.7
1.47
1.50
mmol/l
0.39
202
2063
5
90
0.55
0.56
1.2
1.1
1.78
1.59
g/l
—
5
90
6
38
1.59
0.54
1.0
1.3
—
—
—
0
0
11
74
1.51
0.54
1.2
1.7
—
—
—
0
0
7
49
1.44
0.46
1.6
1.9
—
—
—
0
0
246
2412
1.29
0.43
24.9
11.5
—
—
—
0
0
6
94
0.63
0.43
1.8
1.2
0.80
0.87
g/l
—
6
94
25
204
1.25
0.42
3.3
3.9
17.51
8.16
ug/l
0.27
18
158
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
5.2
—
2.24
—
0
17
18
222
0.80
0.36
1.3
1.7
3.14
3.44
mmol/l
—
10
164
214
2195
0.87
0.36
4.9
4.8
4.72
4.74
mmol/l
0.11
204
2080
10
73
1.38
0.35
1.7
1.8
1.11
5.68
iu/l
—
5
31
209
2036
1.13
0.30
7.0
5.7
39.39
38.34
mmol/mol
0.81
203
1941
77
713
1.11
0.30
1.5
1.6
—
—
—
0
0
32
282
1.15
0.27
1.0
1.2
—
—
—
0
0
5
73
0.68
0.26
1.2
1.5
—
—
—
0
0
34
302
1.14
0.26
1.7
1.9
—
—
—
0
0
5
75
0.66
0.26
1.2
1.6
—
—
—
0
0
13
157
0.82
0.23
2.1
1.7
—
—
—
0
0
10
79
1.28
0.22
1.3
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
217.98
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
93
972
0.93
0.18
2.5
3.0
—
—
—
0
0
7
58
1.21
0.18
1.3
2.0
—
—
—
0
0
7
59
1.19
0.18
1.7
2.7
—
—
—
0
0
12
101
1.20
0.17
2.2
2.2
—
—
—
0
0
17
149
1.15
0.16
2.2
1.5
—
—
—
0
0
9
81
1.11
0.15
1.1
1.3
—
—
—
0
0
17
150
1.14
0.15
2.2
1.5
—
—
—
0
0
17
150
1.14
0.15
2.2
1.5
—
—
—
0
0
16
143
1.13
0.12
2.3
1.5
—
—
—
0
0
10
114
0.87
0.09
2.6
3.0
1.02
1.02
ratio
—
10
106
6
55
1.09
0.09
2.0
2.9
2.08
4.99
u/ml
—
6
55
256
2562
0.97
0.07
49.7
20.9
133.82
134.74
g/l
0.56
256
2543
103
1010
1.03
0.06
1.9
1.9
1.38
1.36
mmol/l
0.07
90
881
32
335
0.95
0.06
4.1
5.0
2.12
1.66
ug/l
0.24
25
300
16
148
1.09
0.06
2.3
1.5
—
—
—
0
0
14
150
0.93
0.04
1.1
1.1
—
—
—
0
0
15
143
1.05
0.01
1.2
1.1
—
—
—
0
0
21
211
0.99
0.00
3.3
1.9
0.00
0.07
estimate
—
9
45
208
2081
1.00
0.00
42.8
17.2
331.63
332.46
g/l
0.61
208
2076
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
101.80
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
10.97
—
0
6
8
85
0.94
-0.00
2.5
1.7
—
—
—
0
0
256
2560
1.00
-0.00
48.8
20.6
29.86
30.06
pg
0.96
256
2543
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.42
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
256
2560
1.00
-0.00
50.4
21.3
40.33
40.33
%
0.00
256
2542
256
2559
1.01
-0.00
48.9
20.7
89.95
90.16
fl
0.28
256
2542
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
4.66
—
0
6

Mortality – FinRegistry

↥

Association

Association between endpoint D3_COMPLEMENTDEF and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_COMPLEMENTDEF.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: D3_COMPLEMENTDEF – Defects in the complement system

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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