No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
899 |
4. Check minimum number of eventsNone |
899 |
5. Include endpointsNone |
899 |
6. Filter based on genotype QC (FinnGen only) |
819 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Graves ophthalmopathy, strict
based on the number of shared cases.
Similar with more cases:
- Graves ophthalmopathy
- Disorders of lacrimal system and orbit in diseases classified elsewhere
- Disorders of orbit
- Thyrotoxicosis, other and/or unspecified
- Thyrotoxicosis
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3679 | 2975 | 690 |
| Only index persons | 3569 | 2906 | 663 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.09 | 0.02 |
| Only index persons | 0.09 | 0.11 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 51.38 | 51.28 | 51.88 |
| Only index persons | 51.22 | 51.20 | 51.31 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 819 | 671 | 148 |
| Unadjusted period prevalence (%) | 0.21 | 0.24 | 0.07 |
| Median age at first event (years) | 53.27 | 52.99 | 54.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 858
- Matched controls
- 8580
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
42.6
307.7
250
82
BAA60
NOMESCO Finland
Total thyroidectomy
46.0
307.7
317
108
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
477.7
307.7
746
118
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
86.2
307.7
459
113
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
307.7
850
*
H03BB01
ATC
carbimazole; oral
181.7
307.7
685
183
H03AA01
ATC
levothyroxine sodium; systemic
19.7
307.7
705
1628
104
Kela drug reimbursment
Thyroid insufficiency
14.4
301.0
338
370
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
51.1
247.6
145
34
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
38.2
211.0
133
41
H062, E050,
ICD-10 Finland
727.5
184.0
175
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
72.8
178.4
97
15
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
2051.4
173.0
162
*
H50.2
ICD-10 Finland
Vertical strabismus
50.8
156.4
91
20
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
193.5
142.4
145
9
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
7.3
142.3
687
3040
H53.2
ICD-10 Finland
Diplopia
13.1
142.3
146
132
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.2
122.4
564
2301
XCK00
NOMESCO Finland
Perimetry
7.4
93.8
152
244
C07AA05
ATC
propranolol; systemic
4.2
90.8
372
1322
H05.2
ICD-10 Finland
Exophthalmic conditions
198.3
87.0
89
5
T85
ICPC
Hyperthyroidism/thyrotoxicosis
29.0
84.3
57
21
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.2
81.9
203
486
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
12.5
65.2
66
57
E03.89
ICD-10 Finland
Other specified hypothyroidism
6.7
64.2
110
185
T86
ICPC
Hypothyroidism/myxoedema
5.6
55.4
114
228
ZX120
NOMESCO Finland
Intravenous
4.3
53.3
161
442
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.0
53.3
127
289
H50.0
ICD-10 Finland
Convergent concomitant strabismus
19.1
52.8
42
23
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
+∞
52.6
50
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
12.5
51.9
52
44
H02AB06
ATC
prednisolone; systemic
2.9
49.7
543
3182
CA1AD
NOMESCO Finland
Orbita CT
176.7
48.4
50
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.1
46.9
258
1040
H50.6
ICD-10 Finland
Mechanical strabismus
+∞
46.3
44
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.2
45.0
229
880
XCD10
NOMESCO Finland
Electrophysiological examination of eye
8.2
43.0
59
77
CEC00
NOMESCO Finland
Recession of extraocular muscle
62.0
40.7
47
8
ZXA10
NOMESCO Finland
Bilateral
2.9
38.5
237
1004
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
10.7
35.3
39
38
CAC44
NOMESCO Finland
Combined decompression of orbit
361.4
35.2
35
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
35.1
261
1211
H50.8
ICD-10 Finland
Other specified strabismus
128.7
35.0
37
*
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
125.1
33.9
36
*
H04.10
ICD-10 Finland
Dry eye syndrome
2.9
33.5
189
758
E03
ICD-10 Finland
Other hypothyroidism
3.7
32.9
116
350
CAC20
NOMESCO Finland
Lateral decompression of orbit
+∞
31.4
30
*
A02BC02
ATC
pantoprazole; systemic
2.6
30.2
678
5039
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
4.8
30.0
71
159
CBK00
NOMESCO Finland
Myotomy or resection of tarsal muscle or levator muscle of eyelid for correction of retraction
+∞
29.3
28
*
C07AB07
ATC
bisoprolol; oral
2.2
29.0
460
2927
L04AX03
ATC
methotrexate; systemic
3.0
28.6
144
539
WF099
NOMESCO Finland
Other radiotherapy
27.2
28.6
39
15
L04AA06
ATC
mycophenolic acid; systemic
7.5
28.2
41
57
H02AB07
ATC
prednisone; oral
2.7
27.4
175
743
CS494
NOMESCO Finland
Other visual field testing
5.6
25.7
50
94
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.5
24.5
62
146
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
6.9
24.4
38
57
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
38.8
24.1
30
8
A11CC03
ATC
alfacalcidol; systemic
6.2
23.6
41
69
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
123.3
22.7
24
*
2AB04, ,
NOMESCO Finland
46.4
22.5
27
6
H02.5
ICD-10 Finland
Other disorders affecting eyelid function
29.9
22.0
29
10
XCK10
NOMESCO Finland
Photography of fundus of eye
2.9
21.8
110
410
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
21.8
262
1457
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
20.8
371
2375
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
5.0
20.3
44
91
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
16.6
20.2
32
20
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
8.6
20.2
26
31
CEW99
NOMESCO Finland
Other operation on extraocular muscle
59.0
20.0
23
*
Z3231
NOMESCO Finland
Registered nurse
2.1
19.9
269
1554
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
19.9
352
2237
WX402
NOMESCO Finland
General anaesthesia
2.1
19.9
240
1329
CA1BM
NOMESCO Finland
Eye and orbita MRI examination with 3 Tesla magnet
+∞
19.9
19
*
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
+∞
19.9
19
*
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
29.7
19.7
26
9
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
3.2
19.7
82
273
E05.5
ICD-10 Finland
Thyroid crisis or storm
71.5
18.8
21
*
E05.89
ICD-10 Finland
Other thyrotoxicosis
39.3
18.6
23
6
N05CF01
ATC
zopiclone; oral
1.9
18.0
318
2005
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
27.4
17.9
24
9
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.6
17.5
111
464
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
14.2
17.4
29
21
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
3.8
17.3
54
149
WF002
NOMESCO Finland
Radical radiotherapy
3.6
16.6
56
163
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
14.9
15.9
26
18
H57.1
ICD-10 Finland
Ocular pain
3.2
15.4
63
207
CE2W4
NOMESCO Finland
Eye movement mapping
43.3
14.1
17
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
13.6
412
2990
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.1
13.6
151
800
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.7
13.2
73
284
Z3229
NOMESCO Finland
Other healthcare associate professional
2.6
13.0
80
329
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
4.8
12.9
29
62
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
14.6
12.3
20
14
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.7
12.2
293
1980
1XC02, ,
NOMESCO Finland
10.7
11.8
22
21
Z2221
NOMESCO Finland
Medical doctor
1.7
11.5
257
1697
H02AB09
ATC
hydrocortisone; systemic
3.9
11.3
33
87
S01KA02
ATC
hypromellose; ophthalmic
4.5
11.0
27
62
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
14.1
11.0
18
13
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
18.1
10.8
16
9
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
60.8
10.6
12
*
106
Kela drug reimbursment
Hypoparathyroidism
14.4
10.5
17
12
CBK99
NOMESCO Finland
Other operation for retraction of eyelid
111.3
10.4
11
*
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
3.8
10.2
31
84
F29
ICPC
Eye symptom/complaint other
2.0
10.2
116
617
S01GX01
ATC
cromoglicic acid; ophthalmic
1.7
10.2
213
1375
H03BA02
ATC
propylthiouracil; oral
22.0
9.4
13
6
WX002
NOMESCO Finland
Sedation and analgesia
1.8
9.3
169
1044
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
10.8
9.3
17
16
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
8.4
9.1
19
23
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
4.4
8.9
22
51
ZX090
NOMESCO Finland
Other technic of radiotherapy
3.2
8.7
34
109
ZXE00
NOMESCO Finland
One hour or less
1.6
8.7
337
2519
H50.52
ICD-10 Finland
Exophoria
4.5
8.7
21
48
H02.8
ICD-10 Finland
Other specified disorders of eyelid
11.7
8.6
15
13
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
3.6
8.6
28
80
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
6.5
8.5
21
33
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
8.5
194
1275
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
8.0
8.4
18
23
N07BA03
ATC
varenicline; oral
2.5
8.3
53
222
A11CC02
ATC
dihydrotachysterol; oral
14.6
8.2
13
9
H02.4
ICD-10 Finland
Ptosis of eyelid
3.0
8.2
36
124
CBB21
NOMESCO Finland
Correction of lax skin and resection of herniated fat in upper eyelid
7.6
8.2
18
24
WX892
NOMESCO Finland
Monitored bed care
2.3
8.1
64
295
CD2S4
NOMESCO Finland
Photography of eye
10.2
8.0
15
15
CA1BD
NOMESCO Finland
Extensive orbita CT
22.3
8.0
11
5
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
8.0
127
752
107
Kela drug reimbursment
Pernicious anaemia
4.2
7.8
20
48
H40.0
ICD-10 Finland
Glaucoma suspect
2.1
7.7
75
376
H02.3
ICD-10 Finland
Blepharochalasis
2.1
7.7
69
336
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
25.3
7.6
10
*
H50.1
ICD-10 Finland
Divergent concomitant strabismus
10.1
7.5
14
14
ZX050
NOMESCO Finland
Stereotactic radiotherapy
8.5
7.3
15
18
CAB00
NOMESCO Finland
Anterior orbitotomy with excision of lesion
+∞
7.3
7
*
E05.4
ICD-10 Finland
Thyrotoxicosis factitia
30.3
7.2
9
*
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
20.2
7.1
10
5
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
7.1
115
685
CB9S4
NOMESCO Finland
Photography of eyelids and eyebrows
12.1
7.1
12
10
E83.51
ICD-10 Finland
Hypocalcemia
7.1
7.0
16
23
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.1
7.0
63
307
ZXA00
NOMESCO Finland
Right side
1.6
7.0
214
1504
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.8
7.0
109
643
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.8
6.7
101
590
TCC40
NOMESCO Finland
Closure of lacrimal canaliculus with plug
12.4
6.6
11
9
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.4
6.5
45
196
ZXE40
NOMESCO Finland
More than seven and less than nine hours
3.3
6.4
23
70
XCW12
NOMESCO Finland
Assessment of colour vision
70.4
6.4
7
*
R4110
NOMESCO Finland
Physiotherapy
1.5
6.4
232
1687
ZXC95
NOMESCO Finland
Use of surgical navigator
3.8
6.4
19
51
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.0
6.3
72
384
H05.0
ICD-10 Finland
Acute inflammation of orbit
26.9
6.2
8
*
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
26.9
6.2
8
*
ZXE20
NOMESCO Finland
More than three and less than five hours
1.7
6.0
105
638
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
479
567
17.86
307.65
8.6
3.4
4.64
4.52
pmol/l
0.78
457
497
498
265
43.41
307.65
5.8
1.9
6.08
4.09
iu/l
2.11
359
105
223
694
3.99
62.76
1.5
1.2
191.12
146.62
u/ml
0.89
108
285
844
6377
20.83
55.49
17.4
4.8
15.93
14.64
pmol/l
40.73
821
5914
593
3919
2.66
38.30
8.1
6.7
1.21
1.22
mmol/l
1.70
520
3385
541
3514
2.46
34.75
6.9
5.9
1.21
1.22
mmol/l
1.60
516
3242
168
626
3.09
34.02
3.0
3.6
53.37
81.23
ng/l
9.19
153
552
626
4578
2.36
27.28
10.4
9.7
3.85
3.97
e9/l
0.77
546
4018
846
7300
12.36
27.10
19.2
5.9
1.64
1.88
mu/l
3.53
823
6815
431
2828
2.05
23.29
3.4
3.4
2.33
2.36
mmol/l
5.14
389
2575
534
3833
2.04
21.96
3.0
2.5
75.90
78.44
nmol/l
1.38
499
3488
727
6013
2.37
18.71
9.7
8.0
76.37
77.95
u/l
0.41
711
5704
160
820
2.17
15.85
2.5
2.1
367.47
378.65
nmol/l
0.34
149
763
704
5890
2.09
15.33
5.2
4.5
11.40
11.72
mm/h
0.26
670
5502
566
4474
1.78
13.88
4.8
4.5
6.38
6.57
mmol/l
1.67
542
4242
469
3540
1.72
13.32
11.8
11.0
0.00
0.00
e9/l
0.34
365
2911
34
92
3.81
11.22
4.4
5.5
38.98
45.21
u/ml
0.11
12
33
446
3430
1.63
10.92
4.3
4.5
35.98
36.06
g/l
0.12
418
3237
45
154
3.03
10.33
2.2
2.7
5.03
7.76
pmol/l
2.81
45
154
794
7257
2.26
9.33
6.8
6.1
38.69
38.83
mmol/mol
0.20
761
6832
828
7737
3.01
8.81
20.0
16.5
139.84
139.72
mmol/l
0.81
819
7583
828
7749
2.96
8.55
20.2
16.6
3.92
3.94
mmol/l
1.90
817
7580
254
1785
1.60
8.51
1.6
1.5
2.17
2.33
g/l
0.80
145
1103
177
1144
1.69
8.23
3.1
2.9
4.37
3.40
e6/l
0.34
81
515
813
7569
2.41
8.01
16.4
14.6
21.41
21.56
mg/l
0.05
676
6184
49
202
2.51
7.96
2.1
3.1
1.73
2.10
index
0.19
26
103
285
2084
1.55
7.95
3.1
3.0
0.22
0.41
e6/l
1.81
195
1514
188
1260
1.63
7.54
2.9
2.8
1.67
1.17
e6/l
0.39
93
632
281
2068
1.53
7.53
1.4
1.3
1.36
1.47
u/ml
0.08
69
564
192
1301
1.61
7.35
3.4
3.0
0.82
0.82
mmol/l
0.00
177
1234
796
7391
2.07
7.20
5.7
5.1
5.82
5.85
mmol/l
0.24
764
6853
52
235
2.29
6.93
1.2
1.2
48.72
55.20
u/ml
—
5
27
123
754
1.74
6.88
2.2
2.3
29.38
41.85
u/l
2.55
103
631
424
3446
1.46
6.74
2.3
2.1
103.99
97.95
pmol/l
1.61
217
1725
23
68
3.45
6.73
1.1
1.1
1.13
1.15
nmol/l
—
7
6
19
50
3.86
6.56
6.6
8.3
6.96
332.32
ug/l
0.53
14
35
264
1968
1.49
6.48
4.4
3.6
92.05
94.98
%
1.15
259
1920
199
1399
1.55
6.43
4.4
3.5
214.52
280.46
ng/l
0.16
156
1006
148
971
1.63
6.40
4.9
5.1
1.06
1.04
mmol/l
0.42
133
892
793
7423
1.90
5.94
16.8
14.0
83.83
82.78
ml/min/173m2
0.86
740
6845
839
8037
2.98
5.76
16.6
11.9
23.83
24.87
u/l
1.54
830
7830
218
1603
1.48
5.62
2.9
2.7
2.42
2.45
mmol/l
2.47
189
1448
610
5401
1.45
5.57
3.7
3.2
35.36
44.21
u/l
3.38
592
5105
307
2414
1.42
5.53
3.3
3.2
37.82
48.61
e6/l
0.27
217
1835
839
8061
2.84
5.25
22.7
18.7
71.03
71.71
umol/l
0.35
832
7971
247
1884
1.44
5.21
2.2
2.2
—
—
—
0
0
38
171
2.28
5.17
2.4
2.2
4.85
5.14
mmol/24h
0.26
32
153
490
4210
1.38
5.08
3.6
3.9
0.00
0.00
estimate
0.50
94
863
78
461
1.76
4.96
2.9
3.0
155.71
168.15
ng/l
0.13
69
428
493
4256
1.37
4.87
3.6
3.9
0.00
5.55
estimate
1.07
96
886
497
4298
1.37
4.85
3.7
3.9
0.00
0.02
estimate
1.46
93
827
132
902
1.55
4.77
2.2
2.4
6.10
6.60
umol/l
0.25
109
793
69
400
1.79
4.69
1.6
2.1
8.97
7.25
iu/ml
0.15
14
96
65
370
1.82
4.69
2.1
2.2
42.43
40.30
u/l
0.36
58
333
12
22
5.52
4.61
1.6
1.3
0.43
0.38
ug/l
—
7
16
101
659
1.60
4.45
2.2
3.1
10.16
10.47
g/l
0.29
92
616
49
268
1.88
4.04
1.1
2.1
0.66
0.93
g/l
0.15
44
242
250
1990
1.36
3.95
2.7
2.2
2.49
2.87
mg/l
2.45
220
1698
208
1616
1.38
3.80
1.4
1.3
8.15
10.77
u/ml
0.25
63
631
47
259
1.86
3.80
1.5
1.5
0.31
0.09
iu/ml
—
6
38
22
90
2.48
3.74
1.3
1.2
—
—
—
0
0
15
50
3.04
3.70
2.3
1.8
—
—
—
0
0
50
289
1.78
3.49
1.1
2.0
3.03
2.98
g/l
0.14
45
269
446
3936
1.28
3.15
3.9
3.1
92.21
104.88
ug/l
1.01
421
3701
398
3465
1.28
3.13
2.0
1.9
1.28
1.34
mmol/l
1.26
346
2952
14
50
2.83
3.09
1.1
1.3
35.61
28.81
umol/l
0.23
14
45
270
2245
1.30
3.03
1.6
1.7
21.04
21.01
nmol/l
0.01
236
1894
45
265
1.74
2.98
1.2
1.9
9.69
10.66
g/l
1.23
40
243
50
305
1.68
2.93
1.1
2.0
4.24
4.35
g/l
0.48
45
285
50
305
1.68
2.93
1.1
2.0
4.12
3.80
g/l
0.26
45
285
50
305
1.68
2.93
1.1
2.0
7.81
7.49
g/l
0.74
45
285
25
123
2.06
2.84
1.8
1.6
—
—
—
0
0
109
798
1.42
2.81
2.9
4.4
231.35
247.52
u/l
0.49
102
763
844
8255
2.37
2.77
30.8
22.7
261.64
258.14
e9/l
0.94
833
8117
465
4167
1.25
2.73
6.1
6.2
11.33
10.67
umol/l
0.46
450
3970
844
8258
2.35
2.71
30.7
22.7
4.51
4.46
e12/l
2.73
831
8095
215
1760
1.30
2.68
1.4
1.3
29.79
30.60
iu/ml
0.03
62
553
27
141
1.94
2.63
1.1
1.1
—
18.00
—
0
7
25
127
2.00
2.62
1.2
1.1
1.77
1.41
u/ml
0.82
13
39
224
1854
1.28
2.55
2.0
1.7
1.01
1.05
mg/l
0.07
170
1447
152
1197
1.33
2.50
1.7
1.7
1048.89
1199.01
nmol/l
1.41
113
886
18
363
0.49
2.48
4.8
3.4
51.13
48.57
%
0.15
18
355
204
1679
1.28
2.42
2.4
2.6
6.15
7.14
e6/l
0.39
176
1532
318
2758
1.24
2.42
3.5
3.0
28.53
29.75
u/l
0.38
302
2615
413
3685
1.23
2.41
2.6
2.6
—
—
estimate
—
0
0
85
616
1.42
2.34
1.6
2.9
66.11
67.46
g/l
0.92
76
578
61
414
1.51
2.34
1.5
1.7
—
—
—
0
0
281
2412
1.25
2.33
2.3
2.1
154.49
186.77
u/l
0.35
260
2291
76
540
1.45
2.33
1.6
1.9
—
—
—
0
0
158
1264
1.31
2.33
2.7
2.4
14.51
13.36
umol/l
1.15
150
1171
16
72
2.25
2.28
1.1
1.2
—
—
—
0
0
6
13
4.64
2.27
1.0
1.2
—
—
—
0
0
146
1161
1.31
2.25
2.6
2.4
2.42
2.36
g/l
0.63
136
1076
140
1108
1.31
2.23
1.9
2.2
165.45
108.30
ug/g
0.46
112
879
16
73
2.21
2.22
1.1
1.2
—
—
—
0
0
17
80
2.15
2.19
1.1
1.1
—
—
—
0
0
85
624
1.40
2.19
3.4
3.7
1.22
1.23
mmol/l
1.01
78
530
24
129
1.89
2.18
1.2
1.4
—
—
—
0
0
24
129
1.89
2.18
1.2
1.4
—
—
—
0
0
16
75
2.15
2.09
1.1
1.1
—
—
—
0
0
16
75
2.15
2.09
1.1
1.1
—
—
—
0
0
74
535
1.42
2.09
1.3
1.3
71.52
38.27
au/ml
—
6
43
6
15
4.02
2.04
4.2
2.1
260.67
105.00
u/l
—
6
15
115
902
1.32
1.96
1.9
1.8
—
—
—
0
0
101
782
1.33
1.89
8.2
7.5
1.16
1.12
mmol/l
0.03
81
660
62
445
1.42
1.84
1.0
1.1
—
—
—
0
0
38
247
1.56
1.82
1.3
1.4
255.87
301.03
ug/g
0.74
23
146
17
87
1.97
1.80
1.6
1.2
0.49
0.87
u/ml
—
10
40
368
3315
1.19
1.78
11.9
11.9
1.20
1.18
inr
0.33
315
2722
148
1216
1.26
1.78
2.0
1.9
—
—
—
0
0
12
54
2.24
1.74
1.6
1.7
46.58
107.01
ng/l
3.11
12
54
789
7663
1.37
1.73
5.0
5.1
4.79
4.79
mmol/l
0.04
745
7194
540
5045
1.19
1.69
3.2
3.2
—
—
—
0
0
37
244
1.54
1.68
1.2
1.3
—
—
—
0
0
24
142
1.71
1.66
1.5
1.5
—
—
—
0
0
17
90
1.91
1.66
1.3
1.2
—
—
—
0
0
10
42
2.40
1.62
2.0
3.0
0.90
0.79
index
—
10
42
22
128
1.74
1.61
1.0
1.0
2.17
1.98
eliau/ml
—
6
55
35
232
1.53
1.57
2.0
3.7
34.75
40.15
mg/l
0.40
26
200
22
130
1.71
1.54
1.3
1.1
2.62
4.89
u/ml
0.50
16
47
76
584
1.33
1.53
2.5
2.4
15.35
23.72
au/ml
—
6
58
11
51
2.17
1.51
1.2
1.1
—
—
—
0
0
106
858
1.27
1.46
2.0
1.9
—
—
—
0
0
15
80
1.89
1.45
1.6
1.7
—
—
—
0
0
45
320
1.43
1.45
1.6
1.7
—
—
—
0
0
51
686
0.73
1.41
1.8
1.8
3.59
3.50
mmol/l
0.18
37
484
70
539
1.33
1.40
1.3
1.4
25.94
29.30
iu/l
0.39
54
466
128
1066
1.24
1.39
2.9
2.4
23.13
22.72
%
0.14
119
995
59
445
1.35
1.36
1.5
1.8
—
—
—
0
0
34
232
1.48
1.36
2.0
3.7
32.65
59.44
mg/l
0.88
25
199
18
105
1.73
1.34
1.1
1.4
—
—
—
0
0
16
90
1.79
1.33
1.6
1.6
—
—
—
0
0
794
7756
1.32
1.33
6.0
5.8
2.84
2.80
mmol/l
0.61
750
7260
181
1569
1.19
1.31
1.6
1.6
—
—
—
0
0
8
35
2.30
1.27
1.4
1.8
72.63
51.32
ug/l
—
8
35
21
131
1.62
1.24
1.2
1.4
177.14
166.47
au/ml
—
7
35
30
205
1.48
1.21
1.5
3.5
1.15
4.09
ratio
0.97
14
117
20
125
1.61
1.18
1.9
2.8
—
2874.70
—
0
10
781
7630
1.26
1.17
5.0
5.0
1.51
1.54
mmol/l
0.96
735
7130
73
905
0.79
1.15
1.8
2.0
3.26
3.36
ratio
0.34
58
705
8
39
2.06
1.15
1.0
1.1
—
—
—
0
0
289
2633
1.15
1.12
3.1
3.3
6.98
7.26
mmol/l
0.50
251
2239
40
294
1.38
1.12
1.7
1.8
1.39
1.50
g/l
0.36
32
258
10
51
1.97
1.11
1.1
1.5
9.88
10.52
umol/l
—
10
45
33
236
1.41
1.08
1.2
1.1
—
—
—
0
0
33
236
1.41
1.08
1.2
1.1
—
—
—
0
0
200
1779
1.16
1.07
1.4
1.5
—
—
—
0
0
10
52
1.93
1.06
1.0
1.1
—
—
—
0
0
22
146
1.52
1.04
1.0
1.0
0.66
1.32
u/ml
0.45
14
63
32
232
1.39
0.99
1.2
1.2
—
—
—
0
0
5
23
2.18
0.98
1.0
1.2
—
—
—
0
0
0
29
0.00
0.98
0.0
1.1
—
110.50
—
0
22
0
31
0.00
0.96
0.0
1.1
—
0.28
—
0
26
73
599
1.24
0.95
2.8
3.1
0.73
0.76
ug/l
0.19
47
370
9
52
1.74
0.92
1.1
1.1
—
—
—
0
0
9
52
1.74
0.92
1.7
1.5
—
—
—
0
0
31
227
1.38
0.91
1.5
1.6
67.62
59.88
ug/l
0.26
26
189
6
29
2.08
0.89
1.0
1.2
—
—
—
0
0
65
533
1.24
0.87
1.5
1.6
—
—
—
0
0
42
326
1.30
0.86
1.6
1.6
16.35
11.32
u/ml
—
6
77
26
187
1.40
0.86
1.3
1.3
16.77
12.63
u/l
0.50
20
149
254
2333
1.13
0.85
3.4
3.3
0.01
0.02
estimate
0.28
84
707
13
80
1.63
0.85
2.8
3.7
—
—
—
0
0
10
57
1.76
0.84
1.3
1.4
—
22.00
—
0
8
11
178
0.61
0.83
1.4
1.6
—
—
—
0
0
234
2141
1.13
0.83
2.7
3.0
1352.98
864.69
ng/l
0.86
195
1794
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
23
165
1.40
0.78
4.9
2.5
0.35
0.37
iu/ml
—
8
89
18
123
1.47
0.78
1.1
1.1
0.25
1.87
—
5
24
29
217
1.35
0.77
3.0
2.7
—
—
—
0
0
7
38
1.85
0.73
1.6
1.6
—
—
—
0
0
123
1091
1.15
0.71
3.2
1.8
30.22
29.22
s
0.55
117
1057
18
126
1.44
0.70
1.1
1.1
0.50
3.20
u/ml
1.52
11
45
37
292
1.28
0.70
1.1
1.3
202.17
239.32
miu/ml
0.26
19
146
28
213
1.33
0.69
5.9
2.0
179.46
179.73
%
0.01
28
204
17
237
0.71
0.67
2.1
4.5
1.19
1.22
mmol/l
0.07
17
232
5
28
1.79
0.66
1.0
2.3
43.76
42.28
g/l
—
5
28
5
29
1.73
0.64
1.2
1.1
—
—
—
0
0
5
29
1.73
0.64
2.6
1.3
—
—
—
0
0
10
151
0.66
0.60
1.3
1.7
—
—
—
0
0
71
614
1.17
0.59
2.0
1.5
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
51
429
1.20
0.58
1.2
1.4
—
—
—
0
0
210
1951
1.10
0.57
2.5
2.5
313.47
321.66
umol/l
0.59
189
1727
77
878
0.86
0.57
7.2
6.6
—
—
—
0
0
6
37
1.63
0.55
1.5
2.3
—
—
—
0
0
27
213
1.28
0.54
1.4
1.5
—
—
—
0
0
27
214
1.27
0.53
1.4
1.5
1.12
1.20
ratio
0.16
13
141
27
214
1.27
0.53
1.4
1.5
1.14
0.99
ratio
0.77
13
141
27
214
1.27
0.53
1.4
1.5
1.00
1.11
ratio
0.26
13
141
9
63
1.43
0.52
1.1
1.2
—
—
—
0
0
9
63
1.43
0.52
1.1
1.2
—
—
—
0
0
31
252
1.24
0.50
1.4
1.5
—
—
—
0
0
7
47
1.49
0.47
1.6
1.2
20.00
9.06
mm/h
—
7
47
267
2531
1.08
0.47
2.8
2.4
53.60
61.21
u/l
1.54
252
2348
7
48
1.46
0.47
1.7
1.5
1.73
5.87
u/l
—
7
38
27
331
0.81
0.46
1.0
1.2
0.96
0.90
g/l
0.48
27
331
5
81
0.62
0.46
1.0
1.1
—
—
—
0
0
28
228
1.24
0.45
1.1
1.1
3.23
4.26
—
7
33
11
77
1.43
0.45
2.3
3.0
62.27
54.50
%
1.29
11
69
23
183
1.26
0.45
1.0
1.1
0.33
2.55
u/ml
2.26
12
91
5
31
1.62
0.43
1.2
1.1
47.24
37.07
u/ml
—
5
31
101
920
1.11
0.42
1.4
1.7
1.42
1.41
%
0.06
88
810
56
636
0.87
0.42
2.4
2.5
68.61
68.49
ml/min/173m2
0.01
23
270
10
138
0.72
0.40
2.4
1.8
50.90
44.69
nmol/l
—
10
132
87
789
1.11
0.40
3.8
4.3
21.19
22.26
%
0.32
36
369
5
34
1.47
0.40
1.0
1.0
—
—
—
0
0
28
232
1.21
0.40
4.1
1.7
96.43
95.23
%
0.11
28
223
263
2508
1.07
0.39
4.0
4.0
4.83
6.89
mg/mmol
0.78
145
1488
69
768
0.89
0.39
3.1
4.3
252.53
15.52
ug/l
0.48
55
617
0
19
0.00
0.39
0.0
3.5
—
10.38
—
0
19
0
19
0.00
0.39
0.0
3.5
—
4.79
—
0
19
75
676
1.12
0.39
3.0
3.1
1.98
2.00
mmol/l
0.02
58
585
48
547
0.87
0.39
2.3
2.4
6.77
5.80
ug/l
0.19
39
488
10
72
1.39
0.37
1.1
1.1
—
—
—
0
0
13
168
0.77
0.36
1.1
1.7
—
—
—
0
0
27
320
0.84
0.36
1.0
1.1
1.62
1.58
g/l
0.32
27
320
5
79
0.63
0.35
1.8
1.5
—
—
—
0
0
5
79
0.63
0.35
1.8
1.5
—
—
—
0
0
5
79
0.63
0.35
1.8
1.5
—
—
—
0
0
738
7291
1.09
0.35
4.2
4.2
1.23
1.26
mmol/l
0.76
683
6752
23
190
1.22
0.35
1.9
1.5
1736.33
12500.50
e6/l
2.21
18
132
17
211
0.80
0.35
1.1
1.3
—
—
—
0
0
6
44
1.37
0.34
1.0
1.4
—
—
—
0
0
6
45
1.34
0.34
2.3
2.2
—
—
—
0
0
26
219
1.19
0.33
1.7
1.7
—
—
—
0
0
29
247
1.18
0.33
1.3
1.3
—
—
—
0
0
6
46
1.31
0.33
1.3
1.1
—
—
—
0
0
6
46
1.31
0.33
1.2
1.2
—
—
—
0
0
38
332
1.15
0.32
1.3
1.6
0.25
0.37
mg/l
1.09
14
144
42
370
1.14
0.32
1.4
1.6
1144.87
998.95
mu/l
0.27
35
303
14
110
1.28
0.32
1.0
1.1
—
—
—
0
0
21
174
1.21
0.31
2.1
2.1
131.60
129.78
g/l
0.13
15
137
13
103
1.27
0.28
2.2
1.7
—
—
—
0
0
27
310
0.87
0.26
2.7
3.3
25.71
25.46
mmol/l
0.17
22
303
18
150
1.20
0.26
1.8
1.3
—
—
—
0
0
64
588
1.10
0.26
7.6
6.8
8.52
8.93
mmol/l
0.22
57
569
22
256
0.86
0.25
1.1
1.4
76.91
234.87
pmol/l
1.59
22
250
10
127
0.78
0.25
1.1
1.5
94.77
55.15
ug/l
—
10
127
330
3212
1.04
0.24
3.7
3.8
0.04
0.03
estimate
0.11
80
706
87
815
1.08
0.23
1.9
1.9
—
—
—
0
0
95
893
1.07
0.23
2.0
2.0
—
—
—
0
0
297
2887
1.04
0.23
3.1
3.5
84.63
63.48
ng/l
0.14
172
1924
5
40
1.25
0.22
1.0
1.1
1781.00
1745.67
miu/ml
—
5
40
30
336
0.89
0.22
1.7
1.8
3.19
4.95
mg/l
0.45
21
241
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
2.60
—
0
6
0
11
0.00
0.21
0.0
6.5
—
9.88
—
0
11
0
10
0.00
0.21
0.0
1.1
—
8.09
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
13
156
0.83
0.21
1.3
1.9
0.55
0.84
nmol/l
—
8
131
79
741
1.07
0.21
2.5
2.1
0.21
0.22
g/l
0.02
70
695
12
98
1.23
0.21
1.2
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
0.04
—
0
7
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
15
126
1.19
0.21
1.1
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
0.00
—
0
8
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
227
2342
0.96
0.20
3.8
4.1
0.00
0.00
estimate
1.08
94
831
0
14
0.00
0.20
0.0
1.0
—
0.68
—
0
9
0
14
0.00
0.20
0.0
2.2
—
0.51
—
0
8
9
111
0.81
0.20
1.0
1.2
—
0.87
—
0
7
6
50
1.20
0.19
1.2
1.2
—
—
—
0
0
18
156
1.16
0.18
1.7
1.5
—
—
—
0
0
34
373
0.91
0.18
1.8
1.5
—
—
—
0
0
38
348
1.10
0.18
3.1
3.4
1.01
1.02
ratio
0.93
38
325
16
138
1.16
0.17
1.2
1.3
—
—
—
0
0
18
157
1.15
0.17
1.1
1.1
11.00
15.05
au/ml
—
5
45
5
67
0.74
0.17
1.0
1.4
—
—
—
0
0
8
69
1.16
0.16
2.6
1.5
—
—
—
0
0
13
111
1.17
0.16
1.1
1.0
0.18
0.33
u/ml
—
6
27
104
999
1.05
0.14
5.4
5.1
2.53
2.30
ug/l
0.14
94
889
8
99
0.81
0.13
1.8
1.8
146.50
209.13
pmol/l
—
8
94
27
247
1.10
0.13
1.1
1.4
—
—
—
0
0
74
706
1.05
0.13
3.0
3.1
5.78
5.81
kpa
0.09
67
690
9
106
0.85
0.13
1.0
1.0
—
—
—
0
0
44
414
1.07
0.12
1.2
1.5
—
—
—
0
0
5
45
1.11
0.10
1.2
1.6
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
46
1.09
0.09
1.2
1.2
—
—
—
0
0
49
468
1.05
0.09
3.7
3.3
5.46
5.16
kpa
0.89
49
454
14
126
1.11
0.09
1.4
1.2
18.69
21.75
u/l
0.16
14
106
27
253
1.07
0.08
1.4
1.8
—
—
—
0
0
5
60
0.83
0.08
1.6
1.0
—
—
—
0
0
7
65
1.08
0.08
3.3
2.2
—
—
—
0
0
8
77
1.04
0.07
1.1
1.1
100.25
108.53
pmol/l
—
8
77
14
153
0.91
0.07
2.1
2.4
5.27
86.15
ug/min
—
9
87
41
393
1.05
0.07
1.4
1.5
—
—
—
0
0
15
138
1.09
0.06
1.1
1.3
292.22
249.88
u/ml
—
9
78
20
187
1.07
0.06
1.6
1.5
—
—
—
0
0
9
102
0.88
0.06
2.1
1.6
—
—
—
0
0
29
276
1.05
0.06
1.6
2.0
—
—
—
0
0
12
131
0.91
0.05
2.3
1.7
—
—
—
0
0
95
969
0.98
0.05
5.3
4.8
32.29
32.82
%
0.17
62
639
38
394
0.96
0.05
2.9
3.2
1.74
1.91
mmol/l
0.10
31
293
20
189
1.06
0.04
1.4
1.4
10.62
14.20
e6/l
0.14
13
145
78
765
1.02
0.04
3.1
3.1
—
—
—
0
0
10
109
0.92
0.04
3.6
3.5
1.02
0.79
nmol/l
—
10
87
20
192
1.04
0.02
1.4
1.5
538.50
171.36
e6/l
0.31
14
151
20
192
1.04
0.02
2.5
4.0
16.55
33.32
u/ml
1.69
20
186
22
213
1.03
0.01
1.8
1.6
—
—
—
0
0
185
1842
1.01
0.01
3.5
4.0
1.02
1.83
kg/l
0.50
129
1237
21
204
1.03
0.00
1.7
1.6
—
—
—
0
0
14
144
0.97
0.00
2.0
1.8
—
—
—
0
0
31
314
0.99
0.00
1.5
2.1
509.08
3930.76
u/l
1.95
12
131
10
102
0.98
0.00
1.0
1.4
—
—
—
0
0
10
102
0.98
0.00
1.0
1.4
—
—
—
0
0
16
162
0.99
0.00
3.6
4.0
196.14
1805.70
u/ml
0.55
16
153
20
202
0.99
0.00
1.3
1.3
—
—
—
0
0
98
977
1.00
0.00
8.1
6.2
104.53
104.16
mmol/l
0.36
98
977
44
439
1.00
0.00
3.0
2.8
132.18
128.97
g/l
0.40
38
429
10
101
0.99
0.00
1.0
1.4
—
—
—
0
0
161
1609
1.00
0.00
1.7
1.7
88406214.59
33579232.69
pmol/l
0.41
138
1358
17
165
1.03
0.00
1.3
1.5
—
—
—
0
0
10
95
1.05
0.00
1.2
1.1
—
—
—
0
0
5
57
0.88
0.00
1.0
1.4
1.24
1.34
promille
—
5
42
0
8
0.00
0.00
0.0
8.6
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
83
0.96
-0.00
1.4
1.1
—
—
—
0
0
9
97
0.93
-0.00
1.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
70.50
—
0
6
9
97
0.93
-0.00
1.0
1.4
—
—
—
0
0
9
98
0.92
-0.00
1.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.01
—
0
6
7
70
1.00
-0.00
1.3
1.0
—
—
—
0
0
13
130
1.00
-0.00
1.3
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_GRAVES_OPHT_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GRAVES_OPHT_STRICT | 1.019 [0.88, 1.18] | 0.809 |
| Birth year | 0.997 [0.99, 1.01] | 0.467 |
During the follow-up period (1.1.1998 — 31.12.2019), 232 out of 2730 females with E4_GRAVES_OPHT_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GRAVES_OPHT_STRICT | 0.955 [0.75, 1.22] | 0.706 |
| Birth year | 0.988 [0.98, 1.0] | 0.021 |
During the follow-up period (1.1.1998 — 31.12.2019), 86 out of 636 males with E4_GRAVES_OPHT_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have E4_GRAVES_OPHT_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.132% | 0.18% |
| 5 | 0.714% | 1.192% |
| 10 | 1.575% | 3.121% |
| 15 | 2.786% | 5.749% |
| 20 | 5.019% | 9.82% |
Relationships between endpoints
↥Index endpoint: E4_GRAVES_OPHT_STRICT – Graves ophthalmopathy, strict
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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