hyperprolactinemia: An acquired metabolic disease that has_material_basis_in the presence of abnormally-high levels of prolactin in the blood.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1547 |
4. Check minimum number of eventsNone |
1547 |
5. Include endpointsNone |
1547 |
6. Filter based on genotype QC (FinnGen only) |
1395 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E22
- Name in latin
- Hyperprolactinaemia
Similar endpoints
↥List of similar endpoints to
Hyperprolactinaemia
based on the number of shared cases.
Similar with more cases:
- Hyperfunction of pituitary gland
- Exclusions for E4_PCOS_BROAD
- Disorders of other endocrine glands
- Exclusions for E4_PCOS_CONSORTIUM
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7858 | 6346 | 1386 |
| Only index persons | 7530 | 6218 | 1312 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.18 | 0.04 |
| Only index persons | 0.20 | 0.23 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 35.99 | 33.41 | 47.97 |
| Only index persons | 35.83 | 33.35 | 47.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1395 | 1138 | 257 |
| Unadjusted period prevalence (%) | 0.35 | 0.40 | 0.12 |
| Median age at first event (years) | 37.13 | 34.18 | 50.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1459
- Matched controls
- 14590
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E22.1
ICD-10 Finland
Hyperprolactinaemia
4503599627370496.0
307.7
1425
6
G02CB01
ATC
bromocriptine; systemic
50.7
307.7
483
141
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
206.7
307.7
359
23
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
334.4
307.7
459
20
G02CB03
ATC
cabergoline; oral
86.8
307.7
215
29
N04BC06
ATC
cabergoline; oral
1131.6
307.7
516
7
N91.1
ICD-10 Finland
Secondary amenorrhoea
13.1
171.3
171
146
H02AB09
ATC
hydrocortisone; systemic
16.0
150.2
132
90
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
51.4
110.9
64
13
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.9
97.7
242
568
N05AX08
ATC
risperidone; systemic
5.0
95.1
228
520
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
9.0
89.4
114
136
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
148.4
79.9
84
6
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
75.7
72
*
G02CB04
ATC
quinagolide; oral
700.0
68.6
67
*
N05AH03
ATC
olanzapine; systemic
4.0
65.1
206
576
N64.3
ICD-10 Finland
Galactorrhoea not associated with childbirth
13.9
63.3
59
44
G03DB01
ATC
dydrogesterone; oral
2.9
60.5
360
1485
F29
ICD-10 Finland
Unspecified nonorganic psychosis
4.9
60.5
143
319
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
58.7
56
*
N05AX12
ATC
aripiprazole; systemic
4.2
58.5
169
441
N05AB03
ATC
perphenazine; systemic, rectal
5.1
52.4
116
244
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
13.2
52.2
50
39
2531A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other and unspecified anterior pituitary hyperfunction[HYPERPROLACTINAEMIA]
+∞
51.4
49
*
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
483.0
47.6
47
*
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
78.6
47.3
53
7
N05AH02
ATC
clozapine; systemic
6.3
46.5
80
133
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.7
46.2
111
250
N05AH04
ATC
quetiapine; oral
2.4
44.1
390
1919
H03AA01
ATC
levothyroxine sodium; systemic
2.3
41.1
430
2265
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
6.2
39.6
69
116
N05AA02
ATC
levomepromazine; systemic
4.3
35.7
97
240
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
126.5
34.8
37
*
E23.05
ICD-10 Finland
Lack of TSH
344.9
34.1
34
*
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
78.1
34.0
38
5
N04AA02
ATC
biperiden; systemic
6.0
33.4
60
104
XCK00
NOMESCO Finland
Perimetry
3.8
31.8
102
285
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
31.4
30
*
F25.10
ICD-10 Finland
Schizoaffective syndrome, depressive type with only concomitant bipolar and schizophrenic symptoms
9.2
30.4
37
41
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
30.3
29
*
XLA10, ,
NOMESCO Finland
3.2
29.9
124
409
N97.0
ICD-10 Finland
Female infertility associated with anovulation
4.6
29.7
72
163
P72
ICPC
Schizophrenia
4.9
29.2
66
141
N05AN01
ATC
lithium; oral
4.3
29.1
78
191
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
5.7
28.9
54
97
N97.9
ICD-10 Finland
Female infertility, unspecified
2.7
28.4
171
692
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
4.8
28.2
65
141
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
+∞
28.2
27
*
N03AG01
ATC
valproic acid; systemic, rectal
3.0
27.3
131
470
F20.9
ICD-10 Finland
Schizophrenia, unspecified
4.7
27.0
64
142
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.2
26.7
114
382
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
26.1
25
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.8
25.9
620
4230
N06AB04
ATC
citalopram; systemic
2.0
25.4
346
1966
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.2
25.4
234
1147
N05BA06
ATC
lorazepam; systemic, sublingual
3.4
25.2
95
295
N91.4
ICD-10 Finland
Secondary oligomenorrhoea
9.0
25.1
31
35
N03AX09
ATC
lamotrigine; oral
2.7
24.7
137
531
N05AF05
ATC
zuclopenthixol; systemic
8.0
23.5
32
41
N05AF03
ATC
chlorprothixene; systemic
4.0
23.2
66
169
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.2
22.8
91
293
N04BC01
ATC
bromocriptine; oral
121.9
22.6
24
*
N05CD07
ATC
temazepam; oral
2.7
22.6
133
531
188
Kela drug reimbursment
Psychosis requiring demanding treatment
6.9
22.6
35
52
N06AX16
ATC
venlafaxine; oral
2.0
21.8
288
1611
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
5.1
21.7
46
93
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
4.1
21.5
59
147
E21.0
ICD-10 Finland
Primary hyperparathyroidism
50.8
21.2
25
5
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.0
20.9
277
1549
D352, E221,
ICD-10 Finland
+∞
19.8
19
*
N91.2
ICD-10 Finland
Amenorrhoea, unspecified
6.3
19.8
33
53
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.0
19.6
252
1393
F22.0
ICD-10 Finland
Delusional disorder
6.3
19.0
32
52
ZYC01
NOMESCO Finland
Remote contact by phone
2.5
18.8
127
541
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
18.8
354
2209
N05AA01
ATC
chlorpromazine; systemic, rectal
5.7
18.7
35
63
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
3.2
17.9
73
238
N06AB03
ATC
fluoxetine; oral
2.0
17.8
215
1159
E22.9
ICD-10 Finland
Hyperfunction of pituitary gland, unspecified
+∞
17.7
17
*
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
3.5
17.2
61
182
N05BA04
ATC
oxazepam; oral
1.7
17.0
398
2630
N05AE04
ATC
ziprasidone; systemic
6.0
17.0
30
51
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
5.2
17.0
35
69
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.2
16.9
154
747
2542
FHL
Transasal hypophysectomy
+∞
16.7
16
*
N06AX11
ATC
mirtazapine; oral
1.6
16.3
510
3624
F25.20
ICD-10 Finland
Schizoaffective syndrome, mixed type with only concomitant bipolar and schizophrenic symptoms
6.6
16.2
26
40
AA400
NOMESCO Finland
Electroconvulsive therapy
5.9
16.2
29
50
C07AA05
ATC
propranolol; systemic
1.7
16.0
356
2315
N05AD01
ATC
haloperidol; systemic
3.9
15.9
47
124
P29
ICPC
Psychological sympt/compl other
2.0
15.7
181
958
E23.6
ICD-10 Finland
Other disorders of pituitary gland
+∞
15.6
15
*
102
Kela drug reimbursment
Diabetes insipidus
161.7
15.5
16
*
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
5.3
15.4
31
60
N05AX13
ATC
paliperidone; systemic
6.8
15.3
24
36
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
3.7
15.3
48
132
F25.00
ICD-10 Finland
Schizoaffective syndrome, manic type with only simultaneous bipolar and schizophrenic symptoms
5.6
15.3
29
53
R53
ICD-10 Finland
Malaise and fatigue
1.6
15.0
401
2731
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
4.2
14.9
39
94
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
3.1
14.8
61
200
N05AF01
ATC
flupentixol; systemic
4.8
14.7
33
70
N03AE01
ATC
clonazepam; systemic
2.6
14.6
87
349
IEV99
NOMESCO Finland
Other psychiatric network intervention
6.4
14.6
24
38
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
2.8
14.4
72
264
IGY99
NOMESCO Finland
Other psychiatric treatment contact
3.1
14.4
61
204
N05BE01
ATC
buspirone; oral
3.2
14.3
56
178
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
3.4
13.9
51
156
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.9
13.8
199
1134
R42
ICD-10 Finland
Dizziness and giddiness
1.7
13.6
284
1806
E23.03
ICD-10 Finland
Lack of ACTH
141.3
13.5
14
*
E29.1
ICD-10 Finland
Testicular hypofunction
13.0
13.4
23
18
X05
ICPC
Menstruation absent/scanty
3.6
13.3
44
126
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
2.5
13.3
88
372
N06AG02
ATC
moclobemide; oral
2.8
13.3
65
236
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
2.8
13.3
65
236
ZY010
NOMESCO Finland
Hospital outpatient
2.2
13.2
111
520
F60.9
ICD-10 Finland
Personality disorder, unspecified
3.8
13.1
40
108
IER01
NOMESCO Finland
Psychoeducation, group
5.0
13.1
28
57
IBA02
NOMESCO Finland
Evaluation of need for psychiatric rehabilitation
5.5
13.1
25
46
IGY02
NOMESCO Finland
Psychiatric monitoring contact
2.5
13.0
82
338
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.1
13.0
134
681
X21
ICPC
Breast sympt/compl female other
2.9
12.9
60
212
N06AX21
ATC
duloxetine; oral
1.8
12.8
204
1200
ICB06, ,
NOMESCO Finland
5.0
12.7
27
55
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.7
12.6
239
1478
F61.0
ICD-10 Finland
Mixed personality disorders
3.5
12.5
43
126
IFB01
NOMESCO Finland
Electroconvulsive Therapy (ECT)
5.3
12.5
25
48
L17
ICPC
Foot/toe symptom/complaint
1.6
12.4
427
3066
P99
ICPC
Psychological disorders other
2.6
12.1
72
289
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
3.5
12.0
41
120
P98
ICPC
Psychosis NOS/other
5.7
12.0
22
39
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
11.9
311
2090
N05AC02
ATC
thioridazine; oral
3.6
11.9
39
111
F20.04
ICD-10 Finland
Paranoid schizophrenia with partial recurrence
5.4
11.8
23
43
F20.09
ICD-10 Finland
Paranoid schizophrenia UNS
5.4
11.8
23
43
ZXY49
NOMESCO Finland
Other health care provider
5.9
11.8
21
36
N05AL01
ATC
sulpiride; systemic
4.6
11.7
27
59
K59.0
ICD-10 Finland
Constipation
2.4
11.7
82
356
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.0
11.6
127
660
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
2.5
11.5
75
315
E22.88
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
11.5
11
*
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
120.9
11.4
12
*
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
11.4
465
3453
N05AE03
ATC
sertindole; oral
11.9
11.3
20
17
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
2.8
11.3
58
216
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
1.8
11.3
165
943
IER02
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, group
4.3
11.3
29
69
N05BA01
ATC
diazepam; systemic, rectal
1.8
11.3
168
966
H01CB02
ATC
octreotide; parenteral
35.3
11.3
14
*
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.5
11.3
484
3629
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
11.2
250
1612
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.1
11.1
102
495
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
3.6
11.1
36
102
F21
ICD-10 Finland
Schizotypal disorder
5.8
11.0
20
35
AA1AD
NOMESCO Finland
CT of head and brain
1.6
11.0
289
1941
N05CF01
ATC
zopiclone; oral
1.5
11.0
385
2762
R51.80
ICD-10 Finland
Headache
1.6
10.9
285
1912
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
10.8
174
1025
UJF32
NOMESCO Finland
Coloscopy
1.6
10.8
282
1892
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
4.5
10.8
26
59
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
3.3
10.6
40
125
N06AB06
ATC
sertraline; oral
1.7
10.6
208
1296
E23.2
ICD-10 Finland
Diabetes insipidus
110.8
10.4
11
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
10.4
331
2323
ZXC86
NOMESCO Finland
Use of endoscopic device
16.2
10.4
16
10
A02BC02
ATC
pantoprazole; systemic
1.4
10.2
897
7655
D35.31
ICD-10 Finland
Cyst in Rathke's pocket
23.5
10.2
14
6
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
10.1
600
4766
F25.21
ICD-10 Finland
Schizoaffective syndrome, mixed type with prolonged schizophrenic than bipolar symptoms
9.2
10.0
20
22
C03CA01
ATC
furosemide; systemic
1.7
10.0
204
1283
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.2
10.0
81
375
N06AB05
ATC
paroxetine; oral
2.0
9.7
101
515
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
9.6
344
2469
M79.6
ICD-10 Finland
Pain in limb
1.4
9.6
632
5098
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
3.3
9.6
35
107
G47.3
ICD-10 Finland
Sleep apnoea
1.6
9.6
273
1865
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.2
9.5
83
395
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.7
9.5
192
1203
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
2.3
9.5
68
298
25320
ICD-8 Finland
Diseases of pituitary gland, Chromophobe adenoma, pituitary
+∞
9.4
9
*
A55
ICPC
General and Unspecified, Local injection/infiltration
4.4
9.3
23
53
F23.90
ICD-10 Finland
Acute and transient psychosis, unspecified without acute stress factor
8.7
9.3
19
22
ZY000
NOMESCO Finland
Hospital inpatient
3.4
9.2
33
100
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.1
9.2
88
435
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
9.2
504
3930
SPAT1240
SPAT
Therapeutic discussion
1.7
9.1
197
1256
P01
ICPC
Feeling anxious/nervous/tense
1.5
9.1
282
1961
WVA30, ,
SPAT
2.1
9.1
83
403
X78
ICD-10 Finland
Intentional self-harm by sharp object
4.6
9.1
21
46
F23.8
ICD-10 Finland
Other acute and transient psychotic disorders
8.4
9.1
19
23
ZXE01
NOMESCO Finland
Procedure duration 0 to 9 minutes
3.3
9.1
34
106
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
1.8
9.0
139
809
E28.3
ICD-10 Finland
Primary ovarian failure
18.7
8.9
13
7
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
8.9
315
2252
IEY01
NOMESCO Finland
Psychoeducation, individual
4.0
8.9
25
64
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
2.7
8.9
45
167
Z2446
NOMESCO Finland
Social worker
2.0
8.9
97
504
121
Kela drug reimbursment
Severe hypofunction of sexual glands
3.5
8.8
30
88
N03AX16
ATC
[U] pregabalin
1.5
8.7
273
1900
L28
ICPC
Limited function/disability (L)
1.7
8.7
181
1143
F28
ICD-10 Finland
Other nonorganic psychotic disorders
9.0
8.5
17
19
IAB01
NOMESCO Finland
Psychiatric pharmacotherapy consultation
3.8
8.5
25
66
R11
ICD-10 Finland
Nausea and vomiting
1.8
8.5
132
769
D12
ICPC
Constipation
2.6
8.5
48
189
Z3231
NOMESCO Finland
Registered nurse
1.5
8.4
329
2397
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
90.6
8.4
9
*
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
90.6
8.4
9
*
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
90.6
8.4
9
*
N06AA04
ATC
clomipramine; systemic
3.5
8.4
28
81
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.7
8.3
172
1084
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
8.3
558
4489
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.1
8.2
76
371
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
2.8
8.2
39
140
F31.20
ICD-10 Finland
Bipolar disorder, manic episode with mood-congruent psychotic symptoms
4.2
8.2
21
50
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.8
8.2
136
808
T99
ICPC
Endocr/metab/nutrit disease other
3.5
8.1
27
78
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
2.2
8.1
70
333
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.8
8.1
124
720
R06.0
ICD-10 Finland
Dyspnoea
1.5
8.0
312
2269
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.8
8.0
127
744
P28
ICPC
Limited function/disability (P)
3.9
8.0
23
60
F31
ICD-10 Finland
Bipolar affective disorder
3.2
8.0
31
99
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.2
8.0
65
302
IEY08
NOMESCO Finland
Psychiatric coaching, domestic and community skills
7.3
8.0
18
25
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.0
7.9
90
474
3018D
ICD-9 Finland
Personality disorders, Other personality disorders[EPÄVAKAA PERSOONALLISUUS]
7.8
7.9
17
22
E66.8
ICD-10 Finland
Other obesity
1.9
7.8
106
592
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.8
7.8
111
629
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
1.9
7.8
99
541
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
7.7
125
737
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
3.2
7.7
29
91
SPAT1263
SPAT
Sampling
1.4
7.6
554
4497
Z3229
NOMESCO Finland
Other healthcare associate professional
1.9
7.6
91
488
A06AD11
ATC
lactulose; oral
1.8
7.6
123
725
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
2.1
7.6
66
315
N03AX12
ATC
[U] gabapentin; oral
1.6
7.6
194
1290
F20.3
ICD-10 Finland
Undifferentiated schizophrenia
6.2
7.5
19
31
R41.0
ICD-10 Finland
Disorientation, unspecified
3.3
7.5
28
87
A02BC05
ATC
esomeprazole; systemic
1.4
7.5
508
4073
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
2.0
7.5
74
371
F44.9
ICD-10 Finland
Dissociative [conversion] disorder, unspecified
4.3
7.5
19
45
K59.09
ICD-10 Finland
Constipation, unspecified
2.0
7.4
77
393
IGV01
NOMESCO Finland
Psychiatric network contact
3.3
7.4
27
83
H53.4
ICD-10 Finland
Visual field defects
3.0
7.4
31
104
R55
ICD-10 Finland
Syncope and collapse
1.8
7.3
108
620
2370A
ICD-9 Finland
Neoplasm of uncertain behaviour of endocrine glands and nervous system, Pituitary gland and craniopharyngeal duct
+∞
7.3
7
*
E22.2
ICD-10 Finland
Syndrome of inappropriate secretion of antidiuretic hormone
+∞
7.3
7
*
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
+∞
7.3
7
*
E23
ICD-10 Finland
Hypofunction and other disorders of pituitary gland
+∞
7.3
7
*
106
Kela drug reimbursment
Hypoparathyroidism
+∞
7.3
7
*
G44.0
ICD-10 Finland
Cluster headache syndrome
3.3
7.3
26
79
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
2.9
7.2
33
116
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.7
7.2
122
728
N05AX15
ATC
cariprazine; oral
5.8
7.2
19
33
IBZ02
NOMESCO Finland
Somatic assessment of psychiatric patient
4.3
7.2
18
42
F25.01
ICD-10 Finland
Schizoaffective syndrome, manic type with prolonged schizophrenic than bipolar symptoms
7.3
7.2
16
22
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
7.1
304
2246
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.6
7.1
155
990
O92.6
ICD-10 Finland
Galactorrhoea
8.8
7.1
14
16
ZXY59
NOMESCO Finland
2-person team, nurse-other special worker
10.1
7.0
13
13
E0000UV, ,
ATC
1.4
7.0
585
4834
G03DC02
ATC
norethisterone; oral
1.7
7.0
130
797
F20.39
ICD-10 Finland
Undifferentiated schizophrenia UNS
4.4
7.0
17
39
Z01.2
ICD-10 Finland
Dental examination
1.3
6.9
709
6037
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
6.9
490
3947
F31.8
ICD-10 Finland
Other bipolar affective disorders
2.4
6.9
44
184
N06AA10
ATC
nortriptyline; systemic
2.8
6.9
34
125
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.0
6.8
75
391
F25.1
ICD-10 Finland
Schizoaffective disorder, depressive type
8.3
6.8
14
17
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
2.6
6.8
37
143
XF404
NOMESCO Finland
Ambulatory ECG
1.9
6.8
81
434
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
11.0
6.8
12
11
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
2.4
6.8
46
198
D01
ICPC
Abdominal pain/cramps general
1.5
6.8
199
1364
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.6
6.7
162
1060
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
1.8
6.7
90
501
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.5
6.7
208
1442
R04
ICPC
Breathing problem other
2.2
6.7
55
257
N06AX03
ATC
mianserin; oral
2.1
6.7
58
277
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
2.8
6.7
32
116
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
2.7
6.6
33
122
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.4
6.6
326
2470
2968A
ICD-9 Finland
Affective psychoses, Manic-depressive psychosis, other and unspecified
5.5
6.6
18
33
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.8
6.6
103
601
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
6.6
314
2364
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
4.2
6.6
17
41
U02
ICPC
Urinary frequency/urgency
1.5
6.5
200
1384
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
1.9
6.5
78
420
IFA99, ,
SPAT
6.2
6.5
16
26
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
2.4
6.4
44
190
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.5
6.4
213
1496
SPAT1243
SPAT
Psychiatric/psychological examination
2.2
6.4
54
255
WZC00
NOMESCO Finland
Treatment plan or consultation
1.3
6.4
505
4124
N05AL05
ATC
amisulpride; oral
14.4
6.4
10
7
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.4
6.4
280
2076
F61
ICD-10 Finland
Mixed and other personality disorders
8.2
6.3
13
16
A06AC51
ATC
ispaghula, combinations; oral
2.1
6.3
60
297
R02
ICPC
Shortness of breath/dyspnoea
1.6
6.3
151
987
-50
ICPC
Medication/prescr/renewal
2.3
6.3
47
211
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.9
6.3
79
431
IHZ29, ,
SPAT
11.1
6.3
11
10
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
6.3
678
5789
L12
ICPC
Hand/finger symptom/complaint
1.4
6.3
253
1847
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.6
6.3
142
916
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
18.1
6.3
9
5
S18
ICPC
Laceration/cut
1.3
6.3
552
4579
E23.06
ICD-10 Finland
Empty sella
+∞
6.3
6
*
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
+∞
6.3
6
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.4
6.2
417
3318
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
2.8
6.2
30
109
H01CB03
ATC
lanreotide; parenteral
26.8
6.2
8
*
TPH07
NOMESCO Finland
Cathetrisation of artery
1.8
6.2
94
544
IGY02, ,
SPAT
2.7
6.2
32
121
F50.9
ICD-10 Finland
Eating disorder, unspecified
2.9
6.2
27
93
G03DA02
ATC
medroxyprogesterone; systemic
1.8
6.2
93
538
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.5
6.1
194
1349
SPAT1296
SPAT
Other function in accordance with occupational therapy nomenclature
5.8
6.1
16
28
P73
ICPC
Affective psychosis
5.8
6.1
16
28
E66.01
ICD-10 Finland
Obesity due to excess calories
1.5
6.1
167
1125
ZXY82
NOMESCO Finland
Nurse in multidisciplinary team
4.1
6.1
16
39
N62
ICD-10 Finland
Hypertrophy of breast
1.9
6.1
74
400
F33.3
ICD-10 Finland
Recurrent depressive disorder, current episode severe with psychotic symptoms
8.6
6.1
12
14
SPAT1310
SPAT
Counselling related to known health issue
1.4
6.0
397
3148
A04AA01
ATC
ondansetron; systemic, rectal
1.7
6.0
98
579
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
739
832
16.97
307.65
6.3
1.4
712.34
290.27
mu/l
11.58
713
750
621
1242
7.96
307.65
3.9
1.8
371.00
382.72
nmol/l
0.85
606
1163
381
469
10.64
301.79
1.8
1.2
7.64
10.95
u/l
4.02
307
378
274
243
13.65
271.05
5.2
1.3
764.54
374.98
mu/l
3.87
257
195
148
119
13.73
153.48
1.5
1.2
25.01
23.76
ng/l
0.16
148
119
285
603
5.63
131.55
5.4
1.9
9.05
11.58
nmol/l
5.17
269
562
214
404
6.04
110.89
1.6
1.3
0.30
0.48
nmol/l
2.53
167
334
131
177
8.03
92.79
3.3
1.5
153.53
196.83
pmol/l
2.46
126
163
373
1402
3.23
75.56
1.7
1.3
16.16
26.00
iu/l
8.85
309
1214
134
350
4.11
46.09
1.9
1.3
13.49
24.82
u/l
5.64
121
290
1317
10745
3.32
43.67
7.5
4.6
14.45
14.33
pmol/l
1.03
1274
10157
60
86
7.23
40.04
1.4
1.2
5.69
5.37
umol/l
0.25
55
78
714
4672
2.03
38.01
7.7
5.5
1.22
1.21
mmol/l
1.66
678
4356
782
5309
2.02
37.28
8.7
6.0
1.22
1.21
mmol/l
1.51
685
4637
229
979
2.59
34.32
3.0
3.7
4.40
4.62
pmol/l
3.22
213
889
45
60
7.71
31.95
1.4
1.4
1.76
1.71
nmol/l
0.03
38
42
1376
12223
3.21
25.66
8.4
5.4
1.70
1.78
mu/l
1.96
1338
11683
55
118
4.80
24.20
9.9
14.3
0.60
0.63
mmol/l
0.28
49
107
1120
9378
1.84
20.82
4.7
4.1
10.82
9.75
mm/h
2.09
1069
8903
654
4800
1.66
19.21
5.2
4.5
36.49
36.94
g/l
1.32
613
4555
1101
9253
1.77
19.19
8.8
7.4
75.18
74.49
u/l
0.25
1066
8836
559
3945
1.68
19.08
3.4
3.2
2.34
2.35
mmol/l
0.12
515
3653
1377
12527
2.77
18.96
20.0
12.5
139.74
139.61
mmol/l
1.54
1357
12284
46
105
4.49
18.79
2.2
1.4
288.13
281.12
mosm/kgh2o
1.28
40
80
1376
12555
2.69
18.04
20.1
12.6
3.92
3.92
mmol/l
0.08
1355
12277
53
141
3.86
17.71
2.3
1.9
4.02
4.84
mmol/24h
1.40
48
131
143
663
2.28
17.49
4.7
3.2
91.97
70.92
ng/l
0.85
125
603
850
6809
1.59
16.44
6.1
4.4
6.17
6.37
mmol/l
3.00
799
6290
252
1475
1.86
16.25
1.9
1.6
1175.36
1167.18
nmol/l
0.04
207
1151
213
1210
1.89
15.01
7.3
5.7
1.02
1.04
mmol/l
0.63
198
1125
515
3758
1.57
14.31
3.2
2.5
52.79
58.25
u/l
1.58
480
3513
427
2982
1.61
14.30
1.8
1.6
19.73
20.39
nmol/l
0.41
374
2643
737
5842
1.53
13.96
3.1
2.4
73.61
74.60
nmol/l
0.49
695
5473
212
1243
1.83
13.45
2.6
2.2
7121.64
6369.67
u/l
0.12
65
508
268
1701
1.71
12.89
2.8
2.2
2.48
2.43
g/l
0.69
239
1588
1270
11498
1.81
12.88
6.0
4.9
37.44
37.58
mmol/mol
0.26
1221
11016
889
7414
1.51
12.69
14.4
9.3
4.03
3.96
e9/l
0.42
794
6504
24
45
5.41
12.32
1.1
1.2
67.67
66.96
nmol/24h
0.02
24
45
622
4849
1.49
12.19
2.2
1.9
100.52
98.04
pmol/l
0.64
344
2644
1421
13475
3.09
11.75
21.4
14.3
72.50
69.11
umol/l
2.99
1408
13346
1297
11888
1.82
11.65
5.4
4.2
5.67
5.68
mmol/l
0.11
1243
11239
142
773
1.93
11.30
4.1
2.6
1.23
1.23
mmol/l
0.61
126
662
319
2191
1.58
11.06
1.6
1.6
28364102.09
49534584.49
pmol/l
0.29
275
1932
435
3217
1.50
10.72
2.7
2.2
2.56
2.61
mg/l
0.21
371
2843
438
3269
1.49
10.23
3.5
2.1
166.72
163.05
u/l
0.05
419
3130
298
2061
1.56
9.92
2.6
2.5
2.43
2.42
mmol/l
1.55
260
1845
1309
12135
1.77
9.89
15.9
10.7
89.66
90.85
ml/min/173m2
1.40
1227
11037
643
5206
1.42
9.58
1.9
1.8
1.45
1.34
mmol/l
2.38
545
4570
273
1868
1.57
9.49
3.0
2.2
13.68
14.57
umol/l
1.22
252
1752
878
7542
1.41
9.14
3.8
3.2
86.55
80.10
ug/l
0.26
829
7221
251
1702
1.57
9.05
3.8
3.5
0.82
0.82
mmol/l
0.14
237
1622
229
1522
1.60
8.99
3.0
2.3
21.89
24.13
%
1.82
205
1426
482
3750
1.43
8.79
1.4
1.3
1.56
1.54
u/ml
0.01
135
1096
460
3575
1.42
8.35
3.7
3.3
8.03
7.94
mmol/l
0.14
398
3137
120
685
1.82
8.25
2.8
2.8
66.62
67.49
g/l
0.69
112
650
562
4546
1.38
7.99
3.7
3.2
27.35
28.75
u/l
0.75
534
4338
314
2290
1.47
7.97
3.7
3.0
656.44
740.93
ng/l
0.33
261
1888
1356
12835
1.80
7.70
17.7
12.2
18.72
20.41
mg/l
1.28
1114
10365
19
44
4.36
7.69
2.6
2.2
16.09
16.67
umol/l
0.08
19
44
1066
9599
1.41
7.62
4.1
3.1
41.32
37.24
u/l
0.91
1028
9266
460
3624
1.39
7.57
3.9
2.9
58.65
97.32
e6/l
0.52
359
2683
327
2443
1.44
7.24
3.3
2.4
6.99
7.98
e6/l
0.64
298
2208
402
3122
1.40
7.13
3.9
2.8
0.25
0.33
e6/l
0.59
301
2203
717
6111
1.34
6.98
6.8
6.0
9.87
10.26
umol/l
0.53
681
5836
14
17
8.30
6.83
1.7
1.1
5.85
3.84
nmol/l
1.70
14
17
137
858
1.66
6.80
9.3
8.1
1.10
1.28
mmol/l
2.67
137
842
175
1169
1.56
6.67
2.2
1.7
—
—
—
0
0
259
1898
1.44
6.30
1.9
1.7
1.40
1.39
%
0.16
239
1709
87
495
1.81
6.09
3.1
3.2
1.34
1.65
mmol/l
0.40
64
366
83
466
1.83
6.07
1.7
2.3
1.93
4.36
iu/l
6.60
37
212
22
68
3.27
6.01
4.3
3.8
109.08
156.68
umol/l
0.48
12
38
404
3217
1.35
5.98
1.5
1.5
2.18
2.20
g/l
0.10
254
2154
280
2105
1.41
5.88
1.9
2.6
83.94
100.71
ug/g
0.86
214
1687
167
1137
1.53
5.84
2.3
1.8
—
—
—
0
0
1446
14137
3.56
5.63
30.4
18.9
266.59
263.65
e9/l
1.01
1431
13946
227
1656
1.44
5.63
2.4
1.8
—
—
—
0
0
1261
11876
1.46
5.62
4.3
3.7
1.31
1.22
mmol/l
4.28
1198
11295
1446
14140
3.54
5.56
30.2
18.8
90.03
90.39
fl
2.77
1439
14050
10
10
10.06
5.53
1.4
1.5
—
—
—
0
0
1446
14142
3.52
5.52
30.8
19.2
40.40
40.36
%
0.13
1439
14046
1446
14143
3.52
5.50
30.2
18.9
4.51
4.51
e12/l
0.02
1428
13925
191
1355
1.47
5.48
1.3
1.3
119.28
148.69
u/ml
0.52
72
531
1446
14145
3.50
5.46
30.3
18.9
6.66
6.71
e9/l
0.34
1428
13917
145
972
1.55
5.45
9.4
9.4
1.38
0.79
mmol/l
1.27
121
786
135
892
1.57
5.41
5.2
3.5
2.05
1.77
mmol/l
0.51
124
779
930
8384
1.30
5.39
5.8
4.0
38.91
2067.82
e6/l
1.65
11
102
1446
14151
3.45
5.33
30.5
19.0
134.22
134.92
g/l
1.36
1440
14059
1395
13469
1.81
5.25
13.2
10.3
26.09
25.06
u/l
1.52
1368
13191
468
3880
1.30
5.09
4.8
2.9
27.79
49.09
ng/l
0.50
255
2023
145
987
1.52
5.09
9.4
9.3
5.23
5.07
kpa
1.43
138
947
145
987
1.52
5.09
9.4
9.3
12.73
13.13
kpa
0.37
137
947
785
6956
1.28
5.04
4.3
3.4
0.01
0.00
estimate
0.66
173
1401
250
1905
1.38
4.80
3.2
2.5
1.07
0.92
e6/l
0.32
138
931
147
1021
1.49
4.69
3.2
2.7
10.48
10.55
g/l
0.08
129
952
59
324
1.86
4.69
3.6
3.9
1.48
1.25
mg/l
1.60
52
299
232
1754
1.38
4.67
3.3
2.6
5.13
3.77
e6/l
0.73
118
791
33
146
2.29
4.66
1.3
1.2
0.55
12.87
nmol/l
0.50
33
138
86
530
1.66
4.60
2.1
1.6
—
—
—
0
0
368
2991
1.31
4.56
4.5
3.6
97.57
95.78
%
0.74
363
2924
141
980
1.49
4.49
3.5
2.6
—
—
—
0
0
786
7024
1.26
4.47
4.4
3.4
0.00
5.68
estimate
1.58
176
1413
56
308
1.85
4.45
1.1
1.5
260.32
13.85
e6/l
0.48
38
231
38
182
2.12
4.45
3.5
2.2
7.04
6.53
pmol/l
0.28
38
182
251
1938
1.36
4.42
3.8
3.2
621.98
356.17
ng/l
0.27
156
1134
789
7070
1.25
4.32
4.4
3.5
0.00
0.23
estimate
0.52
169
1362
138
967
1.47
4.23
2.2
2.4
0.22
0.22
g/l
0.11
125
916
1320
12655
1.45
4.23
5.7
4.7
2.85
2.84
mmol/l
0.10
1267
12097
92
591
1.59
4.20
1.6
1.8
—
—
—
0
0
56
314
1.81
4.20
1.2
1.5
1326.95
1130.94
e6/l
0.05
42
246
82
512
1.64
4.20
12.2
11.6
24.61
24.29
mmol/l
0.49
82
505
1312
12569
1.44
4.17
5.2
4.3
4.73
4.78
mmol/l
1.18
1260
12064
171
1261
1.40
3.99
4.6
4.0
30.99
32.07
%
0.69
139
928
1307
12529
1.41
3.98
5.1
4.3
1.44
1.51
mmol/l
7.91
1253
11971
18
64
2.84
3.96
2.0
1.5
—
—
—
0
0
15
48
3.15
3.93
1.3
2.2
—
—
—
0
0
28
125
2.26
3.91
1.2
1.2
0.19
0.32
nmol/l
0.39
20
87
121
847
1.47
3.75
1.7
1.4
—
—
—
0
0
26
116
2.26
3.65
1.3
1.8
—
—
—
0
0
367
3059
1.27
3.65
4.2
4.1
6.86
8.93
mg/mmol
0.49
219
1937
357
2971
1.27
3.59
2.4
2.4
318.57
312.17
umol/l
0.50
311
2664
41
220
1.89
3.57
4.2
3.7
31.01
66.13
mg/l
0.73
33
196
109
757
1.48
3.53
1.7
1.7
—
—
—
0
0
50
287
1.77
3.52
2.3
3.0
1.56
2.17
index
0.42
25
152
139
1012
1.41
3.50
2.4
2.4
21.11
19.72
au/ml
0.04
12
135
22
94
2.36
3.42
9.9
4.9
8.85
7.23
mmol/l
0.39
14
77
36
188
1.94
3.40
1.6
1.5
—
—
—
0
0
80
525
1.55
3.38
2.8
2.6
1.02
1.02
ratio
0.06
69
469
40
220
1.84
3.25
4.3
3.7
24.88
27.96
mg/l
0.36
33
195
47
273
1.75
3.20
1.8
1.5
—
—
—
0
0
180
1396
1.33
3.08
2.9
2.5
7.27
6.51
umol/l
0.23
142
1202
83
563
1.50
3.05
5.4
3.4
24.64
24.23
mmol/l
0.69
83
558
82
557
1.50
3.00
1.6
1.4
—
—
—
0
0
11
31
3.57
2.99
1.1
1.1
113.82
92.35
%
2.50
11
31
46
749
0.60
2.96
1.2
1.1
1.56
1.58
g/l
0.19
46
749
56
350
1.62
2.94
1.4
1.4
236.74
303.25
ug/g
1.61
30
186
82
560
1.49
2.93
3.0
2.9
114.49
125.15
ng/l
0.12
71
497
47
759
0.61
2.92
1.2
1.1
0.82
0.88
g/l
1.13
47
759
10
27
3.72
2.88
1.9
1.9
46.20
55.85
ug/l
—
10
27
51
314
1.65
2.85
3.4
3.7
24.76
24.83
mmol/l
0.06
45
296
32
173
1.87
2.78
2.8
1.7
—
—
—
0
0
42
248
1.71
2.74
1.5
1.3
4.22
4.18
u/ml
0.01
18
112
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
37
211
1.77
2.72
3.1
4.4
0.37
0.39
iu/ml
0.18
23
106
189
1504
1.29
2.70
5.6
4.7
1.36
2.19
ug/l
2.32
177
1370
56
359
1.58
2.68
1.9
2.3
10.03
10.73
mg/l
0.35
50
344
17
73
2.34
2.65
1.6
1.7
—
—
—
0
0
34
192
1.79
2.60
4.8
3.5
15.91
2.09
ratio
0.64
18
115
124
938
1.35
2.54
1.3
1.3
113.00
33.32
au/ml
—
6
62
123
933
1.35
2.48
1.1
1.1
—
—
—
0
0
327
2799
1.22
2.48
2.5
2.2
—
—
—
0
0
32
182
1.78
2.41
1.3
1.2
—
—
—
0
0
461
4087
1.19
2.38
3.5
2.7
0.01
0.08
estimate
0.85
152
1174
42
259
1.64
2.37
9.1
6.1
4987.17
335.44
iu/ml
—
6
32
79
561
1.43
2.36
1.8
2.2
40.87
39.86
u/l
0.20
70
527
13
52
2.51
2.36
3.8
1.9
—
—
—
0
0
13
52
2.51
2.36
3.8
1.9
—
—
—
0
0
13
52
2.51
2.36
3.8
1.9
—
—
—
0
0
13
52
2.51
2.36
3.8
1.9
—
—
—
0
0
423
3726
1.19
2.35
4.4
3.6
0.00
0.00
estimate
1.47
174
1352
19
91
2.10
2.33
3.0
2.7
504.64
467.39
e6/l
0.16
14
77
91
665
1.39
2.32
1.9
1.6
0.15
0.30
mg/l
4.23
38
291
131
1014
1.32
2.31
4.9
4.7
238.46
247.21
u/l
0.21
123
964
358
3110
1.20
2.31
1.9
1.8
0.87
0.91
mg/l
0.12
282
2360
52
341
1.54
2.29
1.7
2.0
1.32
1.39
g/l
0.22
43
300
355
3086
1.20
2.28
2.6
2.3
—
—
—
0
0
6
13
4.63
2.27
1.3
1.6
39.73
47.45
nmol/l
—
6
13
89
653
1.39
2.23
7.8
2.2
5.29
6.62
ug/l
0.29
76
590
5
9
5.57
2.21
1.2
1.9
234.00
435.00
ug/l
—
5
9
1177
11309
1.21
2.21
23.9
14.8
13.44
13.36
%
1.52
1167
11171
318
2750
1.20
2.15
1.4
1.3
6.42
9.50
u/ml
0.54
121
1157
63
440
1.45
2.09
2.0
2.3
96.89
94.69
%
0.39
63
426
23
124
1.87
2.07
1.1
1.1
—
—
—
0
0
40
256
1.58
1.99
1.7
1.2
—
—
—
0
0
145
1164
1.27
1.98
3.3
2.4
30.50
40.80
u/l
1.41
125
973
32
194
1.66
1.97
1.1
1.3
—
—
—
0
0
32
194
1.66
1.97
1.1
1.3
—
—
—
0
0
23
127
1.82
1.94
1.9
1.5
—
—
—
0
0
5
11
4.56
1.94
2.2
1.6
—
—
—
0
0
43
284
1.53
1.88
2.4
1.6
—
—
—
0
0
23
129
1.80
1.86
1.9
1.5
—
—
—
0
0
39
253
1.56
1.85
1.2
1.1
—
—
—
0
0
20
108
1.86
1.82
1.5
1.5
—
—
—
0
0
26
153
1.71
1.80
1.8
1.4
—
—
—
0
0
11
47
2.35
1.78
1.4
1.4
107.00
162.09
pmol/l
1.06
11
47
26
154
1.70
1.76
1.8
1.4
—
—
—
0
0
14
67
2.10
1.76
1.1
1.1
—
—
—
0
0
588
5414
1.14
1.76
4.2
3.2
0.02
0.02
estimate
0.09
149
1169
18
95
1.91
1.75
1.4
2.0
31.72
32.12
pg
0.10
18
95
42
282
1.50
1.73
1.5
1.4
137.09
156.29
au/ml
0.49
12
78
18
96
1.89
1.71
3.3
1.7
—
—
—
0
0
18
96
1.89
1.71
3.3
1.7
—
—
—
0
0
18
96
1.89
1.71
3.3
1.7
—
—
—
0
0
81
1053
0.76
1.68
1.4
1.4
—
—
—
0
0
29
181
1.61
1.64
1.7
1.6
—
—
—
0
0
108
860
1.28
1.61
2.9
2.2
0.41
0.24
e6/l
0.54
103
812
40
271
1.49
1.60
2.9
2.7
—
—
—
0
0
145
1197
1.23
1.59
4.3
4.0
24.51
21.22
%
1.20
53
491
10
43
2.33
1.59
2.7
1.7
97.50
88.58
ng/l
—
10
43
137
1125
1.24
1.58
6.7
5.2
—
—
—
0
0
24
144
1.68
1.58
2.0
2.0
—
—
—
0
0
33
215
1.55
1.57
2.2
2.0
132.96
133.14
g/l
0.01
26
173
25
152
1.66
1.57
1.8
1.4
—
—
—
0
0
44
306
1.45
1.55
1.5
1.4
—
20.40
—
0
5
7
27
2.60
1.51
1.3
1.2
—
—
—
0
0
16
86
1.87
1.50
1.6
3.3
486.00
1281.74
mg
2.22
16
86
29
439
0.65
1.48
1.2
1.3
—
—
—
0
0
133
1599
0.81
1.47
1.5
1.6
953.38
1007.32
mu/l
0.28
119
1338
11
52
2.12
1.44
2.5
1.5
—
—
—
0
0
40
278
1.45
1.43
1.6
1.4
—
—
—
0
0
342
3078
1.15
1.40
4.3
3.5
1.02
1.51
kg/l
0.50
228
2036
0
39
0.00
1.34
0.0
2.3
—
1.78
—
0
20
9
42
2.15
1.33
4.8
3.3
1.67
1.95
ratio
—
9
36
12
61
1.98
1.33
1.2
1.5
134.33
149.62
mmol/24h
0.51
12
61
23
144
1.61
1.32
1.9
1.4
—
—
—
0
0
6
24
2.51
1.30
1.2
1.5
—
—
—
0
0
23
145
1.60
1.29
1.9
1.4
—
—
—
0
0
23
145
1.60
1.29
1.9
1.4
—
—
—
0
0
11
55
2.01
1.27
2.5
1.5
—
—
—
0
0
60
458
1.32
1.27
1.0
1.1
7.13
5.56
eliau/ml
—
6
73
11
203
0.54
1.25
1.3
1.5
—
—
—
0
0
178
2045
0.85
1.22
1.7
1.8
3.47
3.36
ratio
0.58
130
1519
26
172
1.52
1.21
1.5
1.4
—
—
—
0
0
73
579
1.27
1.18
1.4
1.3
—
—
—
0
0
8
38
2.11
1.18
5.3
2.2
—
—
—
0
0
8
38
2.11
1.18
5.3
2.2
—
—
—
0
0
8
38
2.11
1.18
5.3
2.2
—
—
—
0
0
12
64
1.88
1.18
1.3
1.4
2.23
2.02
umol/l
0.42
12
56
49
368
1.34
1.17
1.7
1.3
—
—
—
0
0
97
797
1.23
1.17
1.4
1.3
252.69
229.88
miu/ml
0.20
42
421
109
910
1.21
1.13
3.4
2.8
0.64
0.70
ug/l
0.49
72
526
11
58
1.90
1.12
2.5
1.5
—
—
—
0
0
46
345
1.34
1.12
1.4
1.3
—
38.25
—
0
11
77
620
1.26
1.11
1.3
1.3
0.20
0.99
u/ml
—
6
43
41
302
1.37
1.11
2.7
1.6
—
—
—
0
0
14
81
1.74
1.09
1.6
2.2
—
—
—
0
0
18
112
1.61
1.09
1.9
1.6
52.18
54.91
%
0.09
11
68
8
41
1.96
1.09
2.3
2.7
1.13
1.48
%
—
8
41
326
2978
1.12
1.06
1.5
1.3
25.20
24.55
iu/ml
0.05
85
865
132
1131
1.18
1.05
1.4
1.3
758.25
218.84
u/ml
0.39
118
1056
331
3036
1.12
1.00
2.6
2.1
—
—
—
0
0
7
35
2.00
1.00
2.3
2.2
41.80
42.07
g/l
—
7
35
17
107
1.60
0.99
1.5
1.9
11.00
21.48
mg/l
—
5
52
7
36
1.95
0.97
1.4
1.1
—
—
—
0
0
15
93
1.62
0.94
1.1
1.5
10.23
10.49
umol/l
0.07
15
84
23
158
1.46
0.94
1.2
1.1
—
—
—
0
0
17
109
1.57
0.93
1.2
1.2
—
88.20
—
0
5
6
27
2.23
0.93
1.0
1.1
—
—
—
0
0
6
28
2.15
0.91
3.3
4.4
—
—
—
0
0
12
71
1.70
0.89
1.6
1.2
—
—
—
0
0
76
911
0.83
0.88
1.4
1.5
61.18
59.90
ug/l
0.08
70
762
14
87
1.62
0.87
1.1
1.4
—
—
—
0
0
34
256
1.34
0.85
1.6
1.2
2.71
4.57
u/ml
0.67
14
92
6
31
1.94
0.84
1.3
1.2
—
—
—
0
0
6
31
1.94
0.84
1.2
1.1
—
—
—
0
0
19
272
0.69
0.82
1.4
2.0
—
—
—
0
0
47
587
0.79
0.82
1.4
1.5
61.51
60.88
ug/l
0.04
47
587
71
847
0.83
0.80
1.4
1.5
0.89
0.95
ratio
1.10
47
516
71
847
0.83
0.80
1.4
1.5
1.15
1.21
ratio
0.24
47
518
71
846
0.83
0.79
1.4
1.5
1.03
1.15
ratio
0.66
47
515
17
114
1.50
0.79
1.2
1.2
0.50
0.63
ratio
—
10
63
6
33
1.82
0.79
1.0
1.1
—
—
—
0
0
16
106
1.52
0.79
1.0
1.1
127.69
111.18
pmol/l
0.76
16
106
14
90
1.56
0.78
1.3
1.6
0.55
0.48
e9/l
0.30
14
90
41
323
1.28
0.76
1.4
1.3
210.38
241.05
u/ml
0.38
28
209
35
270
1.30
0.76
5.0
4.1
1.15
1.41
mmol/l
1.48
35
264
13
83
1.57
0.75
3.9
2.4
—
—
—
0
0
20
141
1.42
0.74
1.3
1.2
0.07
0.56
u/ml
0.89
14
65
5
24
2.09
0.74
2.6
2.7
0.54
0.62
mmol/l
—
5
24
14
92
1.53
0.72
1.4
1.5
5.53
5.59
mmol/l
0.06
14
92
9
57
1.58
0.71
1.0
1.1
—
—
—
0
0
71
835
0.84
0.71
1.4
1.5
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
11
69
1.60
0.68
1.2
1.1
—
—
—
0
0
50
411
1.22
0.67
2.9
2.0
—
—
—
0
0
26
197
1.33
0.66
2.7
2.6
48.57
137.39
ug/min
1.33
14
130
16
111
1.45
0.66
1.6
1.3
—
—
—
0
0
1060
10373
1.08
0.65
3.9
3.7
—
—
—
0
0
23
172
1.34
0.64
1.9
1.4
—
—
—
0
0
105
927
1.14
0.63
2.6
2.3
79.48
76.97
ml/min/173m2
0.32
42
358
34
271
1.26
0.61
1.7
1.4
—
—
—
0
0
8
52
1.54
0.59
1.0
1.2
—
—
—
0
0
6
35
1.72
0.57
1.5
1.0
—
—
—
0
0
66
764
0.86
0.57
1.5
1.6
—
—
—
0
0
55
466
1.19
0.57
1.4
1.3
16.47
11.37
u/ml
—
7
76
30
238
1.27
0.57
1.8
1.4
—
—
—
0
0
6
36
1.67
0.56
1.5
1.1
—
—
—
0
0
57
486
1.18
0.56
1.7
1.5
0.21
0.17
iu/ml
—
5
73
34
275
1.24
0.55
1.1
1.1
—
—
—
0
0
6
37
1.62
0.55
1.7
1.1
—
—
—
0
0
13
90
1.45
0.55
1.4
1.3
76.77
70.48
umol/l
0.18
13
90
9
62
1.45
0.53
2.3
3.8
1.00
0.76
index
—
9
62
54
628
0.85
0.51
1.7
2.0
—
—
—
0
0
9
65
1.39
0.50
1.1
1.2
—
—
—
0
0
6
41
1.47
0.50
1.0
1.8
—
—
—
0
0
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
6
41
1.47
0.50
1.0
1.1
—
66.00
—
0
11
6
41
1.47
0.50
1.0
1.8
—
—
—
0
0
44
371
1.19
0.50
2.3
1.8
—
—
—
0
0
35
422
0.83
0.50
1.4
1.4
51.06
116.55
pmol/l
1.52
35
414
145
1579
0.91
0.50
1.5
1.6
3.47
3.45
mmol/l
0.06
103
1060
7
46
1.52
0.48
3.1
1.4
—
—
—
0
0
7
46
1.52
0.48
1.0
1.0
—
—
—
0
0
7
48
1.46
0.46
3.1
1.4
—
—
—
0
0
5
82
0.61
0.46
1.2
1.7
—
—
—
0
0
8
56
1.43
0.42
1.4
1.4
—
—
—
0
0
402
3863
1.06
0.41
1.9
1.7
—
—
—
0
0
8
60
1.34
0.40
1.3
1.2
165.00
413.40
u/l
—
8
53
0
18
0.00
0.40
0.0
2.3
—
0.94
—
0
18
0
18
0.00
0.40
0.0
1.9
—
—
—
0
0
5
35
1.43
0.39
1.6
1.1
—
—
—
0
0
17
215
0.79
0.39
1.4
1.6
7.58
7.60
mmol/l
0.02
17
208
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
11
80
1.38
0.38
1.3
1.3
5.27
6.20
mmol/l
1.50
11
74
5
36
1.39
0.38
4.0
1.4
—
—
—
0
0
5
36
1.39
0.38
4.0
1.4
—
—
—
0
0
32
271
1.18
0.37
1.6
1.7
12711.86
10409.07
e6/l
0.19
21
199
47
535
0.87
0.37
1.2
1.3
—
—
—
0
0
14
107
1.31
0.37
4.1
1.8
—
—
—
0
0
5
37
1.35
0.37
4.0
1.9
—
—
—
0
0
76
688
1.11
0.36
1.6
1.7
4.02
4.12
mg/l
0.03
55
492
10
135
0.74
0.36
1.1
1.1
5.16
5.70
iu/ml
—
5
43
11
81
1.36
0.36
1.3
1.1
—
—
—
0
0
12
90
1.34
0.36
1.0
1.1
1453.00
1531.95
miu/ml
0.11
12
90
6
42
1.43
0.35
1.0
1.1
—
83.91
—
0
11
62
689
0.90
0.34
1.6
1.8
—
—
—
0
0
15
118
1.27
0.33
3.9
1.7
—
—
—
0
0
43
378
1.14
0.33
1.3
1.2
—
—
—
0
0
20
164
1.22
0.32
1.1
1.2
17.31
20.09
u/l
0.24
14
142
11
83
1.33
0.32
1.4
1.3
5.75
6.72
u/l
0.37
11
70
19
156
1.22
0.31
1.3
1.1
—
—
—
0
0
33
287
1.15
0.30
1.0
1.1
2.09
2.19
eliau/ml
0.05
17
153
22
185
1.19
0.29
1.3
1.2
—
—
—
0
0
10
76
1.32
0.28
1.6
1.2
—
—
—
0
0
45
403
1.12
0.28
1.1
1.1
1.85
1.33
u/ml
0.13
20
168
8
64
1.25
0.27
1.4
1.5
35.25
29.21
umol/l
—
8
56
8
66
1.21
0.26
1.1
1.2
123.75
107.30
%
—
8
57
42
377
1.12
0.25
1.2
1.2
—
—
—
0
0
13
105
1.24
0.25
1.0
1.2
—
185.00
—
0
16
75
806
0.93
0.24
1.4
1.5
—
—
—
0
0
12
97
1.24
0.23
1.1
1.1
—
—
—
0
0
5
40
1.25
0.22
1.2
1.1
—
—
—
0
0
15
125
1.20
0.22
1.1
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
7.2
—
10.54
—
0
11
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
3.65
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
15
126
1.19
0.21
1.5
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
4.0
—
25.23
—
0
13
10
80
1.25
0.20
1.2
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.8
—
7.87
—
0
8
13
108
1.21
0.20
1.2
1.3
—
—
—
0
0
6
49
1.23
0.20
1.3
1.4
—
—
—
0
0
46
423
1.09
0.19
1.1
1.1
5.24
6.15
u/ml
0.10
21
237
24
214
1.12
0.17
2.0
1.4
—
—
—
0
0
5
67
0.75
0.17
1.0
1.2
—
20.27
—
0
11
93
886
1.05
0.16
4.1
4.5
4.28
28.96
ug/l
1.49
72
679
94
897
1.05
0.16
1.4
1.4
—
—
—
0
0
21
235
0.89
0.16
1.3
1.4
6.77
7.02
mmol/l
0.34
21
211
6
79
0.76
0.15
2.3
1.7
—
733933.17
—
0
6
39
361
1.08
0.15
2.7
2.3
4.65
4.69
umol/l
0.02
28
267
51
478
1.07
0.15
1.2
1.1
0.40
2.82
u/ml
5.55
27
250
9
82
1.10
0.15
4.1
3.7
—
—
—
0
0
70
665
1.06
0.14
1.9
2.0
4.86
6.38
iu/ml
0.23
12
161
8
98
0.82
0.13
1.3
1.2
17.50
7.89
mm/h
—
8
98
603
6100
0.98
0.13
2.9
2.6
—
—
estimate
—
0
0
216
2110
1.03
0.12
2.3
2.1
—
—
—
0
0
79
823
0.96
0.12
1.5
1.5
—
—
—
0
0
18
162
1.11
0.12
1.4
1.2
—
—
—
0
0
360
3547
1.02
0.11
1.6
1.6
—
—
—
0
0
40
377
1.06
0.11
1.9
1.5
—
—
—
0
0
180
1761
1.03
0.10
2.0
2.0
—
—
—
0
0
38
359
1.06
0.10
1.1
1.1
0.95
4.59
u/ml
3.45
17
170
5
45
1.11
0.09
1.6
1.5
8.69
7.87
ug/l
—
5
45
14
126
1.11
0.09
1.1
1.0
—
—
—
0
0
12
107
1.12
0.08
1.2
1.3
—
—
—
0
0
39
407
0.96
0.06
1.2
1.1
0.60
1.74
u/ml
2.03
20
197
17
158
1.08
0.06
1.4
1.2
—
—
—
0
0
30
290
1.04
0.03
1.4
1.2
—
—
—
0
0
14
132
1.06
0.02
1.4
1.1
—
—
—
0
0
34
332
1.02
0.01
1.1
1.1
3.93
5.00
u/ml
0.17
13
138
31
317
0.98
0.01
4.4
3.9
63.20
1317.20
u/ml
1.42
25
278
24
236
1.02
0.00
3.7
3.4
15.82
22.77
mg/l
1.08
16
159
14
138
1.01
0.00
1.4
1.1
—
—
—
0
0
59
594
0.99
0.00
1.4
1.6
15.15
9.09
u/ml
—
10
162
28
282
0.99
0.00
1.3
1.3
—
—
—
0
0
14
137
1.02
0.00
1.4
1.1
—
—
—
0
0
32
315
1.02
0.00
1.1
1.0
0.06
0.19
u/ml
1.20
11
92
14
135
1.04
0.00
1.4
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
7.51
—
0
7
0
6
0.00
0.00
0.0
6.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
14
140
1.00
-0.00
1.4
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
5.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
26.50
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPERPRO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERPRO | 1.537 [1.32, 1.79] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.271 |
During the follow-up period (1.1.1998 — 31.12.2019), 228 out of 5615 females with E4_HYPERPRO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERPRO | 1.183 [1.0, 1.41] | 0.056 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 183 out of 1157 males with E4_HYPERPRO died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPERPRO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.122% | 0.213% |
| 5 | 0.784% | 1.263% |
| 10 | 2.184% | 3.222% |
| 15 | 4.019% | 6.2% |
| 20 | 7.392% | 10.984% |
Relationships between endpoints
↥Index endpoint: E4_HYPERPRO – Hyperprolactinaemia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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