No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3709 |
4. Check minimum number of eventsNone |
3709 |
5. Include endpointsNone |
3709 |
6. Filter based on genotype QC (FinnGen only) |
3343 |
Control definitions (FinnGen only)
- Control exclude
- H7_OCUMUSCLE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H52
- Name in latin
- Presbyopia
Similar endpoints
↥List of similar endpoints to
Presbyopia
based on the number of shared cases.
Similar with more cases:
- Disorders of refraction and accommodation
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12798 | 7185 | 5554 |
| Only index persons | 11977 | 6753 | 5224 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.18 | 0.21 | 0.16 |
| Only index persons | 0.23 | 0.25 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 53.91 | 54.12 | 53.65 |
| Only index persons | 53.71 | 53.84 | 53.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3343 | 2136 | 1207 |
| Unadjusted period prevalence (%) | 0.68 | 0.76 | 0.55 |
| Median age at first event (years) | 56.92 | 56.19 | 58.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 3457
- Matched controls
- 34570
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H52.1
ICD-10 Finland
Myopia
12.3
318.6
329
294
H52.2
ICD-10 Finland
Astigmatism
21.4
308.7
234
117
H52.4
ICD-10 Finland
Presbyopia
1276.5
307.7
3305
579
H52.0
ICD-10 Finland
Hypermetropia
27.8
307.7
362
145
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.0
177.2
1047
4346
37002
ICD-8 Finland
Refractive errors, Myopia
+∞
161.7
154
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.2
105.6
1692
10598
CGD20
NOMESCO Finland
Laser-assisted in situ keratomileusis
838.4
83.9
82
*
H50.52
ICD-10 Finland
Exophoria
17.9
80.2
65
37
H04.10
ICD-10 Finland
Dry eye syndrome
2.4
69.5
579
2712
CJE40
NOMESCO Finland
Phakoemulsification with implantation of skleralt fixed artificial lens in posterior chamber
217.3
62.3
64
*
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
12.1
55.7
56
47
XCK00
NOMESCO Finland
Perimetry
3.2
55.3
237
789
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.4
50.8
399
1807
37301
ICD-8 Finland
Strabismus, Concomitans divergens
+∞
47.0
45
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.7
39.8
997
6668
CA1TM
NOMESCO Finland
Calculation of intraocular lens power
5.3
37.2
75
144
37300
ICD-8 Finland
Strabismus, Concomitans convergens
+∞
30.2
29
*
H53.2
ICD-10 Finland
Diplopia
3.1
26.2
110
361
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.3
24.7
199
906
H25.0
ICD-10 Finland
Senile incipient cataract
2.3
24.4
200
916
H53.1
ICD-10 Finland
Subjective visual disturbances
2.0
24.2
260
1325
H50.1
ICD-10 Finland
Divergent concomitant strabismus
125.9
23.6
25
*
H26.4
ICD-10 Finland
After-cataract
2.1
23.1
237
1187
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.9
22.8
301
1646
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
1.9
20.8
276
1512
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
20.1
547
3655
H50.31
ICD-10 Finland
Intermittent exotropia
105.7
19.6
21
*
37303
ICD-8 Finland
Strabismus, Heterophoria (exophoria, esophroria, hypophoria)
+∞
18.8
18
*
ZXA10
NOMESCO Finland
Bilateral
1.6
18.1
502
3365
N03AX12
ATC
[U] gabapentin; oral
1.5
17.4
534
3657
R42
ICD-10 Finland
Dizziness and giddiness
1.5
16.3
662
4802
R06AX27
ATC
desloratadine; oral
1.4
16.2
1004
7857
H50.0
ICD-10 Finland
Convergent concomitant strabismus
85.5
15.6
17
*
H50.2
ICD-10 Finland
Vertical strabismus
22.1
15.5
22
10
J02AC01
ATC
fluconazole; systemic
1.3
15.3
1384
11471
H52.5
ICD-10 Finland
Disorders of accommodation
56.9
14.8
17
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.7
14.7
274
1659
R51.80
ICD-10 Finland
Headache
1.5
14.6
507
3555
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
150.6
14.5
15
*
H53.0
ICD-10 Finland
Amblyopia ex anopsia
5.4
14.5
28
52
XCD10
NOMESCO Finland
Electrophysiological examination of eye
2.9
14.3
67
236
M03BX02
ATC
tizanidine; oral
1.3
13.9
2246
20112
F43
ICPC
Eye, Other diagnostic procedure
2.6
13.8
80
315
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.3
13.7
1534
13040
A02BC05
ATC
esomeprazole; systemic
1.3
13.6
1338
11164
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.7
13.3
268
1657
H02.3
ICD-10 Finland
Blepharochalasis
1.8
12.7
197
1131
R01AD12
ATC
fluticasone furoate; nasal
1.3
12.7
1077
8776
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
12.7
1146
9426
E0000UV, ,
ATC
1.3
12.5
1280
10709
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
130.5
12.4
13
*
R20.2
ICD-10 Finland
Paraesthesia of skin
1.7
12.3
240
1470
Z01.8
ICD-10 Finland
Other specified special examinations
1.4
12.3
722
5560
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.5
12.1
343
2303
A02BC03
ATC
lansoprazole; oral
1.3
11.9
866
6892
G04CA01
ATC
alfuzosin; oral
1.6
11.6
290
1891
A06AC01
ATC
ispaghula (psylla seeds); oral
1.4
11.5
771
6055
R01AD58
ATC
fluticasone, combinations; nasal
1.3
11.5
869
6950
H51.1
ICD-10 Finland
Convergence insufficiency and excess
120.4
11.4
12
*
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
2.2
11.2
96
450
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.3
11.1
743
5830
K30
ICD-10 Finland
Functional dyspepsia
1.5
11.0
367
2550
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
1.5
10.9
345
2368
N95.1
ICD-10 Finland
Menopausal and female climacteric states
1.4
10.7
596
4538
CGD10
NOMESCO Finland
Laser keratoplasty for error of refraction
12.9
10.6
18
14
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.6
10.6
285
1890
R01AD09
ATC
mometasone; nasal
1.3
10.4
1529
13296
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
110.4
10.4
11
*
G04BD12
ATC
mirabegron; oral
1.5
10.4
304
2052
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.4
10.3
486
3597
CJE99
NOMESCO Finland
Other extracapsular cataract operation using phakoemulsification technique
23.4
10.2
14
6
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
1.7
10.0
186
1127
X59
ICD-10 Finland
Exposure to unspecified factor
1.4
9.9
568
4346
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.5
9.8
285
1923
J05AB11
ATC
valaciclovir; oral
1.4
9.7
450
3321
N02AX02
ATC
tramadol; systemic, rectal
1.3
9.6
1345
11598
N05CF02
ATC
zolpidem; oral
1.4
9.6
564
4331
J01FA10
ATC
azithromycin; systemic
1.3
9.5
1900
17053
ZXD20
NOMESCO Finland
Day surgery
1.4
9.4
383
2760
R35
ICD-10 Finland
Polyuria
1.7
9.4
172
1037
37600
ICD-8 Finland
Detachment of retina, Primaria
17.6
9.4
14
8
H93.1
ICD-10 Finland
Tinnitus
1.6
9.4
219
1406
R03BA08
ATC
ciclesonide; inhalant
1.5
9.3
274
1852
R03AK07
ATC
formoterol and budesonide; inhalant
1.3
9.3
723
5780
J01MA02
ATC
ciprofloxacin; systemic
1.3
9.3
1108
9362
A98
ICPC
Health maint/preventive medicine
1.9
9.2
3363
32799
ZXE10
NOMESCO Finland
More than one and less than three hours
1.3
9.1
1031
8653
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.4
9.0
426
3155
H54.7
ICD-10 Finland
Unspecified visual loss
3.9
8.9
25
64
D07AB02
ATC
hydrocortisone butyrate; topical
1.3
8.8
876
7228
ZXE00
NOMESCO Finland
One hour or less
1.3
8.6
1119
9532
D22
ICD-10 Finland
Melanocytic naevi
1.6
8.4
173
1076
H50.30
ICD-10 Finland
Intermittent esotropy
90.3
8.4
9
*
UJF32
NOMESCO Finland
Coloscopy
1.3
8.3
726
5884
AA1AD
NOMESCO Finland
CT of head and brain
1.3
8.3
732
5943
G44.2
ICD-10 Finland
Tension-type headache
1.4
8.3
420
3145
J31.0
ICD-10 Finland
Chronic rhinitis
1.5
8.3
273
1891
M25.5
ICD-10 Finland
Pain in joint
1.2
8.2
1144
9814
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
1.5
8.1
224
1494
G50.0
ICD-10 Finland
Trigeminal neuralgia
2.3
8.0
59
261
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.5
8.0
296
2095
N06AX21
ATC
duloxetine; oral
1.4
8.0
389
2892
J45
ICD-10 Finland
Asthma
1.4
7.9
316
2269
X58
ICD-10 Finland
Exposure to other specified factors
1.4
7.8
448
3419
L82
ICD-10 Finland
Seborrhoeic keratosis
1.3
7.8
563
4445
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
1.9
7.8
101
552
H50.51
ICD-10 Finland
Esophoria
10.8
7.8
14
13
H43.3
ICD-10 Finland
Other vitreous opacities
2.4
7.7
50
209
N40
ICD-10 Finland
Hyperplasia of prostate
1.4
7.7
412
3114
R07.4
ICD-10 Finland
Chest pain, unspecified
1.3
7.6
811
6732
S01GX01
ATC
cromoglicic acid; ophthalmic
1.3
7.6
605
4842
ZXA00
NOMESCO Finland
Right side
1.3
7.6
684
5564
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.5
7.4
261
1834
W49
ICD-10 Finland
Exposure to other and unspecified inanimate mechanical forces
2.3
7.2
51
222
Z2221
NOMESCO Finland
Medical doctor
1.3
7.2
757
6267
CJB20
NOMESCO Finland
Irrigation and polishing of secondary cataract
15.8
7.2
11
7
H46
ICD-10 Finland
Optic neuritis
2.8
7.1
35
128
G35
ICD-10 Finland
Multiple sclerosis
2.2
7.1
54
243
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.3
7.1
842
7071
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
7.1
1668
15035
H40.0
ICD-10 Finland
Glaucoma suspect
1.5
7.1
206
1392
N03AX16
ATC
[U] pregabalin
1.3
7.1
681
5581
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
2.5
7.0
40
158
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
1.5
7.0
209
1420
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
1.8
7.0
99
558
103
Kela drug reimbursment
Diabetes, insulin-treated
0.8
6.9
443
5634
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.2
6.9
1651
14884
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.3
6.9
794
6640
H53.4
ICD-10 Finland
Visual field defects
2.2
6.8
54
247
N02AJ06
ATC
codeine and paracetamol; systemic
1.2
6.8
1386
12299
WX001
NOMESCO Finland
Nonpharmacological sedation or pain relief
10.9
6.8
12
11
J01DB01
ATC
cefalexin; oral
1.3
6.7
2702
25611
XA800
NOMESCO Finland
Neuropsychological investigation
1.6
6.7
135
837
M54.5
ICD-10 Finland
Low back pain
1.2
6.7
1172
10244
W20
ICD-10 Finland
Struck by thrown, projected or falling object(s)
2.6
6.7
36
138
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
3.9
6.7
19
49
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
1.3
6.7
747
6224
S13.4
ICD-10 Finland
Sprain and strain of cervical spine
1.7
6.7
122
738
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
1.5
6.6
179
1191
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
1.6
6.6
152
975
L57.0
ICD-10 Finland
Actinic keratosis
1.5
6.6
213
1471
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.2
6.6
881
7489
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
1.6
6.5
128
790
E000006, ,
ATC
1.5
6.5
172
1140
L04AX01
ATC
azathioprine; systemic
1.7
6.5
116
699
D01BA02
ATC
terbinafine; oral
1.2
6.5
753
6302
R23.3
ICD-10 Finland
Spontaneous ecchymoses
2.1
6.4
59
287
R06.0
ICD-10 Finland
Dyspnoea
1.3
6.4
717
5976
C08CA05
ATC
nifedipine; systemic
1.7
6.4
122
748
R03DC03
ATC
montelukast; oral
1.3
6.4
508
4061
Z71
ICD-10 Finland
Persons encountering health services for other counselling and medical advice, not elsewhere classified
1.7
6.3
106
628
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
1.6
6.3
157
1027
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
1.8
6.3
84
466
37000
ICD-8 Finland
Refractive errors, Astigmatismus
+∞
6.3
6
*
A97
ICPC
No disease
1.3
6.2
518
4162
N06AX11
ATC
mirtazapine; oral
1.2
6.2
1013
8777
K07.60
ICD-10 Finland
Snapping jaw
1.5
6.2
157
1030
G04BD04
ATC
oxybutynin; oral, transdermal
1.7
6.2
109
654
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.2
6.2
827
7023
UKC02
NOMESCO Finland
Cystoscopy
1.4
6.2
341
2587
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.4
6.2
276
2024
215
Kela drug reimbursment
Diabetes, non-insulin-treated
0.8
6.1
435
5458
H57.1
ICD-10 Finland
Ocular pain
1.7
6.1
114
695
D06BB03
ATC
aciclovir; topical
1.6
6.1
132
836
H43.8
ICD-10 Finland
Other disorders of vitreous body
1.4
6.1
273
2004
H35.4
ICD-10 Finland
Peripheral retinal degeneration
2.9
6.0
27
94
H44.2
ICD-10 Finland
Degenerative myopia
10.0
6.0
11
11
D06BX01
ATC
metronidazole; topical
1.4
6.0
327
2475
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.3
6.0
525
4245
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1710
14411
1.37
17.89
2.7
2.5
79.63
77.03
nmol/l
3.33
1614
13397
1876
16120
1.36
16.93
4.0
3.6
7.12
5.50
estimate
0.12
356
3186
1887
16238
1.36
16.83
4.1
3.6
0.00
0.13
estimate
0.68
341
2979
1855
15952
1.35
16.44
4.0
3.6
0.00
0.00
estimate
0.23
353
3122
2556
23300
1.37
14.34
4.8
4.4
10.05
11.04
mm/h
3.72
2436
22169
3038
28631
1.50
13.45
5.8
5.4
1.77
1.85
mu/l
3.66
2899
27002
2658
24462
1.37
13.44
4.8
4.5
14.43
14.57
pmol/l
2.81
2512
23004
712
5406
1.40
13.33
1.6
1.5
—
—
—
0
0
1723
14954
1.30
12.93
3.2
3.0
111.17
121.00
ug/l
0.83
1654
14232
1090
8915
1.33
12.51
3.5
3.0
0.02
0.08
estimate
1.03
287
2489
1436
12323
1.28
11.15
3.9
3.5
0.12
0.04
estimate
0.45
300
2577
2776
25937
1.36
11.14
18.6
17.8
13.44
13.54
%
5.18
2750
25615
1126
9375
1.30
11.03
2.2
2.2
167.49
197.16
u/l
0.72
1068
8952
378
2655
1.48
10.68
2.7
2.4
14.15
13.64
nmol/l
0.67
347
2450
2085
18792
1.28
10.65
4.9
4.1
2257.64
1497.59
e6/l
0.28
64
227
2001
18019
1.26
9.95
9.9
10.2
3.80
3.99
e9/l
3.91
1766
15743
1081
9053
1.28
9.88
2.9
2.7
0.13
0.03
0.34
16
144
1873
16756
1.26
9.77
7.0
6.8
0.18
0.19
e9/l
1.68
1687
14821
1847
16516
1.25
9.59
7.0
6.7
1.92
1.94
e9/l
0.28
1667
14713
178
1089
1.67
9.23
1.9
2.0
40.05
39.35
nmol/l
0.15
172
1058
2814
26549
1.32
9.06
19.4
18.3
333.28
332.45
g/l
5.58
2806
26436
1267
10933
1.25
8.75
4.1
3.7
92.43
81.06
e6/l
0.17
911
7674
3266
31643
1.58
8.65
6.1
5.7
2.85
2.85
mmol/l
0.15
3135
30099
203
1310
1.58
8.51
1.4
1.4
—
—
—
0
0
3238
31352
1.52
8.13
5.5
5.1
4.85
4.81
mmol/l
1.88
3108
29930
1005
8501
1.26
8.13
4.2
3.8
0.00
0.00
estimate
2.03
328
2949
181
1150
1.61
8.11
1.7
1.7
—
—
—
0
0
1603
14270
1.23
8.10
1.9
1.9
1.33
1.42
mmol/l
4.55
1371
12261
144
865
1.69
8.04
2.0
2.0
217.18
203.88
pmol/l
0.91
135
824
334
2421
1.42
7.96
1.5
1.5
—
—
—
0
0
205
1349
1.55
7.91
1.8
1.7
4.19
4.46
mg/l
0.08
148
1016
3343
32633
1.74
7.88
12.9
12.1
26.88
27.41
u/l
1.08
3288
31982
330
2411
1.41
7.52
1.3
1.3
128.14
209.78
u/ml
2.44
310
2265
1013
8692
1.23
7.00
2.4
2.5
329.66
331.42
umol/l
0.24
914
7875
2546
23952
1.24
6.94
8.4
8.5
75.48
77.82
u/l
1.55
2442
22972
3105
29949
1.36
6.86
4.6
4.3
1.27
1.33
mmol/l
5.45
2962
28255
3347
32752
1.69
6.86
19.4
18.5
74.86
74.33
umol/l
0.42
3334
32478
2221
20622
1.22
6.79
3.0
3.0
—
—
—
0
0
553
4439
1.29
6.73
1.9
2.2
29.35
29.45
s
0.09
538
4323
3218
31237
1.44
6.73
5.4
5.1
1.52
1.48
mmol/l
5.31
3083
29687
871
7383
1.24
6.70
1.8
1.8
0.95
1.03
mg/l
0.24
671
5751
3397
33399
1.99
6.66
23.6
22.2
91.16
91.06
fl
0.70
3385
33150
3397
33402
1.98
6.61
24.2
22.8
42.38
41.51
%
0.31
3383
33135
3397
33403
1.98
6.59
23.7
22.3
4.54
4.54
e12/l
0.43
3365
32801
3397
33404
1.98
6.57
23.7
22.3
6.36
6.57
e9/l
6.61
3367
32798
1088
9456
1.22
6.56
3.4
3.2
103.56
85.09
e6/l
0.15
846
7162
3397
33408
1.97
6.51
23.8
22.4
137.49
136.83
g/l
2.28
3385
33158
1445
12937
1.20
6.33
2.1
2.0
98.76
97.74
pmol/l
0.37
772
6920
3394
33391
1.90
6.15
23.7
22.3
255.21
257.45
e9/l
1.28
3371
32875
808
6851
1.23
6.12
4.5
3.9
22.13
21.28
%
0.79
340
2985
562
4572
1.27
6.12
2.2
2.1
3.41
3.52
ratio
1.20
436
3546
268
3608
0.72
6.12
5.0
4.7
31.79
31.48
%
0.19
188
2531
882
7551
1.23
6.09
1.3
1.3
1.96
1.79
u/ml
0.14
265
2208
3066
29598
1.32
6.07
6.0
5.9
38.13
38.93
mmol/mol
7.68
2947
28216
763
6448
1.24
5.95
2.8
2.6
4.67
5.59
e6/l
1.68
701
5892
1493
13473
1.19
5.84
4.9
5.2
36.91
36.31
g/l
4.56
1393
12737
637
5296
1.25
5.75
3.0
3.0
0.67
0.71
ug/l
0.68
344
3109
41
181
2.28
5.71
1.4
1.2
0.69
0.55
ratio
0.63
23
112
933
8090
1.21
5.60
4.1
4.1
95.22
93.51
%
1.50
907
7910
428
3426
1.28
5.29
1.8
1.8
3.50
3.55
mmol/l
0.40
297
2395
1456
13197
1.18
5.22
6.5
6.7
1.21
1.21
mmol/l
0.49
1370
12356
1655
15164
1.18
5.18
7.2
6.8
29.30
28.55
%
2.30
1592
14469
199
1436
1.41
4.94
1.4
1.3
0.68
1.05
u/ml
0.31
13
112
927
8120
1.19
4.88
3.1
3.1
0.37
0.38
e6/l
0.06
670
5861
3096
30059
1.29
4.86
14.4
13.9
83.46
83.83
ml/min/173m2
0.59
2910
27961
515
4267
1.24
4.75
2.7
2.5
115.97
119.59
ug/g
0.10
427
3488
90
554
1.64
4.73
3.7
3.3
24.65
24.01
mg/l
0.06
63
370
610
5149
1.22
4.72
2.9
2.7
0.89
0.97
e6/l
0.21
329
2686
1608
14771
1.17
4.71
6.9
7.3
1.22
1.21
mmol/l
0.95
1415
12957
766
6616
1.20
4.69
1.5
1.5
2.22
2.41
g/l
3.02
501
4314
1625
14945
1.16
4.67
7.0
6.6
56.21
56.70
%
1.06
1579
14352
3124
30390
1.29
4.64
15.4
14.7
21.44
22.16
mg/l
0.59
2579
24854
968
8544
1.18
4.64
5.0
4.7
2.78
2.15
ug/l
0.33
905
7866
1120
10020
1.17
4.54
2.8
2.7
57.62
68.74
u/l
0.78
1039
9397
38
180
2.12
4.53
1.1
1.1
1.30
3.41
nmol/l
—
10
34
802
6977
1.19
4.52
4.3
3.7
1.02
1.24
kg/l
0.50
514
4598
683
5855
1.21
4.51
1.5
1.5
—
—
—
0
0
3079
29914
1.27
4.51
5.2
4.9
5.72
5.89
mmol/l
15.90
2916
28135
3202
31268
1.33
4.49
16.9
16.5
3.96
3.96
mmol/l
0.64
3158
30726
1178
10592
1.17
4.47
3.3
3.7
2.35
2.36
mmol/l
0.40
1093
9776
109
715
1.54
4.41
1.2
1.3
17.11
36.45
e6/l
0.69
75
520
46
240
1.93
4.25
1.1
1.1
232.70
276.49
mg/l
1.33
37
215
788
6882
1.19
4.22
1.4
1.4
24.69
31.03
iu/ml
0.70
235
2218
71
426
1.68
4.16
1.3
1.3
—
—
—
0
0
3189
31167
1.30
4.09
16.8
16.4
139.87
139.82
mmol/l
0.68
3155
30684
278
2178
1.30
4.08
3.2
3.8
82.48
83.55
ng/l
0.05
245
1938
109
730
1.51
4.04
1.3
1.4
1462.53
1414.52
e6/l
0.01
81
567
1514
13952
1.15
4.02
11.6
11.0
0.00
0.00
e9/l
1.10
1241
11402
46
247
1.87
3.92
1.1
1.2
34.58
40.16
mg/l
0.59
34
215
52
291
1.80
3.90
5.8
3.7
8.13
7.41
mmol/l
0.27
45
253
347
2823
1.25
3.78
3.2
3.2
—
—
—
0
0
272
2151
1.29
3.74
3.7
3.4
4.44
4.51
pmol/l
0.61
244
1935
1236
11275
1.15
3.71
3.5
3.3
34.10
48.39
ng/l
0.60
721
7075
118
827
1.44
3.53
1.2
1.2
500.90
543.70
mg/l
0.56
110
791
540
4632
1.20
3.51
3.0
2.9
2.74
2.59
e6/l
0.12
255
2165
134
963
1.41
3.50
1.5
1.4
289.99
289.54
ug/g
0.01
70
559
666
5821
1.18
3.49
2.6
2.9
2.43
2.44
mmol/l
2.42
607
5233
146
1071
1.38
3.39
1.7
1.5
94.30
0.35
iu/ml
0.49
35
164
2403
23006
1.15
3.34
3.6
3.4
42.72
46.88
u/l
1.79
2300
21988
876
7879
1.15
3.13
1.6
1.6
20.85
20.45
nmol/l
0.38
780
6821
1495
13926
1.13
3.11
2.6
2.7
—
—
estimate
—
0
0
371
3108
1.22
3.10
2.4
2.4
352.82
370.65
nmol/l
1.14
347
2909
240
1921
1.27
3.04
2.7
2.9
134.73
143.62
ng/l
0.13
215
1734
124
907
1.38
2.97
1.2
1.1
3.43
3.82
0.23
24
148
17
69
2.47
2.95
1.1
1.2
97.35
100.74
%
0.20
17
69
288
2364
1.24
2.94
1.2
1.2
118.67
153.44
u/ml
1.21
121
936
189
1475
1.30
2.93
1.9
1.9
7.56
6.74
iu/ml
0.14
41
371
45
266
1.70
2.88
1.2
1.1
18.26
16.93
u/ml
0.12
20
118
715
6387
1.15
2.79
1.3
1.3
8.21
9.62
u/ml
0.28
323
2691
183
1434
1.29
2.77
2.6
2.1
39.16
40.06
u/l
0.24
170
1310
1739
16420
1.12
2.76
6.5
7.0
11.41
11.01
umol/l
0.51
1669
15776
42
249
1.70
2.68
1.2
1.4
214.38
198.48
pmol/l
0.10
42
249
12
43
2.80
2.64
1.3
1.0
—
—
—
0
0
315
2641
1.21
2.64
3.0
2.9
10.49
10.53
g/l
0.04
287
2457
101
733
1.39
2.58
1.1
1.2
3.70
3.71
mmol/l
0.03
92
698
870
7914
1.13
2.57
2.7
3.0
606.78
920.77
ng/l
3.58
718
6661
807
7308
1.14
2.56
2.4
2.3
2.56
2.77
mg/l
2.13
702
6415
110
811
1.37
2.56
2.4
3.0
2.52
1.89
index
0.17
60
433
301
2530
1.21
2.47
2.6
2.4
24.20
21.26
au/ml
0.24
37
325
42
256
1.65
2.45
1.1
1.1
8.03
9.04
iu/ml
0.10
11
77
38
227
1.68
2.39
1.1
1.1
—
—
—
0
0
18
84
2.15
2.34
1.4
5.0
9.76
10.52
kpa
0.93
18
84
18
84
2.15
2.34
1.4
5.0
4.80
4.94
kpa
0.31
18
84
282
2369
1.21
2.34
1.8
1.8
—
—
—
0
0
46
291
1.59
2.33
1.2
1.3
1.22
0.97
u/ml
0.09
26
156
285
2399
1.20
2.32
1.3
1.4
32.60
34.78
iu/l
0.46
250
2085
311
2641
1.20
2.30
1.8
1.8
—
—
—
0
0
380
3287
1.18
2.28
5.5
6.1
—
—
—
0
0
307
2608
1.19
2.27
2.2
2.6
71.23
71.07
ml/min/173m2
0.03
142
1063
8
23
3.48
2.27
1.1
1.0
—
—
—
0
0
277
2333
1.20
2.25
1.4
1.3
64.72
52.62
au/ml
0.32
18
170
120
918
1.32
2.23
2.6
2.2
10.21
11.59
mg/l
1.17
110
864
19
93
2.05
2.21
1.0
1.4
97.88
94.61
%
—
8
46
31
180
1.73
2.18
1.0
1.1
0.94
1.12
u/l
2.67
14
83
19
94
2.03
2.15
1.0
1.2
98.25
93.61
%
—
8
46
77
1052
0.73
2.08
2.1
2.0
—
—
—
0
0
113
867
1.31
2.08
1.4
1.2
57.31
43.52
u/ml
0.34
15
91
469
4156
1.15
2.06
1.9
1.7
1208.70
1172.85
nmol/l
0.36
354
3265
1408
13300
1.10
2.00
12.7
11.9
1.18
1.18
inr
0.12
1183
10953
228
1909
1.21
2.00
4.1
3.6
25.73
55.77
u/ml
2.83
223
1846
1841
17614
1.10
1.99
5.0
5.0
6.42
6.64
mmol/l
6.09
1771
16832
81
596
1.37
1.98
1.6
1.4
0.35
0.31
nmol/l
0.29
56
417
89
666
1.35
1.96
1.4
1.4
39.31
33.44
u/l
0.52
64
534
356
3106
1.16
1.94
2.4
2.6
34.47
57.34
u/l
0.85
307
2662
284
2435
1.18
1.92
3.1
2.3
0.23
0.43
e6/l
1.43
269
2307
664
6046
1.12
1.91
1.8
1.7
35489941.70
38619796.67
pmol/l
0.04
572
5215
39
252
1.55
1.86
2.4
3.3
11.86
12.84
index
0.33
21
160
69
505
1.37
1.77
1.2
1.1
1.09
3.15
1.65
15
102
21
361
0.58
1.75
2.7
3.2
0.95
0.82
nmol/l
0.62
11
289
164
1351
1.22
1.73
1.7
1.6
—
—
—
0
0
80
603
1.33
1.71
1.1
1.1
4.03
17.06
au/ml
6.14
23
174
18
96
1.88
1.70
1.2
1.2
—
—
—
0
0
46
316
1.46
1.68
1.1
1.1
—
—
—
0
0
24
141
1.71
1.68
1.5
1.4
2.33
4.17
umol/l
4.39
19
118
565
5141
1.12
1.65
3.4
3.8
0.83
0.82
mmol/l
1.61
525
4900
33
212
1.56
1.65
2.8
2.5
579.67
555.10
e6/l
0.10
24
171
153
1259
1.23
1.64
1.6
1.7
9.75
14.16
u/ml
0.87
35
344
72
952
0.75
1.63
1.7
1.8
—
—
—
0
0
185
1553
1.20
1.63
1.1
1.1
0.62
0.65
ratio
0.26
29
207
143
1181
1.22
1.51
1.7
1.8
—
—
—
0
0
6
21
2.86
1.50
1.3
1.9
59.00
39.62
umol/l
—
6
21
19
108
1.76
1.50
6.0
4.3
—
—
—
0
0
1212
11493
1.08
1.49
3.7
3.4
31.11
34.07
u/l
0.92
1168
10915
66
496
1.34
1.48
1.4
1.3
—
—
—
0
0
66
496
1.34
1.48
1.4
1.3
—
—
—
0
0
77
592
1.31
1.48
3.4
2.7
17.41
16.54
%
2.31
77
580
127
1039
1.23
1.47
1.8
1.8
0.23
0.24
g/l
0.37
118
990
65
489
1.34
1.45
1.1
1.1
4.33
3.99
eliau/ml
0.08
28
246
115
933
1.24
1.44
2.3
2.8
—
—
—
0
0
59
438
1.35
1.44
1.9
1.9
1.55
1.69
mmol/l
0.79
59
426
40
278
1.44
1.42
1.9
1.2
127.63
111.42
pmol/l
1.54
40
278
65
492
1.33
1.40
1.7
1.3
0.32
0.36
nmol/l
—
5
28
115
937
1.24
1.40
1.5
2.4
10.62
10.22
g/l
0.37
105
869
16
275
0.58
1.38
2.2
1.7
—
—
—
0
0
16
275
0.58
1.38
2.2
1.7
—
—
—
0
0
16
275
0.58
1.38
2.2
1.7
—
—
—
0
0
263
2310
1.15
1.37
2.3
2.9
66.85
66.90
g/l
0.03
244
2167
116
948
1.23
1.37
2.1
2.5
3.37
3.63
g/l
1.50
109
903
103
831
1.25
1.37
1.2
1.1
8.02
6.28
eliau/ml
0.17
18
118
616
5696
1.10
1.34
3.6
3.6
354.74
469.63
ng/l
0.48
436
4047
0
39
0.00
1.33
0.0
1.0
—
—
—
0
0
79
621
1.28
1.31
2.1
2.1
5.31
5.40
mmol/24h
0.09
74
562
192
1655
1.17
1.30
1.1
1.1
—
—
—
0
0
108
884
1.23
1.28
1.3
1.4
11.54
12.18
u/l
0.11
81
712
30
202
1.49
1.27
5.2
3.6
30.40
25.47
mu/l
0.23
30
195
14
77
1.82
1.25
1.0
1.2
6.36
11.96
pmol/l
—
7
30
6
25
2.40
1.24
1.0
1.0
0.15
0.04
u/ml
—
6
19
102
834
1.23
1.23
1.2
1.2
—
—
—
0
0
430
3925
1.11
1.22
5.8
6.3
1.02
1.03
mmol/l
0.46
397
3681
10
49
2.04
1.22
3.5
2.2
—
—
—
0
0
32
221
1.45
1.21
1.0
1.0
834.17
770.64
ng/l
0.31
24
156
46
341
1.35
1.18
1.3
1.1
—
—
—
0
0
32
223
1.44
1.16
1.0
1.0
36.46
39.82
ng/l
0.16
24
156
0
34
0.00
1.16
0.0
2.1
—
—
—
0
0
132
1117
1.19
1.14
1.4
1.3
48.26
36.21
u/ml
—
7
63
32
225
1.43
1.12
1.3
1.6
76.34
76.74
umol/l
0.04
32
225
48
362
1.33
1.11
1.7
1.6
54.76
56.58
%
0.10
29
221
46
345
1.34
1.11
1.1
1.1
—
50.08
—
0
5
128
1084
1.19
1.10
1.8
1.8
1.15
1.20
g/l
1.33
121
1034
109
910
1.20
1.10
2.1
2.0
3.54
4.13
iu/l
0.31
31
385
25
168
1.49
1.09
1.4
1.7
2.55
4.81
nmol/l
0.72
19
131
64
504
1.27
1.09
1.1
1.1
3.28
2.89
u/ml
0.10
27
199
237
2106
1.13
1.09
2.1
1.9
1.42
1.31
g/l
0.21
216
1963
5
21
2.38
1.09
1.0
1.3
—
—
—
0
0
38
278
1.37
1.07
1.3
1.1
—
—
—
0
0
43
321
1.34
1.07
1.6
1.5
297.04
325.23
mu/l
0.32
25
245
11
59
1.87
1.07
1.3
1.2
6.15
18.85
nmol/l
—
6
39
100
832
1.21
1.05
1.2
1.2
—
—
—
0
0
38
279
1.37
1.05
1.3
1.1
—
—
—
0
0
89
732
1.22
1.05
1.1
1.1
0.76
1.68
u/ml
1.29
41
367
72
579
1.25
1.04
1.1
1.1
0.63
1.41
u/ml
1.17
32
260
25
170
1.47
1.04
1.4
1.5
2.15
1.97
umol/l
0.43
16
152
957
10048
0.93
1.04
3.8
4.0
4.40
7.37
mg/mmol
2.72
558
6166
9
46
1.96
1.03
3.0
1.7
—
—
—
0
0
39
289
1.35
1.03
1.3
1.1
—
—
—
0
0
39
289
1.35
1.03
1.3
1.1
—
—
—
0
0
48
620
0.77
1.01
3.9
3.8
144.67
845.67
u/ml
0.98
40
580
24
163
1.48
1.01
1.2
1.3
151.29
167.45
mmol/24h
0.45
24
163
29
205
1.42
1.00
1.4
1.6
—
—
—
0
0
164
1432
1.15
0.99
1.9
1.8
—
—
—
0
0
418
3858
1.09
0.98
2.6
2.8
7.88
7.24
umol/l
0.26
375
3430
0
29
0.00
0.97
0.0
1.2
—
—
—
0
0
99
831
1.20
0.97
1.6
2.3
0.04
0.02
g/l
0.16
88
766
30
215
1.40
0.97
3.3
2.7
227.83
226.15
e6/l
0.01
23
182
76
622
1.23
0.96
1.1
1.1
4.33
3.41
u/ml
0.24
34
294
0
31
0.00
0.96
0.0
2.2
—
0.68
—
0
31
16
246
0.65
0.94
1.5
1.3
—
—
—
0
0
1003
10477
0.94
0.92
3.1
3.3
7.89
7.89
mmol/l
0.01
865
8998
53
419
1.27
0.91
1.7
1.3
0.17
0.22
nmol/l
0.66
40
333
6
28
2.14
0.91
18.3
10.9
5.50
5.13
mmol/l
—
6
28
18
118
1.53
0.90
1.3
1.5
—
—
—
0
0
17
110
1.55
0.90
2.6
2.8
30.34
29.69
umol/l
0.09
12
77
15
94
1.60
0.90
1.1
1.1
—
—
—
0
0
250
2260
1.11
0.90
1.8
2.2
8.97
8.08
ug/l
0.19
228
2054
11
63
1.75
0.90
1.0
1.1
78.44
7.33
u/ml
0.46
11
63
20
289
0.69
0.88
1.6
1.4
—
—
—
0
0
37
280
1.32
0.88
1.9
1.5
26.74
34.90
%
0.61
19
163
30
221
1.36
0.85
1.0
1.0
337.64
294.62
ng/l
0.24
22
159
33
247
1.34
0.85
1.9
2.1
—
—
—
0
0
66
541
1.22
0.85
1.1
1.1
4.20
2.83
u/ml
0.32
29
240
12
191
0.63
0.84
1.3
1.1
—
—
—
0
0
82
688
1.20
0.84
2.9
2.3
135.00
131.69
g/l
0.57
70
535
8
46
1.74
0.82
1.0
1.1
—
—
—
0
0
49
390
1.26
0.82
1.2
1.2
6.87
7.55
mmol/l
1.07
43
344
6
32
1.88
0.81
1.0
1.2
1.42
1.81
umol/24h
—
6
32
126
1440
0.87
0.81
1.5
1.5
—
—
—
0
0
112
969
1.16
0.81
2.1
2.4
181.77
187.44
%
0.28
107
919
129
1471
0.87
0.81
2.2
2.2
0.00
0.02
estimate
1.31
36
489
56
454
1.24
0.81
1.1
1.1
0.17
0.41
u/ml
0.42
15
133
94
802
1.18
0.81
1.6
2.4
0.00
0.00
g/l
-0.00
82
713
54
436
1.24
0.80
1.5
1.4
291.80
328.47
pmol/l
0.58
44
383
8
47
1.70
0.80
1.6
2.1
—
—
—
0
0
88
747
1.18
0.80
1.6
2.4
0.00
0.00
g/l
-0.00
81
712
72
600
1.20
0.80
1.1
1.1
1.44
1.07
u/ml
0.15
28
233
39
303
1.29
0.79
1.3
1.1
—
—
—
0
0
165
1470
1.13
0.79
2.5
2.8
0.64
0.61
%
0.66
165
1459
121
1056
1.15
0.78
1.5
2.4
2.82
2.88
g/l
0.24
112
994
67
556
1.21
0.78
3.4
4.3
5.04
5.03
kpa
0.03
67
549
7
123
0.57
0.77
1.4
1.8
39.66
40.75
g/l
—
7
123
249
2275
1.10
0.76
3.8
4.2
1.22
1.23
mmol/l
0.82
215
2002
67
558
1.20
0.76
1.3
1.2
4.82
3.10
u/ml
0.24
28
195
0
28
0.00
0.76
0.0
1.3
—
—
—
0
0
40
315
1.27
0.74
1.0
1.1
—
—
—
0
0
5
24
2.08
0.74
2.2
1.5
4.57
4.76
mg/l
—
5
15
5
24
2.08
0.74
2.2
1.5
4.62
1.75
mg/l
—
5
18
5
24
2.08
0.74
2.2
1.5
0.29
2.64
mg/l
—
5
16
17
116
1.47
0.74
1.2
1.3
15.82
16.71
umol/l
0.43
12
102
110
959
1.15
0.74
1.8
2.5
0.73
0.91
g/l
0.22
96
857
32
245
1.31
0.73
1.9
1.7
3.97
3.87
mg/l
0.03
32
238
118
1035
1.15
0.73
1.5
1.3
1.86
6.12
u/ml
0.66
13
90
21
151
1.39
0.71
2.2
2.3
18.34
73.90
ug/l
0.56
21
138
280
3030
0.92
0.71
2.4
2.3
0.22
0.22
g/l
0.67
263
2852
5
26
1.92
0.70
1.0
1.3
5.80
24.46
u/l
—
5
26
27
203
1.33
0.70
2.5
2.9
39.54
42.98
%
0.48
16
105
29
221
1.31
0.69
1.5
1.2
—
—
—
0
0
10
157
0.64
0.68
2.9
2.0
—
—
—
0
0
10
157
0.64
0.68
2.9
2.0
—
—
—
0
0
10
157
0.64
0.68
2.9
2.0
—
—
—
0
0
10
157
0.64
0.68
2.9
2.0
—
—
—
0
0
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
10
61
1.64
0.68
1.1
1.2
—
75.78
—
0
18
22
161
1.37
0.68
1.6
2.4
7.64
7.88
mmol/l
0.17
22
161
7
119
0.59
0.67
3.7
2.3
—
—
—
0
0
7
119
0.59
0.67
3.7
2.3
—
—
—
0
0
7
119
0.59
0.67
3.7
2.3
—
—
—
0
0
99
864
1.15
0.67
1.3
1.3
—
—
—
0
0
12
78
1.54
0.65
1.1
1.1
—
—
—
0
0
290
3119
0.92
0.65
3.9
4.5
46.52
22.07
ug/l
0.34
221
2498
29
224
1.30
0.64
3.0
2.4
26.87
27.39
mg/l
0.02
23
153
29
224
1.30
0.64
1.5
1.2
—
—
—
0
0
77
663
1.17
0.63
3.8
2.9
8.31
8.19
kpa
0.25
77
652
96
841
1.15
0.63
2.1
1.7
—
—
—
0
0
47
387
1.22
0.63
1.7
1.7
—
—
—
0
0
47
387
1.22
0.63
1.6
1.6
—
—
—
0
0
107
946
1.14
0.62
1.3
1.3
—
—
—
0
0
54
640
0.84
0.60
2.5
2.4
150.67
127.36
ug/min
0.14
36
383
86
982
0.87
0.60
2.8
3.3
24.77
24.97
mmol/l
0.30
78
914
189
1733
1.10
0.58
5.3
7.0
24.95
24.59
mmol/l
0.84
184
1666
19
140
1.36
0.58
1.1
1.0
—
—
—
0
0
18
242
0.74
0.57
1.7
1.5
12948.18
47566.57
e6/l
0.96
11
136
116
1037
1.12
0.57
1.5
1.3
9.39
7.45
u/ml
0.17
21
149
6
35
1.72
0.57
1.3
4.2
40.00
44.09
umol/l
—
6
28
68
586
1.16
0.57
1.2
1.5
162.33
155.35
au/ml
0.20
18
166
5
88
0.57
0.56
1.0
1.1
—
—
—
0
0
163
1488
1.10
0.56
2.5
2.9
1.34
1.31
%
0.12
163
1477
109
974
1.12
0.55
2.6
3.0
1.37
1.44
mg/l
0.41
104
912
99
1112
0.89
0.55
1.9
2.0
3.18
2.03
ug/l
0.21
88
1010
77
878
0.87
0.54
2.6
3.8
33.11
37.82
mg/l
0.29
59
748
171
1568
1.10
0.54
1.5
1.5
—
—
—
0
0
277
2592
1.07
0.54
9.0
8.8
1.36
1.29
mmol/l
0.63
270
2549
29
361
0.80
0.53
2.3
1.8
—
—
—
0
0
6
39
1.54
0.53
1.3
1.2
—
—
—
0
0
359
3393
1.06
0.53
1.7
1.8
—
—
—
0
0
60
695
0.86
0.53
4.0
3.2
35.33
36.65
umol/l
0.11
54
649
123
1111
1.11
0.52
1.5
2.4
4.16
4.27
g/l
0.69
114
1048
123
1111
1.11
0.52
1.5
2.4
6.96
7.30
g/l
1.32
114
1048
123
1111
1.11
0.52
1.5
2.4
3.49
3.72
g/l
1.46
114
1049
461
4391
1.06
0.52
1.9
1.9
1.31
1.45
%
4.78
416
3912
10
66
1.52
0.52
1.0
1.1
—
—
—
0
0
16
215
0.74
0.52
1.6
1.9
1.00
1.56
u/field
0.69
11
124
119
1076
1.11
0.50
1.8
2.1
96.03
94.70
%
0.28
112
1032
74
650
1.14
0.50
1.2
1.5
—
16.48
—
0
15
12
84
1.43
0.49
1.0
1.1
28.12
38.62
iu/ml
0.38
12
84
11
155
0.71
0.48
1.2
1.6
1.55
2.23
u/field
0.25
11
115
7
46
1.52
0.48
1.0
1.0
—
—
—
0
0
43
363
1.19
0.48
1.1
1.2
—
—
—
0
0
78
879
0.88
0.48
2.6
3.7
36.61
56.57
mg/l
1.29
59
747
205
1909
1.08
0.47
7.3
9.3
24.76
24.88
mmol/l
0.22
205
1901
18
232
0.77
0.45
1.4
1.5
—
—
—
0
0
137
1491
0.92
0.45
1.8
1.8
0.33
0.33
mg/l
0.04
67
775
19
147
1.29
0.45
1.0
1.1
165.62
175.90
iu/ml
0.10
19
147
70
619
1.13
0.45
1.5
1.7
—
—
—
0
0
111
1009
1.10
0.44
1.6
1.7
303.24
295.70
mu/l
0.08
101
923
53
609
0.87
0.44
4.0
2.7
1.32
1.49
mmol/l
1.31
53
589
28
340
0.82
0.44
1.3
1.4
277.14
279.19
mosm/kgh2o
0.20
22
275
85
763
1.12
0.43
3.5
4.2
3.90
3.87
mmol/l
0.23
85
756
14
104
1.35
0.43
1.4
1.2
—
—
—
0
0
23
284
0.81
0.42
1.6
1.5
1532.94
2619.45
e6/l
0.85
16
194
6
91
0.66
0.42
1.0
1.1
—
—
—
0
0
10
70
1.43
0.41
2.2
2.2
16.66
18.44
umol/l
—
10
70
0
15
0.00
0.41
0.0
1.3
—
24.67
—
0
6
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
6.7
—
420.47
—
0
15
26
315
0.82
0.40
1.5
1.4
1089.05
1209.73
mu/l
0.23
18
208
0
17
0.00
0.40
0.0
9.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
177
1654
1.07
0.40
3.2
3.5
24.11
24.39
mmol/l
0.60
177
1637
334
3185
1.05
0.39
4.2
5.0
230.00
241.39
u/l
1.03
320
3037
124
1142
1.09
0.39
1.8
1.8
1.57
1.57
g/l
0.00
104
990
69
616
1.12
0.39
1.5
1.6
—
—
—
0
0
120
1301
0.92
0.38
4.2
3.1
1.02
1.02
ratio
0.05
107
1181
295
2807
1.06
0.38
9.0
9.6
124.22
123.08
g/l
0.45
290
2750
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
12
159
0.75
0.38
1.2
1.1
—
—
—
0
0
5
36
1.39
0.38
1.2
1.1
—
—
—
0
0
82
742
1.11
0.38
1.4
1.5
—
—
—
0
0
70
779
0.90
0.38
1.3
1.3
—
—
—
0
0
23
188
1.22
0.37
1.3
1.4
16.40
22.76
u/ml
—
5
33
49
430
1.14
0.37
1.2
1.1
—
—
—
0
0
15
116
1.29
0.37
1.8
1.8
—
—
—
0
0
28
332
0.84
0.36
2.3
1.9
—
—
—
0
0
23
278
0.83
0.36
1.9
1.7
—
—
—
0
0
21
171
1.23
0.35
8.8
8.0
28.20
52.98
u/ml
—
5
45
121
1122
1.08
0.35
3.5
5.5
0.84
0.89
%
0.92
115
1059
27
227
1.19
0.34
1.1
1.3
9.13
9.39
mmol/l
0.13
27
214
59
528
1.12
0.34
1.2
1.3
—
—
—
0
0
21
172
1.22
0.34
1.7
1.6
—
—
—
0
0
6
45
1.33
0.33
2.8
5.8
—
499.00
—
0
5
81
739
1.10
0.33
2.2
1.8
4966.37
2490.36
u/l
0.31
20
235
61
548
1.12
0.33
1.0
1.1
118.96
117.11
%
0.23
56
506
20
164
1.22
0.32
1.5
1.3
—
—
—
0
0
93
856
1.09
0.32
1.6
1.4
—
—
—
0
0
19
155
1.23
0.32
1.5
1.7
—
—
—
0
0
26
220
1.18
0.31
1.5
1.6
—
—
—
0
0
63
570
1.11
0.31
1.0
1.1
—
—
—
0
0
19
156
1.22
0.31
3.2
1.9
8.46
5.62
ug/l
—
10
106
23
193
1.19
0.30
1.3
1.1
—
—
—
0
0
216
2056
1.05
0.30
1.7
1.7
—
—
—
0
0
60
543
1.11
0.30
1.3
1.2
3.67
4.66
u/ml
0.35
27
232
59
535
1.10
0.29
1.2
1.1
0.97
1.07
—
6
24
21
176
1.19
0.28
1.2
1.4
26.36
30.04
umol/l
1.12
16
162
110
1028
1.07
0.28
2.1
2.5
182.27
475.49
ug/l
2.50
102
966
25
214
1.17
0.27
6.3
7.1
2.85
193.07
ug/l
1.11
13
134
68
623
1.09
0.27
1.4
1.5
—
—
—
0
0
74
803
0.92
0.27
1.9
1.6
6417.26
11370.34
e6/l
0.94
47
558
72
781
0.92
0.26
2.2
3.6
6.70
3.39
ratio
0.26
37
430
138
1305
1.06
0.26
2.0
1.6
36.12
14.66
iu/ml
—
5
32
28
244
1.15
0.25
2.8
2.4
1.21
1.20
mmol/l
0.34
28
238
120
1130
1.06
0.25
3.1
3.8
152.58
1689.98
u/ml
1.08
107
986
16
132
1.21
0.25
1.3
1.3
0.29
0.29
g/l
—
10
109
48
435
1.10
0.25
6.7
6.2
382.31
365.44
umol/l
0.39
42
391
21
179
1.17
0.25
1.7
1.6
—
—
—
0
0
197
1885
1.05
0.24
11.6
11.2
0.63
0.64
%
0.04
197
1872
22
189
1.17
0.24
1.3
1.2
—
—
—
0
0
6
81
0.74
0.24
1.0
1.1
—
—
—
0
0
6
82
0.73
0.24
1.0
1.1
—
—
—
0
0
19
161
1.18
0.24
1.4
1.3
9.00
11.01
u/l
0.70
14
151
6
83
0.72
0.24
1.0
1.1
—
—
—
0
0
446
4581
0.97
0.24
1.9
1.9
—
—
—
0
0
28
246
1.14
0.23
1.0
1.2
—
—
—
0
0
13
158
0.82
0.23
1.0
1.1
—
—
—
0
0
46
418
1.10
0.23
3.7
2.7
3.68
370.17
u/ml
0.68
46
413
516
5039
1.03
0.22
2.6
2.6
14.68
13.83
umol/l
1.99
480
4754
36
323
1.12
0.22
5.2
5.5
235.62
59.97
u/ml
0.76
13
106
30
337
0.89
0.22
1.3
1.2
—
—
—
0
0
5
41
1.22
0.22
1.0
1.1
—
—
—
0
0
63
584
1.08
0.21
3.5
7.5
104.84
105.15
mmol/l
0.18
57
526
32
286
1.12
0.21
5.2
4.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
270.70
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
68
633
1.08
0.21
1.3
1.2
306.33
283.24
u/ml
0.19
42
389
(46236287) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Pleural fluid by Immunoassay
0
12
0.00
0.21
0.0
1.3
—
6000.00
—
0
7
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
7.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
88.43
—
0
7
266
2575
1.04
0.20
8.6
8.5
8.41
8.93
mmol/l
0.74
259
2490
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
128
1342
0.95
0.20
4.5
3.8
49.08
49.49
%
0.07
128
1319
17
197
0.86
0.19
1.5
1.4
59.66
60.38
ug/l
—
9
136
19
165
1.15
0.19
1.3
1.8
—
—
—
0
0
28
251
1.12
0.18
2.8
2.3
4.11
4.01
mmol/l
0.56
28
245
28
251
1.12
0.18
2.7
2.3
107.04
105.48
mmol/l
0.85
28
245
54
503
1.07
0.17
1.4
1.5
—
—
—
0
0
34
310
1.10
0.17
3.3
2.3
15.67
21.33
mg/l
0.40
12
122
331
3232
1.03
0.16
1.8
1.8
—
—
—
0
0
154
1596
0.96
0.16
1.6
1.7
—
—
—
0
0
36
331
1.09
0.16
1.6
1.5
—
—
—
0
0
201
1949
1.03
0.16
11.3
10.9
1.33
1.35
%
0.05
201
1936
13
111
1.17
0.15
1.1
1.0
—
—
—
0
0
17
193
0.88
0.15
1.5
1.3
—
—
—
0
0
17
193
0.88
0.15
1.5
1.3
1.11
1.32
ratio
—
7
107
17
193
0.88
0.15
1.5
1.3
0.79
0.98
ratio
—
7
107
17
193
0.88
0.15
1.5
1.3
1.22
1.17
ratio
—
7
107
10
119
0.84
0.15
1.1
1.5
—
—
—
0
0
36
332
1.09
0.15
1.6
1.5
—
—
—
0
0
14
121
1.16
0.15
3.9
3.4
0.96
1.36
%
0.35
14
121
46
492
0.93
0.15
4.1
2.9
7.41
7.35
mmol/l
0.05
46
475
128
1233
1.04
0.14
3.4
5.1
1.71
1.68
%
0.11
121
1171
21
188
1.12
0.14
1.6
2.0
85.38
103.51
ng/l
0.67
21
188
9
83
1.08
0.14
1.1
1.1
—
—
—
0
0
36
333
1.08
0.14
1.6
1.5
—
—
—
0
0
91
871
1.05
0.14
1.3
1.2
—
—
—
0
0
30
326
0.92
0.14
2.7
1.9
48.51
24.14
ug/l
0.53
30
319
18
160
1.13
0.14
1.3
1.7
3.88
7.63
umol/l
1.72
12
108
49
521
0.94
0.13
1.1
1.1
218.97
21667.35
iu/ml
—
7
108
8
99
0.81
0.13
1.3
1.1
—
—
—
0
0
60
568
1.06
0.13
1.6
1.5
—
—
—
0
0
51
541
0.94
0.13
1.2
1.2
23.81
29.45
u/l
0.30
45
469
58
549
1.06
0.13
1.4
1.6
—
—
—
0
0
9
109
0.83
0.13
4.7
2.8
0.60
0.60
mmol/l
—
9
109
9
109
0.83
0.13
1.9
1.7
8.13
8.83
ug/l
—
9
109
72
687
1.05
0.13
3.1
2.0
0.83
0.87
nmol/l
0.23
65
601
178
1733
1.03
0.12
12.1
11.3
24.26
24.32
mmol/l
0.10
173
1714
473
4660
1.02
0.12
2.7
2.5
2.33
2.36
g/l
0.66
440
4364
81
844
0.96
0.12
1.5
1.3
1.20
2.86
u/ml
—
8
54
327
3330
0.98
0.12
8.7
8.7
12.92
12.72
kpa
0.27
314
3225
327
3330
0.98
0.12
8.7
8.7
5.10
5.11
kpa
0.07
314
3228
723
7309
0.99
0.11
2.3
2.3
—
—
—
0
0
22
201
1.10
0.11
1.3
1.3
133.33
133.14
nmol/l
0.01
22
201
61
639
0.95
0.11
1.4
1.5
—
—
—
0
0
80
832
0.96
0.11
1.8
1.7
—
—
—
0
0
83
799
1.04
0.11
1.7
1.7
—
—
—
0
0
18
198
0.91
0.10
1.2
1.2
8.72
10.30
mm/h
0.42
18
198
38
360
1.06
0.09
1.1
1.1
—
—
—
0
0
38
360
1.06
0.09
1.5
1.4
—
—
—
0
0
27
288
0.94
0.08
1.7
1.4
3289.80
112705.53
e6/l
2.03
15
195
7
65
1.08
0.08
1.3
1.6
—
0.76
—
0
5
21
195
1.08
0.08
1.7
1.5
—
—
—
0
0
7
66
1.06
0.08
1.6
1.6
1.19
1.19
mmol/l
—
7
66
7
66
1.06
0.08
1.3
1.1
—
—
—
0
0
6
75
0.80
0.07
1.2
1.4
—
—
—
0
0
31
294
1.05
0.07
1.3
1.5
—
—
—
0
0
7
83
0.84
0.07
1.1
1.4
46.20
61.63
ug/l
—
7
83
334
3302
1.01
0.07
8.4
8.7
0.89
0.92
mmol/l
0.06
286
2755
8
90
0.89
0.06
1.0
1.3
—
—
—
0
0
152
1546
0.98
0.06
3.2
3.3
1.99
1.73
mmol/l
0.40
116
1182
14
151
0.93
0.05
1.3
1.3
—
—
—
0
0
271
2683
1.01
0.05
3.6
3.6
1.65
1.87
mmol/l
0.47
253
2365
300
2972
1.01
0.05
8.9
9.2
95.95
96.00
%
0.04
294
2880
194
1964
0.99
0.05
12.0
11.0
93.93
94.21
%
0.19
194
1956
28
268
1.05
0.04
1.7
2.7
—
—
—
0
0
14
130
1.08
0.04
1.1
1.1
—
—
—
0
0
431
4283
1.01
0.04
2.8
2.6
25.51
23.66
%
2.03
402
4024
10
109
0.92
0.04
1.1
1.1
1.25
9.40
u/ml
—
5
72
19
180
1.06
0.04
1.2
1.1
1250.00
1503.04
miu/ml
0.59
19
180
14
131
1.07
0.03
1.4
1.2
—
—
—
0
0
68
693
0.98
0.03
8.7
6.4
2407.54
377.18
iu/ml
0.44
13
99
226
2275
0.99
0.02
2.7
2.8
73.87
71.79
e9/l
0.31
164
1667
93
919
1.01
0.02
3.4
3.9
1.31
1.35
mmol/l
0.18
93
904
106
1049
1.01
0.02
1.3
1.3
71.82
171.79
titre
1.14
11
106
169
1678
1.01
0.02
10.0
11.5
16.44
16.19
%
0.54
164
1625
12
113
1.06
0.01
1.5
1.4
—
—
—
0
0
12
113
1.06
0.01
1.5
1.4
—
—
—
0
0
23
223
1.03
0.01
1.5
1.4
—
—
—
0
0
36
353
1.02
0.01
1.6
1.4
—
—
—
0
0
11
116
0.95
0.00
1.4
1.7
—
—
—
0
0
13
124
1.05
0.00
2.0
2.1
—
178.43
—
0
28
13
124
1.05
0.00
1.8
1.5
86.46
88.36
nmol/24h
0.04
13
124
13
132
0.98
0.00
1.2
1.3
5.79
6.07
mmol/l
0.62
13
126
15
148
1.01
0.00
1.4
1.3
—
—
—
0
0
11
115
0.96
0.00
1.5
1.4
—
—
—
0
0
11
115
0.96
0.00
1.5
1.4
—
—
—
0
0
50
498
1.00
0.00
1.6
1.2
17.00
11.89
u/ml
—
5
23
55
548
1.00
0.00
2.0
1.9
—
—
—
0
0
108
1082
1.00
0.00
1.3
1.3
203.82
205.83
miu/ml
0.02
41
529
15
151
0.99
0.00
1.4
1.3
—
—
—
0
0
17
169
1.01
0.00
1.1
1.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
84
839
1.00
0.00
4.1
3.2
0.46
0.34
iu/ml
1.80
39
451
36
356
1.01
0.00
1.6
1.4
—
—
—
0
0
32
317
1.01
0.00
1.6
1.5
—
—
—
0
0
5
58
0.86
0.00
1.2
2.7
21.00
4.64
ug/l
—
5
58
5
54
0.93
0.00
1.2
1.2
—
—
—
0
0
7
74
0.95
-0.00
1.1
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_PRESBYOPIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PRESBYOPIA | 1.379 [1.18, 1.61] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.285 |
During the follow-up period (1.1.1998 — 31.12.2019), 328 out of 3648 females with H7_PRESBYOPIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PRESBYOPIA | 1.398 [1.2, 1.63] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 432 out of 2916 males with H7_PRESBYOPIA died.
Mortality risk
Mortality risk for people of age
years, who have H7_PRESBYOPIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.137% | 0.295% |
| 5 | 0.843% | 1.703% |
| 10 | 2.094% | 4.247% |
| 15 | 4.011% | 8.649% |
| 20 | 7.218% | 14.601% |
Relationships between endpoints
↥Index endpoint: H7_PRESBYOPIA – Presbyopia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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