blood coagulation disease: A condition in which there is a deviation from or interruption of the normal coagulation properties of the blood.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
196 |
4. Check minimum number of eventsNone |
196 |
5. Include endpoints |
1015 |
6. Filter based on genotype QC (FinnGen only) |
914 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF2
Chronic Coagulation defects
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6363 | 4116 | 2218 |
| Only index persons | 5866 | 3942 | 1924 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.12 | 0.06 |
| Only index persons | 0.12 | 0.14 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 29.42 | 33.02 | 22.61 |
| Only index persons | 29.70 | 32.84 | 23.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 914 | 690 | 224 |
| Unadjusted period prevalence (%) | 0.21 | 0.24 | 0.10 |
| Median age at first event (years) | 38.42 | 36.29 | 44.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 953
- Matched controls
- 9530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D68.8
ICD-10 Finland
Other specified coagulation defects
67.1
307.7
206
39
D68.0
ICD-10 Finland
Von Willebrand disease
+∞
307.7
489
*
D68.2
ICD-10 Finland
Hereditary deficiency of other clotting factors
2821.8
307.7
349
*
B02AA02
ATC
tranexamic acid; systemic
8.6
247.4
501
1093
126
Kela drug reimbursment
Chronic coagulation defects
+∞
198.0
183
*
D68.9
ICD-10 Finland
Coagulation defect, unspecified
101.7
177.4
92
10
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
36.1
176.1
112
35
D66
ICD-10 Finland
Hereditary factor VIII deficiency
+∞
96.5
91
*
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
36.3
71.5
45
13
B01AA03
ATC
warfarin; systemic
4.2
63.6
202
577
B01AB04
ATC
dalteparin; parenteral
5.4
47.8
100
202
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
5.1
45.4
101
215
N02AX02
ATC
tramadol; systemic, rectal
2.5
42.0
474
2696
B02BD02
ATC
coagulation factor VIII; parenteral
+∞
40.9
39
*
2864A
ICD-9 Finland
Coagulation defects, von Willebrand's disease
+∞
39.9
38
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
4.4
39.8
108
270
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
5.6
39.2
78
150
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
7.4
37.2
55
78
B01AB05
ATC
enoxaparin; parenteral
2.4
35.5
345
1803
R79.8
ICD-10 Finland
Other specified abnormal findings of blood chemistry
13.8
34.1
32
24
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
6.4
32.1
54
88
28630
ICD-8 Finland
Coagulation defects, Vascular haemophilia
+∞
30.4
29
*
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
2.8
29.7
171
687
EBA10
NOMESCO Finland
Operative extraction of tooth
2.5
28.6
210
952
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
28.2
447
2794
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.1
26.2
463
2990
2860A
ICD-9 Finland
Coagulation defects, Congenital factor VIII disorder
+∞
26.2
25
*
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
4.2
25.4
70
176
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.7
24.6
145
587
M01AE01
ATC
ibuprofen; systemic, rectal
0.5
24.5
681
8065
R04.0
ICD-10 Finland
Epistaxis
3.4
24.3
95
304
B02BX06
ATC
emicizumab; parenteral
+∞
24.1
23
*
M362, D66,
ICD-10 Finland
+∞
24.1
23
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.4
24.0
92
291
28600
ICD-8 Finland
Coagulation defects, Haemophilia
+∞
23.0
22
*
1520, ,
Kela drug reimbursment
+∞
22.0
21
*
3047, ,
Kela drug reimbursment
+∞
22.0
21
*
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
2.4
21.7
166
760
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
21.4
159
718
ZX120
NOMESCO Finland
Intravenous
2.8
20.6
116
457
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.7
20.5
48
106
D67
ICD-10 Finland
Hereditary factor IX deficiency
+∞
19.9
19
*
2BD06, ,
NOMESCO Finland
+∞
19.9
19
*
R42
ICD-10 Finland
Dizziness and giddiness
2.1
19.6
233
1274
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.1
19.5
86
296
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
19.4
285
1683
M25.0
ICD-10 Finland
Haemarthrosis
8.5
19.3
25
30
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
18.9
267
1554
N02AJ06
ATC
codeine and paracetamol; systemic
1.9
18.8
446
3071
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
18.1
349
2247
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.6
17.5
113
476
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
17.3
402
2731
ZXE00
NOMESCO Finland
One hour or less
1.8
16.9
402
2747
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
16.1
217
1233
D68.1
ICD-10 Finland
Hereditary factor XI deficiency
+∞
15.7
15
*
D69.1
ICD-10 Finland
Qualitative platelet defects
86.5
15.6
17
*
N02BE01
ATC
paracetamol; systemic, rectal
2.4
15.4
857
7505
Z31.5
ICD-10 Finland
Genetic counselling
2.6
15.3
93
380
I80.29
ICD-10 Finland
Phlebitis and thrombophlebitis of other deep vessels of lower extremities
3.7
15.2
48
133
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
15.2
409
2872
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.8
15.1
335
2223
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
14.9
300
1935
M36.2
ICD-10 Finland
Haemophilic arthropathy
+∞
14.6
14
*
D68.4
ICD-10 Finland
Acquired coagulation factor deficiency
152.2
14.5
15
*
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.6
14.5
89
365
O28.0
ICD-10 Finland
Abnormal haematological finding on antenatal screening of mother
36.6
14.5
18
5
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.1
14.5
158
830
H02AB06
ATC
prednisolone; systemic
1.7
14.2
451
3294
M79.6
ICD-10 Finland
Pain in limb
1.7
14.2
450
3285
TLC00
NOMESCO Finland
Insertion of intrauterine device
2.3
13.8
108
496
N03AX16
ATC
[U] pregabalin
1.9
13.7
219
1309
AA1AD
NOMESCO Finland
CT of head and brain
1.8
13.6
237
1455
UJF32
NOMESCO Finland
Coloscopy
1.9
13.6
226
1368
Z3231
NOMESCO Finland
Registered nurse
1.8
13.5
269
1722
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
13.4
426
3100
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
13.3
198
1156
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
13.0
352
2448
R06.0
ICD-10 Finland
Dyspnoea
1.8
12.9
254
1617
194
Kela drug reimbursment
Blood coagulation factor VIII and von Willebrand factor for the treatment of von Willebrand disease
+∞
12.5
12
*
B18.2
ICD-10 Finland
Chronic viral hepatitis C
5.1
12.5
26
52
K01.0
ICD-10 Finland
Embedded teeth
3.9
12.4
36
94
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
12.4
146
786
R4110
NOMESCO Finland
Physiotherapy
1.7
12.4
263
1708
J01FF01
ATC
clindamycin; systemic
1.7
12.3
261
1692
G43.9
ICD-10 Finland
Migraine, unspecified
2.3
12.3
103
486
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
5.2
12.3
25
49
K94
ICPC
Phlebitis/thrombophlebitis
5.0
12.2
26
53
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
12.2
286
1908
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
12.0
226
1414
R51.80
ICD-10 Finland
Headache
1.8
11.9
198
1194
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.5
11.9
75
312
J01DA01
ATC
[U] cefalexin
1.6
11.6
581
4669
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.3
11.6
93
431
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.7
11.6
260
1710
I82.88
ICD-10 Finland
Embolism and thrombosis of other specified veins
4.6
11.5
27
60
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
11.4
198
1208
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
11.3
267
1778
R23.3
ICD-10 Finland
Spontaneous ecchymoses
3.9
11.3
33
87
J01DB01
ATC
cefalexin; oral
1.9
11.1
801
7044
K08.3
ICD-10 Finland
Retained dental root
2.4
11.0
76
329
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
10.9
181
1090
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
2.8
10.8
55
205
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
4.5
10.8
26
59
J01MA02
ATC
ciprofloxacin; systemic
1.6
10.8
320
2257
D86.0
ICD-10 Finland
Sarcoidosis of lung
5.7
10.7
20
36
R01AD12
ATC
fluticasone furoate; nasal
1.6
10.6
353
2555
D68.3
ICD-10 Finland
Haemorrhagic disorder due to circulating anticoagulants
60.7
10.6
12
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
10.6
180
1091
I82.9
ICD-10 Finland
Embolism and thrombosis of unspecified vein
4.6
10.5
25
56
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
4.7
10.5
24
52
B02BD06
ATC
von Willebrand factor and coagulation factor VIII in combination; parenteral, topical, urethral
+∞
10.4
10
*
I80.9
ICD-10 Finland
Phlebitis and thrombophlebitis of unspecified site
5.2
10.3
21
41
SAA03
NOMESCO Finland
Extended examination of mouth
1.6
10.2
426
3243
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.3
10.2
39
123
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
10.2
208
1328
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
10.0
294
2059
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.4
10.0
72
318
C03CA01
ATC
furosemide; systemic
1.8
10.0
190
1187
R03AC02
ATC
salbutamol; inhalant
1.6
9.8
555
4510
R79.9
ICD-10 Finland
Abnormal finding of blood chemistry, unspecified
9.7
9.8
19
20
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.9
9.7
127
706
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.1
9.7
93
463
DKW00
NOMESCO Finland
Cauterisation of mucosa of nose
5.4
9.7
19
36
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.4
9.7
69
304
J01FA10
ATC
azithromycin; systemic
1.6
9.5
594
4917
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.7
9.5
51
196
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
9.5
240
1618
Z3226
NOMESCO Finland
Physiotherapist
1.8
9.4
172
1062
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
2.1
9.4
97
497
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.4
9.4
66
289
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
7.0
9.3
22
32
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.0
9.3
114
620
Z71.8
ICD-10 Finland
Other specified counselling
1.5
9.2
361
2696
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.1
9.2
91
459
3AC01, ,
NOMESCO Finland
7.8
9.2
20
26
D50.8
ICD-10 Finland
Other iron deficiency anaemias
4.5
8.9
21
47
R58
ICD-10 Finland
Haemorrhage, not elsewhere classified
4.5
8.9
21
47
P01AB01
ATC
metronidazole; oral, rectal
1.5
8.8
396
3035
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
8.7
126
724
I87.0
ICD-10 Finland
Postthrombotic syndrome
14.2
8.7
14
10
M25.5
ICD-10 Finland
Pain in joint
1.5
8.6
337
2504
TPH07
NOMESCO Finland
Cathetrisation of artery
2.1
8.6
87
442
ZXD05
NOMESCO Finland
Urgent procedure
1.6
8.6
290
2088
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
2.7
8.6
45
171
S06.0
ICD-10 Finland
Concussion
1.9
8.5
113
631
J01AA02
ATC
doxycycline; systemic
1.6
8.5
697
6045
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
8.5
518
4220
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.5
8.5
329
2441
Z2221
NOMESCO Finland
Medical doctor
1.6
8.4
270
1919
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
8.4
298
2167
SPAT1229
SPAT
Assessment of need for aid
2.3
8.4
60
265
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.7
8.4
179
1152
28610
ICD-8 Finland
Coagulation defects, Christmas disease
+∞
8.3
8
*
2BDXX, ,
NOMESCO Finland
+∞
8.3
8
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.2
8.3
72
344
ZXE20
NOMESCO Finland
More than three and less than five hours
1.9
8.3
113
636
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.4
8.3
55
234
N06AX22
ATC
agomelatine; oral
3.0
8.3
36
123
9981A
ICD-9 Finland
Other complications of procedures, not elsewhere classified, Haemorrhage or haematoma complicating a procedure
9.6
8.3
16
17
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.9
8.2
103
564
H02AB04
ATC
methylprednisolone; systemic
1.8
8.2
133
791
A07DA03
ATC
loperamide; oral
3.1
8.2
33
108
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.8
8.2
130
769
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.9
8.1
107
596
D64.9
ICD-10 Finland
Anaemia, unspecified
2.1
8.1
77
383
4511A
ICD-9 Finland
Phlebitis and thrombophlebitis, Of deep vessels of lower extremities
9.0
8.1
16
18
Z83.2
ICD-10 Finland
Family history of diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
22.2
8.0
11
5
K99
ICPC
Cardiovascular disease other
4.3
8.0
20
47
K92.1
ICD-10 Finland
Melaena
2.6
7.9
44
172
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.0
7.9
35
121
N02BF01
ATC
gabapentin; oral
1.9
7.9
104
580
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.8
7.9
128
762
R55
ICD-10 Finland
Syncope and collapse
2.0
7.8
90
479
I80.20
ICD-10 Finland
Phlebitis and thrombophlebitis in the iliac vein
10.9
7.8
14
13
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.8
7.8
132
795
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.4
7.8
53
229
ZXA10
NOMESCO Finland
Bilateral
1.7
7.8
155
978
K02.9
ICD-10 Finland
Dental caries, unspecified
3.5
7.7
26
76
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
3.3
7.7
28
86
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
2.2
7.7
63
295
SHA04
NOMESCO Finland
Stomatognathic treatment, very demanding
3.8
7.7
23
62
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
1.9
7.6
104
587
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
7.6
118
693
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
7.5
178
1173
R03AC03
ATC
terbutaline; inhalant
1.7
7.5
134
819
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
7.5
146
914
N03AX12
ATC
[U] gabapentin; oral
1.7
7.5
146
914
C07AB07
ATC
bisoprolol; oral
1.5
7.5
346
2646
A06AD11
ATC
lactulose; oral
1.9
7.5
101
568
D68
ICD-10 Finland
Other coagulation defects
80.7
7.4
8
*
3A149, ,
NOMESCO Finland
80.7
7.4
8
*
H04.10
ICD-10 Finland
Dry eye syndrome
1.8
7.4
124
744
R31
ICD-10 Finland
Unspecified haematuria
2.1
7.4
71
354
SPAT1263
SPAT
Sampling
1.5
7.4
378
2948
A46
ICD-10 Finland
Erysipelas
1.8
7.4
109
630
M79.7
ICD-10 Finland
Fibromyalgia
2.5
7.3
45
185
B02BD04
ATC
coagulation factor IX; parenteral
+∞
7.3
7
*
2BD02, ,
NOMESCO Finland
+∞
7.3
7
*
SAA04
NOMESCO Finland
Special examination of mouth
2.1
7.3
65
315
JN3AD
NOMESCO Finland
Abdominal CT examination
1.8
7.3
113
663
J45.1
ICD-10 Finland
Nonallergic asthma
2.1
7.3
72
363
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
7.3
563
4745
SXB00
NOMESCO Finland
Removal of sutures from oral mucosa
2.1
7.2
69
344
LCA06
NOMESCO Finland
Biopsy of endometrium
1.7
7.2
129
790
J01FA06
ATC
roxithromycin; oral
1.5
7.2
352
2719
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.9
7.2
93
516
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
2.7
7.1
38
146
N02AC04
ATC
dextropropoxyphene; oral
3.1
7.1
29
96
R06AE07
ATC
cetirizine; oral
1.4
7.1
434
3494
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.0
7.1
77
402
R60.0
ICD-10 Finland
Localized oedema
1.8
7.1
105
608
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.0
7.0
74
382
A02BC02
ATC
pantoprazole; systemic
1.5
7.0
592
5053
WX002
NOMESCO Finland
Sedation and analgesia
1.7
7.0
154
995
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.8
7.0
109
641
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
1.9
7.0
85
462
Z01.2
ICD-10 Finland
Dental examination
1.4
7.0
468
3829
A03FA01
ATC
metoclopramide; systemic, rectal
1.6
7.0
201
1388
R5599
NOMESCO Finland
Other rehabilitation service
2.8
7.0
33
119
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.7
6.9
130
807
UJF30
NOMESCO Finland
Ileoscopy through colon
1.8
6.8
95
539
B01AB10
ATC
tinzaparin; parenteral
1.8
6.8
96
547
M54.4
ICD-10 Finland
Lumbago with sciatica
1.6
6.7
175
1178
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
2.7
6.7
35
133
R52.2
ICD-10 Finland
Other chronic pain
2.4
6.7
43
181
L28
ICPC
Limited function/disability (L)
1.7
6.7
142
909
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
6.7
192
1323
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.3
6.7
50
226
J45
ICD-10 Finland
Asthma
1.8
6.6
106
627
C01DA14
ATC
isosorbide mononitrate; oral
1.9
6.6
80
433
N02AA05
ATC
oxycodone; systemic
1.7
6.6
125
776
I84.9
ICD-10 Finland
Unspecified hemorrhoids without complication
2.5
6.6
42
176
M01AG02
ATC
tolfenamic acid; oral, rectal
1.6
6.4
161
1076
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.5
6.4
204
1440
M03BC51
ATC
orphenadrine, combinations; systemic
1.5
6.3
245
1799
J01CA04
ATC
amoxicillin; systemic
1.6
6.3
794
7246
W84
ICPC
Pregnancy high risk
2.2
6.3
51
238
D69.8
ICD-10 Finland
Other specified haemorrhagic conditions
18.2
6.3
9
5
O991, D680,
ICD-10 Finland
+∞
6.3
6
*
B83
ICPC
Purpura/coagulation defect
+∞
6.3
6
*
R52.9
ICD-10 Finland
Pain, unspecified
1.8
6.2
101
600
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.0
6.2
68
356
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
6.2
225
1629
J01EA01
ATC
trimethoprim; systemic
1.5
6.2
239
1753
ZXA05
NOMESCO Finland
Left side
1.6
6.1
178
1228
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.8
6.1
91
527
I80.1
ICD-10 Finland
Phlebitis and thrombophlebitis of femoral vein
4.2
6.1
16
39
SPAT1104
SPAT
Monitoring of emergency patient
2.2
6.1
52
248
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
2.1
6.1
55
269
E0000UV, ,
ATC
1.4
6.1
387
3114
K07.60
ICD-10 Finland
Snapping jaw
2.0
6.0
68
360
EBB10
NOMESCO Finland
Insertion of dental implant
3.5
6.0
20
58
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.9
6.0
74
404
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
2.2
6.0
51
243
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
419
274
26.51
307.65
7.8
3.0
116.11
178.62
%
22.57
399
264
320
277
16.89
307.65
4.7
3.2
3.20
3.56
g/l
3.57
298
263
475
1114
7.51
213.89
4.7
2.2
32.00
29.38
s
5.11
455
1079
123
30
46.93
207.09
1.4
1.1
93.55
96.32
%
0.12
69
19
122
30
46.49
204.97
1.3
1.0
95.55
91.84
%
0.23
66
19
244
311
10.20
187.86
5.5
2.9
97.97
94.89
%
1.21
237
298
109
8
153.59
104.52
1.7
1.6
—
—
—
0
0
483
2045
3.76
88.85
7.9
3.8
92.40
94.09
%
0.63
464
1992
351
1265
3.81
81.06
5.2
3.9
0.82
0.82
mmol/l
0.69
338
1211
459
2007
3.48
77.87
3.9
1.9
0.72
1.01
mg/l
2.52
345
1517
571
3187
2.97
58.40
23.8
10.4
1.35
1.15
inr
11.47
490
2656
50
0
+∞
52.59
1.5
0.0
51.93
—
%
—
44
0
276
1102
3.12
50.82
4.4
2.5
23.36
23.27
%
0.04
268
1030
189
633
3.48
46.15
3.2
2.5
83.46
73.02
ml/min/173m2
3.77
143
260
562
3370
2.63
45.78
6.6
4.9
37.12
36.60
g/l
1.49
525
3201
286
1228
2.90
45.60
4.2
2.5
2.45
2.40
g/l
1.07
274
1132
299
1325
2.83
44.83
4.2
2.5
14.39
13.98
umol/l
0.44
289
1233
298
1470
2.49
34.64
4.1
2.5
2.42
2.43
mmol/l
1.41
279
1321
191
758
2.90
34.26
3.4
4.8
222.72
250.08
u/l
1.16
180
722
458
2744
2.29
33.91
4.0
3.3
2.36
2.36
mmol/l
0.12
426
2529
382
2167
2.27
31.73
3.8
2.3
2.67
2.70
mg/l
0.11
336
1886
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
74
176
4.47
28.91
5.7
4.2
0.31
0.38
iu/ml
0.97
43
87
70
162
4.58
28.29
1.4
1.2
4.12
5.00
u/ml
0.20
40
70
70
163
4.56
28.07
1.4
1.2
3.03
3.61
u/ml
0.11
29
61
562
3840
2.13
27.92
8.7
7.1
1.21
1.21
mmol/l
0.03
486
3351
592
4161
2.12
26.84
6.6
6.3
10.52
10.94
umol/l
0.27
565
3967
664
4906
2.17
25.98
9.9
9.5
4.01
3.98
e9/l
0.15
608
4303
63
144
4.61
25.84
1.2
1.2
105.07
115.59
%
1.60
57
133
65
153
4.49
25.70
1.1
1.1
—
—
—
0
0
781
6198
2.44
25.15
9.6
7.7
74.74
77.27
u/l
1.07
751
5898
506
3424
2.02
24.62
9.2
6.4
1.22
1.22
mmol/l
0.09
478
3179
551
3885
1.99
23.36
13.9
10.3
0.00
0.00
e9/l
0.77
470
3184
40
70
5.92
22.10
1.3
1.5
12.40
10.63
umol/l
1.02
40
63
609
4601
1.90
19.30
6.5
4.9
6.30
6.49
mmol/l
1.29
588
4291
613
4676
1.87
18.44
5.1
3.2
89.78
90.88
ug/l
0.06
588
4444
531
3932
1.79
17.00
3.7
2.7
—
—
estimate
—
0
0
750
6181
2.00
16.99
5.6
4.3
9.50
10.43
mm/h
1.40
720
5837
273
1697
1.85
15.34
2.8
2.7
5.63
6.76
e6/l
0.63
248
1525
371
2533
1.76
15.21
3.6
3.2
25.05
73.86
e6/l
1.08
297
1876
329
2178
1.78
14.95
3.5
3.0
0.26
0.35
e6/l
0.73
261
1534
14
0
+∞
14.62
2.9
0.0
—
—
—
0
0
13
0
+∞
13.57
1.5
0.0
—
—
—
0
0
302
2017
1.73
12.94
3.1
2.2
—
—
—
0
0
902
8233
2.79
12.25
22.6
14.8
3.91
3.93
mmol/l
1.68
893
8061
900
8217
2.71
12.01
22.7
14.7
139.60
139.65
mmol/l
0.27
891
8068
377
2749
1.61
11.15
3.6
3.4
23.30
71.61
ng/l
1.03
223
1646
504
3947
1.59
10.97
3.2
2.6
75.38
75.50
nmol/l
0.03
481
3659
400
2969
1.60
10.93
3.7
3.3
27.13
29.80
u/l
1.73
377
2825
351
2527
1.62
10.87
2.6
2.5
55.81
60.79
u/l
0.66
331
2354
863
7818
2.10
10.39
18.6
12.2
88.40
87.79
ml/min/173m2
0.36
811
7115
110
569
2.05
10.37
6.0
3.5
1.23
1.23
mmol/l
0.31
100
481
899
8323
2.41
9.47
20.8
13.4
19.29
21.14
mg/l
1.01
793
6725
268
1857
1.62
9.47
3.1
3.2
1207.88
994.15
ng/l
0.40
215
1550
83
412
2.11
8.72
1.7
2.0
6.24
6.32
iu/ml
0.01
21
95
149
908
1.76
8.47
2.4
2.1
357.74
380.14
nmol/l
0.84
140
848
258
1824
1.57
8.20
1.4
1.3
24.66
27.40
iu/ml
0.14
72
559
805
7252
1.71
8.19
25.6
16.7
13.59
13.44
%
2.58
799
7177
122
708
1.83
8.16
2.9
3.0
9.54
10.46
g/l
2.29
114
660
23
63
3.72
7.49
1.2
1.1
—
—
—
0
0
157
1003
1.68
7.49
9.1
6.4
1.06
1.07
mmol/l
0.20
147
927
918
8688
2.54
7.24
15.4
11.0
25.27
25.32
u/l
0.04
908
8500
235
1668
1.54
7.23
1.4
1.3
27.49
12.58
u/ml
0.40
94
694
202
1387
1.58
7.19
4.0
3.5
367.76
352.21
ng/l
0.03
132
907
179
1201
1.60
7.01
2.2
1.8
—
—
—
0
0
324
2472
1.47
7.00
4.7
3.7
0.00
0.01
estimate
1.54
145
902
120
726
1.75
6.97
2.5
2.7
0.22
0.22
g/l
0.00
115
688
266
1956
1.50
6.89
3.2
2.7
322.27
321.74
umol/l
0.03
238
1763
420
3381
1.43
6.76
2.2
2.0
100.78
97.16
pmol/l
0.74
241
1812
120
734
1.73
6.70
10.9
9.3
0.98
0.91
mmol/l
0.07
100
605
148
960
1.64
6.63
3.9
3.1
8.20
7.22
umol/l
0.14
124
838
633
5505
1.45
6.56
5.5
4.3
143.91
1086.40
e6/l
1.03
11
72
107
638
1.76
6.53
3.3
3.7
4.53
4.60
pmol/l
0.28
96
565
116
708
1.73
6.52
3.5
3.0
—
—
—
0
0
299
2277
1.46
6.41
2.4
2.1
165.88
231.06
u/l
0.57
292
2168
765
6925
1.53
6.30
5.8
4.6
14.52
14.49
pmol/l
0.16
730
6513
62
313
2.05
6.27
1.7
1.7
0.22
0.24
g/l
1.03
62
297
131
836
1.66
6.24
2.1
1.8
—
—
—
0
0
540
4586
1.41
6.23
4.5
3.6
0.00
4.76
estimate
1.08
153
953
134
870
1.63
5.96
2.0
1.8
—
—
—
0
0
115
718
1.68
5.95
1.4
1.3
79.57
217.79
u/ml
2.65
106
665
63
327
1.99
5.92
1.7
1.7
1.13
1.20
g/l
1.16
63
309
179
1246
1.54
5.91
3.1
2.8
2.72
3.24
e6/l
0.39
95
581
532
4540
1.39
5.77
4.5
3.6
0.00
0.00
estimate
0.50
152
942
274
2102
1.43
5.51
1.8
1.5
2.15
2.21
g/l
0.31
186
1326
537
4624
1.37
5.32
4.5
3.6
0.02
0.34
estimate
0.48
148
910
188
1352
1.49
5.29
3.1
2.6
0.55
0.97
e6/l
3.52
105
680
15
30
5.06
5.26
2.6
1.9
51.17
66.25
ug/l
0.40
15
30
186
1342
1.48
5.14
2.3
2.6
89.57
105.48
ug/g
0.56
147
1079
69
389
1.83
5.10
1.7
1.6
—
—
—
0
0
418
3505
1.34
4.71
4.4
3.4
0.00
0.04
estimate
3.42
124
799
54
289
1.92
4.69
1.3
1.2
3.93
2.84
u/ml
—
7
26
74
438
1.75
4.67
3.0
3.2
173.81
144.20
ng/l
0.26
68
403
414
3471
1.34
4.66
2.1
1.9
1.45
1.35
mmol/l
1.33
362
3022
54
291
1.91
4.60
1.3
1.3
2.75
12.22
u/ml
1.14
11
47
844
7934
1.56
4.55
6.8
5.5
1.79
1.81
mu/l
0.24
803
7525
53
285
1.91
4.55
1.5
2.0
1.36
1.46
g/l
0.42
45
251
56
307
1.88
4.54
1.3
1.2
45.02
13.61
u/ml
—
5
16
89
560
1.65
4.49
3.0
3.0
66.53
67.34
g/l
0.58
82
524
302
2427
1.36
4.45
1.5
1.4
0.60
1.82
u/ml
3.58
102
667
40
196
2.09
4.45
2.6
2.9
3.38
2.24
index
0.53
21
102
98
634
1.61
4.43
2.3
2.3
3262.53
5646.31
u/l
0.63
37
271
27
112
2.45
4.42
1.0
1.2
—
—
—
0
0
24
95
2.57
4.32
1.0
1.2
—
—
—
0
0
25
103
2.47
4.16
1.0
1.1
—
—
—
0
0
41
209
2.00
4.12
2.0
2.0
0.00
0.00
g/l
-0.00
36
182
24
99
2.46
3.99
1.0
1.2
—
—
—
0
0
24
99
2.46
3.99
1.0
1.2
—
—
—
0
0
689
6303
1.34
3.86
3.8
3.5
—
—
—
0
0
270
2176
1.34
3.82
1.8
1.6
20.37
20.77
nmol/l
0.17
237
1890
24
102
2.39
3.76
1.1
1.1
—
—
—
0
0
32
154
2.12
3.76
4.5
3.0
9.88
8.00
pmol/l
0.35
32
154
317
2623
1.31
3.71
3.6
3.0
0.02
0.11
estimate
0.71
125
782
83
540
1.59
3.69
1.8
1.7
—
—
—
0
0
34
169
2.05
3.68
3.5
3.9
5.78
2.88
ratio
0.29
21
95
112
783
1.49
3.60
2.5
2.4
210.61
97.75
u/l
0.26
103
652
45
250
1.84
3.55
1.3
1.2
52.07
42.18
u/ml
—
7
23
62
385
1.65
3.35
2.7
2.2
43.14
40.28
u/l
0.44
57
352
37
197
1.91
3.34
1.7
1.5
—
—
—
0
0
93
639
1.50
3.27
2.3
2.4
11.57
21.46
au/ml
—
6
73
21
90
2.36
3.26
2.0
1.9
33.33
32.26
pg
0.75
21
90
36
192
1.91
3.24
2.0
2.1
0.00
0.00
g/l
-0.00
36
181
22
97
2.30
3.21
1.0
1.2
—
—
—
0
0
36
195
1.88
3.10
1.2
1.2
—
—
—
0
0
10
25
4.03
3.09
2.7
3.0
0.63
0.62
mmol/l
—
10
25
87
601
1.49
2.99
1.6
1.4
—
—
—
0
0
39
220
1.81
2.97
1.4
1.6
—
—
—
0
0
306
2591
1.27
2.86
3.7
3.4
7.27
7.82
mmol/l
1.39
262
2258
24
116
2.10
2.84
2.4
1.7
23.24
25.85
ng/l
0.24
24
116
39
224
1.77
2.82
1.4
1.6
—
—
—
0
0
49
301
1.66
2.79
2.0
2.2
2.69
4.31
iu/l
2.07
19
130
12
39
3.10
2.77
2.8
4.4
0.92
0.79
index
0.29
12
39
41
241
1.73
2.74
2.1
1.9
1.89
2.42
ug/l
0.14
36
221
17
73
2.35
2.66
1.2
1.4
—
—
—
0
0
14
55
2.57
2.62
1.1
1.1
1867.64
1528.47
miu/ml
0.56
14
55
144
1115
1.34
2.62
1.8
1.7
1130.23
1176.68
nmol/l
0.24
111
858
23
114
2.04
2.58
1.1
1.1
1.37
1.43
g/l
0.29
23
106
11
36
3.08
2.57
1.0
1.3
—
—
—
0
0
15
62
2.44
2.55
2.7
2.6
—
—
—
0
0
931
9111
1.95
2.54
33.1
20.8
4.50
4.50
e12/l
0.03
926
8955
87
623
1.44
2.52
4.3
4.3
83.95
76.06
ng/l
0.29
78
560
111
833
1.38
2.47
1.3
1.3
160.28
147.99
u/ml
0.11
41
341
20
97
2.08
2.38
1.5
1.5
—
—
—
0
0
643
5979
1.23
2.36
4.0
3.3
44.65
40.26
u/l
0.70
606
5740
98
726
1.39
2.36
5.5
4.4
2.20
1.76
mmol/l
0.66
91
617
263
2232
1.25
2.35
1.8
1.7
—
—
—
0
0
58
390
1.52
2.31
1.7
1.4
—
—
—
0
0
74
526
1.44
2.25
5.9
4.1
5.19
5.13
kpa
0.30
67
509
34
202
1.71
2.24
1.4
1.5
—
—
—
0
0
12
48
2.52
2.19
1.9
3.0
576.67
580.96
u/ml
0.01
12
48
8
24
3.35
2.18
1.1
1.0
88.63
97.25
%
—
8
24
239
2024
1.24
2.17
4.5
3.6
1.02
1.02
kg/l
0.18
174
1322
29
168
1.75
2.09
1.2
1.3
—
—
—
0
0
29
168
1.75
2.09
1.4
1.7
—
—
—
0
0
5
10
5.02
2.07
1.6
1.8
—
—
—
0
0
27
154
1.78
2.06
2.1
2.1
5.55
4.99
mmol/24h
0.39
22
136
50
335
1.52
2.05
1.2
1.3
—
—
—
0
0
6
15
4.02
2.04
12.2
9.5
5.42
4.95
kpa
—
6
15
12
50
2.42
2.03
1.0
1.2
—
—
—
0
0
840
8100
1.31
1.99
5.4
4.6
4.66
4.73
mmol/l
1.13
798
7713
143
1153
1.28
1.96
1.6
1.7
1.47
1.39
%
0.42
121
1040
67
482
1.42
1.94
2.3
2.4
6.42
6.94
ug/l
0.10
59
431
64
458
1.43
1.91
6.6
4.2
1.63
1.67
mmol/l
0.03
44
330
34
212
1.63
1.91
13.9
4.2
1.13
1.31
mmol/l
0.99
34
207
38
244
1.58
1.90
1.7
1.4
321.23
310.15
ug/g
0.11
23
135
798
7658
1.26
1.88
4.6
3.9
1.34
1.24
mmol/l
1.99
759
7220
5
12
4.18
1.82
2.6
1.9
—
—
—
0
0
16
80
2.02
1.80
1.1
1.1
—
61.88
—
0
8
16
80
2.02
1.80
1.7
1.7
—
—
—
0
0
30
184
1.65
1.80
3.3
2.2
136.80
130.64
g/l
0.64
25
152
24
139
1.75
1.77
1.3
1.3
—
—
—
0
0
24
139
1.75
1.77
1.3
1.3
—
—
—
0
0
835
8069
1.28
1.76
5.3
4.5
1.44
1.50
mmol/l
4.78
791
7646
18
95
1.91
1.76
1.1
1.4
—
—
—
0
0
9
36
2.51
1.74
1.0
1.4
—
—
—
0
0
28
171
1.66
1.72
1.1
1.1
—
—
—
0
0
18
96
1.89
1.71
1.1
1.4
—
—
—
0
0
23
133
1.75
1.71
1.4
1.7
—
—
—
0
0
12
55
2.20
1.68
1.1
1.1
11.75
7.53
mm/h
0.48
12
55
844
8176
1.28
1.67
5.9
5.1
2.76
2.79
mmol/l
0.49
800
7756
47
327
1.46
1.66
1.4
1.3
—
—
—
0
0
10
41
2.45
1.64
1.9
4.2
25.20
126.63
umol/l
—
5
24
17
91
1.88
1.61
1.6
1.6
—
—
—
0
0
783
7530
1.22
1.61
6.3
5.5
38.19
38.18
mmol/mol
0.01
731
7186
26
159
1.65
1.60
1.4
1.4
—
—
—
0
0
42
289
1.47
1.57
1.3
1.1
6.98
4.35
—
5
42
34
224
1.54
1.56
1.6
1.3
—
59.14
—
0
7
32
208
1.56
1.56
1.6
1.3
231.35
243.78
u/ml
0.11
20
125
85
662
1.31
1.55
2.8
4.4
2.86
34.88
ug/l
1.54
62
533
18
100
1.82
1.53
1.2
1.5
—
—
—
0
0
9
37
2.45
1.48
1.0
1.3
—
—
—
0
0
9
37
2.45
1.48
1.0
1.3
—
—
—
0
0
5
16
3.14
1.44
1.0
1.2
—
—
—
0
0
17
95
1.80
1.43
1.1
1.4
—
—
—
0
0
12
60
2.01
1.38
3.1
3.8
12.83
12.85
index
0.00
12
39
6
23
2.62
1.37
1.0
1.0
—
—
—
0
0
28
183
1.55
1.35
1.8
1.6
145.30
149.54
au/ml
—
10
60
47
342
1.39
1.34
3.3
3.9
50.88
50.05
%
0.08
47
337
192
1667
1.19
1.34
2.5
2.3
—
—
—
0
0
22
136
1.63
1.33
1.5
1.4
—
—
—
0
0
256
2280
1.17
1.32
4.6
4.2
10.59
9.24
mg/mmol
0.20
163
1440
30
201
1.51
1.31
2.4
2.8
—
—
—
0
0
6
24
2.51
1.30
3.3
5.0
—
—
—
0
0
14
76
1.85
1.30
1.0
1.1
—
—
—
0
0
8
35
2.30
1.27
1.3
1.2
—
—
—
0
0
8
36
2.23
1.24
1.1
1.2
—
—
—
0
0
50
374
1.36
1.23
2.8
3.4
1.33
1.24
%
0.23
50
374
20
124
1.63
1.21
1.2
1.3
—
—
—
0
0
58
446
1.32
1.20
1.7
1.5
—
—
—
0
0
49
368
1.35
1.18
2.9
3.3
0.61
0.62
%
0.06
49
368
36
257
1.42
1.17
1.3
1.2
—
—
—
0
0
36
257
1.42
1.17
1.3
1.2
—
—
—
0
0
17
102
1.68
1.16
1.1
1.4
—
—
—
0
0
68
537
1.29
1.16
1.4
1.4
—
—
—
0
0
181
1584
1.18
1.16
1.9
1.7
475.02
42212952.63
pmol/l
2.21
149
1374
108
901
1.22
1.16
2.2
1.9
—
—
—
0
0
15
87
1.74
1.15
1.3
1.2
0.26
1.42
u/ml
—
9
46
50
379
1.34
1.14
1.9
1.8
—
—
—
0
0
29
412
0.69
1.14
1.1
1.1
1.49
1.58
g/l
1.11
29
412
17
103
1.66
1.13
1.1
1.4
—
—
—
0
0
17
103
1.66
1.13
1.1
1.4
—
—
—
0
0
19
119
1.61
1.12
1.5
1.3
—
—
—
0
0
7
31
2.27
1.10
1.0
1.4
—
—
—
0
0
28
194
1.46
1.07
1.2
1.4
—
—
—
0
0
128
1096
1.19
1.07
2.3
2.0
—
—
—
0
0
96
802
1.22
1.03
1.5
1.5
19.93
24.22
iu/l
0.96
81
676
15
91
1.66
1.01
1.8
1.3
—
—
—
0
0
798
7770
1.17
0.99
5.0
4.5
5.80
5.76
mmol/l
0.36
740
7284
13
76
1.72
0.99
3.4
1.7
—
—
—
0
0
13
76
1.72
0.99
1.1
1.1
105.31
113.50
pmol/l
0.31
13
76
5
23
2.18
0.98
1.0
1.2
—
—
—
0
0
54
425
1.29
0.98
1.7
1.5
0.22
0.32
mg/l
0.66
20
184
31
422
0.73
0.98
1.3
1.1
0.88
0.87
g/l
0.09
31
422
9
52
1.74
0.92
1.2
1.1
—
—
—
0
0
6
29
2.08
0.89
1.5
1.5
10.46
8.09
ug/l
—
6
29
10
56
1.79
0.88
1.2
1.4
—
—
—
0
0
10
56
1.79
0.88
1.4
3.2
160.60
1082.32
mg
—
10
56
6
30
2.01
0.87
1.0
1.3
—
—
—
0
0
6
30
2.01
0.87
1.0
1.3
—
—
—
0
0
6
30
2.01
0.87
1.0
1.3
—
—
—
0
0
12
72
1.68
0.85
1.1
1.0
—
—
—
0
0
170
1522
1.14
0.83
2.5
2.1
—
—
—
0
0
16
105
1.53
0.82
1.3
1.1
—
—
—
0
0
6
33
1.82
0.79
1.3
1.5
—
—
—
0
0
20
140
1.44
0.77
1.6
1.5
—
—
—
0
0
24
175
1.38
0.75
1.4
1.5
—
—
—
0
0
15
100
1.51
0.73
1.3
1.1
—
—
—
0
0
5
25
2.01
0.72
1.2
1.0
—
—
—
0
0
10
60
1.67
0.72
1.0
1.1
—
—
—
0
0
37
291
1.28
0.72
2.8
1.9
—
—
—
0
0
12
76
1.59
0.72
1.3
1.3
—
—
—
0
0
9
58
1.56
0.70
1.2
1.3
74.78
72.79
umol/l
—
9
58
91
791
1.17
0.68
6.7
6.0
—
—
—
0
0
12
77
1.57
0.68
1.3
1.3
—
—
—
0
0
16
110
1.46
0.68
1.1
1.2
—
—
—
0
0
23
170
1.36
0.68
1.7
1.8
—
—
—
0
0
14
94
1.50
0.67
1.1
1.1
—
—
—
0
0
32
250
1.29
0.66
2.7
3.1
1569.28
1689.31
u/ml
0.02
27
222
5
28
1.79
0.66
1.6
1.4
—
—
—
0
0
54
450
1.21
0.65
1.2
1.3
201.80
231.76
miu/ml
0.26
25
231
14
95
1.48
0.64
1.1
1.2
—
—
—
0
0
33
261
1.27
0.63
1.2
1.3
—
—
—
0
0
8
52
1.54
0.59
1.1
1.6
—
—
—
0
0
19
254
0.74
0.59
1.1
1.1
0.49
1.99
u/ml
—
8
141
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
53
1.51
0.58
1.1
1.1
—
—
—
0
0
43
356
1.22
0.57
1.7
1.5
13.20
9.53
u/l
0.52
32
282
6
36
1.67
0.56
1.0
1.2
90.17
96.73
nmol/l
—
6
27
6
37
1.63
0.55
3.8
2.2
104.22
110.69
ng/l
—
6
37
6
37
1.63
0.55
1.0
1.0
—
—
—
0
0
44
367
1.21
0.55
1.5
1.7
5.84
10.12
u/ml
—
8
94
33
267
1.24
0.54
1.2
1.4
119.97
121.06
pmol/l
0.01
33
260
6
99
0.60
0.52
2.7
1.8
—
—
—
0
0
6
40
1.50
0.51
1.5
1.7
—
—
—
0
0
6
40
1.50
0.51
1.5
1.7
—
—
—
0
0
6
40
1.50
0.51
1.0
1.1
194.00
166.63
iu/ml
—
6
40
11
75
1.47
0.51
1.6
1.5
—
—
—
0
0
11
75
1.47
0.51
1.6
1.5
—
—
—
0
0
11
75
1.47
0.51
1.6
1.5
—
—
—
0
0
32
266
1.21
0.43
2.8
1.8
—
—
—
0
0
5
31
1.62
0.43
1.8
2.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
7.58
—
0
11
21
260
0.80
0.40
1.1
1.1
1.57
6.23
u/ml
3.21
12
154
8
60
1.34
0.40
2.4
2.3
—
—
—
0
0
44
385
1.15
0.36
1.7
1.6
—
—
—
0
0
17
212
0.80
0.36
2.9
1.6
38.24
40.96
nmol/l
0.22
17
204
96
882
1.10
0.36
4.6
4.3
30.88
31.91
%
0.39
67
636
6
44
1.37
0.34
2.7
1.7
—
84.14
%
—
0
7
6
46
1.31
0.33
1.3
1.6
—
—
—
0
0
6
46
1.31
0.33
1.3
1.6
—
—
—
0
0
6
46
1.31
0.33
1.3
1.6
—
—
—
0
0
6
46
1.31
0.33
1.3
1.6
—
—
—
0
0
13
165
0.78
0.32
1.2
1.1
166.29
3200.67
iu/ml
—
7
40
12
93
1.29
0.30
3.6
5.0
514.46
110.40
u/ml
—
5
32
8
64
1.25
0.27
1.3
1.4
—
—
—
0
0
35
310
1.13
0.26
5.8
3.9
25.92
25.14
mmol/l
0.74
35
299
5
71
0.70
0.26
1.2
2.6
1.20
1.19
mmol/l
—
5
71
5
72
0.69
0.26
1.2
2.6
105.20
105.96
mmol/l
—
5
72
64
588
1.09
0.26
1.1
1.1
—
—
—
0
0
12
149
0.80
0.26
3.0
1.8
145.92
204.65
pmol/l
0.98
12
141
22
188
1.17
0.25
1.5
1.7
4536.50
15137.60
e6/l
—
10
136
37
413
0.89
0.25
1.4
1.8
5.39
4.62
mg/l
0.15
26
302
27
238
1.14
0.22
1.9
1.5
0.29
0.41
nmol/l
0.99
22
196
49
534
0.91
0.22
1.6
1.4
—
—
—
0
0
5
42
1.19
0.21
2.0
1.6
—
—
—
0
0
34
377
0.90
0.21
1.7
1.9
—
—
—
0
0
18
209
0.86
0.21
1.3
1.3
—
—
—
0
0
23
203
1.14
0.19
1.3
1.1
5.33
15.50
au/ml
—
6
57
95
999
0.95
0.18
3.9
4.2
24.40
22.09
%
0.65
47
432
7
59
1.19
0.18
1.0
1.1
—
—
—
0
0
15
129
1.17
0.17
1.5
1.5
—
—
—
0
0
204
1982
1.04
0.16
1.7
1.5
—
—
—
0
0
23
206
1.12
0.16
3.3
2.7
4.96
6.80
umol/l
0.70
17
153
6
76
0.79
0.15
1.5
1.2
1.33
1.58
nmol/l
—
6
69
110
1144
0.96
0.15
1.8
1.9
3.55
3.34
ratio
0.90
78
875
32
295
1.09
0.14
1.7
1.5
62.70
57.13
ug/l
0.32
32
295
40
428
0.93
0.13
1.5
1.5
—
—
—
0
0
122
1260
0.96
0.12
5.0
4.9
1.88
2.11
ug/l
0.24
109
1141
19
174
1.09
0.09
1.2
1.1
0.76
2.56
eliau/ml
—
8
86
5
48
1.04
0.09
1.8
1.5
0.60
5.16
u/field
—
5
39
5
61
0.82
0.08
1.6
1.6
—
—
—
0
0
5
65
0.77
0.08
3.6
3.9
—
—
—
0
0
77
747
1.03
0.08
3.2
2.9
0.68
0.77
ug/l
0.41
51
448
7
68
1.03
0.08
2.0
1.1
7.59
5.64
umol/l
—
7
62
21
225
0.93
0.07
1.4
1.2
—
—
—
0
0
16
147
1.09
0.07
3.6
3.9
38.27
26.52
mg/l
0.51
11
105
83
811
1.03
0.05
1.7
1.6
796.11
1042.10
mu/l
2.07
66
675
28
293
0.95
0.05
1.3
1.1
1.16
2.60
u/ml
0.88
18
165
23
219
1.05
0.04
1.7
1.6
—
—
—
0
0
89
874
1.02
0.04
1.6
1.7
3.42
3.42
mmol/l
0.01
58
610
42
433
0.97
0.04
1.6
1.5
0.97
0.97
ratio
0.00
25
272
42
433
0.97
0.04
1.6
1.5
1.04
1.23
ratio
0.86
25
272
42
433
0.97
0.04
1.6
1.5
1.31
1.18
ratio
0.19
25
272
46
471
0.98
0.03
1.5
1.5
64.77
62.16
ug/l
0.08
34
395
42
430
0.98
0.02
1.6
1.5
—
—
—
0
0
34
344
0.99
0.00
2.0
1.8
—
—
—
0
0
10
102
0.98
0.00
2.8
2.6
24.39
23.47
nmol/l
—
10
97
10
95
1.05
0.00
1.3
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
8.37
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
67
0.89
-0.00
1.2
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
3.09
—
0
9
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.01
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_COAGDEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_COAGDEF | 1.541 [1.28, 1.85] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.136 |
During the follow-up period (1.1.1998 — 31.12.2019), 184 out of 3408 females with D3_COAGDEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_COAGDEF | 1.698 [1.39, 2.07] | < 0.001 |
| Birth year | 0.985 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 193 out of 1530 males with D3_COAGDEF died.
Mortality risk
Mortality risk for people of age
years, who have D3_COAGDEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.133% | 0.349% |
| 5 | 0.891% | 1.949% |
| 10 | 2.227% | 4.778% |
| 15 | 4.197% | 8.71% |
| 20 | 7.44% | 14.826% |
Relationships between endpoints
↥Index endpoint: D3_COAGDEF – Chronic Coagulation defects
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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