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Prophylactic surgery

Z21_PROPHYLACT_SURGE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Z40
  • Cause of death: ICD-10 Z40

2 out of 7 registries used, show all original rules.

324

4. Check minimum number of events

None

324

5. Include endpoints

None

324

6. Filter based on genotype QC (FinnGen only)

286

Control definitions (FinnGen only)

Control exclude
Z21_PERSONS_ENCOUNTERI_HEALTH_SERVI_SPECIFIC_PROCED_HEALTH_CARE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Z4|Z5[0-4]

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 286 270 16
Unadjusted period prevalence (%) 0.09 0.10 0.01
Median age at first event (years) 45.96 45.81 48.44

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
311
Matched controls
3110
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z40.0
ICD-10 Finland
Prophylactic surgery for risk-factors related to malignant neoplasms
8577.0
307.7
264
*
Z80.3
ICD-10 Finland
Family history of malignant neoplasm of breast
113.3
307.7
199
48
HAE10
NOMESCO Finland
Reconstruction of breast using graft or flap
99.7
229.2
122
20
Z31.5
ICD-10 Finland
Genetic counselling
29.5
211.5
189
155
HAE99
NOMESCO Finland
Other reconstruction of breast
94.4
191.6
102
16
HAC15
NOMESCO Finland
Subcutaneous mastectomy with excision of mamilla
94.9
184.5
98
15
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
22.9
152.2
132
97
HA1CG
NOMESCO Finland
Extensive MRI examination of mammary gland with high intensity magnet
41.6
150.1
96
33
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
15.7
129.6
148
170
TQW20
NOMESCO Finland
Tatoe
65.4
126.4
71
14
HAC20
NOMESCO Finland
Total mastectomy
24.8
117.7
91
51
HA1AA
NOMESCO Finland
X-ray mammography
14.2
117.5
141
172
HAE20
NOMESCO Finland
Reconstruction of areola and mamilla using graft or flap
45.7
116.3
71
20
R4110
NOMESCO Finland
Physiotherapy
13.3
115.8
221
486
Z42.1
ICD-10 Finland
Follow-up care involving plastic surgery of breast
+∞
98.3
89
*
TQB05
NOMESCO Finland
Puncture of skin of trunk
65.1
96.5
54
10
115
Kela drug reimbursment
Breast cancer
11.6
96.2
130
182
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
12.9
84.8
96
104
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
18.8
83.8
72
49
THW99
NOMESCO Finland
Other minor procedure in surgery of mammary gland
25.8
80.7
59
28
QB2S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in chest
41.4
79.1
49
14
PJA12
NOMESCO Finland
Sentinel node biopsy
9.9
78.5
114
171
H02AB02
ATC
dexamethasone; systemic
9.8
78.3
115
175
Z85.3
ICD-10 Finland
Personal history of malignant neoplasm of breast
19.9
73.0
60
37
WX402
NOMESCO Finland
General anaesthesia
7.5
71.3
177
467
C50.90
ICD-10 Finland
Malignant tumor in other or unspecified location in mammary gland without histology
41.4
69.6
43
12
L02BA01
ATC
tamoxifen; oral
12.3
68.7
77
81
WX404
NOMESCO Finland
Intravenous generell anesthesy
7.1
67.6
170
450
B01AB05
ATC
enoxaparin; parenteral
6.8
64.0
186
558
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
10.1
59.4
77
98
ZXE40
NOMESCO Finland
More than seven and less than nine hours
26.8
59.2
42
18
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
26.1
57.2
41
18
HAC10
NOMESCO Finland
Subcutaneous mastectomy with preservation of mamilla
123.4
57.1
60
6
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
12.9
51.8
54
50
QBE30
NOMESCO Finland
Excision and repair of surgical scar in trunk
92.6
49.8
54
7
HAE00
NOMESCO Finland
Reconstruction of breast using prosthesis
121.5
48.4
51
5
ZXA00
NOMESCO Finland
Right side
5.4
46.7
138
400
A03FA01
ATC
metoclopramide; systemic, rectal
5.3
46.3
148
458
ZXD10
NOMESCO Finland
Scheduled procedure
5.4
46.2
205
824
ZXE30
NOMESCO Finland
More than five and less than seven hours
12.2
45.8
49
47
HAD60
NOMESCO Finland
Replacement of prosthetic implant in breast
506.7
45.5
44
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
10.5
45.1
54
61
ZXE10
NOMESCO Finland
More than one and less than three hours
5.0
44.0
189
733
ZXA05
NOMESCO Finland
Left side
5.3
43.9
125
349
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
9.6
42.8
55
68
WX408
NOMESCO Finland
General anesthesy, balanced
4.8
41.1
144
472
HA1CM
NOMESCO Finland
Mammary gland extensive MRI examination with 3 Tesla magnet
156.8
39.8
41
*
TPH07
NOMESCO Finland
Cathetrisation of artery
7.5
39.0
63
102
C50.99
ICD-10 Finland
Breast, unspecified
11.0
38.6
44
46
HA1AT
NOMESCO Finland
Biopsy of mammary glands with ultrasound guidance
10.7
37.1
43
46
R4120
NOMESCO Finland
Occupational therapy
7.3
35.9
59
97
ZZF00
NOMESCO Finland
Graft of adipose tissue
40.2
33.8
42
12
HAD20
NOMESCO Finland
Liposuction of breast
131.0
33.4
35
*
A04AA01
ATC
ondansetron; systemic, rectal
6.6
33.0
60
109
A04AD12
ATC
aprepitant; systemic
13.6
32.9
32
26
Z2221
NOMESCO Finland
Medical doctor
4.0
32.9
163
667
ZZR10
NOMESCO Finland
Flap of skin and muscle
52.2
31.4
37
8
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
5.2
31.3
77
185
A04AA02
ATC
granisetron; systemic, transdermal
7.5
30.8
48
74
Z80.4
ICD-10 Finland
Family history of malignant neoplasm of genital organs
63.3
29.8
34
6
JN4BD
NOMESCO Finland
Extensive body CT
6.2
29.7
57
109
Z40.8
ICD-10 Finland
Other prophylactic surgery
+∞
29.7
28
*
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
8.1
29.2
42
59
Z3226
NOMESCO Finland
Physiotherapist
4.3
28.9
96
292
ZXE20
NOMESCO Finland
More than three and less than five hours
5.0
28.7
74
184
Z3231
NOMESCO Finland
Registered nurse
3.8
27.9
126
474
A04AA55
ATC
palonosetron, combinations; systemic
6.7
27.4
47
80
Z80.0
ICD-10 Finland
Family history of malignant neoplasm of digestive organs
31.1
27.4
36
13
TQW99
NOMESCO Finland
Other minor procedure on skin
8.3
26.5
37
50
8500/3-C50.4
ICD-O-3
Infiltrating duct carcinoma, NOS, of upper-outer quadrant of breast
8.4
26.0
36
48
ZXA10
NOMESCO Finland
Bilateral
4.1
26.0
92
291
HAE05
NOMESCO Finland
Reconstruction of breast using soft tissue and prosthesis
63.7
25.5
29
5
C50
ICD-10 Finland
Malignant neoplasm of breast
7.8
25.2
37
53
L01BC06
ATC
capecitabine; oral
9.9
24.2
29
32
ZX120
NOMESCO Finland
Intravenous
5.5
24.1
52
110
D05.1
ICD-10 Finland
Intraductal carcinoma in situ
10.1
23.0
27
29
L03AA13
ATC
pegfilgrastim; parenteral
6.1
22.3
42
78
ZXE00
NOMESCO Finland
One hour or less
3.1
21.9
176
912
HAD50
NOMESCO Finland
Removal of prosthetic implant from breast
47.1
21.8
26
6
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
3.5
21.8
97
354
L02BG06
ATC
exemestane; oral
9.0
21.7
28
34
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
6.4
21.6
38
66
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
6.5
21.4
37
63
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
51.7
20.5
24
5
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
6.6
20.4
35
59
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
6.3
19.8
35
61
Z40.9
ICD-10 Finland
Prophylactic surgery, unspecified
+∞
18.9
18
*
1CD02, ,
NOMESCO Finland
17.6
18.7
29
18
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
5.4
18.6
39
80
LCD04
NOMESCO Finland
Laparoscopic hysterectomy
5.3
18.3
40
85
HAD55
NOMESCO Finland
Incision of periprosthetic capsule of breast
+∞
17.9
17
*
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
39.3
17.9
22
6
QBB05
NOMESCO Finland
Revision of wound of skin of trunk
30.9
17.7
23
8
L02AE03
ATC
goserelin; implant
20.1
17.6
26
14
B01AB04
ATC
dalteparin; parenteral
5.7
17.0
33
63
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
5.0
16.9
39
87
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.7
16.8
177
1014
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
7.8
16.8
24
33
HA6AA
NOMESCO Finland
Extra corporeal mammography of operated mammary gland
5.2
16.6
36
76
L02BG04
ATC
letrozole; oral
3.9
16.4
55
164
QBJ00
NOMESCO Finland
Liposuction in trunk
32.0
16.3
21
7
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
35.5
15.9
20
6
X76
ICPC
Malignant neoplasm breast female
7.7
15.9
23
32
PD1BD
NOMESCO Finland
Extensive CT of abdominal aorta and branches
89.7
15.7
17
*
ZXM40
NOMESCO Finland
Use of fluorescent substance
168.1
15.6
16
*
HA4AT
NOMESCO Finland
Labeling mammary gland pathology with ultrasound guidance
5.8
15.3
29
54
ZXD20
NOMESCO Finland
Day surgery
3.3
14.8
64
225
QB9S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in torso, unspecified
38.1
14.6
18
5
C50.91
ICD-10 Finland
Malignant tumor in another specified localization in ductal mammary gland
12.8
14.4
25
21
HAB40
NOMESCO Finland
Wedge excision of mammary gland
4.4
14.3
38
95
ZX090
NOMESCO Finland
Other technic of radiotherapy
7.1
14.2
22
33
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
3.9
13.9
45
130
C50.81
ICD-10 Finland
Overall malignant tumor of the mammary gland, ductal tumor
10.8
13.8
26
26
C50.51
ICD-10 Finland
Malignant tumor of the lower outer quadrant of the mammary gland, ductal tumor
13.7
13.6
23
18
HAD57
NOMESCO Finland
Resection of periprosthetic capsule of breast
146.1
13.6
14
*
HWA00
NOMESCO Finland
Repair of wound dehiscence in surgery of mammary gland
22.4
13.5
19
9
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
13.3
119
613
WX110
NOMESCO Finland
Infiltration anesthesia
3.4
13.2
268
2022
HA013
NOMESCO Finland
Radiotherapy after total ablation of mammary gland
11.7
12.8
23
21
R2110
NOMESCO Finland
Giving the first information
3.5
12.4
47
151
HWD00
NOMESCO Finland
Reoperation for deep haemorrhage in surgery of mammary gland
19.0
12.2
18
10
Z80.8
ICD-10 Finland
Family history of malignant neoplasm of other organs or systems
24.0
11.7
16
7
ZZS50
NOMESCO Finland
Insertion of tissue expander
+∞
11.5
11
*
PJ3AT
NOMESCO Finland
Cytology of lymphnode with ultrasound guidance
12.5
11.5
20
17
N64.9
ICD-10 Finland
Disorder of breast, unspecified
10.2
11.4
22
23
HWH99
NOMESCO Finland
Other reoperation in surgery of mammary gland
26.1
11.2
15
6
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
14.6
11.1
18
13
HA1TE
NOMESCO Finland
Supplementary or limited ultrasound examination of mammary glands
14.6
11.1
18
13
N63
ICD-10 Finland
Unspecified lump in breast
3.1
11.1
50
179
L02AE02
ATC
leuprorelin; implant, parenteral
5.7
11.0
21
39
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.4
10.5
21
41
N02BE01
ATC
paracetamol; systemic, rectal
5.3
10.4
297
2491
HA3AT
NOMESCO Finland
Pucture of mammary gland cyst with ultrasound examination
19.6
10.4
15
8
X21
ICPC
Breast sympt/compl female other
5.1
10.2
22
46
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
10.1
134
799
Z31.6
ICD-10 Finland
General counselling and advice on procreation
12.8
10.0
17
14
I97.2
ICD-10 Finland
Postmastectomy lymphoedema syndrome
17.4
10.0
15
9
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
11.2
9.9
18
17
Z73.3
ICD-10 Finland
Stress, not elsewhere classified
11.2
9.9
18
17
HAD99
NOMESCO Finland
Other plastic operation on breast
14.0
9.8
16
12
FM1FN
NOMESCO Finland
Heart function isotope examination
31.1
9.5
12
*
Z51.5
ICD-10 Finland
Palliative care
22.5
9.4
13
6
Z80.9
ICD-10 Finland
Family history of malignant neoplasm, unspecified
+∞
9.4
9
*
Y83.4
ICD-10 Finland
Other reconstructive surgery as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
+∞
9.4
9
*
ZZS55
NOMESCO Finland
Distension of tissue expander
+∞
9.4
9
*
J01DB01
ATC
cefalexin; oral
3.2
9.4
280
2296
WB401
NOMESCO Finland
Simple antibody therapy of primary tumour
12.0
9.2
16
14
C50.31
ICD-10 Finland
Malignant tumor of the lower inner quadrant of the mammary gland, ductal tumor
10.5
9.1
17
17
L03AA02
ATC
filgrastim; parenteral
7.8
9.1
20
27
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
37.9
9.1
11
*
C50.21
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor
7.2
9.0
21
31
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
7.3
8.7
20
29
ZX112
NOMESCO Finland
Subcutaneous
10.5
8.6
16
16
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.6
8.6
29
86
Z50.1
ICD-10 Finland
Other physical therapy
28.4
8.5
11
*
ZY010
NOMESCO Finland
Hospital outpatient
3.7
8.4
28
82
A02BC02
ATC
pantoprazole; systemic
2.1
8.4
221
1663
ZXD05
NOMESCO Finland
Urgent procedure
2.1
8.3
116
694
TQW40
NOMESCO Finland
Remowal of suture of skin
3.5
8.3
30
93
HA1AE, ,
SPAT
3.6
8.3
28
83
M05BX04
ATC
denosumab; parenteral
4.6
8.3
20
46
QBE20
NOMESCO Finland
Excision and repair of scar or web of skin of trunk
15.0
8.3
13
9
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
15.0
8.3
13
9
ACC19
NOMESCO Finland
Transcision of peripheral nerve: other or unspecified
15.0
8.3
13
9
SPAT1324
SPAT
Screening procedure
0.3
8.1
25
690
LCA06
NOMESCO Finland
Biopsy of endometrium
2.3
8.0
70
347
C50.49
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, other or undeterminated histology
8.1
8.0
17
22
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.4
7.9
30
96
N02AX02
ATC
tramadol; systemic, rectal
2.0
7.8
132
843
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
2.3
7.7
69
345
ZZQ10
NOMESCO Finland
Free microvascular graft of skin and muscle
18.9
7.7
11
6
C50.11
ICD-10 Finland
Malignant tumor of the central part of the mammary gland,ductal tumor
9.2
7.6
15
17
1XC03, ,
NOMESCO Finland
25.7
7.6
10
*
N02AA05
ATC
oxycodone; systemic
2.7
7.6
43
174
TQW11
NOMESCO Finland
Vacuum treatment of wound
8.0
7.5
16
21
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
3.2
7.1
29
97
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.1
7.1
31
108
B01AB10
ATC
tinzaparin; parenteral
2.7
7.1
40
161
8500/2-C50.9
ICD-O-3
Intraductal carcinoma, noninfiltrating, NOS, of breast, NOS
10.4
7.1
13
13
WB123
NOMESCO Finland
Demanding adjuvant cytostatic therapy
14.2
6.9
11
8
HAD30
NOMESCO Finland
Reduction mammoplasty with transposition of areola
3.4
6.7
25
79
TQD05
NOMESCO Finland
Puncture of skin of lower limb
23.1
6.7
9
*
QWF00
NOMESCO Finland
Reoperation for insufficiency of suture in plastic surgery of skin
71.3
6.4
7
*
S18
ICPC
Laceration/cut
1.8
6.3
140
959
WX702
NOMESCO Finland
Supraglottic ventilation device
3.1
6.3
26
88
JJ1CE
NOMESCO Finland
Liver, bile duct and pancreas endoscopic ultrasound examination
+∞
6.3
6
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
6.3
6
*
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.3
6.0
23
74

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
95
58
23.14
118.22
2.9
3.1
18.67
29.47
u/ml
0.42
90
58
125
188
10.45
86.63
3.3
3.9
5.24
6.79
ug/l
0.21
79
146
152
387
6.73
62.12
1.9
1.2
—
—
—
0
0
72
101
8.98
51.04
9.6
6.3
24.39
24.51
mmol/l
0.11
72
101
83
139
7.78
50.43
8.8
6.9
—
—
—
0
0
217
876
5.89
49.74
2.8
1.9
—
—
—
0
0
72
109
8.29
47.71
1.5
1.4
—
—
—
0
0
183
660
5.31
47.62
2.4
1.8
—
—
—
0
0
40
32
14.20
41.72
1.1
1.1
—
—
—
0
0
69
115
7.43
41.69
10.0
7.7
0.86
0.64
%
3.25
69
115
69
117
7.29
40.99
10.0
7.6
96.53
93.96
%
3.52
69
117
68
117
7.16
39.79
10.1
7.6
1.31
1.23
%
0.28
68
117
82
175
6.01
38.58
9.0
6.3
-0.11
0.65
mmol/l
1.35
77
147
88
202
5.68
38.22
1.5
1.4
—
—
—
0
0
82
177
5.93
38.08
9.0
6.3
7.40
7.42
ph
0.49
13
93
233
1214
4.67
33.26
3.1
2.0
—
—
—
0
0
34
31
12.19
32.55
1.1
1.1
—
—
—
0
0
42
57
8.36
30.03
3.2
2.9
11.10
2891.12
u/ml
0.62
34
49
234
1311
4.17
28.00
3.3
2.4
—
—
estimate
—
0
0
83
233
4.49
27.63
7.8
5.9
105.93
104.85
mmol/l
1.65
83
233
162
786
3.21
22.85
8.8
5.3
—
—
—
0
0
88
304
3.64
21.45
2.1
1.8
—
—
—
0
0
183
993
3.05
20.53
7.4
4.5
1.18
1.22
mmol/l
8.48
171
925
162
849
2.90
18.93
7.5
2.6
2.37
2.36
mmol/l
0.81
156
790
209
1277
2.94
17.89
9.7
5.0
9.89
9.74
umol/l
0.12
204
1220
108
467
3.01
17.80
3.4
3.4
—
—
—
0
0
191
1133
2.78
16.96
8.0
5.0
1.19
1.22
mmol/l
8.75
174
990
80
337
2.85
13.40
2.8
2.3
3.84
4.17
e6/l
0.09
35
145
222
1524
2.60
13.09
12.2
8.5
3.60
3.88
e9/l
1.25
188
1324
119
621
2.48
12.86
2.9
2.5
0.12
0.30
e6/l
1.64
74
421
22
40
5.84
11.82
1.0
1.1
—
—
—
0
0
60
233
2.95
11.54
3.2
2.1
30.82
32.21
u/l
0.11
50
197
128
724
2.31
11.23
2.9
2.5
42.59
68.80
e6/l
0.33
84
521
64
263
2.80
11.07
2.0
1.4
—
—
—
0
0
149
906
2.24
10.90
3.6
3.1
42.96
55.39
e6/l
0.28
91
571
198
1356
2.27
10.73
7.0
3.6
6.49
6.29
mmol/l
0.97
193
1244
147
904
2.19
10.29
1.4
1.6
—
—
—
0
0
119
691
2.17
9.46
3.9
3.1
7.39
7.40
ph
1.60
79
471
292
2452
4.12
9.46
26.6
14.0
330.19
331.83
g/l
2.99
292
2441
108
650
2.01
7.49
1.7
1.7
1.37
0.94
mg/l
0.34
79
505
27
87
3.30
7.05
1.1
1.1
—
—
—
0
0
19
51
3.90
6.46
1.2
1.2
6.67
3.06
u/ml
—
9
18
21
66
3.34
5.71
1.1
1.2
—
—
—
0
0
21
69
3.19
5.33
1.2
2.4
3.67
1.13
index
—
9
31
16
36
4.63
5.13
2.3
2.1
—
—
—
0
0
65
373
1.94
4.95
3.0
2.8
54.22
383.94
ng/l
0.89
41
220
43
783
0.48
4.95
2.8
3.2
0.00
0.00
estimate
—
8
270
117
827
1.66
4.35
5.2
5.7
—
—
—
0
0
299
2759
3.17
4.12
17.2
10.2
25.79
18.88
mg/l
3.69
269
2150
210
1743
1.63
3.91
4.2
3.8
—
830.67
—
0
18
66
411
1.77
3.84
2.2
2.3
556.22
527.80
mosm/kgh2o
0.39
58
355
7
8
8.92
3.79
1.1
1.3
27.57
27.75
s
—
7
8
161
1262
1.57
3.76
5.6
5.8
29.73
29.63
%
0.05
155
1205
45
252
1.92
3.66
1.3
1.4
—
—
—
0
0
19
75
2.63
3.53
1.1
1.1
—
—
—
0
0
19
75
2.63
3.53
1.1
1.1
—
—
—
0
0
158
1255
1.53
3.35
5.7
5.7
55.78
56.44
%
0.34
153
1199
72
479
1.65
3.27
2.2
2.2
9.52
8.04
e6/l
0.26
62
425
52
316
1.78
3.27
1.4
1.4
—
—
—
0
0
59
377
1.70
3.11
1.2
1.5
—
—
—
0
0
8
17
4.80
2.94
1.1
1.1
—
—
—
0
0
148
1183
1.48
2.91
7.5
8.7
0.00
0.00
e9/l
0.50
102
964
152
1223
1.47
2.88
5.8
6.0
0.69
0.71
%
0.18
146
1142
51
320
1.71
2.87
1.9
1.9
2.38
2.44
g/l
0.29
46
298
169
1391
1.47
2.84
6.4
6.0
1.84
2.02
e9/l
1.21
145
1250
165
1353
1.47
2.82
6.4
6.1
0.04
0.04
e9/l
1.03
136
1184
152
1227
1.47
2.82
5.8
5.9
2.41
2.78
%
1.52
144
1151
164
1347
1.46
2.76
6.5
6.1
0.53
0.52
e9/l
0.28
135
1182
10
29
3.53
2.71
2.9
1.9
3.11
7.21
u/ml
—
10
29
8
209
0.37
2.66
2.0
3.0
—
—
—
0
0
151
1228
1.45
2.64
5.8
5.9
8.55
8.27
%
0.42
145
1156
7
15
4.75
2.61
5.6
5.6
10.00
11.09
mg/l
—
7
15
7
17
4.19
2.37
1.4
1.1
91.57
107.76
pmol/l
—
7
17
112
879
1.43
2.30
11.3
8.1
1.14
1.08
inr
0.58
87
694
167
1419
1.38
2.11
6.7
6.4
0.16
0.18
e9/l
0.51
140
1259
28
163
1.79
2.06
1.9
2.4
7.38
7.39
ph
0.23
14
79
40
258
1.63
2.05
1.2
1.2
—
—
—
0
0
95
737
1.42
2.05
2.8
2.2
—
—
—
0
0
12
51
2.41
1.97
3.3
2.2
—
—
—
0
0
5
11
4.60
1.95
1.0
1.8
0.48
0.48
e9/l
—
5
11
7
22
3.23
1.89
2.0
1.8
—
—
—
0
0
7
23
3.09
1.81
1.1
1.4
34.70
18.12
ng/l
—
7
23
6
18
3.38
1.75
1.0
1.2
—
—
—
0
0
18
98
1.89
1.65
2.2
1.8
—
—
—
0
0
59
444
1.41
1.50
3.1
1.9
2.43
2.43
mmol/l
0.14
53
409
14
74
1.93
1.41
1.1
1.4
247.00
319.54
ug/g
—
8
36
11
54
2.08
1.34
1.7
1.7
212.27
150.06
ug/l
0.24
11
49
24
154
1.61
1.30
1.4
1.4
1.28
1.30
mm
0.07
16
107
40
288
1.45
1.30
1.4
1.4
—
—
—
0
0
93
1108
0.77
1.29
2.5
3.0
0.00
0.03
estimate
—
8
244
24
156
1.58
1.24
1.4
1.4
—
—
—
0
0
77
623
1.31
1.24
2.2
2.2
314.14
308.05
umol/l
0.26
69
573
56
709
0.74
1.20
2.9
4.4
—
—
—
0
0
26
174
1.54
1.20
1.4
1.6
—
—
—
0
0
5
20
2.52
1.15
1.4
2.0
8.32
10.71
%
—
5
20
5
114
0.43
1.14
7.6
2.2
—
—
—
0
0
80
658
1.29
1.14
1.4
1.7
—
—
—
0
0
24
160
1.54
1.13
1.4
1.6
—
—
—
0
0
145
1284
1.24
1.11
2.8
2.4
78.04
76.63
nmol/l
0.28
138
1201
7
34
2.08
1.03
1.0
1.2
—
—
—
0
0
7
34
2.08
1.03
1.0
1.1
—
—
—
0
0
43
330
1.35
0.99
1.3
1.3
—
—
—
0
0
116
1315
0.81
0.99
2.4
2.6
—
—
—
0
0
68
816
0.79
0.97
2.0
2.6
41.67
0.02
estimate
—
6
230
7
37
1.91
0.94
1.4
1.8
51.29
60.35
%
—
7
37
23
162
1.45
0.87
1.1
1.1
0.83
0.89
g/l
0.68
23
162
248
2589
0.79
0.86
3.5
3.7
1.25
1.21
mmol/l
0.42
242
2451
23
314
0.71
0.81
1.4
1.6
874.70
964.08
mu/l
0.23
17
254
6
33
1.83
0.79
1.3
1.5
—
—
—
0
0
296
2891
1.49
0.76
12.5
9.6
—
—
—
0
0
11
67
1.67
0.76
1.0
1.0
0.26
0.95
u/ml
—
6
26
9
54
1.69
0.75
1.4
1.1
—
—
—
0
0
7
39
1.81
0.73
1.3
1.2
—
—
—
0
0
7
39
1.81
0.73
1.0
1.1
—
—
—
0
0
15
215
0.68
0.70
1.7
2.1
158.33
4564.96
u/l
—
9
92
90
791
1.19
0.70
1.7
1.9
—
—
—
0
0
14
94
1.51
0.68
3.4
2.5
1.02
1.02
ratio
0.07
14
88
270
2776
0.79
0.65
5.0
5.0
2.94
2.88
mmol/l
0.57
265
2656
5
29
1.74
0.64
1.0
1.4
—
—
—
0
0
44
527
0.81
0.62
1.5
1.7
—
—
—
0
0
40
327
1.26
0.62
1.4
1.3
39.82
26.17
iu/l
1.31
35
280
5
30
1.68
0.61
1.4
1.4
2.69
0.40
u/ml
—
5
14
266
2736
0.81
0.61
4.1
4.4
1.63
1.55
mmol/l
2.32
259
2612
17
231
0.72
0.61
2.2
1.8
—
0.05
estimate
—
0
57
75
850
0.84
0.60
2.6
2.7
49.39
115.32
ng/l
0.30
34
430
0
21
0.00
0.60
0.0
1.4
—
0.84
—
0
10
0
22
0.00
0.59
0.0
1.2
—
32.95
—
0
22
21
158
1.35
0.59
1.0
1.1
1.61
1.64
g/l
0.17
21
158
12
81
1.50
0.58
1.0
1.1
6.21
1.94
u/ml
—
5
43
15
108
1.41
0.54
1.4
1.3
—
—
—
0
0
57
655
0.84
0.54
2.7
3.1
1.01
1.02
kg/l
1.15
44
409
12
168
0.70
0.52
1.0
1.1
—
93.33
—
0
6
50
429
1.20
0.51
2.0
2.5
137.16
89.26
ug/g
0.36
45
351
40
472
0.82
0.50
1.4
1.6
456.40
35613638.19
pmol/l
0.80
35
424
41
346
1.21
0.50
1.7
1.7
3.54
3.43
mmol/l
0.25
29
250
15
110
1.38
0.49
1.9
2.1
6.67
5.20
iu/l
—
5
47
252
2593
0.85
0.48
4.2
4.3
5.64
5.69
mmol/l
0.31
242
2454
125
1158
1.13
0.48
2.7
2.9
6.14
6.18
ph
0.16
70
685
8
116
0.68
0.46
1.3
1.1
—
—
—
0
0
75
673
1.15
0.46
1.4
1.4
2.05
2.13
g/l
0.11
37
436
84
762
1.14
0.44
1.2
1.3
0.72
1.74
u/ml
—
10
227
69
765
0.87
0.42
3.1
3.0
6.90
7.64
mmol/l
0.65
62
665
246
2527
0.87
0.40
5.0
5.0
38.04
37.63
mmol/mol
0.41
240
2419
13
97
1.36
0.40
1.8
2.2
—
—
—
0
0
8
61
1.32
0.40
1.0
2.0
1.78
1.25
g/l
—
8
55
10
135
0.73
0.37
5.9
5.1
3.24
1.93
ug/l
—
10
122
6
41
1.47
0.36
1.0
1.4
0.57
0.52
nmol/l
—
6
41
6
41
1.47
0.36
1.2
1.3
—
—
—
0
0
12
91
1.33
0.34
1.5
1.2
—
—
—
0
0
33
285
1.18
0.34
1.2
1.2
159.03
156.10
u/ml
0.02
16
129
273
2679
1.16
0.32
5.6
5.6
1.77
1.77
mu/l
0.01
263
2563
110
1034
1.10
0.31
2.1
1.9
106.82
100.55
pmol/l
1.15
61
546
8
63
1.28
0.28
1.0
1.3
—
—
—
0
0
12
150
0.79
0.27
1.3
1.4
—
—
—
0
0
8
66
1.22
0.27
1.0
1.2
3.58
3.64
mmol/l
—
8
61
23
197
1.18
0.26
1.4
1.5
94.27
58.12
ug/l
1.15
16
162
19
162
1.18
0.23
1.2
1.3
156.64
268.83
miu/ml
1.21
11
81
5
38
1.32
0.23
4.0
3.0
—
—
—
0
0
7
92
0.76
0.23
27.7
5.9
—
—
—
0
0
15
178
0.83
0.22
2.5
2.7
—
—
—
0
0
5
41
1.22
0.22
1.0
1.5
—
72.48
—
0
5
0
11
0.00
0.21
0.0
2.4
—
2230.00
—
0
11
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
0.00
—
0
13
0
13
0.00
0.21
0.0
2.2
—
274.23
—
0
13
0
13
0.00
0.21
0.0
1.1
—
1925.46
—
0
13
0
13
0.00
0.21
0.0
2.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
53
492
1.09
0.20
1.5
1.5
—
—
—
0
0
139
1436
0.94
0.18
3.0
3.2
0.50
5.05
estimate
—
10
279
239
2351
1.07
0.17
4.6
4.8
13.95
14.37
pmol/l
2.07
232
2236
5
66
0.75
0.17
3.2
2.7
—
—
—
0
0
5
69
0.72
0.17
2.0
1.4
—
—
—
0
0
12
141
0.85
0.16
1.7
1.4
—
—
—
0
0
19
214
0.88
0.16
1.1
1.2
—
—
—
0
0
13
151
0.85
0.16
1.6
1.4
—
—
—
0
0
15
171
0.87
0.15
1.3
1.5
294.00
310.06
mu/l
0.05
15
151
14
160
0.87
0.14
1.0
1.2
—
—
—
0
0
12
139
0.86
0.14
4.8
2.3
65.52
69.06
g/l
0.56
12
132
13
149
0.87
0.14
1.6
1.4
—
—
—
0
0
13
149
0.87
0.14
1.6
1.4
—
—
—
0
0
43
455
0.94
0.12
1.3
1.4
392.00
608.08
titre
—
10
104
66
687
0.95
0.11
1.5
1.4
22.37
28.48
iu/ml
0.37
15
206
139
1421
0.96
0.11
3.0
3.2
0.00
0.00
estimate
—
9
276
16
177
0.90
0.10
1.0
1.1
—
—
—
0
0
12
135
0.88
0.10
1.6
2.3
81.70
73.07
e9/l
—
6
97
65
673
0.96
0.09
3.4
3.7
2.99
7.61
mg/mmol
1.62
33
393
117
1194
0.97
0.08
1.9
1.9
1.44
1.34
mmol/l
0.69
107
1052
11
98
1.13
0.07
1.5
2.3
0.82
0.57
%
0.75
11
98
6
71
0.84
0.07
1.0
1.1
—
—
—
0
0
8
74
1.08
0.07
3.5
3.2
—
—
—
0
0
8
92
0.87
0.07
1.0
1.2
—
—
—
0
0
43
415
1.04
0.06
2.2
2.0
—
—
—
0
0
63
646
0.97
0.05
1.6
1.5
22.68
21.29
nmol/l
0.38
58
561
41
396
1.04
0.05
1.3
1.3
—
—
—
0
0
11
100
1.10
0.05
1.5
2.3
1.50
1.06
%
0.72
11
100
12
110
1.09
0.05
1.9
1.5
—
—
—
0
0
11
120
0.91
0.05
1.5
1.3
—
—
—
0
0
65
665
0.97
0.05
3.0
3.3
18.26
45.17
mg/l
1.45
40
408
64
652
0.98
0.03
2.0
2.0
2.78
2.63
mg/l
0.09
54
577
36
368
0.98
0.01
1.4
1.2
—
—
—
0
0
10
106
0.94
0.01
1.8
1.5
—
—
—
0
0
20
198
1.01
0.00
1.3
1.2
—
55.02
—
0
14
21
213
0.98
0.00
2.4
2.1
5.91
6.16
ph
0.64
16
128
144
1443
1.00
0.00
3.0
3.3
0.00
0.01
estimate
—
7
266
18
176
1.02
0.00
1.1
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
4.4
—
7.61
—
0
8
0
7
0.00
-0.00
0.0
2.7
—
13.86
—
0
7
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
7
76
0.92
-0.00
1.1
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.4
—
30.75
—
0
8
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
63
630
1.00
-0.00
1.3
1.3
5.20
10.49
u/ml
0.92
23
262
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
—
—
0
0
5
57
0.88
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
0.02
—
0
7
6
65
0.92
-0.00
3.7
2.6
1.12
1.22
mg/l
—
6
59
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
29
290
1.00
-0.00
2.1
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
54.00
—
0
5
0
9
0.00
-0.00
0.0
3.8
—
8.79
—
0
9

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: Z21_PROPHYLACT_SURGE – Prophylactic surgery

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).