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Frostbite

ST19_FROSTBITE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 T33-T35
  • Cause of death: ICD-10 T33-T35

2 out of 7 registries used, show all original rules.

461

4. Check minimum number of events

None

461

5. Include endpoints

461

6. Filter based on genotype QC (FinnGen only)

409

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
S|T
Name in latin
Congelatio

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 409 143 266
Unadjusted period prevalence (%) 0.10 0.05 0.12
Median age at first event (years) 49.13 44.93 51.38

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
430
Matched controls
4300
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
X31
ICD-10 Finland
Exposure to excessive natural cold
539.1
178.7
166
5
T33.8
ICD-10 Finland
Superficial frostbite of ankle and foot
1279.2
106.0
99
*
T33.5
ICD-10 Finland
Superficial frostbite of wrist and hand
+∞
88.7
82
*
T68
ICD-10 Finland
Hypothermia
55.2
85.3
49
10
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
6.7
55.6
104
196
T34.8
ICD-10 Finland
Frostbite with tissue necrosis of ankle and foot
+∞
51.1
48
*
T33.9
ICD-10 Finland
Superficial frostbite of other and unspecified sites
+∞
44.6
42
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
7.5
41.2
64
98
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
8.9
41.0
54
68
T36
ICD-10 Finland
Poisoning by systemic antibiotics
7.9
40.5
60
87
X59
ICD-10 Finland
Exposure to unspecified factor
4.0
40.3
163
569
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
9.2
39.8
51
62
T34.5
ICD-10 Finland
Frostbite with tissue necrosis of wrist and hand
+∞
39.2
37
*
T35.4
ICD-10 Finland
Unspecified frostbite of upper limb
+∞
37.0
35
*
N05AA02
ATC
levomepromazine; systemic
7.6
36.5
55
81
T35.5
ICD-10 Finland
Unspecified frostbite of lower limb
376.4
35.5
35
*
N07BB01
ATC
disulfiram; oral
6.2
33.3
62
114
T33.4
ICD-10 Finland
Superficial frostbite of arm
+∞
31.7
30
*
N05AH04
ATC
quetiapine; oral
3.5
30.4
136
496
N05AH03
ATC
olanzapine; systemic
4.9
29.7
73
172
X58
ICD-10 Finland
Exposure to other specified factors
3.5
28.7
125
446
AA1AD
NOMESCO Finland
CT of head and brain
3.1
28.0
175
776
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.8
25.3
91
284
F29
ICD-10 Finland
Unspecified nonorganic psychosis
5.5
24.6
51
103
T33.0
ICD-10 Finland
Superficial frostbite of head
+∞
24.2
23
*
F05.9
ICD-10 Finland
Delirium, unspecified
9.9
23.8
28
30
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
8.0
23.7
33
44
P15
ICPC
Chronic alcohol abuse
5.7
23.0
45
86
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.1
20.9
62
168
N05BA04
ATC
oxazepam; oral
2.8
20.3
145
671
F10.20
ICD-10 Finland
Alcohol dependence currently independent
7.2
20.2
31
46
W93
ICD-10 Finland
Exposure to excessive cold of man-made origin
+∞
19.9
19
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.0
19.6
104
409
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.5
19.4
50
121
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.6
19.3
173
892
F10.25
ICD-10 Finland
Alcohol dependence continuous use
7.6
19.3
28
39
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
8.5
18.9
25
31
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
6.4
18.8
32
53
N05CD07
ATC
temazepam; oral
3.5
18.7
73
238
NDQ20
NOMESCO Finland
Amputation of finger
46.2
18.4
22
5
S97
ICPC
Chronic ulcer skin
4.2
18.2
51
132
N05AF03
ATC
chlorprothixene; systemic
6.9
17.7
28
43
F10.24
ICD-10 Finland
Alcohol depence active use
7.4
17.6
26
37
N05AX08
ATC
risperidone; systemic
3.5
17.3
67
217
S06.0
ICD-10 Finland
Concussion
3.2
17.3
81
295
QCB10
NOMESCO Finland
Major dressing of wound of skin of upper limb
7.0
17.2
27
41
NHQ40
NOMESCO Finland
Amputation of toe
12.9
16.6
29
24
G72.8
ICD-10 Finland
Other specified myopathies
6.9
15.9
25
38
SPAT1254
SPAT
Administration of medicine
2.9
15.9
86
340
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.9
15.8
85
334
N06AX11
ATC
mirtazapine; oral
2.3
15.8
176
982
T33.7
ICD-10 Finland
Superficial frostbite of knee and lower leg
+∞
15.7
15
*
W00
ICD-10 Finland
Fall on same level involving ice and snow
3.1
15.6
73
265
S01.0
ICD-10 Finland
Open wound of scalp
3.6
15.5
55
168
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.1
15.5
71
255
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
15.2
96
411
A46
ICD-10 Finland
Erysipelas
2.8
15.0
89
368
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.1
15.0
70
254
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
37.5
14.5
18
5
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
14.5
139
722
P99
ICPC
Psychological disorders other
5.4
14.3
29
57
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.6
14.2
49
147
ZZA00
NOMESCO Finland
Split skin graft
5.2
13.8
29
59
T34.4
ICD-10 Finland
Frostbite with tissue necrosis of arm
+∞
13.6
13
*
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
14.6
12.9
21
15
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
3.7
12.8
43
126
L28
ICPC
Limited function/disability (L)
2.6
12.6
83
361
T35.0
ICD-10 Finland
Superficial frostbite involving multiple body regions
+∞
12.6
12
*
T34.9
ICD-10 Finland
Frostbite with tissue necrosis of other and unspecified sites
+∞
12.6
12
*
S19
ICPC
Skin injury other
4.3
12.3
33
82
X39
ICD-10 Finland
Exposure to other and unspecified forces of nature
38.8
12.3
15
*
N05CF01
ATC
zopiclone; oral
2.2
12.2
152
871
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.9
11.9
61
232
N05AD01
ATC
haloperidol; systemic
4.8
11.8
27
59
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
17.0
11.8
18
11
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
13.0
11.7
20
16
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
9.7
11.6
23
25
N05AB03
ATC
perphenazine; systemic, rectal
4.5
11.4
28
65
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
8.4
11.2
24
30
N05BA01
ATC
diazepam; systemic, rectal
2.6
11.1
69
290
N02AA05
ATC
oxycodone; systemic
2.4
10.9
89
426
S18
ICPC
Laceration/cut
2.0
10.8
211
1409
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.8
10.7
34
96
SPAT1301
SPAT
No procedures
2.1
10.6
141
820
F20.9
ICD-10 Finland
Schizophrenia, unspecified
5.0
10.6
23
48
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.6
10.6
68
291
N06AB04
ATC
citalopram; systemic
2.3
10.5
93
461
NA1AD
NOMESCO Finland
Cervical spine CT examination
3.4
10.0
37
116
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.6
10.0
60
248
SPAT1263
SPAT
Sampling
1.9
10.0
185
1205
N03AX16
ATC
[U] pregabalin
2.2
9.8
103
546
W19
ICD-10 Finland
Unspecified fall
2.7
9.8
58
238
N06AX16
ATC
venlafaxine; oral
2.4
9.7
72
329
N03AG01
ATC
valproic acid; systemic, rectal
3.2
9.7
39
129
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.8
9.7
50
191
N05AF05
ATC
zuclopenthixol; systemic
15.5
9.6
15
10
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
9.5
79
379
B18.2
ICD-10 Finland
Chronic viral hepatitis C
7.8
9.5
21
28
R41.0
ICD-10 Finland
Disorientation, unspecified
4.4
9.5
24
57
S14
ICPC
Burn/scald
3.9
9.5
28
75
N04AA02
ATC
biperiden; systemic
8.3
9.4
20
25
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.9
9.4
45
165
F10.09
ICD-10 Finland
Alcohol intoxication UNS
4.3
9.3
24
58
N03AE01
ATC
clonazepam; systemic
3.3
9.3
35
111
F99
ICD-10 Finland
Mental disorder, not otherwise specified
4.9
9.2
20
42
P19
ICPC
Drug abuse
11.8
9.1
16
14
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
11.8
9.1
16
14
N02BF02
ATC
pregabalin; oral
3.1
8.9
38
130
N05AA01
ATC
chlorpromazine; systemic, rectal
11.0
8.9
16
15
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
9.8
8.8
17
18
ZXD05
NOMESCO Finland
Urgent procedure
1.9
8.6
130
784
Y94.8
ICD-10 Finland
Other leisure activity accident
4.6
8.5
20
45
F39
ICD-10 Finland
Unspecified mood [affective] disorder
5.0
8.4
18
37
S00.0
ICD-10 Finland
Superficial injury of scalp
5.0
8.4
18
37
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.6
8.4
50
205
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
8.8
8.4
17
20
F19.00
ICD-10 Finland
Intoxication caused by several drugs in combination or by other psychoactive substances uncomplicated
+∞
8.4
8
*
T33.6
ICD-10 Finland
Superficial frostbite of hip and thigh
+∞
8.4
8
*
QCB05
NOMESCO Finland
Revision of wound of skin of upper limb
9.7
8.3
16
17
EBA00
NOMESCO Finland
Extraction of tooth
1.8
8.3
178
1197
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.2
8.2
34
114
SPAT1104
SPAT
Monitoring of emergency patient
3.2
8.2
33
109
WX882
NOMESCO Finland
High dependency care
4.9
8.2
18
38
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
3.4
8.1
30
94
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
4.3
8.1
21
51
Z72.2
ICD-10 Finland
Drug use
22.5
8.1
11
5
N06AB10
ATC
escitalopram; oral
2.0
8.0
100
562
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
3.7
8.0
25
70
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.3
7.9
67
323
F03
ICD-10 Finland
Unspecified dementia
4.2
7.9
21
52
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
9.7
7.8
15
16
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
4.3
7.8
20
48
P29
ICPC
Psychological sympt/compl other
2.5
7.8
51
219
N02BF01
ATC
gabapentin; oral
2.6
7.8
47
194
TQW10
NOMESCO Finland
Exchange of bandage for burn
45.8
7.7
9
*
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
3.6
7.7
25
72
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
8.3
7.7
16
20
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
10.3
7.6
14
14
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.5
7.6
50
216
N03AX12
ATC
[U] gabapentin; oral
2.2
7.5
73
373
3018X
ICD-9 Finland
Personality disorders, Other personality disorders[MUU TAI SEKAMUOTOINEN PERSOONALLISUUSHÄIRIÖ]
13.7
7.4
12
9
T74.1
ICD-10 Finland
Physical abuse
4.3
7.3
19
46
A28
ICPC
Limited function/disability NOS
2.1
7.3
73
376
T35.3
ICD-10 Finland
Unspecified frostbite of thorax, abdomen, lower back and pelvis
+∞
7.3
7
*
T34.7
ICD-10 Finland
Frostbite with tissue necrosis of knee and lower leg
+∞
7.3
7
*
T34.0
ICD-10 Finland
Frostbite with tissue necrosis of head
+∞
7.3
7
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.4
7.3
51
226
N06AB03
ATC
fluoxetine; oral
2.3
7.3
56
259
L17
ICPC
Foot/toe symptom/complaint
1.8
7.3
131
829
P20
ICPC
Memory disturbance
2.3
7.2
55
254
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.4
7.1
52
235
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
3.7
7.1
22
61
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.1
7.1
30
102
N07BA03
ATC
varenicline; oral
3.1
7.1
30
102
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.8
7.1
37
142
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.3
7.0
57
270
S82.6
ICD-10 Finland
Fracture of lateral malleolus
3.0
7.0
32
114
S02.20
ICD-10 Finland
Fracture of nasal bones, closed
5.6
7.0
19
35
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
3.9
6.9
20
53
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
3.9
6.9
20
53
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.5
6.9
43
181
S22.3
ICD-10 Finland
Fracture of rib
2.5
6.9
46
200
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.5
6.8
45
194
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
17.0
6.8
10
6
QDD00
NOMESCO Finland
Dressing of major burn of lower limb
17.0
6.8
10
6
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.3
6.7
52
241
Z2446
NOMESCO Finland
Social worker
2.7
6.7
37
146
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
6.6
6.7
16
25
V03AA01, ,
ATC
6.1
6.7
17
29
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
5.5
6.5
18
34
IGV01
NOMESCO Finland
Psychiatric network contact
7.6
6.5
14
19
R42
ICD-10 Finland
Dizziness and giddiness
1.9
6.4
91
531
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.4
6.4
43
187
SPAT1240
SPAT
Therapeutic discussion
2.2
6.4
54
260
J01FF01
ATC
clindamycin; systemic
1.8
6.4
117
740
N03AX09
ATC
lamotrigine; oral
2.9
6.4
29
103
P76
ICPC
Depressive disorder
2.6
6.4
36
144
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
6.3
191
1388
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.6
6.3
38
157
F15.5
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, psychotic disorder
18.3
6.3
9
5
N02AX02
ATC
tramadol; systemic, rectal
1.7
6.3
175
1245
SPAT1265
SPAT
Breathalyser
7.2
6.3
14
20
T35.7
ICD-10 Finland
Unspecified frostbite of unspecified site
+∞
6.3
6
*
R33
ICD-10 Finland
Retention of urine
2.4
6.2
42
183
N05BE01
ATC
buspirone; oral
3.5
6.2
21
62
F60.9
ICD-10 Finland
Personality disorder, unspecified
6.4
6.2
15
24
N06AB06
ATC
sertraline; oral
2.2
6.2
56
277
SPAT1234
SPAT
Support of social functional capacity
3.0
6.2
27
94
ZY010
NOMESCO Finland
Hospital outpatient
2.8
6.2
30
111
B01AB05
ATC
enoxaparin; parenteral
1.8
6.1
118
757
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.7
6.1
126
824
E950A
ICD-9 Finland
Suicide and self-inflicted poisoning by solid or liquid substances
8.8
6.1
12
14
S61.9
ICD-10 Finland
Open wound of wrist and hand, part unspecified
3.2
6.0
24
79

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
28
41
7.24
18.47
2.2
1.4
1.87
1.40
promille
0.56
20
30
99
438
2.64
14.63
2.4
1.7
—
—
—
0
0
90
407
2.53
12.57
9.4
11.3
7.39
7.42
ph
1.71
55
238
40
114
3.77
12.43
4.4
2.7
—
—
—
0
0
88
402
2.50
12.00
9.5
11.3
0.24
0.97
mmol/l
0.60
67
337
180
1123
2.04
11.32
3.7
2.8
59.89
66.20
u/l
0.46
171
1062
163
981
2.07
11.31
6.1
4.5
—
—
—
0
0
22
25
9.21
10.90
2.3
2.6
—
—
—
0
0
258
1862
1.96
10.35
6.2
6.8
11.08
11.97
umol/l
0.70
247
1778
99
506
2.24
10.35
1.9
1.6
1224.78
1171.17
nmol/l
0.21
79
388
217
1487
1.93
10.06
9.4
7.3
1.20
1.21
mmol/l
1.10
210
1381
235
1659
1.92
9.90
10.9
8.1
1.20
1.21
mmol/l
0.86
215
1454
224
1560
1.91
9.81
14.1
12.9
1.20
1.23
inr
0.47
201
1307
199
1334
1.92
9.78
4.8
3.6
223.73
56.75
ng/l
0.40
146
913
49
187
2.83
9.48
5.2
2.8
—
—
—
0
0
53
216
2.66
9.04
6.8
6.6
—
—
—
0
0
91
473
2.17
9.04
7.5
6.6
1.08
1.02
mmol/l
1.30
85
446
74
356
2.30
8.85
5.5
3.9
7.37
7.38
ph
0.79
46
199
58
250
2.53
8.83
3.9
2.0
—
—
—
0
0
210
1470
1.84
8.71
6.5
5.5
34.94
35.99
g/l
1.49
194
1397
60
268
2.44
8.46
4.0
2.0
—
—
—
0
0
328
2659
1.98
8.35
8.4
8.3
80.30
78.00
u/l
0.17
318
2535
70
338
2.28
8.28
5.5
3.8
2.10
1.64
mmol/l
0.43
55
287
52
220
2.55
8.22
4.2
2.0
—
—
—
0
0
71
351
2.23
7.93
5.5
3.8
5.95
5.74
kpa
1.04
66
340
59
271
2.36
7.82
4.0
2.0
—
—
—
0
0
59
271
2.36
7.82
4.0
2.0
—
—
—
0
0
58
269
2.34
7.51
3.6
1.9
—
—
—
0
0
267
2069
1.77
7.36
8.4
5.6
6.68
6.67
mmol/l
0.02
254
1947
51
227
2.41
7.24
2.7
1.6
0.37
0.31
mg/l
0.38
33
115
107
650
1.86
6.70
1.6
1.7
163218830.29
27544282.01
pmol/l
0.60
87
570
181
1289
1.70
6.52
4.4
3.5
39.70
35.09
u/l
0.40
171
1236
130
847
1.77
6.43
5.3
3.5
1.02
1.02
kg/l
0.45
94
574
135
894
1.74
6.29
4.1
3.0
—
—
—
0
0
130
898
1.64
5.01
2.3
2.1
2.97
2.77
mg/l
0.40
116
788
136
956
1.62
4.86
1.7
1.7
18.49
20.44
nmol/l
0.85
123
815
52
277
2.00
4.75
2.2
2.2
5.53
9.00
ug/l
1.17
46
249
206
1602
1.55
4.73
3.5
2.8
—
—
estimate
—
0
0
307
2616
1.61
4.66
5.4
3.4
57.51
49.71
u/l
0.48
296
2504
56
311
1.92
4.55
11.6
11.3
—
—
—
0
0
81
507
1.74
4.47
10.0
8.5
104.12
104.32
mmol/l
0.12
81
507
140
1012
1.57
4.38
5.8
3.7
0.00
0.01
estimate
0.74
44
365
83
528
1.71
4.32
3.1
2.1
—
—
—
0
0
194
1513
1.51
4.26
3.9
3.2
6.42
6.20
ph
1.88
120
884
233
1891
1.51
4.21
4.9
3.6
0.06
0.01
estimate
0.38
48
371
229
1855
1.50
4.16
5.0
3.5
0.00
0.00
estimate
-0.00
50
397
148
1104
1.52
3.95
3.1
3.4
2.34
2.35
mmol/l
0.48
132
1003
229
1875
1.47
3.82
5.0
3.6
0.00
4.07
estimate
0.50
46
399
11
25
4.49
3.64
8.6
10.3
0.58
0.59
mmol/l
0.05
11
25
147
1118
1.48
3.50
2.8
2.4
—
—
—
0
0
79
527
1.61
3.40
2.8
2.6
2.29
2.30
g/l
0.04
72
489
181
1443
1.44
3.33
5.2
3.4
0.02
0.02
estimate
0.09
42
337
10
23
4.43
3.33
1.1
1.7
91.70
74.30
umol/l
—
10
23
148
1137
1.46
3.31
3.8
3.2
54.87
105.71
e6/l
0.39
116
867
36
192
1.95
3.31
4.8
2.6
0.63
0.61
%
0.12
36
192
137
1039
1.47
3.27
7.0
5.9
—
—
—
0
0
83
566
1.58
3.26
2.8
2.5
11.50
13.58
umol/l
1.80
76
534
96
677
1.54
3.25
3.3
2.8
463.27
560.99
mosm/kgh2o
4.80
88
592
132
995
1.47
3.25
5.3
4.1
7.39
7.40
ph
0.63
99
709
108
786
1.50
3.15
3.0
2.6
3.76
4.43
e6/l
0.45
100
710
243
2058
1.42
3.13
9.8
10.0
4.51
4.18
e9/l
1.00
211
1796
181
1456
1.42
3.12
2.4
2.0
93.46
95.95
pmol/l
0.32
114
780
55
343
1.69
3.07
3.1
2.4
0.21
0.22
g/l
0.56
50
316
155
1217
1.43
3.04
6.0
6.4
—
—
—
0
0
116
1500
0.69
2.93
2.7
2.9
—
—
—
0
0
0
73
0.00
2.81
0.0
1.3
—
14.75
—
0
64
12
40
3.06
2.71
2.0
1.8
10.59
11.31
%
0.18
12
40
39
230
1.77
2.67
3.6
3.1
—
—
—
0
0
91
661
1.48
2.66
5.1
3.7
97.62
334.10
ng/l
1.93
68
505
35
202
1.80
2.57
3.6
3.1
165.33
175.00
ng/l
0.04
30
175
120
924
1.41
2.57
3.7
3.1
—
0.00
estimate
—
0
5
67
940
0.66
2.53
2.5
3.0
0.62
0.78
ug/l
1.14
41
559
161
1310
1.37
2.46
4.4
3.8
209.04
120.83
e6/l
0.31
120
922
203
1719
1.34
2.37
6.9
6.7
0.67
0.66
%
0.12
190
1629
46
294
1.63
2.37
3.8
5.6
0.00
0.13
%
2.16
11
83
17
78
2.23
2.34
3.5
2.7
—
—
—
0
0
203
1722
1.34
2.33
6.9
6.6
2.79
2.84
%
0.12
191
1635
69
488
1.49
2.30
3.0
2.6
21.06
24.16
%
0.75
63
466
18
348
0.50
2.29
1.1
1.7
2.95
3.56
mmol/l
—
10
257
48
314
1.60
2.26
3.7
5.4
0.96
0.90
%
0.04
13
105
31
180
1.78
2.26
4.0
3.1
—
—
—
0
0
203
1730
1.33
2.23
6.9
6.7
9.04
8.88
%
0.30
190
1649
222
1919
1.32
2.20
6.8
6.7
0.20
0.19
e9/l
0.09
189
1700
103
793
1.39
2.18
2.0
1.8
1.12
1.32
mg/l
0.35
79
604
215
1855
1.32
2.14
6.9
6.4
0.62
0.59
e9/l
0.78
181
1616
46
306
1.56
2.03
2.3
2.4
1.77
0.50
e6/l
0.44
46
294
26
149
1.79
1.99
2.6
2.2
—
—
—
0
0
120
960
1.35
1.99
3.7
3.2
0.11
0.42
e6/l
3.28
92
706
219
1910
1.30
1.95
7.0
6.5
1.84
1.95
e9/l
0.60
191
1710
60
427
1.47
1.95
2.3
3.1
7.63
8.60
umol/l
0.26
54
386
214
1862
1.30
1.94
6.9
6.4
0.04
0.04
e9/l
0.19
182
1624
205
1776
1.29
1.91
7.1
6.6
26.18
27.54
%
1.06
194
1706
192
1651
1.29
1.89
3.3
2.9
120.01
137.59
ug/l
0.61
178
1555
43
287
1.55
1.88
3.4
3.7
—
—
—
0
0
44
296
1.54
1.86
1.2
1.2
—
—
—
0
0
44
296
1.54
1.86
3.7
5.3
0.36
0.43
%
0.16
11
96
188
1615
1.29
1.85
15.4
11.3
0.00
0.00
e9/l
0.61
160
1323
45
305
1.53
1.85
4.0
6.0
0.00
0.17
%
0.98
11
83
79
600
1.39
1.81
2.5
3.0
2.44
2.44
mmol/l
0.05
64
534
14
68
2.09
1.72
3.9
3.0
1.83
2.31
mmol/l
—
9
45
14
68
2.09
1.72
3.9
3.0
8.09
8.69
kpa
0.71
14
68
14
68
2.09
1.72
3.9
3.0
4.85
5.04
kpa
0.77
14
68
172
1476
1.28
1.67
2.8
2.4
69.73
74.46
nmol/l
1.26
164
1334
50
355
1.46
1.66
3.3
2.8
32.09
33.03
u/l
0.08
45
297
44
305
1.49
1.64
2.2
2.1
0.00
0.00
estimate
—
8
79
18
98
1.87
1.64
4.4
3.1
7.40
7.41
ph
0.73
18
98
287
2630
1.27
1.58
4.4
3.8
14.77
14.78
pmol/l
0.01
263
2396
145
1226
1.28
1.57
4.0
3.4
7.17
8.39
mmol/l
2.18
129
1058
14
71
2.00
1.55
1.7
1.4
—
—
—
0
0
36
244
1.52
1.50
4.6
4.1
127.72
82.94
ng/l
1.65
31
220
30
443
0.65
1.45
1.3
1.3
—
—
—
0
0
7
28
2.52
1.45
1.6
4.2
17.03
16.51
%
—
7
28
5
16
3.15
1.44
1.2
2.0
189.60
114.39
ng/l
—
5
16
10
47
2.15
1.34
2.0
2.3
9.10
10.74
mmol/l
—
10
47
197
1752
1.23
1.33
7.0
6.5
58.96
57.45
%
1.04
192
1690
15
84
1.81
1.28
1.7
1.3
—
—
—
0
0
42
305
1.42
1.27
2.3
3.0
89.86
73.29
e9/l
1.08
27
222
58
446
1.35
1.26
6.1
3.0
5.15
5.87
e9/l
0.23
53
393
10
187
0.52
1.22
2.0
1.6
977.92
914.96
mu/l
—
10
163
22
141
1.59
1.19
2.2
1.9
—
—
—
0
0
12
64
1.90
1.19
3.0
3.0
5.92
4.46
e9/l
0.74
12
64
6
26
2.33
1.19
2.0
3.5
1455.50
941.92
mg
—
6
26
115
976
1.24
1.18
3.2
3.4
2061.61
1271.78
ng/l
0.62
97
818
137
1567
0.82
1.18
4.0
5.0
1.80
2.24
ug/l
0.61
124
1440
127
1092
1.23
1.16
4.3
3.0
0.00
0.01
estimate
0.99
39
320
47
355
1.36
1.15
2.0
1.6
—
—
—
0
0
13
220
0.58
1.14
1.0
1.1
—
—
—
0
0
11
58
1.92
1.13
1.5
1.5
—
—
—
0
0
369
3539
1.30
1.11
26.3
15.0
25.10
24.51
mg/l
0.14
331
2888
369
3539
1.30
1.11
29.7
17.8
4.00
3.98
mmol/l
0.76
364
3470
68
546
1.29
1.10
2.1
1.6
—
—
—
0
0
5
21
2.40
1.09
1.4
1.5
28.60
15.94
umol/l
—
5
21
9
46
1.98
1.04
1.4
2.4
34.22
33.30
pg
—
9
46
0
31
0.00
0.96
0.0
1.1
—
180168.13
—
0
23
0
32
0.00
0.95
0.0
1.1
—
0.08
—
0
5
37
482
0.75
0.93
1.5
1.5
—
—
—
0
0
112
1279
0.83
0.92
1.9
2.0
—
—
—
0
0
6
28
2.16
0.92
1.2
1.1
—
—
—
0
0
21
144
1.48
0.89
1.3
1.4
127.20
288.28
miu/ml
—
5
63
51
408
1.28
0.87
2.0
2.9
2.30
1.90
%
1.01
45
377
28
376
0.73
0.86
1.5
1.7
—
—
—
0
0
6
31
1.95
0.84
4.8
3.1
119.38
20.62
mg/l
—
6
26
6
31
1.95
0.84
2.0
2.0
—
—
—
0
0
8
140
0.56
0.84
1.6
1.6
—
7.73
—
0
30
13
81
1.62
0.82
3.3
3.2
64.31
58.46
%
0.81
13
81
33
425
0.76
0.79
1.5
1.2
—
—
—
0
0
24
174
1.40
0.78
2.5
2.1
0.00
0.00
estimate
—
6
63
81
695
1.20
0.76
2.1
1.7
—
—
—
0
0
5
24
2.10
0.74
1.0
1.0
345.80
286.00
ng/l
—
5
15
5
24
2.10
0.74
1.0
1.0
547.40
614.79
ng/l
—
5
14
67
566
1.22
0.74
3.6
2.9
5.84
1.61
e6/l
0.98
30
285
5
25
2.01
0.73
1.0
1.1
251.40
266.45
mg/l
—
5
20
7
39
1.81
0.73
1.4
4.0
—
—
—
0
0
9
56
1.62
0.72
1.3
1.3
—
—
—
0
0
9
57
1.59
0.71
1.1
1.1
—
—
—
0
0
7
44
1.60
0.65
2.0
2.4
—
—
—
0
0
7
44
1.60
0.65
3.4
3.4
—
—
—
0
0
5
29
1.73
0.64
1.4
3.9
6.20
6.74
mmol/l
—
5
29
120
1081
1.15
0.64
1.4
1.5
—
—
—
0
0
97
861
1.16
0.63
4.3
5.0
—
—
—
0
0
7
114
0.61
0.58
7.6
10.3
—
—
—
0
0
6
36
1.68
0.57
1.7
1.3
—
—
—
0
0
6
37
1.63
0.55
1.3
1.2
—
—
—
0
0
52
444
1.19
0.54
1.8
1.5
—
—
—
0
0
13
93
1.41
0.48
1.5
3.1
0.13
2.48
index
—
8
54
96
874
1.13
0.44
1.3
1.3
1.96
1.64
u/ml
0.15
19
239
36
304
1.20
0.43
3.3
4.2
7.38
7.35
ph
1.46
29
225
6
91
0.65
0.43
1.2
1.1
—
—
—
0
0
20
158
1.28
0.42
1.3
2.3
1.58
5.71
iu/ml
—
5
37
118
1092
1.11
0.41
3.8
4.3
10.52
9.20
mg/mmol
0.15
86
742
380
3731
1.16
0.41
14.2
11.3
28.86
29.33
u/l
0.17
370
3650
32
269
1.20
0.41
4.7
2.3
6.38
6.14
ph
0.65
20
183
5
34
1.48
0.40
1.4
1.8
43.12
40.17
%
—
5
34
94
861
1.12
0.40
2.7
2.1
—
—
—
0
0
7
101
0.69
0.40
1.3
1.1
—
—
—
0
0
8
61
1.32
0.39
1.1
1.1
—
132.33
—
0
12
5
35
1.43
0.39
5.8
1.1
287.60
284.15
mosm/kgh2o
—
5
27
45
512
0.86
0.38
2.5
2.5
14.06
14.17
nmol/l
0.02
35
479
13
169
0.76
0.37
2.7
1.6
—
—
—
0
0
16
125
1.29
0.37
1.1
1.2
—
3.40
—
0
8
5
37
1.36
0.37
2.2
2.9
1.22
1.19
mmol/l
—
5
37
5
37
1.36
0.37
2.2
2.9
4.32
4.08
mmol/l
—
5
37
5
37
1.36
0.37
1.4
1.4
2.68
2.79
g/l
—
5
26
5
37
1.36
0.37
2.2
2.9
108.00
105.35
mmol/l
—
5
37
5
37
1.36
0.37
1.4
1.4
—
—
—
0
0
5
37
1.36
0.37
1.4
1.4
0.34
0.34
g/l
—
5
25
5
37
1.36
0.37
1.4
1.4
5.92
6.70
g/l
—
5
26
9
70
1.29
0.37
1.0
1.1
—
—
—
0
0
14
109
1.29
0.34
1.4
1.3
—
—
—
0
0
6
47
1.28
0.32
3.5
2.7
0.60
0.97
nmol/l
—
6
40
7
52
1.35
0.31
1.1
1.6
—
—
—
0
0
7
52
1.35
0.31
1.1
1.6
—
—
—
0
0
7
52
1.35
0.31
1.1
1.6
—
—
—
0
0
7
52
1.35
0.31
1.1
1.6
—
—
—
0
0
18
147
1.23
0.31
2.9
2.6
558.96
5856.11
u/l
—
5
64
11
141
0.77
0.30
1.3
1.2
—
—
—
0
0
153
1460
1.07
0.27
2.0
1.9
1.31
1.41
mmol/l
1.12
135
1254
8
65
1.24
0.27
1.1
1.0
3.42
2.93
u/ml
—
8
30
113
1068
1.08
0.26
3.3
3.6
54.05
58.30
mg/l
0.09
85
741
51
465
1.11
0.25
1.9
1.9
—
—
—
0
0
18
212
0.84
0.24
1.3
1.2
—
—
—
0
0
37
410
0.89
0.23
1.9
1.4
—
—
—
0
0
5
38
1.32
0.23
1.0
1.3
—
—
nmol/l
—
0
0
19
162
1.18
0.23
1.4
1.3
—
—
—
0
0
34
378
0.89
0.22
1.3
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
4.5
—
—
—
0
0
0
12
0.00
0.21
0.0
3.9
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
3.2
—
9.16
—
0
13
0
13
0.00
0.21
0.0
2.0
—
2.38
—
0
13
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
324
3188
1.07
0.20
5.6
4.7
1.92
1.90
mu/l
0.09
301
2961
324
3290
0.94
0.20
4.0
4.1
1.32
1.32
mmol/l
0.01
298
3063
6
50
1.20
0.20
1.2
1.2
—
—
—
0
0
25
223
1.13
0.18
1.7
1.3
—
40.29
—
0
17
7
59
1.19
0.18
1.6
1.2
—
—
—
0
0
24
214
1.13
0.18
1.8
2.0
48.25
37.63
nmol/l
0.60
24
208
329
3247
1.06
0.16
6.3
6.0
39.19
39.15
mmol/mol
0.02
305
3075
8
73
1.10
0.16
1.3
1.0
1.24
1.41
u/ml
—
8
40
9
81
1.11
0.15
3.3
3.7
—
—
—
0
0
7
86
0.81
0.14
2.9
1.3
—
—
—
0
0
371
3678
1.06
0.14
23.3
12.9
—
—
—
0
0
389
3917
0.93
0.14
36.7
22.2
7.10
6.75
e9/l
2.27
379
3839
46
487
0.94
0.12
2.2
2.5
137.17
118.05
ug/g
0.13
38
393
87
903
0.95
0.12
2.6
2.8
346.96
357.40
umol/l
0.36
75
804
389
3914
0.94
0.12
37.6
22.8
40.29
41.26
%
3.16
383
3876
389
3914
0.94
0.12
36.4
22.1
30.32
30.35
pg
0.10
383
3880
389
3914
0.94
0.12
36.5
22.2
4.47
4.61
e12/l
4.95
379
3837
75
779
0.95
0.11
1.5
1.4
2.89
2.47
g/l
0.60
44
500
29
311
0.93
0.11
2.8
4.5
3.06
23.71
ug/l
0.89
24
258
23
212
1.09
0.10
1.2
2.4
—
—
—
0
0
389
3912
0.94
0.10
36.5
22.2
91.00
90.62
fl
0.80
383
3879
63
605
1.05
0.10
1.2
1.3
27.23
28.60
iu/ml
0.04
23
180
5
44
1.14
0.10
6.6
2.2
2.44
-0.03
mmol/l
—
5
44
389
3911
0.94
0.09
36.5
22.2
242.78
245.62
e9/l
0.34
379
3843
5
48
1.04
0.09
1.0
1.4
0.30
0.49
nmol/l
—
5
41
7
81
0.86
0.07
1.0
1.1
—
—
—
0
0
7
81
0.86
0.07
1.0
1.1
—
—
—
0
0
7
82
0.85
0.07
1.3
1.1
8.27
5.73
u/ml
—
7
52
15
163
0.92
0.07
1.1
1.1
—
—
—
0
0
343
3451
0.97
0.07
4.6
4.8
1.34
1.38
mmol/l
0.88
321
3234
390
3916
0.96
0.06
36.7
22.3
134.40
138.98
g/l
5.92
385
3880
46
444
1.04
0.06
1.4
1.3
—
—
—
0
0
10
110
0.91
0.05
1.0
2.1
9.75
10.56
g/l
—
10
103
56
546
1.03
0.04
1.2
1.3
1.19
6.45
u/ml
3.10
19
210
306
3075
0.98
0.03
29.9
18.5
332.49
334.31
g/l
2.47
301
3064
12
129
0.93
0.03
2.6
4.2
175.86
372.66
mg/l
—
7
65
336
3346
1.02
0.03
5.0
4.7
5.94
5.92
mmol/l
0.08
308
3091
28
270
1.04
0.03
1.4
1.4
—
—
—
0
0
11
118
0.93
0.03
1.3
1.2
—
—
—
0
0
17
178
0.95
0.02
1.1
1.1
0.90
0.93
g/l
0.16
17
178
13
137
0.95
0.01
2.4
2.5
—
—
—
0
0
22
227
0.97
0.01
1.2
1.3
10.44
107.46
u/ml
—
5
82
11
104
1.06
0.01
1.0
1.2
—
—
—
0
0
17
176
0.96
0.00
1.1
1.1
1.50
1.50
g/l
0.04
17
176
19
192
0.99
0.00
1.6
1.2
—
—
—
0
0
351
3512
1.00
0.00
5.3
5.4
2.64
2.72
mmol/l
0.81
331
3292
347
3467
1.00
0.00
4.8
4.9
4.47
4.57
mmol/l
0.99
325
3268
6
65
0.92
0.00
9.7
3.2
17.73
8.60
pmol/l
—
6
65
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
80
1.00
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.7
—
8374.67
—
0
9
0
7
0.00
-0.00
0.0
1.7
—
58.00
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
1.20
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
41.00
—
0
5
13
130
1.00
-0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.8
—
6.68
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
64.83
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
48.50
—
0
6
48
480
1.00
-0.00
1.4
1.4
230.00
467.37
titre
2.77
12
95
0
9
0.00
-0.00
0.0
1.3
—
80.22
—
0
9
9
93
0.97
-0.00
1.0
1.3
—
2.74
—
0
12
7
78
0.90
-0.00
1.3
1.1
0.37
2.50
u/ml
—
7
38
9
99
0.91
-0.00
1.9
1.9
—
—
—
0
0
5
58
0.86
-0.00
2.8
2.4
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: ST19_FROSTBITE – Frostbite

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).