No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
279 |
4. Check minimum number of eventsNone |
279 |
5. Include endpointsNone |
279 |
6. Filter based on genotype QC (FinnGen only) |
250 |
Control definitions (FinnGen only)
- Control exclude
- D3_IMMUNEMECHANISM
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D84
- Name in latin
- Deficientia systematis complementi
Similar endpoints
↥List of similar endpoints to
Defects in the complement system
based on the number of shared cases.
Similar with more cases:
- Other immunodeficiencies
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1516 | 980 | 531 |
| Only index persons | 1328 | 892 | 436 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.01 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 36.99 | 41.26 | 28.98 |
| Only index persons | 40.75 | 42.47 | 37.23 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 250 | 189 | 61 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.03 |
| Median age at first event (years) | 45.41 | 45.39 | 45.45 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 264
- Matched controls
- 2640
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D84.18
ICD-10 Finland
Other specified defect in the complement system
+∞
136.7
119
*
T78.3
ICD-10 Finland
Angioneurotic oedema
68.7
119.9
67
13
D84.1
ICD-10 Finland
Defects in the complement system
+∞
82.8
75
*
D84.19
ICD-10 Finland
Unspecified defect in the complement system
+∞
73.4
67
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
13.2
54.3
57
54
H02AB06
ATC
prednisolone; systemic
7.1
46.8
203
840
D84.11
ICD-10 Finland
Hereditary angioedema type I
+∞
40.7
38
*
D84.13
ICD-10 Finland
Hereditary angioedema type III
+∞
39.6
37
*
338
Kela drug reimbursment
C1-esterase inhibitor, icatibant and conestat alfa
+∞
39.6
37
*
R03DC03
ATC
montelukast; oral
5.4
38.0
108
302
C01CA24
ATC
epinephrine; parenteral
6.8
36.4
68
129
B06AC02
ATC
icatibant; parenteral
+∞
36.3
34
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.7
34.4
129
445
ZX120
NOMESCO Finland
Intravenous
6.4
33.9
67
134
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.5
31.2
175
798
R60.9
ICD-10 Finland
Oedema, unspecified
8.9
31.1
42
55
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
30.8
29
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.0
29.9
82
218
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
10.9
29.2
33
34
B02AA02
ATC
tranexamic acid; systemic
4.5
28.6
95
293
H02AB07
ATC
prednisone; oral
5.2
27.4
68
165
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
26.5
25
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
25.4
24
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
25.4
24
*
H02AB09
ATC
hydrocortisone; systemic
8.8
24.8
33
42
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
8.3
24.3
34
46
TDM10
NOMESCO Finland
Puncture of maxillary antrum
8.0
23.5
34
48
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
5.4
23.1
52
115
H02AB04
ATC
methylprednisolone; systemic
4.5
23.1
70
198
XQ800
NOMESCO Finland
Prick test
5.0
22.7
56
134
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
22.2
21
*
R03BB04
ATC
tiotropium bromide; inhalant
5.9
21.8
43
84
J45.9
ICD-10 Finland
Asthma, unspecified
3.7
21.5
93
337
X59
ICD-10 Finland
Exposure to unspecified factor
3.7
20.8
91
332
WW200
NOMESCO Finland
Immunization
18.0
20.7
32
20
UJF32
NOMESCO Finland
Coloscopy
3.6
20.4
96
366
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.6
20.1
91
338
R50.9
ICD-10 Finland
Fever, unspecified
3.8
20.1
80
273
T78.4
ICD-10 Finland
Allergy, unspecified
6.1
19.6
37
69
R60.0
ICD-10 Finland
Localized oedema
4.5
19.6
56
150
J01MA14
ATC
moxifloxacin; systemic
5.0
19.4
47
110
J45.0
ICD-10 Finland
Predominantly allergic asthma
4.3
18.4
56
157
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.3
18.2
40
86
R06.0
ICD-10 Finland
Dyspnoea
3.2
18.1
101
423
D84.12
ICD-10 Finland
Hereditary angioedema type II
+∞
17.9
17
*
B06AC05
ATC
lanadelumab; parenteral
+∞
17.9
17
*
P01BA02
ATC
hydroxychloroquine; oral
4.8
17.7
44
105
TPH04
NOMESCO Finland
Cathetrisation of vein
3.3
17.6
90
357
UGC12
NOMESCO Finland
Flexible bronchoscopy
6.0
17.6
33
61
J01MA12
ATC
levofloxacin; systemic
3.7
17.3
68
228
R06AE07
ATC
cetirizine; oral
3.0
17.1
163
917
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
16.8
16
*
Z01.8
ICD-10 Finland
Other specified special examinations
3.2
16.8
92
379
J45.8
ICD-10 Finland
Mixed asthma
7.9
16.8
24
33
R06AE09
ATC
levocetirizine; oral
3.4
16.4
73
265
J01FF01
ATC
clindamycin; systemic
3.0
16.0
98
429
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.0
15.9
51
148
J01MA02
ATC
ciprofloxacin; systemic
2.9
15.7
118
577
C08DA01
ATC
verapamil; systemic
7.0
15.7
25
39
WZC30
NOMESCO Finland
Teaching
3.3
15.5
73
273
R03AK06
ATC
salmeterol and fluticasone; inhalant
3.5
15.4
63
216
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.8
15.2
139
749
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.1
15.1
82
334
J31.0
ICD-10 Finland
Chronic rhinitis
4.0
15.0
49
144
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
5.9
14.8
28
52
D84.9
ICD-10 Finland
Immunodeficiency, unspecified
+∞
14.7
14
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
4.4
14.4
40
104
A02BC01
ATC
omeprazole; systemic
2.9
14.2
92
412
J45.1
ICD-10 Finland
Nonallergic asthma
4.0
14.1
44
125
ZYC01
NOMESCO Finland
Remote contact by phone
4.1
13.8
41
112
C03CA01
ATC
furosemide; systemic
3.1
13.8
73
291
UJF92
NOMESCO Finland
Capsular endoscopy
12.4
13.6
24
21
UJF30
NOMESCO Finland
Ileoscopy through colon
3.9
13.6
45
133
J47
ICD-10 Finland
Bronchiectasis
22.6
13.5
19
9
B34.9
ICD-10 Finland
Viral infection, unspecified
5.9
13.3
25
46
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
11.9
13.3
24
22
R06AX27
ATC
desloratadine; oral
2.6
13.1
122
651
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.5
12.7
33
81
B06AC01
ATC
c1-inhibitor, plasma derived; parenteral
+∞
12.6
12
*
R03AC02
ATC
salbutamol; inhalant
2.8
12.6
190
1272
N03AX16
ATC
[U] pregabalin
2.8
12.6
79
345
N06AX21
ATC
duloxetine; oral
3.2
12.4
57
208
R03AK08
ATC
formoterol and beclometasone; inhalant
5.1
12.2
27
58
SPAT1255
SPAT
Intravenous administration of medicine
5.2
12.2
26
54
Z31.5
ICD-10 Finland
Genetic counselling
3.7
11.8
42
130
A06AD11
ATC
lactulose; oral
3.6
11.6
43
137
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.6
11.5
41
127
A01AB09
ATC
miconazole; local oral
4.0
11.5
35
97
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.7
11.5
77
346
J01FA06
ATC
roxithromycin; oral
2.5
11.5
124
700
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.8
11.5
69
293
R01AD08
ATC
fluticasone; nasal
2.5
11.3
108
576
J45
ICD-10 Finland
Asthma
3.3
11.2
47
162
E0000UV, ,
ATC
2.4
11.2
139
833
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
10.8
99
515
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.3
10.8
29
73
N02AX02
ATC
tramadol; systemic, rectal
2.4
10.8
122
698
G47.3
ICD-10 Finland
Sleep apnoea
2.6
10.7
76
350
M79.7
ICD-10 Finland
Fibromyalgia
5.0
10.7
24
52
WX408
NOMESCO Finland
General anesthesy, balanced
2.5
10.6
92
466
R01AD05
ATC
budesonide; nasal
3.8
10.6
34
98
R03BA08
ATC
ciclesonide; inhalant
3.4
10.5
41
135
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
5.0
10.5
23
49
R03AK07
ATC
formoterol and budesonide; inhalant
2.6
10.4
79
376
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.2
10.2
46
165
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
4.2
10.1
28
72
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.4
10.0
176
1204
R03AC12
ATC
salmeterol; inhalant
4.9
9.7
22
48
M79.0
ICD-10 Finland
Rheumatism, unspecified
5.1
9.7
21
44
A02BC02
ATC
pantoprazole; systemic
2.4
9.7
183
1283
ZXA10
NOMESCO Finland
Bilateral
2.6
9.6
65
291
N05BA01
ATC
diazepam; systemic, rectal
3.0
9.5
47
178
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
9.5
73
348
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.3
9.5
96
518
R03DA04
ATC
theophylline; systemic, rectal
7.8
9.4
21
29
L01BA01
ATC
methotrexate; systemic
8.2
9.3
20
26
L04AX01
ATC
azathioprine; systemic
4.7
9.3
22
50
R51.80
ICD-10 Finland
Headache
2.5
9.3
72
344
R75
ICPC
Sinusitis acute/chronic
4.0
9.1
27
73
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
9.1
110
637
6BA02, ,
NOMESCO Finland
38.1
9.1
11
*
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
38.1
9.1
11
*
L50.9
ICD-10 Finland
Urticaria, unspecified
4.1
9.0
26
69
R04
ICPC
Breathing problem other
4.8
9.0
21
47
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
5.0
9.0
20
43
R01AD58
ATC
fluticasone, combinations; nasal
2.3
8.9
92
498
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.5
8.8
32
100
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.2
8.7
37
128
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.0
8.6
43
163
R53
ICD-10 Finland
Malaise and fatigue
2.3
8.6
85
450
R01AD09
ATC
mometasone; nasal
2.2
8.6
150
999
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.4
8.6
32
102
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
8.3
8.5
18
23
J32.4
ICD-10 Finland
Chronic pansinusitis
13.4
8.5
14
11
XF400
NOMESCO Finland
ECG with 12 standard connections
2.7
8.5
50
208
A07AA02
ATC
nystatin; oral
4.0
8.4
25
68
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.8
8.4
26
73
A06AC01
ATC
ispaghula (psylla seeds); oral
2.3
8.3
78
404
R03BA02
ATC
budesonide; inhalant
2.4
8.3
71
353
R03BA05
ATC
fluticasone; inhalant
2.3
8.2
75
383
C03DA01
ATC
spironolactone; oral
3.1
8.2
36
127
ZY010
NOMESCO Finland
Hospital outpatient
3.3
8.2
32
105
N03AX12
ATC
[U] gabapentin; oral
2.6
8.1
55
245
L04AB04
ATC
adalimumab; parenteral
7.6
8.1
18
25
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
3.4
8.1
30
95
C08CA13
ATC
lercanidipine; oral
2.9
8.1
42
163
Z3226
NOMESCO Finland
Physiotherapist
2.4
8.1
67
328
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.6
8.0
27
80
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.0
8.0
37
134
M54.4
ICD-10 Finland
Lumbago with sciatica
2.4
8.0
67
329
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
4.9
8.0
18
39
Z3231
NOMESCO Finland
Registered nurse
2.2
8.0
97
557
T78.2
ICD-10 Finland
Anaphylactic shock, unspecified
13.6
8.0
13
10
R01BA51
ATC
phenylpropanolamine, combinations; oral
2.8
7.9
43
171
L04AX03
ATC
methotrexate; systemic
3.0
7.9
36
130
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
7.8
48
203
J05AB11
ATC
valaciclovir; oral
2.5
7.8
58
270
4AA12, ,
NOMESCO Finland
46.4
7.8
9
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.9
7.7
38
143
J01FA10
ATC
azithromycin; systemic
2.2
7.7
185
1368
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
19.0
7.7
11
6
X57
ICD-10 Finland
Unspecified privation
7.5
7.6
17
24
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
3.0
7.6
35
127
JN3AD
NOMESCO Finland
Abdominal CT examination
2.7
7.6
43
175
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
4.6
7.6
18
41
N02AA05
ATC
oxycodone; systemic
2.6
7.5
47
201
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.8
7.4
39
152
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
7.2
7.4
17
25
R06AX26
ATC
fexofenadine; oral
3.1
7.4
32
112
2776B
ICD-9 Finland
Other and unspecified disorders of metabolism, Other deficiencies of circulating enzymes[OEDEMA ANGIONEUROTICUM HEREDITARIUM (HANE)]
+∞
7.3
7
*
D80.2
ICD-10 Finland
Selective deficiency of immunoglobulin A [IgA]
+∞
7.3
7
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.2
7.3
85
477
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
4.2
7.3
20
51
SPAT1229
SPAT
Assessment of need for aid
4.0
7.2
21
56
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
3.6
7.2
24
71
Z2446
NOMESCO Finland
Social worker
2.9
7.2
36
137
N03AE01
ATC
clonazepam; systemic
3.9
7.1
21
57
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
7.9
7.0
15
20
L50.8
ICD-10 Finland
Other urticaria
7.0
6.9
16
24
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
6.9
110
692
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.4
6.9
25
78
D07AB02
ATC
hydrocortisone butyrate; topical
2.1
6.9
90
527
ZY010, ,
SPAT
11.4
6.9
12
11
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.2
6.9
65
335
XG410
NOMESCO Finland
Flow-volume spirometry
4.5
6.9
17
40
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
6.9
31
111
FP1B5
NOMESCO Finland
Resting ECG, 12 leads
7.5
6.8
15
21
WX892
NOMESCO Finland
Monitored bed care
3.3
6.8
26
84
R42
ICD-10 Finland
Dizziness and giddiness
2.2
6.8
64
329
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
17.2
6.8
10
6
W84
ICD-10 Finland
Unspecified threat to breathing
41.1
6.8
8
*
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
41.1
6.8
8
*
WZC00
NOMESCO Finland
Treatment plan or consultation
2.0
6.8
115
738
S01GX01
ATC
cromoglicic acid; ophthalmic
2.1
6.8
75
412
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.0
6.7
31
112
R4120
NOMESCO Finland
Occupational therapy
3.0
6.7
31
112
M35.7
ICD-10 Finland
Hypermobility syndrome
8.1
6.7
14
18
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.5
6.7
47
212
N06AA09
ATC
amitriptyline; systemic
3.0
6.6
31
113
L04AB01
ATC
etanercept; parenteral
12.7
6.6
11
9
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
9.0
6.6
13
15
M25.5
ICD-10 Finland
Pain in joint
2.0
6.6
107
674
A02BC05
ATC
esomeprazole; systemic
2.0
6.6
109
692
A03FA02
ATC
cisapride; oral, rectal
3.5
6.6
23
70
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.7
6.6
39
162
WVA20, ,
SPAT
4.1
6.6
18
46
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.2
6.5
64
334
R01AD12
ATC
fluticasone furoate; nasal
2.0
6.5
107
677
M54.3
ICD-10 Finland
Sciatica
3.5
6.4
22
66
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
6.2
6.4
16
27
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.1
6.4
27
93
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.7
6.4
37
152
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.9
6.3
31
116
R07.0
ICD-10 Finland
Pain in throat
2.8
6.3
32
122
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.6
6.3
38
159
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.5
6.3
22
67
D84.14
ICD-10 Finland
C1 esterase inhibitor deficiency (C1-INH deficiency)
+∞
6.3
6
*
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
6.3
6
*
D84.8
ICD-10 Finland
Other specified immunodeficiencies
+∞
6.3
6
*
A02BC03
ATC
lansoprazole; oral
2.1
6.2
76
432
WX722
NOMESCO Finland
PEEP
4.0
6.2
18
48
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.4
6.2
23
73
R06.5
ICD-10 Finland
Mouth breathing
2.8
6.1
33
130
TLC00
NOMESCO Finland
Insertion of intrauterine device
2.8
6.1
32
124
A08
ICPC
Swelling
3.6
6.1
20
58
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
6.1
113
740
J01DA08
ATC
[U] cefaclor
2.6
6.1
37
155
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
7.0
6.1
14
21
H02BX01
ATC
methylprednisolone, combinations; systemic
5.8
6.1
16
29
ZXH09, ,
SPAT
5.8
6.1
16
29
Z2221
NOMESCO Finland
Medical doctor
2.0
6.0
88
532
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
118
96
21.42
128.90
2.5
1.5
0.19
0.23
g/l
3.49
100
96
47
18
31.55
69.47
2.6
1.2
—
—
—
0
0
29
8
40.47
23.53
3.1
1.3
740.41
1385.25
u/ml
—
29
8
50
115
5.13
21.18
2.2
1.7
7.10
4.68
iu/ml
0.27
16
22
139
670
3.27
20.07
3.1
1.5
1.79
2.08
g/l
1.57
118
393
219
1406
4.27
19.46
18.6
10.2
3.97
3.85
e9/l
0.43
213
1211
34
59
6.47
19.37
1.8
1.6
—
—
—
0
0
31
55
6.25
17.24
2.3
1.6
—
—
—
0
0
69
236
3.60
17.04
2.6
1.6
—
—
—
0
0
25
36
7.57
16.84
1.7
1.8
—
—
—
0
0
81
313
3.29
16.43
3.6
1.8
—
—
—
0
0
27
47
6.29
15.26
2.9
2.2
—
—
—
0
0
65
229
3.44
15.20
2.8
1.7
—
—
—
0
0
164
984
2.76
14.23
17.2
8.6
1.20
1.22
mmol/l
1.78
157
919
46
142
3.71
13.04
2.7
1.6
—
—
—
0
0
172
1088
2.67
12.92
12.8
8.4
1.21
1.22
mmol/l
0.68
153
964
168
1067
2.58
12.25
4.0
2.8
76.43
74.80
nmol/l
0.34
158
979
112
589
2.57
12.24
5.3
2.5
2.79
2.78
mg/l
0.03
104
514
26
54
5.23
12.18
1.6
1.5
—
—
—
0
0
152
929
2.50
11.93
9.4
5.3
36.80
36.85
g/l
0.04
146
882
22
41
5.76
11.56
1.6
1.5
—
—
—
0
0
188
1291
2.58
11.13
11.9
5.5
6.38
6.44
mmol/l
0.17
182
1209
22
43
5.49
10.99
1.6
1.6
—
—
—
0
0
227
1720
3.28
10.97
16.8
7.5
77.63
82.53
u/l
1.06
221
1626
23
47
5.27
10.95
1.3
1.3
—
—
—
0
0
23
47
5.27
10.95
1.3
1.3
—
—
—
0
0
176
1187
2.45
10.60
8.5
6.4
11.40
11.92
umol/l
0.14
167
1126
115
646
2.38
10.54
5.5
3.3
0.67
0.32
e6/l
0.28
95
446
15
8
19.78
10.38
1.7
1.1
11.40
11.75
u/l
—
15
8
48
179
3.06
9.98
2.1
1.5
—
—
—
0
0
113
646
2.31
9.78
3.6
2.0
117.07
156.01
u/l
1.21
108
622
20
40
5.33
9.73
1.1
1.1
—
—
—
0
0
227
1768
3.03
9.48
12.3
4.3
11.88
9.91
mm/h
1.51
220
1664
20
42
5.07
9.22
1.1
1.3
1.56
1.40
u/ml
—
9
20
96
524
2.31
9.15
3.8
3.4
455.97
801.53
ng/l
1.79
83
432
32
101
3.47
8.69
2.4
1.3
—
—
—
0
0
17
19
9.48
8.67
3.0
2.1
—
—
—
0
0
17
19
9.48
8.67
3.0
2.1
—
—
—
0
0
17
19
9.48
8.67
3.0
2.1
—
—
—
0
0
29
86
3.66
8.63
1.9
1.3
1.98
2.91
u/ml
—
5
16
96
538
2.23
8.48
3.3
2.2
0.99
1.23
mg/l
0.44
84
416
16
17
9.94
8.40
5.8
3.7
—
—
—
0
0
113
684
2.14
8.16
3.7
2.5
51.98
65.27
u/l
1.21
108
638
32
106
3.30
8.05
2.2
1.8
—
—
—
0
0
25
71
3.78
7.91
2.0
1.3
7.59
82.83
u/ml
—
7
9
19
44
4.58
7.82
1.2
1.3
3.00
3.52
u/ml
—
9
25
21
54
4.14
7.59
2.8
2.6
4.79
1.49
index
0.52
14
31
44
181
2.72
7.58
5.1
7.2
1.17
1.16
mmol/l
0.01
34
135
17
25
7.19
7.42
1.2
1.7
—
—
—
0
0
46
199
2.59
7.16
5.4
6.8
5.15
5.08
kpa
0.22
46
191
17
39
4.59
7.07
3.5
2.6
4.79
4.93
kpa
0.34
17
39
99
597
2.05
7.00
1.8
1.6
22.10
20.71
nmol/l
0.40
87
517
44
194
2.52
6.57
4.2
3.0
—
—
—
0
0
33
126
2.85
6.52
23.8
7.0
0.69
0.61
%
0.86
33
126
15
23
6.84
6.43
2.4
2.1
—
—
—
0
0
33
127
2.83
6.42
23.8
7.0
1.46
1.26
%
0.42
33
127
16
27
6.24
6.41
1.6
1.6
—
—
—
0
0
70
384
2.12
6.28
1.9
1.6
60317947.98
55090268.72
pmol/l
0.03
63
334
57
288
2.25
6.27
1.7
1.7
1509.68
1167.73
nmol/l
1.57
45
225
114
746
1.93
6.23
5.7
3.3
15.36
29.81
ng/l
1.92
77
429
16
39
4.30
6.18
1.6
1.1
—
—
—
0
0
54
269
2.27
6.14
4.3
4.3
4.45
6.82
umol/l
1.07
44
239
72
403
2.08
6.11
4.0
3.3
0.82
0.80
e6/l
0.04
45
203
47
221
2.37
6.10
13.9
13.9
24.37
24.59
mmol/l
0.22
47
221
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
17
44
4.06
6.09
2.6
8.8
0.33
0.40
iu/ml
0.25
12
24
45
209
2.39
6.00
1.7
1.3
47.33
161.68
u/ml
3.51
13
88
53
267
2.23
5.86
17.5
7.6
1.62
1.44
mmol/l
0.14
48
222
45
212
2.35
5.81
10.2
9.0
1.62
0.83
mmol/l
0.72
39
171
16
41
4.09
5.80
1.3
1.2
—
—
—
0
0
68
381
2.06
5.72
4.0
3.5
2.17
2.96
e6/l
0.47
41
185
164
1237
1.86
5.52
5.0
3.3
89.40
84.16
ug/l
0.23
159
1173
16
34
4.94
5.40
2.1
1.8
1.62
1.45
mmol/l
0.30
16
34
53
276
2.15
5.38
22.8
8.9
103.40
104.52
mmol/l
0.66
53
276
38
173
2.40
5.28
4.1
2.8
63.59
69.66
ml/min/173m2
0.60
22
73
15
31
5.06
5.21
2.4
1.9
—
—
—
0
0
9
9
10.30
5.06
1.6
1.6
11.30
10.56
umol/l
—
9
9
14
28
5.22
5.02
1.4
1.5
—
—
—
0
0
18
56
3.38
4.99
1.4
1.4
—
—
—
0
0
26
101
2.75
4.97
1.4
1.3
—
—
—
0
0
20
68
3.10
4.83
1.7
1.5
0.01
0.07
iu/ml
—
8
12
112
775
1.77
4.82
3.5
3.1
2.33
2.36
mmol/l
2.45
104
723
15
43
3.64
4.68
1.3
1.1
—
—
—
0
0
39
191
2.22
4.58
13.3
10.7
9.70
7.04
mmol/l
1.09
39
184
22
84
2.77
4.35
1.1
1.1
1.98
0.78
u/ml
0.34
15
55
82
533
1.78
4.28
2.7
2.5
—
—
—
0
0
124
911
1.68
4.13
2.5
2.0
98.55
96.53
pmol/l
0.20
74
459
15
47
3.32
4.12
7.9
4.6
6.12
1.95
ratio
—
10
21
8
10
8.21
4.09
2.1
3.4
0.50
0.60
index
—
8
10
22
87
2.67
4.08
1.5
1.6
34.33
9.84
u/ml
—
6
20
11
22
5.17
4.05
1.5
1.1
—
—
—
0
0
79
517
1.75
3.99
1.7
1.3
19.22
24.75
iu/ml
0.40
29
155
95
655
1.70
3.98
2.1
1.8
—
—
—
0
0
25
107
2.48
3.97
3.1
1.6
—
—
—
0
0
10
19
5.43
3.86
1.1
1.3
119.50
101.42
pmol/l
—
10
19
63
390
1.81
3.83
3.7
3.5
33.94
458.94
ng/l
3.42
33
263
43
235
1.99
3.80
1.7
2.1
—
—
—
0
0
160
1275
1.65
3.75
7.0
3.6
0.00
0.00
estimate
-0.00
42
256
19
73
2.73
3.73
1.8
1.4
364.11
305.69
ug/g
—
9
38
159
1267
1.64
3.71
7.0
3.5
0.00
0.00
estimate
0.50
42
252
14
40
3.64
3.67
4.1
2.8
5.32
8.42
pmol/l
0.73
14
40
7
9
7.95
3.58
3.1
2.2
—
—
—
0
0
7
9
7.95
3.58
3.1
2.2
—
—
—
0
0
7
9
7.95
3.58
3.1
2.2
—
—
—
0
0
160
1284
1.62
3.57
7.1
3.6
0.00
0.01
estimate
0.50
42
240
36
189
2.05
3.55
1.6
2.0
—
—
—
0
0
72
473
1.72
3.55
1.5
1.3
5.97
11.26
u/ml
0.70
27
191
12
31
4.00
3.54
1.5
1.4
—
—
—
0
0
8
13
6.31
3.52
1.3
1.4
—
—
—
0
0
10
22
4.68
3.46
2.6
1.0
—
—
—
0
0
22
95
2.44
3.44
1.2
1.2
0.35
4.19
u/ml
1.93
16
59
7
10
7.15
3.38
1.6
1.1
—
—
—
0
0
7
10
7.15
3.38
1.6
1.1
—
—
—
0
0
10
23
4.48
3.34
2.6
1.1
—
—
—
0
0
94
672
1.62
3.32
8.0
3.5
0.00
0.00
estimate
0.50
42
243
123
941
1.58
3.26
6.8
3.3
0.00
0.02
estimate
0.88
35
217
135
1060
1.56
3.16
3.2
2.8
—
—
estimate
—
0
0
35
191
1.96
3.11
21.4
8.9
24.37
23.84
mmol/l
0.59
35
191
16
62
2.68
3.10
1.4
1.8
113.53
148.06
au/ml
—
6
22
101
745
1.58
3.09
1.6
1.5
0.46
1.54
u/ml
2.51
32
205
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
8
16
5.12
3.07
1.6
2.4
143.75
140.06
%
—
8
16
5
5
10.16
2.99
3.4
3.0
—
—
—
0
0
5
5
10.16
2.99
1.2
1.2
—
—
—
0
0
96
706
1.57
2.96
5.1
3.0
0.00
0.01
estimate
0.74
39
213
8
17
4.82
2.94
2.0
1.5
—
—
—
0
0
63
419
1.66
2.92
1.9
2.3
2.44
2.44
mmol/l
0.17
55
377
10
27
3.81
2.91
2.9
5.6
105.60
109.30
%
—
10
27
7
13
5.50
2.89
5.4
1.9
—
—
—
0
0
7
13
5.50
2.89
5.4
1.9
—
—
—
0
0
7
13
5.50
2.89
5.4
1.9
—
—
—
0
0
7
13
5.50
2.89
5.4
1.9
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
7
13
5.50
2.89
1.0
1.1
114.71
120.69
%
—
7
13
12
39
3.17
2.81
1.6
1.2
—
—
—
0
0
11
36
3.14
2.59
2.8
1.6
—
—
—
0
0
6
11
5.55
2.55
2.3
2.0
4.27
4.91
mg/l
—
6
11
21
102
2.15
2.55
1.3
1.5
9.93
10.74
u/l
0.10
15
70
23
116
2.08
2.54
19.3
6.6
25.59
24.57
mmol/l
0.57
23
109
13
52
2.58
2.40
1.2
2.2
—
—
—
0
0
5
8
6.34
2.38
1.0
1.4
179.20
209.50
u/l
—
5
8
199
1756
1.54
2.37
4.9
3.5
—
—
—
0
0
9
28
3.29
2.33
1.3
1.2
—
—
—
0
0
212
1901
1.58
2.31
6.0
4.6
14.46
14.54
pmol/l
0.17
205
1771
5
9
5.64
2.22
4.2
3.2
0.63
0.61
mmol/l
—
5
9
15
67
2.31
2.22
1.9
1.7
174.90
239.00
u/ml
—
10
39
6
14
4.36
2.16
1.8
1.1
—
—
—
0
0
10
36
2.85
2.16
1.7
1.2
—
—
—
0
0
9
31
2.97
2.09
1.8
1.2
—
—
—
0
0
13
56
2.39
2.08
1.2
1.1
0.14
0.07
u/ml
—
7
24
5
10
5.07
2.08
1.6
1.4
—
—
—
0
0
9
32
2.87
2.02
1.2
1.3
—
—
—
0
0
248
2340
1.99
1.95
40.8
13.2
21.35
21.49
mg/l
0.03
221
1824
9
33
2.79
1.95
1.8
1.2
—
—
—
0
0
9
33
2.79
1.95
1.8
1.2
—
—
—
0
0
9
33
2.79
1.95
1.8
1.2
—
—
—
0
0
5
11
4.61
1.95
1.0
1.4
—
—
—
0
0
5
11
4.61
1.95
1.6
1.5
—
—
—
0
0
5
11
4.61
1.95
1.2
1.0
—
—
—
0
0
6
16
3.81
1.94
1.0
1.3
—
—
—
0
0
7
22
3.24
1.89
1.4
1.7
—
—
—
0
0
12
53
2.32
1.83
1.1
1.1
—
2.28
—
0
11
5
12
4.22
1.83
1.6
1.5
—
—
—
0
0
15
74
2.09
1.79
1.8
1.6
—
—
—
0
0
6
18
3.39
1.75
1.0
1.1
—
—
—
0
0
22
126
1.81
1.74
1.8
1.3
0.16
0.32
mg/l
1.40
14
56
5
13
3.90
1.72
1.0
1.2
—
—
—
0
0
13
63
2.12
1.62
5.6
1.9
—
—
—
0
0
5
14
3.62
1.62
1.8
2.4
—
—
—
0
0
16
85
1.94
1.58
1.3
1.1
—
—
—
0
0
16
85
1.94
1.58
1.3
1.1
—
—
—
0
0
13
64
2.08
1.57
1.5
1.3
—
—
—
0
0
5
15
3.38
1.53
1.4
1.2
—
—
—
0
0
13
66
2.02
1.46
2.1
1.4
—
—
—
0
0
5
16
3.16
1.44
1.0
1.6
—
—
—
0
0
6
22
2.77
1.44
1.2
1.1
—
—
—
0
0
6
23
2.64
1.37
1.0
1.0
—
—
—
0
0
224
2096
1.45
1.37
29.0
12.4
88.23
87.73
ml/min/173m2
0.13
214
1921
13
68
1.96
1.36
6.9
2.0
—
—
—
0
0
70
555
1.36
1.33
7.4
3.4
1.02
1.02
kg/l
0.33
41
357
178
1616
1.31
1.25
6.1
3.6
44.44
39.94
u/l
0.47
171
1550
80
654
1.32
1.24
6.1
3.9
6.67
8.48
mg/mmol
0.23
49
397
8
38
2.14
1.19
1.5
1.5
—
—
—
0
0
6
26
2.34
1.19
1.5
1.2
—
—
—
0
0
231
2188
1.45
1.18
6.9
5.5
1.73
1.87
mu/l
1.17
225
2062
195
2082
0.76
1.15
4.3
4.0
1.39
1.26
mmol/l
1.98
184
1956
16
96
1.71
1.13
1.6
1.6
—
—
—
0
0
19
288
0.63
1.11
1.5
1.9
2.96
3.38
ratio
0.94
12
229
17
107
1.63
1.02
13.8
11.2
15.41
15.88
%
0.39
17
102
9
49
1.87
0.99
1.2
1.2
—
—
—
0
0
25
174
1.48
0.99
1.0
1.0
—
—
—
0
0
6
28
2.17
0.92
1.3
1.1
—
72.20
—
0
5
6
28
2.17
0.92
3.3
1.6
—
—
—
0
0
6
28
2.17
0.92
3.3
1.6
—
—
—
0
0
14
87
1.64
0.89
1.9
1.4
—
—
—
0
0
251
2439
1.59
0.85
39.8
15.9
72.67
69.57
umol/l
0.62
251
2411
6
31
1.96
0.85
1.0
1.5
6.52
7.13
mmol/l
—
6
26
203
2133
0.79
0.83
5.1
4.5
5.79
5.77
mmol/l
0.10
196
2001
6
109
0.54
0.74
1.3
1.4
—
—
—
0
0
5
25
2.02
0.73
1.0
1.0
—
—
—
0
0
5
26
1.94
0.71
2.6
2.6
1.12
3.41
nmol/l
—
5
26
5
26
1.94
0.71
1.6
2.5
103.40
105.85
mmol/l
—
5
26
5
26
1.94
0.71
1.6
2.5
1.20
1.18
mmol/l
—
5
26
5
28
1.80
0.66
3.2
1.6
—
—
—
0
0
213
2213
0.81
0.66
5.7
5.4
2.79
2.80
mmol/l
0.06
204
2092
19
138
1.41
0.64
3.6
2.3
1005.50
5815.40
u/l
—
6
51
5
29
1.74
0.64
3.2
1.6
—
—
—
0
0
5
29
1.74
0.64
3.2
1.6
—
—
—
0
0
24
183
1.34
0.62
1.2
1.3
—
26.04
—
0
11
8
53
1.53
0.59
1.4
1.4
31.33
22.09
u/l
—
8
43
211
2187
0.82
0.57
4.9
4.7
1.47
1.50
mmol/l
0.39
202
2063
5
90
0.55
0.56
1.2
1.1
1.78
1.59
g/l
—
5
90
9
64
1.42
0.52
1.3
1.8
—
—
—
0
0
7
48
1.47
0.47
1.6
1.5
—
—
—
0
0
6
94
0.63
0.43
1.8
1.2
0.80
0.87
g/l
—
6
94
25
204
1.25
0.42
3.3
3.9
17.51
8.16
ug/l
0.27
18
158
17
213
0.78
0.38
8.6
5.2
—
—
—
0
0
20
162
1.25
0.37
1.4
1.3
—
—
—
0
0
18
222
0.80
0.36
1.3
1.7
3.14
3.44
mmol/l
—
10
164
214
2195
0.87
0.36
4.9
4.8
4.72
4.74
mmol/l
0.11
204
2080
10
73
1.38
0.35
1.7
1.8
1.11
5.68
iu/l
—
5
31
209
2036
1.13
0.30
7.0
5.7
39.39
38.34
mmol/mol
0.81
203
1941
9
75
1.21
0.25
1.6
1.7
—
—
—
0
0
6
81
0.73
0.24
1.3
1.6
—
1.22
—
0
50
6
81
0.73
0.24
1.3
1.6
—
0.97
—
0
50
6
81
0.73
0.24
1.3
1.6
—
1.16
—
0
50
0
11
0.00
0.21
0.0
1.0
—
217.98
—
0
11
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
6
48
1.26
0.20
2.0
1.2
—
—
—
0
0
24
270
0.88
0.20
2.9
4.2
21.04
21.78
%
—
9
122
6
52
1.16
0.19
1.7
1.5
—
—
—
0
0
5
67
0.74
0.17
1.4
1.4
—
—
—
0
0
6
55
1.09
0.09
2.0
2.9
2.08
4.99
u/ml
—
6
55
50
480
1.05
0.08
1.6
1.5
—
—
—
0
0
256
2562
0.97
0.07
49.7
20.9
133.82
134.74
g/l
0.56
256
2543
103
1010
1.03
0.06
1.9
1.9
1.38
1.36
mmol/l
0.07
90
881
32
335
0.95
0.06
4.1
5.0
2.12
1.66
ug/l
0.24
25
300
40
411
0.97
0.03
2.7
2.2
—
—
—
0
0
10
99
1.01
0.00
2.6
1.7
—
—
—
0
0
208
2081
1.00
0.00
42.8
17.2
331.63
332.46
g/l
0.61
208
2076
37
375
0.98
0.00
2.6
2.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
256
2559
1.01
-0.00
48.9
20.7
89.95
90.16
fl
0.28
256
2542
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
256
2560
1.00
-0.00
50.4
21.3
40.33
40.33
%
0.00
256
2542
0
6
0.00
-0.00
0.0
1.2
—
29.83
—
0
6
0
9
0.00
-0.00
0.0
2.6
—
1.92
—
0
9
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_COMPLEMENTDEF and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have D3_COMPLEMENTDEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: D3_COMPLEMENTDEF – Defects in the complement system
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data