Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E55
  • Hospital discharge: ICD-9 268
  • Hospital discharge: ICD-8 265
  • Cause of death: ICD-10 E55
  • Cause of death: ICD-9 268
  • Cause of death: ICD-8 265

2 out of 7 registries used, show all original rules.

849

4. Check minimum number of events

None

849

5. Include endpoints

None

849

6. Filter based on genotype QC (FinnGen only)

719

Control definitions (FinnGen only)

Control exclude
E4_NUTRIDEF

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E50-E64
Name in latin
Deficientia vitamini D

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5671 3233 2399
Only index persons 5177 2942 2235
Unadjusted period prevalence (%)
Whole population 0.08 0.09 0.07
Only index persons 0.10 0.11 0.09
Median age at first event (years)
Whole population 44.36 48.89 38.37
Only index persons 43.19 47.31 37.76

-FinnGen-

Key figures

All Female Male
Number of individuals 719 464 255
Unadjusted period prevalence (%) 0.15 0.16 0.12
Median age at first event (years) 51.18 48.44 56.16

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
783
Matched controls
7830
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E55.9
ICD-10 Finland
Vitamin D deficiency, unspecified
4201.6
307.7
637
9
E66.8
ICD-10 Finland
Other obesity
23.9
98.7
72
33
E66.01
ICD-10 Finland
Obesity due to excess calories
8.1
76.4
111
157
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.4
60.9
352
1513
E66.9
ICD-10 Finland
Obesity, unspecified
20.7
58.5
45
23
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
13.5
55.1
53
42
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.0
46.4
294
1294
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
6.1
42.2
77
137
E66.00
ICD-10 Finland
Metabolic syndrome
8.4
37.5
50
63
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
5.9
36.0
68
125
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
12.7
33.4
33
27
AA1AD
NOMESCO Finland
CT of head and brain
2.6
33.3
261
1248
2680A
ICD-9 Finland
Vitamin D deficiency, Rickets, active
+∞
31.5
30
*
R4190
NOMESCO Finland
Nutritional therapy
5.2
31.0
66
135
E55.0
ICD-10 Finland
Rickets, active
+∞
30.4
29
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
30.2
394
2352
E55
ICD-10 Finland
Vitamin D deficiency
47.0
29.9
36
8
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.8
29.5
98
284
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
11.5
29.5
31
28
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.1
28.7
136
494
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.1
26.2
121
432
A11CC03
ATC
alfacalcidol; systemic
6.7
25.9
42
66
E83.51
ICD-10 Finland
Hypocalcemia
31.2
25.2
33
11
N06AX16
ATC
venlafaxine; oral
2.7
24.7
159
678
N06AX21
ATC
duloxetine; oral
2.9
24.6
131
506
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
24.5
147
605
E21.0
ICD-10 Finland
Primary hyperparathyroidism
7.4
23.9
35
49
N03AX12
ATC
[U] gabapentin; oral
2.7
23.9
157
676
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
7.3
23.5
35
50
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.7
23.5
148
624
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
23.3
196
947
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.9
23.1
125
486
H03AA01
ATC
levothyroxine sodium; systemic
2.3
23.0
214
1081
E53.8
ICD-10 Finland
Deficiency of other specified B group vitamins
67.1
23.0
26
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.1
22.9
104
366
T82
ICPC
Obesity
5.1
22.3
48
99
C03CA01
ATC
furosemide; systemic
2.3
22.3
209
1058
L28
ICPC
Limited function/disability (L)
2.5
22.1
164
747
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.5
22.1
81
250
26500
ICD-8 Finland
Vitamin D deficiency, Rickets active
+∞
22.0
21
*
D64.9
ICD-10 Finland
Anaemia, unspecified
3.1
21.6
98
345
A01
ICPC
Pain general/multiple sites
2.9
21.5
113
432
A02BC02
ATC
pantoprazole; systemic
2.1
21.4
536
3936
E83.39
ICD-10 Finland
Other disorder of phosphorus metabolism
+∞
20.9
20
*
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
+∞
20.9
20
*
N03AX16
ATC
[U] pregabalin
2.3
20.9
201
1025
ZX120
NOMESCO Finland
Intravenous
3.1
20.8
96
341
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
20.6
207
1075
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.3
20.0
79
255
N02AX02
ATC
tramadol; systemic, rectal
2.0
19.7
334
2109
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.0
19.6
43
90
M79.7
ICD-10 Finland
Fibromyalgia
4.3
18.9
50
122
SPAT1229
SPAT
Assessment of need for aid
3.5
18.9
67
202
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.4
18.9
144
661
N06AB04
ATC
citalopram; systemic
2.3
18.7
177
892
N06AX11
ATC
mirtazapine; oral
2.0
18.3
295
1820
Z72.0
ICD-10 Finland
Tobacco use
5.2
18.3
38
76
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
5.6
18.2
35
65
N05AH04
ATC
quetiapine; oral
2.2
17.9
183
951
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.6
17.7
110
457
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
17.5
332
2155
B03BA03
ATC
hydroxocobalamin; parenteral
4.0
17.5
51
134
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.2
17.3
176
912
RD210, ,
NOMESCO Finland
6.2
17.0
29
48
SPAT1301
SPAT
No procedures
2.0
16.9
264
1602
SPAT1249
SPAT
Treatment-related counselling outside office
1.9
16.8
323
2100
H02AB06
ATC
prednisolone; systemic
1.9
16.8
371
2524
A41.9
ICD-10 Finland
Sepsis, unspecified
4.9
16.7
37
78
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
4.2
16.7
46
116
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.2
16.6
159
803
SPAT1254
SPAT
Administration of medicine
2.3
16.4
137
652
E87.6
ICD-10 Finland
Hypokalaemia
4.3
16.3
43
105
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.2
16.1
66
218
N06AB10
ATC
escitalopram; oral
2.0
15.9
203
1142
SPAT1260
SPAT
Consultation of another employee
2.2
15.9
155
787
C03DA01
ATC
spironolactone; oral
2.6
15.7
96
395
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
15.6
125
583
UJF32
NOMESCO Finland
Coloscopy
2.1
15.6
196
1095
SPAT1255
SPAT
Intravenous administration of medicine
3.3
15.4
60
192
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.0
15.1
68
237
A09AA02
ATC
multienzymes (lipase, protease etc.); oral
5.1
15.1
32
65
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.8
15.1
78
294
L04AX01
ATC
azathioprine; systemic
3.8
14.7
46
127
R06.0
ICD-10 Finland
Dyspnoea
2.0
14.7
219
1297
SPAT1310
SPAT
Counselling related to known health issue
1.9
14.6
267
1690
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
+∞
14.6
14
*
-, ,
ICD-10 Finland
5.2
14.4
30
60
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.5
14.4
96
412
R52.2
ICD-10 Finland
Other chronic pain
3.6
14.2
47
135
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.9
14.1
247
1540
N02BF02
ATC
pregabalin; oral
2.8
13.9
72
272
E21.1
ICD-10 Finland
Secondary hyperparathyroidism, not elsewhere classified
54.4
13.9
16
*
N02AA05
ATC
oxycodone; systemic
2.2
13.8
133
669
R51.80
ICD-10 Finland
Headache
2.1
13.8
163
887
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.1
13.7
58
195
G47.3
ICD-10 Finland
Sleep apnoea
2.0
13.7
167
920
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.6
13.6
46
134
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.9
13.6
66
240
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.4
13.6
97
429
R10.0
ICD-10 Finland
Acute abdomen
4.1
13.5
37
93
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.9
13.4
40
107
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.9
13.4
216
1309
N03AE01
ATC
clonazepam; systemic
3.2
13.3
54
177
SPAT1172
SPAT
Guidance concerning hydration
5.9
13.3
24
42
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.2
13.1
35
86
K92.1
ICD-10 Finland
Melaena
3.4
13.1
48
148
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.3
13.1
111
530
JN3AD
NOMESCO Finland
Abdominal CT examination
2.3
13.0
109
517
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.2
12.9
122
608
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.2
12.9
53
175
A28
ICPC
Limited function/disability NOS
2.1
12.9
129
658
P29
ICPC
Psychological sympt/compl other
2.5
12.8
88
382
SPAT1216
SPAT
Assessment of functional ability
2.2
12.8
114
555
B81
ICPC
Anaemia vit B12/folate deficiency
4.1
12.8
35
88
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.0
12.7
164
919
E86
ICD-10 Finland
Volume depletion
5.3
12.6
25
48
A12AA04
ATC
calcium carbonate; oral
6.3
12.5
21
34
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
5.1
12.5
26
52
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.2
12.5
113
554
E83.50
ICD-10 Finland
Hypercalcemia
9.9
12.3
24
25
R11
ICD-10 Finland
Nausea and vomiting
2.4
12.3
92
416
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.6
12.2
74
303
M54.5
ICD-10 Finland
Low back pain
1.7
12.1
297
2030
SPAT1240
SPAT
Therapeutic discussion
2.2
12.1
108
526
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.0
12.0
55
194
SPAT1262
SPAT
Handing over of treatment supplies
2.1
11.8
118
600
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.7
11.8
68
271
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
4.7
11.7
27
59
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.4
11.6
83
367
WZC00, ,
SPAT
2.0
11.6
136
735
M81.8
ICD-10 Finland
Other osteoporosis
9.4
11.6
23
25
SPAT1263
SPAT
Sampling
1.7
11.5
331
2356
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.6
11.5
70
287
E83.30
ICD-10 Finland
Acid phosphatase deficiency
+∞
11.5
11
*
E61.2
ICD-10 Finland
Magnesium deficiency
+∞
11.5
11
*
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.9
11.5
161
926
E66.0
ICD-10 Finland
Obesity due to excess calories
121.7
11.5
12
*
A04
ICPC
Weakness/tiredness general
2.0
11.4
146
813
A10AE04
ATC
insulin glargine; parenteral
2.5
11.4
75
319
ZY010
NOMESCO Finland
Hospital outpatient
2.7
11.4
63
246
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.2
11.4
103
504
103
Kela drug reimbursment
Diabetes, insulin-treated
1.9
11.3
170
1000
N03AG01
ATC
valproic acid; systemic, rectal
2.7
11.3
63
247
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.2
11.3
44
141
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
11.3
151
855
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.1
11.2
111
563
Z3231
NOMESCO Finland
Registered nurse
1.8
11.2
212
1340
Z2445
NOMESCO Finland
Psychologist
3.0
11.2
50
174
R02
ICPC
Shortness of breath/dyspnoea
2.1
11.1
118
615
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.6
11.0
65
262
M79.6
ICD-10 Finland
Pain in limb
1.7
11.0
350
2549
R51
ICD-10 Finland
Headache
2.6
11.0
64
257
V03AG01
ATC
sodium cellulose phosphate; systemic
44.0
10.9
13
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.7
10.8
59
229
ZX114
NOMESCO Finland
Intramuscular
5.0
10.8
23
47
WZC00
NOMESCO Finland
Treatment plan or consultation
1.7
10.8
299
2100
Z3229
NOMESCO Finland
Other healthcare associate professional
2.5
10.7
70
297
N06AB06
ATC
sertraline; oral
2.1
10.7
113
587
N05AA02
ATC
levomepromazine; systemic
3.4
10.7
39
120
N05CF01
ATC
zopiclone; oral
1.7
10.7
229
1498
I95.9
ICD-10 Finland
Hypotension, unspecified
5.4
10.6
21
40
N02BE01
ATC
paracetamol; systemic, rectal
2.1
10.6
685
6033
D01
ICPC
Abdominal pain/cramps general
2.0
10.5
123
664
N03AX09
ATC
lamotrigine; oral
2.7
10.5
56
215
26599
ICD-8 Finland
Vitamin D deficiency, Unspecified
+∞
10.4
10
*
26510
ICD-8 Finland
Vitamin D deficiency, Rickets, late effect
+∞
10.4
10
*
N05AH03
ATC
olanzapine; systemic
2.5
10.4
68
288
E66
ICD-10 Finland
Obesity
3.0
10.4
46
159
P03
ICPC
Feeling depressed
2.1
10.4
106
543
C08CA01
ATC
amlodipine; oral
1.7
10.4
239
1592
UJF92
NOMESCO Finland
Capsular endoscopy
4.4
10.4
26
61
B01AB05
ATC
enoxaparin; parenteral
1.8
10.3
212
1367
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.5
10.3
35
103
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
10.2
168
1013
SPAT1312
SPAT
General health counselling
1.7
10.2
259
1771
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
10.2
209
1348
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
10.1
183
1136
R53
ICD-10 Finland
Malaise and fatigue
1.7
10.1
213
1382
R60.0
ICD-10 Finland
Localized oedema
2.1
10.1
97
485
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.1
10.1
104
535
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.0
10.0
119
644
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.3
10.0
38
120
C10AC01
ATC
colestyramine; oral
3.8
10.0
30
81
F32
ICD-10 Finland
Depressive episode
2.6
9.9
58
233
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.5
9.9
63
264
NH1AD
NOMESCO Finland
Ankle and foot CT
4.5
9.9
24
55
N05BA04
ATC
oxazepam; oral
1.7
9.8
206
1334
M25.5
ICD-10 Finland
Pain in joint
1.7
9.8
269
1874
L04AX03
ATC
methotrexate; systemic
2.2
9.7
84
403
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.7
9.7
54
212
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.9
9.7
46
166
P76
ICPC
Depressive disorder
2.3
9.6
73
331
K59.09
ICD-10 Finland
Constipation, unspecified
2.5
9.6
60
249
ZXD05
NOMESCO Finland
Urgent procedure
1.7
9.6
226
1510
F61.0
ICD-10 Finland
Mixed personality disorders
4.7
9.6
22
48
G35
ICD-10 Finland
Multiple sclerosis
4.7
9.6
22
48
I10
ICD-10 Finland
Essential (primary) hypertension
1.6
9.6
372
2819
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
9.5
337
2495
J45.1
ICD-10 Finland
Nonallergic asthma
2.4
9.5
65
282
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
4.0
9.5
27
70
E83.4
ICD-10 Finland
Disorders of magnesium metabolism
30.4
9.4
12
*
J46
ICD-10 Finland
Status asthmaticus
3.8
9.4
28
75
JDF01
NOMESCO Finland
Laparoscopic gastroplasty
+∞
9.4
9
*
E21.2
ICD-10 Finland
Other hyperparathyroidism
22.0
9.4
13
6
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
9.4
319
2339
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
9.3
422
3311
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
9.3
78
370
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.5
9.2
60
254
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.3
9.2
70
318
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
4.0
9.2
26
67
A07EC01
ATC
sulfasalazine; oral, rectal
2.4
9.2
67
299
A46
ICD-10 Finland
Erysipelas
2.1
9.1
97
504
E87.5
ICD-10 Finland
Hyperkalaemia
4.9
9.1
20
42
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
2.5
9.0
58
244
T90
ICPC
Diabetes non-insulin dependent
1.8
9.0
144
859
WW200
NOMESCO Finland
Immunization
3.8
9.0
27
73
F29
ICD-10 Finland
Unspecified nonorganic psychosis
2.9
8.9
43
156
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
4.4
8.9
22
51
F10.25
ICD-10 Finland
Alcohol dependence continuous use
4.4
8.9
22
51
Z2446
NOMESCO Finland
Social worker
2.4
8.9
65
290
SPAT1252
SPAT
Overall medication plan or its review
2.6
8.9
51
203
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
8.9
157
965
N18.8
ICD-10 Finland
Other chronic renal failure
4.7
8.9
20
43
P01AB01
ATC
metronidazole; oral, rectal
1.6
8.9
296
2153
WVA20
NOMESCO Finland
Medicine administration
3.5
8.8
30
88
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
3.9
8.8
26
69
JN4AD
NOMESCO Finland
Body CT examination
2.2
8.8
80
391
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.1
8.8
87
440
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.2
8.7
77
372
JAH01
NOMESCO Finland
Laparoscopy
2.8
8.7
43
158
A10BA02
ATC
metformin; oral
1.8
8.7
166
1042
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
8.7
145
875
F10.09
ICD-10 Finland
Alcohol intoxication UNS
3.8
8.7
26
70
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.2
8.7
75
360
L04AA06
ATC
mycophenolic acid; systemic
4.5
8.7
21
48
EBA00
NOMESCO Finland
Extraction of tooth
1.6
8.7
301
2207
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
4.6
8.6
20
44
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
8.6
245
1711
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
8.6
112
625
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
3.2
8.6
33
105
M13.9
ICD-10 Finland
Arthritis, unspecified
2.3
8.6
63
282
KA1AE
NOMESCO Finland
Kidney ultrasound examination
4.1
8.6
23
57
UJK02
NOMESCO Finland
ERCP
4.1
8.6
23
57
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.6
8.6
50
201
Z71.8
ICD-10 Finland
Other specified counselling
1.6
8.5
282
2042
R03DA04
ATC
theophylline; systemic, rectal
2.8
8.5
41
149
Q79.6
ICD-10 Finland
Ehlers-Danlos syndrome
27.8
8.5
11
*
P01
ICPC
Feeling anxious/nervous/tense
1.8
8.5
139
835
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
4.0
8.5
24
62
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
3.6
8.5
27
76
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
3.8
8.4
25
67
R4180
NOMESCO Finland
Podiatric therapy
5.0
8.4
18
37
E83.3
ICD-10 Finland
Disorders of phosphorus metabolism and phosphatases
+∞
8.3
8
*
M83.9
ICD-10 Finland
Adult osteomalacia, unspecified
+∞
8.3
8
*
WZC30
NOMESCO Finland
Teaching
1.9
8.3
120
692
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.2
8.3
75
366
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
4.2
8.3
22
54
N05AX08
ATC
risperidone; systemic
2.2
8.2
72
347
R42
ICD-10 Finland
Dizziness and giddiness
1.7
8.2
163
1034
SPAT1211
SPAT
Application of soft bandage
2.2
8.2
73
354
N06AX03
ATC
mianserin; oral
2.8
8.2
41
152
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
7.6
8.2
18
24
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
3.0
8.2
35
119
B80
ICPC
Iron deficiency anaemia
3.5
8.2
27
78
K04.08
ICD-10 Finland
Other specified pulpit
2.1
8.1
75
369
A10AB05
ATC
insulin aspart; parenteral
2.3
8.1
60
269
IGY02, ,
SPAT
4.1
8.1
22
55
D12
ICPC
Constipation
3.0
8.1
35
120
T36
ICD-10 Finland
Poisoning by systemic antibiotics
2.6
8.1
45
177
XPX04
NOMESCO Finland
Angioscopy
22.3
8.0
11
5
WZA90
NOMESCO Finland
Other medical or dental certificate
1.7
8.0
197
1323
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.2
8.0
72
351
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
3.3
8.0
29
89
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.2
8.0
70
338
R50.9
ICD-10 Finland
Fever, unspecified
1.8
7.9
121
710
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.7
7.9
41
155
A03
ICPC
Fever
1.7
7.9
163
1044
A02BC03
ATC
lansoprazole; oral
1.7
7.9
194
1302
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
7.9
154
972
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.2
7.9
69
333
SPAT1283
SPAT
Restricted health certificate
1.7
7.9
162
1038
XA800
NOMESCO Finland
Neuropsychological investigation
2.7
7.8
41
156
C07AB07
ATC
bisoprolol; oral
1.6
7.8
300
2239
C09AA02
ATC
enalapril; systemic
1.9
7.8
113
653
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.3
7.8
56
249
F99
ICD-10 Finland
Mental disorder, not otherwise specified
3.6
7.7
25
71
N03AX11
ATC
topiramate; oral
3.3
7.7
29
91
P99
ICPC
Psychological disorders other
2.9
7.7
35
123
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
7.7
200
1359
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.8
7.7
120
708
K02.1
ICD-10 Finland
Caries of dentine
1.5
7.7
476
3930
H02AB09
ATC
hydrocortisone; systemic
3.4
7.7
27
81
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.4
7.7
51
218
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
3.1
7.7
32
107
L03
ICPC
Low back symptom/complaint
1.6
7.7
228
1602
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
4.0
7.7
21
53
SPAT1167
SPAT
Insertion of urinary catheter
4.0
7.7
21
53
ZYC01
NOMESCO Finland
Remote contact by phone
2.3
7.6
59
270
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
2.8
7.6
37
135
F41.09
ICD-10 Finland
UNS Panic Syndrome
2.9
7.6
35
124
J01FF01
ATC
clindamycin; systemic
1.6
7.6
192
1296
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.8
7.6
120
712
A29
ICPC
General symptom/complaint other
1.9
7.6
104
590
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.0
7.6
83
436
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
7.6
319
2424
TAB00
NOMESCO Finland
Lumbar puncture
2.5
7.6
47
195
TPH07
NOMESCO Finland
Cathetrisation of artery
2.1
7.6
77
394
N06AX12
ATC
bupropion; oral
2.1
7.5
69
340
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
3.6
7.5
24
68
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.9
7.5
104
593
RS221, ,
NOMESCO Finland
4.5
7.5
18
41
ZXE20
NOMESCO Finland
More than three and less than five hours
1.9
7.4
97
541
RD130, ,
NOMESCO Finland
80.8
7.4
8
*
N01
ICPC
Headache
1.8
7.4
122
732
NHQ40
NOMESCO Finland
Amputation of toe
7.8
7.4
16
21
J01MA12
ATC
levofloxacin; systemic
1.8
7.3
117
696
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
2.8
7.3
35
127
K08.3
ICD-10 Finland
Retained dental root
2.2
7.3
60
282
26520
ICD-8 Finland
Vitamin D deficiency, Osteomalacia
+∞
7.3
7
*
D06
ICPC
Abdominal pain localized other
2.0
7.3
76
392
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.1
7.3
74
378
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
3.9
7.3
21
55
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.8
7.3
105
605
SGA01
NOMESCO Finland
Emergency treatment
1.7
7.3
135
839
127
Kela drug reimbursment
Transplant complication
4.4
7.2
18
42
K04.7
ICD-10 Finland
Periapical abscess without sinus
2.4
7.2
50
218
XG466
NOMESCO Finland
Sleep oxymetry
3.7
7.2
22
60
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.8
7.2
113
668
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
2.5
7.2
44
181
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.8
7.2
35
128
N06AB03
ATC
fluoxetine; oral
1.9
7.2
96
540
R96
ICPC
Asthma
2.0
7.1
75
388
SPAT1210
SPAT
Application of cast or individual aid
2.7
7.1
38
146
L17
ICPC
Foot/toe symptom/complaint
1.6
7.1
226
1608
P01BA02
ATC
hydroxychloroquine; oral
2.1
7.1
65
319
M35.7
ICD-10 Finland
Hypermobility syndrome
4.1
7.1
19
47
G43.9
ICD-10 Finland
Migraine, unspecified
2.2
7.1
63
306
A02BC01
ATC
omeprazole; systemic
1.6
7.1
186
1266
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
3.3
7.0
26
81
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.5
7.0
415
3368
WX110
NOMESCO Finland
Infiltration anesthesia
1.6
7.0
560
4838
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
3.1
7.0
29
97
R5110, ,
SPAT
2.2
7.0
62
301
XF600, ,
SPAT
2.9
7.0
31
108
N06AA09
ATC
amitriptyline; systemic
2.1
7.0
64
315
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.0
6.9
81
435
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
6.9
226
1618
NG4AA
NOMESCO Finland
Lower leg X-ray examination
2.8
6.9
33
120
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
3.0
6.9
29
98
OAB43, ,
SPAT
0.6
6.8
155
2248
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.3
6.8
50
224
M05BA04
ATC
alendronic acid; oral
2.2
6.8
57
270
A05AA02
ATC
ursodeoxycholic acid; oral
3.7
6.8
21
58
OAA68, ,
SPAT
4.3
6.8
17
40
M81.0
ICD-10 Finland
Postmenopausal osteoporosis
3.2
6.8
26
83
D52.0
ICD-10 Finland
Dietary folate deficiency anaemia
40.4
6.8
8
*
TQW80
NOMESCO Finland
Local dermatologic skincare
3.6
6.8
22
63
J01MA02
ATC
ciprofloxacin; systemic
1.5
6.7
252
1857
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
6.7
139
889
R33
ICD-10 Finland
Retention of urine
2.4
6.7
46
200
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.5
6.7
40
163
R03AC02
ATC
salbutamol; inhalant
1.5
6.7
420
3436
SGB10
NOMESCO Finland
Root filling of tooth with one root canal
1.9
6.7
91
515
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.4
6.7
47
207
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
4.1
6.7
18
45
Z02.7
ICD-10 Finland
Issue of medical certificate
2.1
6.6
61
300
W17
ICD-10 Finland
Other fall from one level to another
2.7
6.6
35
134
L16
ICPC
Ankle symptom/complaint
1.8
6.6
102
600
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.9
6.6
78
421
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.4
6.6
23
69
IGV01
NOMESCO Finland
Psychiatric network contact
4.2
6.6
17
41
K56.7
ICD-10 Finland
Ileus, unspecified
4.2
6.6
17
41
D09
ICPC
Nausea
2.2
6.6
52
241
SPAT1215
SPAT
Assessment of need for medical rehabilitation
2.7
6.6
34
129
F20.0
ICD-10 Finland
Paranoid schizophrenia
10.1
6.5
12
12
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
3.7
6.5
20
55
I50.0
ICD-10 Finland
Congestive heart failure
2.4
6.5
43
184
C07AB02
ATC
metoprolol; systemic
1.7
6.5
116
712
D50.8
ICD-10 Finland
Other iron deficiency anaemias
5.4
6.5
18
34
R5599
NOMESCO Finland
Other rehabilitation service
2.9
6.5
30
107
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
3.6
6.5
21
60
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
3.3
6.5
24
75
A10BK01
ATC
dapagliflozin; oral
2.3
6.5
47
210
B02AA02
ATC
tranexamic acid; systemic
1.8
6.4
109
659
N06AX26
ATC
vortioxetine; oral
2.0
6.4
70
367
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.7
6.4
124
778
N05BA01
ATC
diazepam; systemic, rectal
1.8
6.4
90
515
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
2.6
6.4
37
149
I50.9
ICD-10 Finland
Heart failure, unspecified
1.9
6.4
76
412
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.8
6.3
31
114
S18
ICPC
Laceration/cut
1.5
6.3
325
2547
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
3.5
6.3
21
61
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
3.9
6.3
18
47
N07BB01
ATC
disulfiram; oral
2.6
6.3
35
138
BBA20
NOMESCO Finland
Exploration of parathyroid gland
18.2
6.3
9
5
A07AA02
ATC
nystatin; oral
2.4
6.3
42
181
RD140, ,
NOMESCO Finland
+∞
6.3
6
*
2682A
ICD-9 Finland
Vitamin D deficiency, Osteomalacia, unspecified[OSTEOMALACIA]
+∞
6.3
6
*
D55.9
ICD-10 Finland
Anaemia due to enzyme disorder, unspecified
+∞
6.3
6
*
M13.8
ICD-10 Finland
Other specified arthritis
7.1
6.2
14
20
A10AC01
ATC
insulin (human); parenteral
2.2
6.2
53
253
N05AX12
ATC
aripiprazole; systemic
2.4
6.2
40
169
AN1
HP
Coronary angiography
2.1
6.2
60
301
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.4
6.2
42
182
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
4.0
6.2
17
43
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.7
6.2
112
690
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
3.6
6.2
20
57
L11
ICPC
Wrist symptom/complaint
1.9
6.2
81
453
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
7.8
6.1
13
17
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.7
6.1
32
122
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.4
6.1
42
183
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.6
6.1
33
128
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
4.2
6.1
16
39
B01AA03
ATC
warfarin; systemic
1.8
6.1
96
568
SPAT1104
SPAT
Monitoring of emergency patient
2.3
6.1
43
190
B01AC04
ATC
clopidogrel; oral
1.8
6.1
93
546
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.4
6.1
39
165
R1240
NOMESCO Finland
Social assessment of need and possibilities of rehabilitation
6.8
6.1
14
21
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
10.1
6.0
11
11
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
5.2
6.0
17
33
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.5
6.0
274
2092
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.2
6.0
47
217

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
643
2977
7.49
124.46
5.1
2.4
59.90
76.67
nmol/l
38.73
613
2737
227
456
6.60
114.40
5.0
4.1
89.98
80.05
ng/l
0.77
194
408
287
763
5.36
105.45
7.7
6.1
1.04
1.05
mmol/l
0.22
267
706
612
3032
5.66
99.57
11.9
7.0
1.22
1.22
mmol/l
0.02
550
2632
543
2703
4.29
80.90
10.2
6.4
1.21
1.22
mmol/l
0.98
515
2501
417
1860
3.66
70.20
6.0
3.9
7.39
7.40
ph
0.30
333
1318
511
2625
3.73
68.29
7.1
4.7
34.97
36.58
g/l
7.33
486
2470
269
967
3.71
61.83
5.8
3.6
0.80
0.82
mmol/l
2.25
251
930
83
107
8.56
61.48
2.7
1.9
4.78
4.73
mmol/24h
0.05
71
94
413
2154
2.94
48.06
3.3
3.3
2.34
2.36
mmol/l
1.09
384
1973
248
986
3.22
46.77
3.4
2.5
12.07
13.82
umol/l
2.88
239
917
231
907
3.19
44.19
3.4
2.4
2.28
2.34
g/l
0.66
223
845
338
1640
2.87
44.12
3.0
2.1
3.05
2.72
mg/l
1.63
308
1421
685
4883
4.22
43.69
13.4
7.5
87.33
76.81
u/l
4.89
672
4638
529
3259
2.92
43.23
9.6
6.1
10.99
11.04
umol/l
0.04
502
3108
364
1863
2.78
42.51
3.2
2.1
195.39
175.56
u/l
0.23
352
1771
215
829
3.20
42.20
3.3
2.5
21.02
23.46
%
1.53
207
778
183
646
3.39
41.49
2.7
2.1
356.51
387.06
nmol/l
1.30
173
613
560
3607
2.94
41.11
10.2
6.5
0.19
0.19
e9/l
0.06
495
3163
547
3495
2.87
40.49
9.3
6.2
0.04
0.04
e9/l
0.24
484
3018
546
3488
2.87
40.38
9.3
6.2
0.56
0.55
e9/l
0.35
485
3012
239
1014
2.95
39.31
1.5
1.4
424.56
489.33
titre
0.32
57
223
340
1740
2.69
38.90
2.3
1.6
16.48
20.37
nmol/l
5.61
311
1495
370
1978
2.65
38.68
4.6
2.5
58.63
64.74
u/l
0.80
352
1851
68
118
6.22
38.17
3.9
3.2
9.82
7.54
pmol/l
1.23
68
118
448
2641
2.63
38.06
2.8
1.9
88.22
97.28
pmol/l
4.23
301
1382
169
600
3.32
37.68
6.4
3.6
5.79
5.74
kpa
0.23
164
583
575
3862
2.84
36.98
13.7
9.2
4.15
3.95
e9/l
1.29
521
3366
546
3578
2.74
36.78
9.4
6.2
1.91
1.94
e9/l
0.20
496
3166
139
452
3.52
35.50
1.9
2.6
65.82
67.53
g/l
1.73
128
423
550
3661
2.69
35.12
8.6
4.7
6.78
6.46
mmol/l
1.86
527
3415
150
518
3.34
34.80
5.9
3.1
4.57
4.56
kpa
0.03
145
503
189
749
3.01
34.69
9.4
7.4
104.66
104.36
mmol/l
0.36
189
749
160
577
3.23
34.55
6.6
3.7
1.58
1.68
mmol/l
0.12
131
491
156
562
3.22
33.69
3.2
2.9
10.38
10.51
g/l
0.16
142
517
162
599
3.15
33.46
6.5
3.7
7.37
7.38
ph
1.37
100
345
144
497
3.32
33.35
9.9
7.6
8.86
8.47
mmol/l
0.28
139
478
432
2621
2.45
32.78
19.2
11.6
1.23
1.19
inr
1.04
376
2167
301
1565
2.50
31.96
6.4
4.1
—
—
—
0
0
148
533
3.19
31.87
3.5
2.4
0.19
0.22
g/l
6.00
137
500
205
888
2.77
31.61
2.2
1.7
1276.08
1214.87
nmol/l
0.27
166
664
288
1505
2.45
29.85
3.3
2.7
337.04
330.99
umol/l
0.39
254
1363
141
540
2.96
27.02
9.4
7.8
1.69
1.31
mmol/l
1.67
136
531
267
1404
2.37
26.75
3.8
2.7
7.15
6.89
e6/l
0.09
254
1274
238
1210
2.39
25.57
2.9
2.7
2.44
2.44
mmol/l
0.06
217
1090
472
3192
2.21
25.03
9.4
6.3
2.68
2.82
%
0.68
447
3010
471
3194
2.19
24.65
9.5
6.4
8.69
8.68
%
0.01
445
3017
84
248
3.67
24.52
5.1
3.9
36.91
36.93
°c
0.22
84
248
146
603
2.75
24.14
8.4
9.1
5.04
5.01
kpa
0.10
140
578
146
603
2.75
24.14
8.4
9.1
12.09
12.51
kpa
0.41
140
580
236
1226
2.32
23.89
2.0
1.6
64039802.50
33525893.45
pmol/l
0.19
203
1041
143
591
2.74
23.58
8.4
9.3
1.05
0.74
mmol/l
0.30
113
485
472
3241
2.15
23.43
9.2
6.2
56.87
56.68
%
0.13
455
3112
466
3187
2.14
23.34
9.6
6.4
0.65
0.69
%
0.85
439
2998
340
2063
2.15
23.33
5.6
3.2
73.03
82.23
e6/l
0.07
295
1535
325
1938
2.16
23.32
4.3
2.9
—
—
—
0
0
507
3584
2.18
23.27
6.4
3.7
0.01
0.00
estimate
0.39
118
751
510
3616
2.18
23.19
6.4
3.7
44.94
6.57
estimate
0.82
119
762
168
759
2.54
23.11
2.0
1.6
—
—
—
0
0
512
3646
2.17
22.88
6.5
3.7
0.01
0.42
estimate
0.50
114
731
118
447
2.93
22.87
2.3
1.7
1.19
1.35
g/l
0.65
108
409
107
384
3.07
22.82
5.7
3.7
7.41
7.42
ph
1.06
89
320
37
58
6.65
22.81
1.8
1.1
121.70
106.97
pmol/l
0.76
37
58
289
1661
2.17
22.65
1.9
1.4
2.45
2.26
g/l
1.07
192
1051
106
380
3.07
22.64
1.6
2.2
—
—
—
0
0
279
1582
2.19
22.62
3.7
3.1
1980.31
1071.72
ng/l
1.29
238
1315
126
498
2.82
22.57
4.8
2.4
0.37
0.52
e6/l
0.27
117
476
284
1624
2.17
22.52
6.2
3.7
1.02
1.02
kg/l
0.84
203
1054
120
463
2.88
22.48
5.7
3.5
1.21
1.23
mmol/l
2.18
109
397
89
289
3.35
22.40
1.4
1.2
2.28
2.23
u/ml
0.01
11
13
144
613
2.65
22.32
2.9
3.2
1.99
1.78
%
1.05
132
555
141
598
2.66
22.00
8.5
9.3
7.41
7.42
ph
0.16
87
328
327
1990
2.10
21.92
6.4
3.8
0.00
0.01
estimate
0.99
106
724
92
310
3.23
21.80
2.1
2.1
5.67
7.65
iu/ml
0.24
36
67
430
2900
2.07
21.77
5.3
3.3
6.31
6.22
ph
0.96
253
1642
352
2207
2.08
21.73
5.0
3.0
30.68
31.63
u/l
0.27
331
2110
471
3298
2.07
21.35
9.5
6.2
28.25
28.69
%
0.37
454
3143
110
417
2.91
21.23
3.4
3.4
4.36
4.58
pmol/l
1.24
94
376
89
299
3.23
21.18
6.7
2.7
0.65
0.60
%
1.02
89
299
376
2437
2.04
20.98
6.7
3.8
110.91
98.43
e6/l
0.08
307
1656
224
1193
2.23
20.98
5.7
2.8
542.99
534.43
mosm/kgh2o
0.21
204
1036
129
537
2.68
20.83
8.7
9.8
95.42
95.65
%
0.15
123
519
296
1772
2.08
20.40
5.3
3.1
0.58
0.39
e6/l
0.82
248
1257
443
3065
2.03
20.38
19.1
10.2
0.00
0.00
e9/l
0.57
378
2520
27
34
8.19
20.12
1.8
2.0
68.26
68.99
ug/l
0.01
27
34
185
926
2.31
20.00
2.7
2.1
29.80
29.08
s
1.00
175
898
311
1907
2.05
19.98
1.5
1.4
1.93
1.71
u/ml
0.07
97
533
660
5338
2.51
19.90
6.8
4.3
14.77
14.63
pmol/l
0.78
626
4948
347
2228
2.00
19.46
9.1
6.3
—
—
—
0
0
481
3461
2.01
19.40
4.6
3.0
121.86
96.70
ug/l
1.88
454
3262
125
530
2.62
19.38
10.1
8.7
—
—
—
0
0
351
2281
1.98
18.84
5.5
3.4
54.04
59.33
ng/l
0.06
265
1453
121
515
2.60
18.58
9.5
10.0
121.84
120.87
g/l
0.18
116
501
61
175
3.70
18.51
1.9
3.5
32.30
51.07
mg/l
0.57
46
146
404
2770
1.95
18.38
6.5
3.5
0.01
0.03
estimate
0.68
98
637
49
121
4.25
18.27
3.7
3.3
—
—
—
0
0
114
476
2.63
18.18
2.6
3.1
73.41
71.12
e9/l
0.22
87
340
317
2009
1.97
18.13
4.7
3.3
7.60
7.86
mmol/l
0.40
284
1724
60
175
3.63
17.76
1.9
3.5
35.88
80.50
mg/l
0.70
45
148
68
220
3.29
17.15
6.9
4.8
1.60
1.38
mg/l
1.62
63
197
749
6605
4.09
16.66
31.6
14.8
139.40
139.68
mmol/l
2.10
741
6470
55
158
3.67
16.65
1.9
3.3
1.19
2.57
ratio
1.56
30
91
749
6614
4.05
16.43
31.8
15.0
3.93
3.94
mmol/l
0.88
741
6457
123
568
2.38
15.75
5.8
4.4
1.02
1.00
%
0.04
40
161
68
239
3.02
14.92
5.4
6.4
1.51
1.52
%
0.04
62
221
117
541
2.37
14.90
6.0
4.4
0.09
0.13
%
0.32
33
134
246
1513
1.91
14.76
2.3
1.7
1.27
1.09
mg/l
0.43
194
1142
80
310
2.76
14.69
7.6
8.1
24.23
24.24
mmol/l
0.01
75
294
715
6226
2.71
14.60
8.1
5.2
2.35
1.85
mu/l
0.51
683
5851
83
329
2.70
14.59
2.4
1.6
0.35
0.28
mg/l
0.44
37
153
61
204
3.16
14.56
2.5
1.9
1.37
2.42
ug/l
0.34
56
187
552
4367
1.89
14.56
7.0
4.4
849.40
1987.54
e6/l
—
10
61
100
436
2.48
14.48
2.7
2.4
6.42
7.32
ug/l
0.23
84
387
73
272
2.86
14.43
6.2
3.8
—
—
—
0
0
745
6656
3.46
13.96
28.7
13.3
20.59
22.64
mg/l
1.34
666
5329
56
183
3.22
13.89
1.7
1.5
238.28
302.84
ug/g
1.24
32
108
249
1563
1.87
13.88
7.6
3.9
88.54
92.72
%
1.68
238
1532
59
202
3.08
13.54
1.6
1.2
82.22
92.92
titre
—
9
24
65
236
2.91
13.46
1.2
1.3
—
—
—
0
0
112
537
2.27
13.05
5.8
4.2
0.44
0.61
%
0.44
32
145
185
1073
1.95
13.01
4.5
2.8
1.13
1.12
e6/l
0.01
122
539
261
1710
1.79
12.40
3.8
3.5
68.90
46.57
mg/l
0.71
185
1091
170
984
1.93
11.93
1.8
1.6
—
—
—
0
0
152
849
1.98
11.83
2.7
1.9
—
—
—
0
0
24
27
9.13
11.81
1.7
2.1
90.80
95.11
ng/l
0.07
24
27
119
611
2.12
11.64
2.3
2.1
0.07
0.04
estimate
0.29
27
140
36
99
3.76
11.62
1.3
1.3
65.85
59.38
mmol/l
0.29
27
88
214
1345
1.81
11.55
1.5
1.3
35.02
29.26
iu/ml
0.11
62
407
403
3026
1.68
11.44
3.4
2.7
—
—
estimate
—
0
0
36
102
3.65
11.14
5.4
3.7
2.46
2.28
mmol/l
0.14
24
64
176
1052
1.87
11.12
2.3
2.4
140.11
106.53
ug/g
0.43
144
843
260
1749
1.73
11.02
4.6
4.1
18.12
8.19
mg/mmol
1.58
181
1069
38
113
3.48
10.95
1.6
1.4
27.40
22.91
u/l
0.31
33
92
110
562
2.11
10.88
6.4
4.7
0.12
0.20
%
0.28
25
131
683
6003
2.08
10.73
7.5
5.3
39.48
38.06
mmol/mol
2.86
650
5687
290
2042
1.67
10.20
3.3
2.3
—
—
—
0
0
196
1245
1.77
10.03
1.5
1.3
6.52
9.67
u/ml
0.34
89
498
130
728
1.94
9.94
6.3
2.6
8.96
6.69
umol/l
0.49
109
629
28
72
4.00
9.93
1.3
1.3
—
—
—
0
0
166
1007
1.82
9.90
5.6
2.9
4.25
2.88
e6/l
0.92
101
476
563
4707
1.70
9.85
5.9
3.0
63.33
42.04
u/l
2.99
545
4487
28
73
3.94
9.75
1.3
1.3
6.25
6.64
g/l
0.19
20
53
28
73
3.94
9.75
1.3
1.3
0.33
0.36
g/l
0.20
20
52
28
73
3.94
9.75
1.3
1.3
2.60
2.61
g/l
0.00
21
52
98
501
2.09
9.65
6.3
4.3
7.35
7.34
ph
0.11
82
353
279
1983
1.63
9.26
9.8
6.1
—
—
—
0
0
36
116
3.20
9.17
3.6
2.7
0.84
0.79
nmol/l
0.20
28
100
117
663
1.90
8.58
1.6
1.5
—
—
—
0
0
98
523
2.00
8.57
1.5
1.3
208.68
221.16
u/ml
0.06
89
488
24
62
3.96
8.47
3.1
2.0
1.25
1.13
g/24h
0.09
14
39
72
344
2.20
8.41
11.8
10.9
0.69
0.63
%
0.52
72
344
73
351
2.19
8.39
11.7
10.7
1.49
1.26
%
0.87
73
351
82
414
2.10
8.33
3.4
2.2
7582.37
5831.64
u/l
0.17
28
181
20
46
4.44
8.19
1.1
1.2
0.73
0.52
ratio
1.17
12
26
138
837
1.79
8.13
3.6
3.2
4.54
5.02
e9/l
0.40
116
743
38
136
2.89
8.12
1.1
1.1
—
—
—
0
0
522
4376
1.58
8.10
5.1
3.6
—
0.14
—
0
7
54
232
2.43
8.06
1.8
2.3
1.50
1.45
g/l
0.14
48
208
18
25
7.34
7.99
1.4
1.2
137.82
150.14
nmol/l
0.24
18
25
94
508
1.97
7.92
2.5
2.4
26.91
19.26
au/ml
—
7
49
47
193
2.53
7.72
6.1
2.6
—
—
—
0
0
139
863
1.74
7.52
1.3
1.2
—
—
—
0
0
748
6981
2.60
7.52
19.3
10.5
27.16
26.08
u/l
0.81
739
6808
51
223
2.38
7.34
6.3
4.2
24.49
24.57
mmol/l
0.08
46
215
33
116
2.93
7.29
1.2
1.8
—
—
—
0
0
38
145
2.70
7.23
4.4
3.9
3.76
3.92
mmol/l
0.96
38
145
29
95
3.13
7.23
1.4
1.2
0.65
0.59
nmol/l
0.39
29
88
26
81
3.29
7.03
1.4
1.2
—
—
nmol/l
—
0
0
682
6186
1.79
7.00
5.6
4.4
6.01
5.76
mmol/l
3.41
640
5738
55
256
2.24
6.86
1.9
1.6
8.27
8.36
u/l
0.02
50
200
34
126
2.78
6.85
1.1
1.1
—
—
—
0
0
103
603
1.82
6.78
4.3
2.5
27.49
35.02
u/l
1.95
92
514
24
73
3.36
6.74
2.0
1.6
19.23
28.68
ng/l
0.95
24
73
168
1131
1.62
6.64
5.1
3.7
144.21
420.63
ng/l
1.53
120
804
21
59
3.63
6.63
3.6
2.0
90.84
90.32
%
0.22
21
59
17
41
4.22
6.57
4.6
2.0
—
—
—
0
0
215
1546
1.54
6.37
3.1
2.2
—
—
—
0
0
37
149
2.56
6.36
6.3
8.9
1.46
1.23
mmol/l
0.71
29
125
29
103
2.89
6.32
8.6
5.6
372.13
371.91
umol/l
0.00
24
92
41
175
2.42
6.24
1.2
1.4
3.55
3.67
mmol/l
0.48
36
165
19
52
3.72
6.23
1.2
1.0
—
—
—
0
0
203
1452
1.54
6.13
1.9
1.7
—
—
—
0
0
18
48
3.81
6.11
1.2
2.4
—
—
—
0
0
15
25
6.10
6.02
2.3
5.8
56.11
111.65
umol/l
—
9
17
20
59
3.45
5.89
3.7
3.3
1331.00
1235.11
e6/l
0.10
15
53
739
6945
2.14
5.86
24.2
11.5
—
—
—
0
0
32
125
2.63
5.86
1.3
1.6
0.60
0.65
g/l
0.09
24
97
68
365
1.95
5.86
3.3
3.0
132.05
172.07
ng/l
0.72
60
337
17
35
4.94
5.76
1.9
1.5
21.23
28.18
%
0.34
12
22
23
76
3.09
5.69
1.9
1.8
0.79
0.86
%
0.25
18
47
81
466
1.82
5.65
1.5
1.2
—
—
—
0
0
12
16
7.60
5.64
1.2
1.6
13.70
5.89
pmol/l
—
5
7
11
13
8.56
5.57
1.1
1.0
—
—
—
0
0
45
211
2.20
5.55
2.6
3.6
454.72
278.46
mg/l
0.57
29
92
13
21
6.28
5.40
33.2
35.4
123.50
117.81
ug/l
—
8
16
39
175
2.29
5.35
1.2
1.5
135.73
168.51
e6/l
0.12
26
133
36
156
2.37
5.34
1.2
1.5
—
—
—
0
0
239
1813
1.46
5.31
2.2
2.1
—
—
—
0
0
12
18
6.75
5.27
1.6
1.8
89.18
71.50
nmol/24h
0.33
12
18
60
323
1.93
5.14
7.8
2.7
—
—
—
0
0
38
172
2.27
5.11
1.2
1.5
28.91
15.16
e6/l
0.35
22
128
29
118
2.51
4.93
10.8
3.8
—
—
—
0
0
42
202
2.14
4.89
2.2
2.0
8.52
4.41
iu/l
0.33
20
86
50
259
1.99
4.80
3.1
2.3
20.33
20.89
s
0.44
42
236
31
132
2.40
4.79
12.9
3.4
67.31
62.12
%
0.63
31
132
21
73
2.93
4.79
1.8
1.7
31.81
32.66
pg
0.36
21
73
254
1980
1.42
4.79
4.5
2.8
0.00
0.07
—
7
30
43
211
2.10
4.77
1.2
1.2
—
—
—
0
0
24
91
2.69
4.69
1.6
1.8
—
—
—
0
0
57
312
1.89
4.67
2.4
2.2
0.00
0.01
estimate
0.50
19
106
700
6540
1.66
4.63
5.9
5.1
2.70
2.78
mmol/l
1.34
658
6156
27
110
2.51
4.59
2.2
2.6
100.23
103.42
ug/min
0.02
17
63
764
7345
2.66
4.58
43.1
20.2
257.62
254.49
e9/l
0.61
756
7236
764
7349
2.63
4.50
43.0
20.1
4.41
4.52
e12/l
7.71
756
7219
101
661
1.61
4.42
1.2
1.2
—
—
—
0
0
764
7353
2.61
4.42
43.1
20.2
7.02
6.64
e9/l
5.76
755
7221
66
388
1.77
4.32
1.4
1.2
—
—
—
0
0
87
553
1.64
4.29
2.9
4.2
3.54
27.20
ug/l
1.01
67
463
21
78
2.74
4.28
1.1
1.5
—
—
—
0
0
689
6436
1.59
4.28
5.3
4.5
1.38
1.49
mmol/l
9.29
646
6047
691
6460
1.59
4.26
5.5
4.6
4.55
4.71
mmol/l
3.37
648
6093
13
29
4.54
4.26
1.2
1.2
132.69
158.51
mmol/24h
0.50
13
29
39
193
2.07
4.25
1.2
2.1
10.82
10.55
g/l
0.14
34
179
37
706
0.50
4.22
1.6
1.7
3.20
3.48
mmol/l
0.88
27
515
15
39
3.90
4.21
2.3
2.7
1049.67
1124.62
mg
0.05
15
39
658
6092
1.50
4.19
4.7
3.9
1.43
1.23
mmol/l
7.22
616
5683
9
13
6.99
4.17
2.4
1.2
—
—
—
0
0
14
42
3.38
4.06
5.9
2.9
278.83
18.35
mg/l
0.89
14
28
15
48
3.17
3.94
1.1
1.0
—
—
—
0
0
14
43
3.30
3.92
1.1
1.3
56016.37
35784.41
e6/l
—
8
22
230
2845
0.73
3.90
3.1
2.8
—
—
—
0
0
36
179
2.06
3.90
1.7
1.2
41.36
42.48
u/ml
—
8
20
16
54
3.00
3.86
1.6
1.0
—
—
—
0
0
55
317
1.79
3.86
1.3
1.4
—
—
—
0
0
257
2068
1.36
3.86
5.6
3.1
0.00
0.05
estimate
0.72
96
624
14
38
3.73
3.81
7.1
2.4
1.07
0.79
index
0.71
14
38
71
444
1.66
3.74
1.7
1.5
16.58
23.14
iu/l
1.11
57
376
50
834
0.57
3.65
1.3
1.3
—
—
—
0
0
80
520
1.60
3.62
3.3
2.3
6.13
6.18
ph
0.20
55
338
50
287
1.79
3.58
2.6
2.3
—
—
—
0
0
41
221
1.90
3.57
1.7
1.2
1.74
2.93
u/ml
—
5
23
14
46
3.08
3.54
2.7
1.2
—
—
—
0
0
14
46
3.08
3.54
4.4
3.2
790.50
548.97
e6/l
—
8
37
13
36
3.65
3.50
2.8
3.9
1410.92
762.00
u/ml
0.59
13
36
8
13
6.20
3.50
1.1
1.1
—
—
—
0
0
48
275
1.79
3.46
1.3
1.3
—
—
—
0
0
16
58
2.80
3.44
1.8
1.7
67.00
57.74
%
0.45
11
43
22
94
2.38
3.43
1.1
1.1
13.36
103.41
iu/ml
—
5
22
15
53
2.87
3.37
4.4
3.3
48.35
40.44
%
1.23
15
53
33
169
1.99
3.33
1.5
1.4
—
—
—
0
0
25
115
2.21
3.32
4.2
3.4
4.26
4.13
e9/l
0.08
25
115
25
115
2.21
3.32
1.4
1.1
—
—
—
0
0
106
749
1.48
3.30
1.5
1.3
—
—
—
0
0
13
43
3.06
3.26
1.0
1.1
1640.08
1561.12
miu/ml
0.08
13
43
85
576
1.53
3.23
1.4
1.2
390.40
143.52
u/ml
0.72
28
243
7
11
6.41
3.19
1.9
1.3
3.82
9.88
mmol/l
—
7
11
31
159
1.99
3.13
1.3
1.4
145.00
149.32
au/ml
—
7
55
40
224
1.83
3.12
1.5
1.2
—
—
—
0
0
21
92
2.32
3.12
2.2
1.5
—
—
—
0
0
21
92
2.32
3.12
2.2
1.5
—
—
—
0
0
21
92
2.32
3.12
2.2
1.5
—
—
—
0
0
21
92
2.32
3.12
2.2
1.5
—
—
—
0
0
14
50
2.83
3.10
1.2
1.3
816.89
2739.18
e6/l
—
9
33
34
182
1.91
3.05
1.2
1.4
221.38
234.84
u/ml
0.14
24
109
31
161
1.96
3.03
4.9
2.7
3.45
2.46
index
0.36
22
86
5
5
10.05
2.98
1.0
1.0
—
—
—
0
0
13
46
2.86
2.93
4.7
3.3
215.63
196.15
e6/l
—
8
40
13
46
2.86
2.93
1.2
1.1
—
—
—
0
0
11
32
3.47
2.90
1.2
1.6
—
—
—
0
0
59
379
1.60
2.84
4.7
1.9
—
—
—
0
0
314
2692
1.28
2.81
2.0
1.9
1.51
1.31
mmol/l
3.37
271
2317
67
447
1.55
2.76
4.8
2.0
—
—
—
0
0
19
85
2.27
2.72
1.2
1.7
—
—
—
0
0
8
19
4.24
2.68
3.4
2.5
0.60
0.62
mmol/l
—
8
19
52
329
1.62
2.68
1.1
1.1
—
—
—
0
0
36
208
1.77
2.58
1.4
1.2
—
—
—
0
0
8
20
4.03
2.57
1.6
2.6
20.63
29.10
%
—
8
20
5
7
7.18
2.55
1.4
1.0
2.14
1.56
nmol/l
—
5
7
13
50
2.63
2.54
1.2
1.1
—
—
—
0
0
29
158
1.87
2.51
5.0
3.1
56.55
58.07
%
0.38
29
158
7
16
4.40
2.48
2.1
3.5
—
—
—
0
0
12
45
2.69
2.46
1.2
1.5
—
—
—
0
0
14
57
2.48
2.46
1.1
1.1
—
—
—
0
0
13
51
2.58
2.45
1.2
1.1
—
—
—
0
0
6
12
5.03
2.40
2.8
1.7
—
—
—
0
0
69
480
1.48
2.36
4.7
1.9
—
—
—
0
0
69
482
1.47
2.32
4.7
1.9
—
—
—
0
0
7
18
3.91
2.25
3.6
2.4
—
—
—
0
0
69
486
1.46
2.23
4.7
1.9
—
—
—
0
0
9
30
3.02
2.15
2.8
3.6
15.92
16.24
%
—
9
30
11
42
2.64
2.15
1.1
1.3
—
—
—
0
0
17
81
2.12
2.14
2.1
4.0
—
—
—
0
0
18
88
2.07
2.12
1.1
1.1
—
—
—
0
0
9
31
2.92
2.07
2.1
1.7
—
3280.00
—
0
5
9
31
2.92
2.07
1.3
1.2
—
—
—
0
0
19
96
2.00
2.07
1.3
1.2
—
—
—
0
0
13
56
2.34
2.05
1.5
2.2
4.13
4.03
mmol/l
0.26
13
56
13
56
2.34
2.05
1.5
2.2
106.77
105.82
mmol/l
0.30
13
56
67
478
1.44
2.04
3.7
1.8
—
—
—
0
0
6
15
4.02
2.04
1.3
1.1
—
—
—
0
0
31
185
1.70
2.04
1.6
2.7
—
—
—
0
0
104
801
1.34
2.02
1.8
1.5
—
—
—
0
0
8
26
3.10
2.01
1.0
1.1
—
—
—
0
0
8
26
3.10
2.01
1.0
1.1
—
—
—
0
0
8
26
3.10
2.01
1.0
1.1
—
—
—
0
0
7
21
3.35
1.97
3.3
3.2
—
35.00
—
0
5
6
16
3.77
1.93
1.0
1.0
—
—
—
0
0
13
58
2.26
1.91
22.2
4.7
11.01
11.23
%
0.09
13
58
7
22
3.20
1.88
1.9
1.2
—
—
—
0
0
9
34
2.67
1.87
2.6
3.4
12.66
7.51
mmol/l
—
9
34
6
17
3.55
1.84
1.7
2.5
41.13
42.26
g/l
—
6
17
18
95
1.92
1.76
1.2
1.3
—
—
—
0
0
37
550
0.66
1.74
1.4
1.6
1051.04
1051.71
mu/l
0.00
30
468
5
13
3.86
1.71
2.8
1.5
611.00
10465.40
e6/l
—
5
5
34
219
1.58
1.70
2.1
3.2
248.09
1581.01
u/ml
0.95
27
192
42
286
1.50
1.65
2.1
1.8
—
—
—
0
0
44
303
1.48
1.64
2.6
1.8
—
—
—
0
0
13
250
0.51
1.63
1.7
1.5
—
—
—
0
0
12
56
2.16
1.61
1.6
2.2
1.22
1.21
mmol/l
0.14
12
56
24
144
1.69
1.59
1.9
1.3
3.00
3.12
ug/l
0.05
19
130
6
20
3.01
1.58
2.7
1.7
—
—
—
0
0
13
247
0.52
1.58
1.7
1.4
—
—
—
0
0
11
51
2.17
1.51
1.1
1.1
342.17
425.67
nmol/l
—
6
45
39
272
1.46
1.40
1.6
1.7
16.33
8.46
u/ml
—
9
71
46
333
1.41
1.36
1.3
1.3
285.48
259.54
miu/ml
0.12
14
167
9
44
2.06
1.27
1.2
1.8
—
—
—
0
0
19
116
1.65
1.22
1.4
1.3
4.30
6.11
u/ml
—
10
57
8
37
2.17
1.21
1.4
1.8
3.13
6.90
u/field
—
8
27
29
197
1.49
1.21
13.0
8.8
—
—
—
0
0
71
563
1.29
1.19
5.2
3.7
—
—
—
0
0
5
20
2.51
1.15
3.2
1.4
—
—
—
0
0
17
104
1.65
1.10
1.7
1.4
—
—
—
0
0
13
74
1.77
1.07
2.2
3.2
—
—
—
0
0
13
75
1.75
1.03
1.1
1.1
—
—
—
0
0
287
2632
1.14
1.03
2.1
2.1
—
—
—
0
0
9
48
1.88
1.00
1.1
1.1
—
—
—
0
0
5
23
2.18
0.98
1.0
1.3
—
—
—
0
0
5
23
2.18
0.98
5.2
1.3
—
—
—
0
0
5
23
2.18
0.98
1.2
1.2
—
—
—
0
0
5
23
2.18
0.98
2.4
1.8
13.20
15.77
umol/l
—
5
23
5
23
2.18
0.98
1.0
1.8
—
—
—
0
0
7
36
1.95
0.97
1.7
1.4
5.55
6.02
mmol/l
—
7
36
71
861
0.81
0.96
3.1
3.0
0.74
0.73
ug/l
0.04
50
517
10
55
1.83
0.92
3.9
4.5
—
—
—
0
0
11
63
1.76
0.90
1.5
1.3
—
—
—
0
0
6
30
2.01
0.87
4.2
2.7
—
—
—
0
0
228
2082
1.13
0.86
1.5
1.6
—
—
—
0
0
12
72
1.68
0.85
2.2
4.8
109.34
48.90
u/ml
—
5
26
10
164
0.60
0.81
1.0
1.1
—
—
—
0
0
10
164
0.60
0.81
1.0
1.1
—
—
—
0
0
15
98
1.54
0.79
2.1
1.6
—
—
—
0
0
5
26
1.93
0.70
4.6
3.0
—
—
—
0
0
5
26
1.93
0.70
2.4
3.1
—
—
—
0
0
24
319
0.74
0.70
1.0
1.1
1.55
1.55
g/l
0.01
24
319
14
93
1.51
0.70
1.2
1.3
—
—
—
0
0
13
85
1.54
0.69
2.8
2.3
—
—
—
0
0
27
207
1.32
0.64
1.1
1.1
4.27
3.64
u/ml
0.08
19
114
23
176
1.32
0.57
1.1
1.1
10.05
5.47
u/ml
0.85
16
108
92
818
1.14
0.55
1.3
1.3
—
—
—
0
0
96
1073
0.88
0.55
1.8
1.5
—
—
—
0
0
43
359
1.21
0.54
1.1
1.1
—
—
—
0
0
10
66
1.52
0.52
1.1
1.2
—
—
—
0
0
22
171
1.29
0.50
1.1
1.1
3.13
1.39
u/ml
0.41
13
82
17
127
1.35
0.50
1.2
1.1
—
—
—
0
0
14
101
1.39
0.49
2.4
2.6
—
17.99
—
0
8
16
210
0.76
0.46
1.3
1.1
—
—
—
0
0
27
326
0.82
0.41
1.5
1.1
0.85
0.90
g/l
0.66
27
326
0
17
0.00
0.40
0.0
1.5
—
—
—
0
0
57
503
1.14
0.40
1.7
1.4
—
—
—
0
0
6
45
1.34
0.34
1.8
2.2
—
—
—
0
0
22
182
1.21
0.33
1.0
1.1
4.76
1.57
u/ml
0.49
14
95
6
46
1.31
0.33
1.2
1.2
—
—
—
0
0
17
138
1.24
0.30
1.0
1.1
8.55
7.00
u/ml
—
9
57
86
795
1.09
0.30
2.0
1.7
—
—
—
0
0
8
62
1.29
0.28
1.1
1.2
—
—
—
0
0
11
139
0.79
0.27
1.8
1.9
—
—
—
0
0
14
113
1.24
0.26
1.5
1.2
—
—
—
0
0
148
1412
1.06
0.24
4.0
5.0
1.66
2.41
ug/l
1.46
133
1281
18
152
1.19
0.24
1.0
1.1
0.49
3.88
u/ml
2.98
12
76
18
154
1.17
0.21
1.2
1.1
—
—
—
0
0
15
177
0.84
0.21
1.2
1.3
—
—
—
0
0
5
43
1.16
0.21
1.4
1.2
15.40
8.30
mm/h
—
5
43
72
760
0.94
0.16
1.7
1.5
—
—
—
0
0
5
46
1.09
0.09
1.4
1.4
87.20
72.85
umol/l
—
5
46
5
48
1.04
0.09
1.0
1.5
24.34
31.95
nmol/l
—
5
40
41
430
0.95
0.08
1.5
1.7
—
—
—
0
0
5
62
0.81
0.08
1.6
1.2
—
—
—
0
0
115
1127
1.02
0.06
1.8
1.9
—
—
—
0
0
14
129
1.09
0.05
1.0
1.1
0.07
0.44
u/ml
—
7
42
12
127
0.94
0.01
3.3
3.8
23.10
30.18
mg/l
—
7
87
0
5
0.00
0.00
0.0
1.4
—
230.20
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
1.71
—
0
9
0
9
0.00
0.00
0.0
2.9
—
7.34
—
0
9
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
58
0.86
-0.00
2.2
2.4
—
—
—
0
0
8
86
0.93
-0.00
2.8
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.0
—
0.13
—
0
6
6
65
0.92
-0.00
1.2
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint E4_VIT_D_DEF and mortality.

Females

Parameter HR [95% CI] p-value
E4_VIT_D_DEF 1.849 [1.5, 2.29] < 0.001
Birth year 0.996 [0.99, 1.0] 0.396

During the follow-up period (1.1.1998 — 31.12.2019), 343 out of 2160 females with E4_VIT_D_DEF died.

Males

Parameter HR [95% CI] p-value
E4_VIT_D_DEF 2.763 [1.99, 3.84] < 0.001
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 271 out of 1341 males with E4_VIT_D_DEF died.

Mortality risk

Mortality risk for people of age

years, who have E4_VIT_D_DEF.

N-year risk Females Males
1 0.172% 0.546%
5 1.005% 3.188%
10 2.601% 7.561%
15 5.141% 14.755%
20 9.109% 24.402%

Relationships between endpoints

Index endpoint: E4_VIT_D_DEF – Vitamin D deficiency

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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