Lupus nephritis

M13_LUPUS_NEPHRITIS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

157

4. Check minimum number of events

None

157

5. Include endpoints

None

157

6. Filter based on genotype QC (FinnGen only)

138

Control definitions (FinnGen only)

Control exclude
AUTOIMMUNE

Extra metadata

Level in the ICD hierarchy
4

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 138 101 37
Unadjusted period prevalence (%) 0.03 0.04 0.02
Median age at first event (years) 39.95 38.41 44.14

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
148
Matched controls
1480
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
383.1
247.4
127
23
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
210.8
147
*
P01BA02
ATC
hydroxychloroquine; oral
169.2
190.8
100
18
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
3240.8
125.0
103
*
L04AA06
ATC
mycophenolic acid; systemic
608.1
122.4
106
6
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
103.7
87
*
L04AX01
ATC
azathioprine; systemic
392.6
93.4
85
5
C03CA01
ATC
furosemide; systemic
23.2
87.3
102
129
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
368.0
80.0
74
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
31.0
79.6
59
31
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
37.2
74.3
50
20
M05BA04
ATC
alendronic acid; oral
27.6
71.6
55
31
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
19.4
68.6
116
233
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
29.1
65.4
48
24
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
612.1
47.0
44
*
ZX120
NOMESCO Finland
Intravenous
13.5
44.5
50
54
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
21.5
43.3
35
21
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
10.9
43.1
60
87
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
14.7
42.0
43
40
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
41.6
38
*
205
Kela drug reimbursment
Chronic hypertension
10.0
41.4
64
105
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
40.5
37
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
181.0
40.0
40
*
H02AB07
ATC
prednisone; oral
10.2
39.2
56
83
H02AB04
ATC
methylprednisolone; systemic
9.4
38.8
62
105
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
38.2
35
*
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
37.0
34
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
48.1
35.1
42
12
GD1AA
NOMESCO Finland
Thorax X-ray examination
8.9
35.1
112
382
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
97.6
34.7
37
5
H02AB06
ATC
prednisolone; systemic
8.9
32.6
116
430
C09AA02
ATC
enalapril; systemic
8.2
32.3
56
102
A11CC03
ATC
alfacalcidol; systemic
67.2
32.0
36
7
KA1AE
NOMESCO Finland
Kidney ultrasound examination
45.8
31.5
38
11
A49.9
ICD-10 Finland
Bacterial infection, unspecified
10.1
31.0
41
54
TPH04
NOMESCO Finland
Cathetrisation of vein
7.1
30.9
69
163
M32
ICD-10 Finland
Systemic lupus erythematosus
+∞
30.2
28
*
C08CA02
ATC
felodipine; oral
11.8
29.1
33
35
TK800
NOMESCO Finland
Hemodialysis
89.3
26.9
29
*
L04AD01
ATC
ciclosporin; systemic
85.5
25.8
28
*
R50.9
ICD-10 Finland
Fever, unspecified
6.4
25.8
58
135
A12AA04
ATC
calcium carbonate; oral
156.4
25.5
26
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
156.4
25.5
26
*
C08CA01
ATC
amlodipine; oral
5.6
24.9
81
261
Z94.0
ICD-10 Finland
Kidney transplant status
149.2
24.4
25
*
H03AA01
ATC
levothyroxine sodium; systemic
8.5
23.7
35
52
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
20.9
22.2
33
20
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
6.1
22.2
50
115
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
21.4
20
*
B01AA03
ATC
warfarin; systemic
7.4
21.3
36
62
N18.0
ICD-10 Finland
End-stage renal disease
242.8
21.2
21
*
B03XA02
ATC
darbepoetin alfa; parenteral
39.0
21.0
26
8
N17.9
ICD-10 Finland
Acute renal failure, unspecified
39.0
21.0
26
8
127
Kela drug reimbursment
Transplant complication
56.8
20.9
24
5
C08CA05
ATC
nifedipine; systemic
18.2
20.6
32
22
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.5
20.5
52
132
137
Kela drug reimbursment
Uraemia requiring dialysis
+∞
20.3
19
*
N18.8
ICD-10 Finland
Other chronic renal failure
64.0
19.5
22
*
L04AX03
ATC
methotrexate; systemic
16.7
19.3
31
23
J01MA12
ATC
levofloxacin; systemic
5.2
19.1
51
135
ZX108
NOMESCO Finland
Inhalation
216.3
19.0
19
*
L93.0
ICD-10 Finland
Discoid lupus erythematosus
216.3
19.0
19
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
16.8
18.8
30
22
Z49.2
ICD-10 Finland
Other dialysis
+∞
18.1
17
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
18.1
17
*
73410
ICD-8 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
18.1
17
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
+∞
18.1
17
*
B05DA
ATC
Isotonic solutions
+∞
18.1
17
*
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
18.1
17
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
108.2
18.0
19
*
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
108.2
18.0
19
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
203.3
17.9
18
*
L04AA01
ATC
[U] ciclosporin
101.8
17.0
18
*
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
7.5
16.9
27
43
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
190.6
16.9
17
*
B01AB04
ATC
dalteparin; parenteral
8.2
16.6
24
34
C02AC05
ATC
moxonidine; oral
25.5
16.1
22
10
G05.8*M32.1
ICD-10 Finland
Encephalitis in systemic lupus erythematosus
+∞
15.9
15
*
B05DB
ATC
Hypertonic solutions
+∞
15.9
15
*
L01BA01
ATC
methotrexate; systemic
+∞
15.9
15
*
J01FF01
ATC
clindamycin; systemic
4.1
15.4
64
233
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
7.8
15.3
23
34
C09CA01
ATC
losartan; oral
4.2
15.2
56
187
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.1
15.1
38
94
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.2
15.0
55
183
H26.3
ICD-10 Finland
Drug-induced cataract
89.2
14.9
16
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
6.3
14.8
28
53
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
+∞
14.8
14
*
Z3231
NOMESCO Finland
Registered nurse
3.9
14.5
65
248
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
14.1
14.2
24
20
1XC02, ,
NOMESCO Finland
+∞
13.8
13
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
+∞
13.8
13
*
N32.9
ICD-10 Finland
Bladder disorder, unspecified
+∞
13.8
13
*
B03XA01
ATC
erythropoietin; parenteral
153.5
13.7
14
*
B07.9
ICD-10 Finland
Verruca simplex
12.2
13.3
24
23
A02BC02
ATC
pantoprazole; systemic
4.7
13.1
122
738
C09CA06
ATC
candesartan; oral
3.8
13.1
56
205
M04AA01
ATC
allopurinol; systemic
5.7
13.0
27
56
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
76.6
12.8
14
*
A12AA12
ATC
[U] calcium acetate
+∞
12.7
12
*
XX9XE
NOMESCO Finland
Other ultrasound examination
+∞
12.7
12
*
N04.9
ICD-10 Finland
Nephrotic syndrome, unspecified
+∞
12.7
12
*
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
17.9
12.5
19
12
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.6
12.4
26
54
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
6.5
12.4
22
39
N02AX02
ATC
tramadol; systemic, rectal
3.4
12.3
84
410
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
5.1
12.3
29
67
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.6
12.1
55
208
C08CA13
ATC
lercanidipine; oral
4.7
12.0
32
82
C10AA05
ATC
atorvastatin; oral
3.4
11.9
70
311
R80
ICD-10 Finland
Isolated proteinuria
33.1
11.9
15
5
L04AD02
ATC
tacrolimus; systemic
33.1
11.9
15
5
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.6
11.8
32
83
V03AE02
ATC
sevelamer; oral
+∞
11.6
11
*
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
11.6
11
*
N16.4*M32.1
ICD-10 Finland
Renal tubulo-interstitial disorders in systemic lupus erythematosus
+∞
11.6
11
*
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
11.6
11
*
L01AA01
ATC
cyclophosphamide; systemic
129.7
11.6
12
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
14.3
11.5
19
15
TPH07
NOMESCO Finland
Cathetrisation of artery
5.4
11.2
24
51
XF400
NOMESCO Finland
ECG with 12 standard connections
4.3
11.1
34
97
B01AB10
ATC
tinzaparin; parenteral
4.4
11.0
32
88
Z2446
NOMESCO Finland
Social worker
5.4
10.7
23
49
TK820
NOMESCO Finland
Peritoneal dialysis
+∞
10.5
10
*
L01BB01, ,
ATC
+∞
10.5
10
*
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
25.5
10.5
14
6
D64.9
ICD-10 Finland
Anaemia, unspecified
5.3
10.4
23
50
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
5.4
10.4
22
46
D07AB08
ATC
desonide; topical
4.2
10.0
30
84
I50.9
ICD-10 Finland
Heart failure, unspecified
5.4
9.9
21
44
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.4
9.9
28
75
UJF32
NOMESCO Finland
Coloscopy
3.4
9.8
45
169
Z2221
NOMESCO Finland
Medical doctor
3.0
9.7
64
297
XW000
NOMESCO Finland
Bone marrow biopsy
19.1
9.6
14
8
Z3226
NOMESCO Finland
Physiotherapist
3.4
9.6
42
153
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
+∞
9.5
9
*
G73.7*M32.1
ICD-10 Finland
Myopathy in systemic lupus erythematosus
+∞
9.5
9
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
+∞
9.5
9
*
N08.5*M31.7
ICD-10 Finland
Glomerular disease states in microscopic polyangiitis
+∞
9.5
9
*
N08.5*M30.0
ICD-10 Finland
Glomerular disorders in polyarteritis nodosa
+∞
9.5
9
*
196
Kela drug reimbursment
Paricalcitol and cinacalcet
+∞
9.5
9
*
C10AA01
ATC
simvastatin; oral
3.1
9.4
53
224
J05AB01
ATC
aciclovir; systemic
3.1
9.4
53
224
R4110
NOMESCO Finland
Physiotherapy
3.0
9.4
58
259
C07AB02
ATC
metoprolol; systemic
3.6
9.4
36
120
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.9
9.2
81
437
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.9
9.2
74
381
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.3
9.1
42
157
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
9.6
9.1
18
21
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
13.7
9.1
15
12
Z3229
NOMESCO Finland
Other healthcare associate professional
4.9
8.9
21
48
E0000UV, ,
ATC
2.8
8.9
81
443
J05AB11
ATC
valaciclovir; oral
3.3
8.8
41
154
K65.0
ICD-10 Finland
Acute peritonitis
53.2
8.8
10
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
53.2
8.8
10
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.9
8.8
29
87
J01MA14
ATC
moxifloxacin; systemic
4.2
8.7
26
72
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.2
8.7
45
180
A12BA01
ATC
potassium chloride; oral
21.6
8.6
12
6
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
7.9
8.6
19
27
J01FA06
ATC
roxithromycin; oral
2.8
8.5
73
384
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
95.3
8.5
9
*
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
95.3
8.5
9
*
V03AE01
ATC
polystyrene sulfonate; oral
95.3
8.5
9
*
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
+∞
8.4
8
*
TJA33
NOMESCO Finland
Percutaneous introduction of peritoneal dialysis catheter
+∞
8.4
8
*
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
15.7
8.4
13
9
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.9
8.2
19
43
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
23.6
8.1
11
5
D68.8
ICD-10 Finland
Other specified coagulation defects
23.6
8.1
11
5
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
7.7
8.1
18
26
A02BC03
ATC
lansoprazole; oral
2.9
8.0
52
235
GD1AD
NOMESCO Finland
Thorax CT examination
7.1
8.0
19
30
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
10.3
8.0
15
16
JN4AD
NOMESCO Finland
Body CT examination
4.2
8.0
23
62
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
47.5
7.8
9
*
C07AB07
ATC
bisoprolol; oral
2.6
7.8
72
390
L88
ICPC
Rheumatoid/seropositive arthritis
26.6
7.7
10
*
C02CA01
ATC
prazosin; oral
26.6
7.7
10
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.3
7.6
21
55
B02.9
ICD-10 Finland
Zoster without complication
4.6
7.5
19
46
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
14.4
7.5
12
9
E000001, ,
ATC
3.0
7.5
41
168
321
Kela drug reimbursment
Paricalcitol and cinacalcet
84.1
7.5
8
*
J01MA02
ATC
ciprofloxacin; systemic
2.6
7.5
66
348
ZXE20
NOMESCO Finland
More than three and less than five hours
3.5
7.4
29
97
I25.1
ICD-10 Finland
Atherosclerotic heart disease
3.8
7.4
25
76
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
6.7
7.4
18
30
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
16.8
7.3
11
7
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
+∞
7.3
7
*
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
+∞
7.3
7
*
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
+∞
7.3
7
*
N05.8
ICD-10 Finland
Unspecified nephritic syndrome, other
+∞
7.3
7
*
H04.10
ICD-10 Finland
Dry eye syndrome
3.5
7.2
28
93
UJF30
NOMESCO Finland
Ileoscopy through colon
4.1
7.2
21
57
M05BX04
ATC
denosumab; parenteral
7.0
7.2
17
27
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
14.7
7.0
11
8
M01AE01
ATC
ibuprofen; systemic, rectal
0.4
7.0
105
1292
C02EA02, ,
ATC
11.7
6.9
12
11
I10
ICD-10 Finland
Essential (primary) hypertension
2.5
6.8
85
521
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
6.8
49
232
NH3EA
NOMESCO Finland
Feet X-ray examination with load
23.8
6.8
9
*
C07AG02
ATC
carvedilol; oral
7.5
6.7
15
22
N19
ICD-10 Finland
Unspecified kidney failure
9.4
6.7
13
15
A63.0
ICD-10 Finland
Anogenital (venereal) warts
6.3
6.7
17
30
AA1AD
NOMESCO Finland
CT of head and brain
2.7
6.6
44
200
ZXE00
NOMESCO Finland
One hour or less
2.4
6.6
71
406
H05BX01
ATC
cinacalcet; oral
72.9
6.5
7
*
V03AE03
ATC
lanthanum carbonate; oral
72.9
6.5
7
*
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
72.9
6.5
7
*
N17.8
ICD-10 Finland
Other acute renal failure
72.9
6.5
7
*
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
19.0
6.3
9
5
3AC01, ,
NOMESCO Finland
28.0
6.3
8
*
WW400
NOMESCO Finland
Plasmaferesis
+∞
6.3
6
*
N25.0
ICD-10 Finland
Renal osteodystrophy
+∞
6.3
6
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
+∞
6.3
6
*
L04AA13
ATC
[U] leflunomide
+∞
6.3
6
*
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
+∞
6.3
6
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
+∞
6.3
6
*
J01MA06
ATC
norfloxacin; oral
3.3
6.3
26
90
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.7
6.2
17
33
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.5
6.2
23
74
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
7.2
6.2
14
21
A10AC01
ATC
insulin (human); parenteral
6.1
6.2
16
29
WX892
NOMESCO Finland
Monitored bed care
4.2
6.2
17
44
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
13.3
6.2
10
8
WX002
NOMESCO Finland
Sedation and analgesia
2.9
6.1
32
127
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.1
6.1
29
109
B01AB05
ATC
enoxaparin; parenteral
2.5
6.1
52
265
C09AA05
ATC
ramipril; oral
2.9
6.1
34
140

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
117
48
112.60
184.12
22.2
1.2
36.24
5.62
iu/ml
—
79
9
62
62
16.49
59.18
3.8
3.0
66.21
76.88
e9/l
0.86
32
44
111
245
15.12
58.98
11.1
2.4
2.34
9.99
e6/l
1.62
111
216
71
89
14.41
58.33
5.2
2.7
1.70
1.63
%
0.19
71
84
120
302
16.72
56.63
22.4
3.2
45.49
12.98
mg/mmol
2.45
110
176
118
300
15.47
54.75
18.5
2.8
196.72
72.30
mg/l
3.10
108
183
123
354
15.65
50.07
20.2
4.5
—
—
—
0
0
66
99
11.23
46.45
8.5
4.8
7.36
7.40
ph
3.94
42
52
64
94
11.23
45.72
8.5
4.8
0.26
1.29
mmol/l
1.14
57
79
35
20
22.61
44.28
1.4
1.1
4.23
2.71
u/ml
—
22
7
43
39
15.13
42.68
2.6
1.2
75.35
3.28
u/ml
—
17
5
121
388
12.61
42.62
17.2
2.9
13.65
225.91
e6/l
0.63
114
279
42
39
14.64
41.01
2.7
1.3
30.18
5.64
u/ml
—
18
5
87
225
7.96
36.42
14.6
2.4
477.45
526.54
mosm/kgh2o
1.66
87
190
123
449
11.30
36.40
21.3
3.5
28.97
28.67
e6/l
0.01
117
300
53
80
9.76
36.33
10.1
6.5
—
—
—
0
0
132
520
15.23
36.27
27.1
6.1
1.21
1.22
mmol/l
0.14
122
454
40
43
12.38
35.26
5.7
1.1
14.82
—
iu/ml
—
6
0
101
315
7.95
34.53
16.7
3.2
7.39
7.40
ph
1.16
88
218
36
36
12.89
33.20
2.7
1.2
37.00
35.52
u/ml
—
10
5
102
332
7.67
32.96
18.2
2.9
0.13
0.29
e6/l
2.00
95
221
86
265
6.36
28.56
8.3
3.6
—
—
—
0
0
68
178
6.22
26.77
3.3
1.3
1187.83
350.97
titre
2.80
46
31
74
210
6.05
26.62
12.7
2.7
0.61
0.90
e6/l
0.68
57
100
32
37
10.76
26.44
1.5
1.1
—
—
—
0
0
44
82
7.21
24.33
13.2
5.6
0.04
0.00
%
0.48
24
16
44
84
7.03
23.73
13.9
5.0
0.69
0.90
%
0.19
26
20
43
81
7.07
23.47
12.6
5.0
0.62
0.94
%
0.27
24
18
63
171
5.67
23.40
3.9
3.7
0.81
0.82
mmol/l
0.09
63
163
115
530
6.25
22.15
10.8
3.0
6.32
6.16
ph
0.78
57
297
42
84
6.58
21.49
14.1
5.0
0.00
0.10
%
0.79
24
20
59
162
5.39
21.38
2.6
1.6
—
—
—
0
0
66
200
5.15
21.24
14.6
2.7
0.93
3.13
e6/l
2.02
50
91
27
12
27.15
19.92
2.3
1.8
—
—
—
0
0
112
538
5.45
19.55
33.2
9.4
0.00
0.01
e9/l
0.44
106
415
125
662
6.72
19.19
13.8
3.2
0.00
0.00
estimate
-0.00
31
127
125
663
6.70
19.12
13.8
3.2
0.00
0.00
estimate
-0.00
31
124
125
671
6.55
18.61
13.9
3.3
0.00
0.00
estimate
-0.00
31
118
21
5
48.55
17.81
3.0
2.0
2224.62
633.80
mg
—
21
5
31
55
6.86
17.64
1.5
3.7
—
—
—
0
0
26
42
7.30
16.07
1.4
1.7
—
—
—
0
0
81
344
3.99
15.68
4.1
2.5
—
—
—
0
0
45
125
4.74
15.58
2.2
1.6
1182.83
1113.75
nmol/l
0.20
38
96
23
14
19.18
15.35
2.8
3.4
1.86
1.10
g/24h
—
18
9
26
22
14.07
15.30
1.4
1.6
—
—
—
0
0
68
264
3.92
14.85
3.2
1.9
2.76
2.65
mg/l
0.18
62
224
24
18
15.65
14.83
1.4
2.3
278.00
164.70
u/ml
—
18
10
24
41
6.79
14.02
8.5
4.1
—
—
—
0
0
67
267
3.76
13.92
2.7
1.7
—
—
—
0
0
66
263
3.72
13.67
2.2
1.6
18.05
20.23
nmol/l
0.77
61
229
78
351
3.58
13.31
17.7
5.9
—
—
—
0
0
90
449
3.56
12.93
20.5
9.2
1.27
1.14
inr
1.21
82
355
48
160
3.96
12.81
3.3
1.9
—
—
—
0
0
28
61
5.43
12.74
8.8
5.0
118.29
127.30
g/l
1.02
28
56
42
130
4.11
12.39
5.2
3.5
3.87
6.35
e9/l
0.54
42
121
68
291
3.47
12.38
1.9
1.4
2.33
2.26
g/l
0.14
47
190
41
125
4.15
12.35
9.1
6.4
103.83
104.37
mmol/l
0.28
41
125
21
18
13.38
12.28
11.0
3.0
14.95
8.03
pmol/l
1.18
21
18
11
0
+∞
11.61
1.0
0.0
32.38
—
u/ml
—
5
0
41
131
3.95
11.51
3.1
1.6
—
—
—
0
0
22
24
10.56
11.48
6.4
2.7
63.95
62.02
%
0.22
22
24
15
6
27.57
11.39
1.3
1.0
—
—
—
0
0
27
63
5.02
11.32
9.2
8.9
22.99
24.23
mmol/l
0.85
27
63
22
43
5.83
11.18
1.3
1.1
—
—
—
0
0
35
102
4.18
11.12
5.6
2.0
0.00
0.00
estimate
—
6
17
18
16
12.63
10.38
6.8
2.3
4.12
5.93
e9/l
1.27
18
16
83
452
2.90
9.29
2.6
1.9
105.15
97.96
pmol/l
0.75
48
245
19
24
8.91
9.19
1.4
5.5
1.42
2.25
ratio
—
9
13
68
337
2.88
9.03
2.7
2.1
—
—
—
0
0
15
13
12.68
8.79
2.0
1.2
—
—
—
0
0
12
6
21.59
8.62
2.9
10.2
84.67
76.50
%
—
12
6
12
6
21.59
8.62
2.7
10.2
8.67
11.50
%
—
12
6
15
14
11.77
8.51
2.3
1.2
—
—
—
0
0
32
106
3.58
8.35
2.0
1.5
—
—
—
0
0
19
29
7.35
8.21
4.6
2.9
2.50
2.40
index
—
8
15
19
43
4.92
8.16
2.7
2.5
8.71
8.58
kpa
0.10
19
43
68
353
2.71
8.06
13.7
3.2
0.00
0.00
estimate
-0.00
25
116
12
8
16.17
7.86
2.2
8.6
47.67
38.09
%
—
12
8
16
20
8.82
7.83
10.5
10.9
63.49
69.20
%
0.43
16
20
73
403
2.60
7.52
3.3
2.4
—
—
—
0
0
7
0
+∞
7.35
21.7
0.0
5.41
—
mmol/l
—
7
0
10
5
21.29
7.23
1.3
1.4
—
—
—
0
0
15
20
8.21
7.10
7.1
2.3
7.40
7.42
ph
1.07
15
20
20
54
4.13
6.90
10.9
5.2
0.67
0.64
%
0.11
20
54
60
312
2.55
6.87
23.7
3.4
—
—
—
0
0
14
18
8.46
6.79
11.9
10.9
69.25
67.17
%
0.13
14
18
20
55
4.05
6.74
10.5
5.1
0.91
1.39
%
1.23
20
55
12
12
10.76
6.67
2.0
1.1
—
—
—
0
0
70
402
2.41
6.36
4.7
3.0
51.88
29.29
ng/l
0.51
55
221
10
8
13.29
6.18
1.0
1.0
—
—
—
0
0
38
165
2.75
6.17
1.7
1.4
140.23
66.17
ug/g
0.89
30
126
17
36
5.20
5.83
5.9
2.4
21.69
24.63
mmol/l
1.94
17
36
12
16
8.05
5.76
1.0
1.4
—
—
—
0
0
9
7
13.58
5.66
3.9
6.3
—
—
—
0
0
11
14
8.39
5.45
1.3
1.1
—
—
—
0
0
11
14
8.39
5.45
1.3
1.1
—
—
—
0
0
11
14
8.39
5.45
1.3
1.1
—
—
—
0
0
11
14
8.39
5.45
1.3
1.1
—
—
—
0
0
12
18
7.15
5.37
8.4
2.1
—
—
—
0
0
35
156
2.63
5.36
1.9
1.3
—
—
—
0
0
15
31
5.26
5.29
1.6
1.3
—
—
—
0
0
9
9
10.55
5.10
2.0
2.6
1504.56
2327.78
ml
—
9
9
53
292
2.27
5.08
2.1
1.9
2.16
0.96
mg/l
1.09
47
228
9
10
9.49
4.85
1.6
1.2
33.44
33.20
pg
—
9
10
88
602
2.14
4.81
3.9
2.7
—
—
estimate
—
0
0
25
100
2.80
4.68
1.5
1.5
—
—
—
0
0
10
15
7.06
4.55
4.1
12.8
10.77
11.85
%
—
10
15
10
16
6.61
4.37
1.3
1.1
—
—
—
0
0
10
17
6.22
4.21
1.1
3.7
—
—
—
0
0
9
14
6.76
4.05
8.4
1.7
4.50
4.92
kpa
—
9
14
9
14
6.76
4.05
8.4
1.7
8.98
9.21
kpa
—
9
14
10
19
5.56
3.90
3.1
2.2
15.53
16.03
%
—
10
19
9
15
6.31
3.88
1.0
1.2
—
—
—
0
0
6
5
12.42
3.79
2.0
3.0
0.55
0.90
e9/l
—
6
5
6
5
12.42
3.79
1.7
2.0
7.24
60.20
umol/l
—
6
5
74
509
1.91
3.64
14.7
3.0
0.00
0.01
estimate
0.50
26
107
22
94
2.57
3.62
7.7
6.0
7.41
7.41
ph
—
7
51
7
9
8.09
3.60
1.3
2.1
—
—
—
0
0
6
6
10.35
3.53
7.8
3.7
0.33
0.83
index
—
6
6
142
1281
3.67
3.41
60.2
11.2
15.94
21.78
mg/l
2.23
134
990
52
324
1.93
3.40
1.4
1.3
1.13
1.15
u/ml
0.01
12
80
7
10
7.28
3.40
1.1
1.3
—
—
—
0
0
22
98
2.46
3.32
25.9
3.2
—
—
—
0
0
5
5
10.28
3.00
3.0
11.2
46.20
30.00
%
—
5
5
5
5
10.28
3.00
1.0
1.0
986.92
1428.60
miu/ml
—
5
5
13
47
2.94
2.90
2.8
2.0
—
—
—
0
0
12
39
3.26
2.85
5.0
2.7
1.23
1.48
%
0.63
12
31
5
6
8.57
2.77
1.0
1.0
134.80
197.67
mmol/24h
—
5
6
12
43
2.95
2.72
3.9
3.5
25.83
20.22
s
0.64
12
36
73
536
1.71
2.64
2.1
1.9
—
—
—
0
0
11
36
3.22
2.63
5.4
2.9
0.75
0.81
%
0.24
11
28
56
384
1.74
2.58
13.8
2.6
0.00
0.01
estimate
0.50
26
99
10
31
3.38
2.57
3.6
1.9
—
—
—
0
0
9
26
3.62
2.53
1.2
1.1
—
—
—
0
0
5
8
6.42
2.39
1.8
1.0
—
—
—
0
0
5
8
6.42
2.39
1.6
1.3
—
—
—
0
0
5
8
6.42
2.39
1.8
1.0
—
—
—
0
0
5
8
6.42
2.39
1.8
1.5
—
—
—
0
0
13
53
2.59
2.35
7.5
7.7
0.65
0.73
%
0.25
13
53
13
54
2.54
2.27
6.9
7.7
1.14
1.64
%
1.13
13
54
5
9
5.70
2.23
1.0
1.0
—
—
—
0
0
44
293
1.71
2.21
10.7
3.1
1.02
1.02
kg/l
0.48
38
180
11
42
2.75
2.19
1.4
1.1
—
—
—
0
0
42
593
0.59
2.15
4.4
2.5
—
—
—
0
0
8
25
3.32
2.13
2.0
2.7
3.52
3.76
mmol/l
—
8
25
0
57
0.00
2.10
0.0
1.2
—
—
—
0
0
5
10
5.13
2.08
1.4
1.2
—
—
—
0
0
28
166
1.85
2.06
1.4
1.1
—
—
—
0
0
9
33
2.84
1.97
2.4
2.7
—
—
—
0
0
8
28
2.96
1.89
1.8
2.5
—
—
—
0
0
16
82
2.07
1.77
1.4
1.2
—
—
—
0
0
6
19
3.25
1.68
1.2
1.1
—
—
—
0
0
7
25
2.89
1.67
12.4
3.2
—
—
—
0
0
18
100
1.91
1.61
1.3
1.3
124.99
199.10
u/ml
0.25
13
91
19
108
1.87
1.60
1.3
1.2
—
—
—
0
0
6
20
3.08
1.60
1.0
1.2
—
—
—
0
0
6
20
3.08
1.60
1.2
1.1
—
—
—
0
0
114
1004
1.59
1.56
5.9
3.2
14.45
14.31
pmol/l
0.25
104
937
5
15
3.41
1.53
4.0
1.9
—
—
—
0
0
5
15
3.41
1.53
1.0
1.1
85.72
24.03
mu/l
—
5
15
10
47
2.21
1.37
5.1
1.8
—
—
—
0
0
5
17
3.01
1.37
1.2
1.5
12.60
19.04
ng/l
—
5
17
10
186
0.50
1.28
1.4
1.4
—
—
—
0
0
8
39
2.11
1.17
7.0
3.7
36.89
36.94
°c
—
8
39
123
1126
1.55
1.17
64.3
13.8
13.90
13.38
%
5.09
123
1119
130
1205
1.65
1.17
6.5
4.0
1.87
1.75
mu/l
0.61
125
1136
20
128
1.65
1.16
1.3
1.2
—
—
—
0
0
7
30
2.40
1.14
2.4
2.3
0.57
239.59
e6/l
—
7
22
16
100
1.67
1.01
1.6
4.7
3.23
15.36
ug/l
1.66
11
81
0
31
0.00
0.97
0.0
1.0
—
0.34
—
0
13
5
102
0.47
0.93
1.2
1.2
—
—
—
0
0
17
111
1.60
0.92
3.2
2.0
5.82
6.08
ph
0.80
11
71
8
43
1.91
0.89
1.5
1.1
—
—
—
0
0
0
25
0.00
0.80
0.0
1.0
—
1.65
—
0
12
5
28
1.81
0.67
3.0
3.6
22.00
18.36
mg/l
—
5
19
19
139
1.42
0.64
1.5
1.4
—
—
—
0
0
27
211
1.34
0.63
2.0
1.7
—
—
—
0
0
0
22
0.00
0.60
0.0
1.0
—
1.16
—
0
8
31
252
1.29
0.56
1.3
1.3
1.30
2.31
u/ml
0.42
14
99
11
76
1.48
0.49
1.5
1.2
—
39.00
—
0
5
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
12
91
1.35
0.35
2.7
2.1
—
8.50
—
0
7
6
47
1.29
0.32
2.0
1.6
—
—
—
0
0
6
47
1.29
0.32
4.3
3.4
—
—
—
0
0
138
1351
1.32
0.29
39.3
9.8
—
—
—
0
0
31
273
1.17
0.28
1.5
1.3
13.22
20.48
iu/ml
0.71
11
80
5
42
1.20
0.21
1.0
3.2
74.00
4277.31
u/ml
—
5
35
0
11
0.00
0.21
0.0
4.2
—
51.44
—
0
11
0
11
0.00
0.21
0.0
1.0
—
251.00
—
0
5
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
26.0
—
1646.38
—
0
13
0
13
0.00
0.21
0.0
18.7
—
1023.92
—
0
13
126
1232
1.15
0.20
6.3
4.1
5.29
5.68
mmol/l
7.49
121
1152
5
67
0.74
0.17
1.0
1.1
0.78
0.90
g/l
—
5
67
5
67
0.74
0.17
1.0
1.1
1.66
1.57
g/l
—
5
67
5
67
0.74
0.17
1.0
1.1
—
0.71
—
0
9
5
69
0.72
0.17
2.2
1.6
—
—
—
0
0
6
79
0.75
0.16
2.0
1.5
—
—
—
0
0
19
172
1.12
0.12
1.4
1.9
—
—
—
0
0
114
1158
0.93
0.09
57.9
13.9
329.04
332.60
g/l
4.54
114
1150
7
82
0.85
0.07
1.1
1.1
—
—
—
0
0
9
85
1.06
0.07
1.7
1.5
—
—
—
0
0
9
87
1.04
0.07
1.7
1.5
—
—
—
0
0
21
220
0.95
0.04
1.5
1.6
—
—
—
0
0
17
178
0.95
0.02
1.4
1.2
—
—
—
0
0
43
423
1.02
0.01
1.8
1.6
—
—
—
0
0
8
87
0.91
-0.00
1.8
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
56.25
—
0
8
0
5
0.00
-0.00
0.0
3.2
—
114.20
—
0
5
6
65
0.92
-0.00
1.8
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
10.50
—
0
6
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
5
55
0.91
-0.00
1.2
1.7
—
5.48
—
0
13
5
56
0.89
-0.00
1.2
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
5.61
—
0
8
0
6
0.00
-0.00
0.0
3.2
—
—
—
0
0
8
86
0.93
-0.00
1.8
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
6.1
—
0.62
—
0
7
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
0.00
—
0
6

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: M13_LUPUS_NEPHRITIS – Lupus nephritis

GWS hits: 2

This endpoint is excluded (different definition than used in FinnGen).