No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
672 |
4. Check minimum number of eventsNone |
672 |
5. Include endpointsNone |
672 |
6. Filter based on genotype QC (FinnGen only) |
578 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF10
Mandibular prognathia
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10540 | 4767 | 5746 |
| Only index persons | 9023 | 4093 | 4930 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.14 | 0.16 |
| Only index persons | 0.17 | 0.15 | 0.19 |
| Median age at first event (years) | |||
| Whole population | 13.23 | 13.24 | 13.15 |
| Only index persons | 14.49 | 14.49 | 14.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 578 | 336 | 242 |
| Unadjusted period prevalence (%) | 0.12 | 0.12 | 0.11 |
| Median age at first event (years) | 32.40 | 30.74 | 34.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 633
- Matched controls
- 6330
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K07.11
ICD-10 Finland
Retrognathism (mandibular)(maxillary)
+∞
307.7
633
*
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
30.4
307.7
289
170
K07.14
ICD-10 Finland
Retrognaty, maxillary
278.5
307.7
219
12
SBB10
NOMESCO Finland
Dental impressions
13.4
250.5
387
665
EB1MA
NOMESCO Finland
Cephalometry with X-ray
15.5
233.9
251
258
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
15.3
216.6
227
223
EDC10
NOMESCO Finland
Sagittal osteotomy of ramus of mandible
114.2
204.9
105
11
SJD00
NOMESCO Finland
Removal and/or reactivation of orthodontic arch wire
12.8
198.6
239
286
SJD20
NOMESCO Finland
Placement of modified orthodontic arch wire
13.8
180.2
195
198
SJD10
NOMESCO Finland
Placement of orthodontic arch wire
11.4
175.0
227
297
SJC50
NOMESCO Finland
Removal of fixed orthodontic appliance with at least 7 brackets
11.8
169.0
207
250
EEC05
NOMESCO Finland
Le Fort I osteotomy
671.3
162.8
154
*
K07.10
ICD-10 Finland
Asymmetry of jaw
96.7
160.7
84
10
SJC10
NOMESCO Finland
Orthodontic band in one tooth
10.8
149.3
192
245
SJD30
NOMESCO Finland
Demanding placement of orthodontic arch wire
14.3
141.2
141
124
K07.24
ICD-10 Finland
Open bite
20.8
139.3
111
64
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
13.1
133.8
142
137
SJD40
NOMESCO Finland
Placement of prefabricated palatal or lingual arch
8.8
127.2
195
305
SJX10
NOMESCO Finland
Orthodontic treatment/control appointment, short
7.8
125.2
222
408
SAA04
NOMESCO Finland
Special examination of mouth
8.3
124.9
203
339
SJB00
NOMESCO Finland
Fitting of removable appliance incl. patient instructions
8.2
115.0
184
300
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
8.5
95.6
141
207
K07.13
ICD-10 Finland
Retrognaty, mandibular
13.5
90.4
90
77
K07.21
ICD-10 Finland
Anomalies of dental arch relationship
35.3
86.2
55
17
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
6.7
75.2
137
250
SXC05
NOMESCO Finland
Other oral or dental procedure
4.9
71.5
204
556
SAA03
NOMESCO Finland
Extended examination of mouth
4.4
62.7
468
2482
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
4.7
59.8
175
480
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
5.5
58.5
131
287
SJX20
NOMESCO Finland
Orthodontic treatment/control appointment
5.9
55.7
112
222
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
6.9
54.9
92
152
K07.1
ICD-10 Finland
Anomalies of jaw-cranial base relationship
150.3
52.7
55
*
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
5.1
52.1
127
298
SJB60
NOMESCO Finland
Adjustment and grinding of removable appliance
5.7
51.5
106
214
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
3.5
49.9
418
2254
SJC00
NOMESCO Finland
Bondable bracket or other fixed attachement
86.0
49.8
55
7
SJC40
NOMESCO Finland
Removal of fixed orthodontic appliance with at most 6 brackets
4.9
49.3
126
307
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
5.1
48.8
117
270
EBB10
NOMESCO Finland
Insertion of dental implant
17.7
48.3
40
24
WZC00
NOMESCO Finland
Treatment plan or consultation
3.3
48.2
374
1912
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
4.9
48.2
121
290
K07.60
ICD-10 Finland
Snapping jaw
5.5
47.2
100
207
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
6.8
43.9
73
119
SJA04
NOMESCO Finland
Very demanding workplan for orthodontic treatment
118.0
41.3
44
*
K07.01
ICD-10 Finland
Hyperplasia, hypoplasia mandibular
115.1
40.3
43
*
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
3.8
36.0
126
384
SAC03
NOMESCO Finland
Separate planning of oral and dental treatment, very demanding
11.8
35.6
37
33
SJA03
NOMESCO Finland
Demanding workplan for orthodontic treatment
54.6
34.9
41
8
K07.18
ICD-10 Finland
Another anomaly in the relationship between jaw and skull base
98.1
34.1
37
*
EFB40
NOMESCO Finland
Removal of internal or external fixation device from facial bones
39.7
32.9
41
11
SJA01
NOMESCO Finland
Assesment of orthodontic treatment need
42.6
32.5
40
10
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
11.6
28.6
30
27
K07.12
ICD-10 Finland
Prognathism (mandibular)(maxillary)
67.3
28.2
32
5
K07.03
ICD-10 Finland
Micrognatia (hypoplasia) of the upper jaw
81.5
28.0
31
*
K07.30
ICD-10 Finland
Spacing, abnormal of tooth or teeth
3.5
26.2
102
330
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
6.7
25.9
42
66
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
8.5
25.8
34
42
K00.00
ICD-10 Finland
Hypodontia
5.6
23.1
45
85
SAC02
NOMESCO Finland
Separate planning of oral and dental treatment, demanding
4.3
22.9
62
155
SJD50
NOMESCO Finland
Placement of prefabricated palatal or lingual arch, dentist-made
7.1
22.3
34
50
K07.19
ICD-10 Finland
Anomalies in the relationship between jaw and skull base UNS
83.1
21.8
24
*
SHA04
NOMESCO Finland
Stomatognathic treatment, very demanding
8.6
21.5
28
34
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
7.2
20.5
31
45
SJX00
NOMESCO Finland
Reparation of orthodontic appliance by dentist
7.0
20.1
31
46
K07.69
ICD-10 Finland
Dislocation of the jaw joint UNS
6.9
19.7
31
47
K07.4
ICD-10 Finland
Malocclusion, unspecified
5.2
18.0
38
77
EB1WA, ,
NOMESCO Finland
18.0
17.1
26
15
EBB15
NOMESCO Finland
Insertion of dental implant abutment
20.7
16.5
24
12
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.7
15.9
52
149
SXC03
NOMESCO Finland
Other oral or dental procedure
16.2
15.8
25
16
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
5.8
15.7
29
52
SAA02
NOMESCO Finland
Basic examination of mouth
2.4
15.1
535
4376
ZXE20
NOMESCO Finland
More than three and less than five hours
2.6
15.0
99
426
G50.1
ICD-10 Finland
Atypical facial pain
7.0
14.9
23
34
SJA02
NOMESCO Finland
Workplan for orthodontic treatment
32.6
14.9
19
6
SJB10
NOMESCO Finland
Fitting of removable appliance incl. patient instructions, demanding
3.7
14.2
46
131
Z3229
NOMESCO Finland
Other healthcare associate professional
2.8
14.0
76
295
WZA90
NOMESCO Finland
Other medical or dental certificate
2.0
13.9
207
1240
EB1S1
NOMESCO Finland
Photography of teeth
6.2
13.5
23
38
OIKK, ,
NOMESCO Finland
2.8
13.4
74
290
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
21.7
13.4
19
9
SXB00
NOMESCO Finland
Removal of sutures from oral mucosa
3.1
13.4
60
210
SPC20
NOMESCO Finland
Implant borne crown
19.5
13.0
19
10
SPB10
NOMESCO Finland
Manufacture of a temporary crown to tooth at the dental office
15.8
12.7
20
13
SAA01
NOMESCO Finland
Simple examination of mouth
2.2
12.6
522
4325
SAC01
NOMESCO Finland
Separate planning of oral and dental treatment, standard
3.0
12.3
56
197
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
11.4
177
1065
SPA02
NOMESCO Finland
Preparation for dental prosthetics
4.1
11.3
31
78
SPC10
NOMESCO Finland
Standard dental crown
9.9
11.3
22
23
QA1S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head
11.4
11.1
20
18
SPA20
NOMESCO Finland
Selection and insertion of implant abutment
28.6
10.8
14
5
EBA00
NOMESCO Finland
Extraction of tooth
1.8
10.8
291
2065
SJB30
NOMESCO Finland
Extraoral traction arrangements and operation instruction, removable appliance
4.0
10.7
30
77
SPF00
NOMESCO Finland
Reparation of dental prosthesis without impressions
8.2
10.7
23
29
SJF01
NOMESCO Finland
Assessment of need for orthodontic treatment
2.6
10.5
64
264
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
13.4
10.2
17
13
SDA03
NOMESCO Finland
Periodontal treatment
1.7
9.5
278
1995
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
2.2
9.4
89
446
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
3.5
9.2
31
91
Z97.2
ICD-10 Finland
Presence of dental prosthetic device (complete)(partial)
4.9
9.1
20
42
Z01.2
ICD-10 Finland
Dental examination
1.7
9.1
362
2809
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.7
8.8
211
1429
WX110
NOMESCO Finland
Infiltration anesthesia
1.8
8.7
492
4169
SJE90
NOMESCO Finland
Orthodontic finishing
8.4
8.6
18
22
K01.0
ICD-10 Finland
Embedded teeth
3.3
8.5
31
96
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.5
8.4
29
86
EDC30
NOMESCO Finland
Genioplasty
+∞
8.3
8
*
SDA02
NOMESCO Finland
Periodontal treatment, brief
1.6
8.3
261
1890
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.0
8.2
101
557
SPAT1301
SPAT
No procedures
1.7
8.2
198
1340
EEC02
NOMESCO Finland
Rapid expansion of maxilla
33.8
8.1
10
*
SPC40
NOMESCO Finland
Preparation of first or second intermediate attachment tooth for bridge
22.3
8.0
11
5
K07.26
ICD-10 Finland
Anomalies of dental arch relationship
13.2
7.9
13
10
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.8
7.9
40
150
SFA10
NOMESCO Finland
One-surface restoration
1.6
7.8
388
3129
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.7
7.8
154
984
SDA04
NOMESCO Finland
Demanding periodontal treatment
1.7
7.7
196
1341
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.6
7.6
342
2685
ZXX07
NOMESCO Finland
Extent of procedure, 7 units
81.0
7.4
8
*
K00.09
ICD-10 Finland
Lack of teeth due to lack of dental development UNS
7.8
7.4
16
21
F45.8
ICD-10 Finland
Other somatoform disorders
2.2
7.4
60
282
EBA10
NOMESCO Finland
Operative extraction of tooth
1.8
7.3
136
851
K07.29
ICD-10 Finland
Anomaly in the relationship between the tooth arches UNS
+∞
7.3
7
*
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.7
7.3
147
942
T84.62
ICD-10 Finland
Osteitis associated with dental implants
20.3
7.1
10
5
SPB20
NOMESCO Finland
Temporary bridge
20.3
7.1
10
5
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
3.8
7.1
21
56
SPA51
NOMESCO Finland
Determination of bite and dental arch location, demanding
8.9
7.1
14
16
SPA47
NOMESCO Finland
Precision impression for denture
3.9
6.9
20
53
SPA48
NOMESCO Finland
Precision impression for denture, demanding
16.9
6.8
10
6
K07.04
ICD-10 Finland
Macrognathism (mandibular)(maxillary)
16.9
6.8
10
6
Z96.5
ICD-10 Finland
Presence of tooth-root and mandibular implants
16.9
6.8
10
6
SGB10
NOMESCO Finland
Root filling of tooth with one root canal
2.0
6.7
72
377
ZXA10
NOMESCO Finland
Bilateral
1.8
6.6
105
626
SPD01
NOMESCO Finland
Mucosa-supported complete denture
8.8
6.6
13
15
SDA01
NOMESCO Finland
Periodontal treatment, very brief
1.6
6.5
238
1765
J01CE02
ATC
phenoxymethylpenicillin; oral
1.6
6.5
423
3559
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
6.3
91
526
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
6.3
119
748
SPA10
NOMESCO Finland
Setting attachments on tooth or implanted bracket or imblant based structures
+∞
6.3
6
*
SPA52
NOMESCO Finland
Determination of bite and dental arch location, very demanding
27.0
6.2
8
*
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.5
6.2
295
2308
K08.2
ICD-10 Finland
Atrophy of edentulous alveolar ridge
7.8
6.1
13
17
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
59
256
2.44
8.68
3.1
3.3
122.96
151.26
ng/l
0.26
54
235
296
2369
1.47
5.30
8.2
8.5
1.22
1.22
mmol/l
0.94
266
2115
352
2926
1.46
5.10
5.0
5.6
6.53
6.42
mmol/l
0.45
329
2708
341
2850
1.43
4.61
3.9
3.6
0.00
0.01
estimate
0.80
57
569
335
2829
1.39
4.06
3.9
3.6
27.88
2.53
estimate
0.43
60
595
176
1330
1.45
4.03
3.9
3.2
1.02
1.02
kg/l
0.19
112
837
121
857
1.51
3.82
1.8
1.6
421.06
40079807.14
pmol/l
1.24
107
756
528
4858
1.52
3.79
17.5
16.5
13.30
13.30
%
0.02
522
4806
327
2803
1.34
3.36
3.9
3.5
0.00
0.00
estimate
-0.00
58
600
18
71
2.58
3.32
1.9
1.7
13.16
13.13
%
0.05
18
71
242
2001
1.34
3.10
5.3
6.0
37.04
37.19
g/l
0.17
229
1906
470
4289
1.37
3.02
5.0
4.2
14.45
14.53
pmol/l
0.35
443
3953
427
3846
1.34
2.95
4.5
4.3
9.17
9.18
mm/h
0.00
413
3617
255
2144
1.32
2.85
7.4
8.3
1.22
1.22
mmol/l
0.36
236
2014
84
591
1.49
2.74
2.3
2.3
419.65
369.07
nmol/l
0.57
78
559
531
4971
1.42
2.72
5.9
5.1
1.82
1.85
mu/l
0.23
504
4680
158
1248
1.35
2.69
1.6
1.5
18.51
20.16
nmol/l
0.89
140
1081
18
80
2.29
2.63
3.4
3.0
7.76
7.37
mmol/l
0.16
18
74
21
100
2.14
2.61
3.2
2.8
1.41
1.31
mmol/l
0.34
21
94
186
1512
1.33
2.60
2.5
2.7
56.41
61.67
u/l
0.61
175
1424
554
5241
1.46
2.54
16.3
14.4
3.96
3.93
mmol/l
1.11
546
5109
283
2444
1.29
2.50
2.8
2.8
—
—
estimate
—
0
0
553
5237
1.44
2.44
16.3
14.3
139.60
139.66
mmol/l
0.26
547
5126
65
445
1.51
2.43
7.3
10.8
0.72
0.50
mmol/l
0.21
52
376
107
809
1.39
2.38
2.8
2.8
14.03
14.39
umol/l
0.21
99
759
99
743
1.39
2.30
2.8
2.8
2.49
2.41
g/l
0.78
91
693
169
1378
1.31
2.28
2.7
2.5
2.43
2.63
mg/l
0.65
153
1216
11
40
2.78
2.28
2.1
1.9
—
1224630.00
iu/ml
—
0
5
42
265
1.63
2.24
2.0
1.6
—
—
—
0
0
570
5445
1.47
2.23
14.4
12.8
20.56
21.95
mg/l
0.54
457
4248
109
840
1.36
2.16
3.8
3.5
57.06
676.15
ng/l
3.81
76
538
485
4530
1.30
2.10
6.4
5.2
38.03
37.83
mmol/mol
0.20
469
4316
189
1582
1.28
2.07
2.8
3.1
2.37
2.36
mmol/l
0.33
175
1457
6
15
4.03
2.04
2.0
2.3
123.25
89.24
ng/l
—
6
15
17
83
2.08
2.03
1.3
1.2
—
—
—
0
0
82
611
1.39
2.00
1.5
1.6
1182.88
1156.06
nmol/l
0.11
65
479
373
3387
1.25
1.99
4.9
4.2
279.63
823.02
e6/l
—
8
46
411
3775
1.25
1.97
7.1
7.6
79.53
83.33
u/l
0.55
398
3592
7
21
3.36
1.97
1.0
3.1
213.57
195.19
u/l
—
7
21
475
4445
1.27
1.90
3.8
3.6
—
—
—
0
0
192
1633
1.25
1.82
3.4
2.9
0.00
0.01
estimate
0.69
46
502
208
1787
1.24
1.80
1.6
1.6
0.89
2.48
u/ml
2.50
50
449
199
1713
1.24
1.67
4.7
3.8
8.47
8.47
mmol/l
0.00
181
1525
243
2136
1.22
1.67
3.8
3.3
0.04
0.02
estimate
0.28
45
516
97
765
1.32
1.66
8.2
8.6
1.07
1.12
mmol/l
0.93
86
724
19
105
1.83
1.64
1.6
1.6
53.61
23.89
ng/l
0.42
19
105
86
671
1.33
1.59
3.0
2.9
22.91
24.26
%
0.44
78
636
14
258
0.53
1.56
3.3
2.1
4.40
5.36
iu/ml
—
5
55
154
1300
1.24
1.54
5.1
4.4
6.98
9.82
mg/mmol
0.53
99
877
240
2122
1.21
1.54
2.0
1.9
1.37
1.36
mmol/l
0.04
207
1881
51
370
1.41
1.49
2.2
3.9
4.52
4.75
pmol/l
0.74
46
338
280
2521
1.20
1.46
5.5
6.7
12.70
11.32
umol/l
0.77
269
2394
7
28
2.52
1.45
1.3
1.4
—
—
—
0
0
9
39
2.33
1.43
7.6
5.1
1.12
1.69
ug/l
—
9
39
51
373
1.40
1.43
2.2
1.8
15.63
15.85
iu/l
0.02
45
293
515
4922
1.25
1.38
4.8
4.4
4.53
4.62
mmol/l
1.36
494
4695
216
1909
1.20
1.36
2.1
1.9
100.26
97.58
pmol/l
0.33
122
992
0
39
0.00
1.34
0.0
1.3
—
—
—
0
0
9
42
2.16
1.34
2.3
2.6
105.67
105.71
mmol/l
—
9
42
9
42
2.16
1.34
2.3
2.6
1.18
1.19
mmol/l
—
9
42
45
328
1.40
1.30
2.2
1.9
7.19
7.86
u/l
0.27
39
251
9
44
2.06
1.27
1.4
1.6
0.48
0.51
e9/l
—
9
44
516
4947
1.23
1.25
5.3
4.8
2.67
2.75
mmol/l
1.16
496
4702
20
123
1.65
1.25
1.9
1.5
—
—
—
0
0
511
4898
1.22
1.22
4.7
4.3
1.41
1.44
mmol/l
0.92
489
4645
212
1887
1.19
1.22
3.5
3.7
31.56
30.04
u/l
0.44
205
1796
77
619
1.28
1.18
2.6
4.7
13.69
7.90
umol/l
0.39
70
546
0
34
0.00
1.16
0.0
3.4
—
46.81
—
0
34
5
20
2.51
1.15
1.0
1.1
—
—
—
0
0
492
4712
1.20
1.11
5.0
4.1
5.80
5.73
mmol/l
0.60
472
4385
9
162
0.55
1.10
1.6
1.3
—
—
—
0
0
17
106
1.62
1.03
4.3
3.1
42.89
17.57
mu/l
0.51
17
101
5
22
2.28
1.03
2.8
2.7
0.63
0.60
mmol/l
—
5
22
16
99
1.63
1.00
1.4
1.4
—
—
—
0
0
16
99
1.63
1.00
1.4
1.4
—
—
—
0
0
18
115
1.58
1.00
6.8
1.7
—
—
—
0
0
7
35
2.01
1.00
3.3
2.7
558.00
666.80
u/ml
—
7
35
7
132
0.53
1.00
1.1
1.3
—
—
—
0
0
132
1148
1.19
0.99
1.7
2.3
1.17
1.20
mg/l
0.02
104
861
48
373
1.31
0.97
1.8
1.5
—
—
—
0
0
10
54
1.87
0.97
1.8
1.2
—
—
—
0
0
314
2924
1.15
0.96
3.8
3.3
156.19
86.53
ug/l
0.39
298
2787
65
527
1.26
0.96
3.0
2.2
11.29
12.70
nmol/l
0.72
56
494
261
2400
1.15
0.96
3.7
2.9
73.85
71.90
nmol/l
0.55
250
2234
11
62
1.79
0.94
1.4
1.2
—
—
—
0
0
10
55
1.83
0.92
1.8
1.2
—
—
—
0
0
10
55
1.83
0.92
1.4
1.6
—
—
—
0
0
202
1828
1.15
0.92
2.2
1.9
—
—
—
0
0
342
3216
1.14
0.88
8.8
10.2
3.74
3.86
e9/l
0.52
298
2782
8
45
1.79
0.84
1.1
1.2
213.28
189.72
pmol/l
—
8
45
396
3771
1.13
0.81
3.5
3.6
40.20
39.77
u/l
0.04
387
3610
175
1583
1.15
0.80
3.3
3.2
47.18
76.42
ng/l
0.27
98
936
28
372
0.74
0.80
1.4
1.4
—
—
—
0
0
14
90
1.57
0.78
8.4
4.0
4.89
4.97
kpa
0.27
14
90
12
74
1.63
0.78
1.8
1.9
5.78
4.96
mmol/24h
0.26
12
66
66
551
1.22
0.78
2.2
1.9
—
—
—
0
0
61
505
1.23
0.78
2.3
2.5
32.20
130.52
u/l
0.52
51
427
86
738
1.19
0.77
2.1
2.0
—
—
—
0
0
64
536
1.22
0.74
2.1
1.9
—
—
—
0
0
610
6022
1.36
0.71
22.2
19.7
253.97
257.96
e9/l
0.88
600
5906
71
604
1.20
0.70
4.6
7.6
1.42
1.49
mmol/l
0.07
63
504
571
5598
1.20
0.69
10.9
10.6
27.48
26.84
u/l
0.29
561
5462
5
27
1.86
0.68
1.6
1.6
4.32
5.02
nmol/l
—
5
27
5
29
1.73
0.64
5.0
2.9
67.40
119.05
ug/l
—
5
29
610
6028
1.33
0.63
22.1
19.6
4.61
4.59
e12/l
0.63
598
5901
5
30
1.67
0.61
1.0
1.6
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
40.36
—
0
20
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.3
—
—
—
0
0
14
97
1.45
0.59
3.1
3.6
16.20
30.13
mg/l
—
7
68
28
353
0.78
0.58
1.9
2.9
81.55
73.51
ml/min/173m2
0.29
11
154
0
23
0.00
0.58
0.0
1.3
—
67.43
—
0
23
28
220
1.29
0.58
1.1
1.2
3.33
1.87
u/ml
0.25
18
144
59
505
1.19
0.57
1.4
1.3
93.10
135.76
u/ml
0.73
24
201
59
505
1.19
0.57
11.2
12.3
24.58
24.78
mmol/l
0.26
59
505
6
36
1.67
0.57
1.2
1.2
—
—
—
0
0
105
941
1.14
0.56
1.3
1.3
8.20
9.98
u/ml
0.11
44
373
17
228
0.74
0.55
3.1
1.6
1.09
1.18
g/l
0.65
17
217
15
108
1.40
0.53
8.0
5.0
8.77
8.12
pmol/l
0.11
15
108
10
66
1.52
0.52
2.2
3.4
—
—
—
0
0
17
225
0.75
0.51
3.1
1.6
0.20
0.23
g/l
0.70
17
216
13
92
1.42
0.51
1.8
1.2
—
—
—
0
0
114
1036
1.12
0.50
4.2
3.6
930.72
801.36
ng/l
0.19
91
867
84
749
1.14
0.50
2.4
2.1
—
—
—
0
0
7
106
0.66
0.49
1.0
2.1
0.00
0.00
g/l
—
7
101
21
267
0.78
0.49
1.5
1.4
—
—
—
0
0
137
1261
1.11
0.48
2.3
2.4
—
—
—
0
0
7
47
1.49
0.47
1.1
1.1
—
—
—
0
0
141
1302
1.11
0.47
2.4
2.2
153.16
258.96
u/l
1.27
132
1247
96
869
1.12
0.46
2.5
2.2
—
—
—
0
0
27
219
1.24
0.46
1.0
1.2
3.07
0.86
u/ml
0.37
18
133
37
311
1.20
0.45
1.8
1.8
—
—
—
0
0
5
85
0.58
0.45
1.2
1.6
—
—
—
0
0
11
152
0.72
0.44
2.5
1.9
—
—
—
0
0
16
121
1.33
0.44
4.3
2.8
—
—
—
0
0
30
248
1.22
0.43
1.1
1.2
1.80
2.80
u/ml
0.26
19
160
57
647
0.87
0.43
2.9
2.9
0.70
0.74
ug/l
0.08
33
370
28
230
1.23
0.43
1.4
1.7
2.78
7.59
u/ml
—
5
61
39
332
1.19
0.43
1.6
1.7
—
—
—
0
0
52
454
1.16
0.42
5.6
6.3
1.54
1.48
mmol/l
0.05
35
322
8
58
1.38
0.41
1.0
1.1
—
—
—
0
0
161
1507
1.09
0.41
3.9
3.5
0.00
0.01
estimate
0.88
55
572
5
33
1.52
0.41
1.0
1.6
78.20
82.33
%
—
5
33
0
16
0.00
0.41
0.0
1.0
—
8.17
—
0
6
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
5
34
1.47
0.40
1.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
25
205
1.23
0.40
5.7
4.3
36.33
50.02
%
1.90
25
198
25
205
1.23
0.40
5.0
2.9
1.02
1.02
ratio
0.18
18
191
7
102
0.68
0.40
2.7
1.8
—
—
—
0
0
474
4637
1.09
0.39
3.9
3.7
1.28
1.24
mmol/l
0.44
448
4377
7
104
0.67
0.39
1.0
2.0
0.00
0.00
g/l
—
7
94
35
298
1.18
0.39
1.6
2.1
7.38
9.04
ug/l
0.20
29
267
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
17
133
1.29
0.39
6.2
7.8
—
2487.91
u/ml
—
0
11
14
181
0.77
0.38
2.0
1.3
—
18.14
—
0
9
17
214
0.79
0.38
1.4
1.5
—
0.03
—
0
38
27
225
1.21
0.37
1.1
1.2
14.41
7.26
u/ml
0.84
19
158
9
123
0.73
0.35
1.2
2.1
2.59
2.95
g/l
—
9
117
6
89
0.67
0.33
3.3
1.7
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
15
119
1.27
0.32
2.7
5.8
0.27
0.35
iu/ml
—
7
63
7
52
1.35
0.31
1.0
1.0
—
—
—
0
0
167
1586
1.07
0.31
1.6
1.5
1.84
2.09
g/l
1.39
107
959
18
147
1.23
0.31
1.2
1.1
9.52
10.11
u/ml
0.04
12
79
123
1156
1.08
0.30
2.8
3.1
346.28
332.45
umol/l
0.84
114
1053
116
1089
1.08
0.29
5.0
4.8
1.58
1.73
ug/l
0.40
106
985
10
129
0.77
0.28
2.4
1.6
—
—
—
0
0
13
103
1.27
0.28
1.9
1.5
—
—
—
0
0
20
237
0.84
0.28
2.0
2.5
15.99
42.29
u/ml
1.66
20
227
27
311
0.86
0.27
1.6
1.6
0.11
0.26
mg/l
1.86
11
129
9
116
0.77
0.27
1.2
2.2
0.14
0.47
g/l
—
9
108
96
897
1.08
0.27
4.4
3.2
0.65
1.05
e6/l
0.95
51
453
107
1006
1.08
0.26
1.3
1.3
15.35
27.21
iu/ml
1.87
37
281
21
178
1.19
0.26
1.4
1.7
—
—
—
0
0
13
159
0.81
0.25
2.0
2.1
—
—
—
0
0
13
105
1.24
0.25
1.6
1.6
—
—
—
0
0
6
83
0.72
0.24
1.2
1.4
—
—
—
0
0
98
923
1.07
0.24
1.7
1.5
—
—
—
0
0
17
143
1.19
0.23
1.5
1.4
297.20
326.29
ug/g
—
10
80
67
719
0.92
0.22
1.5
1.8
3.37
3.44
ratio
0.17
47
542
5
42
1.19
0.21
1.4
1.6
—
—
—
0
0
5
42
1.19
0.21
1.4
1.6
—
—
—
0
0
5
42
1.19
0.21
1.4
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
3.1
—
25.60
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
14
166
0.84
0.20
2.2
1.8
—
—
—
0
0
13
155
0.84
0.20
1.6
2.4
166.00
304.44
ug/l
1.08
13
146
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
17
146
1.17
0.19
2.4
2.9
32.67
3.19
index
—
6
90
17
146
1.17
0.19
1.4
2.6
3.18
11.81
e6/l
0.97
11
113
101
961
1.06
0.19
3.3
3.0
173.14
102.44
ug/g
1.06
83
770
7
58
1.21
0.18
1.4
1.4
—
—
—
0
0
141
1463
0.95
0.17
4.6
3.5
0.48
0.33
e6/l
0.32
105
1044
162
1674
0.96
0.17
4.5
3.6
47.57
85.75
e6/l
0.38
126
1250
10
82
1.22
0.17
1.7
1.4
—
231.43
—
0
7
5
69
0.72
0.17
2.8
1.2
—
—
—
0
0
6
78
0.77
0.15
2.8
1.8
—
—
—
0
0
25
226
1.11
0.15
1.5
1.6
175.73
212.57
u/ml
0.53
15
114
26
286
0.91
0.15
1.2
1.4
—
—
—
0
0
21
234
0.89
0.15
1.3
1.3
—
—
—
0
0
143
1384
1.04
0.15
2.5
2.4
—
—
—
0
0
8
96
0.83
0.14
1.1
1.1
—
—
—
0
0
29
315
0.92
0.13
2.0
3.0
65.52
67.10
g/l
0.52
29
300
23
253
0.91
0.13
1.3
1.7
2.72
3.21
mg/l
0.19
18
173
10
85
1.18
0.12
1.3
1.6
—
90.00
—
0
5
45
424
1.07
0.12
3.4
2.8
—
—
—
0
0
22
241
0.91
0.12
1.8
1.7
—
—
—
0
0
54
568
0.95
0.12
1.4
1.6
914.00
993.87
mu/l
0.33
48
496
20
182
1.10
0.11
1.9
1.7
—
—
—
0
0
18
163
1.11
0.11
1.4
2.5
436.11
460.38
mg/l
0.11
18
156
116
1127
1.04
0.10
3.0
2.9
5.85
6.86
e6/l
0.35
110
1018
25
231
1.09
0.10
2.6
4.9
3.06
3.24
g/l
0.37
25
223
27
290
0.93
0.10
1.2
1.5
1.29
1.20
ratio
0.20
14
197
27
290
0.93
0.10
1.2
1.5
1.00
0.94
ratio
0.25
13
197
27
290
0.93
0.10
1.2
1.5
1.54
1.17
ratio
0.57
13
197
14
156
0.90
0.10
1.1
1.1
—
—
—
0
0
29
310
0.93
0.10
1.2
1.4
176.73
243.58
miu/ml
0.71
15
155
5
46
1.09
0.09
1.2
1.8
—
273.34
—
0
8
5
47
1.06
0.09
1.2
1.2
1.29
1.48
nmol/l
—
5
42
16
145
1.11
0.09
1.0
1.1
0.82
1.41
u/ml
—
7
62
5
48
1.04
0.09
1.2
1.2
78.20
112.06
pmol/l
—
5
48
25
268
0.93
0.09
1.6
1.7
—
—
—
0
0
14
155
0.90
0.09
1.1
1.1
—
—
—
0
0
133
1300
1.03
0.09
2.5
2.2
—
—
—
0
0
467
4702
0.97
0.09
13.2
11.5
93.03
92.49
ml/min/173m2
0.20
423
4168
6
57
1.05
0.08
2.3
1.8
—
—
—
0
0
44
460
0.95
0.08
1.0
1.1
—
—
—
0
0
5
65
0.77
0.08
1.0
1.1
—
—
—
0
0
53
551
0.96
0.08
1.4
1.6
3.12
3.39
mmol/l
0.78
33
380
6
74
0.81
0.07
2.3
1.6
—
—
—
0
0
8
78
1.03
0.07
2.0
1.7
—
—
—
0
0
14
153
0.91
0.07
2.9
3.4
487.57
1887.35
u/ml
0.68
14
132
24
255
0.94
0.07
1.0
1.1
1.47
1.52
g/l
0.49
24
255
32
336
0.95
0.07
2.8
4.2
2.73
28.92
ug/l
1.02
22
262
10
89
1.13
0.07
7.8
6.0
445.60
378.65
umol/l
—
10
82
8
92
0.87
0.07
1.6
1.4
—
—
—
0
0
24
226
1.06
0.06
1.5
1.4
—
—
—
0
0
12
132
0.91
0.06
1.2
2.0
4.24
4.23
g/l
0.01
12
126
12
132
0.91
0.06
1.2
2.0
6.87
7.31
g/l
0.69
12
126
12
132
0.91
0.06
1.1
2.0
3.37
3.70
g/l
0.46
12
126
11
99
1.11
0.06
1.7
1.4
—
—
—
0
0
13
142
0.91
0.06
1.0
1.1
—
—
—
0
0
16
149
1.08
0.05
1.2
2.4
3.77
3.61
mmol/l
0.34
16
143
31
323
0.96
0.05
1.4
1.5
83.28
63.38
ug/l
0.80
26
283
23
242
0.95
0.05
1.6
1.7
—
—
—
0
0
25
262
0.95
0.05
1.2
1.1
0.82
0.89
g/l
1.18
25
262
44
452
0.97
0.03
7.0
5.6
—
—
—
0
0
52
508
1.03
0.03
3.8
4.1
30.84
31.52
%
0.17
43
365
86
847
1.02
0.03
4.6
3.4
2.04
2.95
e6/l
0.82
43
409
10
108
0.92
0.03
1.3
1.2
—
—
—
0
0
12
112
1.07
0.03
1.5
2.2
—
—
—
0
0
14
132
1.06
0.02
1.9
1.6
—
—
—
0
0
45
460
0.98
0.02
2.4
2.4
13189.05
6001.41
u/l
0.27
15
178
15
158
0.95
0.02
2.1
1.7
—
—
—
0
0
18
172
1.05
0.02
1.3
1.1
5.47
6.31
u/ml
0.09
11
106
20
192
1.04
0.02
1.6
1.4
—
—
—
0
0
40
392
1.02
0.01
1.4
1.3
—
—
—
0
0
14
147
0.95
0.01
2.1
1.3
—
—
—
0
0
18
173
1.04
0.01
1.8
1.8
—
—
—
0
0
19
196
0.97
0.00
1.6
1.4
—
—
—
0
0
85
856
0.99
0.00
4.6
4.1
22.21
22.00
%
0.04
37
363
24
235
1.02
0.00
3.2
6.1
0.72
0.61
%
1.07
24
235
15
154
0.97
0.00
1.0
1.3
—
—
—
0
0
86
864
0.99
0.00
1.6
1.8
1.43
1.43
%
0.04
77
773
21
208
1.01
0.00
1.4
1.5
58.58
53.60
ug/l
0.22
21
208
18
179
1.01
0.00
2.1
1.7
186.67
132.76
au/ml
—
6
61
0
6
0.00
-0.00
0.0
1.0
—
285.83
—
0
6
5
51
0.98
-0.00
2.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.9
—
9.36
—
0
7
0
9
0.00
-0.00
0.0
1.1
—
1.56
—
0
9
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
53
0.94
-0.00
1.8
1.2
—
92.17
—
0
6
8
80
1.00
-0.00
2.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.3
—
49.92
—
0
6
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
8.60
—
0
5
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
-0.00
2.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
9.82
—
0
5
5
52
0.96
-0.00
2.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint K11_MN_PROGN and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_MN_PROGN | 0.831 [0.63, 1.1] | 0.196 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 4813 males with K11_MN_PROGN died.
Mortality risk
Mortality risk for people of age
years, who have K11_MN_PROGN.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.156% |
| 5 | No data | 0.989% |
| 10 | No data | 2.462% |
| 15 | No data | 4.535% |
| 20 | No data | 7.645% |
Relationships between endpoints
↥Index endpoint: K11_MN_PROGN – Mandibular prognathia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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