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This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Other effects of reduced temperature

ST19_OTHER_EFFEC_REDUCED_TEMPE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 T69
  • Cause of death: ICD-10 T69

2 out of 7 registries used, show all original rules.

91

4. Check minimum number of events

None

91

5. Include endpoints

None

91

6. Filter based on genotype QC (FinnGen only)

88

Control definitions (FinnGen only)

Control exclude
ST19_OTHER_UNSPE_EFFEC_EXTER_CAUSES

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
T6[6-9]|T7[0-8]
Name in latin
Alii effectus caloris deminuti

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 88 52 36
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 47.41 43.47 53.11

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
89
Matched controls
890
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
T69.1
ICD-10 Finland
Chilblains
689.8
43.0
39
*
T69.8
ICD-10 Finland
Other specified effects of reduced temperature
+∞
28.7
26
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
11.8
21.8
26
30
X31
ICD-10 Finland
Exposure to excessive natural cold
+∞
17.2
16
*
T69.9
ICD-10 Finland
Effect of reduced temperature, unspecified
+∞
15.0
14
*
I73.0
ICD-10 Finland
Raynaud syndrome
75.1
11.9
13
*
T69.0
ICD-10 Finland
Immersion hand and foot
+∞
10.6
10
*
E0000UV, ,
ATC
3.7
8.5
55
269
D07AC01
ATC
betamethasone; topical
3.1
6.5
44
212
C08CA02
ATC
felodipine; oral
6.3
6.2
16
30
X57
ICD-10 Finland
Unspecified privation
16.5
6.0
9
6

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
27
35
10.64
20.78
2.4
1.8
5.64
8.25
iu/ml
—
7
8
40
114
5.56
14.16
2.1
1.4
612.31
574.40
titre
0.03
13
25
51
244
3.55
8.02
9.1
6.2
—
—
—
0
0
31
108
3.87
7.90
1.7
1.5
—
—
—
0
0
12
9
15.16
7.63
1.2
1.1
—
—
—
0
0
19
49
4.66
7.14
1.4
2.1
—
—
—
0
0
15
21
8.35
7.06
1.3
1.1
—
—
—
0
0
66
400
3.52
6.58
8.4
6.5
0.59
0.57
e9/l
0.32
60
352
67
411
3.55
6.53
8.1
6.5
1.76
1.80
e9/l
0.18
62
373
66
403
3.47
6.44
8.3
6.5
0.05
0.04
e9/l
0.71
60
352
67
415
3.49
6.34
10.0
6.7
0.18
0.18
e9/l
0.02
60
370
35
154
3.10
5.97
1.7
1.3
17.16
22.58
iu/ml
0.30
13
55
70
458
3.48
5.79
10.2
10.6
4.01
4.09
e9/l
0.14
64
401
12
18
7.52
5.47
1.3
1.2
—
—
—
0
0
20
67
3.56
5.23
1.4
1.4
—
—
—
0
0
14
28
5.73
5.21
1.4
1.1
—
—
—
0
0
34
160
2.82
5.01
1.9
1.8
—
—
—
0
0
16
59
3.09
3.55
1.7
2.3
67.38
66.59
g/l
0.21
16
53
27
136
2.41
3.31
1.6
1.4
27.34
11.04
u/ml
—
8
59
21
96
2.55
3.14
3.0
1.7
—
—
—
0
0
7
12
6.22
3.08
1.0
1.2
—
—
—
0
0
35
203
2.19
3.07
2.2
2.0
—
—
—
0
0
47
314
2.05
2.79
2.1
2.0
98.65
95.78
pmol/l
0.15
25
149
6
10
6.34
2.74
1.0
1.5
—
—
—
0
0
6
10
6.34
2.74
1.3
1.8
—
—
—
0
0
52
363
2.04
2.71
3.0
3.2
—
—
estimate
—
0
0
6
11
5.76
2.58
1.0
1.5
—
—
—
0
0
5
7
7.48
2.58
3.6
1.9
—
—
—
0
0
32
190
2.07
2.58
1.6
1.4
2.37
2.18
g/l
0.35
24
115
67
519
2.18
2.57
5.1
4.3
—
69.38
—
0
8
18
84
2.43
2.56
1.2
1.8
—
—
—
0
0
33
201
2.02
2.47
5.8
4.8
—
—
—
0
0
48
336
1.93
2.38
4.2
3.6
6.40
6.21
ph
0.49
25
186
34
212
1.98
2.37
1.8
1.6
19.62
19.44
nmol/l
0.03
27
175
47
328
1.92
2.34
7.1
8.5
1.21
1.21
mmol/l
0.04
41
298
43
293
1.90
2.29
4.4
3.9
18.27
72.17
e6/l
0.82
30
206
48
341
1.88
2.23
15.0
11.7
0.00
0.00
e9/l
-0.00
40
281
36
236
1.88
2.12
2.3
2.7
—
—
—
0
0
21
116
2.06
2.00
2.6
2.4
—
—
—
0
0
7
23
3.21
1.84
1.3
1.2
—
—
—
0
0
48
361
1.72
1.70
7.8
10.0
1.21
1.21
mmol/l
0.00
39
312
31
206
1.77
1.70
1.5
1.2
0.55
1.94
u/ml
0.84
11
46
37
260
1.72
1.67
3.4
3.1
44.23
37.33
e6/l
0.07
27
198
80
710
2.25
1.63
5.0
5.4
1.83
1.87
mu/l
0.14
73
651
10
44
2.43
1.62
4.5
15.5
—
—
—
0
0
8
33
2.56
1.58
6.5
19.9
1.04
0.87
%
—
8
28
19
111
1.90
1.54
1.2
1.6
—
—
—
0
0
10
45
2.38
1.53
3.5
6.1
24.26
24.70
mmol/l
—
10
45
32
222
1.69
1.48
2.9
3.0
0.33
0.21
e6/l
0.30
22
162
26
171
1.74
1.45
1.8
1.8
0.76
1.10
mg/l
0.52
21
132
55
443
1.63
1.40
5.4
3.8
0.00
0.00
estimate
-0.00
11
92
18
107
1.86
1.39
2.1
2.2
33.37
107.03
ug/g
2.50
13
81
15
84
1.94
1.37
4.5
14.6
7.44
7.42
ph
—
10
53
15
85
1.92
1.33
1.6
1.9
—
—
—
0
0
9
44
2.16
1.31
4.1
2.6
195.00
123.44
ng/l
—
9
39
8
35
2.41
1.31
6.6
19.0
2.25
1.33
%
—
8
30
5
18
2.88
1.30
3.8
4.1
72.84
55.68
%
—
5
18
54
438
1.59
1.29
5.4
3.8
0.00
0.00
estimate
-0.00
11
91
30
212
1.63
1.27
3.2
2.8
—
—
estimate
—
0
0
10
49
2.17
1.27
2.7
1.3
—
—
—
0
0
10
49
2.17
1.27
2.7
1.3
—
—
—
0
0
55
449
1.59
1.27
5.3
3.8
0.00
0.00
estimate
-0.00
11
88
12
64
2.01
1.25
4.3
4.2
79.29
79.85
e9/l
—
7
47
10
50
2.13
1.22
2.8
1.3
—
—
—
0
0
10
50
2.13
1.22
2.7
1.3
—
—
—
0
0
10
50
2.13
1.22
5.2
3.2
—
—
—
0
0
21
137
1.70
1.20
3.4
3.6
49.13
84.05
ng/l
0.32
15
102
7
30
2.44
1.15
3.0
2.2
—
—
—
0
0
33
247
1.53
1.08
5.3
3.6
—
—
—
0
0
5
22
2.35
1.04
1.0
2.2
9.90
11.55
mg/l
—
5
22
9
49
1.93
1.02
7.0
3.1
23.89
23.70
mmol/l
—
9
49
37
292
1.46
0.92
4.4
3.4
27.13
32.45
ng/l
0.17
28
185
6
29
2.14
0.91
2.0
2.7
1.15
1.58
mg/l
—
6
24
29
219
1.48
0.89
5.6
6.5
—
—
—
0
0
8
44
1.90
0.88
1.3
1.1
—
—
—
0
0
8
47
1.77
0.83
1.0
1.1
—
—
—
0
0
8
48
1.73
0.81
3.1
1.3
—
—
—
0
0
67
599
1.48
0.81
4.1
4.4
14.72
14.80
pmol/l
0.09
62
545
24
179
1.47
0.78
3.8
2.4
2.70
4.84
e6/l
1.27
24
160
6
34
1.82
0.78
3.2
1.6
—
0.00
estimate
—
0
10
5
23
2.24
0.77
3.2
2.3
26.60
24.58
mmol/l
—
5
23
20
144
1.50
0.77
3.9
2.9
533.23
501.41
mosm/kgh2o
0.31
20
122
7
39
1.86
0.74
1.0
1.1
—
—
—
0
0
7
40
1.81
0.73
2.1
12.5
22.76
25.04
mmol/l
—
7
40
12
77
1.65
0.73
1.2
1.5
—
—
—
0
0
11
69
1.68
0.72
6.6
9.6
—
—
—
0
0
24
182
1.44
0.71
6.5
4.4
—
—
—
0
0
5
29
1.77
0.65
2.6
1.4
—
—
—
0
0
8
51
1.62
0.62
3.3
2.7
1.71
1.44
%
—
8
51
8
51
1.62
0.62
3.3
2.7
0.49
0.65
%
—
8
51
36
301
1.33
0.59
2.2
1.9
—
—
—
0
0
0
23
0.00
0.59
0.0
1.3
—
—
—
0
0
30
246
1.33
0.56
5.9
3.7
0.00
0.02
estimate
0.49
11
85
6
39
1.58
0.54
2.5
1.3
—
—
—
0
0
14
102
1.44
0.51
1.4
1.2
—
—
—
0
0
10
69
1.51
0.46
1.5
1.1
—
—
—
0
0
10
70
1.48
0.44
6.8
3.6
—
—
—
0
0
27
226
1.28
0.43
5.8
4.4
7.40
7.40
ph
0.02
17
154
8
60
1.37
0.41
2.4
5.1
1.23
1.22
mmol/l
—
8
50
0
17
0.00
0.41
0.0
1.7
—
9.41
—
0
17
0
18
0.00
0.40
0.0
1.9
—
2.19
—
0
10
0
18
0.00
0.40
0.0
4.3
—
37.36
—
0
10
5
75
0.65
0.37
4.4
2.4
12.90
15.25
nmol/l
—
5
70
28
240
1.24
0.36
1.6
1.5
—
—
—
0
0
39
347
1.22
0.36
5.5
3.6
0.00
0.04
estimate
0.49
11
77
21
248
0.80
0.34
5.0
2.9
—
—
—
0
0
10
75
1.38
0.32
1.5
1.3
—
—
—
0
0
15
122
1.28
0.29
1.9
1.7
—
—
—
0
0
26
231
1.18
0.23
6.2
4.5
28.98
13.29
mg/mmol
0.27
18
146
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
3.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
3.0
—
21.38
—
0
12
75
726
1.21
0.20
5.1
4.7
5.55
5.87
mmol/l
2.29
70
665
0
14
0.00
0.20
0.0
4.1
—
2.84
—
0
14
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
23
205
1.16
0.19
5.5
3.6
1.01
1.02
kg/l
0.94
15
131
25
228
1.13
0.15
5.6
3.7
128.96
70.65
mg/l
0.29
17
151
11
95
1.18
0.12
1.1
1.2
—
—
—
0
0
12
105
1.17
0.12
4.5
7.5
104.50
104.15
mmol/l
0.10
12
105
5
48
1.04
0.09
2.6
11.5
90.40
93.63
%
—
5
48
5
48
1.04
0.09
1.2
1.3
—
—
—
0
0
31
302
1.04
0.02
2.1
3.1
—
—
—
0
0
26
262
0.99
0.00
5.9
3.0
0.00
0.01
estimate
0.49
11
75
0
7
0.00
0.00
0.0
1.1
—
128.95
—
0
7
8
88
0.90
0.00
1.7
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
3.9
—
—
—
0
0
0
7
0.00
0.00
0.0
9.4
—
0.64
—
0
7
0
7
0.00
0.00
0.0
1.0
—
1806.00
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
0.59
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
16.58
—
0
5
0
5
0.00
-0.00
0.0
2.6
—
6.08
—
0
5
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
49
1.02
-0.00
2.6
10.7
1.60
1.44
%
—
5
49
6
67
0.89
-0.00
1.3
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
77.00
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
4.04
—
0
5

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: ST19_OTHER_EFFEC_REDUCED_TEMPE – Other effects of reduced temperature

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).