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Lactose intolerance, other/unspecified

DOID EFO Endpoint Browser PheWeb

E4_LACTONAS

lactose intolerance: Inability to fully digest and absorb lactose due to limited or no lactase activity in the small intestine. Congenital intolerance is inherited following an autosomal recessive pattern but is rare. It is more often due to a gradual decline of lactase production in adulthood following the ingestion of fewer lactose-containing foods or secondary to an intestinal mucosal brush-border injury. Prevalence is highest among Asians, Native Americans and Africans. Clinical signs include abdominal cramping, bloating, flatulence and diarrhea following the dietary intake of lactose.

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Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E73.8, E73.9
  • Hospital discharge: ICD-9 — 2713A
  • Cause of death: ICD-10 — E73.8, E73.9
  • Cause of death: ICD-9 — 2713A

2 out of 7 registries used, show all original rules.

1242

4. Check minimum number of events

None

1242

5. Include endpoints

None

1242

6. Filter based on genotype QC (FinnGen only)

1089

Control definitions (FinnGen only)

Control exclude
E4_METABOLIA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10993 6393 4499
Only index persons 8968 5282 3686
Unadjusted period prevalence (%)
Whole population 0.16 0.18 0.13
Only index persons 0.17 0.19 0.14
Median age at first event (years)
Whole population 34.08 43.09 20.61
Only index persons 30.81 38.17 20.25

-FinnGen-

Key figures

All Female Male
Number of individuals 1089 750 339
Unadjusted period prevalence (%) 0.23 0.27 0.16
Median age at first event (years) 42.96 42.30 44.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1166
Matched controls
11660
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
2713A
ICD-9 Finland
Disorders of carbohydrate transport and metabolism, Intestinal disaccharidase deficiencies and disaccharide malabsorption[MALABSORPTIO LACTOSI]
+∞
307.7
296
*
E73.9
ICD-10 Finland
Lactose intolerance, unspecified
2403.2
307.7
594
5
E73.8
ICD-10 Finland
Other lactose intolerance
3939.7
307.7
308
*
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
7.3
119.8
194
310
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.4
93.5
637
3032
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.4
84.1
465
1923
A06AC01
ATC
ispaghula (psylla seeds); oral
3.3
82.0
451
1855
UJF32
NOMESCO Finland
Coloscopy
3.2
73.7
409
1674
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
3.9
71.5
253
776
K90.0
ICD-10 Finland
Coeliac disease
6.8
55.3
90
142
A02BC05
ATC
esomeprazole; systemic
2.5
48.5
545
3068
C10AC01
ATC
colestyramine; oral
6.7
45.7
75
119
K59.1
ICD-10 Finland
Functional diarrhoea
4.2
44.8
127
327
A03CA02
ATC
clidinium and psycholeptics; oral
4.6
43.5
110
259
A02BC01
ATC
omeprazole; systemic
2.5
43.0
382
1911
K30
ICD-10 Finland
Functional dyspepsia
3.1
42.5
203
738
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.4
40.6
374
1894
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
5.5
40.0
80
154
UJD02
NOMESCO Finland
Gastroscopy
4.8
39.4
94
211
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
5.1
38.5
83
171
A02BC03
ATC
lansoprazole; oral
2.3
37.3
374
1955
N03AX16
ATC
[U] pregabalin
2.5
36.5
301
1440
A02BA02
ATC
ranitidine; systemic
2.6
36.2
264
1192
A02BC02
ATC
pantoprazole; systemic
2.3
35.5
814
5887
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
3.2
34.8
151
516
E73
ICD-10 Finland
Lactose intolerance
40.6
34.5
43
11
R07.4
ICD-10 Finland
Chest pain, unspecified
2.2
31.9
346
1849
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.9
31.7
166
630
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
31.5
417
2410
P01AB01
ATC
metronidazole; oral, rectal
2.1
31.1
516
3242
J01MA02
ATC
ciprofloxacin; systemic
2.1
31.0
460
2771
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.4
31.0
270
1313
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.3
30.5
278
1378
A03FA02
ATC
cisapride; oral, rectal
3.3
29.7
120
391
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
9.5
29.3
35
38
D06
ICPC
Abdominal pain localized other
2.9
28.7
150
567
M79.6
ICD-10 Finland
Pain in limb
2.0
28.5
565
3745
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
4.2
28.3
78
196
Z71.8
ICD-10 Finland
Other specified counselling
2.0
28.1
458
2832
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
27.7
299
1583
N06AX21
ATC
duloxetine; oral
2.6
26.9
182
785
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
3.7
26.7
89
256
N02AX02
ATC
tramadol; systemic, rectal
2.0
26.6
495
3191
R06.0
ICD-10 Finland
Dyspnoea
2.1
26.2
339
1918
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
9.9
26.0
30
31
L17
ICPC
Foot/toe symptom/complaint
2.0
25.8
397
2389
R01AD09
ATC
mometasone; nasal
1.9
25.8
580
3969
R01AD08
ATC
fluticasone; nasal
2.0
25.6
369
2169
D01
ICPC
Abdominal pain/cramps general
2.4
25.4
204
950
J02AC01
ATC
fluconazole; systemic
1.9
25.4
505
3313
R42
ICD-10 Finland
Dizziness and giddiness
2.1
25.4
287
1541
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
25.3
521
3457
L03
ICPC
Low back symptom/complaint
2.0
25.3
391
2355
R51.80
ICD-10 Finland
Headache
2.2
25.2
246
1245
K29.3
ICD-10 Finland
Chronic superficial gastritis
4.8
24.7
57
124
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.3
24.5
64
154
D11
ICPC
Diarrhoea
2.4
24.0
194
905
R52.9
ICD-10 Finland
Pain, unspecified
2.6
24.0
154
646
A02BC04
ATC
rabeprazole; oral
2.8
23.8
130
502
E87.6
ICD-10 Finland
Hypokalaemia
7.2
23.4
35
50
H02AB04
ATC
methylprednisolone; systemic
2.4
23.2
188
878
R03AC02
ATC
salbutamol; inhalant
1.9
22.9
685
5059
Z3226
NOMESCO Finland
Physiotherapist
2.2
22.9
232
1189
M54.5
ICD-10 Finland
Low back pain
1.9
22.8
457
2978
A07EC02
ATC
mesalazine; oral, rectal
3.3
22.7
90
289
G47.3
ICD-10 Finland
Sleep apnoea
2.1
22.7
260
1397
M03BX02
ATC
tizanidine; oral
1.9
22.1
720
5433
R06AE07
ATC
cetirizine; oral
1.8
22.0
553
3857
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.9
21.8
344
2067
N05BA04
ATC
oxazepam; oral
1.9
21.4
333
1990
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.2
21.0
207
1046
N06AB04
ATC
citalopram; systemic
2.0
20.7
257
1418
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.9
20.6
375
2354
L28
ICPC
Limited function/disability (L)
2.1
20.6
220
1147
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.0
20.5
97
346
A07DA03
ATC
loperamide; oral
4.2
20.3
55
136
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
20.1
496
3412
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
20.1
247
1357
L01
ICPC
Neck symptom/complaint
2.1
20.0
223
1181
R53
ICD-10 Finland
Malaise and fatigue
1.9
20.0
328
1989
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
19.8
176
851
M79.7
ICD-10 Finland
Fibromyalgia
3.7
19.8
65
185
K59.09
ICD-10 Finland
Constipation, unspecified
2.9
19.7
95
342
M54.4
ICD-10 Finland
Lumbago with sciatica
2.1
19.6
231
1248
N03AX12
ATC
[U] gabapentin; oral
2.2
19.5
193
975
Z01.2
ICD-10 Finland
Dental examination
1.8
19.3
588
4280
EB1AA, ,
SPAT
2.8
18.9
96
356
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.6
18.8
120
500
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.2
18.8
179
890
A06AC51
ATC
ispaghula, combinations; oral
3.3
18.7
73
232
N05AH04
ATC
quetiapine; oral
2.0
18.7
242
1349
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.2
18.7
186
940
M01AE03
ATC
ketoprofen; systemic, rectal
1.8
18.5
402
2648
R4110
NOMESCO Finland
Physiotherapy
1.9
18.5
311
1894
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.2
18.4
178
891
SPAT1336
SPAT
Request for examination
3.6
18.2
60
171
N06AX11
ATC
mirtazapine; oral
1.8
18.2
408
2709
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.5
18.1
123
528
H02AB06
ATC
prednisolone; systemic
1.7
18.0
529
3790
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.7
17.9
100
390
E73.0
ICD-10 Finland
Congenital lactase deficiency
+∞
17.7
17
*
J01DA01
ATC
[U] cefalexin
1.7
17.7
705
5476
WX110, ,
SPAT
2.9
17.7
89
328
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.0
17.6
215
1173
C05AA08
ATC
fluocortolone; rectal, topical
2.2
17.4
159
776
U07
ICPC
Urine symptom/complaint other
2.5
17.3
117
501
N06AA09
ATC
amitriptyline; systemic
2.5
17.1
117
504
N06AX16
ATC
venlafaxine; oral
2.1
17.0
191
1011
M01AB05
ATC
diclofenac; systemic, rectal
1.7
16.9
727
5734
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.7
16.7
96
380
SPAT1212
SPAT
Extensive examination of musculoskeletal system
2.6
16.6
101
411
J01FA10
ATC
azithromycin; systemic
1.7
16.5
703
5512
C10AX09
ATC
ezetimibe; oral
2.2
16.5
144
690
C01DA14
ATC
isosorbide mononitrate; oral
2.3
16.3
131
605
H04.10
ICD-10 Finland
Dry eye syndrome
2.2
16.2
159
797
G44.2
ICD-10 Finland
Tension-type headache
2.0
16.2
186
990
J01AA02
ATC
doxycycline; systemic
1.8
16.2
858
7125
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
11.9
16.1
29
25
M25.5
ICD-10 Finland
Pain in joint
1.7
16.0
403
2743
M79.1
ICD-10 Finland
Myalgia
2.0
15.9
205
1136
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.8
15.9
327
2102
UJF30
NOMESCO Finland
Ileoscopy through colon
2.3
15.8
128
594
R02
ICPC
Shortness of breath/dyspnoea
2.1
15.7
165
850
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.0
15.5
195
1072
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
4.0
15.5
44
113
C07AA05
ATC
propranolol; systemic
1.8
15.4
258
1557
L02
ICPC
Back symptom/complaint
2.2
15.3
147
731
R19.4
ICD-10 Finland
Change in bowel habit
3.8
15.3
47
128
A99
ICPC
Disease/condition unspecnature/site
2.2
15.0
136
660
R05
ICPC
Cough
1.8
15.0
311
1999
A01
ICPC
Pain general/multiple sites
2.2
15.0
129
614
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.5
14.9
101
432
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.7
14.9
468
3362
A97
ICPC
No disease
1.8
14.9
252
1525
5790A
ICD-9 Finland
Intestinal malabsorption, Coeliac disease
32.2
14.8
19
6
A07EC01
ATC
sulfasalazine; oral, rectal
2.4
14.8
108
478
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
14.8
646
5036
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
14.8
238
1418
M01AE02
ATC
naproxen; oral, rectal
1.6
14.8
671
5283
E86
ICD-10 Finland
Volume depletion
21.4
14.7
21
10
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
14.6
178
966
R06AX27
ATC
desloratadine; oral
1.7
14.6
366
2478
A06AD11
ATC
lactulose; oral
2.1
14.6
160
837
A07EA06
ATC
budesonide; oral, local oral
3.1
14.5
60
198
M02AA10
ATC
ketoprofen; topical
2.0
14.3
176
958
C10AA05
ATC
atorvastatin; oral
1.7
14.3
355
2396
A02BA03
ATC
famotidine; systemic
3.5
14.2
49
144
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.7
14.2
78
301
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
14.2
467
3383
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
14.2
161
851
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.1
14.2
153
794
R07.3
ICD-10 Finland
Other chest pain
2.2
14.2
129
627
L48
ICPC
Musculoskeletal, Clarification/discussion RFE/demand
6.5
14.1
23
36
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.1
14.1
139
697
N05BA01
ATC
diazepam; systemic, rectal
2.1
14.1
154
803
K58
ICD-10 Finland
Irritable bowel syndrome
3.5
14.1
49
145
J01FA06
ATC
roxithromycin; oral
1.6
14.0
434
3095
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.1
13.9
150
778
N05CF02
ATC
zolpidem; oral
1.9
13.9
205
1185
M03BC51
ATC
orphenadrine, combinations; systemic
1.7
13.9
302
1963
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.8
13.8
258
1605
5641A
ICD-9 Finland
Functional digestive disorders, not elsewhere classified, Irritable colon
24.1
13.8
19
8
1310
FHL
Esophagogastroscopy
24.1
13.8
19
8
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.6
13.7
540
4078
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
2.6
13.6
82
332
M02AA07
ATC
piroxicam; topical
1.7
13.5
373
2578
R03AC03
ATC
terbutaline; inhalant
2.0
13.5
166
904
R12
ICD-10 Finland
Heartburn
2.2
13.4
114
539
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.3
13.4
107
493
EB1SA, ,
SPAT
2.7
13.4
75
293
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
13.4
212
1254
J01FF01
ATC
clindamycin; systemic
1.7
13.2
295
1927
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
13.2
602
4693
XQ800
NOMESCO Finland
Prick test
2.3
13.2
106
490
S01GX01
ATC
cromoglicic acid; ophthalmic
1.8
13.1
257
1618
S29
ICPC
Skin symptom/complaint other
1.8
13.1
240
1483
AA1AD
NOMESCO Finland
CT of head and brain
1.7
13.1
279
1800
J01FA09
ATC
clarithromycin; systemic
1.6
13.0
362
2503
N06AB03
ATC
fluoxetine; oral
2.0
12.9
148
785
M01AH01
ATC
celecoxib; oral
1.9
12.9
190
1098
Z01.7
ICD-10 Finland
Laboratory examination
1.8
12.8
201
1183
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.7
12.8
335
2279
C03CA01
ATC
furosemide; systemic
1.7
12.8
267
1711
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.1
12.7
126
633
J01EA01
ATC
trimethoprim; systemic
1.7
12.7
304
2020
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
12.7
270
1739
N05CF01
ATC
zopiclone; oral
1.7
12.7
337
2302
L13
ICPC
Hip symptom/complaint
1.8
12.6
218
1322
UKC02
NOMESCO Finland
Cystoscopy
2.0
12.6
150
806
U02
ICPC
Urinary frequency/urgency
1.9
12.5
185
1068
Z2221
NOMESCO Finland
Medical doctor
1.7
12.5
303
2018
H02AB07
ATC
prednisone; oral
2.0
12.5
151
815
C07AB07
ATC
bisoprolol; oral
1.6
12.5
450
3306
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.9
12.5
162
896
C10AA07
ATC
rosuvastatin; oral
1.7
12.5
302
2011
J45
ICD-10 Finland
Asthma
2.1
12.4
130
667
J01MA12
ATC
levofloxacin; systemic
1.9
12.4
187
1088
A11
ICPC
Chest pain NOS
2.3
12.4
94
424
N02BE01
ATC
paracetamol; systemic, rectal
1.9
12.2
1000
8913
N17
ICPC
Vertigo/dizziness
1.9
12.2
155
852
R03BA02
ATC
budesonide; inhalant
1.8
12.2
216
1319
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
12.2
464
3450
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
12.1
164
921
Z3231
NOMESCO Finland
Registered nurse
1.7
12.1
294
1960
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
10.2
12.0
23
23
R01BA52
ATC
pseudoephedrine, combinations; oral
1.6
12.0
316
2149
M03BC01
ATC
orphenadrine (citrate); systemic
1.7
11.9
250
1602
M54.3
ICD-10 Finland
Sciatica
2.6
11.8
71
287
A02BX02
ATC
sucralfate; oral
3.0
11.8
51
173
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
9.1
11.8
24
27
N02BF02
ATC
pregabalin; oral
2.4
11.8
83
362
JAH01
NOMESCO Finland
Laparoscopy
2.8
11.8
61
229
N06AB10
ATC
escitalopram; oral
1.7
11.7
252
1624
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.9
11.7
154
856
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
11.7
386
2770
AN1
HP
Coronary angiography
2.4
11.6
78
333
WX290, ,
SPAT
3.0
11.6
51
175
N05CD07
ATC
temazepam; oral
2.0
11.5
123
635
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.5
11.5
70
285
N01
ICPC
Headache
1.8
11.5
173
1005
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
3.9
11.4
33
86
ZXE00
NOMESCO Finland
One hour or less
1.6
11.4
415
3042
D82
ICPC
Teeth/gum disease
1.6
11.4
444
3305
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
1.9
11.4
142
775
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.1
11.4
115
582
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
2.2
11.4
102
493
K50.9
ICD-10 Finland
Crohn disease, unspecified
4.4
11.3
28
65
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.9
11.3
155
874
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
1.9
11.2
151
845
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.2
11.2
93
435
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
4.2
11.1
29
70
R01AD12
ATC
fluticasone furoate; nasal
1.6
11.1
374
2690
R01AD58
ATC
fluticasone, combinations; nasal
1.6
11.1
303
2073
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.1
11.1
114
581
M54.2
ICD-10 Finland
Cervicalgia
2.1
11.1
103
505
R05
ICD-10 Finland
Cough
1.7
11.0
250
1631
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.0
11.0
119
618
J01DB01
ATC
cefalexin; oral
1.7
10.9
926
8150
104
Kela drug reimbursment
Thyroid insufficiency
2.4
10.9
77
336
G04BD07
ATC
tolterodine; oral
2.7
10.9
57
215
UJD10, ,
SPAT
3.4
10.9
39
118
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.1
10.9
109
550
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.8
10.9
55
204
N30.0
ICD-10 Finland
Acute cystitis
1.7
10.9
206
1280
K02.1
ICD-10 Finland
Caries of dentine
1.5
10.7
674
5532
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.0
10.7
126
673
K50.1
ICD-10 Finland
Crohn disease of large intestine
5.6
10.7
20
36
M01AX17
ATC
nimesulide; oral
1.7
10.7
235
1519
A28
ICPC
Limited function/disability NOS
1.8
10.7
165
964
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.9
10.7
49
172
J31.0
ICD-10 Finland
Chronic rhinitis
2.1
10.7
110
561
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
3.1
10.6
45
151
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
10.6
215
1360
SFC01
NOMESCO Finland
Additional procedure necessary for restorative treatment
1.6
10.6
294
2017
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.5
10.5
608
4896
N05BE01
ATC
buspirone; oral
3.2
10.5
42
136
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.7
10.4
57
220
SFA20
NOMESCO Finland
Two-surface restoration
1.5
10.4
654
5352
R06.5
ICD-10 Finland
Mouth breathing
2.1
10.4
98
483
R03AK07
ATC
formoterol and budesonide; inhalant
1.7
10.3
240
1573
JN3AD
NOMESCO Finland
Abdominal CT examination
1.9
10.3
133
733
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.8
10.3
163
960
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.8
10.2
158
923
N03AE01
ATC
clonazepam; systemic
2.5
10.2
67
283
R10.0
ICD-10 Finland
Acute abdomen
3.1
10.2
43
144
WX402
NOMESCO Finland
General anaesthesia
1.7
10.2
237
1554
D03
ICPC
Heartburn
2.7
10.1
53
200
S21
ICPC
Skin texture symptom/complaint
1.8
10.1
175
1057
M54
ICD-10 Finland
Dorsalgia
1.8
10.1
152
881
J45.1
ICD-10 Finland
Nonallergic asthma
2.2
10.1
84
394
K50.8
ICD-10 Finland
Other Crohn disease
4.0
10.1
28
71
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.8
10.1
151
874
B60
ICPC
Blood and Immunity, Result test/procedure
5.1
10.1
21
42
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
3.3
10.1
37
114
P06
ICPC
Sleep disturbance
1.8
10.0
156
914
UJF32, ,
SPAT
2.9
10.0
46
162
N06AB06
ATC
sertraline; oral
1.8
10.0
147
846
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
2.5
9.9
65
274
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
9.9
354
2568
A08
ICPC
Swelling
2.4
9.9
67
287
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
1.9
9.8
129
715
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
9.8
411
3083
K08.80
ICD-10 Finland
Toothache NOS
1.9
9.8
121
657
R06AX22
ATC
ebastine; oral
1.7
9.8
199
1258
SAA01
NOMESCO Finland
Simple examination of mouth
1.5
9.8
822
7103
M01AH02
ATC
rofecoxib; oral
1.9
9.7
125
688
ZXD20
NOMESCO Finland
Day surgery
1.8
9.7
140
801
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.3
9.7
72
322
WX002
NOMESCO Finland
Sedation and analgesia
1.7
9.7
187
1166
N06AX22
ATC
agomelatine; oral
3.3
9.6
36
112
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
9.6
462
3561
B01AC04
ATC
clopidogrel; oral
2.0
9.6
116
625
M51.9
ICD-10 Finland
Intervertebral disc disorder, unspecified
4.4
9.6
24
56
ZXD05
NOMESCO Finland
Urgent procedure
1.6
9.6
307
2170
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
3.1
9.6
39
128
T36
ICD-10 Finland
Poisoning by systemic antibiotics
2.6
9.6
56
224
A03DA02
ATC
pitofenone and analgesics; systemic
4.1
9.5
26
65
H03BB01
ATC
carbimazole; oral
2.9
9.5
45
161
E0000UV, ,
ATC
1.5
9.5
470
3644
R52.2
ICD-10 Finland
Other chronic pain
2.7
9.4
49
185
F34.1
ICD-10 Finland
Dysthymia
2.7
9.4
50
191
R03DC03
ATC
montelukast; oral
1.7
9.4
194
1232
T78.3
ICD-10 Finland
Angioneurotic oedema
4.4
9.4
23
53
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
2.5
9.3
60
251
U01
ICPC
Dysuria/painful urination
2.0
9.3
102
531
B03BA03
ATC
hydroxocobalamin; parenteral
2.5
9.3
59
245
R11
ICD-10 Finland
Nausea and vomiting
2.0
9.3
105
553
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.6
9.3
281
1960
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
9.2
253
1723
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
9.2
211
1374
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.5
9.2
57
234
L04AX03
ATC
methotrexate; systemic
1.9
9.2
113
612
G04BD08
ATC
solifenacin; oral
2.4
9.2
66
290
V700A
ICD-9 Finland
General medical examination, Routine general medical examination at a health care facility
3.2
9.2
35
110
D19
ICPC
Teeth/gum symptom/complaint
1.5
9.2
361
2663
N39.3
ICD-10 Finland
Stress incontinence
2.1
9.2
86
422
M01AX01
ATC
nabumetone; oral
2.7
9.2
49
187
M50.3
ICD-10 Finland
Other cervical disc degeneration
3.8
9.2
28
76
Z71.9
ICD-10 Finland
Counselling, unspecified
2.0
9.2
96
492
K59.0
ICD-10 Finland
Constipation
2.3
9.2
66
291
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
9.1
207
1345
M54.6
ICD-10 Finland
Pain in thoracic spine
2.1
9.1
92
465
H03AA01
ATC
levothyroxine sodium; systemic
1.6
9.1
249
1694
A07AA02
ATC
nystatin; oral
2.3
9.1
66
292
K50.0
ICD-10 Finland
Crohn disease of small intestine
3.8
9.1
27
72
SFA10
NOMESCO Finland
One-surface restoration
1.5
9.1
616
5063
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.0
9.0
98
509
M05BA04
ATC
alendronic acid; oral
2.0
9.0
95
488
D64.9
ICD-10 Finland
Anaemia, unspecified
2.0
9.0
100
524
A62
ICPC
General and Unspecified, Administrative procedure
3.2
9.0
34
107
C07AB02
ATC
metoprolol; systemic
1.7
8.9
174
1087
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.8
8.9
148
884
A04
ICPC
Weakness/tiredness general
1.7
8.9
185
1176
K29.1
ICD-10 Finland
Other acute gastritis
4.5
8.9
21
47
R60.9
ICD-10 Finland
Oedema, unspecified
2.4
8.8
60
258
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
2.1
8.8
83
409
R50.9
ICD-10 Finland
Fever, unspecified
1.7
8.8
172
1074
R32
ICD-10 Finland
Unspecified urinary incontinence
3.0
8.8
37
124
M01AH05
ATC
etoricoxib; oral
1.5
8.8
667
5585
L08
ICPC
Shoulder symptom/complaint
1.6
8.8
242
1649
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.6
8.8
252
1734
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.9
8.8
123
697
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
8.7
151
911
D02
ICPC
Abdominal pain epigastric
2.1
8.7
82
404
L15
ICPC
Knee symptom/complaint
1.5
8.7
280
1976
R20.2
ICD-10 Finland
Paraesthesia of skin
2.1
8.7
85
425
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
3.5
8.7
29
84
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.0
8.7
100
531
M53.0
ICD-10 Finland
Cervicocranial syndrome
1.9
8.6
111
611
C10AA01
ATC
simvastatin; oral
1.5
8.6
302
2170
J01AA04
ATC
lymecycline; systemic
1.7
8.6
153
930
R60.0
ICD-10 Finland
Localized oedema
1.8
8.6
124
708
N02BF01
ATC
gabapentin; oral
1.9
8.6
112
619
R03BA05
ATC
fluticasone; inhalant
1.6
8.6
206
1356
K03.82
ICD-10 Finland
Split tooth for reasons other than trauma
1.5
8.6
306
2207
R05FB02
ATC
cough suppressants and expectorants; systemic
1.5
8.6
366
2741
R13
ICD-10 Finland
Dysphagia
2.2
8.6
75
359
R15
ICD-10 Finland
Faecal incontinence
3.0
8.6
37
126
R63.4
ICD-10 Finland
Abnormal weight loss
2.7
8.5
46
177
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.1
8.5
82
408
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
2.3
8.5
66
301
G04BD12
ATC
mirabegron; oral
1.9
8.5
118
667
J45.8
ICD-10 Finland
Mixed asthma
2.9
8.4
39
138
K02.2
ICD-10 Finland
Caries of cementum
2.5
8.4
54
226
T45
ICPC
Metabolic, Observ/health educat/advice/diet
4.3
8.4
21
49
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
2.8
8.4
40
144
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
2.7
8.4
44
167
SAA02
NOMESCO Finland
Basic examination of mouth
1.5
8.4
769
6646
R5140
NOMESCO Finland
Monitoring the use of the aid
1.9
8.4
108
596
R00.2
ICD-10 Finland
Palpitations
1.9
8.3
100
538
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
8.3
802
6990
H53.1
ICD-10 Finland
Subjective visual disturbances
2.1
8.3
77
377
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
2.0
8.3
86
439
SFA30
NOMESCO Finland
Three-surface restoration
1.5
8.3
437
3404
U72
ICPC
Urethritis
3.2
8.3
32
102
A01AB04
ATC
amphotericin B; local oral
2.5
8.3
53
222
J37.0
ICD-10 Finland
Chronic laryngitis
2.7
8.2
42
157
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.6
8.2
200
1321
C10AX13
ATC
evolocumab; parenteral
14.6
8.2
13
9
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
2.3
8.2
63
286
F29
ICPC
Eye symptom/complaint other
1.8
8.2
125
727
R01AD05
ATC
budesonide; nasal
2.0
8.2
87
449
T78.4
ICD-10 Finland
Allergy, unspecified
2.3
8.2
62
280
R41.3
ICD-10 Finland
Other amnesia
3.2
8.1
32
103
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.6
8.1
230
1575
M05BA07
ATC
risedronic acid; oral
2.9
8.1
37
130
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
2.2
8.1
64
294
R74
ICPC
Upper respiratory infection acute
1.5
8.1
405
3122
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
1.8
8.1
119
684
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.3
8.1
61
275
A03FA01
ATC
metoclopramide; systemic, rectal
1.6
8.1
236
1628
5301A
ICD-9 Finland
Diseases of oesophagus, Oesophagitis[OESOPHAGITIS REFLUENS]
9.0
8.0
16
18
N76.0
ICD-10 Finland
Acute vaginitis
2.0
8.0
92
487
R51
ICD-10 Finland
Headache
2.1
8.0
74
362
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
3.9
8.0
23
60
I25.2
ICD-10 Finland
Old myocardial infarction
2.6
8.0
45
177
D07AA02
ATC
hydrocortisone; topical
1.7
8.0
166
1053
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.8
8.0
128
756
R21
ICPC
Throat symptom/complaint
1.5
7.9
272
1942
R52.0
ICD-10 Finland
Acute pain
2.6
7.9
44
172
A01AB09
ATC
miconazole; local oral
1.9
7.9
95
512
3015
Kela drug reimbursment
Alirocumab and evolocumab for the treatment of hypercholesterolaemia and dyslipidaemia
13.1
7.9
13
10
D29
ICPC
Digestive symptom/complaint other
3.0
7.8
33
111
E66.00
ICD-10 Finland
Metabolic syndrome
2.4
7.8
53
228
D62
ICPC
Digestive, Administrative procedure
10.9
7.8
14
13
N30
ICD-10 Finland
Cystitis
1.9
7.8
104
580
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.8
7.8
123
723
K20
ICD-10 Finland
Oesophagitis
4.2
7.8
20
48
SPAT1342
SPAT
Referral to specialised care
4.2
7.8
20
48
M70.6
ICD-10 Finland
Trochanteric bursitis
1.7
7.7
145
895
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
3.6
7.7
25
71
M01AX05
ATC
glucosamine; oral
1.6
7.7
171
1103
R03BB04
ATC
tiotropium bromide; inhalant
1.9
7.7
92
495
K21
ICD-10 Finland
Gastro-oesophageal reflux disease
2.0
7.7
77
389
N05AA02
ATC
levomepromazine; systemic
2.5
7.7
48
199
M54.1
ICD-10 Finland
Radiculopathy
2.6
7.7
43
169
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.9
7.6
105
591
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.3
7.6
55
243
7879X
ICD-9 Finland
Symptoms involving digestive system, Other symptoms involving digestive system
8.1
7.6
16
20
K57.9
ICD-10 Finland
Diverticular disease of intestine, part unspecified, without perforation or abscess
3.1
7.6
30
97
R5110, ,
SPAT
2.0
7.6
85
447
1370
FHL
Colonoscopy, whole colon
11.9
7.6
13
11
D07AC13
ATC
mometasone; topical
1.5
7.6
297
2178
R06AX26
ATC
fexofenadine; oral
2.0
7.6
84
440
5645A
ICD-9 Finland
Functional digestive disorders, not elsewhere classified, Functional diarrhoea
25.2
7.6
10
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.0
7.6
79
405
M01AC06
ATC
meloxicam; systemic, rectal
1.5
7.6
356
2706
F61.0
ICD-10 Finland
Mixed personality disorders
3.4
7.6
26
77
R06AE09
ATC
levocetirizine; oral
1.7
7.5
164
1052
G03CA04
ATC
estriol; systemic, vaginal
2.1
7.5
72
357
F32
ICD-10 Finland
Depressive episode
2.1
7.5
72
357
J01DA09
ATC
[U] cefadroxil
1.5
7.5
272
1961
EBA00, ,
SPAT
2.8
7.5
37
136
I20.09
ICD-10 Finland
Unstable angina
2.5
7.5
44
177
M48.0
ICD-10 Finland
Spinal stenosis
1.8
7.5
117
686
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
7.5
316
2353
H92.0
ICD-10 Finland
Otalgia
2.0
7.4
84
443
R4120
NOMESCO Finland
Occupational therapy
2.1
7.4
67
325
N06AX05
ATC
trazodone; oral
3.0
7.4
32
109
L86
ICPC
Back syndrome with radiating pain
2.1
7.4
68
333
S13.4
ICD-10 Finland
Sprain and strain of cervical spine
2.4
7.3
51
222
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.5
7.3
310
2306
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.6
7.3
41
161
G04BD11
ATC
fesoterodine; oral
3.1
7.3
29
94
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
3.0
7.3
32
110
ZXD35
NOMESCO Finland
Usual procedure
2.9
7.3
34
121
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
2.1
7.3
69
341
N02AJ13
ATC
tramadol and paracetamol; systemic
3.2
7.3
28
89
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.0
7.3
75
383
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.6
7.2
184
1227
R83
ICPC
Respiratory infection other
1.5
7.2
313
2339
P29
ICPC
Psychological sympt/compl other
1.8
7.2
103
587
T99
ICPC
Endocr/metab/nutrit disease other
3.7
7.2
22
60
M47.82
ICD-10 Finland
Other spondylosis, cervical region
2.4
7.2
46
193
N06AB05
ATC
paroxetine; oral
2.1
7.2
66
323
G04CA01
ATC
alfuzosin; oral
1.9
7.2
85
456
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
3.6
7.2
23
65
N05AF03
ATC
chlorprothixene; systemic
3.0
7.2
31
106
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
2.3
7.1
52
231
A10AB05
ATC
insulin aspart; parenteral
2.1
7.1
70
352
D07AB02
ATC
hydrocortisone butyrate; topical
1.5
7.1
318
2391
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.5
7.1
44
182
XF402
NOMESCO Finland
ECG with work load test
1.9
7.1
84
451
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
1.9
7.1
88
480
J20
ICD-10 Finland
Acute bronchitis
1.8
7.0
114
675
N03AG01
ATC
valproic acid; systemic, rectal
2.0
7.0
70
353
I20.99
ICD-10 Finland
Angina pectoris, unspecified
2.3
7.0
50
220
S18
ICPC
Laceration/cut
1.4
7.0
468
3775
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
1.8
7.0
112
660
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
7.0
519
4261
SXC05
NOMESCO Finland
Other oral or dental procedure
1.9
7.0
90
496
FN1AT
NOMESCO Finland
Endovascular dilatation of coronary arteries (PTCA)
2.8
7.0
34
124
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
3.0
7.0
30
102
I84.9
ICD-10 Finland
Unspecified hemorrhoids without complication
2.4
6.9
45
190
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.5
6.9
235
1670
R07.0
ICD-10 Finland
Pain in throat
1.9
6.9
87
476
7819X
ICD-9 Finland
Symptoms involving nervous and musculoskeletal systems, Other symptoms involving nervous and musculoskeletal systems[SYMPTOMATA ALIA SYSTEMATIS NERVORUM ET MUSCULOSCEL]
7.6
6.9
15
20
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.3
6.9
50
222
N41.1
ICD-10 Finland
Chronic prostatitis
3.2
6.9
26
82
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.4
6.9
323
2448
P01BA02
ATC
hydroxychloroquine; oral
1.9
6.9
88
485
R03AK08
ATC
formoterol and beclometasone; inhalant
2.2
6.8
55
255
FB1AD
NOMESCO Finland
CT examination of arteria pulmonalis
2.9
6.8
31
109
X58
ICD-10 Finland
Exposure to other specified factors
1.6
6.8
169
1119
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.9
6.8
84
457
E83.50
ICD-10 Finland
Hypercalcemia
11.0
6.8
12
11
M05BX04
ATC
denosumab; parenteral
2.1
6.8
60
289
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
1.5
6.8
196
1345
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.4
6.8
44
186
X57
ICD-10 Finland
Unspecified privation
3.1
6.8
27
88
UJH02
NOMESCO Finland
Anoscopy
2.5
6.7
40
162
I20.89
ICD-10 Finland
Other angina pectoris unspecified coronary artery status
3.0
6.7
29
99
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.9
6.7
80
430
BAA60
NOMESCO Finland
Total thyroidectomy
3.4
6.7
23
68
M01AG02
ATC
tolfenamic acid; oral, rectal
1.6
6.7
161
1058
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
2.4
6.7
44
187
M01AB55
ATC
diclofenac, combinations; oral
2.0
6.7
66
332
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.5
6.7
206
1434
LCA06
NOMESCO Finland
Biopsy of endometrium
1.7
6.7
121
740
0093A
ICD-9 Finland
Ill-defined intestinal infections, Diarrhoea of presumed infectious origin
3.8
6.7
20
54
K02.0
ICD-10 Finland
Caries limited to enamel
1.5
6.6
246
1779
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.0
6.6
74
389
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
2.9
6.6
29
100
S06.0
ICD-10 Finland
Concussion
1.7
6.6
119
726
R4110, ,
SPAT
1.6
6.6
141
900
SDA04
NOMESCO Finland
Demanding periodontal treatment
1.4
6.6
310
2346
Z53.2
ICD-10 Finland
Procedure not carried out because of patient's decision for other and unspecified reasons
3.2
6.6
25
79
5355X
ICD-9 Finland
Gastritis and duodenitis, Unspecified gastritis and gastroduodenitis
12.3
6.6
11
9
SDA03
NOMESCO Finland
Periodontal treatment
1.4
6.6
437
3513
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.7
6.6
133
837
A03
ICPC
Fever
1.5
6.6
206
1439
U71
ICPC
Cystitis/urinary infection other
1.9
6.6
81
441
R06AX13
ATC
loratadine; oral
1.6
6.5
165
1097
ZXA10
NOMESCO Finland
Bilateral
1.6
6.5
175
1180
L01BA01
ATC
methotrexate; systemic
2.4
6.5
42
177
P76
ICPC
Depressive disorder
1.9
6.5
87
486
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
2.3
6.5
48
215
M75
ICD-10 Finland
Shoulder lesions
2.2
6.5
52
241
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.3
6.5
45
196
P03
ICPC
Feeling depressed
1.7
6.5
132
832
X15
ICPC
Vaginal symptom/complaint other
2.1
6.5
58
281
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
2.5
6.5
39
159
I20.90
ICD-10 Finland
Angina pectoris, unspecified
3.0
6.5
28
96
R04
ICPC
Breathing problem other
2.3
6.4
46
203
J01FA01
ATC
erythromycin; systemic
1.6
6.4
148
962
A10BH01
ATC
sitagliptin; oral
2.0
6.4
73
386
A98
ICD-10 Finland
Other viral haemorrhagic fevers, not elsewhere classified
3.4
6.4
22
65
K29.4
ICD-10 Finland
Chronic atrophic gastritis
3.3
6.4
23
70
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
1.9
6.4
75
401
103
Kela drug reimbursment
Diabetes, insulin-treated
1.5
6.4
215
1523
C10AA04
ATC
fluvastatin; oral
2.0
6.4
63
317
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.8
6.4
101
594
D07AC01
ATC
betamethasone; topical
1.4
6.4
358
2795
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.3
6.4
48
217
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
2.1
6.4
59
290
T90
ICPC
Diabetes non-insulin dependent
1.5
6.4
188
1296
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.6
6.3
136
869
K03.80
ICD-10 Finland
Irradiated enamel
2.0
6.3
70
367
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.3
6.3
44
192
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.0
6.3
66
339
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.5
6.3
260
1918
E03.89
ICD-10 Finland
Other specified hypothyroidism
2.4
6.3
43
186
00919
ICD-8 Finland
Diarrhoeal disease, Diarrhoea
11.1
6.3
11
10
UJF02
NOMESCO Finland
Peroral enteroscopy
11.1
6.3
11
10
5621A
ICD-9 Finland
Diverticula of intestine, Colon[DIVERTICULOSIS COLI]
9.3
6.3
12
13
M94.0
ICD-10 Finland
Chondrocostal junction syndrome [Tietze]
2.9
6.3
29
103
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.7
6.3
110
666
ZXA00
NOMESCO Finland
Right side
1.5
6.3
237
1719
Z3229
NOMESCO Finland
Other healthcare associate professional
1.8
6.3
85
477
X14
ICPC
Vaginal discharge
2.7
6.3
33
126
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
6.3
6
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.7
6.3
103
613
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.7
6.2
126
793
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.8
6.2
91
524
L07
ICPC
Jaw symptom/complaint
3.4
6.2
21
62
X72
ICPC
Genital candidiasis female
3.4
6.2
21
62
K29.7
ICD-10 Finland
Gastritis, unspecified
2.5
6.2
37
151
L20
ICPC
Joint symptom/complaint NOS
2.3
6.1
45
201
SFA40
NOMESCO Finland
Restoration involving the entire crown of the tooth
1.5
6.1
211
1501
WVA30, ,
SPAT
2.0
6.1
64
329
A10AC01
ATC
insulin (human); parenteral
1.9
6.1
73
393
L60.0
ICD-10 Finland
Ingrowing nail
2.1
6.1
57
281
N30.9
ICD-10 Finland
Cystitis, unspecified
1.9
6.1
75
408
J01CA04
ATC
amoxicillin; systemic
1.4
6.1
916
8364
A09AA02
ATC
multienzymes (lipase, protease etc.); oral
3.1
6.1
25
83
294
Kela drug reimbursment
Alirocumab and evolocumab for the treatment of hypercholesterolaemia and dyslipidaemia
12.6
6.1
10
8
D48
ICPC
Digestive, Clarification/discussion RFE/demand
12.6
6.1
10
8
UJF92
NOMESCO Finland
Capsular endoscopy
2.9
6.1
27
94
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
2.9
6.1
27
94
N06AX03
ATC
mianserin; oral
2.1
6.1
52
248
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.7
6.1
121
759
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.8
6.0
97
573
J01MA01
ATC
ofloxacin; systemic
1.9
6.0
77
424
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
1.7
6.0
121
760
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
1.8
6.0
93
543
S22
ICPC
Nail symptom/complaint
1.9
6.0
72
388
F51.0
ICD-10 Finland
Nonorganic insomnia
1.5
6.0
195
1370
F41.09
ICD-10 Finland
UNS Panic Syndrome
2.4
6.0
39
165
A10AE04
ATC
insulin glargine; parenteral
1.9
6.0
78
432

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
346
1433
3.01
59.23
2.6
2.6
94.57
114.10
ug/g
0.65
285
1133
482
2606
2.45
46.43
1.6
1.4
1.23
1.75
u/ml
0.61
106
700
422
2233
2.39
41.73
1.7
1.5
2.18
2.29
g/l
0.66
220
1387
538
3229
2.24
38.79
6.9
6.4
—
—
—
0
0
227
921
2.82
38.72
1.3
1.2
—
—
—
0
0
616
3951
2.19
37.06
7.7
5.7
1.22
1.22
mmol/l
0.01
574
3635
102
264
4.14
35.60
1.4
1.4
282.57
300.30
ug/g
0.34
53
153
657
4472
2.07
32.07
8.4
6.1
1.22
1.22
mmol/l
0.19
585
3858
654
4450
2.07
31.88
3.2
2.4
77.68
76.71
nmol/l
0.36
607
4063
730
5178
2.10
31.70
8.0
6.5
0.19
0.19
e9/l
0.02
610
4571
265
1268
2.41
31.66
1.3
1.2
—
—
—
0
0
592
3913
2.04
30.93
5.2
4.5
36.64
36.27
g/l
0.94
556
3664
152
558
2.98
30.79
1.2
1.1
—
1.03
—
0
6
708
5021
2.04
30.05
7.7
6.2
0.04
0.04
e9/l
0.42
580
4365
706
5013
2.04
29.72
7.7
6.2
0.57
0.56
e9/l
0.51
582
4359
681
4808
2.00
28.72
5.9
6.1
10.31
11.14
umol/l
1.59
653
4574
667
4676
2.00
28.70
7.6
6.2
56.30
56.40
%
0.08
635
4480
910
7168
2.23
28.10
9.4
7.4
76.72
78.66
u/l
0.87
875
6790
659
4629
1.97
27.87
7.8
6.4
8.54
8.66
%
0.56
621
4354
712
5138
1.99
27.81
7.7
6.3
1.95
1.96
e9/l
0.09
603
4589
659
4632
1.97
27.78
7.7
6.3
2.74
2.88
%
0.95
622
4351
658
4627
1.97
27.65
7.8
6.4
0.67
0.69
%
0.49
619
4337
670
4752
1.96
27.32
7.7
6.3
29.12
28.91
%
0.19
639
4523
583
3973
1.93
26.48
2.6
2.0
98.57
97.80
pmol/l
0.16
329
2093
264
1380
2.18
24.97
3.5
2.9
1.96
2.84
e6/l
0.83
99
657
373
2229
1.99
24.53
4.7
4.0
91.55
92.29
%
0.21
366
2173
746
5598
1.92
24.46
10.7
9.2
4.13
3.97
e9/l
0.92
627
4909
110
382
3.08
24.42
1.8
1.7
—
—
—
0
0
412
2564
1.94
23.95
3.9
3.5
7.40
7.40
ph
0.11
254
1844
513
3474
1.85
22.63
5.0
3.6
57.76
105.22
e6/l
0.92
318
2377
815
6404
1.91
21.94
6.1
4.3
3524.21
2877.96
e6/l
0.10
14
82
207
1035
2.22
21.61
1.5
1.4
—
—
—
0
0
275
1536
2.03
21.48
3.4
2.7
0.55
1.10
e6/l
5.09
107
813
259
1441
2.03
20.33
2.8
2.2
14.18
13.50
umol/l
0.56
240
1353
583
4198
1.78
20.23
4.1
3.2
6.17
6.23
ph
0.71
267
2385
389
2483
1.85
20.21
2.8
2.2
2.65
2.83
mg/l
0.86
338
2134
226
1201
2.09
20.08
2.9
2.3
22.64
23.02
%
0.13
207
1123
241
1323
2.04
19.56
2.9
2.2
2.43
2.36
g/l
1.01
218
1224
473
3235
1.78
19.34
3.1
3.2
2.36
2.36
mmol/l
0.22
420
2959
436
2915
1.79
19.24
2.9
2.3
53.31
63.03
u/l
2.86
410
2699
180
889
2.21
19.23
2.7
2.4
36.63
91.30
u/l
0.49
153
745
202
1055
2.11
18.69
2.4
2.8
5.82
6.97
umol/l
0.81
168
917
238
1322
2.01
18.61
3.9
3.7
0.82
0.82
mmol/l
0.27
224
1254
432
2925
1.76
17.97
3.8
3.0
27.64
90.05
e6/l
1.75
300
2238
198
1042
2.08
17.91
5.1
5.3
1.04
1.05
mmol/l
0.36
181
961
385
2524
1.78
17.88
3.7
3.0
0.23
0.39
e6/l
1.89
249
1851
355
2279
1.80
17.66
4.4
4.0
—
—
—
0
0
145
687
2.27
17.05
1.3
1.2
—
—
—
0
0
383
2578
1.72
15.84
2.4
2.0
156.40
237.42
u/l
1.21
363
2454
650
5035
1.66
15.63
3.8
3.0
92.91
98.06
ug/l
0.39
613
4740
675
5281
1.66
15.60
4.5
3.6
0.00
1.34
estimate
0.50
114
1125
382
2582
1.71
15.49
1.8
1.6
20.43
20.38
nmol/l
0.03
333
2189
242
1433
1.87
15.38
1.5
1.4
493.33
529.38
titre
0.17
48
290
678
5325
1.65
15.30
4.5
3.6
0.07
0.28
estimate
0.34
109
1080
678
5330
1.65
15.20
6.4
4.5
6.52
6.46
mmol/l
0.29
646
4973
667
5223
1.65
15.18
4.5
3.6
0.00
0.00
estimate
0.50
112
1103
415
2886
1.68
15.04
3.6
2.9
—
—
—
0
0
148
743
2.14
15.02
13.2
9.0
95.39
95.71
%
0.23
139
723
123
578
2.26
14.70
4.1
3.2
4.48
4.58
pmol/l
0.53
102
515
237
1413
1.85
14.68
1.9
1.7
1096.81
1152.68
nmol/l
0.46
182
1078
346
2306
1.71
14.62
3.2
3.0
1723.94
1022.92
ng/l
1.12
294
1916
447
3193
1.65
14.47
3.5
3.1
30.29
31.21
u/l
0.25
424
3023
915
7832
1.78
14.45
5.9
4.3
14.85
14.63
pmol/l
2.16
879
7252
325
2137
1.72
14.39
1.9
1.8
1.37
1.13
mg/l
0.52
242
1604
253
1553
1.80
14.20
4.3
3.3
102.55
546.35
ng/l
3.49
177
1053
138
691
2.13
14.08
14.1
9.2
119.98
120.96
g/l
0.23
131
677
75
286
2.73
14.01
1.2
1.2
—
—
—
0
0
158
835
2.03
13.96
12.6
8.5
0.71
1.02
mmol/l
0.39
130
678
164
893
1.97
13.29
2.6
3.0
1.65
1.73
%
0.60
142
810
1020
9096
1.97
13.24
7.5
5.1
1.76
1.86
mu/l
2.28
979
8509
509
3813
1.59
13.23
15.1
11.5
1.22
1.19
inr
0.44
404
3185
424
3048
1.61
13.05
2.6
2.2
—
—
—
0
0
338
2314
1.65
12.58
2.5
2.2
—
—
—
0
0
325
2222
1.64
12.08
2.7
2.5
324.57
327.05
umol/l
0.18
287
1968
154
847
1.94
12.08
12.7
8.4
5.04
5.14
kpa
0.75
147
814
154
847
1.94
12.08
13.0
8.5
7.43
7.42
ph
0.87
64
484
154
848
1.94
12.04
12.7
8.4
12.06
12.67
kpa
0.79
147
815
272
1780
1.69
11.96
3.1
2.7
2.44
2.44
mmol/l
0.51
234
1601
159
887
1.92
11.96
2.4
2.1
380.45
372.01
nmol/l
0.19
144
832
180
1056
1.83
11.55
11.8
6.6
104.63
104.67
mmol/l
0.04
180
1056
1059
9670
2.04
11.30
21.4
13.0
21.66
22.37
mg/l
0.31
917
7774
151
846
1.90
11.18
2.8
2.4
0.23
0.21
g/l
1.54
141
798
503
3865
1.53
11.08
2.4
2.0
—
—
—
0
0
436
3259
1.54
10.84
4.6
3.1
28.02
61.18
ng/l
0.79
267
2060
788
6714
1.54
10.32
4.0
3.1
42.23
41.89
u/l
0.05
758
6381
106
543
2.05
10.14
1.5
1.3
—
—
—
0
0
128
701
1.93
10.13
15.2
8.9
—
—
—
0
0
65
273
2.46
10.03
1.4
1.3
—
—
—
0
0
58
235
2.54
9.65
2.6
2.9
4.22
3.25
index
0.28
27
118
281
1949
1.58
9.53
1.5
1.3
30.62
30.67
iu/ml
0.00
61
573
32
94
3.47
9.37
1.7
1.4
0.19
0.18
nmol/l
0.27
25
69
185
1160
1.71
9.35
1.6
1.4
—
—
—
0
0
109
585
1.95
9.15
4.4
3.5
7.42
7.41
ph
0.55
89
489
115
642
1.88
8.58
3.6
3.3
79.01
79.21
ng/l
0.01
97
563
109
601
1.90
8.45
4.4
3.5
5.10
5.18
kpa
0.57
104
584
1047
9684
1.80
8.43
23.6
14.4
3.93
3.94
mmol/l
0.68
1030
9442
1045
9664
1.78
8.36
23.4
14.3
139.62
139.71
mmol/l
0.59
1029
9444
383
2907
1.47
8.35
5.9
5.8
—
—
—
0
0
201
1330
1.62
8.20
1.7
1.6
—
—
—
0
0
85
439
2.01
7.97
1.9
1.7
0.32
0.30
mg/l
0.11
37
188
83
433
1.99
7.58
2.5
2.3
—
—
—
0
0
255
1826
1.51
7.28
1.4
1.3
14.59
11.88
u/ml
0.12
79
723
184
1235
1.58
7.02
2.0
2.2
30.10
29.22
s
1.07
175
1197
37
141
2.68
7.02
2.2
1.9
5.13
4.98
mmol/24h
0.08
31
129
378
2943
1.42
6.94
3.8
3.2
7.70
7.72
mmol/l
0.03
342
2520
138
871
1.66
6.75
4.4
3.4
7.37
7.35
ph
1.45
105
620
168
1115
1.59
6.72
2.2
1.6
—
—
—
0
0
33
122
2.75
6.64
1.5
1.2
—
—
—
0
0
125
775
1.69
6.54
3.0
3.0
10.46
10.44
g/l
0.02
113
720
530
4406
1.37
6.47
10.9
10.2
0.00
0.00
e9/l
1.37
392
3621
89
502
1.84
6.46
1.1
1.1
—
—
—
0
0
46
203
2.32
6.45
2.9
2.3
133.28
130.36
g/l
0.47
36
165
72
380
1.95
6.39
1.6
1.6
9.63
8.86
u/ml
—
9
102
534
4471
1.36
6.11
3.0
2.7
—
—
estimate
—
0
0
79
437
1.87
6.10
4.6
3.6
—
—
—
0
0
137
889
1.61
6.01
1.5
1.5
—
—
—
0
0
100
598
1.74
5.98
2.0
1.9
1.36
1.44
g/l
0.15
93
553
183
1271
1.52
5.96
2.5
2.0
—
—
—
0
0
232
1692
1.46
5.95
3.1
2.6
516.34
537.30
mosm/kgh2o
0.68
198
1485
60
305
2.02
5.93
1.2
1.2
8.78
2.07
u/ml
—
6
26
56
281
2.04
5.74
1.6
1.7
9.64
10.50
g/l
0.86
49
254
54
269
2.06
5.65
1.3
1.3
—
867.27
—
0
11
266
2010
1.42
5.61
2.6
2.4
6.38
7.32
e6/l
0.43
234
1831
129
841
1.60
5.55
3.7
4.1
7.39
7.38
ph
0.70
68
480
468
3884
1.34
5.50
2.0
1.9
1.45
1.33
mmol/l
1.94
411
3325
77
439
1.81
5.43
1.6
1.9
4.45
7.09
iu/ml
0.48
13
97
1072
10170
1.67
5.42
14.6
10.6
26.17
25.46
u/l
0.48
1054
9897
108
678
1.65
5.41
2.7
2.9
73.53
68.53
e9/l
0.62
70
501
948
8766
1.44
5.41
7.0
5.2
39.06
38.00
mmol/mol
2.91
913
8229
37
161
2.34
5.39
2.1
3.0
27.68
35.68
umol/l
1.60
31
146
118
760
1.61
5.34
1.4
1.3
199.68
213.55
u/ml
0.08
110
707
26
96
2.75
5.29
2.0
1.4
—
—
nmol/l
—
0
0
58
306
1.94
5.20
1.4
1.2
—
—
—
0
0
28
111
2.56
4.98
1.6
1.6
49.39
24.50
ng/l
0.40
28
111
38
174
2.22
4.95
1.2
1.1
—
—
—
0
0
89
544
1.69
4.94
1.7
2.1
—
—
—
0
0
46
228
2.06
4.91
1.2
1.1
—
—
—
0
0
54
285
1.94
4.85
1.2
1.1
3.96
6.25
eliau/ml
—
8
44
53
278
1.95
4.85
1.3
1.2
121.67
97.33
titre
—
6
30
123
829
1.54
4.60
3.8
4.0
1.39
1.76
mmol/l
0.68
111
707
317
2542
1.34
4.53
4.1
3.3
45.78
36.80
mg/l
0.34
213
1594
322
2589
1.34
4.52
4.8
3.8
8.52
6.35
mg/mmol
0.44
206
1575
70
411
1.75
4.51
1.9
2.5
—
—
—
0
0
50
266
1.92
4.41
2.3
1.8
4.01
4.72
iu/l
0.25
24
99
254
1977
1.36
4.40
1.8
1.7
—
—
—
0
0
105
691
1.57
4.37
2.6
2.5
13.76
19.63
au/ml
—
10
74
297
2370
1.34
4.37
2.2
2.1
—
—
—
0
0
55
304
1.85
4.33
1.1
1.1
—
—
—
0
0
35
165
2.16
4.28
1.3
1.1
4.92
1.76
eliau/ml
1.12
19
75
170
1244
1.43
4.23
1.3
1.3
—
—
—
0
0
15
46
3.29
4.19
2.9
2.0
1.60
1.91
umol/l
0.89
15
40
14
41
3.44
4.19
1.1
4.0
0.29
0.20
e9/l
—
7
25
58
330
1.80
4.17
3.1
3.9
283.50
461.70
mg/l
0.46
22
148
968
9088
1.38
4.16
5.7
4.4
5.90
5.76
mmol/l
2.53
913
8371
41
208
2.01
4.16
1.7
2.9
1.30
1.80
ratio
1.21
18
115
1069
10231
1.54
4.04
25.4
16.0
74.00
72.54
umol/l
0.91
1056
10104
100
664
1.55
4.02
1.7
2.5
66.29
66.90
g/l
0.34
93
610
56
327
1.75
3.72
1.6
2.8
20.20
20.55
s
0.36
51
297
66
404
1.67
3.71
1.2
1.2
—
—
—
0
0
17
61
2.81
3.70
1.8
2.4
—
—
—
0
0
102
694
1.51
3.68
2.6
2.2
12.61
12.69
nmol/l
0.03
94
641
166
1240
1.39
3.67
4.1
3.0
3.98
4.91
e9/l
1.64
137
1091
135
972
1.44
3.67
1.6
1.5
—
—
—
0
0
48
270
1.81
3.62
2.4
2.6
—
—
—
0
0
38
198
1.95
3.61
2.6
3.6
61.48
62.95
%
0.15
33
193
114
799
1.47
3.57
2.5
2.5
6.10
6.15
ph
0.21
75
530
998
9471
1.37
3.55
6.2
4.9
2.72
2.79
mmol/l
1.72
953
8866
90
601
1.54
3.55
2.1
2.2
3.76
6.67
ug/l
2.79
74
530
988
9366
1.36
3.50
5.3
4.5
4.63
4.73
mmol/l
2.45
947
8815
41
224
1.86
3.40
1.7
1.8
196.46
213.63
pmol/l
0.38
35
215
29
140
2.10
3.40
2.1
2.4
123.51
75.26
ug/min
0.26
24
81
10
23
4.38
3.31
1.8
1.3
94.70
88.17
nmol/24h
—
10
23
53
316
1.71
3.30
1.4
1.7
1.15
1.19
g/l
0.52
46
301
106
745
1.47
3.29
3.1
3.6
4.72
4.61
kpa
0.20
101
722
51
302
1.72
3.26
1.4
1.7
0.24
0.24
g/l
0.09
43
289
66
420
1.61
3.22
2.4
1.9
—
—
—
0
0
45
259
1.77
3.18
2.8
2.4
—
—
—
0
0
65
414
1.60
3.16
1.4
1.2
0.29
1.16
u/ml
—
7
28
72
473
1.56
3.08
2.2
1.9
—
—
—
0
0
34
181
1.90
3.07
1.2
1.0
—
—
—
0
0
18
74
2.45
3.05
1.0
1.1
—
—
—
0
0
32
168
1.93
3.02
1.4
2.1
1.14
0.83
nmol/l
0.72
24
143
979
9317
1.32
2.98
5.3
4.4
1.45
1.50
mmol/l
3.44
933
8706
50
305
1.67
2.90
1.6
1.8
41.24
40.33
nmol/l
0.10
50
296
25
122
2.07
2.88
1.1
1.2
—
—
—
0
0
27
136
2.01
2.87
1.1
1.1
—
—
—
0
0
114
836
1.40
2.84
1.4
1.2
129.93
137.22
u/ml
0.08
39
333
17
71
2.41
2.81
1.6
1.5
6.85
5.89
ug/l
0.33
17
64
48
294
1.66
2.76
6.6
8.2
—
—
—
0
0
229
1872
1.28
2.73
1.9
1.7
44560008.57
37421823.13
pmol/l
0.06
193
1590
29
153
1.92
2.72
1.2
1.3
3.87
3.70
u/ml
0.05
15
66
12
41
2.95
2.62
1.2
1.2
131.54
148.66
nmol/l
0.49
12
41
19
87
2.20
2.58
2.7
2.5
17.31
12.35
index
0.82
13
55
17
75
2.29
2.51
1.6
1.7
14.48
11.78
umol/l
0.41
17
69
21
103
2.06
2.42
1.7
2.0
—
—
—
0
0
346
3951
0.82
2.39
3.0
2.7
—
—
—
0
0
66
453
1.48
2.37
1.3
1.3
261.81
234.74
miu/ml
0.23
33
229
77
548
1.43
2.30
2.1
1.9
—
—
—
0
0
277
2359
1.23
2.29
4.4
3.6
1.02
1.02
kg/l
0.25
178
1518
6
13
4.63
2.27
1.3
1.2
—
—
—
0
0
21
106
2.00
2.26
2.5
3.1
20.19
21.43
nmol/l
0.22
21
99
26
142
1.85
2.24
1.2
1.1
5337.35
155.19
iu/ml
—
6
32
1040
10057
1.32
2.24
17.7
11.6
—
—
—
0
0
30
172
1.76
2.22
1.2
1.8
0.80
0.83
g/l
0.07
23
143
17
80
2.14
2.19
1.3
1.1
95.29
117.38
pmol/l
1.32
17
80
121
937
1.33
2.18
2.0
1.9
0.22
0.02
estimate
0.65
23
201
13
55
2.38
2.12
2.9
2.3
0.54
0.78
index
0.83
13
55
1095
10684
1.41
2.10
31.7
20.0
258.70
255.79
e9/l
0.73
1074
10485
80
585
1.39
2.08
2.8
2.3
4679.15
6203.10
u/l
0.23
28
248
925
8842
1.22
2.08
4.5
3.8
1.32
1.23
mmol/l
2.91
870
8189
1095
10687
1.40
2.07
31.5
19.9
90.86
90.55
fl
1.37
1088
10575
1095
10690
1.40
2.03
31.5
19.9
30.22
30.16
pg
0.56
1088
10576
1095
10690
1.40
2.03
31.6
20.0
4.46
4.50
e12/l
2.74
1071
10461
1095
10690
1.40
2.03
33.0
20.3
39.96
40.30
%
1.63
1088
10572
12
50
2.41
2.03
3.2
2.0
25.50
28.59
umol/l
0.53
12
44
17
83
2.06
2.01
3.9
4.2
15.28
73.40
u/ml
—
8
24
9
32
2.83
2.00
1.0
1.3
4.78
0.76
u/ml
—
9
32
1095
10693
1.39
2.00
31.8
20.0
6.71
6.64
e9/l
0.53
1071
10458
36
225
1.62
1.98
2.3
1.6
6957.43
9870.68
e6/l
0.35
23
161
1095
10696
1.39
1.96
31.8
20.2
133.40
134.99
g/l
3.61
1088
10583
67
481
1.42
1.95
3.3
3.1
123.02
129.48
g/l
1.29
62
466
30
180
1.68
1.93
1.2
1.1
—
—
—
0
0
23
129
1.80
1.86
1.4
1.5
7.09
7.33
mmol/l
0.18
23
116
82
1078
0.74
1.86
1.4
1.3
—
—
—
0
0
63
452
1.42
1.85
6.6
8.0
24.59
24.52
mmol/l
0.05
58
434
79
590
1.36
1.84
2.0
1.9
—
—
—
0
0
35
224
1.58
1.78
1.3
1.8
3.11
10.05
e6/l
1.21
28
168
15
74
2.04
1.75
1.2
1.0
—
—
—
0
0
79
595
1.35
1.75
2.1
1.9
—
—
—
0
0
17
88
1.95
1.75
1.1
2.9
43.71
40.96
%
0.31
17
88
17
88
1.95
1.75
2.0
4.5
—
—
—
0
0
78
589
1.35
1.71
2.1
1.9
—
—
—
0
0
61
443
1.40
1.69
4.8
5.7
—
—
—
0
0
35
227
1.56
1.69
1.3
1.8
978.21
618.64
e6/l
0.18
29
178
10
40
2.51
1.66
1.6
1.1
—
—
—
0
0
26
157
1.67
1.66
3.7
3.5
—
—
—
0
0
16
83
1.94
1.65
1.1
1.1
0.27
0.61
u/ml
—
9
37
217
1865
1.20
1.63
5.2
4.9
1.53
2.87
ug/l
1.81
201
1682
33
214
1.56
1.61
1.3
1.8
—
—
—
0
0
6
20
3.01
1.58
3.0
2.3
—
—
—
0
0
18
99
1.83
1.58
3.7
2.3
0.80
0.88
%
—
9
66
44
306
1.46
1.56
2.7
1.9
4.00
2.42
ug/l
0.28
39
267
65
487
1.35
1.52
1.9
2.0
0.07
1.57
estimate
0.47
15
160
7
27
2.60
1.51
1.3
1.5
—
—
—
0
0
267
2356
1.17
1.49
5.7
4.6
—
—
—
0
0
83
648
1.30
1.47
1.4
1.5
25.15
23.82
iu/l
0.13
61
545
10
45
2.23
1.46
1.1
4.3
12862.30
65.62
mg/l
—
10
34
58
432
1.36
1.42
3.2
2.0
—
—
—
0
0
18
104
1.74
1.37
1.3
2.3
—
—
—
0
0
6
23
2.62
1.37
1.7
1.8
—
—
—
0
0
32
215
1.50
1.36
1.1
1.1
1.57
15.61
au/ml
—
6
59
325
2933
1.15
1.34
4.7
3.7
0.00
0.00
estimate
1.34
108
1054
13
69
1.89
1.29
1.2
1.1
—
—
—
0
0
28
410
0.68
1.25
1.1
1.1
0.58
0.64
ratio
—
5
42
30
432
0.69
1.24
1.2
1.1
1.47
1.55
g/l
1.14
30
432
99
813
1.24
1.20
3.7
4.4
4.04
25.42
ug/l
1.43
78
662
37
264
1.41
1.20
1.0
1.1
5.28
5.90
u/ml
0.07
22
164
56
428
1.32
1.20
1.1
1.1
—
—
—
0
0
74
591
1.27
1.15
2.2
1.9
—
—
—
0
0
5
20
2.51
1.15
1.0
1.3
4.78
5.27
nmol/l
—
5
20
16
95
1.69
1.14
3.9
2.0
31.81
31.42
pg
0.16
16
95
40
295
1.37
1.09
2.9
3.1
24.60
851.32
u/ml
1.30
32
249
32
228
1.41
1.06
1.3
1.3
256.10
230.46
u/ml
0.25
20
131
90
744
1.23
1.05
1.4
1.4
—
—
—
0
0
49
376
1.32
1.04
1.2
1.4
—
14.55
—
0
8
97
810
1.22
1.03
5.6
4.5
0.03
0.12
%
1.37
33
198
77
938
0.81
1.03
1.7
1.7
3.47
3.46
mmol/l
0.02
55
647
11
60
1.84
1.03
2.7
1.9
—
—
—
0
0
24
163
1.48
1.02
1.2
1.6
—
—
—
0
0
28
197
1.43
1.00
3.3
3.5
32.89
25.08
mg/l
0.30
15
134
100
843
1.20
0.98
5.5
4.4
0.39
0.97
%
2.83
36
231
14
84
1.67
0.98
1.1
1.1
0.15
1.32
u/ml
—
5
29
68
551
1.25
0.97
2.3
3.0
151.75
177.67
ng/l
0.29
63
502
48
373
1.30
0.95
1.4
1.5
9.03
8.75
u/l
0.05
34
288
17
109
1.57
0.94
2.8
2.4
—
—
—
0
0
129
1119
1.17
0.92
3.6
3.0
0.72
0.73
ug/l
0.04
82
660
33
439
0.74
0.90
1.3
1.1
0.85
0.89
g/l
0.49
33
439
53
422
1.27
0.89
1.5
1.3
—
—
—
0
0
72
595
1.22
0.88
2.2
3.1
25.16
84.98
u/ml
2.05
67
573
8
44
1.82
0.86
3.6
3.2
—
—
—
0
0
14
88
1.60
0.84
1.1
1.2
39.22
30.06
mg/l
0.33
14
66
14
88
1.60
0.84
1.0
1.2
—
—
—
0
0
6
31
1.94
0.84
1.5
1.6
—
—
—
0
0
83
701
1.20
0.82
2.3
2.0
0.10
0.39
e6/l
2.52
73
670
108
1243
0.86
0.82
1.9
1.9
3.52
3.44
ratio
0.25
85
950
31
232
1.35
0.81
1.2
1.1
—
—
—
0
0
31
232
1.35
0.81
1.2
1.1
—
—
—
0
0
13
81
1.61
0.81
1.7
1.3
2961.57
60956.00
e6/l
—
7
52
0
25
0.00
0.79
0.0
1.2
—
9.12
—
0
9
8
48
1.67
0.79
3.6
3.1
—
—
—
0
0
12
74
1.63
0.78
1.2
1.1
—
—
—
0
0
14
90
1.56
0.78
1.1
1.3
0.78
2.95
u/ml
—
9
46
96
828
1.17
0.76
5.6
4.7
0.00
0.19
%
2.24
30
188
10
59
1.70
0.76
2.6
2.8
651.10
908.14
u/ml
—
10
59
94
813
1.17
0.73
5.5
4.2
0.35
0.60
%
0.85
34
221
5
25
2.00
0.72
1.6
2.4
14.30
16.49
umol/l
—
5
25
5
25
2.00
0.72
2.0
1.2
—
—
—
0
0
10
60
1.67
0.72
1.3
1.2
—
—
—
0
0
26
194
1.35
0.71
1.6
2.5
3.31
6.58
umol/l
1.91
20
144
20
143
1.41
0.70
2.3
4.6
1.97
2.38
mmol/l
0.44
15
95
33
257
1.29
0.69
1.0
1.1
0.57
1.62
u/ml
1.01
17
133
42
339
1.25
0.67
1.1
1.2
—
—
—
0
0
5
28
1.79
0.66
1.0
1.1
27.40
28.14
s
—
5
28
12
78
1.54
0.65
1.2
1.1
—
—
—
0
0
11
70
1.58
0.65
1.1
1.3
—
—
—
0
0
38
305
1.25
0.64
1.1
1.1
2.11
3.53
u/ml
0.33
22
177
16
112
1.43
0.63
5.4
2.7
—
—
—
0
0
313
2940
1.09
0.63
3.7
3.0
0.00
0.04
estimate
0.93
87
891
12
79
1.52
0.62
1.1
1.0
—
—
—
0
0
5
30
1.67
0.61
1.2
1.5
117.40
138.66
mmol/24h
—
5
30
423
4028
1.08
0.60
4.6
3.5
0.00
0.06
estimate
1.57
87
933
11
72
1.53
0.59
1.5
1.3
0.82
1.22
promille
0.57
11
54
16
115
1.40
0.56
2.5
2.2
—
—
—
0
0
6
36
1.67
0.56
1.8
1.3
—
—
—
0
0
15
107
1.41
0.55
1.1
1.1
23.68
14.73
u/ml
—
6
49
8
125
0.64
0.54
1.4
1.3
—
—
—
0
0
20
151
1.33
0.54
1.7
3.7
—
—
—
0
0
9
63
1.43
0.52
1.7
1.6
4.03
3.17
mg/l
—
9
58
9
65
1.39
0.50
1.2
1.7
—
—
—
0
0
6
41
1.47
0.50
1.0
1.1
—
—
—
0
0
12
84
1.43
0.49
1.1
1.1
225.33
210.08
mg/l
0.11
12
73
18
136
1.33
0.49
1.2
1.5
—
—
—
0
0
18
136
1.33
0.49
1.2
1.5
—
—
—
0
0
18
136
1.33
0.49
1.2
1.5
—
—
—
0
0
18
136
1.33
0.49
1.2
1.5
—
—
—
0
0
5
32
1.56
0.42
1.0
1.4
—
—
—
0
0
17
131
1.30
0.42
1.6
1.5
—
—
—
0
0
8
58
1.38
0.41
1.1
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
5.5
—
7.53
—
0
15
0
15
0.00
0.41
0.0
1.1
—
0.02
—
0
15
32
268
1.20
0.41
1.1
1.1
2.68
1.78
u/ml
0.22
18
151
11
79
1.40
0.40
4.9
2.2
1.18
1.19
mmol/l
0.14
11
79
0
17
0.00
0.40
0.0
1.4
—
67.94
—
0
17
27
325
0.83
0.40
1.3
1.5
—
—
—
0
0
9
66
1.37
0.38
1.2
1.1
—
—
—
0
0
5
36
1.39
0.38
1.6
3.7
15.56
15.60
%
—
5
36
5
77
0.65
0.35
2.8
1.7
—
—
—
0
0
14
108
1.30
0.35
1.4
1.9
—
—
—
0
0
76
690
1.11
0.35
4.5
3.4
1.23
1.23
mmol/l
0.17
63
579
24
199
1.21
0.35
1.0
1.1
1.07
5.20
u/ml
—
9
97
28
330
0.84
0.35
1.3
1.6
—
—
—
0
0
11
83
1.33
0.32
4.9
2.2
107.73
105.77
mmol/l
0.85
11
83
11
83
1.33
0.32
4.9
2.2
4.09
3.98
mmol/l
0.34
11
83
11
83
1.33
0.32
1.2
1.5
—
—
—
0
0
54
598
0.90
0.30
1.8
1.7
—
—
—
0
0
12
93
1.29
0.30
1.2
1.1
—
—
—
0
0
28
241
1.17
0.29
2.2
3.7
55.04
57.69
%
0.40
28
241
20
167
1.20
0.28
1.3
1.1
—
—
—
0
0
13
103
1.27
0.28
1.2
1.2
—
—
—
0
0
20
168
1.19
0.27
1.2
1.1
—
—
—
0
0
70
758
0.92
0.26
1.4
1.6
916.65
966.34
mu/l
0.19
61
648
5
41
1.22
0.22
8.8
1.4
—
—
—
0
0
22
191
1.15
0.22
1.0
1.1
0.11
0.35
u/ml
—
6
69
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
10.80
—
0
5
0
10
0.00
0.21
0.0
1.2
—
1.92
—
0
10
0
10
0.00
0.21
0.0
1.2
—
140.40
—
0
5
0
12
0.00
0.21
0.0
3.5
—
44.57
—
0
7
5
43
1.16
0.21
1.6
1.7
—
3165.71
—
0
7
0
13
0.00
0.21
0.0
1.2
—
47.14
—
0
7
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
0.16
—
0
7
0
14
0.00
0.20
0.0
3.0
—
292.14
—
0
14
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
25
221
1.13
0.20
1.0
1.1
6.46
3.52
u/ml
0.21
11
118
79
836
0.94
0.18
4.9
3.7
—
—
—
0
0
7
58
1.21
0.18
1.0
1.0
—
—
—
0
0
153
1475
1.04
0.17
1.8
1.8
—
—
—
0
0
5
66
0.76
0.17
1.2
1.3
63.60
77.29
umol/l
—
5
66
112
1168
0.95
0.16
1.7
1.8
—
—
—
0
0
13
151
0.86
0.15
3.2
1.7
—
2413.33
—
0
6
12
103
1.17
0.13
1.4
1.1
—
—
—
0
0
30
277
1.09
0.13
1.4
1.3
—
—
—
0
0
11
95
1.16
0.11
2.0
1.7
90.40
90.35
%
0.01
11
95
22
201
1.10
0.11
2.0
1.8
—
—
—
0
0
11
96
1.15
0.10
1.3
1.2
—
—
—
0
0
17
187
0.91
0.10
8.5
4.7
—
—
—
0
0
5
44
1.14
0.10
2.6
2.4
51.20
47.00
umol/l
—
5
39
5
46
1.09
0.09
1.0
2.0
0.00
0.00
estimate
—
5
46
6
56
1.07
0.08
1.0
1.3
159.00
179.43
pmol/l
—
6
56
5
65
0.77
0.08
1.4
1.2
—
—
—
0
0
5
65
0.77
0.08
1.2
1.4
—
—
—
0
0
23
215
1.07
0.07
1.5
1.4
—
—
—
0
0
146
1485
0.98
0.06
1.6
1.6
—
—
—
0
0
21
197
1.07
0.06
1.5
1.5
133.43
144.79
au/ml
—
7
50
305
3020
1.01
0.06
1.5
1.6
—
—
—
0
0
10
90
1.11
0.05
1.0
1.2
—
—
—
0
0
23
219
1.05
0.04
1.6
1.5
0.67
0.35
nmol/l
0.58
17
176
11
114
0.96
0.00
1.3
1.7
—
—
—
0
0
11
112
0.98
0.00
3.3
2.2
—
—
—
0
0
6
65
0.92
0.00
3.3
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
83
0.96
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
0.42
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
49
1.02
-0.00
1.0
1.1
505.02
171.34
iu/ml
—
5
49
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
0.33
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
1.01
—
0
5
0
6
0.00
-0.00
0.0
7.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
0.04
—
0
7
7
75
0.93
-0.00
2.7
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
283.50
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
299.40
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
78.04
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_LACTONAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_LACTONAS 1.268 [1.11, 1.45] < 0.001
Birth year 0.994 [0.99, 1.0] 0.206

During the follow-up period (1.1.1998 — 31.12.2019), 473 out of 3734 females with E4_LACTONAS died.

Males

Parameter HR [95% CI] p-value
E4_LACTONAS 1.319 [1.13, 1.53] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 261 out of 2534 males with E4_LACTONAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_LACTONAS.

N-year risk Females Males
1 0.096% 0.259%
5 0.704% 1.519%
10 1.844% 3.612%
15 3.403% 6.835%
20 6.048% 11.223%

Relationships between endpoints

↥

Index endpoint: E4_LACTONAS – Lactose intolerance, other/unspecified

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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