No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
914 |
4. Check minimum number of eventsNone |
914 |
5. Include endpointsNone |
914 |
6. Filter based on genotype QC (FinnGen only) |
835 |
Control definitions (FinnGen only)
- Control exclude
- H7_EYEOTH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Anomalies of pupillary function
based on the number of shared cases.
Similar with more cases:
- Other disorders of eye and adnexa
- Diseases of the eye and adnexa
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5859 | 3670 | 2172 |
| Only index persons | 5135 | 3304 | 1831 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.11 | 0.06 |
| Only index persons | 0.10 | 0.12 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 38.54 | 40.94 | 34.48 |
| Only index persons | 41.34 | 42.94 | 38.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 835 | 600 | 235 |
| Unadjusted period prevalence (%) | 0.18 | 0.21 | 0.11 |
| Median age at first event (years) | 47.19 | 46.57 | 48.79 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 862
- Matched controls
- 8620
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H57.0
ICD-10 Finland
Anomalies of pupillary function
+∞
307.7
835
*
AA1AD
NOMESCO Finland
CT of head and brain
2.7
39.7
299
1409
G90.2
ICD-10 Finland
Horner syndrome
46.2
36.3
44
10
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.7
32.9
222
978
H57.1
ICD-10 Finland
Ocular pain
5.4
32.3
66
130
XCK00
NOMESCO Finland
Perimetry
3.8
22.7
72
201
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.0
21.2
103
376
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.9
20.7
104
386
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
4.5
20.1
50
116
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.7
18.8
109
436
R51.80
ICD-10 Finland
Headache
2.2
18.1
192
1007
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.6
17.3
113
480
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
4.2
16.8
46
115
R42
ICD-10 Finland
Dizziness and giddiness
2.1
16.8
209
1161
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.5
15.7
103
438
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
15.0
387
2705
M79.6
ICD-10 Finland
Pain in limb
1.7
14.3
410
2943
R20.2
ICD-10 Finland
Paraesthesia of skin
2.6
14.0
87
359
Q13.2
ICD-10 Finland
Other congenital malformations of iris
30.6
13.9
18
6
F29
ICPC
Eye symptom/complaint other
2.3
13.6
118
567
H53.1
ICD-10 Finland
Subjective visual disturbances
2.6
13.6
80
322
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
3.8
12.8
39
106
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
12.5
206
1246
H53.2
ICD-10 Finland
Diplopia
3.5
11.8
40
117
H53.9
ICD-10 Finland
Visual disturbance, unspecified
3.1
11.5
49
165
37834
ICD-8 Finland
Other diseases of eye, Deformatio pupillae. Anisocoria. Miosis. Mydriasis
+∞
11.5
11
*
PA6AD
NOMESCO Finland
CT of neck arteries
3.3
11.4
44
140
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
10.9
349
2525
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
10.6
252
1685
A02BC02
ATC
pantoprazole; systemic
1.6
10.6
556
4529
N06AX26
ATC
vortioxetine; oral
2.2
10.6
92
441
N06AX11
ATC
mirtazapine; oral
1.6
10.5
305
2150
R01AD58
ATC
fluticasone, combinations; nasal
1.7
9.9
253
1721
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.3
9.8
37
116
R06.0
ICD-10 Finland
Dyspnoea
1.7
9.8
224
1480
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.5
9.5
59
244
R02
ICPC
Shortness of breath/dyspnoea
1.9
9.4
121
672
L01
ICPC
Neck symptom/complaint
1.8
9.4
163
995
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
9.3
331
2433
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.2
9.2
77
363
N06AX16
ATC
venlafaxine; oral
1.8
9.2
145
859
TAB00
NOMESCO Finland
Lumbar puncture
2.6
9.1
51
200
R52.9
ICD-10 Finland
Pain, unspecified
2.0
9.1
102
540
S06.0
ICD-10 Finland
Concussion
2.0
9.0
108
584
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
8.9
125
713
R03AC02
ATC
salbutamol; inhalant
1.6
8.9
491
3970
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
12.7
8.9
15
12
R55
ICD-10 Finland
Syncope and collapse
2.1
8.8
91
468
A02BC05
ATC
esomeprazole; systemic
1.6
8.7
326
2415
H02.4
ICD-10 Finland
Ptosis of eyelid
3.3
8.5
31
95
H20.1
ICD-10 Finland
Chronic iridocyclitis
6.5
8.5
21
33
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
8.5
175
1118
A02BA02
ATC
ranitidine; systemic
1.8
8.5
141
847
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.8
8.4
136
810
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
3.8
8.1
24
64
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
8.1
220
1509
PA6CG
NOMESCO Finland
Extensive MRI examination of neck vasculature with high intensity magnet
17.4
8.1
12
7
SPAT1301
SPAT
No procedures
1.6
7.9
250
1774
F41.09
ICD-10 Finland
UNS Panic Syndrome
2.8
7.8
38
139
N02BE01
ATC
paracetamol; systemic, rectal
1.8
7.8
750
6794
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.1
7.7
74
370
M01AB05
ATC
diclofenac; systemic, rectal
1.5
7.7
535
4484
N05AH04
ATC
quetiapine; oral
1.7
7.6
169
1100
S16
ICPC
Bruise/contusion
3.0
7.6
32
108
P06
ICPC
Sleep disturbance
1.8
7.5
124
742
H04.10
ICD-10 Finland
Dry eye syndrome
1.8
7.5
109
628
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.8
7.5
118
697
R03DC03
ATC
montelukast; oral
1.7
7.5
151
958
L17
ICPC
Foot/toe symptom/complaint
1.5
7.2
262
1914
J01AA02
ATC
doxycycline; systemic
1.5
7.1
614
5333
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.9
7.1
93
518
N03AX12
ATC
[U] gabapentin; oral
1.7
7.1
129
794
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
7.0
217
1527
PA7BD
NOMESCO Finland
CT angiography of neck and brain
4.4
7.0
17
39
F10.09
ICD-10 Finland
Alcohol intoxication UNS
3.4
6.9
24
72
K04.0
ICD-10 Finland
Pulpitis
1.8
6.8
96
548
G44.2
ICD-10 Finland
Tension-type headache
1.7
6.8
133
836
G44.0
ICD-10 Finland
Cluster headache syndrome
4.3
6.8
17
40
W00
ICD-10 Finland
Fall on same level involving ice and snow
1.8
6.8
97
557
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
6.7
347
2717
WX720
NOMESCO Finland
Own respiration
2.4
6.7
44
188
SPAT1260
SPAT
Consultation of another employee
1.7
6.6
139
890
H02AB06
ATC
prednisolone; systemic
1.5
6.6
363
2873
A01
ICPC
Pain general/multiple sites
1.9
6.5
89
504
M25.5
ICD-10 Finland
Pain in joint
1.5
6.5
290
2203
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.1
6.5
61
303
PA6AG
NOMESCO Finland
Limited MRI examination of neck vasculature with high intensity magnet
7.5
6.4
14
19
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
6.4
234
1704
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
6.4
356
2817
R06AX27
ATC
desloratadine; oral
1.5
6.4
269
2017
K80
ICPC
Cardiac arrhythmia NOS
2.0
6.4
74
396
N06AB04
ATC
citalopram; systemic
1.6
6.4
167
1129
R51
ICD-10 Finland
Headache
2.1
6.4
61
305
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.4
6.3
43
186
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
3.4
6.3
22
66
T74.1
ICD-10 Finland
Physical abuse
3.1
6.2
25
82
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.3
6.2
44
194
L29.9
ICD-10 Finland
Pruritus, unspecified
2.9
6.2
29
104
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
6.2
157
1053
Z71.8
ICD-10 Finland
Other specified counselling
1.5
6.2
306
2366
WX702
NOMESCO Finland
Supraglottic ventilation device
2.1
6.1
54
261
N17
ICPC
Vertigo/dizziness
1.7
6.1
106
643
UJF32
NOMESCO Finland
Coloscopy
1.6
6.0
180
1253
R60.0
ICD-10 Finland
Localized oedema
1.8
6.0
95
561
J01DB01
ATC
cefalexin; oral
1.6
6.0
695
6278
J01MA02
ATC
ciprofloxacin; systemic
1.5
6.0
273
2073
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
351
2129
2.09
23.54
2.3
2.2
162.48
201.15
u/l
0.56
336
2022
191
1052
2.05
15.63
2.2
2.1
29.29
29.32
s
0.02
184
1023
472
3503
1.77
14.81
7.7
7.2
1.21
1.22
mmol/l
0.91
413
3045
549
4261
1.79
14.72
6.0
5.1
6.33
6.57
mmol/l
2.23
518
3978
434
3150
1.76
14.67
7.0
6.6
1.20
1.22
mmol/l
2.66
404
2917
418
3017
1.75
14.28
11.6
10.9
1.15
1.17
inr
0.39
343
2488
670
5592
1.89
13.40
4.7
4.2
10.47
10.80
mm/h
0.26
640
5242
419
3065
1.71
13.33
4.7
4.8
36.52
36.35
g/l
0.27
400
2912
657
5625
1.71
9.96
8.8
7.7
75.93
78.22
u/l
0.78
637
5341
182
1132
1.77
9.85
1.8
1.9
—
—
—
0
0
480
3814
1.58
9.80
6.6
6.3
12.17
10.99
umol/l
0.34
450
3633
48
177
2.81
9.66
1.1
1.5
407.35
110.88
e6/l
0.57
37
133
811
7454
2.49
9.57
19.8
15.5
139.57
139.66
mmol/l
0.48
802
7302
812
7469
2.50
9.53
19.9
15.6
3.93
3.94
mmol/l
0.53
801
7298
540
4426
1.59
9.52
10.1
9.4
3.95
4.04
e9/l
0.46
470
3872
47
173
2.82
9.49
1.1
1.4
4.91
14.81
e6/l
0.75
32
125
143
839
1.84
9.36
1.7
1.8
—
—
—
0
0
316
2300
1.59
9.27
2.8
2.6
56.19
61.22
u/l
0.85
299
2146
345
2583
1.56
8.85
3.5
3.3
34.83
72.92
ng/l
0.64
211
1628
199
1315
1.67
8.53
4.6
3.7
216.05
421.64
ng/l
0.74
137
902
23
58
4.05
8.37
1.0
1.1
—
—
—
0
0
24
63
3.89
8.29
1.0
1.1
237.96
228.26
mg/l
0.11
24
50
809
7494
2.29
8.21
17.9
13.8
21.10
22.26
mg/l
0.48
682
6089
504
4160
1.51
7.87
4.0
3.7
16.07
5.22
estimate
0.29
99
869
80
412
2.04
7.67
2.9
3.0
92.36
171.61
ng/l
2.67
74
377
122
726
1.79
7.57
8.9
9.6
12.34
12.37
kpa
0.02
116
703
122
726
1.79
7.57
9.0
9.6
5.11
5.13
kpa
0.06
116
700
692
6147
1.64
7.57
5.7
4.5
14.67
14.60
pmol/l
0.30
649
5713
132
805
1.76
7.53
1.9
1.8
—
—
—
0
0
249
1788
1.55
7.44
2.0
1.8
1.55
1.06
mg/l
0.43
180
1374
497
4117
1.49
7.44
4.1
3.7
0.00
0.00
estimate
0.50
95
855
255
1846
1.54
7.33
3.9
3.7
1.02
1.02
kg/l
0.01
161
1223
503
4186
1.48
7.29
4.1
3.7
0.03
0.02
estimate
0.13
95
820
119
714
1.77
7.17
9.0
9.7
1.26
0.88
mmol/l
0.55
101
597
94
525
1.89
7.14
3.1
3.7
4.61
4.60
pmol/l
0.02
83
464
835
7902
2.81
7.03
21.7
17.1
71.12
72.27
umol/l
0.89
829
7818
103
596
1.83
7.00
1.5
1.3
247.09
243.98
u/ml
0.01
98
552
175
1184
1.60
6.69
3.2
3.7
0.83
0.82
mmol/l
0.41
162
1122
142
917
1.66
6.54
8.9
7.6
104.04
104.30
mmol/l
0.25
142
917
170
1163
1.58
6.16
2.4
2.5
114.05
118.81
ug/g
0.07
135
922
768
7105
1.74
6.08
7.0
5.5
1.87
1.84
mu/l
0.31
726
6681
338
2673
1.44
6.00
3.8
3.2
31.60
30.65
u/l
0.19
321
2540
60
307
2.03
5.89
1.4
1.4
—
—
—
0
0
385
3137
1.41
5.70
2.1
2.0
100.79
97.26
pmol/l
0.80
207
1661
279
2156
1.43
5.53
1.4
1.4
0.81
1.87
u/ml
2.30
67
615
474
4017
1.40
5.51
3.2
3.2
103.57
94.14
ug/l
0.32
452
3802
262
2009
1.44
5.39
1.6
1.6
20.10
20.81
nmol/l
0.35
228
1723
251
1911
1.44
5.36
1.8
1.7
—
—
—
0
0
101
630
1.68
5.29
2.8
3.1
10.39
10.48
g/l
0.09
95
582
255
1956
1.43
5.21
2.3
2.2
2.28
2.81
mg/l
4.44
226
1699
18
55
3.32
5.05
1.1
1.3
0.59
0.58
ratio
0.04
12
27
758
7059
1.61
4.97
4.9
4.6
5.79
5.80
mmol/l
0.11
708
6552
48
242
2.04
4.94
2.3
2.2
5.12
4.19
iu/l
0.18
24
103
416
3493
1.37
4.89
2.5
2.5
74.40
75.63
nmol/l
0.42
389
3202
241
1849
1.42
4.87
5.0
4.0
92.98
93.50
%
0.12
235
1807
31
134
2.36
4.64
1.6
1.4
—
—
—
0
0
309
2490
1.38
4.64
3.1
3.3
2.35
2.36
mmol/l
0.92
286
2279
20
69
2.94
4.62
1.1
1.3
2.05
0.30
u/ml
1.18
14
37
23
86
2.72
4.61
1.0
1.1
—
—
—
0
0
17
54
3.19
4.50
1.1
1.1
1.33
1.12
u/l
—
7
25
21
77
2.77
4.37
1.0
1.1
—
—
—
0
0
823
7881
1.98
4.32
13.8
11.1
26.05
25.87
u/l
0.10
805
7688
234
1826
1.39
4.21
2.8
3.2
926.86
924.43
ng/l
0.00
189
1521
20
73
2.78
4.21
1.1
1.1
14.22
5.40
iu/ml
—
9
20
99
655
1.58
4.12
2.2
2.6
0.22
0.22
g/l
0.02
92
624
189
1430
1.41
4.06
1.7
1.7
439.41
27536664.21
pmol/l
1.57
162
1242
254
2019
1.37
4.06
3.6
3.0
0.20
0.36
e6/l
1.18
176
1458
849
8246
2.96
4.04
27.0
21.1
4.50
4.51
e12/l
0.44
839
8090
178
1337
1.42
3.98
2.7
2.5
2.43
2.44
mmol/l
0.27
159
1195
28
126
2.26
3.87
1.1
1.1
0.86
2.13
—
5
26
101
683
1.54
3.82
4.3
4.2
2.00
1.76
mmol/l
0.30
89
572
848
8243
2.77
3.81
27.2
21.1
258.65
257.46
e9/l
0.22
840
8103
205
1591
1.38
3.77
1.4
1.3
20.79
28.33
iu/ml
1.02
70
478
63
382
1.70
3.71
1.7
1.7
—
—
—
0
0
165
1240
1.41
3.66
3.5
2.7
1.19
1.03
e6/l
0.15
82
625
43
234
1.88
3.62
1.5
2.0
131.19
304.43
ug/l
2.58
43
223
106
734
1.51
3.60
4.0
2.4
32.08
99.26
u/l
0.51
91
613
697
6483
1.39
3.58
21.9
17.0
13.40
13.45
%
0.65
689
6414
92
620
1.54
3.55
9.9
9.2
1.39
1.33
mmol/l
0.16
87
611
370
3155
1.30
3.54
3.7
3.6
6.58
0.03
estimate
0.49
76
718
13
36
3.65
3.50
1.0
1.3
—
87.50
%
—
0
6
43
237
1.86
3.49
1.3
1.1
3.88
4.48
—
6
37
601
5476
1.32
3.46
4.0
3.5
—
—
—
0
0
283
2333
1.32
3.45
3.9
3.1
17.32
87.71
e6/l
1.71
210
1760
370
3164
1.30
3.44
2.0
1.9
1.39
1.36
mmol/l
0.34
318
2737
20
82
2.47
3.40
1.1
1.1
—
—
—
0
0
77
506
1.57
3.32
2.0
2.5
12.78
12.45
nmol/l
0.09
72
475
36
191
1.92
3.29
2.6
2.9
0.75
2.11
index
1.85
19
100
67
1015
0.63
3.28
1.9
1.9
3.74
3.45
ratio
0.95
49
789
117
844
1.45
3.25
2.8
3.0
9.37
6.42
umol/l
0.28
100
740
62
390
1.64
3.21
1.4
1.4
237.05
243.95
miu/ml
0.07
29
200
154
1172
1.38
3.16
2.1
2.5
13.14
13.42
umol/l
0.18
144
1090
101
712
1.47
3.16
4.4
4.1
5.98
5.79
kpa
1.18
95
688
125
922
1.42
3.08
5.2
6.1
1.07
1.06
mmol/l
0.04
118
864
150
1142
1.38
3.07
3.8
2.9
2.80
3.16
e6/l
0.23
63
529
187
1474
1.34
3.07
1.3
1.3
10.59
9.76
u/ml
0.05
74
571
46
275
1.71
2.90
1.2
1.5
0.01
0.10
iu/ml
—
6
38
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
31
164
1.92
2.88
4.4
3.4
0.35
0.35
iu/ml
0.01
17
86
23
110
2.12
2.80
1.7
1.3
—
—
—
0
0
5
6
8.37
2.75
1.0
1.2
—
—
—
0
0
97
701
1.43
2.69
1.2
1.3
110.75
143.51
u/ml
0.44
41
290
15
61
2.48
2.63
3.1
2.2
37.38
33.09
mg/l
—
8
44
12
41
2.95
2.62
1.0
1.0
22.57
36.95
ng/l
—
7
27
12
41
2.95
2.62
1.0
1.0
831.71
725.86
ng/l
—
7
29
12
41
2.95
2.62
1.0
1.0
217.14
287.55
ng/l
—
7
29
196
1590
1.30
2.61
2.6
2.5
5.72
7.06
e6/l
0.88
182
1443
103
759
1.41
2.57
5.5
6.2
—
—
—
0
0
43
262
1.67
2.56
1.5
1.3
—
—
—
0
0
6
11
5.48
2.54
1.3
1.1
—
—
—
0
0
11
37
3.00
2.49
1.0
1.1
—
—
—
0
0
27
144
1.90
2.48
1.2
1.1
—
—
—
0
0
582
5379
1.25
2.47
3.5
3.3
47.03
43.07
u/l
0.34
551
5128
275
2342
1.26
2.46
3.1
3.1
0.00
0.01
estimate
1.54
77
702
72
501
1.48
2.44
1.7
1.6
—
—
—
0
0
107
801
1.38
2.44
1.9
2.1
383.39
380.85
nmol/l
0.05
94
757
132
1022
1.34
2.44
1.8
1.7
1121.37
1197.78
nmol/l
0.53
102
785
401
3564
1.23
2.43
2.7
2.7
—
—
estimate
—
0
0
771
7396
1.40
2.43
5.7
5.3
2.79
2.78
mmol/l
0.15
724
6972
0
65
0.00
2.42
0.0
2.1
—
2.12
—
0
41
719
6826
1.32
2.41
6.0
5.8
38.21
38.40
mmol/mol
0.22
682
6461
35
206
1.73
2.37
1.4
1.4
288.94
308.84
ug/g
0.19
17
116
23
119
1.96
2.32
2.7
2.0
13.06
13.16
%
0.21
23
119
214
1782
1.27
2.30
2.5
2.7
329.33
329.90
umol/l
0.02
189
1599
78
561
1.43
2.25
2.5
2.4
18.54
22.09
au/ml
—
8
54
54
785
0.67
2.21
1.8
1.7
3.81
3.45
mmol/l
1.01
36
553
37
227
1.66
2.18
1.1
1.3
—
—
—
0
0
7
19
3.71
2.15
1.1
1.3
—
—
—
0
0
137
1088
1.31
2.13
2.0
2.5
2.46
2.39
g/l
0.75
124
1011
762
7323
1.35
2.12
5.1
4.7
4.73
4.70
mmol/l
0.35
710
6927
30
175
1.74
2.12
1.2
1.5
—
—
—
0
0
8
25
3.22
2.10
1.0
1.4
—
—
—
0
0
7
20
3.52
2.06
2.0
2.1
38.21
43.09
g/l
—
7
20
13
56
2.34
2.05
1.8
1.6
—
—
—
0
0
13
56
2.34
2.05
2.1
3.7
—
—
—
0
0
164
1341
1.28
2.04
2.3
2.2
—
—
—
0
0
76
555
1.41
2.03
3.1
2.5
80.57
71.10
ml/min/173m2
1.29
37
243
21
111
1.91
2.02
1.3
1.2
—
—
—
0
0
118
925
1.32
2.02
2.6
2.2
—
—
—
0
0
742
7114
1.31
2.02
15.9
12.9
88.70
86.91
ml/min/173m2
1.57
687
6495
31
187
1.68
1.96
1.5
1.5
—
—
—
0
0
101
780
1.33
1.92
2.2
2.1
—
—
—
0
0
131
1051
1.29
1.90
1.9
1.8
1.51
1.45
%
0.38
117
948
70
511
1.40
1.89
1.3
1.3
85.37
32.08
au/ml
—
6
38
175
1456
1.25
1.88
2.3
2.3
—
—
—
0
0
7
22
3.20
1.88
2.0
2.1
19.37
19.49
umol/l
—
7
22
281
2464
1.21
1.83
4.4
3.4
7.39
7.71
mmol/l
0.57
240
2115
33
209
1.60
1.76
1.2
1.6
—
—
—
0
0
23
132
1.76
1.75
1.3
1.2
1.30
3.54
u/ml
—
10
50
12
54
2.24
1.74
1.1
1.3
—
28.33
—
0
6
7
24
2.93
1.72
4.7
5.6
—
—
—
0
0
5
13
3.86
1.71
6.6
9.3
6.30
5.87
kpa
—
5
13
5
13
3.86
1.71
6.6
9.2
5.10
4.95
kpa
—
5
13
23
133
1.75
1.71
1.3
1.2
2.73
5.06
u/ml
0.66
11
62
249
2172
1.21
1.70
4.1
4.2
12.47
8.57
mg/mmol
0.42
146
1348
24
141
1.72
1.69
1.2
1.4
—
—
—
0
0
11
49
2.26
1.64
1.0
1.6
—
—
—
0
0
5
14
3.59
1.61
1.0
1.4
—
—
—
0
0
12
56
2.16
1.61
1.1
1.4
—
455.00
—
0
6
755
7298
1.28
1.60
5.0
4.7
1.49
1.49
mmol/l
0.07
705
6868
36
239
1.53
1.60
1.2
1.1
3.94
8.79
eliau/ml
—
5
39
10
43
2.34
1.59
1.3
3.0
525.60
676.28
u/ml
—
10
43
7
26
2.71
1.58
1.1
1.1
63.13
53.53
iu/ml
—
7
26
35
232
1.53
1.57
1.7
1.8
—
—
—
0
0
0
44
0.00
1.51
0.0
1.9
—
1.29
—
0
35
69
524
1.34
1.50
1.0
1.0
—
—
—
0
0
35
235
1.51
1.49
1.2
1.1
3.30
3.20
u/ml
0.02
16
131
24
147
1.65
1.48
1.0
1.5
—
—
—
0
0
31
205
1.53
1.42
1.1
1.1
8.35
6.88
u/ml
0.21
13
120
36
247
1.48
1.40
3.4
6.1
1.35
1.37
mg/l
0.04
31
225
124
1030
1.24
1.37
4.8
4.1
20.83
21.90
%
0.28
54
445
23
358
0.63
1.37
1.0
1.2
0.93
0.90
g/l
0.18
23
358
66
506
1.33
1.37
2.2
2.3
5761.07
5914.30
u/l
0.01
26
215
30
199
1.53
1.36
3.1
2.6
—
—
—
0
0
44
316
1.41
1.36
1.8
1.7
—
—
—
0
0
30
200
1.52
1.34
1.2
1.6
—
—
—
0
0
68
526
1.32
1.33
2.1
3.7
1.23
1.23
mmol/l
0.44
60
458
30
201
1.51
1.31
1.2
1.1
3.08
1.84
u/ml
0.18
13
109
54
405
1.36
1.30
1.9
1.7
0.34
0.33
mg/l
0.06
33
185
72
564
1.30
1.29
2.1
2.4
0.43
0.27
e6/l
0.56
66
533
8
34
2.37
1.29
1.3
1.1
—
—
—
0
0
34
235
1.47
1.29
4.6
3.0
2591.65
1073.30
u/ml
0.25
34
206
23
347
0.65
1.21
1.0
1.1
1.50
1.55
g/l
0.50
23
347
716
6927
1.20
1.21
4.1
4.0
1.25
1.26
mmol/l
0.11
664
6475
25
165
1.53
1.18
1.3
1.5
131.80
151.01
au/ml
—
5
49
68
537
1.29
1.17
3.4
3.9
70.42
76.08
ng/l
0.34
62
483
210
1863
1.17
1.16
1.6
1.5
2.08
2.23
g/l
0.77
136
1174
96
793
1.24
1.14
3.6
3.0
0.66
0.80
ug/l
1.04
65
452
35
250
1.42
1.14
1.7
2.0
—
—
—
0
0
41
305
1.36
1.07
1.6
1.6
6.65
9.23
u/ml
0.32
11
72
5
22
2.28
1.03
1.2
1.2
—
—
—
0
0
250
2266
1.15
1.03
4.2
3.8
0.00
0.01
estimate
1.23
92
822
150
1313
1.17
0.99
6.4
4.7
2.72
2.26
ug/l
0.29
130
1196
22
148
1.50
0.98
1.1
1.1
0.37
0.40
u/ml
—
6
51
24
342
0.69
0.98
1.6
1.5
—
—
—
0
0
60
479
1.27
0.98
2.7
2.2
10.04
7.28
ug/l
0.25
50
431
53
663
0.79
0.93
1.6
1.6
870.82
975.53
mu/l
0.53
44
558
25
349
0.71
0.93
1.6
1.5
0.95
0.94
ratio
0.05
15
221
25
349
0.71
0.93
1.6
1.5
0.99
1.21
ratio
1.04
15
221
25
349
0.71
0.93
1.6
1.5
1.14
1.16
ratio
0.05
15
221
20
134
1.50
0.92
1.0
1.1
—
—
—
0
0
13
78
1.68
0.92
1.2
1.7
—
—
—
0
0
182
1630
1.15
0.89
1.5
1.5
—
—
—
0
0
19
128
1.50
0.86
1.4
1.3
—
—
—
0
0
114
989
1.18
0.85
2.1
2.5
20.02
22.70
%
1.55
108
928
33
248
1.34
0.84
2.6
2.2
7.27
7.31
g/l
0.04
33
233
33
248
1.34
0.84
2.6
2.2
3.45
3.76
g/l
0.73
33
233
33
248
1.34
0.84
2.6
2.2
4.06
4.29
g/l
0.96
33
233
67
553
1.23
0.84
1.4
1.5
—
—
—
0
0
34
443
0.76
0.83
1.5
1.5
—
—
—
0
0
66
547
1.22
0.81
1.3
1.4
42.82
23.50
iu/l
1.95
49
469
0
24
0.00
0.79
0.0
1.2
—
69.42
—
0
24
0
25
0.00
0.79
0.0
1.2
—
355.94
—
0
17
80
678
1.20
0.79
3.4
3.1
—
—
—
0
0
18
123
1.47
0.78
1.1
1.2
122.67
114.20
%
0.76
18
111
30
226
1.34
0.77
1.2
1.1
—
—
—
0
0
30
227
1.33
0.75
1.2
1.1
—
—
—
0
0
31
236
1.33
0.75
2.7
2.3
2.68
2.95
g/l
1.13
31
221
7
38
1.85
0.73
1.1
2.1
65.13
118.41
ng/l
—
7
38
9
56
1.61
0.72
1.0
1.2
—
—
—
0
0
13
84
1.56
0.72
1.0
1.1
12.33
15.99
u/ml
—
6
43
199
1821
1.12
0.71
2.4
2.2
—
—
—
0
0
38
301
1.27
0.70
1.3
1.6
24.70
9.45
u/l
0.62
27
247
13
85
1.54
0.69
8.4
1.9
—
—
—
0
0
5
27
1.86
0.68
1.6
1.1
4.01
15.71
u/ml
—
5
19
15
102
1.48
0.68
1.1
1.1
—
—
—
0
0
24
181
1.34
0.63
2.9
2.3
0.00
0.00
g/l
-0.00
24
173
17
122
1.40
0.60
1.2
1.2
—
—
—
0
0
29
366
0.79
0.60
1.8
1.8
2.79
3.22
mg/l
0.16
19
272
70
610
1.16
0.54
4.6
4.4
8.89
15.20
ug/l
0.30
54
494
6
38
1.58
0.54
1.3
1.1
139.00
156.92
iu/ml
—
6
38
6
38
1.58
0.54
1.2
1.2
—
—
—
0
0
6
38
1.58
0.54
1.0
1.1
14.85
39.36
u/ml
—
6
38
11
74
1.49
0.53
1.2
1.3
—
—
—
0
0
24
187
1.29
0.53
1.3
1.4
200.58
226.99
u/ml
0.22
12
109
6
39
1.54
0.53
1.7
1.4
5.78
5.68
mmol/l
—
6
39
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
40
1.50
0.51
1.0
1.1
—
—
—
0
0
31
376
0.82
0.48
1.5
1.6
67.97
62.48
ug/l
0.23
24
313
7
50
1.40
0.45
1.0
1.1
749.00
1570.24
miu/ml
—
7
50
40
340
1.19
0.44
2.8
3.1
1.02
1.02
ratio
0.38
33
317
22
175
1.26
0.43
5.1
2.2
0.77
0.88
nmol/l
0.41
15
152
8
57
1.41
0.42
1.6
1.6
—
—
—
0
0
38
323
1.18
0.42
1.3
1.4
—
—
—
0
0
43
370
1.17
0.41
1.7
1.7
5.70
5.62
iu/ml
0.01
12
86
0
17
0.00
0.40
0.0
1.3
—
—
—
0
0
8
60
1.34
0.40
1.0
1.2
127.50
114.25
pmol/l
—
8
60
5
35
1.43
0.39
1.0
3.0
11.82
258.28
ug/l
—
5
29
0
19
0.00
0.39
0.0
2.2
—
0.09
—
0
12
5
36
1.39
0.38
1.0
1.3
—
—
—
0
0
5
36
1.39
0.38
1.0
1.3
—
—
—
0
0
12
89
1.35
0.38
1.3
1.2
—
—
—
0
0
9
68
1.33
0.37
1.1
1.8
—
—
—
0
0
9
69
1.31
0.37
1.4
1.8
—
—
—
0
0
18
145
1.25
0.34
1.7
3.4
5.66
7.19
pmol/l
1.04
18
145
26
219
1.19
0.33
2.8
2.2
10.44
10.74
g/l
0.14
26
203
6
47
1.28
0.32
1.0
1.1
—
—
—
0
0
47
420
1.13
0.30
4.2
4.0
1.59
1.69
mmol/l
0.05
39
309
7
56
1.25
0.29
1.0
1.1
—
—
—
0
0
17
139
1.23
0.29
1.1
1.1
2.22
2.40
eliau/ml
—
10
66
21
176
1.20
0.29
1.6
1.5
8776.93
13334.45
e6/l
0.45
14
123
21
177
1.19
0.27
3.0
3.6
1.15
2.24
ratio
1.46
12
99
14
113
1.24
0.26
1.0
1.5
—
—
—
0
0
5
75
0.66
0.26
1.0
1.1
—
—
—
0
0
9
72
1.25
0.25
3.4
3.8
—
—
—
0
0
53
483
1.10
0.25
1.3
1.3
—
—
—
0
0
22
189
1.17
0.24
1.6
1.6
0.34
0.34
nmol/l
0.01
15
154
16
133
1.21
0.24
2.1
3.0
7.22
7.68
mmol/l
0.35
16
128
17
200
0.85
0.23
1.1
1.3
—
—
—
0
0
24
210
1.15
0.22
3.7
4.0
1.33
1.29
mmol/l
0.07
24
205
21
241
0.87
0.21
1.5
1.6
66.37
54.61
ug/l
0.55
21
241
0
11
0.00
0.21
0.0
3.4
—
0.64
—
0
11
0
10
0.00
0.21
0.0
2.1
—
1.71
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
17
145
1.18
0.20
2.1
1.7
—
—
—
0
0
6
48
1.25
0.20
1.0
1.6
0.65
0.48
e9/l
—
6
48
6
50
1.20
0.19
1.5
1.2
3.50
8.84
mm/h
—
6
50
22
193
1.14
0.19
1.4
1.3
—
—
—
0
0
8
71
1.13
0.16
1.3
1.2
—
—
—
0
0
8
72
1.11
0.16
1.3
1.2
—
—
—
0
0
39
363
1.08
0.14
1.6
1.4
—
—
—
0
0
15
134
1.12
0.11
1.3
1.3
—
—
—
0
0
15
134
1.12
0.11
1.3
1.3
—
—
—
0
0
84
868
0.96
0.09
4.9
4.4
32.15
31.70
%
0.17
52
582
6
55
1.09
0.09
2.2
1.4
43.93
31.85
nmol/l
—
6
44
13
144
0.90
0.08
2.1
2.4
16.63
121.56
ug/min
—
7
86
8
74
1.08
0.07
1.3
1.2
—
—
—
0
0
8
74
1.08
0.07
1.3
1.2
—
—
—
0
0
8
78
1.03
0.07
1.3
1.2
—
—
—
0
0
26
275
0.94
0.07
1.6
1.8
—
—
—
0
0
9
100
0.90
0.06
1.0
1.3
—
—
—
0
0
25
264
0.95
0.06
1.3
1.3
3.90
9.19
u/ml
—
7
43
17
159
1.07
0.05
1.8
1.6
—
—
—
0
0
14
150
0.93
0.04
1.7
1.7
—
—
—
0
0
17
177
0.96
0.01
1.3
1.2
—
—
—
0
0
22
226
0.97
0.00
1.9
1.4
94.00
226.42
pmol/l
0.87
22
220
32
322
0.99
0.00
1.6
1.7
—
—
—
0
0
10
103
0.97
0.00
1.4
1.5
—
—
—
0
0
35
347
1.01
0.00
1.5
1.5
—
—
—
0
0
33
335
0.98
0.00
1.7
1.8
—
—
—
0
0
18
185
0.97
0.00
1.5
1.3
—
—
—
0
0
6
62
0.97
0.00
1.2
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
6
62
0.97
0.00
1.2
1.6
—
—
—
0
0
6
62
0.97
0.00
1.2
1.6
—
—
—
0
0
5
56
0.89
0.00
2.0
1.3
—
—
—
0
0
13
130
1.00
-0.00
1.0
1.7
—
—
—
0
0
7
73
0.96
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
1.17
—
0
6
9
96
0.94
-0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
8.56
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
10
100
1.00
-0.00
1.1
1.6
—
—
—
0
0
6
63
0.95
-0.00
1.2
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
1.44
—
0
9
9
99
0.91
-0.00
1.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
7
71
0.99
-0.00
1.4
1.2
56.43
51.48
u/l
—
7
66
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
82
0.98
-0.00
1.3
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
95
0.95
-0.00
1.0
1.3
—
—
—
0
0
7
72
0.97
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
59
0.85
-0.00
1.0
2.0
—
1315.73
—
0
12
8
81
0.99
-0.00
1.6
1.3
1.79
1.39
nmol/l
—
8
72
9
99
0.91
-0.00
1.0
1.3
—
—
—
0
0
14
140
1.00
-0.00
1.6
1.3
—
—
—
0
0
9
95
0.95
-0.00
1.0
1.3
—
—
—
0
0
5
59
0.85
-0.00
1.2
2.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_ANOMAPUPFUNC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ANOMAPUPFUNC | 1.182 [0.96, 1.46] | 0.124 |
| Birth year | 0.993 [0.98, 1.0] | 0.099 |
During the follow-up period (1.1.1998 — 31.12.2019), 169 out of 2968 females with H7_ANOMAPUPFUNC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ANOMAPUPFUNC | 1.53 [1.15, 2.03] | 0.003 |
| Birth year | 0.99 [0.98, 1.0] | 0.032 |
During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 1746 males with H7_ANOMAPUPFUNC died.
Mortality risk
Mortality risk for people of age
years, who have H7_ANOMAPUPFUNC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.131% | 0.289% |
| 5 | 0.718% | 1.814% |
| 10 | 1.711% | 4.479% |
| 15 | 3.221% | 8.656% |
| 20 | 5.523% | 14.409% |
Relationships between endpoints
↥Index endpoint: H7_ANOMAPUPFUNC – Anomalies of pupillary function
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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