Tracheo-bronchomalasia

TRACHEOBRONCHOMAL

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 J39.8
  • Cause of death: ICD-10 J39.8

2 out of 7 registries used, show all original rules.

204

4. Check minimum number of events

None

204

5. Include endpoints

None

204

6. Filter based on genotype QC (FinnGen only)

193

Control definitions (FinnGen only)

Control exclude
ASTHMA_COMORB

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J39
Name in latin
Alii morbi tractus respiratorii superioris specificati

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 959 617 340
Only index persons 905 596 309
Unadjusted period prevalence (%)
Whole population 0.01 0.02 0.01
Only index persons 0.02 0.02 0.01
Median age at first event (years)
Whole population 49.42 48.58 51.04
Only index persons 49.18 48.54 50.40

-FinnGen-

Key figures

All Female Male
Number of individuals 193 140 53
Unadjusted period prevalence (%) 0.04 0.05 0.02
Median age at first event (years) 52.64 51.11 56.68

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
196
Matched controls
1960
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J39.8
ICD-10 Finland
Other specified diseases of upper respiratory tract
+∞
283.7
196
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
80.9
198.4
118
36
XG474
NOMESCO Finland
Exhalation nntrogen oxide
54.9
102.7
61
16
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
40.9
74.2
47
15
J45.9
ICD-10 Finland
Asthma, unspecified
12.9
71.5
95
133
R03AK08
ATC
formoterol and beclometasone; inhalant
19.1
53.7
46
31
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
21.3
51.2
41
24
XQ800
NOMESCO Finland
Prick test
12.7
46.0
51
53
J45.1
ICD-10 Finland
Nonallergic asthma
13.8
41.2
42
38
R03BA08
ATC
ciclesonide; inhalant
10.0
39.9
53
70
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.5
38.6
110
323
R06.0
ICD-10 Finland
Dyspnoea
6.5
35.9
83
199
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
+∞
35.5
33
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
7.9
34.2
56
94
G47.3
ICD-10 Finland
Sleep apnoea
7.1
33.9
64
125
R03AC02
ATC
salbutamol; inhalant
8.2
33.0
164
756
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
5.9
27.9
65
153
A02BC05
ATC
esomeprazole; systemic
5.0
27.8
110
402
J45
ICD-10 Finland
Asthma
7.2
27.5
48
85
H02AB06
ATC
prednisolone; systemic
5.0
27.4
121
480
C07AB07
ATC
bisoprolol; oral
5.0
26.7
88
277
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.7
26.1
62
148
R49.01
ICD-10 Finland
Functional dysphonia
25.6
25.9
36
17
R5140
NOMESCO Finland
Monitoring the use of the aid
8.8
25.5
35
47
A02BC02
ATC
pantoprazole; systemic
6.0
25.4
158
803
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
8.2
25.1
37
54
R05
ICD-10 Finland
Cough
4.8
24.8
81
251
J39.9
ICD-10 Finland
Disease of upper respiratory tract, unspecified
142.4
24.2
25
*
SPAT1262
SPAT
Handing over of treatment supplies
9.8
23.4
29
34
R01AD12
ATC
fluticasone furoate; nasal
4.4
23.3
115
481
F32.9
ICD-10 Finland
Depressive episode, unspecified
10.6
23.2
27
29
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
8.8
22.8
31
41
R03DC03
ATC
montelukast; oral
4.9
22.5
65
181
R03BB04
ATC
tiotropium bromide; inhalant
8.9
22.3
30
39
UDH02
NOMESCO Finland
Rhinopharyngoscopy
8.6
22.3
31
42
215
Kela drug reimbursment
Diabetes, non-insulin-treated
+∞
21.2
20
*
103
Kela drug reimbursment
Diabetes, insulin-treated
+∞
21.2
20
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
86.1
21.2
23
*
Z01.9
ICD-10 Finland
Special examination, unspecified
8.2
19.6
28
39
N06AX16
ATC
venlafaxine; oral
6.1
19.0
37
72
N03AX16
ATC
[U] pregabalin
4.5
18.8
58
168
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
49.3
18.7
22
5
Z01.8
ICD-10 Finland
Other specified special examinations
4.3
18.6
61
185
UDC00
NOMESCO Finland
Ear microscopy
7.0
18.2
30
49
SPAT1249
SPAT
Treatment-related counselling outside office
3.7
18.1
97
412
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.9
17.8
26
37
SPAT1263
SPAT
Sampling
3.6
17.6
96
411
UJF32
NOMESCO Finland
Coloscopy
4.4
17.1
52
148
R03BA05
ATC
fluticasone; inhalant
3.9
16.7
63
210
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
3.8
16.6
67
234
SPAT1301
SPAT
No procedures
3.7
16.3
71
260
ZXE00
NOMESCO Finland
One hour or less
3.4
16.3
98
441
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
14.7
16.2
27
21
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
24.6
15.9
22
10
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
15.8
15
*
E66.01
ICD-10 Finland
Obesity due to excess calories
7.2
15.8
25
39
WX780
NOMESCO Finland
Remote monitoring CPAP
14.8
15.7
26
20
N06AA09
ATC
amitriptyline; systemic
6.8
15.6
26
43
WX723
NOMESCO Finland
CPAP therapy
14.1
15.4
26
21
I48
ICD-10 Finland
Atrial fibrillation and flutter
61.7
15.0
17
*
J38.3
ICD-10 Finland
Other diseases of vocal cords
86.8
14.8
16
*
207
Kela drug reimbursment
Chronic arrhythmias
86.8
14.8
16
*
R01AD08
ATC
fluticasone; nasal
3.3
14.8
84
361
UKC02
NOMESCO Finland
Cystoscopy
5.2
14.6
33
73
XX3DW
NOMESCO Finland
Time consuming IT work
4.7
14.6
38
95
J37.0
ICD-10 Finland
Chronic laryngitis
24.6
14.5
20
9
R51.80
ICD-10 Finland
Headache
4.0
14.3
49
151
WX402
NOMESCO Finland
General anaesthesia
3.5
14.2
63
231
K21
ICD-10 Finland
Gastro-oesophageal reflux disease
6.0
14.2
27
51
XKD00
NOMESCO Finland
Uroflowmetry
5.6
14.1
29
59
N06AX21
ATC
duloxetine; oral
5.4
14.1
30
63
R03AK06
ATC
salmeterol and fluticasone; inhalant
4.4
13.9
40
108
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
5.1
13.9
32
72
AA1AD
NOMESCO Finland
CT of head and brain
4.0
13.8
46
139
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
3.9
13.6
49
156
R01AD58
ATC
fluticasone, combinations; nasal
3.2
13.6
79
341
N03AX12
ATC
[U] gabapentin; oral
4.4
13.6
39
105
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
16.6
13.4
21
14
WZC30
NOMESCO Finland
Teaching
4.1
13.4
42
121
N06AX11
ATC
mirtazapine; oral
3.3
13.4
71
290
SPAT1058
SPAT
PEF monitoring instruction
6.5
13.4
23
39
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
30.8
13.2
17
6
R06.5
ICD-10 Finland
Mouth breathing
15.5
13.1
21
15
M54.5
ICD-10 Finland
Low back pain
3.1
12.9
85
392
N02AJ06
ATC
codeine and paracetamol; systemic
3.0
12.8
97
483
GX1L5
NOMESCO Finland
Exhaled nitric oxide analysis
34.6
12.8
16
5
R03AK07
ATC
formoterol and budesonide; inhalant
3.3
12.8
64
252
T90
ICPC
Diabetes non-insulin dependent
12.9
12.7
22
19
R06AE09
ATC
levocetirizine; oral
3.8
12.7
46
147
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
12.6
12
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.7
12.6
25
49
A10BA02
ATC
metformin; oral
15.7
12.6
20
14
J01FA09
ATC
clarithromycin; systemic
3.0
12.5
83
384
A02BC03
ATC
lansoprazole; oral
3.3
12.4
62
243
J31.0
ICD-10 Finland
Chronic rhinitis
4.6
12.4
32
79
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
23.1
12.2
17
8
R06AE07
ATC
cetirizine; oral
2.9
12.2
110
599
R10.1
ICD-10 Finland
Pain localized to upper abdomen
3.5
12.2
51
179
F51.0
ICD-10 Finland
Nonorganic insomnia
3.4
12.1
54
197
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.9
11.9
84
399
R07.4
ICD-10 Finland
Chest pain, unspecified
3.5
11.9
51
181
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
32.3
11.8
15
5
R03BA01
ATC
beclometasone; inhalant
3.8
11.8
42
132
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
4.8
11.7
29
69
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
3.0
11.7
134
822
J01.0
ICD-10 Finland
Acute maxillary sinusitis
3.0
11.4
71
314
N06AB04
ATC
citalopram; systemic
4.2
11.4
34
94
J45.0
ICD-10 Finland
Predominantly allergic asthma
4.5
11.2
30
76
SPAT1312
SPAT
General health counselling
2.9
11.2
75
345
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.9
11.1
21
39
M01AE02
ATC
naproxen; oral, rectal
2.9
11.1
136
854
R49.8
ICD-10 Finland
Other and unspecified voice disturbances
46.1
11.1
13
*
XF404
NOMESCO Finland
Ambulatory ECG
9.4
10.9
22
26
N05BA04
ATC
oxazepam; oral
3.3
10.9
51
191
J02AC01
ATC
fluconazole; systemic
2.7
10.9
102
557
R23
ICPC
Voice symptom/complaint
11.0
10.8
20
20
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
4.4
10.7
29
74
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.3
10.7
49
181
A10BK03
ATC
empagliflozin; oral
116.0
10.5
11
*
J01AA02
ATC
doxycycline; systemic
3.5
10.5
163
1149
C01DA14
ATC
isosorbide mononitrate; oral
34.6
10.5
13
*
XKC03
NOMESCO Finland
Water cystometry
25.0
10.4
14
6
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
3.6
10.4
40
132
A02BC01
ATC
omeprazole; systemic
3.0
10.4
61
260
SCA03
NOMESCO Finland
Preventive oral health care, extensive
5.7
10.3
20
38
N02AX02
ATC
tramadol; systemic, rectal
2.7
10.3
81
402
R42
ICD-10 Finland
Dizziness and giddiness
3.3
10.3
45
161
C07AB02
ATC
metoprolol; systemic
4.6
10.3
26
63
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.7
10.1
85
436
J01DB01
ATC
cefalexin; oral
4.0
10.1
173
1277
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.0
10.1
23
51
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
5.1
10.0
22
47
J46
ICD-10 Finland
Status asthmaticus
27.7
9.9
13
5
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.6
9.9
93
502
J01FA10
ATC
azithromycin; systemic
2.8
9.8
137
895
G44.2
ICD-10 Finland
Tension-type headache
3.5
9.7
37
121
G04BD12
ATC
mirabegron; oral
4.7
9.7
24
57
R02
ICPC
Shortness of breath/dyspnoea
4.4
9.7
26
66
J01DA01
ATC
[U] cefalexin
2.7
9.6
131
842
SPAT1153
SPAT
Removal of sutures
2.8
9.6
61
270
L04AX03
ATC
methotrexate; systemic
5.6
9.6
19
37
E11
ICD-10 Finland
Type 2 diabetes mellitus
18.7
9.5
14
8
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
104.9
9.5
10
*
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
104.9
9.5
10
*
R03AC13
ATC
formoterol; inhalant
10.3
9.5
18
19
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
23.1
9.5
13
6
ZXE10
NOMESCO Finland
More than one and less than three hours
2.7
9.4
73
357
R06AX27
ATC
desloratadine; oral
2.6
9.3
80
412
H03AA01
ATC
levothyroxine sodium; systemic
2.9
9.3
55
234
N02BF01
ATC
gabapentin; oral
4.1
9.3
27
73
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
10.8
9.2
17
17
R49.08
ICD-10 Finland
Other specified dysphonia
16.6
9.2
14
9
J01MA02
ATC
ciprofloxacin; systemic
2.6
8.9
70
344
M79.6
ICD-10 Finland
Pain in limb
2.5
8.8
93
524
J38.7
ICD-10 Finland
Other diseases of larynx
52.4
8.8
10
*
N06AB03
ATC
fluoxetine; oral
4.5
8.7
22
53
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.7
8.6
30
92
N05AH04
ATC
quetiapine; oral
3.9
8.6
27
77
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
13.6
8.5
14
11
SPAT1130
SPAT
Esophagoscopy, gastroscopy and duodenoscopy
13.6
8.5
14
11
R01AD09
ATC
mometasone; nasal
2.4
8.5
109
668
H25.1
ICD-10 Finland
Senile nuclear cataract
10.1
8.5
16
17
OAB50, ,
SPAT
11.5
8.5
15
14
AN1
HP
Coronary angiography
+∞
8.4
8
*
A10BH01
ATC
sitagliptin; oral
+∞
8.4
8
*
I50.9
ICD-10 Finland
Heart failure, unspecified
15.4
8.3
13
9
SPAT1254
SPAT
Administration of medicine
4.0
8.3
25
69
HMAK, ,
NOMESCO Finland
3.2
8.3
38
139
WZC00
NOMESCO Finland
Treatment plan or consultation
2.4
8.3
81
438
R01AD01
ATC
beclometasone; nasal
2.9
8.2
45
182
D82
ICPC
Teeth/gum disease
2.4
8.2
93
536
A01AB04
ATC
amphotericin B; local oral
9.6
8.2
16
18
R51
ICD-10 Finland
Headache
4.6
8.2
20
47
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
4.6
8.2
20
47
UJF30
NOMESCO Finland
Ileoscopy through colon
4.6
8.2
20
47
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
4.6
8.2
20
47
B01AA03
ATC
warfarin; systemic
7.1
8.1
19
29
N02BF02
ATC
pregabalin; oral
4.8
8.1
19
43
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
5.0
8.1
18
39
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
3.3
8.0
33
113
J01FF01
ATC
clindamycin; systemic
2.6
8.0
56
258
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
10.0
7.9
15
16
M03BC51
ATC
orphenadrine, combinations; systemic
2.5
7.9
65
323
J01MA12
ATC
levofloxacin; systemic
3.1
7.9
36
131
A01AB09
ATC
miconazole; local oral
4.7
7.9
19
44
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
4.7
7.9
19
44
SPAT1310
SPAT
Counselling related to known health issue
2.5
7.8
62
303
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
7.2
7.8
18
27
R03BA02
ATC
budesonide; inhalant
2.8
7.8
44
181
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
46.9
7.8
9
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
46.9
7.8
9
*
P01AB01
ATC
metronidazole; oral, rectal
2.3
7.8
88
505
N02BE01
ATC
paracetamol; systemic, rectal
3.7
7.7
177
1398
J01FA06
ATC
roxithromycin; oral
2.4
7.7
82
457
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.4
7.7
82
457
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.0
7.7
23
63
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.6
7.7
56
262
N06AB10
ATC
escitalopram; oral
2.9
7.7
40
157
R49.09
ICD-10 Finland
Unspecified dysphonia
19.3
7.7
11
6
R49.0
ICD-10 Finland
Dysphonia
10.7
7.7
14
14
B01AF02
ATC
apixaban; oral
10.7
7.7
14
14
WZC00, ,
SPAT
3.2
7.7
33
116
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.2
7.7
33
116
M54.4
ICD-10 Finland
Lumbago with sciatica
2.9
7.6
42
170
J32.4
ICD-10 Finland
Chronic pansinusitis
26.2
7.6
10
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.7
7.6
18
41
R53
ICD-10 Finland
Malaise and fatigue
2.6
7.5
53
244
M01AE03
ATC
ketoprofen; systemic, rectal
2.4
7.4
74
400
SPAT1377
SPAT
Polysomnography
10.0
7.4
14
15
R06.2
ICD-10 Finland
Wheezing
7.8
7.4
16
22
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
+∞
7.3
7
*
H26.4
ICD-10 Finland
After-cataract
+∞
7.3
7
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.3
7.3
82
466
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.8
7.3
40
162
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
12.7
7.2
12
10
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
9.3
7.2
14
16
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.1
7.1
33
121
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.0
7.1
34
127
ZYC01, ,
SPAT
3.3
7.1
28
93
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
3.9
7.1
22
62
A06AC01
ATC
ispaghula (psylla seeds); oral
2.6
7.1
50
230
C08CA01
ATC
amlodipine; oral
2.5
7.1
52
244
JN3AD
NOMESCO Finland
Abdominal CT examination
3.4
7.1
27
88
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
4.1
7.0
20
53
R4110, ,
SPAT
3.1
7.0
31
111
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
6.5
6.9
17
28
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
3.7
6.9
23
68
I10
ICD-10 Finland
Essential (primary) hypertension
2.2
6.9
86
507
M03BX02
ATC
tizanidine; oral
2.3
6.9
136
967
M03BC01
ATC
orphenadrine (citrate); systemic
2.5
6.9
51
240
M01AC06
ATC
meloxicam; systemic, rectal
2.3
6.8
74
412
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
5.9
6.8
18
33
M01AH05
ATC
etoricoxib; oral
2.3
6.8
135
960
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.2
6.7
113
749
I47.1
ICD-10 Finland
Supraventricular tachycardia
23.5
6.7
9
*
E66.00
ICD-10 Finland
Metabolic syndrome
12.9
6.7
11
9
Z20.2
ICD-10 Finland
Contact with and exposure to infections with a predominantly sexual mode of transmission
9.2
6.7
13
15
SPAT1260
SPAT
Consultation of another employee
3.0
6.6
32
120
N06AX26
ATC
vortioxetine; oral
6.6
6.6
16
26
M79.1
ICD-10 Finland
Myalgia
2.8
6.6
38
157
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
3.5
6.5
23
71
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.9
6.5
20
56
M54.6
ICD-10 Finland
Pain in thoracic spine
3.6
6.5
22
66
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.9
6.5
17
31
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
15.0
6.5
10
7
N05AX12
ATC
aripiprazole; systemic
72.1
6.5
7
*
TFP20
NOMESCO Finland
Cardiodefibrillation
72.1
6.5
7
*
EMAK, ,
NOMESCO Finland
6.4
6.5
16
27
R03AC12
ATC
salmeterol; inhalant
6.4
6.5
16
27
-1, ,
ICD-10 Finland
3.9
6.4
19
52
A07AA02
ATC
nystatin; oral
7.4
6.3
14
20
XKD03
NOMESCO Finland
Urethral pressure profilometry
18.8
6.3
9
5
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
4.2
6.3
17
43
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
6.3
51
249
R13
ICD-10 Finland
Dysphagia
6.1
6.3
16
28
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
+∞
6.3
6
*
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
+∞
6.3
6
*
A10BJ06
ATC
semaglutide; parenteral
+∞
6.3
6
*
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
6.3
6
*
OAB72
NOMESCO Finland
Weight control and weight loss guidance
+∞
6.3
6
*
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
+∞
6.3
6
*
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
+∞
6.3
6
*
SPAT1238
SPAT
Brief therapy
27.6
6.3
8
*
R33
ICD-10 Finland
Retention of urine
27.6
6.3
8
*
A02BA02
ATC
ranitidine; systemic
2.9
6.3
32
124
R00.2
ICD-10 Finland
Palpitations
3.4
6.2
23
73
WZA00
NOMESCO Finland
Concise certificate
3.7
6.2
20
58
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
2.8
6.2
33
131
N30.9
ICD-10 Finland
Cystitis, unspecified
4.1
6.1
17
44
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.1
6.1
17
44
SCA02
NOMESCO Finland
Preventive oral health care
2.8
6.1
32
126
R07.3
ICD-10 Finland
Other chest pain
3.7
6.0
20
59
R35
ICD-10 Finland
Polyuria
5.4
6.0
17
34
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
4.3
6.0
16
40
M01AB05
ATC
diclofenac; systemic, rectal
2.2
6.0
135
985

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
65
74
12.65
55.65
3.1
3.1
1.23
1.24
mmol/l
0.46
56
61
74
107
10.50
52.86
3.9
3.0
—
—
—
0
0
127
341
8.74
51.83
5.7
3.1
—
—
—
0
0
35
20
21.09
43.91
2.9
2.3
—
—
—
0
0
153
604
7.99
38.68
16.0
7.5
0.00
0.00
e9/l
0.57
146
495
110
354
5.80
33.89
5.0
5.4
—
—
—
0
0
53
85
8.18
33.66
4.8
4.2
0.18
0.13
%
0.10
11
16
115
392
5.68
32.89
4.5
2.7
0.00
0.01
estimate
0.50
77
146
52
86
7.87
32.05
4.1
3.5
1.00
0.94
%
0.02
11
18
52
86
7.87
32.05
4.9
3.5
0.27
0.00
%
0.72
11
16
113
393
5.43
31.18
12.3
3.0
1.15
1.03
inr
2.03
105
312
73
175
6.05
31.05
2.0
1.4
415.83
56522171.60
pmol/l
0.50
54
161
52
90
7.50
30.67
4.9
3.5
0.91
1.10
%
0.11
11
20
105
355
5.22
29.69
4.5
1.7
13.55
14.20
ng/l
0.10
59
157
68
164
5.82
28.49
1.6
1.4
—
—
—
0
0
145
660
5.60
27.64
6.3
4.8
0.18
0.19
e9/l
0.45
138
579
128
559
4.72
24.87
6.5
5.0
2.79
3.01
%
0.52
121
523
136
623
4.86
24.75
6.5
4.8
0.53
0.51
e9/l
0.76
128
545
128
561
4.69
24.70
6.5
5.0
8.47
8.54
%
0.13
121
527
31
11
33.13
24.02
2.1
3.6
3.63
4.40
e9/l
0.81
31
11
126
558
4.52
23.67
6.6
5.0
0.78
0.71
%
0.95
119
521
137
645
4.73
23.67
6.5
4.8
1.97
1.86
e9/l
1.17
130
575
134
626
4.61
23.26
6.5
4.8
0.04
0.04
e9/l
0.32
127
544
128
590
4.37
22.34
6.6
4.8
30.85
30.25
%
0.29
122
563
31
18
20.20
20.83
2.0
2.7
55.61
59.39
%
0.53
31
18
106
450
3.95
20.31
4.4
2.1
0.01
0.03
estimate
0.26
67
120
57
155
4.78
20.12
1.4
1.3
166.67
752.00
titre
—
6
25
122
584
3.88
19.24
4.8
2.5
0.09
0.02
estimate
0.55
67
122
80
289
3.99
19.21
3.1
3.3
7.40
7.40
ph
0.50
65
197
126
629
3.81
18.37
3.3
3.0
6.02
5.92
mmol/l
0.37
120
577
26
14
21.18
17.89
2.7
3.4
7.41
7.43
ph
0.70
26
14
86
343
3.69
17.58
2.7
2.0
60.75
76.61
u/l
0.52
75
319
98
427
3.59
17.43
3.6
4.1
36.51
37.37
g/l
1.08
85
401
71
252
3.85
17.23
2.5
1.5
116.14
224.32
u/l
1.00
66
236
47
129
4.48
16.15
1.5
1.1
—
—
—
0
0
23
12
21.50
15.99
2.1
2.3
17.60
16.55
%
0.33
23
12
78
314
3.47
15.37
1.4
1.2
0.97
2.06
u/ml
0.46
42
88
134
750
3.49
15.24
4.1
2.6
88.21
86.86
ug/l
0.06
124
720
132
738
3.42
14.92
5.2
2.6
0.00
0.00
estimate
-0.00
78
151
116
604
3.26
14.73
4.6
6.1
8.87
11.58
umol/l
3.11
105
581
70
271
3.46
14.57
2.0
2.4
306.09
306.31
umol/l
0.01
64
251
39
100
4.62
14.52
1.9
1.4
1565.81
1172.13
nmol/l
1.43
27
77
132
746
3.36
14.49
5.2
2.6
0.00
0.00
estimate
-0.00
79
150
133
758
3.35
14.33
8.6
7.9
3.68
3.74
e9/l
0.11
125
662
157
992
3.93
14.26
7.9
5.8
69.85
75.57
u/l
1.63
149
943
20
10
22.07
14.10
1.0
1.1
—
—
—
0
0
19
8
26.10
14.08
2.8
2.9
—
—
—
0
0
25
45
6.22
13.75
3.9
10.0
24.13
24.82
mmol/l
0.55
25
45
131
752
3.24
13.70
5.2
2.7
0.00
0.00
estimate
-0.00
77
149
20
11
20.06
13.69
2.9
4.0
8.67
10.23
kpa
0.72
20
11
20
11
20.06
13.69
2.9
4.0
4.85
4.80
kpa
0.08
20
11
172
1176
4.78
13.45
6.7
3.8
15.08
14.38
pmol/l
3.30
159
1106
65
252
3.36
13.36
2.5
1.9
8.78
7.88
mmol/l
0.61
52
222
91
433
3.06
13.15
4.3
4.5
1.22
1.22
mmol/l
0.61
81
404
17
7
26.40
12.70
1.5
1.1
2.02
1.20
mmol/l
—
17
7
61
235
3.32
12.58
2.6
1.5
3.04
2.47
mg/l
1.48
55
194
57
212
3.38
12.43
2.6
2.0
29.85
92.56
mg/l
1.33
31
98
17
8
23.10
12.24
3.6
3.5
—
—
—
0
0
98
502
2.90
12.16
5.2
5.3
1.22
1.22
mmol/l
0.02
61
434
67
278
3.14
12.16
1.5
1.3
2.20
2.11
g/l
0.19
57
188
56
217
3.21
11.32
3.4
2.2
3.69
15.00
mg/mmol
1.73
28
104
15
6
26.87
11.32
1.6
1.2
91.85
91.63
%
—
15
6
42
137
3.63
11.13
2.8
1.3
104.43
41.55
ug/g
0.83
28
98
40
128
3.67
10.89
1.6
1.3
—
—
—
0
0
17
12
15.37
10.70
2.9
3.9
—
—
—
0
0
63
273
2.93
10.39
2.0
1.6
0.52
0.85
mg/l
0.66
41
209
41
140
3.44
10.08
2.9
2.0
15.93
16.02
umol/l
0.02
36
133
61
264
2.90
10.04
1.4
1.2
1.89
7.17
u/ml
0.84
41
102
125
778
2.67
9.92
3.8
2.4
—
—
—
0
0
63
290
2.73
9.13
1.4
1.2
11.67
21.96
iu/ml
0.91
23
84
181
1409
4.72
9.03
7.5
4.3
1.72
1.81
mu/l
0.56
170
1329
65
307
2.67
8.93
3.6
2.4
0.10
0.44
e6/l
1.45
59
211
16
16
10.77
8.71
1.9
2.6
5.78
6.04
pmol/l
0.08
16
16
96
573
2.32
7.71
4.0
2.4
6.22
6.24
ph
0.08
58
330
127
866
2.33
7.29
5.4
3.3
—
133.30
—
0
10
20
52
4.17
7.18
2.9
2.4
5.17
5.09
kpa
0.19
20
52
22
62
3.87
7.10
1.3
1.2
—
—
—
0
0
12
11
11.53
6.90
2.9
2.2
91.20
92.94
%
0.35
12
11
67
358
2.32
6.81
3.6
2.4
12.58
68.27
e6/l
0.74
59
263
18
35
5.55
6.51
1.6
3.1
—
—
—
0
0
34
134
2.86
6.46
2.1
1.3
—
—
—
0
0
54
270
2.38
6.33
1.8
1.3
21.09
20.61
nmol/l
0.08
46
234
185
1552
4.42
6.32
19.3
7.8
13.89
22.55
mg/l
4.04
166
1099
11
11
10.51
6.11
2.7
1.8
32.36
32.64
pg
0.05
11
11
98
632
2.10
6.08
1.9
1.9
—
—
—
0
0
75
438
2.15
6.02
4.5
2.8
6.70
71.36
e6/l
2.37
65
281
32
128
2.79
5.90
1.4
1.4
—
—
—
0
0
10
9
11.63
5.86
1.1
1.1
—
—
—
0
0
19
56
3.65
5.75
1.5
3.8
68.99
68.80
g/l
0.04
19
56
45
216
2.41
5.74
1.4
1.2
—
—
—
0
0
9
8
11.71
5.34
1.2
1.0
—
—
—
0
0
170
1395
2.65
5.32
5.7
3.0
38.19
35.84
mmol/mol
5.35
154
1330
189
1688
4.35
5.24
18.3
7.4
—
—
—
0
0
13
23
5.97
5.16
2.2
2.1
25.06
24.57
mmol/l
0.16
13
23
45
230
2.24
4.92
6.4
3.4
—
—
—
0
0
141
1087
2.06
4.90
3.5
2.5
38.20
32.98
u/l
0.62
128
1049
174
1462
2.69
4.84
5.3
3.2
5.69
5.40
mmol/l
4.33
159
1382
9
11
8.51
4.61
1.6
1.3
39.78
19.45
ng/l
—
9
11
7
5
14.44
4.61
1.1
3.6
0.85
1.40
ug/l
—
7
5
17
55
3.29
4.48
1.9
2.0
0.00
0.06
estimate
0.48
12
16
7
6
12.03
4.31
1.4
1.5
0.00
0.00
estimate
—
7
6
12
25
5.04
4.26
1.1
1.2
—
—
—
0
0
32
152
2.32
4.13
2.1
1.2
—
—
—
0
0
16
53
3.20
4.07
5.1
5.4
65.33
68.22
e9/l
—
10
43
10
18
5.79
4.03
1.3
3.1
—
—
—
0
0
6
5
12.32
3.78
1.2
1.0
—
—
—
0
0
12
30
4.19
3.66
1.4
2.2
—
—
—
0
0
54
328
1.89
3.64
4.3
2.1
—
—
—
0
0
6
6
10.26
3.52
1.2
1.0
187.83
164.11
mmol/24h
—
6
6
86
607
1.74
3.51
2.2
1.6
1.48
1.24
mmol/l
1.61
58
546
69
463
1.76
3.33
1.8
1.4
90.24
97.91
pmol/l
0.57
33
254
21
93
2.41
3.16
1.4
1.1
—
—
—
0
0
5
5
10.21
2.99
1.8
1.0
283.60
284.40
mosm/kgh2o
—
5
5
13
46
2.96
2.98
1.1
1.4
—
—
—
0
0
34
190
1.96
2.90
1.1
1.6
—
—
—
0
0
7
13
5.54
2.89
1.1
1.1
—
—
—
0
0
11
34
3.37
2.77
1.3
1.0
2.36
7.63
u/ml
—
5
9
5
6
8.51
2.76
2.0
1.0
—
—
—
0
0
5
6
8.51
2.76
1.4
1.3
—
—
—
0
0
54
356
1.71
2.71
2.1
2.0
—
—
—
0
0
9
24
3.88
2.71
1.4
1.1
—
—
—
0
0
25
129
2.08
2.65
1.3
1.2
16.86
128.24
u/ml
—
7
54
22
108
2.17
2.64
1.9
1.9
0.00
0.26
estimate
0.77
14
19
8
20
4.12
2.59
4.5
2.6
26.72
26.29
mmol/l
—
8
20
5
7
7.29
2.56
3.0
2.3
22.60
33.86
umol/l
—
5
7
8
21
3.92
2.49
1.4
1.0
—
—
—
0
0
11
38
3.00
2.46
1.1
1.0
3.87
2.95
u/ml
—
5
14
13
52
2.61
2.41
1.2
1.1
1.03
2.09
u/ml
—
7
28
8
22
3.74
2.39
1.0
2.8
4.11
3.45
mmol/l
—
8
22
5
8
6.38
2.38
2.8
2.9
1.34
1.01
mmol/l
—
5
8
27
150
1.93
2.35
1.9
1.6
—
—
—
0
0
16
72
2.33
2.35
1.1
1.1
—
—
—
0
0
175
1587
1.96
2.26
5.3
3.6
1.52
1.57
mmol/l
1.13
161
1517
11
41
2.78
2.24
1.5
1.2
—
—
—
0
0
15
68
2.31
2.17
1.1
1.0
—
—
—
0
0
175
1592
1.93
2.16
5.3
3.7
4.71
4.98
mmol/l
3.76
160
1525
166
1489
1.75
2.12
4.4
3.1
1.18
1.15
mmol/l
0.25
151
1412
6
15
4.09
2.05
1.5
1.1
—
—
—
0
0
8
26
3.16
2.03
4.8
7.8
1.00
1.07
%
—
8
26
9
32
2.90
2.03
2.1
1.3
—
—
—
0
0
12
51
2.44
1.99
5.2
7.2
1.79
1.35
mmol/l
0.22
12
46
13
260
0.46
1.97
1.3
1.4
—
—
—
0
0
6
16
3.83
1.95
1.5
1.4
—
—
—
0
0
175
1605
1.84
1.91
5.6
4.0
2.82
2.99
mmol/l
2.03
161
1535
8
28
2.93
1.88
4.8
7.3
0.60
0.59
%
—
8
28
6
17
3.61
1.85
1.5
1.3
0.40
0.49
nmol/l
—
6
17
12
54
2.30
1.78
1.5
1.3
—
—
—
0
0
12
54
2.30
1.78
5.2
6.9
5.93
5.90
kpa
0.04
12
54
6
18
3.40
1.76
4.8
2.4
37.00
36.90
°c
—
6
18
11
48
2.37
1.74
5.5
6.8
4.61
5.07
kpa
0.34
11
48
22
129
1.79
1.65
1.2
2.6
4.32
6.54
umol/l
1.07
13
112
15
78
2.00
1.59
6.8
6.6
103.27
105.05
mmol/l
0.43
15
78
42
297
1.53
1.55
4.0
2.6
1.02
1.02
kg/l
0.34
28
178
11
51
2.23
1.53
1.2
1.3
—
—
—
0
0
5
15
3.39
1.53
1.0
1.2
—
—
—
0
0
13
65
2.07
1.52
2.2
3.9
32.72
64.29
ng/l
—
5
60
7
28
2.55
1.46
5.9
5.1
21.80
24.78
mmol/l
—
7
28
6
22
2.78
1.44
1.5
1.0
—
—
—
0
0
6
22
2.78
1.44
6.8
6.8
0.97
1.07
%
—
6
22
6
22
2.78
1.44
6.3
6.7
0.53
0.67
%
—
6
22
12
60
2.07
1.41
1.5
1.3
—
—
—
0
0
7
29
2.46
1.40
3.4
4.9
26.47
25.15
mmol/l
—
7
24
12
62
2.00
1.31
1.5
1.3
—
—
—
0
0
12
62
2.00
1.31
1.5
1.3
—
—
—
0
0
12
62
2.00
1.31
1.5
1.3
—
—
—
0
0
11
57
1.99
1.19
5.4
4.8
5.02
5.20
kpa
0.23
11
51
11
57
1.99
1.19
5.4
4.8
12.50
15.53
kpa
1.01
11
52
9
46
2.00
1.05
6.7
6.1
—
—
—
0
0
7
36
1.98
0.98
1.1
1.1
—
—
—
0
0
11
62
1.82
0.96
1.8
1.3
—
—
—
0
0
7
37
1.92
0.95
1.0
1.6
46.00
41.89
nmol/l
—
7
37
5
105
0.46
0.91
1.2
1.1
—
—
—
0
0
8
43
1.90
0.88
4.0
2.0
—
—
—
0
0
8
43
1.90
0.88
1.3
1.1
—
—
—
0
0
6
31
1.96
0.85
4.3
6.6
17.52
16.47
%
—
6
26
0
24
0.00
0.79
0.0
1.3
—
—
—
0
0
6
33
1.84
0.79
4.0
9.6
23.58
23.75
mmol/l
—
6
33
5
24
2.11
0.75
5.8
1.7
3.46
4.83
mmol/24h
—
5
18
5
24
2.11
0.75
2.8
4.1
—
—
—
0
0
7
40
1.78
0.72
3.1
2.4
—
—
—
0
0
5
27
1.87
0.69
1.4
1.0
—
—
—
0
0
5
27
1.87
0.69
1.4
2.0
—
—
—
0
0
21
159
1.36
0.58
1.9
1.7
—
—
—
0
0
6
36
1.69
0.57
1.2
1.1
—
—
—
0
0
10
146
0.67
0.54
1.9
1.7
—
—
—
0
0
73
654
1.19
0.51
3.2
2.4
—
—
estimate
—
0
0
30
246
1.26
0.49
2.2
1.8
—
—
—
0
0
5
32
1.58
0.42
1.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
21
256
0.80
0.39
1.8
1.5
—
—
—
0
0
54
489
1.14
0.32
1.8
1.6
—
—
—
0
0
12
151
0.78
0.29
1.6
1.6
1137.94
1000.47
mu/l
0.26
12
125
16
190
0.83
0.24
3.5
2.5
0.40
0.68
ug/l
—
9
110
5
38
1.32
0.23
14.4
3.9
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
409.58
—
0
12
32
289
1.13
0.20
1.8
1.8
—
—
—
0
0
6
48
1.26
0.20
1.2
1.5
331.83
197.02
pmol/l
—
6
48
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
34
367
0.91
0.15
7.1
5.7
—
—
—
0
0
6
55
1.09
0.09
1.7
1.5
—
—
—
0
0
42
421
1.00
0.00
4.0
2.1
—
0.00
—
0
6
40
397
1.01
0.00
3.2
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
0.00
0.0
9.6
—
665.29
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
172.50
—
0
6
11
110
1.00
-0.00
1.6
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.2
—
1.00
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.2
—
1668.17
—
0
6
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint TRACHEOBRONCHOMAL and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have TRACHEOBRONCHOMAL.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: TRACHEOBRONCHOMAL – Tracheo-bronchomalasia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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