nodular goiter: Goiter characterized by discrete tissue mass(es) that may or may not produce thyroid hormones.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3286 |
4. Check minimum number of eventsNone |
3286 |
5. Include endpointsNone |
3286 |
6. Filter based on genotype QC (FinnGen only) |
2987 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E04
- Name in latin
- Struma atoxica uninodularis
Similar endpoints
↥List of similar endpoints to
Nontoxic single thyroid nodule
based on the number of shared cases.
Similar with more cases:
- Nontoxic goitre/thyroid nodule
- Benign thyroid growths and nodules
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17821 | 14391 | 3351 |
| Only index persons | 16839 | 13735 | 3104 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.35 | 0.41 | 0.09 |
| Only index persons | 0.43 | 0.50 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 51.50 | 50.54 | 55.53 |
| Only index persons | 50.93 | 50.05 | 54.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2987 | 2410 | 577 |
| Unadjusted period prevalence (%) | 0.74 | 0.86 | 0.26 |
| Median age at first event (years) | 51.86 | 49.93 | 59.93 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 3091
- Matched controls
- 30910
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E03
ICD-10 Finland
Other hypothyroidism
86.8
307.7
255
32
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
61.5
307.7
466
89
T86
ICPC
Hypothyroidism/myxoedema
65.2
307.7
224
37
104
Kela drug reimbursment
Thyroid insufficiency
601.2
307.7
463
9
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
60.7
307.7
287
52
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
619.1
307.7
1004
24
2410A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic uninodular goitre
+∞
307.7
318
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
95.5
307.7
230
26
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
109.2
307.7
621
71
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
208.2
307.7
768
49
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
7549.7
307.7
2697
28
EP1AE
NOMESCO Finland
Neck ultrasound examination
9.9
307.7
594
727
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
67.9
307.7
438
75
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
51.5
307.7
352
77
H03AA01
ATC
levothyroxine sodium; systemic
60.6
307.7
1327
379
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
2830.9
283.6
270
*
2504
FHL
Unilateral resection or enucleation
992.2
281.7
272
*
BAA60
NOMESCO Finland
Total thyroidectomy
2375.5
241.7
231
*
H03BB01
ATC
carbimazole; oral
60.7
229.7
128
22
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
1921.2
199.0
191
*
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
209.7
173.0
178
9
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
203.5
167.8
173
9
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
+∞
160.8
153
*
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
269.5
127.1
129
5
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
4.9
112.3
264
582
BA1AE, ,
SPAT
10.7
106.5
117
113
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
355.6
103.8
104
*
E04
ICD-10 Finland
Other nontoxic goitre
40.8
98.9
60
15
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
957.3
95.5
93
*
2462A
ICD-9 Finland
Other disorders of thyroid, Cyst of thyroid
+∞
90.0
86
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
158.0
87.6
92
6
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
851.3
85.0
83
*
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
7.6
80.3
115
156
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
267.2
76.8
78
*
T81
ICPC
Goitre
24.5
74.6
53
22
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
29.7
66.2
44
15
JN5PN
NOMESCO Finland
Isotope imaging of secondary neoplasms of thyroid origin
+∞
58.5
56
*
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
24.4
57.6
41
17
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
568.3
56.8
56
*
EP1AE, ,
SPAT
4.5
54.0
134
307
E04.8
ICD-10 Finland
Other specified nontoxic goitre
76.6
53.2
60
8
C73.90
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland) without histology
+∞
47.0
45
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
162.5
45.9
48
*
8330/3-C73.9
ICD-O-3
Follicular carcinoma, NOS, of thyroid gland
+∞
43.8
42
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.7
40.6
231
898
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
+∞
37.6
36
*
QX3LT
NOMESCO Finland
Subcutaneous sclerotherapy
70.8
37.0
42
6
A02BC05
ATC
esomeprazole; systemic
1.6
36.9
1315
9650
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
34.7
750
4815
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
34.4
33
*
TBA20
NOMESCO Finland
Aspiration cytology of thyroid gland
+∞
33.4
32
*
BAA30
NOMESCO Finland
Excision of thyroid isthmus
91.1
32.8
36
*
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
91.1
32.8
36
*
C73.99
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland), other or unspecified histology
+∞
32.3
31
*
R13
ICD-10 Finland
Dysphagia
2.3
31.8
249
1122
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
7.0
31.0
47
68
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
29.2
28
*
C73
ICD-10 Finland
Malignant neoplasm of thyroid gland
+∞
28.2
27
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
273.4
26.8
27
*
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
+∞
26.1
25
*
106
Kela drug reimbursment
Hypoparathyroidism
40.4
25.8
32
8
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
262.8
25.7
26
*
E06.3
ICD-10 Finland
Autoimmune thyroiditis
26.4
24.8
34
13
J37.0
ICD-10 Finland
Chronic laryngitis
2.7
24.1
128
480
E07.89
ICD-10 Finland
Other specified disorders of thyroid
54.4
23.1
27
5
N02BE01
ATC
paracetamol; systemic, rectal
1.8
22.6
2776
25600
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
22.0
342
1973
JN5AQ
NOMESCO Finland
SPECT of thyroid metastasis with low-dose CT
+∞
21.9
21
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.7
21.8
117
441
E06.9
ICD-10 Finland
Thyroiditis, unspecified
38.9
21.7
27
7
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
21.1
860
6309
2506
FHL
Thyroidectomy
+∞
20.9
20
*
BA4KT
NOMESCO Finland
Sclerotherapy of thyroid
+∞
20.9
20
*
R49.08
ICD-10 Finland
Other specified dysphonia
3.0
20.8
92
312
T71
ICPC
Malignant neoplasm thyroid
211.4
20.6
21
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
20.2
1088
8421
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
20.0
1118
8709
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
19.8
925
6958
BAA99
NOMESCO Finland
Other operation on thyroid gland
+∞
19.8
19
*
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
201.2
19.6
20
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
19.5
759
5503
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
18.8
819
6068
4CJ01, ,
NOMESCO Finland
+∞
18.8
18
*
R49.01
ICD-10 Finland
Functional dysphonia
2.5
18.2
114
464
BA2AT
NOMESCO Finland
Biopsy of thyroid with ultrasound quidance
44.3
18.2
22
5
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
21.8
18.2
26
12
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
17.8
614
4327
T72
ICPC
Benign neoplasm thyroid
14.6
17.6
29
20
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
6.2
17.2
29
47
BA1NN
NOMESCO Finland
I-131 dose capsel measurement
+∞
16.7
16
*
1930A
ICD-9 Finland
Malignant neoplasm of thyroid gland[CARCINOMA PAPILLARE THYREOIDEAE]
+∞
16.7
16
*
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
3.9
16.4
48
125
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
3.7
16.3
50
135
R51.80
ICD-10 Finland
Headache
1.6
16.2
478
3253
M54.5
ICD-10 Finland
Low back pain
1.4
16.0
1095
8748
T85
ICPC
Hyperthyroidism/thyrotoxicosis
21.1
16.0
23
11
A06AC01
ATC
ispaghula (psylla seeds); oral
1.4
15.8
800
6063
Z00.0
ICD-10 Finland
General medical examination
1.5
15.7
549
3872
R01AD09
ATC
mometasone; nasal
1.4
15.4
1351
11210
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
15.1
714
5337
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.5
15.1
554
3944
SPAT1263
SPAT
Sampling
1.4
15.0
1170
9520
R03AC02
ATC
salbutamol; inhalant
1.4
15.0
1618
13843
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
1.7
14.9
265
1586
R52.9
ICD-10 Finland
Pain, unspecified
1.7
14.8
313
1962
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
3.2
14.7
58
185
Z01.2
ICD-10 Finland
Dental examination
1.4
14.6
1378
11535
BWD00
NOMESCO Finland
Reoperation for deep haemorrhage in endocrine surgery
+∞
14.6
14
*
2419X
ICD-9 Finland
Non-toxic nodular goitre, Unspecified non-toxic nodular goitre
+∞
14.6
14
*
M01AE02
ATC
naproxen; oral, rectal
1.3
14.5
1654
14241
R42
ICD-10 Finland
Dizziness and giddiness
1.4
14.5
675
5029
A11CC03
ATC
alfacalcidol; systemic
3.0
14.4
63
213
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
3.8
14.4
43
114
A02BC02
ATC
pantoprazole; systemic
1.4
14.3
2045
18202
ZX114
NOMESCO Finland
Intramuscular
3.7
14.3
44
119
R49.8
ICD-10 Finland
Other and unspecified voice disturbances
3.5
14.3
48
138
BA3AT, ,
SPAT
14.5
14.0
23
16
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
3.5
13.9
47
136
G47.3
ICD-10 Finland
Sleep apnoea
1.5
13.6
561
4077
J01DB01
ATC
cefalexin; oral
1.4
13.6
2445
22477
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
13.5
13
*
8340/3-C73.9
ICD-O-3
Papillary carcinoma, follicular variant of thyroid gland
+∞
13.5
13
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
13.5
13
*
ZSB00
NOMESCO Finland
Procedure related to previous procedure classified in chapter B
34.2
13.5
17
5
J01FA10
ATC
azithromycin; systemic
1.3
13.4
1674
14534
R07.0
ICD-10 Finland
Pain in throat
1.8
13.4
204
1168
R53
ICD-10 Finland
Malaise and fatigue
1.4
13.3
698
5299
S04
ICPC
Lump/swelling localized
1.6
13.3
334
2184
WZC00
NOMESCO Finland
Treatment plan or consultation
1.3
13.2
1069
8705
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.5
13.1
392
2668
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
1.7
13.0
263
1629
UKC02
NOMESCO Finland
Cystoscopy
1.6
13.0
358
2391
L03
ICPC
Low back symptom/complaint
1.4
13.0
872
6893
C07AA05
ATC
propranolol; systemic
1.4
12.9
561
4117
A11CC02
ATC
dihydrotachysterol; oral
22.6
12.9
18
8
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.6
12.8
282
1785
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
1.8
12.8
181
1012
UJF32
NOMESCO Finland
Coloscopy
1.4
12.6
728
5611
WZC30
NOMESCO Finland
Teaching
1.5
12.6
465
3306
8341/3-C73.9
ICD-O-3
Papillary microcarcinoma of thyroid gland
+∞
12.5
12
*
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
12.5
12
*
2411A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic multinodular goitre
+∞
12.5
12
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
12.5
517
3757
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
130.5
12.4
13
*
R01AD08
ATC
fluticasone; nasal
1.4
12.4
819
6453
R21
ICPC
Throat symptom/complaint
1.4
12.2
579
4310
C05AA08
ATC
fluocortolone; rectal, topical
1.5
12.1
378
2596
G44.2
ICD-10 Finland
Tension-type headache
1.5
12.1
411
2873
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
12.0
1475
12693
J01FA09
ATC
clarithromycin; systemic
1.3
11.9
887
7108
Z50.5
ICD-10 Finland
Speech therapy
3.4
11.9
42
125
XKD00
NOMESCO Finland
Uroflowmetry
1.6
11.9
270
1722
M25.5
ICD-10 Finland
Pain in joint
1.3
11.8
989
8061
A77
ICPC
Viral disease other/NOS
2.2
11.8
99
460
E83.51
ICD-10 Finland
Hypocalcemia
5.4
11.8
23
43
J01AA02
ATC
doxycycline; systemic
1.4
11.6
2314
21250
M79.6
ICD-10 Finland
Pain in limb
1.3
11.6
1318
11205
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
1.8
11.5
171
972
WX402
NOMESCO Finland
General anaesthesia
1.4
11.5
629
4799
GB1AA
NOMESCO Finland
Tracheal X-ray examination
120.5
11.4
12
*
R4110, ,
SPAT
1.5
11.4
411
2903
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.4
11.4
605
4588
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.6
11.2
252
1604
K30
ICD-10 Finland
Functional dyspepsia
1.5
11.1
338
2307
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.3
10.9
1660
14617
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.3
10.9
1297
11063
R06.0
ICD-10 Finland
Dyspnoea
1.4
10.8
730
5748
D17.1
ICD-10 Finland
Benign lipomatous neoplasm of skin and subcutaneous tissue of trunk
2.1
10.8
101
491
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
10.8
1154
9705
ZXA05
NOMESCO Finland
Left side
1.4
10.6
651
5051
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
10.5
2094
19060
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.6
10.5
243
1559
8290/3-C73.9
ICD-O-3
Oxyphilic adenocarcinoma of thyroid gland
+∞
10.4
10
*
2260A
ICD-9 Finland
Benign neoplasm of thyroid gland[NEOPLASMA BENIGNUM GLANDULAE THYREOIDEAE]
+∞
10.4
10
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.3
10.4
964
7942
L01
ICPC
Neck symptom/complaint
1.4
10.3
487
3614
D25.9
ICD-10 Finland
Leiomyoma of uterus, unspecified
1.5
10.3
286
1911
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.5
10.3
382
2712
J02AC01
ATC
fluconazole; systemic
1.3
10.3
1237
10543
ZXA00
NOMESCO Finland
Right side
1.3
10.2
700
5520
A02BC04
ATC
rabeprazole; oral
1.6
10.0
254
1663
M54.4
ICD-10 Finland
Lumbago with sciatica
1.4
10.0
518
3906
R01AD12
ATC
fluticasone furoate; nasal
1.3
9.9
881
7210
SPAT1153
SPAT
Removal of sutures
1.3
9.8
836
6795
C07AB07
ATC
bisoprolol; oral
1.3
9.8
1273
10932
N03AX16
ATC
[U] pregabalin
1.4
9.7
623
4857
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.3
9.7
876
7177
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.3
9.6
801
6490
A12AA04
ATC
calcium carbonate; oral
3.0
9.5
40
133
SPAT1312
SPAT
General health counselling
1.3
9.5
838
6842
M03BX02
ATC
tizanidine; oral
1.3
9.5
1795
16115
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.3
9.4
721
5768
SPAT1249
SPAT
Treatment-related counselling outside office
1.3
9.4
1054
8876
R00.2
ICD-10 Finland
Palpitations
1.6
9.4
233
1519
UJF30
NOMESCO Finland
Ileoscopy through colon
1.5
9.4
292
2001
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
+∞
9.4
9
*
M01AH05
ATC
etoricoxib; oral
1.3
9.3
1825
16432
A98
ICPC
Health maint/preventive medicine
1.9
9.3
2985
28986
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.6
9.3
218
1403
EP2AT
NOMESCO Finland
Neck soft tissue cytology with ultrasound guidance
10.7
9.3
17
16
M79.0
ICD-10 Finland
Rheumatism, unspecified
1.9
9.3
107
562
K11.2
ICD-10 Finland
Sialoadenitis
2.0
9.2
92
460
A02BC01
ATC
omeprazole; systemic
1.3
9.2
728
5854
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
9.1
1401
12245
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
1.6
9.1
189
1180
BB1BQ
NOMESCO Finland
Extensive scintigraphy of parathyroid gland, 2 isotopes, SPECT and low-dose CT
4.4
9.1
22
50
P01AB01
ATC
metronidazole; oral, rectal
1.3
9.0
1174
10063
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.4
8.8
355
2560
DFF00
NOMESCO Finland
Pure tone audiometry
1.5
8.8
276
1895
M70.6
ICD-10 Finland
Trochanteric bursitis
1.4
8.7
424
3158
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
8.7
1092
9301
R12
ICD-10 Finland
Heartburn
1.5
8.6
238
1590
S18
ICPC
Laceration/cut
1.3
8.6
1303
11349
L15
ICPC
Knee symptom/complaint
1.3
8.5
746
6068
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
16.3
8.5
13
8
T15
ICPC
THYROID LUMP/MASS
20.1
8.5
12
6
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
1.7
8.4
152
916
R05
ICD-10 Finland
Cough
1.3
8.4
600
4749
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
1.6
8.3
180
1135
E05.4
ICD-10 Finland
Thyrotoxicosis factitia
+∞
8.3
8
*
C739, ,
ICD-10 Finland
+∞
8.3
8
*
24110
ICD-8 Finland
Non-toxic nodular goitre, Sporadic
+∞
8.3
8
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.3
8.3
611
4850
SPAT1310
SPAT
Counselling related to known health issue
1.3
8.2
829
6867
SPAT1211
SPAT
Application of soft bandage
1.5
8.2
223
1485
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
4.2
8.2
21
50
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
8.1
762
6250
J01EA01
ATC
trimethoprim; systemic
1.3
8.1
768
6307
L72.1
ICD-10 Finland
Trichilemmal cyst
1.6
8.1
179
1136
SPAT1375
SPAT
Structural ultrasound screening, weeks 18+0-21+6
3.5
8.1
27
78
EP1AT
NOMESCO Finland
Punction of soft tissue of neck with ultrasound guidance
33.4
8.1
10
*
E06
ICD-10 Finland
Thyroiditis
22.1
8.0
11
5
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
1.9
8.0
94
498
XA402
NOMESCO Finland
ENMG
2.1
7.9
70
334
C07AB02
ATC
metoprolol; systemic
1.4
7.9
463
3555
UDH02
NOMESCO Finland
Rhinopharyngoscopy
1.6
7.9
170
1073
R20.2
ICD-10 Finland
Paraesthesia of skin
1.6
7.9
187
1208
R49.03
ICD-10 Finland
Atrophic dysphonia
2.9
7.8
35
121
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.4
7.8
368
2725
J05AB01
ATC
aciclovir; systemic
1.3
7.8
625
5017
UDC00
NOMESCO Finland
Ear microscopy
1.6
7.8
181
1162
-60
ICPC
Result test/procedure
1.7
7.8
145
882
N06AX11
ATC
mirtazapine; oral
1.3
7.8
924
7800
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
2.5
7.7
47
191
E21.0
ICD-10 Finland
Primary hyperparathyroidism
2.2
7.7
61
279
K07.60
ICD-10 Finland
Snapping jaw
1.6
7.7
154
954
SAA02
NOMESCO Finland
Basic examination of mouth
1.2
7.7
1911
17489
H43.8
ICD-10 Finland
Other disorders of vitreous body
1.4
7.7
285
2024
J30.0
ICD-10 Finland
Vasomotor rhinitis
2.0
7.6
75
373
SPAT1058
SPAT
PEF monitoring instruction
1.5
7.6
211
1411
TEA00
NOMESCO Finland
Biopsy of lip
3.0
7.6
32
107
L13
ICPC
Hip symptom/complaint
1.3
7.6
578
4608
A04
ICPC
Weakness/tiredness general
1.4
7.6
409
3099
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
1.7
7.5
139
843
H02AB06
ATC
prednisolone; systemic
1.2
7.5
1291
11348
OAB50
NOMESCO Finland
Delivery of care equipment and instruction on their use
2.9
7.5
34
119
R01AD58
ATC
fluticasone, combinations; nasal
1.3
7.5
682
5568
J01DA01
ATC
[U] cefalexin
1.2
7.4
1713
15521
M01AB05
ATC
diclofenac; systemic, rectal
1.2
7.4
1875
17153
R03BA05
ATC
fluticasone; inhalant
1.3
7.4
470
3652
M01AE03
ATC
ketoprofen; systemic, rectal
1.3
7.3
962
8203
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.3
7.2
694
5701
A02BC03
ATC
lansoprazole; oral
1.3
7.2
753
6249
L82
ICD-10 Finland
Seborrhoeic keratosis
1.3
7.2
536
4258
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
1.6
7.1
181
1187
A29
ICPC
General symptom/complaint other
1.4
7.1
351
2618
XX9KE
NOMESCO Finland
Ultrasound examination with contrast
12.0
7.1
12
10
R05
ICPC
Cough
1.3
7.1
707
5834
R29
ICPC
Respiratory symptom/complaint other
1.6
7.0
179
1175
G04CB01
ATC
finasteride; oral
1.6
7.0
142
882
R4130
NOMESCO Finland
Speech therapy
2.1
7.0
65
317
N02BF02
ATC
pregabalin; oral
1.5
7.0
181
1194
C09CA06
ATC
candesartan; oral
1.3
7.0
660
5408
H25.8
ICD-10 Finland
Other senile cataract
1.4
6.9
273
1959
Z85.8
ICD-10 Finland
Personal history of malignant neoplasms of other organs and systems
13.8
6.9
11
8
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.2
6.9
1257
11085
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
2.0
6.9
74
381
DAX08
NOMESCO Finland
Fitting of hearing aid
1.6
6.9
140
872
K64.9
ICD-10 Finland
Haemorrhoids, unspecified
1.7
6.9
113
665
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
2.1
6.8
59
280
PH2DE
NOMESCO Finland
Ultrasound examination of bloodflow in veins of lower extremity with Doppler method
1.9
6.8
78
411
R4135
NOMESCO Finland
Rehabilitation for hearing problems
2.3
6.8
48
210
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
6.1
6.8
17
28
XX1AT
NOMESCO Finland
Other puncture with ultrasound guidance
2.5
6.8
41
167
K08.80
ICD-10 Finland
Toothache NOS
1.5
6.8
243
1715
2502
FHL
Thyroid exploration and possible biopsy
40.1
6.8
8
*
C08CA05
ATC
nifedipine; systemic
1.6
6.8
135
837
H33.3
ICD-10 Finland
Retinal breaks without detachment
1.8
6.7
89
491
EB1VA, ,
NOMESCO Finland
1.3
6.7
488
3861
J01FA06
ATC
roxithromycin; oral
1.2
6.7
1082
9413
N40
ICD-10 Finland
Hyperplasia of prostate
1.4
6.7
283
2058
A12AA06
ATC
calcium lactate gluconate; oral
22.6
6.7
9
*
SFA20
NOMESCO Finland
Two-surface restoration
1.2
6.7
1637
14854
H04.10
ICD-10 Finland
Dry eye syndrome
1.4
6.6
339
2544
ELB30
NOMESCO Finland
Excision of submandibular gland
3.7
6.6
20
54
A02BA02
ATC
ranitidine; systemic
1.3
6.6
474
3741
J01CA04
ATC
amoxicillin; systemic
1.3
6.6
2368
22333
I47.9
ICD-10 Finland
Paroxysmal tachycardia, unspecified
2.2
6.6
52
238
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.4
6.6
299
2200
L57.0
ICD-10 Finland
Actinic keratosis
1.4
6.6
270
1954
R03DC03
ATC
montelukast; oral
1.3
6.5
450
3532
M79.7
ICD-10 Finland
Fibromyalgia
1.7
6.5
103
599
M01AH01
ATC
celecoxib; oral
1.3
6.5
476
3772
JN3AE, ,
SPAT
1.7
6.5
106
624
EB4VA, ,
NOMESCO Finland
1.3
6.4
474
3755
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.2
6.4
1332
11870
I10
ICD-10 Finland
Essential (primary) hypertension
1.2
6.4
1642
14933
J45.9
ICD-10 Finland
Asthma, unspecified
1.3
6.4
508
4065
R51
ICD-10 Finland
Headache
1.6
6.4
145
928
R01BA52
ATC
pseudoephedrine, combinations; oral
1.2
6.4
838
7126
D24
ICD-10 Finland
Benign neoplasm of breast
2.0
6.3
64
323
G25.8
ICD-10 Finland
Other specified extrapyramidal and movement disorders
1.9
6.3
80
436
WZC30, ,
SPAT
1.5
6.3
225
1587
Z01.7
ICD-10 Finland
Laboratory examination
1.3
6.3
448
3535
62630
ICD-8 Finland
Disorders of menstruation, Painful
2.8
6.3
29
103
R02
ICPC
Shortness of breath/dyspnoea
1.4
6.3
345
2621
EP2LT
NOMESCO Finland
Coagulation of neck area under radiological guidance
+∞
6.3
6
*
E03.8
ICD-10 Finland
Other specified hypothyroidism
+∞
6.3
6
*
HMAK, ,
NOMESCO Finland
1.4
6.2
292
2160
N02AX02
ATC
tramadol; systemic, rectal
1.2
6.2
1122
9853
E23.05
ICD-10 Finland
Lack of TSH
26.7
6.2
8
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.6
6.2
149
966
J01MA02
ATC
ciprofloxacin; systemic
1.2
6.2
978
8471
M54.6
ICD-10 Finland
Pain in thoracic spine
1.5
6.2
201
1391
N64.4
ICD-10 Finland
Mastodynia
1.7
6.2
101
594
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.3
6.2
449
3550
SFA10
NOMESCO Finland
One-surface restoration
1.2
6.1
1520
13758
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
1.6
6.1
146
946
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.3
6.1
600
4932
G43.9
ICD-10 Finland
Migraine, unspecified
1.5
6.1
156
1027
M53.1
ICD-10 Finland
Cervicobrachial syndrome
1.4
6.1
320
2413
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
1.7
6.1
99
582
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
1.3
6.1
388
3014
SPAT1097
SPAT
Recording of ECG
1.4
6.0
341
2600
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
1.7
6.0
115
706
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
564
626
10.80
307.65
1.5
1.2
—
—
—
0
0
570
935
7.25
307.65
4.3
1.7
4.55
4.44
pmol/l
1.82
522
832
198
74
28.52
292.34
7.4
1.2
143.30
281.52
u/ml
—
71
8
2821
21309
4.71
148.90
7.7
2.8
15.34
14.43
pmol/l
65.74
2679
19483
201
327
6.50
119.02
1.6
1.2
3.27
1.88
iu/l
1.32
58
84
433
1447
3.32
102.67
1.3
1.2
90.03
70.01
u/ml
0.59
145
454
1993
14089
2.17
88.65
7.2
6.7
1.22
1.22
mmol/l
0.14
1728
12178
2933
25426
4.00
71.49
9.3
4.0
1.88
1.89
mu/l
0.06
2788
23539
1727
12578
1.85
58.87
6.2
6.1
1.22
1.22
mmol/l
0.28
1603
11609
432
2081
2.25
47.81
3.0
3.7
66.91
88.84
ng/l
7.61
355
1785
2450
20732
1.88
42.92
5.0
4.5
11.08
12.48
mm/h
6.30
2295
19419
1699
13425
1.59
33.96
2.7
2.4
81.28
78.82
nmol/l
3.10
1549
12179
563
3400
1.80
31.87
5.3
4.9
33.24
32.98
%
0.22
403
2198
2428
21418
1.62
26.01
8.7
8.3
76.42
78.71
u/l
2.07
2318
20309
1306
10126
1.50
25.67
4.0
3.6
27.31
97.50
ng/l
0.87
879
6840
2829
26118
1.98
24.81
17.0
15.0
80.10
80.98
ml/min/173m2
1.63
2662
24127
2896
26976
2.17
24.55
16.8
15.4
18.75
23.60
mg/l
15.38
2466
22103
1632
13325
1.48
24.28
2.6
2.7
—
—
estimate
—
0
0
1615
13236
1.46
23.07
6.2
6.4
56.48
57.33
%
2.40
1533
12640
373
2209
1.78
22.00
4.4
3.6
1.23
1.23
mmol/l
0.08
340
1908
417
2557
1.73
21.77
2.3
2.1
371.05
379.84
nmol/l
0.38
384
2368
1625
13460
1.44
21.15
6.3
6.5
28.75
27.93
%
2.56
1541
12769
1274
10117
1.44
20.72
3.0
3.5
2.35
2.36
mmol/l
5.60
1149
9170
2922
27581
2.09
19.53
19.3
17.7
139.93
139.71
mmol/l
5.48
2874
27056
2743
25409
1.71
19.28
4.7
4.1
1.26
1.25
mmol/l
0.52
2515
23376
2923
27629
2.07
18.90
19.4
17.9
3.94
3.95
mmol/l
2.56
2872
27035
1508
12486
1.41
18.73
11.6
13.7
1.19
1.22
inr
1.45
1272
10263
1025
7950
1.43
18.36
4.0
3.4
0.97
0.14
estimate
0.57
344
2388
2806
26223
1.76
18.21
5.7
5.0
5.85
5.85
mmol/l
0.03
2589
24126
1732
14752
1.40
17.84
6.4
6.5
0.19
0.19
e9/l
0.09
1544
12841
1865
16091
1.40
17.76
4.4
4.7
6.47
6.58
mmol/l
2.10
1788
15198
1125
8924
1.41
17.56
2.7
2.6
55.62
70.59
u/l
1.01
1054
8285
2842
26729
1.79
17.05
5.6
4.9
1.52
1.55
mmol/l
2.27
2635
24848
2854
26875
1.81
17.05
5.7
5.0
4.73
4.76
mmol/l
0.95
2663
25147
1707
14570
1.38
16.96
6.4
6.4
1.85
1.91
e9/l
1.34
1540
12787
1674
14258
1.38
16.76
6.3
6.4
0.56
0.57
e9/l
0.68
1484
12190
1677
14294
1.38
16.68
6.2
6.4
0.04
0.04
e9/l
0.13
1483
12221
1015
7969
1.41
16.58
3.4
3.0
1043.69
1141.30
ng/l
0.46
868
6860
1082
8589
1.40
16.57
2.1
2.1
145.84
195.39
u/l
2.54
1017
8112
761
5701
1.44
16.06
1.4
1.3
22.21
31.47
iu/ml
3.03
234
1746
712
5297
1.45
15.52
1.3
1.3
6.97
11.08
u/ml
1.36
289
2056
2070
18399
1.38
15.06
3.4
3.2
41.40
45.19
u/l
1.69
1929
17253
2876
27268
1.79
15.04
6.3
5.7
2.77
2.77
mmol/l
0.02
2669
25408
1723
14903
1.35
14.78
6.2
6.6
10.41
10.89
umol/l
1.39
1627
14218
2723
25493
1.57
14.56
6.8
6.0
38.83
38.76
mmol/mol
0.16
2539
23853
894
7075
1.37
13.29
2.3
2.3
—
—
—
0
0
2979
28677
2.07
13.18
22.6
19.9
73.85
72.73
umol/l
1.59
2958
28345
339
2237
1.58
12.99
2.5
2.4
0.34
0.50
e6/l
1.02
320
2126
77
308
2.54
12.86
1.2
1.2
—
31.00
—
0
5
2963
28498
1.96
12.70
13.5
12.1
24.19
24.49
u/l
0.55
2881
27690
263
1652
1.65
12.33
2.9
3.6
5.08
5.17
kpa
1.11
251
1584
1825
16142
1.32
12.29
9.4
9.8
3.88
4.04
e9/l
2.60
1627
13981
127
644
2.01
12.06
3.5
2.9
1.41
1.56
mmol/l
1.15
127
629
1323
11218
1.31
12.00
4.4
3.9
1.78
0.28
estimate
0.49
342
2456
3024
29362
2.38
11.70
27.1
23.6
134.36
133.04
g/l
7.04
3008
29068
3023
29351
2.36
11.65
27.0
23.5
257.68
258.32
e9/l
0.22
2986
28782
3023
29352
2.36
11.63
26.8
23.4
90.90
91.19
fl
3.38
3007
29057
3023
29355
2.35
11.57
27.2
23.9
40.05
39.96
%
0.21
3005
29039
3023
29356
2.35
11.55
26.9
23.5
4.48
4.43
e12/l
9.29
2976
28686
3023
29356
2.35
11.55
26.9
23.5
6.51
6.66
e9/l
3.66
2977
28673
106
511
2.11
11.54
2.3
1.9
5.62
4.93
mmol/24h
1.01
89
448
111
546
2.07
11.46
3.7
3.0
6.97
7.47
mmol/l
1.18
111
534
850
6812
1.34
11.30
1.3
1.3
0.92
1.60
u/ml
2.72
232
1800
1445
12478
1.30
11.16
12.3
11.1
0.00
0.00
e9/l
1.02
1234
10097
1695
14947
1.30
11.14
4.5
4.0
0.00
0.00
estimate
1.08
410
3004
1725
15247
1.30
11.14
4.5
4.0
0.01
0.11
estimate
0.48
410
2959
232
1470
1.63
10.51
4.0
3.4
1.02
1.02
ratio
0.09
216
1327
1532
13437
1.28
10.06
3.5
3.0
109.10
110.21
ug/l
0.08
1430
12588
1698
15111
1.27
9.79
4.6
4.0
0.00
4.06
estimate
2.25
426
3103
60
246
2.47
9.61
1.3
1.2
72.50
61.73
u/ml
—
6
11
706
5622
1.33
9.56
1.7
1.7
39441976.90
44769245.99
pmol/l
0.07
573
4693
151
875
1.76
9.56
2.2
2.8
24.35
24.92
mmol/l
1.03
151
860
974
8107
1.29
9.55
1.7
1.7
20.57
20.76
nmol/l
0.16
824
6784
1062
8965
1.28
9.26
4.3
4.0
9.79
8.24
mg/mmol
0.32
606
5266
1429
12523
1.26
9.09
2.2
2.1
101.31
97.21
pmol/l
2.31
749
6278
500
3807
1.37
9.04
2.3
2.3
104.24
112.92
ug/g
0.33
375
3012
973
8164
1.28
8.80
4.4
4.2
0.00
0.00
estimate
1.74
381
2838
1094
9323
1.27
8.69
3.4
3.3
6.88
7.02
mmol/l
0.50
924
7845
148
879
1.72
8.62
2.9
3.9
24.85
25.02
mmol/l
0.30
134
810
1440
12695
1.25
8.48
4.4
4.9
36.25
35.74
g/l
3.23
1357
11928
212
1390
1.56
8.34
2.7
3.5
1.68
1.99
mmol/l
0.63
146
1051
464
3549
1.36
8.10
5.4
5.4
1.03
1.04
mmol/l
0.29
423
3279
583
4629
1.32
7.90
3.2
3.2
0.82
0.81
mmol/l
1.69
547
4358
151
924
1.67
7.89
1.4
1.3
23.86
34.93
u/ml
—
10
46
717
5866
1.29
7.76
1.5
1.5
2.20
2.39
g/l
2.18
460
3551
142
859
1.68
7.76
1.4
1.3
2.75
7.13
u/ml
1.43
28
139
57
254
2.27
7.65
1.6
1.6
413.51
330.35
mu/l
0.40
49
204
141
858
1.67
7.54
1.4
1.3
2.17
6.57
u/ml
0.62
16
84
284
2026
1.44
7.45
2.4
2.4
18.21
22.46
au/ml
0.47
22
206
263
1854
1.46
7.34
1.3
1.3
21.47
51.50
au/ml
—
10
128
854
7199
1.26
7.15
2.4
2.3
2.78
2.83
mg/l
0.33
746
6239
547
4371
1.31
7.01
1.7
1.7
1042.79
1177.40
nmol/l
2.95
422
3311
205
1390
1.51
6.96
2.4
2.3
0.02
0.57
estimate
0.48
57
440
79
416
1.92
6.88
1.3
1.3
23.86
30.15
u/l
0.81
65
344
163
1057
1.57
6.78
1.9
1.9
—
—
—
0
0
79
423
1.89
6.56
1.4
1.4
—
—
—
0
0
117
705
1.69
6.54
1.4
1.3
1.13
3.63
u/ml
—
10
49
760
6393
1.25
6.37
2.2
1.7
0.93
1.15
mg/l
1.89
601
4972
170
1135
1.53
6.23
1.6
1.6
10.38
15.05
u/ml
0.66
31
271
2006
18664
1.21
5.98
5.4
4.8
5931.14
2193.00
e6/l
0.44
22
228
93
544
1.73
5.83
1.3
1.3
12.84
13.11
u/l
0.06
79
443
187
1294
1.47
5.79
4.5
3.8
43.95
47.23
%
1.15
187
1274
66
351
1.90
5.65
1.6
1.5
—
—
—
0
0
54
272
2.00
5.42
1.3
1.3
—
—
—
0
0
66
357
1.87
5.38
1.7
1.5
—
—
—
0
0
65
351
1.87
5.33
1.6
1.5
—
—
—
0
0
171
1188
1.47
5.21
1.8
2.0
39.55
40.51
u/l
0.29
155
1068
943
8269
1.20
5.08
3.5
3.0
0.05
0.05
0.05
39
198
77
446
1.75
5.04
1.3
1.3
0.22
0.41
nmol/l
—
5
23
312
2415
1.32
5.00
3.8
3.4
0.87
0.77
ug/l
0.51
223
1628
143
969
1.50
4.95
1.7
1.8
—
—
—
0
0
312
2420
1.32
4.93
2.0
2.0
—
—
—
0
0
67
376
1.80
4.89
1.3
1.3
0.45
0.18
nmol/l
0.45
50
300
2161
22727
0.84
4.77
21.2
19.7
331.51
331.24
g/l
0.62
2151
22613
180
1286
1.42
4.75
2.0
2.0
9.33
7.49
iu/ml
0.33
49
311
154
1069
1.46
4.74
2.2
2.2
12.62
11.97
nmol/l
0.38
132
951
48
244
1.98
4.74
1.3
1.2
108.58
113.13
pmol/l
0.27
48
244
141
964
1.48
4.69
2.2
2.1
4247.57
5277.75
u/l
0.22
47
395
255
1935
1.35
4.69
1.2
1.3
102.60
196.22
u/ml
4.41
230
1804
128
858
1.51
4.68
1.3
1.4
323.29
285.23
ug/g
1.36
68
492
58
316
1.85
4.67
1.4
2.1
24.61
24.09
mg/l
0.02
12
109
515
4283
1.24
4.66
2.7
2.5
2.40
2.34
g/l
1.93
478
3964
26
103
2.54
4.62
1.9
1.3
133.50
75.17
nmol/24h
0.41
26
103
60
333
1.82
4.57
1.7
1.5
—
—
—
0
0
60
334
1.81
4.52
1.7
1.5
—
—
—
0
0
60
334
1.81
4.52
1.7
1.5
—
—
—
0
0
1016
9063
1.18
4.38
3.7
3.3
23.41
64.10
e6/l
3.65
807
6771
547
4617
1.22
4.29
2.7
2.5
13.22
13.10
umol/l
0.15
511
4304
292
2295
1.30
4.21
2.3
2.7
66.74
66.52
g/l
0.21
264
2110
168
1216
1.40
4.16
1.3
1.3
0.22
0.99
u/ml
1.68
13
98
597
5100
1.21
4.14
1.6
1.5
—
—
—
0
0
336
2705
1.27
4.02
2.0
2.1
—
—
—
0
0
31
145
2.15
3.86
2.1
1.6
4.22
3.87
nmol/l
0.06
24
117
18
66
2.74
3.75
1.2
1.1
—
—
—
0
0
203
1554
1.33
3.57
1.4
1.3
30.15
31.39
iu/l
0.19
178
1351
26
119
2.19
3.44
1.7
1.8
—
—
—
0
0
464
3937
1.21
3.44
2.8
2.5
22.27
22.51
%
0.16
436
3659
782
6947
1.17
3.41
2.6
2.5
323.31
326.79
umol/l
0.47
681
6136
138
1007
1.39
3.32
1.8
1.7
—
—
—
0
0
198
1531
1.31
3.27
1.1
1.1
—
—
—
0
0
476
4069
1.20
3.26
6.4
5.7
2.59
2.80
ug/l
0.26
424
3647
13
39
3.34
3.22
1.2
1.1
—
—
—
0
0
1287
11892
1.14
3.21
2.0
1.9
1.34
1.32
mmol/l
0.38
1050
10023
310
2544
1.24
3.18
4.1
3.6
1.83
1.96
mmol/l
0.33
283
2242
84
567
1.49
3.09
3.2
3.4
23.72
26.59
mg/l
0.25
47
396
118
850
1.40
3.09
1.3
1.3
—
—
—
0
0
38
209
1.83
3.08
2.1
2.0
1.60
1.70
u/field
0.05
20
105
29
146
2.00
3.04
1.6
1.3
—
—
—
0
0
10
280
0.36
2.94
1.3
1.2
—
—
—
0
0
261
2123
1.25
2.91
2.9
4.0
96.82
64.77
u/ml
0.29
252
2059
24
115
2.10
2.88
1.0
1.3
157.07
148.03
mmol/24h
0.26
24
115
1141
10519
1.13
2.86
4.5
3.9
95.31
103.02
e6/l
0.14
853
7166
62
401
1.56
2.80
1.6
1.3
312.92
305.46
pmol/l
0.06
55
349
35
196
1.79
2.71
1.8
1.6
97.66
97.76
ng/l
0.00
35
196
382
3256
1.20
2.71
5.0
4.7
21.56
21.32
%
0.13
210
1636
178
1395
1.29
2.71
2.9
2.8
1.04
1.20
%
1.65
178
1386
24
118
2.04
2.71
1.7
1.4
—
—
—
0
0
24
118
2.04
2.71
1.7
1.4
—
—
—
0
0
1795
17047
1.13
2.71
3.0
3.0
—
—
—
0
0
1073
9882
1.13
2.70
3.7
3.3
—
1.62
—
0
7
177
1389
1.29
2.67
2.8
2.8
0.62
0.62
%
0.04
177
1383
699
6267
1.15
2.64
3.0
2.7
6.86
6.64
e6/l
0.07
642
5661
359
3068
1.19
2.49
5.5
4.4
233.47
246.76
u/l
1.01
337
2912
11
37
2.98
2.48
1.6
2.1
—
—
—
0
0
121
912
1.34
2.46
2.1
1.8
0.23
0.23
g/l
0.12
112
866
326
2768
1.20
2.43
3.0
3.3
—
—
—
0
0
124
940
1.33
2.43
2.0
1.8
1.16
1.19
g/l
0.66
114
895
17
77
2.21
2.37
1.1
1.1
4.34
11.38
u/ml
1.55
11
57
150
1177
1.29
2.31
2.4
2.3
3.52
3.74
g/l
0.92
140
1078
96
706
1.37
2.30
1.4
1.2
34.45
46.58
u/ml
—
10
84
23
119
1.94
2.30
2.1
2.5
—
—
—
0
0
504
4460
1.16
2.28
3.2
2.9
3.35
3.31
e6/l
0.03
293
2076
117
889
1.33
2.28
1.4
1.3
—
—
—
0
0
142
1110
1.29
2.26
2.5
2.3
2.76
2.92
g/l
1.28
133
1011
364
3146
1.18
2.23
3.7
4.2
20.90
18.36
ug/l
0.10
282
2522
1025
9505
1.12
2.22
3.0
3.3
31.82
32.58
u/l
0.14
968
8983
149
1176
1.28
2.20
2.4
2.3
4.25
4.23
g/l
0.07
140
1076
11
41
2.69
2.20
1.6
2.0
—
—
—
0
0
149
1177
1.28
2.19
2.4
2.3
7.19
7.46
g/l
1.33
140
1078
22
116
1.90
2.10
2.6
2.4
21.11
86.78
ug/l
0.49
22
105
272
2305
1.20
2.10
2.3
2.7
69.70
70.10
e9/l
0.07
211
1649
257
2168
1.20
2.08
3.0
2.8
10.27
10.48
g/l
0.38
235
2012
30
176
1.71
2.05
1.6
1.3
—
—
—
0
0
20
103
1.95
2.05
2.2
1.7
—
—
—
0
0
20
104
1.93
2.00
2.2
1.7
—
—
—
0
0
20
104
1.93
2.00
2.2
1.7
—
—
—
0
0
246
2076
1.20
2.00
1.7
1.7
—
—
—
0
0
19
98
1.94
1.95
1.5
1.6
0.52
0.35
ug/l
0.84
14
70
29
172
1.69
1.93
1.6
1.3
—
—
—
0
0
39
251
1.56
1.89
2.8
2.7
—
—
—
0
0
80
595
1.35
1.85
2.5
2.9
8.25
8.18
kpa
0.16
80
581
128
1018
1.27
1.83
2.5
2.3
1.00
0.92
g/l
0.09
114
879
69
503
1.38
1.81
1.0
1.1
4.76
4.21
u/ml
0.08
38
258
36
547
0.65
1.78
3.5
6.3
105.65
105.14
mmol/l
0.36
31
487
96
739
1.31
1.77
2.0
2.2
11.43
11.85
mg/l
0.20
86
684
110
863
1.28
1.76
1.6
1.3
—
—
—
0
0
5
13
3.85
1.71
1.2
1.3
199.00
312.08
u/l
—
5
13
25
148
1.69
1.70
2.7
3.0
1046.56
899.58
u/ml
0.18
25
148
14
68
2.06
1.70
1.1
1.2
180.42
147.89
pmol/l
0.47
14
68
15
75
2.00
1.69
1.3
1.1
—
—
—
0
0
846
7867
1.10
1.68
3.6
3.2
0.33
0.43
e6/l
0.97
652
5638
115
919
1.26
1.61
1.4
1.3
245.47
225.14
miu/ml
0.26
58
439
109
866
1.27
1.61
2.8
2.3
0.03
0.01
g/l
0.23
99
781
508
4608
1.12
1.60
1.9
1.9
—
—
—
0
0
543
4948
1.12
1.58
3.0
2.8
0.94
1.32
e6/l
1.55
333
2562
240
2069
1.17
1.58
2.1
2.3
6.59
6.72
ug/l
0.04
205
1815
25
399
0.62
1.58
1.4
1.5
60.95
58.37
ug/l
0.15
25
399
464
4191
1.13
1.57
2.5
2.0
29.05
29.33
s
0.61
453
4062
43
297
1.45
1.55
1.7
2.0
74.45
23.78
ug/l
0.43
43
292
636
5854
1.11
1.54
2.9
3.0
2.44
2.46
mmol/l
3.19
582
5284
5
15
3.34
1.52
1.0
1.0
8.20
8.45
%
—
5
15
5
15
3.34
1.52
1.0
1.0
33.46
37.11
%
—
5
15
6
21
2.86
1.50
1.0
1.0
—
—
—
0
0
42
291
1.45
1.50
1.3
1.2
—
—
—
0
0
117
947
1.24
1.49
1.7
1.5
1.44
7.51
iu/ml
0.39
21
167
22
131
1.68
1.49
2.2
1.6
—
—
—
0
0
22
131
1.68
1.49
2.2
1.6
—
—
—
0
0
22
131
1.68
1.49
2.2
1.6
—
—
—
0
0
22
131
1.68
1.49
2.2
1.6
—
—
—
0
0
55
401
1.38
1.49
1.0
1.0
1.01
3.18
eliau/ml
2.44
17
176
202
1727
1.18
1.48
2.1
1.9
1.48
1.38
g/l
0.17
180
1595
59
438
1.35
1.44
1.4
1.4
0.32
0.44
nmol/l
1.18
45
333
5
16
3.13
1.44
1.0
1.0
—
—
—
0
0
26
164
1.59
1.43
1.2
1.4
81.15
75.61
umol/l
0.35
26
164
46
329
1.40
1.41
1.9
2.0
7.89
6.61
umol/l
0.21
31
235
122
1004
1.22
1.36
2.5
2.3
10.27
10.22
g/l
0.04
110
897
5
17
2.94
1.36
1.0
1.0
—
—
—
0
0
28
183
1.53
1.34
1.3
1.3
—
—
—
0
0
21
128
1.65
1.33
1.4
1.8
0.43
4.73
u/field
1.69
14
83
103
836
1.24
1.31
3.2
3.1
2.26
3.83
ratio
0.69
60
468
257
2265
1.15
1.30
7.5
7.1
9.27
9.43
mmol/l
0.15
241
2188
5
18
2.78
1.28
1.2
1.1
—
—
—
0
0
247
2179
1.15
1.24
1.4
1.4
—
—
—
0
0
6
25
2.40
1.24
1.3
3.0
1.33
0.80
u/field
—
6
25
96
780
1.24
1.23
1.2
1.1
3.60
4.47
—
9
103
158
1349
1.18
1.22
1.6
1.5
—
—
—
0
0
5
19
2.63
1.21
1.2
1.3
—
—
—
0
0
8
37
2.17
1.21
1.5
1.1
—
—
—
0
0
27
181
1.50
1.18
1.3
1.3
—
—
—
0
0
48
359
1.34
1.16
1.1
1.1
1.53
1.51
g/l
0.20
43
331
198
1733
1.15
1.13
1.6
1.7
—
—
—
0
0
17
103
1.65
1.12
1.0
1.1
92.14
209.26
iu/ml
2.80
17
103
100
829
1.21
1.09
2.2
1.5
602.96
286.66
mu/l
0.62
94
757
23
152
1.52
1.08
2.0
1.5
0.98
1.31
nmol/l
0.62
16
107
19
120
1.59
1.08
1.8
1.6
40.72
40.48
g/l
0.05
19
120
60
471
1.28
1.06
1.8
1.6
—
—
—
0
0
112
944
1.19
1.04
3.3
3.3
48.64
55.63
mg/l
0.30
100
810
27
187
1.45
1.03
1.1
1.1
0.16
18.82
nmol/l
—
7
31
43
324
1.33
1.02
1.1
1.0
—
—
—
0
0
701
6606
1.08
1.02
4.2
4.1
3.03
1.25
kg/l
0.42
500
4369
65
519
1.26
1.01
2.1
2.5
99.75
75.48
ug/min
0.38
38
302
112
947
1.19
1.01
3.3
3.3
35.59
55.30
mg/l
0.86
99
814
100
837
1.20
1.00
2.9
2.3
0.00
0.00
g/l
-0.00
88
733
93
773
1.21
1.00
1.1
1.1
0.80
8.97
eliau/ml
—
7
85
33
239
1.38
1.00
1.5
1.2
0.64
0.86
u/ml
0.13
16
126
625
5871
1.08
0.99
1.5
1.5
—
—
—
0
0
42
318
1.33
0.98
1.1
1.2
—
—
—
0
0
7
36
1.95
0.97
1.0
1.0
—
—
—
0
0
27
190
1.42
0.96
2.1
2.5
747.30
654.16
ml
0.55
20
128
38
284
1.34
0.96
2.2
1.6
—
—
—
0
0
93
777
1.20
0.96
3.0
2.3
0.00
0.00
g/l
-0.00
88
732
75
613
1.23
0.96
3.1
3.3
35.80
850.75
u/ml
1.22
67
556
74
604
1.23
0.96
1.1
1.1
1.16
1.99
u/ml
0.55
40
322
55
434
1.27
0.95
1.1
1.1
1.55
3.16
—
6
69
7
37
1.89
0.94
2.9
2.1
—
—
—
0
0
121
1038
1.17
0.94
1.9
1.9
1.27
2.07
ug/l
0.66
104
933
6
27
2.22
0.93
1.0
1.1
4.48
5.23
nmol/l
—
6
27
6
27
2.22
0.93
1.0
1.0
—
—
—
0
0
70
854
0.82
0.93
1.6
1.3
—
—
—
0
0
36
269
1.34
0.92
2.2
1.6
—
—
—
0
0
6
28
2.15
0.91
1.2
1.3
6.10
5.87
mmol/l
—
6
28
30
218
1.38
0.91
1.2
1.2
—
—
—
0
0
60
482
1.25
0.91
1.0
1.1
0.98
0.99
u/ml
0.01
29
206
122
1051
1.17
0.91
1.8
1.7
3.81
4.32
mg/l
0.23
99
803
141
1612
0.87
0.89
5.5
6.5
24.39
24.54
mmol/l
0.23
131
1529
12
194
0.62
0.89
1.3
1.4
—
—
—
0
0
99
1161
0.85
0.88
1.5
1.5
—
—
—
0
0
65
530
1.23
0.87
2.1
2.7
16.50
16.21
%
0.33
65
516
24
169
1.42
0.87
1.1
1.2
—
—
—
0
0
30
221
1.36
0.85
1.9
1.4
—
—
—
0
0
30
221
1.36
0.85
1.9
1.4
—
—
—
0
0
30
221
1.36
0.85
1.9
1.4
—
—
—
0
0
758
7215
1.07
0.84
3.6
3.9
92.95
92.31
%
0.30
743
7053
42
329
1.28
0.80
1.1
1.2
61.43
54.15
u/l
0.40
37
291
11
176
0.62
0.79
1.1
1.6
—
—
—
0
0
15
223
0.67
0.78
1.1
1.5
—
—
—
0
0
67
556
1.21
0.78
1.4
1.2
—
46.69
—
0
11
23
165
1.40
0.77
1.3
1.6
7.98
8.08
mmol/l
0.08
23
157
20
140
1.43
0.76
1.2
1.1
—
—
—
0
0
57
467
1.22
0.76
1.1
1.1
1.75
1.53
u/ml
0.06
32
226
35
271
1.29
0.74
2.8
3.8
—
—
—
0
0
41
325
1.27
0.73
1.5
1.6
54.17
58.19
%
0.28
24
203
112
979
1.15
0.73
1.9
2.1
294.84
714.31
ug/l
1.03
102
923
7
39
1.80
0.72
1.0
1.0
—
—
—
0
0
260
2822
0.91
0.71
2.3
2.4
36.80
39.14
u/l
0.33
209
2370
53
435
1.22
0.71
1.2
1.2
6.77
4.73
u/ml
0.35
26
165
37
466
0.79
0.70
1.8
1.8
—
—
—
0
0
300
2780
1.09
0.70
2.1
2.2
0.22
0.21
g/l
0.90
283
2625
33
256
1.29
0.70
1.2
1.2
—
—
titre
—
0
0
246
2260
1.10
0.70
3.1
2.6
66.54
67.45
ml/min/173m2
0.14
121
948
9
145
0.62
0.69
1.6
1.6
—
—
—
0
0
39
310
1.26
0.69
1.4
1.3
276.00
275.40
mosm/kgh2o
0.07
32
237
16
110
1.46
0.68
2.4
3.2
1.06
1.24
%
0.26
16
110
51
419
1.22
0.68
1.1
1.1
—
—
—
0
0
98
1120
0.87
0.67
1.4
1.5
774.83
1064.96
mu/l
3.29
72
900
291
3133
0.92
0.67
5.5
7.4
5.04
5.11
kpa
0.80
274
3006
44
539
0.81
0.66
1.4
1.3
—
—
—
0
0
44
539
0.81
0.66
1.4
1.3
—
—
—
0
0
291
3130
0.92
0.65
5.5
7.4
13.47
12.67
kpa
1.55
274
3005
25
189
1.33
0.64
1.4
1.5
8.49
6.15
u/l
0.40
18
154
5
29
1.73
0.64
1.0
1.1
—
—
—
0
0
38
305
1.25
0.63
1.3
1.8
90.81
90.03
%
0.27
38
300
51
423
1.21
0.63
1.3
1.2
20.04
36.50
u/l
1.04
43
360
25
192
1.30
0.59
3.4
2.0
—
—
—
0
0
13
89
1.46
0.58
1.2
1.1
—
—
—
0
0
67
776
0.86
0.57
3.3
3.4
2.06
2.19
index
0.08
32
401
8
54
1.48
0.57
2.8
1.6
0.48
0.45
e9/l
—
8
54
305
3252
0.93
0.57
1.8
1.8
—
—
—
0
0
30
238
1.26
0.56
1.2
1.5
36.77
32.77
%
0.24
16
143
15
107
1.40
0.55
1.4
2.6
—
30302.81
—
0
16
86
758
1.14
0.54
1.4
1.4
—
—
—
0
0
290
3091
0.93
0.54
5.4
7.4
0.90
1.03
mmol/l
0.28
232
2542
12
82
1.47
0.54
1.1
1.2
—
—
—
0
0
22
283
0.78
0.53
1.5
1.4
56201.08
52585.64
e6/l
0.03
12
148
6
39
1.54
0.53
1.2
1.1
—
—
—
0
0
6
40
1.50
0.51
1.0
1.8
18.13
16.17
umol/l
—
6
40
24
188
1.28
0.51
1.1
1.4
—
660.00
—
0
15
49
416
1.18
0.51
1.1
1.4
—
—
—
0
0
256
2731
0.93
0.50
5.6
7.8
96.36
95.83
%
1.07
243
2635
33
270
1.22
0.49
3.0
3.7
55.56
56.43
%
0.07
27
238
7
45
1.56
0.49
1.1
1.6
—
—
—
0
0
61
530
1.15
0.48
1.2
1.4
—
—
—
0
0
60
521
1.15
0.48
1.2
1.1
11.38
19.33
au/ml
0.51
15
125
14
189
0.74
0.48
1.4
1.3
9.00
10.78
u/l
0.54
14
174
25
199
1.26
0.48
3.2
1.9
19.12
15.64
%
0.78
25
194
329
3115
1.06
0.47
6.2
6.4
—
—
—
0
0
17
128
1.33
0.47
1.0
1.4
—
73.28
%
—
0
18
259
2434
1.07
0.47
5.6
7.3
1.19
1.28
mmol/l
1.03
254
2396
61
533
1.15
0.46
1.2
1.4
—
—
—
0
0
60
524
1.15
0.45
1.4
1.2
238.51
262.22
u/ml
0.33
39
310
12
164
0.73
0.45
1.1
1.2
—
—
—
0
0
15
112
1.34
0.44
1.5
2.2
—
—
—
0
0
49
423
1.16
0.43
3.1
3.7
3.07
1.48
%
0.81
42
385
5
31
1.61
0.43
1.0
1.1
3.24
8.17
u/ml
—
5
31
47
543
0.86
0.43
1.3
1.6
—
—
—
0
0
76
849
0.89
0.42
1.1
1.1
0.61
0.62
ratio
—
8
125
17
131
1.30
0.42
1.0
1.2
10.12
10.55
mm/h
0.05
17
131
5
33
1.52
0.41
1.8
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
0.04
—
0
15
0
15
0.00
0.41
0.0
3.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
11
79
1.39
0.40
1.2
1.2
114.82
114.18
%
0.02
11
74
5
34
1.47
0.40
1.0
1.5
—
—
—
0
0
71
793
0.89
0.40
1.2
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
21.74
—
0
10
0
18
0.00
0.40
0.0
1.1
—
45.46
—
0
5
54
613
0.88
0.39
1.7
1.6
—
—
—
0
0
13
97
1.34
0.39
15.1
14.6
0.66
0.60
mmol/l
0.80
13
87
27
324
0.83
0.39
1.4
1.5
5455.79
4880.65
e6/l
0.04
19
222
56
494
1.14
0.39
1.4
2.3
0.84
0.83
nmol/l
0.02
44
419
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
91
827
1.10
0.38
2.8
2.9
0.37
0.37
iu/ml
0.06
55
444
5
36
1.39
0.38
1.0
1.4
—
—
—
0
0
64
572
1.12
0.37
1.5
1.5
—
—
—
0
0
39
450
0.86
0.36
1.5
1.6
—
—
—
0
0
21
171
1.23
0.35
1.0
1.5
—
—
—
0
0
39
338
1.16
0.35
1.1
1.1
—
—
—
0
0
18
144
1.25
0.35
1.3
1.3
5.79
5.77
mmol/l
0.04
18
137
63
701
0.90
0.35
3.9
3.6
17.79
29.43
u/ml
2.57
63
683
245
2577
0.95
0.35
5.9
8.2
121.58
119.84
g/l
0.65
237
2510
58
647
0.89
0.34
1.3
1.5
58.28
61.36
ug/l
0.21
46
522
50
443
1.13
0.34
1.3
1.2
5.00
4.21
u/ml
0.10
19
141
83
907
0.91
0.33
1.1
1.1
1.59
1.60
g/l
0.14
83
907
15
118
1.27
0.33
4.6
4.7
—
—
—
0
0
6
86
0.70
0.33
3.7
2.7
120.50
143.97
nmol/l
—
6
75
25
210
1.19
0.32
1.2
1.6
—
—
—
0
0
348
3346
1.05
0.32
2.4
2.7
6.08
7.84
umol/l
2.11
301
2920
12
92
1.31
0.31
1.1
1.1
—
—
—
0
0
75
685
1.10
0.31
1.5
1.5
—
—
—
0
0
72
787
0.91
0.30
1.2
1.2
—
—
—
0
0
167
1765
0.94
0.29
1.8
2.0
—
—
—
0
0
24
282
0.85
0.29
1.4
1.5
—
—
—
0
0
7
56
1.25
0.29
1.3
1.3
1.22
1.18
mmol/l
—
7
56
12
152
0.79
0.29
1.0
1.1
—
—
—
0
0
18
148
1.22
0.29
1.4
2.4
7.98
8.19
mmol/l
0.10
18
148
22
185
1.19
0.29
1.0
1.4
—
51.88
—
0
16
2245
22623
0.97
0.29
21.1
19.0
13.53
13.61
%
2.64
2224
22329
8
110
0.73
0.28
1.0
1.1
—
—
—
0
0
84
776
1.08
0.28
3.1
3.1
1.64
1.51
mg/l
0.57
73
717
79
728
1.09
0.28
1.6
1.5
—
—
—
0
0
22
259
0.85
0.28
1.5
1.4
6.28
6.40
mmol/l
0.09
22
250
8
62
1.29
0.28
2.1
4.0
4.55
4.94
kpa
—
8
62
8
62
1.29
0.28
2.1
4.0
11.05
10.25
kpa
—
8
62
8
63
1.27
0.27
1.1
2.7
6.12
5.06
ug/l
—
8
63
39
346
1.13
0.27
1.3
1.6
—
—
—
0
0
30
261
1.15
0.27
1.2
1.2
—
—
—
0
0
17
140
1.22
0.27
1.1
1.1
1721.06
1518.78
miu/ml
0.25
17
140
9
120
0.75
0.27
25.2
14.3
1010.00
854.69
nmol/l
—
9
113
61
558
1.10
0.26
5.2
5.4
205.50
359.39
iu/ml
—
6
75
49
443
1.11
0.26
3.3
2.6
4693.80
1117.81
u/ml
—
5
27
5
74
0.68
0.26
1.2
1.1
—
—
—
0
0
37
329
1.13
0.26
1.3
1.5
—
—
—
0
0
15
181
0.83
0.25
1.1
1.1
—
87.60
—
0
5
9
75
1.20
0.25
1.0
1.3
—
—
—
0
0
32
361
0.89
0.24
2.2
2.2
596.03
1072.98
u/ml
0.22
32
356
23
265
0.87
0.24
1.0
1.1
—
—
—
0
0
18
152
1.19
0.23
1.1
1.3
122.44
135.11
nmol/l
0.67
18
152
43
389
1.11
0.23
1.4
1.3
31.02
62.55
u/ml
—
5
21
5
39
1.28
0.23
1.0
1.1
—
—
—
0
0
24
209
1.15
0.22
1.5
1.7
—
—
—
0
0
28
247
1.13
0.22
1.2
1.2
—
—
—
0
0
225
2169
1.04
0.21
1.7
1.7
3.51
3.49
mmol/l
0.10
161
1499
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
5.1
—
357.64
—
0
11
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
43
392
1.10
0.21
1.0
1.1
5.14
4.44
u/ml
0.06
21
168
18
209
0.86
0.21
1.0
1.0
45.06
45.26
ng/l
0.01
13
144
27
240
1.13
0.20
1.2
1.2
—
—
—
0
0
18
155
1.16
0.19
1.1
1.6
—
—
—
0
0
25
281
0.89
0.19
1.0
1.1
—
74.17
—
0
6
6
51
1.18
0.19
1.0
1.4
92.83
108.29
%
—
6
51
6
52
1.15
0.19
4.8
6.9
8.02
5.34
kpa
—
6
52
33
364
0.91
0.19
1.1
1.1
—
—
—
0
0
18
207
0.87
0.19
1.0
1.0
677.85
725.51
ng/l
0.19
13
139
15
175
0.86
0.18
1.3
1.5
10.27
12.41
u/l
0.94
15
168
67
629
1.07
0.18
1.2
1.4
—
—
—
0
0
131
1366
0.96
0.17
1.3
1.4
—
—
—
0
0
18
205
0.88
0.17
1.0
1.0
315.85
345.67
ng/l
0.30
13
141
35
320
1.09
0.17
1.2
1.6
2.22
3.86
ug/l
0.96
27
270
353
3451
1.03
0.16
1.8
1.8
—
—
—
0
0
8
69
1.16
0.16
1.6
1.3
—
—
—
0
0
8
71
1.13
0.16
1.1
1.0
—
—
—
0
0
42
389
1.08
0.16
1.0
1.1
42.78
29193.02
iu/ml
—
9
80
297
2898
1.03
0.16
1.9
1.9
3.43
3.33
ratio
0.79
236
2214
21
187
1.12
0.15
1.0
1.0
—
—
—
0
0
8
73
1.10
0.15
1.1
1.1
—
—
—
0
0
11
93
1.18
0.14
2.3
2.7
0.60
0.61
mmol/l
0.24
11
93
30
275
1.09
0.14
1.6
1.4
141158.32
73174.97
e6/l
0.22
22
185
23
208
1.11
0.14
1.1
1.1
16.52
16.33
u/ml
—
10
95
27
247
1.09
0.13
1.2
1.2
—
—
—
0
0
109
1049
1.04
0.13
1.5
1.6
0.21
0.34
mg/l
1.97
36
468
77
737
1.05
0.12
1.8
1.4
—
—
—
0
0
10
86
1.16
0.11
1.3
1.6
7.73
9.09
ug/l
—
10
86
158
1621
0.97
0.11
6.7
9.2
24.57
24.38
mmol/l
0.40
151
1600
14
156
0.90
0.10
1.1
1.2
—
—
—
0
0
136
1395
0.97
0.09
1.5
1.4
—
—
—
0
0
203
2071
0.98
0.09
3.3
2.8
215.50
174.30
ng/l
0.64
187
1890
541
5353
1.01
0.09
4.1
3.7
223.27
362.68
ng/l
0.55
384
4005
15
136
1.10
0.08
1.1
1.1
—
—
—
0
0
6
58
1.03
0.08
4.8
6.7
5.64
5.91
kpa
—
6
52
13
144
0.90
0.08
1.6
1.5
—
—
—
0
0
24
224
1.07
0.08
1.1
1.1
13.36
7.98
iu/ml
—
5
60
6
72
0.83
0.07
1.0
1.1
—
—
—
0
0
11
99
1.11
0.06
1.0
1.3
—
—
—
0
0
57
552
1.03
0.06
1.5
1.3
—
18.67
—
0
13
109
1111
0.98
0.05
3.4
3.5
191.76
1862.20
u/ml
1.11
88
954
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
15
139
1.08
0.05
1.0
1.1
—
—
—
0
0
15
139
1.08
0.05
1.3
1.4
—
—
—
0
0
15
139
1.08
0.05
1.3
1.4
—
—
—
0
0
92
939
0.98
0.05
2.3
2.7
—
—
—
0
0
15
161
0.93
0.05
1.1
1.2
0.55
0.56
ratio
—
7
99
25
238
1.05
0.05
1.0
1.1
—
—
—
0
0
25
238
1.05
0.05
1.2
1.2
—
—
—
0
0
63
646
0.97
0.05
1.3
1.7
—
—
—
0
0
143
1450
0.99
0.04
1.7
1.8
—
—
—
0
0
16
150
1.07
0.04
1.1
1.6
—
—
—
0
0
58
594
0.98
0.04
1.4
1.4
—
—
—
0
0
11
118
0.93
0.02
2.1
2.3
189.00
162.16
umol/l
—
6
67
40
390
1.03
0.02
1.7
1.5
—
—
—
0
0
59
601
0.98
0.02
1.4
1.5
0.90
1.20
ratio
3.88
35
355
59
601
0.98
0.02
1.4
1.5
0.93
0.96
ratio
0.22
35
354
59
601
0.98
0.02
1.4
1.5
1.18
1.16
ratio
0.09
35
354
295
2933
1.01
0.02
1.6
1.7
1.41
1.44
%
0.33
260
2567
43
420
1.02
0.02
1.0
1.1
1.58
3.41
u/ml
1.32
22
199
27
278
0.97
0.02
1.4
1.2
—
—
—
0
0
73
738
0.99
0.01
1.8
1.6
9105.65
10760.78
e6/l
0.17
57
520
16
159
1.01
0.00
1.0
1.0
1.27
1.15
u/l
—
6
77
50
495
1.01
0.00
1.3
1.3
148.88
157.25
au/ml
0.18
16
142
64
641
1.00
0.00
2.0
2.3
129.85
126.96
g/l
0.45
52
493
123
1225
1.00
0.00
1.9
1.8
1.54
1.55
g/l
0.03
106
1059
52
516
1.01
0.00
3.2
3.3
0.81
0.80
nmol/l
0.07
40
421
62
624
0.99
0.00
1.3
1.4
15.65
37.82
e6/l
0.82
49
454
28
282
0.99
0.00
4.5
3.4
17.31
12.94
index
0.61
16
167
77
768
1.00
0.00
1.8
1.7
—
—
—
0
0
64
637
1.00
0.00
1.4
1.5
980.12
1352.95
e6/l
0.23
56
494
10
97
1.03
0.00
1.7
1.2
—
—
—
0
0
22
223
0.99
0.00
2.1
2.7
38.94
28.45
mg/l
0.44
17
155
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
5
54
0.93
0.00
1.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
28.08
—
0
6
5
59
0.85
-0.00
1.4
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1.33
—
0
6
6
59
1.02
-0.00
1.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
61
0.98
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.5
—
—
—
0
0
36
360
1.00
-0.00
1.0
1.0
0.09
0.24
u/ml
0.88
12
118
0
9
0.00
-0.00
0.0
1.0
—
273.67
—
0
9
6
66
0.91
-0.00
1.2
1.0
32.05
30.45
iu/ml
—
6
66
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
97
0.93
-0.00
1.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_GOITRENOD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GOITRENOD | 0.933 [0.84, 1.03] | 0.168 |
| Birth year | 0.994 [0.99, 1.0] | 0.161 |
During the follow-up period (1.1.1998 — 31.12.2019), 978 out of 10026 females with E4_GOITRENOD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GOITRENOD | 0.863 [0.76, 0.98] | 0.019 |
| Birth year | 0.993 [0.98, 1.0] | 0.145 |
During the follow-up period (1.1.1998 — 31.12.2019), 395 out of 2426 males with E4_GOITRENOD died.
Mortality risk
Mortality risk for people of age
years, who have E4_GOITRENOD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.064% | 0.205% |
| 5 | 0.56% | 1.157% |
| 10 | 1.27% | 3.068% |
| 15 | 2.514% | 5.741% |
| 20 | 4.303% | 10.132% |
Relationships between endpoints
↥Index endpoint: E4_GOITRENOD – Nontoxic single thyroid nodule
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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