Pneumoconiosis due to other inorganic dusts

J10_INORGPNEUMOC

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — J63 Hospital discharge: ICD-9 — 503 Hospital discharge: ICD-8 — 51600 Cause of death: ICD-10 — J63 Cause of death: ICD-9 — 503 Cause of death: ICD-8 — 51600 2 out of 7 registries used, show all original rules.	151
4. Check minimum number of events None	151
5. Include endpoints None	151
6. Filter based on genotype QC (FinnGen only)	133

Control definitions (FinnGen only)

Control exclude: J10_EXTERLUNG

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: J60-J70
Name in latin: Pneumoconiosis ex aliis pulveribus inorganicis

NAME	J10_INORGPNEUMOC
CONTROL_EXCLUDE	J10_EXTERLUNG
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	J63
HD_ICD_9	503
HD_ICD_8	51600
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	J63
COD_ICD_9	503
COD_ICD_8	51600
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Pneumoconiosis due to other inorganic dusts based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1874	796	1036
Only index persons	1034	447	587
Unadjusted period prevalence (%)
Whole population	0.03	0.02	0.03
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	72.58	76.03	69.86
Only index persons	68.26	72.40	65.11

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	133	40	93
Unadjusted period prevalence (%)	0.03	0.01	0.04
Median age at first event (years)	68.43	65.91	69.52

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
135: Matched controls
1350

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

J63.3

ICD-10 Finland

Graphite fibrosis (of lung)

+∞

53.8

I63.3

ICD-10 Finland

Cerebral infarction due to thrombosis of cerebral arteries

15.5

46.9

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

10.7

42.1

108

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

6.9

27.8

160

J63.8

ICD-10 Finland

Pneumoconiosis due to other specified inorganic dusts

+∞

25.9

J63.4

ICD-10 Finland

Siderosis

+∞

22.5

B01AC30

ATC

platelet aggregation inhibitors excl. heparin - combinations

5.5

14.8

B01AC07

ATC

dipyridamole; systemic

4.6

11.4

J69.0

ICD-10 Finland

Pneumonitis due to food and vomit

118.9

10.6

I63.4

ICD-10 Finland

Cerebral infarction due to embolism of cerebral arteries

8.4

9.7

J63.1

ICD-10 Finland

Bauxite fibrosis (of lung)

+∞

9.5

J63.0

ICD-10 Finland

Aluminosis (of lung)

+∞

8.4

B01AC04

ATC

clopidogrel; oral

2.9

7.4

211

51600

ICD-8 Finland

Other pneumoconiosis and related diseases, Due to inhalation of other inorganic dust

+∞

7.4

AA1AD

NOMESCO Finland

CT of head and brain

2.6

6.5

322

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.5

6.5

379

J63.5

ICD-10 Finland

Stannosis

+∞

6.3

5030A

ICD-9 Finland

Pneumoconiosis due to other inorganic dust[PNEUMOCONIOSIS ALIA DEFINITA]

+∞

6.3

I63.1

ICD-10 Finland

Cerebral infarction due to embolism of precerebral arteries

8.3

6.3

K90

ICPC

Stroke/cerebrovascular accident

6.1

6.2

111

Kela drug reimbursment

Epilepsy and comparable convulsive disorders

5.9

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.89

3.36

4.3

6.4

25.64

24.74

mmol/l

0.50

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

6.08

3.06

2.4

2.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.44

2.75

2.1

1.7

—

(3019977) pH of Arterial blood

138

2.09

2.64

6.0

6.6

7.42

0.04

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

375

0.51

2.25

6.5

5.0

22.41

22.34

—

199

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

5.72

2.23

1.2

—

(3049717) Cytology report of Urine Cyto stain

2.48

2.01

1.8

2.3

—

(3035941) MCH [Entitic mass]

895

0.64

1.79

49.0

30.4

30.42

30.46

0.06

886

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

895

0.64

1.79

50.6

31.0

39.84

38.93

0.91

885

(3026361) Erythrocytes [#/volume] in Blood

895

0.64

1.79

49.2

30.5

4.34

4.33

e12/l

0.06

874

(3007461) Platelets [#/volume] in Blood

894

0.64

1.77

49.0

30.6

237.65

237.04

e9/l

0.03

879

(3024731) MCV [Entitic mean volume] in Red Blood Cells

894

0.64

1.77

49.0

30.5

92.53

91.85

0.53

885

(40760888) Immunoglobulin light chains.free panel - Serum

3.25

1.68

1.2

4.3

—

(40761511) CBC panel - Blood by Automated count

841

0.65

1.65

30.8

19.0

—

(3000494) Fungus identified in Specimen by Culture

101

1.90

1.58

2.4

1.4

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

790

0.68

1.41

9.3

7.5

43.79

41.02

mmol/mol

1.03

717

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

485

0.65

1.40

5.6

5.7

1.99

2.56

ug/l

0.60

419

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.28

1.40

1.1

1.4

—

(3000991) Gas panel - Venous blood

1.91

1.38

8.7

7.7

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

891

0.68

1.33

41.5

27.6

90.53

88.25

umol/l

0.12

877

(3020630) Protein [Mass/volume] in Serum or Plasma

1.80

1.24

1.3

2.3

67.46

66.22

g/l

0.30

(3014576) Chloride [Moles/volume] in Serum or Plasma

151

1.63

1.22

5.9

6.9

105.00

103.68

mmol/l

0.66

151

(3027315) Oxygen [Partial pressure] in Blood

2.37

1.20

2.2

3.3

7.28

7.94

kpa

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.37

1.20

2.2

3.3

5.22

5.20

kpa

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.90

1.13

1.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

114

1.67

1.09

10.3

9.7

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

2.18

1.07

1.0

3.3

1.17

4.60

ratio

—

(3025941) Bacteria identified in Stool by Culture

2.02

1.06

1.6

1.3

—

(3019309) Folate [Moles/volume] in Red Blood Cells

253

1.46

1.04

2.1

1.8

1301.08

1191.35

nmol/l

0.36

193

(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma

2.05

1.01

1.0

3.2

52.69

38.95

mg/l

—

(3034860) Kappa light chains.free [Mass/volume] in Serum

2.05

1.01

1.0

3.2

45.46

65.15

mg/l

—

(3010421) pH of Blood

1.99

0.98

2.4

3.7

7.41

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

860

0.73

0.97

17.0

12.7

22.38

22.46

u/l

0.03

828

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

772

0.74

0.96

6.4

4.9

1.93

2.02

mu/l

0.27

673

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

811

0.74

0.96

6.3

5.7

6.49

6.16

mmol/l

0.59

712

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

810

0.74

0.94

6.8

6.1

2.13

2.42

mmol/l

2.37

722

(3007853) Bacteria identified in Skin by Aerobe culture

119

1.59

0.94

3.7

2.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.71

0.92

1.3

2.2

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.91

0.89

2.6

1.6

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

786

0.75

0.88

5.8

5.3

3.84

4.25

mmol/l

3.29

704

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.75

0.85

3.5

1.8

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

782

0.76

0.82

5.8

5.2

1.28

1.40

mmol/l

2.17

694

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.71

0.80

2.9

1.8

—

(3020891) Body temperature

1.75

0.77

1.4

4.1

36.68

36.91

°c

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.65

0.74

1.8

3.3

24.10

23.44

mmol/l

—

(1616796) Gas panel - Central venous blood

1.96

0.71

2.6

3.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

217

1.37

0.69

3.0

1.9

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

1.88

0.69

1.6

1.3

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

103

1.51

0.68

4.6

2.4

4.09

10.01

umol/l

2.20

(40768797) Stomach Pathology biopsy report

126

0.61

0.68

2.0

1.3

—

(3023368) Bacteria identified in Blood by Culture

367

1.30

0.67

7.5

4.5

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

620

0.78

0.66

5.0

3.8

15.47

15.15

pmol/l

0.40

540

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

378

1.29

0.64

4.8

3.4

—

(3037756) Immunofixation for Serum or Plasma

1.75

0.64

1.4

1.3

—

(3020779) Urea [Moles/volume] in Serum or Plasma

1.53

0.63

7.8

6.2

9.22

11.95

mmol/l

0.90

(42868678) Cholesterol non HDL [Moles/volume] in Serum or Plasma

0.00

0.61

0.0

2.3

—

3.19

—

(3032080) INR in Blood by Coagulation assay

526

1.25

0.60

31.5

20.1

1.51

1.41

inr

0.59

453

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

499

1.25

0.57

10.1

7.6

1.21

mmol/l

0.06

426

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.65

0.56

4.2

1.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

152

1.37

0.56

1.2

1.5

2.92

2.90

g/l

0.01

(3019060) Gas panel - Arterial blood

1.45

0.49

2.7

3.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.51

0.48

1.8

1.3

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

754

0.83

0.48

4.7

4.5

1.29

1.22

mmol/l

0.40

662

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

472

1.20

0.43

5.5

4.9

30.22

57.29

ng/l

1.73

377

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

405

1.21

0.42

3.4

3.7

2618.95

2111.28

ng/l

0.26

340

(40761536) Microorganisms panel - Urine sediment

1.43

0.42

7.3

3.9

—

(3026493) Urate [Moles/volume] in Serum or Plasma

253

1.24

0.41

4.1

3.0

349.83

367.11

umol/l

0.31

204

(3008898) HLA-B27 [Presence]

0.00

0.41

0.0

1.1

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.41

0.0

1.3

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.41

0.0

1.1

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

310

1.22

0.41

2.6

2.4

3.45

3.01

mg/l

0.57

272

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.41

0.0

1.1

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

158

0.74

0.40

5.3

3.3

1.40

2.48

e6/l

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

1.44

0.39

1.4

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

143

1.30

0.39

2.9

1.9

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.39

0.39

1.7

1.4

—

(3014051) Protein [Presence] in Urine by Test strip

222

0.78

0.38

3.2

3.7

—

0.00

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

136

1.29

0.35

3.2

4.4

219.12

247.63

u/l

0.87

126

(3044889) 12 lead EKG panel

612

0.85

0.35

5.9

4.8

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.41

0.35

1.7

1.2

18.82

321.07

u/ml

—

(3013512) EKG study

377

0.83

0.35

4.7

4.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

282

0.82

0.34

5.5

3.6

0.00

0.02

estimate

0.49

(3018010) Neutrophils/Leukocytes in Blood

426

0.85

0.32

10.9

5.8

61.66

59.31

0.55

404

(3022096) Basophils/Leukocytes in Blood

426

0.85

0.32

13.3

6.0

0.56

0.58

0.09

400

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.29

0.32

5.5

2.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

386

1.17

0.31

3.0

2.4

—

(36660697) Celiac disease serology panel - Serum

1.31

0.31

1.3

1.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

158

1.24

0.30

2.9

1.8

—

(3006504) Eosinophils/Leukocytes in Blood

423

0.86

0.30

13.1

6.0

2.33

2.71

0.69

397

(3021960) Folate [Moles/volume] in Serum or Plasma

319

0.85

0.29

1.8

21.30

19.77

nmol/l

0.18

254

(46236952) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)/1.73 sq M

0.68

0.27

1.2

2.9

—

62.24

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

218

1.18

0.25

7.2

3.6

282.03

330.51

ng/l

0.08

196

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.21

0.25

10.1

3.2

2.38

1.77

mmol/l

—

(3042936) Bacteria identified in Isolate by Culture

153

1.20

0.24

2.1

2.0

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

172

1.19

0.23

3.9

2.4

19.27

21.62

0.55

162

(3002582) Erythrocytes [#/volume] in Urine

355

1.14

0.23

5.1

3.4

62.70

251.70

e6/l

0.52

280

(4035726) Immunohistochemistry procedure

0.76

0.23

1.4

1.3

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

1.6

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

759.23

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(4146454) Self-monitoring of blood glucose

0.00

0.21

0.0

2.8

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

1.65

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.21

0.0

2.2

—

590.33

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

456

1.12

0.21

2.8

2.3

114.26

92.78

pmol/l

1.33

236

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.3

—

72.88

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

0.83

—

(3017569) Oxygen content in Arterial blood

0.00

0.20

0.0

7.1

—

15.76

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.23

0.20

3.0

2.6

—

(40768804) Tissue Pathology biopsy report

351

0.88

0.20

2.1

2.2

—

(3019069) Monocytes/Leukocytes in Blood

422

0.89

0.19

13.2

6.1

8.65

9.24

0.48

397

(3017732) Neutrophils [#/volume] in Blood

109

1.21

0.19

5.7

2.9

3.83

4.14

e9/l

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.25

0.19

1.9

1.3

—

(3029937) Albumin [Presence] in Urine by Test strip

301

1.13

0.19

7.5

4.4

0.00

estimate

-0.00

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

226

0.86

0.19

2.4

3.3

2.43

2.46

mmol/l

0.93

201

(3012544) pH of Venous blood

110

1.20

0.18

1.6

3.9

7.39

7.38

—

(3020682) Albumin/Creatinine [Ratio] in Urine

328

0.89

0.18

5.2

4.2

29.66

9.63

mg/mmol

0.37

216

(3022313) Gas panel - Capillary blood

1.16

0.18

11.9

3.0

—

(3000492) Spirometry study

1.16

0.18

1.7

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

206

1.14

0.17

2.2

1.8

0.74

1.70

mg/l

2.64

167

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.22

0.16

1.7

1.5

—

(40758558) Short blood count panel - Blood

264

0.89

0.15

7.2

6.9

—

(3003694) ABO and Rh group [Type] in Blood

212

0.88

0.15

1.5

1.4

—

(3002256) Pathology report gross observation

118

0.84

0.15

1.2

1.3

—

(3002030) Lymphocytes/Leukocytes in Blood

426

0.91

0.14

12.5

6.1

25.66

24.95

0.10

405

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

0.83

0.14

4.6

3.0

198.75

254.91

ng/l

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

161

1.14

0.13

1.4

1.2

7.63

1.09

u/ml

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

113

1.17

0.13

1.2

1.3

103.41

42.60

iu/ml

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.19

0.13

1.6

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

655

0.93

0.13

7.3

4.6

21.45

14.97

mm/h

1.61

599

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

388

1.08

0.12

6.3

4.4

0.00

0.02

estimate

0.49

(3009261) Glucose [Presence] in Urine by Test strip

502

0.93

0.11

6.5

4.5

0.00

estimate

—

100

(1761868) Lipid panel - Serum or Plasma

218

0.90

0.11

2.4

3.8

—

(3009508) Creatinine [Moles/volume] in Urine

319

0.92

0.10

4.0

3.4

6.65

7.41

mmol/l

0.41

264

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.17

0.10

1.4

1.3

—

(3012516) Albumin [Mass/volume] in Urine

318

0.93

0.09

4.1

3.4

123.92

66.85

mg/l

0.50

222

(42870588) Differential panel, method unspecified - Blood

327

0.93

0.08

11.5

5.6

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.04

0.08

6.8

1.6

1.82

1.67

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.04

0.08

1.2

1.8

—

(3026008) Bacteria identified in Urine by Culture

333

1.07

0.08

5.8

3.9

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

235

1.08

0.08

3.1

2.8

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.03

0.08

2.6

1.4

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

453

1.06

0.07

5.5

5.2

33.72

34.30

g/l

0.23

424

(3022145) Colonoscopy Study observation

0.83

0.07

1.6

1.3

—

(3035350) Ketones [Presence] in Urine by Test strip

495

0.95

0.06

6.4

4.4

0.00

14.50

estimate

0.50

112

(3018418) pH of Serum or Plasma

287

1.06

0.06

3.3

4.2

7.40

0.13

217

(3021447) Carbon dioxide [Partial pressure] in Venous blood

111

1.09

0.04

1.7

3.9

6.16

5.72

kpa

0.52

106

(3015377) Calcium [Moles/volume] in Serum or Plasma

341

0.96

0.04

3.1

3.4

2.32

2.33

mmol/l

0.32

306

(3021601) Nitrite [Presence] in Urine by Test strip

491

0.97

0.03

6.4

4.4

0.00

estimate

-0.00

107

(40760892) CBC W Ordered Manual Differential panel - Blood

179

0.94

0.03

6.1

4.7

—

(3015736) pH of Urine

400

1.04

0.03

5.5

4.0

6.43

6.25

0.43

222

(3044640) Blood type and Crossmatch panel - Blood

319

0.96

0.02

3.5

2.8

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

388

0.97

0.02

2.8

2.3

79.97

76.66

nmol/l

0.26

326

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

166

0.96

0.00

4.6

3.2

0.93

1.23

e6/l

—

102

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

116

1.04

0.00

7.4

3.7

—

(3018095) Leukocytes [#/volume] in Urine

381

1.00

0.00

5.7

4.1

37.54

65.87

e6/l

0.56

293

(3019150) Specific gravity of Urine by Refractometry

225

0.97

0.00

7.0

4.9

1.02

kg/l

0.50

152

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

414

0.99

0.00

3.5

3.2

—

estimate

—

(3004451) EKG impression Narrative

0.00

0.0

1.2

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

0.00

0.0

1.3

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.1

—

(4281824) Cell count and differential, peritoneal fluid

0.00

0.0

1.0

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

-0.00

0.0

1.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

-0.00

0.0

1.4

—

(3027944) Amphetamines [Presence] in Urine

0.00

-0.00

0.0

1.4

—

(3027008) Opiates [Presence] in Urine

0.00

-0.00

0.0

1.4

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

2.9

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

-0.00

0.0

1.0

—

(3014891) Appearance of Pleural fluid

0.00

-0.00

0.0

1.2

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.1

—

(3002079) Sodium [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.2

—

148.40

—

(3033799) Differential panel - Peritoneal fluid

0.00

-0.00

0.0

1.0

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

-0.00

0.0

1.3

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.0

—

(44806420) Estimation of glomerular filtration rate

0.00

-0.00

0.0

2.7

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.3

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.8

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

-0.00

0.0

2.2

—

(4268621) Lupus anticoagulant assay

0.00

-0.00

0.0

1.8

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate

0.00

-0.00

0.0

7.4

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

(3000919) Neutrophils/Leukocytes in Pleural fluid

0.00

-0.00

0.0

1.7

—

26.59

—

(3016879) Cocaine [Presence] in Urine

0.00

-0.00

0.0

1.4

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.1

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

174.00

—

(3037534) Parathyrin related protein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

69.42

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.2

—

82.80

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

-0.00

0.0

1.6

—

(3011648) Oxygen content in Venous blood

0.00

-0.00

0.0

1.8

—

9.75

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.6

—

(3036603) Volume of Urine

0.00

-0.00

0.0

1.0

—

1376.00

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

-0.00

0.0

1.4

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

-0.00

0.0

1.8

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

-0.00

0.0

1.0

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.3

—

51.32

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.3

—

105.00

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

-0.00

0.0

1.0

—

(3009343) pH of Capillary blood

1.00

-0.00

10.4

3.1

7.42

7.43

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

(3028300) Cannabinoids [Presence] in Urine

0.00

-0.00

0.0

1.4

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.00

-0.00

4.6

4.1

1.20

1.22

mmol/l

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

4.6

—

52.80

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.3

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.8

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.2

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint J10_INORGPNEUMOC and mortality.

Females

Parameter	HR [95% CI]	p-value
J10_INORGPNEUMOC	2.348 [1.93, 2.85]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.312

During the follow-up period (1.1.1998 — 31.12.2019), 396 out of 557 females with J10_INORGPNEUMOC died.

Males

Parameter	HR [95% CI]	p-value
J10_INORGPNEUMOC	2.514 [2.05, 3.08]	< 0.001
Birth year	0.985 [0.98, 1.0]	0.004

During the follow-up period (1.1.1998 — 31.12.2019), 496 out of 715 males with J10_INORGPNEUMOC died.

Mortality risk

Mortality risk for people of age

years, who have J10_INORGPNEUMOC.

N-year risk	Females	Males
1	0.211%	0.488%
5	1.365%	2.745%
10	3.496%	6.969%
15	6.78%	12.907%
20	11.869%	21.3%

Relationships between endpoints

↥

Index endpoint: J10_INORGPNEUMOC – Pneumoconiosis due to other inorganic dusts

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Pneumoconiosis due to other inorganic dusts

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints