Female pelvic inflammatory disorders in diseases classified elsewhere

N14_FEMPELINFINOTH

Pelvic Inflammatory Disease: Pelvic inflammatory disease (PID) is an acute or chronic inflammation in the pelvic cavity. It is most commonly caused by sexually transmitted diseases, including chlamydia and gonorrhea that have ascended into the uterus, fallopian tubes, or ovaries as a result of intercourse or childbirth, or of surgical procedures, including insertion of IUDs or abortion. PID may be either symptomatic or asymptomatic. It may cause infertility and it may raise the risk of ectopic pregnancy. PID is a disease associated with HIV infection.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

only females

313377

2. Check conditions

None

313377

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N74*
  • Cause of death: ICD-10 N74*

2 out of 7 registries used, show all original rules.

147

4. Check minimum number of events

None

147

5. Include endpoints

None

147

6. Filter based on genotype QC (FinnGen only)

138

Control definitions (FinnGen only)

Control exclude
N14_FEMALEGENINF

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1114 1114 -
Only index persons 1099 1099 -
Unadjusted period prevalence (%)
Whole population 0.03 0.03 -
Only index persons 0.04 0.04 -
Median age at first event (years)
Whole population - 23.59 -
Only index persons - 23.53 -

-FinnGen-

Key figures

All Female Male
Number of individuals 138 138 -
Unadjusted period prevalence (%) 0.05 0.05 -
Median age at first event (years) 24.91 24.91 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
143
Matched controls
1430
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N74.4*A56.1
ICD-10 Finland
Female chlamydial pelvic inflammatory disease
+∞
149.4
116
*
N73.9
ICD-10 Finland
Female pelvic inflammatory disease, unspecified
45.7
29.1
35
10
P01AB01
ATC
metronidazole; oral, rectal
6.1
23.0
104
436
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
41.1
22.0
27
8
O04.9
ICD-10 Finland
Medical abortion, complete or unspecified, without complication
5.2
20.6
61
178
A56.1
ICD-10 Finland
Chlamydial infection of pelviperitoneum and other genitourinary organs
+∞
20.3
19
*
N70.0
ICD-10 Finland
Acute salpingitis and oophoritis
178.7
15.8
16
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
4.1
15.7
83
360
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
4.3
15.5
96
464
N70.1
ICD-10 Finland
Chronic salpingitis and oophoritis
+∞
11.6
11
*
N06AB05
ATC
paroxetine; oral
5.6
11.2
23
47
N74.4
ICD-10 Finland
Female chlamydial pelvic inflammatory disease
+∞
10.5
10
*
N71.9
ICD-10 Finland
Inflammatory disease of uterus, unspecified
25.6
10.5
14
6
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
3.5
10.2
46
172
N02AX02
ATC
tramadol; systemic, rectal
3.1
10.0
65
301
M77.1
ICD-10 Finland
Lateral epicondylitis
4.4
9.3
26
69
J01AA02
ATC
doxycycline; systemic
4.0
8.9
121
832
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
3.3
8.9
43
166
N76.0
ICD-10 Finland
Acute vaginitis
3.7
8.6
32
104
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
3.2
8.6
43
169
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
3.5
8.2
33
113
EBA05
NOMESCO Finland
Complicated extraction of tooth
3.0
8.2
49
213
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.8
8.2
89
529
N05AH04
ATC
quetiapine; oral
3.0
8.1
49
214
TLC00
NOMESCO Finland
Insertion of intrauterine device
3.4
8.0
33
115
R51.80
ICD-10 Finland
Headache
2.8
7.5
49
223
D73
ICPC
Gastroenteritis presumed infection
4.2
7.4
21
56
N73.6
ICD-10 Finland
Female pelvic peritoneal adhesions
+∞
7.3
7
*
M79.6
ICD-10 Finland
Pain in limb
2.6
7.3
82
486
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
3.2
7.1
33
123
R10.0
ICD-10 Finland
Acute abdomen
9.0
7.0
14
17
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.6
7.0
25
79
LCA06
NOMESCO Finland
Biopsy of endometrium
3.2
6.8
31
114
L29
ICD-10 Finland
Pruritus
23.8
6.8
9
*
TLC02
NOMESCO Finland
Simple extraction of IUD
4.1
6.7
20
55
Z72.0
ICD-10 Finland
Tobacco use
9.4
6.7
13
15
O60
ICD-10 Finland
Preterm labour and delivery
4.3
6.7
18
46
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.8
6.6
39
167
N05CF01
ATC
zopiclone; oral
2.7
6.5
45
208
LCH11
NOMESCO Finland
Pharmacologic abortion
3.4
6.5
26
88
P29
ICPC
Psychological sympt/compl other
3.0
6.3
31
119
N70.9
ICD-10 Finland
Salpingitis and oophoritis, unspecified
+∞
6.3
6
*
SPAT1240
SPAT
Therapeutic discussion
2.8
6.3
38
164

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
60
291
2.83
8.21
2.3
2.2
47.51
59.29
u/l
1.54
53
278
85
513
2.62
7.29
3.3
5.3
7.87
9.41
umol/l
1.47
77
489
55
274
2.64
6.94
2.1
2.4
7.79
13.05
ng/l
1.84
19
94
64
368
2.34
5.71
2.9
2.1
—
—
—
0
0
44
216
2.50
5.56
3.3
2.3
2487.88
8073.94
u/l
1.05
18
101
96
684
2.23
4.79
4.5
3.1
0.00
0.00
estimate
-0.00
25
153
96
694
2.17
4.49
4.5
3.1
0.00
0.00
estimate
-0.00
24
151
37
185
2.35
4.40
2.2
3.2
—
—
—
0
0
78
531
2.03
4.17
3.9
2.9
0.10
0.01
estimate
0.43
21
130
95
696
2.09
4.13
4.5
3.2
0.00
0.00
estimate
-0.00
25
148
10
18
5.89
4.05
1.7
1.3
—
—
—
0
0
27
121
2.52
4.05
1.2
1.2
—
—
—
0
0
42
235
2.11
3.77
2.3
2.3
288.16
281.22
umol/l
0.22
37
218
64
418
1.96
3.74
3.5
2.3
0.05
0.01
estimate
0.38
20
127
80
564
1.95
3.73
3.9
2.9
6.29
6.28
ph
0.02
47
324
47
276
2.05
3.70
2.7
2.3
0.42
0.33
e6/l
0.13
32
194
29
149
2.19
3.19
1.2
1.2
—
—
—
0
0
15
58
2.77
2.98
1.3
1.8
0.38
0.22
mg/l
—
6
22
50
322
1.85
2.92
3.2
2.3
15.94
56.86
e6/l
1.21
38
231
20
91
2.39
2.90
1.5
1.8
—
—
—
0
0
56
376
1.80
2.84
4.6
3.2
0.00
0.00
estimate
-0.00
24
150
20
94
2.31
2.70
2.4
1.9
6.32
6.19
ph
0.21
11
60
27
144
2.08
2.69
1.8
1.8
—
—
—
0
0
82
623
1.74
2.67
3.4
3.9
6.23
6.03
mmol/l
0.39
71
538
126
1095
2.27
2.64
5.4
5.2
14.40
14.21
pmol/l
0.44
119
1051
39
240
1.86
2.59
2.7
2.3
—
—
—
0
0
23
120
2.09
2.43
4.6
2.7
—
—
—
0
0
101
827
1.75
2.40
5.5
6.5
69.62
71.01
u/l
0.18
95
787
5
8
6.43
2.39
1.0
1.4
—
—
—
0
0
59
421
1.68
2.33
4.5
2.9
7.77
36.73
e6/l
1.74
37
251
14
60
2.48
2.30
1.4
1.7
—
—
—
0
0
135
1239
2.60
2.27
6.4
5.9
1.51
1.65
mu/l
1.00
125
1201
31
186
1.85
2.21
3.0
2.1
572.67
562.18
mosm/kgh2o
0.06
26
158
25
140
1.95
2.18
1.3
1.1
—
—
—
0
0
6
15
4.13
2.06
1.3
1.5
—
—
—
0
0
51
363
1.63
1.98
1.4
1.3
1.88
2.02
g/l
0.39
27
240
56
414
1.58
1.84
1.3
1.3
0.72
2.11
u/ml
0.97
18
119
38
255
1.67
1.84
1.6
1.5
—
—
—
0
0
21
119
1.90
1.78
1.4
1.5
—
—
—
0
0
34
226
1.66
1.70
1.7
2.7
62.19
67.25
ug/g
0.07
24
174
105
912
1.57
1.57
6.1
3.8
—
—
—
0
0
21
125
1.80
1.54
1.5
1.5
—
—
—
0
0
21
126
1.78
1.50
1.5
1.5
—
—
—
0
0
5
16
3.20
1.45
1.2
1.1
—
—
—
0
0
50
381
1.48
1.37
3.2
4.6
1.23
1.22
mmol/l
1.01
43
365
5
17
3.01
1.37
1.8
1.9
—
—
—
0
0
43
320
1.49
1.32
3.6
3.0
1.02
1.02
kg/l
0.65
28
205
20
124
1.71
1.29
1.5
1.5
—
—
—
0
0
21
134
1.66
1.23
1.4
2.0
—
—
—
0
0
115
1041
1.53
1.21
4.7
4.0
36.25
36.21
mmol/mol
0.02
107
1011
15
87
1.81
1.20
1.1
1.1
—
46.00
—
0
5
41
309
1.46
1.17
1.7
1.8
0.50
0.94
mg/l
1.06
32
229
64
524
1.40
1.16
2.3
1.9
—
—
—
0
0
54
431
1.41
1.13
3.9
5.4
1.23
1.21
mmol/l
1.00
46
386
84
724
1.39
1.11
4.0
7.9
4.62
3.87
e9/l
2.02
74
638
134
1271
1.86
1.06
12.6
9.7
20.93
16.83
mg/l
0.77
120
988
121
1117
1.54
1.05
4.5
3.4
5.43
5.53
mmol/l
0.67
112
1063
15
91
1.72
1.05
1.3
1.1
—
—
—
0
0
52
417
1.39
1.05
1.7
2.0
—
—
—
0
0
46
362
1.40
1.03
3.9
5.5
—
—
—
0
0
40
307
1.42
1.03
1.5
1.4
9.33
30.69
iu/ml
2.11
11
81
19
124
1.61
1.03
1.1
1.5
—
—
—
0
0
68
575
1.35
0.97
4.1
5.4
0.66
0.65
%
0.05
61
543
16
102
1.64
0.95
1.4
1.5
—
—
—
0
0
68
577
1.34
0.94
4.0
5.3
2.94
2.75
%
0.24
60
550
126
1182
1.56
0.91
3.8
3.5
4.79
4.73
mmol/l
0.31
120
1153
68
580
1.33
0.90
4.1
5.3
7.48
7.96
%
1.11
61
554
6
31
1.98
0.85
1.5
1.4
—
—
—
0
0
76
663
1.31
0.84
2.5
2.6
—
—
estimate
—
0
0
8
46
1.78
0.84
1.4
1.4
—
—
—
0
0
8
48
1.71
0.80
1.4
1.6
—
—
—
0
0
13
83
1.62
0.78
3.6
5.8
105.46
105.93
mmol/l
0.18
13
83
18
125
1.50
0.77
1.4
1.5
—
—
—
0
0
9
53
1.74
0.77
3.2
5.6
5.27
5.34
mmol/l
—
9
53
125
1180
1.47
0.77
3.8
3.5
1.46
1.52
mmol/l
1.03
118
1146
12
76
1.63
0.74
1.1
1.2
—
—
—
0
0
10
60
1.72
0.74
3.5
2.0
0.04
0.19
e6/l
—
10
55
27
206
1.38
0.72
1.7
1.4
177.14
614.55
titre
—
7
33
22
162
1.42
0.71
1.5
1.5
—
—
—
0
0
69
604
1.28
0.71
4.2
5.2
30.49
30.09
%
0.12
61
584
125
1186
1.43
0.68
4.0
3.7
2.93
2.81
mmol/l
0.91
118
1154
5
28
1.81
0.67
1.4
1.3
—
—
—
0
0
7
44
1.62
0.66
6.4
2.0
0.21
0.24
g/l
—
7
44
37
302
1.30
0.65
3.0
3.0
6.74
8.04
mmol/l
1.15
32
277
72
641
1.25
0.62
4.0
5.6
0.53
0.51
e9/l
0.29
61
578
5
30
1.69
0.62
1.0
1.1
—
—
—
0
0
72
642
1.24
0.61
4.0
5.6
0.04
0.04
e9/l
0.39
62
574
42
353
1.27
0.59
2.3
1.9
2.79
2.52
mg/l
0.40
34
324
19
142
1.39
0.58
1.1
1.2
—
—
—
0
0
10
65
1.58
0.57
1.4
1.8
—
—
—
0
0
35
290
1.27
0.55
1.5
1.3
1.00
8.13
u/ml
—
10
126
19
144
1.37
0.54
2.2
2.0
2.48
2.51
g/l
0.08
13
134
34
282
1.27
0.53
1.5
1.4
18.82
21.57
nmol/l
0.52
27
260
17
128
1.37
0.50
1.2
1.3
—
—
—
0
0
18
137
1.36
0.50
1.7
1.5
—
—
—
0
0
13
93
1.44
0.50
4.8
4.3
0.95
1.02
mmol/l
0.51
13
84
7
47
1.51
0.48
2.7
1.9
1.02
1.02
ratio
—
7
42
7
47
1.51
0.48
1.4
1.1
—
—
—
0
0
7
47
1.51
0.48
1.4
1.1
—
—
—
0
0
73
664
1.20
0.48
4.1
5.5
2.12
1.96
e9/l
1.15
66
611
5
32
1.58
0.42
1.0
2.4
0.66
0.57
%
—
5
32
71
650
1.18
0.42
2.6
2.2
—
—
—
0
0
5
34
1.49
0.41
1.0
2.4
2.90
1.31
%
—
5
34
63
573
1.18
0.39
2.7
2.3
—
—
—
0
0
31
264
1.22
0.39
1.5
2.2
—
—
—
0
0
73
674
1.17
0.38
4.1
5.9
0.19
0.18
e9/l
0.30
66
612
17
206
0.80
0.31
1.2
1.3
—
—
—
0
0
7
57
1.24
0.29
1.1
2.2
0.90
1.32
mmol/l
—
7
43
64
594
1.14
0.29
4.0
5.1
56.92
56.45
%
0.12
59
576
44
399
1.15
0.28
3.7
3.9
36.77
37.72
g/l
0.58
38
383
13
158
0.81
0.25
1.2
1.5
—
—
—
0
0
5
37
1.36
0.24
1.4
1.1
—
—
—
0
0
11
88
1.27
0.23
1.8
1.2
—
34.66
—
0
5
7
93
0.74
0.23
1.1
1.1
—
—
—
0
0
29
259
1.15
0.22
2.6
3.2
7.40
7.40
ph
0.21
17
181
12
145
0.81
0.22
2.0
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
515.91
—
0
11
0
13
0.00
0.21
0.0
17.9
—
973.77
—
0
13
35
319
1.13
0.20
1.7
1.6
—
—
—
0
0
6
48
1.26
0.20
1.5
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
25.6
—
1916.07
—
0
14
48
449
1.10
0.18
1.6
1.8
91.31
95.30
pmol/l
0.24
26
265
14
162
0.85
0.17
1.3
1.6
—
—
—
0
0
60
570
1.09
0.16
8.4
8.4
0.00
0.00
e9/l
0.69
50
466
12
102
1.19
0.15
1.0
1.1
—
—
—
0
0
53
559
0.92
0.15
2.0
1.8
—
—
—
0
0
58
552
1.09
0.15
1.9
1.8
—
—
—
0
0
21
190
1.12
0.13
1.3
1.4
282.42
143.98
u/ml
—
6
86
54
517
1.07
0.11
1.9
1.8
—
—
—
0
0
5
44
1.14
0.10
3.6
7.5
—
—
—
0
0
5
47
1.07
0.09
1.0
1.3
—
—
—
0
0
47
489
0.94
0.09
1.7
1.7
1.64
1.30
mmol/l
0.45
38
450
8
75
1.07
0.07
1.6
1.5
0.40
0.45
nmol/l
—
8
64
9
86
1.05
0.07
2.0
1.0
1.53
1.58
g/l
—
9
86
9
87
1.04
0.07
2.1
1.1
0.99
0.84
g/l
—
9
87
22
213
1.04
0.01
4.9
4.2
4.08
11.52
mg/mmol
1.24
11
143
11
106
1.04
0.00
1.4
1.2
—
—
—
0
0
35
351
1.00
0.00
1.3
1.6
750.15
941.27
mu/l
1.21
29
295
36
359
1.00
0.00
3.2
3.8
—
—
—
0
0
35
345
1.02
0.00
3.5
5.1
—
—
—
0
0
14
145
0.96
0.00
2.2
2.2
3514.20
211.00
ng/l
—
5
52
14
135
1.04
0.00
1.7
1.3
—
—
—
0
0
21
212
0.99
0.00
4.0
3.6
35.58
66.36
mg/l
0.62
11
149
0
5
0.00
-0.00
0.0
2.8
—
10.21
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
27.43
—
0
7
6
68
0.88
-0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
0.02
—
0
5
0
9
0.00
-0.00
0.0
1.2
—
11.11
—
0
9
0
9
0.00
-0.00
0.0
1.2
—
77.78
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
9.24
—
0
5
0
8
0.00
-0.00
0.0
3.4
—
1.41
—
0
8
0
5
0.00
-0.00
0.0
1.8
—
54.80
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
82.96
—
0
9
0
8
0.00
-0.00
0.0
1.4
—
10.13
—
0
8
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
91.76
—
0
8
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.8
—
1.52
—
0
8
0
7
0.00
-0.00
0.0
2.3
—
1.64
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
7.01
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint N14_FEMPELINFINOTH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_FEMPELINFINOTH.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: N14_FEMPELINFINOTH – Female pelvic inflammatory disorders in diseases classified elsewhere

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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